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PMC10001724	Increased Prolonged Sitting in Patients with Rheumatoid Arthritis during the COVID-19 Pandemic: A Within-Subjects, Accelerometer-Based Study	[ "Bruno Gualano", "Hamilton Roschel", "David W. Dunstan", "Neville Owen", "Eloisa Bonfá", "Ana Cristina de Medeiros Ribeiro", "Karina Bonfiglioli", "Kamila Meireles", "Sofia Mendes Sieczkowska", "Diego Rezende", "Ana Jessica Pinto" ]	Background: Social distancing measures designed to contain the COVID-19 pandemic can restrict physical activity, a particular concern for high-risk patient groups. We assessed rheumatoid arthritis patients’ physical activity and sedentary behavior level, pain, fatigue, and health-related quality of life prior to and du...	10.3390/ijerph20053944	[ "health-related quality of life", "fatigue", "pain", "inflammatory arthritis", "physical activity level", "sedentary behavior" ]	[{"citation_id": "B1-ijerph-20-03944", "related_text": ["A preliminary, multinational survey reporting step counts provided by smartphones showed that social distancing measures to contain the spread of SARS-CoV-2 have induced physical inactivity (i.e., not meeting the physical activity guidelines) [1]. The onset of th...	{"introduction": "A preliminary, multinational survey reporting step counts provided by smartphones showed that social distancing measures to contain the spread of SARS-CoV-2 have induced physical inactivity (i.e., not meeting the physical activity guidelines) [1]. The onset of the coronavirus disease 2019 (COVID-19) p...	[]	[]
PMC10003738	Impact of Age and Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection on Humoral Immune Responses After Three Doses of Coronavirus Disease 2019 mRNA Vaccine	[ "Mark A Brockman", "Zabrina L Brumme", "Marc G Romney", "Masahiro Niikura", "Janet Simons", "Daniel T Holmes", "Mari L DeMarco", "Christopher F Lowe", "Natalie Prystajecky", "Winnie Dong", "Julio S G Montaner", "Chanson J Brumme", "Siobhan Ennis", "Victor Leung", "Landon Young", "Laura...	Longer-term immune response data after 3 doses of coronavirus disease 2019 (COVID-19) mRNA vaccine remain limited, particularly among older adults and after Omicron breakthrough infection. We quantified wild-type- and Omicron-specific serum immunoglobulin (Ig)G levels, angiotensin-converting enzyme 2 displacement activ...	10.1093/ofid/ofad073	[ "postvaccination infection", "Omicron", "older adults", "mRNA vaccine", "COVID-19" ]	[{"citation_id": "ofad073-B1", "related_text": ["Third coronavirus disease 2019 (COVID-19) mRNA vaccine doses have been provided to clinically vulnerable individuals to complete their initial vaccine series [1–3] and more broadly as “booster doses” to offset the natural decline of systemic antibodies [4, 5] and to augm...	{"participants": "Our cohort, based in British Columbia (BC), Canada, has been described previously [20]. Here, we studied the 69 healthcare workers (HCWs) and 47 older adults (OAs) who remained COVID-19 naive until at least 1 month post-third COVID-19 vaccine dose (Table 1). Severe acute respiratory syndrome coronavir...	[{"id": "", "caption": "Wild-type (WT)-, Omicron BA.1-, and Omicron BA.5-specific live virus neutralization activity before and after attainment of hybrid immunity. (A) The WT-, Omicron BA.1-, and Omicron BA.5-specific neutralization activities in 28 healthcare workers ([HCW] blue circles) and 8 older adults ([OA] oran...	[{"caption": "Participant Characteristics", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col valign=\"top\" align=\"left\" span=\"1\" /><col valign=\"top\" align=\"center\" span=\"1\" /><col valign=\"top\" align=\"center\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\"...
PMC10004034	2-Year Change in Revised Hammersmith Scale Scores in a Large Cohort of Untreated Paediatric Type 2 and 3 SMA Participants	[ "Francesco Muntoni", "Eugenio Mercuri", "Richard S. Finkel", "Darryl C. De Vivo", "Basil T. Darras", "John W. Day", "Chiara Marini-Bettolo", "Matthew Civitello", "Sally Dunaway Young", "Tina Duong", "Amy Pasternak", "Zarazuela Zolkipli-Cunningham", "Allan M. Glanzman", "Jacqueline Montes",...	The Revised Hammersmith Scale (RHS) is a 36-item ordinal scale developed using clinical expertise and sound psychometrics to investigate motor function in participants with Spinal Muscular Atrophy (SMA). In this study, we investigate median change in the RHS score up to two years in paediatric SMA 2 and 3 participants ...	10.3390/jcm12051920	[ "spinal muscular atrophy", "natural history", "motor function" ]	[{"citation_id": "B1-jcm-12-01920", "related_text": ["Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene located on chromosome 5q leading to SMN protein deficiency [1,2,3,4]. It induces proximal muscle atrophy and weakness, leadi...	{"introduction": "Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene located on chromosome 5q leading to SMN protein deficiency [1,2,3,4]. It induces proximal muscle atrophy and weakness, leading to secondary complications includ...	[]	[]
PMC10004519	Association between intraoperative end-tidal carbon dioxide and postoperative organ dysfunction in major abdominal surgery: A cohort study	[ "Toshiyuki Mizota", "Yosuke Yamamoto", "Akiko Hirotsu", "Miho Hamada", "Tsukasa Kamitani", "Chikashi Takeda", "Li Dong" ]	Data on the effects of intraoperative end-tidal carbon dioxide (EtCO2) levels on postoperative organ dysfunction are limited. Thus, this study was designed to investigate the relationship between the intraoperative EtCO2 level and postoperative organ dysfunction in patients who underwent major abdominal surgery under g...	10.1371/journal.pone.0268362	[]	[{"citation_id": "pone.0268362.ref001", "related_text": ["Although high-risk surgeries account for only 12.5% of all surgical procedures, they account for more than 80% of surgery-related deaths [1]. Intraoperative organ hypoperfusion is a cause of poor outcomes and may lead to high postoperative mortality [2]. Therefo...	{"introduction": "Although high-risk surgeries account for only 12.5% of all surgical procedures, they account for more than 80% of surgery-related deaths [1]. Intraoperative organ hypoperfusion is a cause of poor outcomes and may lead to high postoperative mortality [2]. Therefore, markers that can be used to monitor ...	[{"id": "", "caption": "We included consecutive patients aged 18 years or older who underwent major abdominal surgery under general anesthesia at Kyoto University Hospital between 2012 and 2017. Then, we extracted the cases that met our eligibility criteria and analyzed them as complete cases.", "related_text": "Among ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10004542	Real-time emotion detection by quantitative facial motion analysis	[ "Sima Mofakham", "Pawel Polak", "Charles B. Mikell", "Miriam Rafailovich", "Michael Sepe", "Theresa Gammel", "Selma Mohammad", "Ryan Burgert", "Fan Yang", "Jordan R. Saadon" ]	Research into mood and emotion has often depended on slow and subjective self-report, highlighting a need for rapid, accurate, and objective assessment tools. To address this gap, we developed a method using digital image speckle correlation (DISC), which tracks subtle changes in facial expressions invisible to the nak...	10.1371/journal.pone.0282730	[]	[{"citation_id": "pone.0282730.ref001", "related_text": ["The ability to accurately assess the internal states of the human mind remains one of the grand challenges of modern neuroscience. In recent years, considerable research has been devoted to discovering new methods for identifying moods and emotions. There are a ...	{"introduction": "The ability to accurately assess the internal states of the human mind remains one of the grand challenges of modern neuroscience. In recent years, considerable research has been devoted to discovering new methods for identifying moods and emotions. There are a number of tools used to assess mood psyc...	[{"id": "", "caption": "(A)–(C): Different classifiers using the DISC method. (D): Amazon Rekognition. On the y–axis are the true emotion labels for the images; on the x–axis are the predicted emotion labels. The numbers in the plots indicate percentages of predicted labels for each true label. Correct predictions are ...	[]
PMC10004567	Prevalence of lung cancer in Colombia and a new diagnostic algorithm using health administrative databases: A real-world evidence study	[ "Giancarlo Buitrago", "Gabriel Torres", "Javier Amaya-Nieto" ]	Reliable, timely and detailed information on lung cancer prevalence, mortality and costs from middle-income countries is essential to policy design. Thus, we aimed to develop an electronic algorithm to identify lung cancer prevalent patients in Colombia by using administrative claims databases, as well as to estimate p...	10.1371/journal.pone.0269079	[]	[{"citation_id": "pone.0269079.ref001", "related_text": ["Lung cancer has progressed to be one of the most frequent and deadly variations of cancer worldwide, even in low-middle-income countries (LMICs) [1]. Despite advances in diagnosing and treating this disease, lung cancer prevalence and mortality have increased. A...	{"introduction": "Lung cancer has progressed to be one of the most frequent and deadly variations of cancer worldwide, even in low-middle-income countries (LMICs) [1]. Despite advances in diagnosing and treating this disease, lung cancer prevalence and mortality have increased. According to the last report of The Globa...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10005169	Spectral imaging enables contrast agent–free real-time ischemia monitoring in laparoscopic surgery	[ "Lena Maier-Hein", "Dogu Teber", "Annette Kopp-Schneider", "Brittaney Everitt", "Sebastian Pirmann", "Minu Tizabi", "Diana Mindroc", "Nicholas Schreck", "Manuel Wiesenfarth", "Anant Vemuri", "Sebastian Baron", "Pia Bader", "Matthias Bodenbach", "Alexey Aksenov", "Jan Sellner", "Alexand...	Laparoscopic surgery has evolved as a key technique for cancer diagnosis and therapy. While characterization of the tissue perfusion is crucial in various procedures, such as partial nephrectomy, doing so by means of visual inspection remains highly challenging. We developed a laparoscopic real-time multispectral imagi...	10.1126/sciadv.add6778	[]	[{"citation_id": "R1", "related_text": ["A common necessity of laparoscopic surgeries, for example, is stopping the blood flow to a specific organ or tissue region by clamping the arteries responsible for blood supply. This process, commonly referred to as ischemia induction, prevents excessive bleeding of patients (1)...	{"introduction": "Replacing traditional open surgery with minimally invasive techniques for complicated interventions such as tumor resection is one of the most important challenges in modern health care. Conventionally used RGB (red, green, and blue) camera-based laparoscopes, however, are ill-suited for these demands...	[{"id": "", "caption": "We recorded two MSI sequences [perfused1 (for training) and perfused2 (for testing)] before the clamp was applied to the renal artery and one sequence after applying the clamp (for testing). The laparoscope was removed and reinserted in the patient’s abdominal cavity before recording the testing...	[{"caption": "ccRCC, clear cell renal cell carcinoma; PRCC, papillary renal cell carcinoma; ChRCC, chromophobe renal cell carcinoma; BMI, body mass index.", "content": "<table frame=\"hsides\" rules=\"groups\"><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><col width=\"%\" spa...
PMC10005935	Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium	[ "Esther Walton", "Danai Dima", "Rosa Ayesa-Arriola", "James H. Cole", "Jessica Turner", "Theo G. M. van Erp", "Lianne Schmaal", "Paul M. Thompson", "Thomas Weickert", "Cynthia S. Weickert", "Aristotle Voineskos", "Daniela Vecchio", "Javier Vázquez-Bourgon", "Therese van Amelsvoort", "Dia...	Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study co...	10.1038/s41380-022-01897-w	[ "Neuroscience", "Schizophrenia" ]	[{"citation_id": "CR1", "related_text": ["Schizophrenia (SZ) is associated with an increased risk of premature mortality, with an average decrease in life expectancy of ~15 years [1–3]. This is partially accounted for by suicidal behaviour or accidental deaths, as well as poor somatic health, including cardiovascular a...	{"introduction": "Schizophrenia (SZ) is associated with an increased risk of premature mortality, with an average decrease in life expectancy of ~15 years [1–3]. This is partially accounted for by suicidal behaviour or accidental deaths, as well as poor somatic health, including cardiovascular and metabolic disease [4–...	[{"id": "", "caption": "Bivariate correlations are shown to provide an indication of the relative contribution of features in brain age prediction. The figure shows Pearson correlations between predicted brain age and cortical thickness features (top row), cortical surface areas (middle row) and subcortical volumes (bo...	[{"caption": "Clinical characteristics and brain-PAD in individuals with SZ.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Clinical parameter</th><th><italic>N</italic></th><th><italic>K</italic></th><th>beta</th><th>SE</th><th>95% CI</th><th><italic>P</italic><sub>FDR</sub> value</th></tr></the...
PMC10005939	Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data	[ "Frank R. Wendt", "Renato Polimanti", "Ronald Kessler", "Brendan A. Newton", "Andrea Quintero Reis" ]	Genome-wide association studies (GWAS) of suicidal thoughts and behaviors support the existence of genetic contributions. Continuous measures of psychiatric disorder symptom severity can sometimes model polygenic risk better than binarized definitions. We compared two severity measures of suicidal thoughts and behavior...	10.1038/s41380-022-01929-5	[ "Genetics", "Depression" ]	[{"citation_id": "CR1", "related_text": ["Death by suicide is responsible for more than 700,000 deaths per year [1]. The World Health Organization invested in global advocacy and awareness programs toward reducing stigma and increasing access to care. However, death by suicide ranks as the fourth leading cause of death...	{"introduction": "Death by suicide is responsible for more than 700,000 deaths per year [1]. The World Health Organization invested in global advocacy and awareness programs toward reducing stigma and increasing access to care. However, death by suicide ranks as the fourth leading cause of death among teens and young a...	[{"id": "", "caption": "A Linear relationships between suicidality and S-factor polygenic scores estimated using European ancestry GWAS summary association data in five diverse ancestry groups. B Portability of suicidality and S-factor polygenic scores into Admixed American suicidality data from the UK Biobank. Asteris...	[]
PMC10005942	Inflammation and cognition in severe mental illness: patterns of covariation and subgroups	[ "Torill Ueland", "Ole Andreas Andreassen", "Ingrid Melle", "Nils Eiel Steen", "Trine Vik Lagerberg", "Monica Bettina Elkjaer Greenwood Ormerod", "Christine Mohn", "Daniel Roelfs", "Pål Aukrust", "Srdjan Djurovic", "Attila Szabo", "Luigi Angelo Maglanoc", "Beathe Haatveit", "Thor Ueland", ...	A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cogn...	10.1038/s41380-022-01924-w	[ "Bipolar disorder", "Molecular biology", "Schizophrenia" ]	[{"citation_id": "CR1", "related_text": ["Schizophrenia (SZ) and bipolar (BD) spectrum disorders are complex severe mental illnesses (SMI) with shared genetic risk factors and neurobiological mechanisms [1]. Cognitive impairments are prevalent and considered a core feature of SMI [2]. These deficits may precede the ons...	{"introduction": "Schizophrenia (SZ) and bipolar (BD) spectrum disorders are complex severe mental illnesses (SMI) with shared genetic risk factors and neurobiological mechanisms [1]. Cognitive impairments are prevalent and considered a core feature of SMI [2]. These deficits may precede the onset of mental illness [3–...	[{"id": "", "caption": "A Percentage of SZ, BD and HC in cluster 1 and cluster 2. B Boxplots showing differences between the subgroup cluster 1 and cluster 2 on the cognitive domains and inflammatory/immune markers identified from the CCA.", "related_text": "The first cluster identified a subgroup of participants (tota...	[{"caption": "Differences between subgroups on demographic and clinical data.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th /><th>Cluster 1 (<italic>N</italic> = 625)</th><th>Cluster 2 (<italic>N</italic> = 777)</th><th><italic>p</italic> value<sup>a</sup></th><th>95% CI<sup>b</sup></th><th>Clus...
PMC10006437	Assessment of aerosol persistence in ICUs via low-cost sensor network and zonal models	[ "I. Novosselov", "J. G. Hecker", "S. Teng", "R. Rochlin", "J. He", "K. Glenn" ]	The COVID-19 pandemic raised public awareness about airborne particulate matter (PM) due to the spread of infectious diseases via the respiratory route. The persistence of potentially infectious aerosols in public spaces and the spread of nosocomial infections in medical settings deserve careful investigation; however,...	10.1038/s41598-023-30778-7	[ "Engineering", "Health occupations", "Health care", "Environmental sciences" ]	[{"citation_id": "CR1", "related_text": ["Nosocomial infections can occur during the patient's stay in the hospital or after visits to medical facilities. Many of these diseases can be transmitted through the respiratory route, associated with exposure to airborne microparticles generated by coughing, sneezing, talking...	{"introduction": "Nosocomial infections can occur during the patient's stay in the hospital or after visits to medical facilities. Many of these diseases can be transmitted through the respiratory route, associated with exposure to airborne microparticles generated by coughing, sneezing, talking, aerosol-generating med...	[{"id": "", "caption": "Normalized time data from ICU 1 showing aerosol concentration for each zone. Left: Zones compared to background levels. Right: Normalized average data with decay rate starting 60 s after the end of nebulization. The higher horizontal line represents the value of A, or the normalized value of aer...	[{"caption": "Percentage of aerosols dispersed to each location (inside the room, under the doorway, and at the nursing station) after aerosolization.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\" rowspan=\"2\">ICU</th><th align=\"left\" colspan=\"3\">Negative Pressure</th><th ali...
PMC10007007	Artificial Intelligence–Based Chatbots for Promoting Health Behavioral Changes: Systematic Review	[ "Shan Qiao", "Xiaoming Li", "Dezhi Wu", "Cheuk Chi Tam", "Abhishek Aggarwal" ]	Artificial intelligence (AI)–based chatbots can offer personalized, engaging, and on-demand health promotion interventions. The aim of this systematic review was to evaluate the feasibility, efficacy, and intervention characteristics of AI chatbots for promoting health behavior change. A comprehensive search was conduc...	10.2196/40789	[ "mobile phone", "acceptability", "usability", "feasibility", "intervention", "efficacy", "engagement", "health behavior change", "AI", "artificial intelligence", "chatbot" ]	[{"citation_id": "ref1", "related_text": ["Artificial intelligence (AI)–driven chatbots (AI chatbots) are conversational agents that mimic human interaction through written, oral, and visual forms of communication with a user [1,2]. With the increased access to technological devices (eg, smartphones and computers) and ...	{"introduction": "Artificial intelligence (AI)–driven chatbots (AI chatbots) are conversational agents that mimic human interaction through written, oral, and visual forms of communication with a user [1,2]. With the increased access to technological devices (eg, smartphones and computers) and the internet, AI chatbots...	[{"id": "", "caption": "Eligibility screening process. AI: artificial intelligence.", "related_text": "A total of 1961 articles were initially retrieved and screened based on these criteria. Finally, 15 articles met the inclusion criteria and were selected for this review (Figure 1). Disagreements in selection were res...	[{"caption": "Characteristics of the reviewed studies (N=15).", "content": "<table frame=\"hsides\" rules=\"groups\" width=\"1000\" cellpadding=\"5\" cellspacing=\"0\" border=\"1\"><col width=\"110\" span=\"1\" /><col width=\"150\" span=\"1\" /><col width=\"190\" span=\"1\" /><col width=\"120\" span=\"1\" /><col width=...
PMC10008430	Efficacy and safety of acupuncture for postpartum hypogalactia: protocol for a systematic review and meta-analysis	[ "Fan-Rong Liang", "Zhen-Yong Zhang", "Hong-Bin Zhao", "Qiu Bi", "Zi-Han Yin", "Yuan-Fang Zhou", "Qiong-Nan Bao" ]	Breast milk is recognised as the best natural food for neonates, but many women experience postpartum hypogalactia (PH). Randomised trials have found that acupuncture exert therapeutic effect on women with PH. However, systematic reviews on the efficacy and safety of acupuncture are still lacking; therefore, this syste...	10.1136/bmjopen-2022-068224	[ "Protocols & guidelines", "OBSTETRICS", "COMPLEMENTARY MEDICINE" ]	[{"citation_id": "R1", "related_text": ["Postpartum hypogalactia (PH) is a common condition that greatly affects healthy growth and development of babies. It is characterised by little or no breast milk during the lactation period. The WHO recommended that infants should be exclusively breastfed in the first 6 months.1...	{"introduction": "Postpartum hypogalactia (PH) is a common condition that greatly affects healthy growth and development of babies. It is characterised by little or no breast milk during the lactation period. The WHO recommended that infants should be exclusively breastfed in the first 6 months.1 However, only 38% of i...	[{"id": "", "caption": "Flow diagram of the study selection process.", "related_text": "First, all retrieved articles will be imported into EndNote (V.X9). After removing duplicates, two reviewers (Q-NB and Y-FZ) will independently screen the titles and abstracts of all studies to filter out articles that meet the incl...	[{"caption": "Search strategy for PubMed", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">No.</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Search terms</td></tr></thead><tbody><tr><td align=\"left\" valign=\"top\" ...
PMC10008455	Difficult-to-treat rheumatoid arthritis (D2T RA): clinical issues at early stages of disease	[ "Lydia Abasolo", "Benjamin Fernandez-Gutierrez", "Zulema Rosales", "Dalifer Freites Nuñez", "Marta Novella-Navarro", "Isidoro González-Álvaro", "Patricia Lopez-Viejo", "Alfredo Madrid-Garcia", "Leticia Leon" ]	Most studies on difficult-to-treat rheumatoid arthritis (D2T RA) have focused on established RA. Here, we analyse whether disease activity in the early stages of RA could influence progression to a D2T RA under real-life conditions. Other clinical and treatment-related factors were also analysed. A longitudinal multice...	10.1136/rmdopen-2022-002842	[ "Biological Therapy", "Outcome Assessment, Health Care", "Arthritis, Rheumatoid" ]	[{"citation_id": "R1", "related_text": ["The main therapeutic objective in rheumatoid arthritis (RA) is to prevent joint damage and disability. Treatment seeks to achieve and maintain ‘remission’ or, at least, minimal disease activity. Recent changes in the management of RA have improved the clinical course of the dise...	{"introduction": "The main therapeutic objective in rheumatoid arthritis (RA) is to prevent joint damage and disability. Treatment seeks to achieve and maintain ‘remission’ or, at least, minimal disease activity. Recent changes in the management of RA have improved the clinical course of the disease.1 The ‘window of op...	[{"id": "", "caption": "Number of patients who met each of the three D2T RA criteria. b/tsDMARDs, biological or targeted synthetic disease-modifying antirheumatic drugs; D2T RA, difficult-to-treat rheumatoid arthritis; csDMARD, conventional synthetic disease-modifying antirheumatic drugs.", "related_text": "Interesting...	[{"caption": "Multivariate regression analysis", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">\n<break />\n</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">OR</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" c...
PMC10008474	Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis	[ "Shu-Yuan Liu", "Yanling Huang", "Chen-Shi Lin", "Li-Zhen Dai", "Yu-Hao Lin", "Hong Ma" ]	To compare the efficacy and safety between and within glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT-2is) in overweight or obese adults with or without diabetes mellitus. PubMed, ISI Web of Science, Embase and Cochrane Central Register of Controlled Trials datab...	10.1136/bmjopen-2022-061807	[ "Diabetes & endocrinology", "General diabetes", "DIABETES & ENDOCRINOLOGY" ]	[{"citation_id": "R1", "related_text": ["The WHO claimed that obesity has become a major public health challenge of the 21st century.1 Obesity can cause considerable harm to affect individuals notable, including physical disabilities, psychological problems, increasing the risk of expanding sets of chronic diseases, su...	{"introduction": "The WHO claimed that obesity has become a major public health challenge of the 21st century.1 Obesity can cause considerable harm to affect individuals notable, including physical disabilities, psychological problems, increasing the risk of expanding sets of chronic diseases, such as diabetes mellitus...	[{"id": "", "caption": "Network meta-analysis results among active treatment. (A) Serious adverse events; (B) discontinuation due to adverse events. CANA, canagliflozin; DAPA, dapagliflozin; DUL, dulaglutide; EMPA, empagliflozin; EXE, exenatide; LIR, liraglutide; SEM, semaglutide.", "related_text": "Pairwise meta-analy...	[]
PMC10009453	Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study	[ "Joshua A. Bell", "Emma L. Anderson", "Eleanor Sanderson", "George Davey Smith", "Michael V. Holmes", "Caroline J. Bull", "Madeleine L. Smith" ]	Type 2 diabetes (T2D) and coronary artery disease (CAD) both have known genetic determinants, but the mechanisms through which their associated genetic variants lead to disease onset remain poorly understood. We used large-scale metabolomics data in a two-sample reverse Mendelian randomization (MR) framework to estimat...	10.1016/j.ebiom.2023.104503	[ "NMR, Nuclear magnetic resonance", "LD, Linkage disequilibrium", "SNP, Single nucelotide polymorphism", "GWAS, Genome wide association studies", "VLDL-C, Very low density lipoprotein cholesterol", "HDL-C, High density lipoprotein cholesterol", "LDL-C, Low density lipoprotein cholesterol", "BCAA, Branc...	[{"citation_id": "bib1", "related_text": ["Globally, overall incidence rates of type 2 diabetes (T2D) and coronary artery disease (CAD) are increasing in parallel, together affecting over 500 million adults.1,2 Both diseases have roots in disordered metabolism, but they differ in their life course development and clini...	{"evidence before this study": "We searched Medline for epidemiological and Mendelian randomization (MR) studies containing the terms ‘type 2 diabetes’ or ‘coronary artery disease’, and ‘metabolomic’ or ‘metabolites’, among any human population, without date restrictions. Previous cross-sectional and MR studies have id...	[{"id": "", "caption": "Comparison of the effects of T2D and CAD liability on adiposity, metabolic traits (those included in Fig. 1, Fig. 2, Fig. 3, Fig. 4), medication use, smoking and alcohol use. Effect estimates are SD unit differences in adiposity or metabolic trait, or log odds for medication use and smoking/alco...	[]
PMC10009463	Effectiveness and safety of acupuncture for insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis	[ "Jiao Chen", "Tian-Yu Wu", "Jin-Qun Hu", "Hua-Ying Fan", "Yu Liu" ]	To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate acupuncture's clinical effect on insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). PubMed, Cochrane Library, Embase databases, and Chinese databases, including China National Knowledge Infrastructur...	10.1016/j.heliyon.2023.e13991	[ "Meta-analysis", "Metformin", "Insulin resistance", "Polycystic ovary syndrome", "Acupuncture" ]	[{"citation_id": "bib1", "related_text": ["Polycystic ovary syndrome (PCOS), a complex endocrine and metabolic disorder, is characterized by androgen excess (hirsutism and/or hyperandrogenemia) and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology). To date, its pathogenesis remains unclear. How...	{"introduction": "Polycystic ovary syndrome (PCOS), a complex endocrine and metabolic disorder, is characterized by androgen excess (hirsutism and/or hyperandrogenemia) and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology). To date, its pathogenesis remains unclear. However, insulin resistance ...	[{"id": "", "caption": "Comparison of relative risk of adverse events according to intervention.", "related_text": "Pooled analysis of two studies showed no significant difference in the RR of adverse events with combination treatment compared with medicine alone (RR, 0.80; 95% CI, 0.51 to 1.25; P = 0.32; Fig. 9), with...	[{"caption": "Assessment according to the GRADE system.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th rowspan=\"2\">Type</th><th rowspan=\"2\">Outcome</th><th colspan=\"5\">Certainty assessment<hr /></th><th rowspan=\"2\">Certainty of the evidence (GRADE)</th></tr><tr><th>Risk of bias</th><th>In...
PMC10009811	Small-Sample Estimation of the Mutational Support and Distribution of SARS-CoV-2	[ "Olgica Milenkovic", "Jianhao Peng", "Eli Chien", "Vishal Rana" ]	We consider the problem of determining the mutational support and distribution of the SARS-CoV-2 viral genome in the small-sample regime. The mutational support refers to the unknown number of sites that may eventually mutate in the SARS-CoV-2 genome while mutational distribution refers to the distribution of point mut...	10.1109/TCBB.2022.3165395	[ "virology", "Good-Turing estimators", "Chebyshev and weighted Chebyshev approximations", "small-sample distribution estimation", "Small-sample support estimation" ]	[{"citation_id": "ref1", "related_text": ["Viruses mutate due to unreliable replication of their genetic content and their need to evolve, adapt and evade the immune system of the host organism. As viruses accumulate mutations, some of them may become advantageous to the survival of the virus and help it circulate more...	{"introduction": "Viruses mutate due to unreliable replication of their genetic content and their need to evolve, adapt and evade the immune system of the host organism. As viruses accumulate mutations, some of them may become advantageous to the survival of the virus and help it circulate more widely in the host popul...	[{"id": "", "caption": "The probability of mutations at six substitution sites in the S region of the UK variant obtained using the GT and ML estimators.", "related_text": "The outlined distribution estimation procedure may also be important in terms of predicting growth trends for certain mutations that may not be eas...	[{"caption": "", "content": "<table xmlns:ns0=\"http://www.w3.org/1998/Math/MathML\" xmlns:ns1=\"http://www.w3.org/1999/xlink\" frame=\"box\" rules=\"all\" cellpadding=\"5\"><colgroup span=\"1\"><col span=\"1\" /><col span=\"1\" /><col span=\"1\" /><col span=\"1\" /><col span=\"1\" /><col span=\"1\" /><col span=\"1\" /...
PMC10009838	Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study	[ "Thomas Harder", "Ole Wichmann", "Lars Schaade", "Thomas Grünewald", "Dominik Huster", "Guntram Lock", "Matthias Janneck", "Annette Reichardt", "Ammar Ghouzi", "Alexander Peric", "Caroline Isner", "Helmut Schühlen", "Sven Gläser", "Eberhard Hildt", "Laura Werel", "Sascha Hein", "Brig...	COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave. We analyzed data from 276 ...	10.1007/s15010-023-02012-z	[ "Omicron", "SARS-CoV-2", "Case-control study", "Hospitalization", "Vaccine effectiveness", "COVID-19" ]	[{"citation_id": "CR1", "related_text": ["The SARS-CoV-2 pandemic spread globally since December 2019 with more than 600 million cumulative cases and 6.8 million deaths documented by the end of January 2023 [1]. Several different variants of the virus evolved over time. In Germany, the Alpha and Delta variants dominate...	{"introduction": "The SARS-CoV-2 pandemic spread globally since December 2019 with more than 600 million cumulative cases and 6.8 million deaths documented by the end of January 2023 [1]. Several different variants of the virus evolved over time. In Germany, the Alpha and Delta variants dominated in 2021. In November 2...	[{"id": "", "caption": "Time between last vaccine dose and symptom onset: vaccine effectiveness for different time intervals", "related_text": "When VE estimates were stratified according to time interval between last vaccine dose and date of symptom onset, we observed no significant differences between VE values, indi...	[{"caption": "Prior infections and in temporal context with vaccination", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\" /><th align=\"left\" colspan=\"2\">No prior infection</th><th align=\"left\" colspan=\"2\">Unvaccinated with prior infection(s)</th><th align=\"left\" colspan=\"2\...
PMC10010178	Modelling quarantine effects on SARS-CoV-2 epidemiological dynamics in Chilean communes and their relationship with the Social Priority Index	[ "Mauricio O. Gallardo", "M. Leonor Bustamante", "Dino G. Salinas" ]	An epidemiological model (susceptible, un-quarantined infected, quarantined infected, confirmed infected (SUQC)) was previously developed and applied to incorporate quarantine measures and calculate COVID-19 contagion dynamics and pandemic control in some Chinese regions. Here, we generalized this model to incorporate ...	10.7717/peerj.14892	[ "Confirmed infected cases", "Social priority index", "Social distancing", "SARS-CoV-2", "Lockdown", "Quarantine", "Social inequality", "Differential equations", "COVID-19", "Reproduction number" ]	[{"citation_id": "ref-1", "related_text": ["In SUQCR model, despite being in quarantine, the contacts within the household may be unavoidable, and given that quarantined individuals can also decide not to follow the instructions, generating offspring infections (Ashcroft, Lehtinen & Bonhoeffer, 2022; Kerr et al., 2021;...	{"introduction": "Mathematical models of the spread of infectious diseases can be very useful for monitoring and controlling epidemics when such models use and predict the number of infected people. These figures are frequently reported by health authorities during a pandemic, as in the current coronavirus (COVID-19) p...	[{"id": "", "caption": "The graphs indicate the regression equations and the square of the Pearson’s correlation coefficient (r2) between the quarantine rate (γ [day−1]) and the social priority index (SPI for communes in 2020) of the study communes. (A) Without quarantine imposed by the health authorities (stage 1). (B...	[{"caption": "In total, 32 communes were studied in the province of Santiago, Chile. The continuous interval of days corresponding to stages 1 and 2 was extended for all communes from March 30 to June 15, 2020 (Supplementary File S2). The number of inhabitants (N) and the social priority index (SPI) are also shown for ...
PMC10010343	Repurposing Azacitidine and Carboplatin to Prime Immune Checkpoint Blockade–resistant Melanoma for Anti-PD-L1 Rechallenge	[ "Nikola A. Bowden", "Ricardo E. Vilain", "Adeeb Majid", "Richard Levy", "Leanna Pugliese", "Shu Ren", "Kerrie Cornall", "Jason W. H. Wong", "Xiaoqiang Zhu", "Moira C. Graves", "Megan Lyle", "Andre van der Westhuizen" ]	Drug repurposing offers the opportunity for chemotherapy to be used to reestablish sensitivity to immune checkpoint blockade (ICB) therapy. Here we investigated the clinical and translational aspects of an early phase II study of azacitidine and carboplatin priming for anti-PDL1 immunotherapy (avelumab) in patients wit...	10.1158/2767-9764.CRC-22-0128	[]	[{"citation_id": "bib1", "related_text": ["Despite significant progress in the treatment of metastatic melanoma with molecularly targeted and immune checkpoint blockade (ICB) therapy in recent years, there remains limited effective treatment once resistance occurs. The mechanisms of resistance to ICB are being extensiv...	{"introduction": "Despite significant progress in the treatment of metastatic melanoma with molecularly targeted and immune checkpoint blockade (ICB) therapy in recent years, there remains limited effective treatment once resistance occurs. The mechanisms of resistance to ICB are being extensively explored, and recentl...	[{"id": "", "caption": "T-cell exhaustion proliferation and migration markers. Flow cytometry was used to quantify markers from peripheral blood at baseline, week 9 after two cycles of azacitidine and carboplatin and week 22 after six cycles of avelumab.", "related_text": "T-cell exhaustion proliferation and migration ...	[{"caption": "TRAEs", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" span=\"1\" /><col align=\"left\" span=\"1\" /><col align=\"left\" span=\"1\" /><col align=\"left\" span=\"1\" /><col align=\"left\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" cols...
PMC10010347	Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry	[ "Clayton Yates", "Damali N. Martin", "Folake T. Odedina", "Windy Dean-Colomb", "Solomon O. Rotimi", "Kathryn R. Brignole", "Moray J. Campbell", "Paz Polak", "Melissa Davis", "Wei Tang", "Stefan Ambs", "Isra Elhussin", "Balasubramanyam Karanam", "Olabode P. Oluwole", "Omolara A. Fatiregun...	In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to compare genomic mutations with African American (AA) and European American (EA) The Cancer Genome Atlas (TCGA) prostate cancer. NG samples wer...	10.1158/2767-9764.CRC-22-0136	[]	[{"citation_id": "bib1", "related_text": ["For men, adenocarcinoma of the prostate is the most frequently diagnosed cancer, accounting, globally, for an estimated 1,414,259 cases and 375,304 deaths in 2020. The preponderance of this mortality is for men of African ancestry (MAA), including African American (AA), Centra...	{"introduction": "For men, adenocarcinoma of the prostate is the most frequently diagnosed cancer, accounting, globally, for an estimated 1,414,259 cases and 375,304 deaths in 2020. The preponderance of this mortality is for men of African ancestry (MAA), including African American (AA), Central American, Caribbean, an...	[{"id": "", "caption": "Prostate cancer somatic variants within known prostate cancer–associated genes. A, Variant calling within the NG cohort (n = 45) produced 1,168,250 variants. A total of 25 genes were known to be associated with prostate cancer harbored variants in at least two tumor samples. The most frequently ...	[]
PMC10010506	Incorporating algorithmic uncertainty into a clinical machine deep learning algorithm for urgent head CTs	[ "Ramon Gilberto González", "Synho Do", "Pamela W. Schaefer", "Julian He", "Javier M. Romero", "Sandra P. Rincon", "Otto Rapalino", "Hillary R. Kelly", "Shahmir C. Kamalian", "George J. Hunter", "Rajiv Gupta", "John Conklin", "John W. Chen", "Bradley R. Buchbinder", "Karen A. Buch", "Mi...	Machine learning (ML) algorithms to detect critical findings on head CTs may expedite patient management. Most ML algorithms for diagnostic imaging analysis utilize dichotomous classifications to determine whether a specific abnormality is present. However, imaging findings may be indeterminate, and algorithmic inferen...	10.1371/journal.pone.0281900	[]	[{"citation_id": "pone.0281900.ref001", "related_text": ["The application of artificial intelligence (AI) in neuroimaging has expanded with the potential to accelerate the accurate diagnosis of intracranial hemorrhage or other urgent intracranial abnormalities. Many machine-learning (ML) algorithms rely on dichotomous ...	{"introduction": "A patient with an urgent neurological abnormality requires prompt imaging. If the etiology is hemorrhage, immediate evacuation or treatment of an aneurysm may be lifesaving. If the cause is an ischemic stroke from a large vessel occlusion, thrombectomy can result in a favorable outcome. There are many...	[{"id": "", "caption": "A: Trace acute subarachnoid hemorrhage along the right anterior cingulate gyrus. B: Noncontrast head CT degraded by motion artifact. C: Normal noncontrast head CT.", "related_text": "The NP patient group included 168 scans (Fig 3). The largest portion of the scans was normal (n = 49, 29.2%, 22.7...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"center\" style=\"background-color:#D9D9D9\" rowspan=\"1\" colspan=\"1\">Case</th><th align=\"...
PMC10010521	The changing epidemiology of shigellosis in Australia, 2001–2019	[ "Martyn D. Kirk", "Rose Wright", "Danielle J. Ingle", "Benjamin G. Polkinghorne", "Deborah A. Williamson", "Kathryn Glass", "Aaliya F. Ibrahim" ]	Shigellosis is an increasing cause of gastroenteritis in Australia, with prolonged outbreaks reported in remote Aboriginal and Torres Strait Islander (hereafter “First Nations”) communities and among men who have sex with men (MSM) in major cities. To determine associations between Shigella species and demographic and ...	10.1371/journal.pntd.0010450	[]	[{"citation_id": "pntd.0010450.ref001", "related_text": ["Shigellosis is caused by gram-negative Shigella spp. bacteria, which is primarily transmitted through the faecal-oral route by direct or indirect contact with faecal matter [1]. There are four species of Shigella bacteria, characterised by their O antigen type a...	{"introduction": "Shigellosis is caused by gram-negative Shigella spp. bacteria, which is primarily transmitted through the faecal-oral route by direct or indirect contact with faecal matter [1]. There are four species of Shigella bacteria, characterised by their O antigen type and biochemical properties: S. dysenteria...	[{"id": "", "caption": "", "related_text": "Indigenous status was available for 85% (15,529/18,327) of cases included in the analysis. There were higher rates of shigellosis among First Nations Australians when compared to the non-Indigenous population (Fig 5). Between 2016 and 2018 there was a greater than 3-fold incr...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10010531	Sexually transmitted infections among key populations in India: A protocol for systematic review	[ "Shanta Dutta", "Rajatsuvra Adhikary", "Bhumika Tumkur Venkatesh", "Subrata Biswas", "Abhisek Royal", "Santhakumar Aridoss", "Papiya Banerji", "Piyali Ghosh", "Utsha Ghosh", "Agniva Majumdar", "Mihir Bhatta" ]	Sexually transmitted infections (STIs) are one of the leading causes of health, and economic burdens in the developing world, leading to considerable morbidity, mortality, and stigma. The incidence and prevalence of the four curable STIs viz. syphilis, gonorrhoea, chlamydia, and trichomoniasis vary remarkably across di...	10.1371/journal.pone.0279048	[]	[{"citation_id": "pone.0279048.ref001", "related_text": ["According to a recent estimate by World Health Organization (WHO), approximately three hundred seventy million new sexually transmitted infections (STIs) occur each year around the world, and almost half of the infected individuals are young in their age [1]. Fo...	{"introduction": "According to a recent estimate by World Health Organization (WHO), approximately three hundred seventy million new sexually transmitted infections (STIs) occur each year around the world, and almost half of the infected individuals are young in their age [1]. For the suitable planning and execution of...	[]	[]
PMC10010533	The spatial and temporal distribution of SARS-CoV-2 from the built environment of COVID-19 patient rooms: A multicentre prospective study	[ "Derek R. MacFadden", "Rees Kassen", "Nicole Harris-Linton", "Caroline Nott", "Alex Wong", "John Lapp", "Jason Moggridge", "Lydia Xing", "David S. Guttman", "Hebah S. Mejbel", "Aaron Hinz", "Madison Burella", "Michael Fralick" ]	SARS-CoV-2 can be detected from the built environment (e.g., floors), but it is unknown how the viral burden surrounding an infected patient changes over space and time. Characterizing these data can help advance our understanding and interpretation of surface swabs from the built environment. We conducted a prospectiv...	10.1371/journal.pone.0282489	[]	[{"citation_id": "pone.0282489.ref001", "related_text": ["SARS-CoV-2 primarily spreads via aerosols and droplets, and the degree of aerosolization is related to multiple factors, including ventilation [1–4]. Within the built environment, the floor is the most common location where the virus can be detected [5–9]. Floor...	{"introduction": "SARS-CoV-2 primarily spreads via aerosols and droplets, and the degree of aerosolization is related to multiple factors, including ventilation [1–4]. Within the built environment, the floor is the most common location where the virus can be detected [5–9]. Floors likely act as a “sink,” collecting the...	[{"id": "", "caption": "m = metre. Distance was measured from the patient’s bed, with 3 m indicating where the room connected with the hallway (typically 3 m to 5 m from the patient’s bed). Points show the patient room means of log10 viral copies from all the positive swabs collected (negative results were excluded fro...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10010538	The burden of mortality due to injury in Cabo Verde, 2018	[ "Lara Ferrero Gomez", "Maria da Luz Lima Mendonça", "Ngibo Mubeta Fernandes" ]	External causes continue to be one of the main causes of mortality in the world and Cabo Verde is no exception. Economic evaluations can be used to demonstrate the disease burden of public health problems such as injuries and external causes and support prioritization of interventions aimed at improving the health of t...	10.1371/journal.pone.0278589	[]	[{"citation_id": "pone.0278589.ref001", "related_text": ["The world loses nearly five million people annually to trauma, poisoning and other external causes, which corresponds to 9% of global deaths [1]. Injuries continue to have significant weight on the global disease burden, and are among the main causes of morbidit...	{"introduction": "The world loses nearly five million people annually to trauma, poisoning and other external causes, which corresponds to 9% of global deaths [1]. Injuries continue to have significant weight on the global disease burden, and are among the main causes of morbidity and mortality in adolescents, young pe...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10011014	Cervical and systemic innate immunity predictors of HIV risk linked to genital herpes acquisition and time from HSV-2 seroconversion	[ "Raina Nakova Fichorova", "Gustavo F Doncel", "Robert Salata", "Robert Barbieri", "Sharon Anderson", "Tsungai Chipato", "Hidemi Yamamoto", "Xiaoming Gao", "Pai-Lien Chen", "Charles S Morrison", "Yashini Govender" ]	To examine innate immunity predictors of HIV-1 acquisition as biomarkers of HSV-2 risk and biological basis for epidemiologically established HIV-1 predisposition in HSV-2 infected women. We analysed longitudinal samples from HIV-1 negative visits of 1019 women before and after HSV-2 acquisition. We measured cervical a...	10.1136/sextrans-2022-055458	[ "HIV", "herpes genitalis", "women", "inflammation", "infection" ]	[{"citation_id": "R1", "related_text": ["The significance of herpes simplex virus-2 (HSV-2) as a risk factor for HIV is driven by the high HSV-2 prevalence worldwide and in the Sub-Saharan HIV epicentre (estimated 39.3%−83.3% in South African women).1 Women and men infected with HSV-2 have estimated 3-fold higher HIV a...	{"introduction": "The significance of herpes simplex virus-2 (HSV-2) as a risk factor for HIV is driven by the high HSV-2 prevalence worldwide and in the Sub-Saharan HIV epicentre (estimated 39.3%−83.3% in South African women).1 Women and men infected with HSV-2 have estimated 3-fold higher HIV acquisition.2 A 3.2-fold...	[{"id": "", "caption": "Forest plot of estimated ORs and 95% CIs of HSV-2 and HIV-1 acquisition for levels of imbalanced systemic and cervical immunity assessed 3 months prior to the HSV-2 or HIV-1 seroconversion visit. Only biomarkers or biomarker combinations significantly predicting either one or both viral infectio...	[{"caption": "Differences in levels* of cervical and systemic biomarkers by HSV-2 infection status adjusted for covariates", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" colspan=\"2\" rowspan=\"1\" /><td align=\"left\" valign=\"bottom\" colspan=\"3\" rowspan=\"1\"...
PMC10011028	Projection of healthcare demand in Germany and Switzerland urged by Omicron wave (January–March 2022)	[ "Harald Renz", "Sabine Feig", "Orestis Loukas", "Ho Ryun Chung", "Doortje Engel", "Martin Bühler", "Alexa Caduff", "Ivan Lunati", "Noé Stauffer", "Hossein Gorji" ]	In January 2022, after the implementation of broad vaccination programs, the Omicron wave was propagating across Europe. There was an urgent need to understand how population immunity affects the dynamics of the COVID-19 pandemic when the loss of vaccine protection was concurrent with the emergence of a new variant of ...	10.1016/j.epidem.2023.100680	[ "Covid-19", "Healthcare demand", "Mitigation measures", "Epidemiological modeling" ]	[{"citation_id": "b1", "related_text": ["The subsequent official reports on the epidemiological situations turned out to support the described short-term predictions formulated on the basis of the simulated realistic scenarios; thereby the model forecasts were in general consistent with the actual development of the pa...	{"introduction": "The Omicron variant (B.1.1.529) has become the globally dominant SARS-CoV-2 strain within two months from its identification in South Africa and the designation as a variant-of-concern by the World Health Organization (WHO).1 Its initial rapid spread across the South African province of Gauteng led to...	[{"id": "", "caption": "Evaluation of projected Omicron scenarios in Germany for (b) daily incidence, (d) 7-day averaged incidence, and (f) ICU occupancy. The official reported data (Robert Koch Institute, 2021a) are indicated by bars. They are also shown over a longer period of time for (a) daily incidence, (c) 7-day ...	[{"caption": "Hospitalization initial data of Germany (as of January 17, 2022) (Robert Koch Institute, 2021a).", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\" /><th align=\"left\">Estimate used in the model</th><th align=\"left\">Corrected value</th></tr></thead><tbody><tr><td align...
PMC10011442	Segmentation stability of human head and neck cancer medical images for radiotherapy applications under de-identification conditions: Benchmarking data sharing and artificial intelligence use-cases	[ "Kimmo Kaski", "Clifton D. Fuller", "Antti Mäkitie", "Benjamin H. Kann", "Renjie He", "Mohamed A. Naser", "Joel Jaskari", "Enrico Glerean", "Kareem A. Wahid", "Jaakko Sahlsten" ]	Demand for head and neck cancer (HNC) radiotherapy data in algorithmic development has prompted increased image dataset sharing. Medical images must comply with data protection requirements so that re-use is enabled without disclosing patient identifiers. Defacing, i.e., the removal of facial features from images, is o...	10.3389/fonc.2023.1120392	[ "defacing", "autosegmentation", "artificial intelligence (AI)", "medical imaging", "MRI", "head and neck cancer", "radiotherapy", "anonymization" ]	[{"citation_id": "B1", "related_text": ["The landscape of data democratization is rapidly changing. The rise of open science practices, inspired by coalitions such as the Center for Open Science (1), and the FAIR (Findable, Accessible, Interoperable, and Reusable) guiding principles (2), has spurred interest in public ...	{"introduction": "The landscape of data democratization is rapidly changing. The rise of open science practices, inspired by coalitions such as the Center for Open Science (1), and the FAIR (Findable, Accessible, Interoperable, and Reusable) guiding principles (2), has spurred interest in public data sharing. Subsequen...	[{"id": "", "caption": "The performance of models trained on the original data when evaluated on the original, mask_face, fsl_deface, or pydeface data for the six organs at risk included in the analysis. Only cases that were available for all the methods were included: 28 segmentations were used for all structures exce...	[{"caption": "Composite DSC performance - mean (standard deviation) - of all structures for all combinations of training data (rows) and evaluation data (columns).", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th valign=\"top\" align=\"left\" rowspan=\"1\" colspan=\"1\" /><th valign=\"top\" align=\...
PMC10011463	Baseline risk factors associated with immune related adverse events and atezolizumab	[ "G. Scott Chandler", "Vidya Maiya", "Laurent Essioux", "Rashad Rasul", "Gonzalo Durán-Pacheco", "Rajat Mohindra", "Katrin Madjar" ]	Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer patients in the last decade, but immune-related adverse events (irAEs) pose significant clinical challenges. Despite advances in the management of these unique toxicities, there remains an unmet need to further characterize the patient-leve...	10.3389/fonc.2023.1138305	[ "baseline risk factors", "immune-related adverse event", "toxicity", "anti-PDL1", "immune checkpoint inhibitor" ]	[{"citation_id": "B1", "related_text": ["The safety profile of anti-PD(L)1 therapies has been well documented (1–4). A recent systematic review found that patients treated with PD-(L)1 inhibitors developed irAEs at a rate of 74% (14% grade ≥3), those treated with CTLA-4 inhibitors at a rate of 89% (34% grade ≥3), and t...	{"introduction": "Immune checkpoint inhibitors (ICIs) have revolutionized the care of cancer patients, and these therapies are now the standard of care for treatment in multiple cancer indications. Treatment with ICIs may result in a unique form of toxicity related to the immunological mechanism of action and are commo...	[{"id": "", "caption": "Forest Plots of the country effect in patients with Asian ancestry (hazard ratio [HR] estimates and 95%-confidence intervals [CI]) adjusted for important confounders: age, BMI, sex and treatment. Each Asian country is compared against the group of all non-Asian countries (reference group). The e...	[{"caption": "Frequencies of irAEs (rash, hepatitis, pneumonitis, hypothyroidism, hyperthyroidism) of any grade per indication and treatment arm (atezolizumab monotherapy, atezolizumab combination, standard of care/control arms [chemotherapy or targeted therapy]).", "content": "<table frame=\"hsides\" rules=\"groups\">...
PMC10012092	Sex Differences in Depression and Sleep Disturbance as Inter-Related Risk Factors of Diabetes	[ "Shefali Chaudhary", "Rose Porta", "Clara S. Li" ]	Previous studies identified depression and sleep disturbance as risk factors for diabetes. Sleep disturbance and depression are known to be inter-related. Further, women relative to men are more prone to depression. Here, we investigated how depression and sleep disturbance may jointly influence the risk of diabetes an...	10.3389/fcdhc.2022.914451	[ "sex differences", "depression", "sleep", "risk factors", "diabetes" ]	[{"citation_id": "B1", "related_text": ["Over 34 million Americans, or more than 1 in 10, are diagnosed with diabetes, one of the most prevalent chronic diseases in the US, according to the Centers for Disease Control and Prevention, National Diabetes Statistics Report, 2020. Diabetes and related health problems have a...	{"introduction": "Over 34 million Americans, or more than 1 in 10, are diagnosed with diabetes, one of the most prevalent chronic diseases in the US, according to the Centers for Disease Control and Prevention, National Diabetes Statistics Report, 2020. Diabetes and related health problems have an enormous impact on US...	[{"id": "", "caption": "Predicted margins of diabetes with 95% confidence intervals with respect to (A) depression frequency, (B) nightly sleep hours, shown separately for males and females, and (C) depression at each level of sleep. Men relative to women showed stronger associations between depression frequency and ni...	[{"caption": "The effects of depression and sleep interaction with sex on the probability of diabetes (Model 1 and 2).", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th valign=\"top\" align=\"left\" rowspan=\"1\" colspan=\"1\">Variable</th><th valign=\"top\" align=\"center\" rowspan=\"1\" colspan=\"...
PMC10012856	Severity of maternal SARS-CoV-2 infection and perinatal outcomes of women admitted to hospital during the omicron variant dominant period using UK Obstetric Surveillance System data: prospective, national cohort study	[ "Marian Knight", "Jennifer J Kurinczuk", "Peter Brocklehurst", "Maria Quigley", "Patrick O'Brien", "Chris Gale", "Nigel A B Simpson", "Eddie Morris", "Kathryn Bunch", "Nicola Vousden", "Rema Ramakrishnan", "Hilde M Engjom" ]	To describe the severity of maternal infection when the omicron SARS-CoV-2 variant (B.1.1.529) was dominant (15 December 2021 to 14 March 2022) and describe outcomes by symptoms and vaccination status. Prospective, national cohort study using the UK Obstetric Surveillance System. 94 hospitals in the UK with a consultan...	10.1136/bmjmed-2022-000190	[ "Obstetrics", "Public health", "Infectious disease medicine", "Pregnancy complications", "COVID-19" ]	[{"citation_id": "R1", "related_text": ["In 2020, the World Health Organization’s living systematic review concluded that SARS-CoV-2 infection during pregnancy was associated with an increased risk of admission to intensive care for the mother, increased risk of preterm birth and admission for neonatal care for the inf...	{"introduction": "In 2020, the World Health Organization’s living systematic review concluded that SARS-CoV-2 infection during pregnancy was associated with an increased risk of admission to intensive care for the mother, increased risk of preterm birth and admission for neonatal care for the infant.1 Included studies ...	[{"id": "", "caption": "Inclusion flow chart of pregnant women admitted to hospital with SARS-CoV-2 infection, by admission group in the UK between 15 December 2021 and 14 March 2022", "related_text": "Of the 3699 women admitted with PCR confirmed SARS-CoV-2 infection between 15 December 2021 and 14 March 2022 (figure ...	[{"caption": "Perinatal outcomes among infants of women admitted with SARS-CoV-2 infection during the period when omicron was the dominant variant and who have given birth (n=2821) by symptom group and vaccination status in the UK during 15 December 2021 to 14 March 2022. Data are n (%)", "content": "<table frame=\"hsi...
PMC10013005	Comparison of Gait Speed Reserve, Usual Gait Speed, and Maximum Gait Speed of Adults Aged 50+ in Ireland Using Explainable Machine Learning	[ "Roman Romero-Ortuno", "Rose Anne Kenny", "Rossella Rizzo", "Belinda Hernández", "Orna A. Donoghue", "Silvin P. Knight", "James R. C Davis" ]	Gait speed is a measure of general fitness. Changing from usual (UGS) to maximum (MGS) gait speed requires coordinated action of many body systems. Gait speed reserve (GSR) is defined as MGS–UGS. From a shortlist of 88 features across five categories including sociodemographic, cognitive, and physiological, we aimed to...	10.3389/fnetp.2021.754477	[ "physiological", "walking", "gradient", "explainable", "reserve", "maximum", "speed", "gait" ]	[{"citation_id": "B1", "related_text": ["Similarly, TILDA work showed that slower recovery of BP after standing (systolic and/or diastolic) was independently associated with poorer gait performance (Briggs et al., 2020). On the other hand, a higher pulse interval indicates a higher heart rate variability and a more par...	{"introduction": "Gait speed is a measure of general fitness (Wu and Zhao, 2021); faster gait speed is associated with the ability to meet occupational demands in younger adults (Aldridge et al., 2020), whilst slower gait speed is associated with functional decline and morbidity in older adults (Bohannon, 1992; Kawajir...	[{"id": "", "caption": "Graphical summary of features selected for the three models. Features unique to a model are shown positioned around that model’s node. Features common to all models are positioned in the central ring of nodes; the legend for those five features is located below the UGS node. The remaining nodes ...	[{"caption": "Group statistics and results of independent samples Mann–Whitney U-test for historical and future falls and faints occurrence.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead valign=\"top\"><tr><th colspan=\"9\" align=\"left\" rowspan=\"1\">Historical falls and faints</th></tr></thead><tbody...
PMC10013358	A Systems-Based Framework for Immunisation System Design: Six Loops, Three Flows, Two Paradigms	[ "Stany Banzimana", "Kim De Boeck", "Nico Vandaele", "Catherine Decouttere" ]	Despite massive progress in vaccine coverage globally, the region of sub-Saharan Africa is lagging behind for Sustainable Development Goal 3 by 2030. Sub-national under-immunisation is part of the problem. In order to reverse the current immunisation system’s (IMS) underperformance, a conceptual model is proposed that ...	10.1080/20476965.2021.1992300	[ "problem structuring", "sustainability", "resilience", "sub-saharan africa", "immunisation", "System design" ]	[{"citation_id": "cit0001", "related_text": ["In order to develop this IMS model, a human-centred design and systems thinking approach was taken. Principles and tools such as causality and systems diagrams were applied to LMICs’ IMS to conceptually represent delays, feedback, and to identify key leverage points. Such a...	{"introduction": "Since the introduction of routine childhood immunisation in low-income-countries (LICs) in 1974 as the Expanded Program on Immunisation (EPI), a spectacular global decrease in neonatal mortality rate (NMR) and under-five mortality rate (U5MR) has been observed. However, the world-wide diphtheria-tetan...	[{"id": "", "caption": "Factors determining sustainability of the IMS: endogenous factors (green) and exogenous factors (blue). Exogenous resilience factors of the IMS are red.", "related_text": "In order to assess the long-term dominance of loops R1/R2/R3 and B1, the factors constraining them must be identified. This ...	[{"caption": "Examples of immunisation system leverage points classified according to Malhi et al. (2009) based on Meadows (1989).", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup><col width=\"1\" align=\"left\" /><col width=\"1\" align=\"left\" /></colgroup><thead><tr><th align=\"center\">Interventio...
PMC10013630	Understanding pediatric long COVID using a tree-based scan statistic approach: an EHR-based cohort study from the RECOVER Program	[ "Hanieh Razzaghi", "Grace M Lee", "L Charles Bailey", "Christopher B Forrest", "Yong Chen", "Priya Prahalad", "Patrick C Hanley", "Jason Block", "Seuli Bose-Brill", "Deepika Thacker", "Payal Patel", "Nathan M Pajor", "Asuncion Mejias", "Abigail Case", "Ravi Jhaveri", "Suchitra Rao", ...	Post-acute sequalae of SARS-CoV-2 infection (PASC) is not well defined in pediatrics given its heterogeneity of presentation and severity in this population. The aim of this study is to use novel methods that rely on data mining approaches rather than clinical experience to detect conditions and symptoms associated wit...	10.1093/jamiaopen/ooad016	[ "COVID-19", "post-acute sequelae of SARS-CoV-2 infection", "long COVID" ]	[{"citation_id": "ooad016-B1", "related_text": ["The National Institutions of Health (NIH) launched the new RECOVER initiative in 20211 to leverage electronic health record (EHR) data to better identify and characterize patients with post-acute sequelae of SARS-CoV-2 infection (PASC), defined by the NIH as failure to r...	{"introduction": "The National Institutions of Health (NIH) launched the new RECOVER initiative in 20211 to leverage electronic health record (EHR) data to better identify and characterize patients with post-acute sequelae of SARS-CoV-2 infection (PASC), defined by the NIH as failure to recover from COVID-19, or those ...	[{"id": "", "caption": "Significant branches of the R00–R09 block of the ICD hierarchy with nodes colored by percent excess cases.", "related_text": "Within the R00–R99 branch, the top 3 cuts were R00–R09 Symptoms and signs involving the circulatory and respiratory systems, R50–R69 General symptoms and signs and R40–R4...	[{"caption": "PASC vs COVID negative comparison TreeScan results", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col valign=\"top\" align=\"left\" span=\"1\" /><col valign=\"top\" align=\"left\" span=\"1\" /><col valign=\"top\" align=\"char\" char=\".\" span=\"1\" /><col valign=\"top\" alig...
PMC10013882	Attrition from HIV treatment after enrollment in a differentiated service delivery model: A cohort analysis of routine care in Zambia	[ "Sydney Rosen", "Brooke E. Nichols", "Priscilla Lumano Mulenga", "Mpande Mukumbwa-Mwenechanya", "Prudence Haimbe", "Hilda Shakwelele", "Muya Mwansa", "Anna Grimsrud", "Bevis Phiri", "Lise Jamieson", "Youngji Jo" ]	Many sub-Saharan Africa countries are scaling up differentiated service delivery (DSD) models for HIV treatment to increase access and remove barriers to care. We assessed factors associated with attrition after DSD model enrollment in Zambia, focusing on patient-level characteristics. We conducted a retrospective reco...	10.1371/journal.pone.0280748	[]	[{"citation_id": "pone.0280748.ref001", "related_text": ["Although access to antiretroviral treatment (ART) for HIV is now widespread, ART programs worldwide continue to face the challenge of retaining patients in lifelong care. Studies in sub-Saharan Africa (SSA) suggest that only 67% of patients remain in ART program...	{"introduction": "Although access to antiretroviral treatment (ART) for HIV is now widespread, ART programs worldwide continue to face the challenge of retaining patients in lifelong care. Studies in sub-Saharan Africa (SSA) suggest that only 67% of patients remain in ART programs after five years, with loss to follow-...	[{"id": "", "caption": "*Adjusted by age and facility level.", "related_text": "Other studies have also suggested that while DSD models may not improve retention among currently eligible patients, who are already “stable” at the time of DSD model enrollment and thus likely to continue to demonstrate high retention, it ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10013922	Maternal immunisation against Group B Streptococcus: A global analysis of health impact and cost-effectiveness	[ "Mark Jit", "Joy E. Lawn", "Caroline Trotter", "Raymond Hutubessy", "Artemis Koukounari", "Farah Seedat", "Jaya Chandna", "Proma Paul", "Bronner P. Gonçalves", "Simon R. Procter" ]	Group B Streptococcus (GBS) can cause invasive disease (iGBS) in young infants, typically presenting as sepsis or meningitis, and is also associated with stillbirth and preterm birth. GBS vaccines are under development, but their potential health impact and cost-effectiveness have not been assessed globally. We assesse...	10.1371/journal.pmed.1004068	[]	[{"citation_id": "pmed.1004068.ref001", "related_text": ["Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), is an important bacterial pathogen causing morbidity and mortality in pregnant women and their babies and is also increasingly recognised as a cause of disease in nonpregnant adults [1–3]. ...	{"introduction": "Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), is an important bacterial pathogen causing morbidity and mortality in pregnant women and their babies and is also increasingly recognised as a cause of disease in nonpregnant adults [1–3]. Invasive GBS (iGBS) disease in neonates ...	[{"id": "", "caption": "Threshold vaccine prices above $800 per dose are not shown. Least favourable normative assumptions were the use of an empirical CET, 3% discounting of QALYs, and exclusion of stillbirth QALYs. Most favourable assumptions were the use of 1 × GDP per capita CETs, 0% discounting of QALYs, and inclu...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10015103	Serologic responses to COVID-19 vaccination in children with history of multisystem inflammatory syndrome (MIS-C)	[ "Christina A. Rostad", "Ermias Belay", "Evan J. Anderson", "Ann Chahroudi", "Shana Godfred-Cato", "Teresa A. Hammett", "Yajira Beltran", "David A. Hunstad", "Federico R. Laham", "Carol M. Kao", "Austin T. Lu", "Laila Hussaini", "Nadine Baida", "Amber Kunkel", "Xuemin Chen", "Hui-Mien H...	Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTe...	10.1016/j.vaccine.2023.03.021	[]	[{"citation_id": "b0005", "related_text": ["Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a severe systemic inflammatory syndrome characterized by multiorgan involvement, myocardial dysfunction, shock, and occasionally death [1]. The pathophysiology of MIS-C is poorly understood, but...	{"introduction": "Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a severe systemic inflammatory syndrome characterized by multiorgan involvement, myocardial dysfunction, shock, and occasionally death [1]. The pathophysiology of MIS-C is poorly understood, but it is thought to represen...	[{"id": "", "caption": "SARS-CoV-2 antibody responses to Wuhan vs. Omicron (BA.1) variant in children post- BNT162b2 vaccine primary series. (A) Spike IgG (AU/mL); (B) Pseudovirus neutralizing antibodies (EC50); and (C) Antibody-dependent cell-mediated cytotoxicity (ADCC) antibody end-point titers are shown for childre...	[{"caption": "Baseline demographic characteristics of cohort.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th><bold>Variables</bold></th><th><bold>MIS-C</bold></th><th><bold>COVID-19</bold></th><th><bold>Healthy Controls</bold></th></tr></thead><tbody><tr><td><bold>Number (n)</bold></td><td>7</td>...
PMC10015119	Global research on syndemics: a meta-knowledge analysis (2001-2020)	[ "Ping Ma", "Banga Kamal Basu", "E. Lisako J. McKyer", "Helal Uddin Ahmed", "James N. Burdine", "Tamal Joyti Roy", "Tasmiah Nuzhath", "Samia Tasnim", "Tahmina Tasnim Rodela", "Nobonita Saha", "Md Mahbub Hossain" ]	Background: Syndemics or synergies of cooccurring epidemics are widely studied across health and social sciences in recent years. Methods: We conducted a meta-knowledge analysis of articles published between 2001 to 2020 in this growing field of academic scholarship. Results: We found a total of 830 articles authored b...	10.12688/f1000research.74190.2	[ "Syndemics; Multimorbidity; Health inequity; Health disparity; Health Promotion; Health Policy; Global Health; Meta-knowledge Analysis" ]	[{"citation_id": "ref1", "related_text": ["Addressing health inequities in marginalized populations requires a complex understanding of the epidemiological burden of multiple health problems and associated factors that determine the health statuses and outcomes in that context. 1 – 3 Theoretical frameworks may help in ...	{"introduction": "Addressing health inequities in marginalized populations requires a complex understanding of the epidemiological burden of multiple health problems and associated factors that determine the health statuses and outcomes in that context. 1 – 3 Theoretical frameworks may help in examining different dimen...	[{"id": "", "caption": "", "related_text": "An assessment of the cited references provided another perspective on how the current research publications cited and used previous scholarly items. Figure 7 represents the cited sources on the left, the most widely used keywords from the titles of cited publications in the m...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\" content-type=\"article-table\"><thead><tr><th align=\"left\" valign=\"top\" rowspan=\"1\" colspan=\"1\">Countries</th><th align=\"left\" valign=\"top\" rowspan=\"1\" colspan=\"1\">Number of publications</th><th align=\"left\" valign=\"top\" rowspan=\...
PMC10015671	Acceptability of a behavioural intervention to mitigate the psychological impacts of COVID-19 restrictions in older people with long-term conditions: a qualitative study	[ "Carolyn Chew-Graham", "Simon Gilbody", "David Ekers", "Dean McMillan", "Rebecca Woodhouse", "Eloise Ryde", "Lauren Burke", "Samantha Gascoyne", "Della Bailey", "Elizabeth Littlewood", "Liz Newbronner", "Andrew Henry", "Claire Sloan", "Peter A Coventry", "Leanne Shearsmith" ]	The COVID-19 pandemic heightened the need to address loneliness, social isolation and associated incidence of depression among older adults. Between June and October 2020, the Behavioural Activation in Social IsoLation (BASIL) pilot study investigated the acceptability and feasibility of a remotely delivered brief psyc...	10.1136/bmjopen-2022-064694	[ "QUALITATIVE RESEARCH", "Depression & mood disorders", "COVID-19" ]	[{"citation_id": "R1", "related_text": ["Loneliness is the subjective psychological expression of social isolation owing to dissatisfaction with the frequency and quality of social contacts.1 Social isolation is a quantifiable sense of reduced social network size and impoverished social contact.2 Loneliness is an incre...	{"introduction": "Loneliness is the subjective psychological expression of social isolation owing to dissatisfaction with the frequency and quality of social contacts.1 Social isolation is a quantifiable sense of reduced social network size and impoverished social contact.2 Loneliness is an increasing problem across al...	[]	[{"caption": "Overview of TFA domains", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Component</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Definition</td></tr></thead><tbody><tr><td align=\"left\" valign=\"top\"...
PMC10015672	Performance of digital early warning score (NEWS2) in a cardiac specialist setting: retrospective cohort study	[ "Amitava Banerjee", "Riyaz Patel", "Daniel Melley", "Tim Bonnici", "Baneen Alhmoud" ]	Patients with cardiovascular diseases (CVD) are at significant risk of developing critical events. Early warning scores (EWS) are recommended for early recognition of deteriorating patients, yet their performance has been poorly studied in cardiac care settings. Standardisation and integrated National Early Warning Sco...	10.1136/bmjopen-2022-066131	[ "health informatics", "risk management", "adult intensive & critical care", "adult cardiology", "COVID-19" ]	[{"citation_id": "R1", "related_text": ["Disease severity classification of patients with cardiovascular diseases (CVD) is challenging for nurses and physicians. Individuals with CVD can present with various sorts of critical events due to the disease’s pathophysiology or the comorbidities associated.1 The aetiology of...	{"introduction": "Disease severity classification of patients with cardiovascular diseases (CVD) is challenging for nurses and physicians. Individuals with CVD can present with various sorts of critical events due to the disease’s pathophysiology or the comorbidities associated.1 The aetiology of the disease and the sp...	[{"id": "", "caption": "Correlation matrix using Pearson’s correlation coefficient between parameters and National Early Warning Score 2 (NEWS2) on admission and outcomes. DBP, diastolic blood pressure; ICU, intensive care unit; SBP, systolic blood pressure; CVPU, new Confusion, Voice, Pain, Unresponsive; RR, Respirati...	[{"caption": "NEWS2 as a predictor of critical events compared with supplemented NEWS2", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Model</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Death<break />AUC (95% CI)<...
PMC10015673	Implementation of a digital early warning score (NEWS2) in a cardiac specialist and general hospital settings in the COVID-19 pandemic: a qualitative study	[ "Amitava Banerjee", "Louise Hicks", "Daniel Melley", "Riyaz Patel", "Timothy Bonicci", "Baneen Alhmoud" ]	To evaluate implementation of digital National Early Warning Score 2 (NEWS2) in a cardiac care setting and a general hospital setting in the COVID-19 pandemic. Thematic analysis of qualitative semistructured interviews using the non-adoption, abandonment, scale-up, spread, sustainability framework with purposefully sam...	10.1136/bmjoq-2022-001986	[ "implementation science", "clinical decision-making", "attitude of health personnel", "nurses", "qualitative research" ]	[{"citation_id": "R1", "related_text": ["Prediction tools in acute care settings can improve patient safety through enhanced efficiency of care and reduced pressure on health systems.1 Early warning scores (EWS) are a potential solution to decrease critical events, unnecessary deaths and debilitating resources.2–4 EWS ...	{"introduction": "Prediction tools in acute care settings can improve patient safety through enhanced efficiency of care and reduced pressure on health systems.1 Early warning scores (EWS) are a potential solution to decrease critical events, unnecessary deaths and debilitating resources.2–4 EWS have become part of the...	[{"id": "", "caption": "Themes and subthemes emerging from the non-adoption, abandonment, scale-up, spread, sustainability (NASSS) framework domains. Bubble colours relate subthemes to the main themes formed. EHR, electronic health record; EWS, early warning score; NEWS2, National Early Warning Score 2.", "related_text...	[{"caption": "Culture and system characteristics of interview participants", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Participant</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Hospital specialisation</td><td a...
PMC10015776	NEMoE: a nutrition aware regularized mixture of experts model to identify heterogeneous diet-microbiome-host health interactions	[ "Jean Y. H. Yang", "Samuel Muller", "Ryan L. Davis", "Carolyn M. Sue", "Andrew J. Holmes", "Michal Lubomski", "Xiangnan Xu" ]	Unrevealing the interplay between diet, the microbiome, and the health state could enable the design of personalized intervention strategies and improve the health and well-being of individuals. A common approach to this is to divide the study population into smaller cohorts based on dietary preferences in the hope of ...	10.1186/s40168-023-01475-4	[ "Mixture of experts", "Nutrition", "Microbiome", "Subcohort", "Latent class" ]	[{"citation_id": "CR1", "related_text": ["The human body is home to complex microbial communities, collectively known as the microbiome, which is mostly made up of prokaryotes (bacteria) and archaea [1]. Considerable evidence has emerged indicating that the microbiome is an important contributor to an individual’s heal...	{"introduction": "The human body is home to complex microbial communities, collectively known as the microbiome, which is mostly made up of prokaryotes (bacteria) and archaea [1]. Considerable evidence has emerged indicating that the microbiome is an important contributor to an individual’s health [2]. This has been il...	[{"id": "", "caption": "Results of NEMoE on gut microbiome-PD study. a Coefficients of experts network in NEMoE at different taxonomic levels. The two latent classes showed distinctly different microbiome patterns. b Identification of diet-specific microbial signatures of PD. The “Same direction” class showed consisten...	[{"caption": "Summary of Simulation settings", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Simulation Description</th><th>\n<italic>n</italic>\n</th><th>\n<italic>p</italic>\n<sup>c</sup>\n</th><th>\n<italic>q</italic>\n</th><th>\n<italic>η</italic>\n</th><th>\n<italic>c</italic>\n<sub><italic>e...
PMC10015804	Stakeholders’ Perspectives on the Feasibility of Adopting a Healthy Nail Salon Recognition Program in Philadelphia: A Qualitative Study	[ "Tran B Huynh", "Jessie K Pintor", "Chau Nguyen", "Duong T Nguyen" ]	The California Healthy Nail Salon Recognition Program is a statewide initiative to incentivize nail salons to adopt occupational health and safety best practices such as the use of safer nail products without certain harmful chemicals, ventilation systems upgrade, proper personal protective equipment use, and staff tra...	10.1093/annweh/wxac092	[ "policy intervention", "nail salon workers", "implementation science", "health disparities" ]	[{"citation_id": "CIT0001", "related_text": ["Since 2010, with the help of the California Healthy Nail Salon Collaborative, several local health departments in CA have implemented healthy nail salon recognition programs (HNSRP) to incentivize salons to adopt occupational safety and health best practices (California Hea...	{"introduction": "Low-wage, precariously employed, minority nail care workers are an underserved community in the US (Sharma et al., 2018) despite the documented harmful respiratory, neurological, and reproductive health effects from chronic exposure to low levels of chemicals from nail products and other work-related ...	[{"id": "", "caption": "Summary of themes in the context of the CIFR framework. Potential key facilitators are in blue ovals, barriers in orange rectangles, and themes that can be both a barrier and a facilitator in gray rectangles with rounded corners.", "related_text": "Figure 1 summarizes key facilitators (blue oval...	[{"caption": "Interview guide and CFIR constructs.", "content": "<table frame=\"hsides\" rules=\"groups\" width=\"100%\" border=\"1\"><colgroup span=\"1\"><col align=\"left\" span=\"1\" /><col align=\"left\" span=\"1\" /></colgroup><thead><tr><th align=\"center\" rowspan=\"1\" colspan=\"1\">Questions</th><th align=\"ce...
PMC10016238	Protocol for the Pathways Study: a realist evaluation of staff social ties and communication in the delivery of neonatal care in Kenya	[ "Geoff Wong", "Peris Muoga Musitia", "Mwanamvua Boga", "Sassy Molyneux", "Jacob McKnight", "Lisa Hinton", "Mike English", "Juliet Jepkosgei", "Claire Blacklock", "Conrad Wanyama" ]	The informal social ties that health workers form with their colleagues influence knowledge, skills and individual and group behaviours and norms in the workplace. However, improved understanding of these ‘software’ aspects of the workforce (eg, relationships, norms, power) have been neglected in health systems researc...	10.1136/bmjopen-2022-066150	[ "NEONATOLOGY", "Quality in health care", "Health policy" ]	[{"citation_id": "R1", "related_text": ["Despite significant reductions in mortality rates across other age groups among children under 5 in recent years, the neonatal mortality rate in Kenya has remained relatively unchanged.1 2 In response to this disparity, efforts are ongoing to improve the quality of neonatal care...	{"introduction": "Despite significant reductions in mortality rates across other age groups among children under 5 in recent years, the neonatal mortality rate in Kenya has remained relatively unchanged.1 2 In response to this disparity, efforts are ongoing to improve the quality of neonatal care, the majority of which...	[{"id": "", "caption": "Programme Theory Development in the Pathways Study. The figure shows the dynamic and iterative process of theory development and refinement in the Pathways Study, starting from the initial programme theory, to the development of middle-range programme theory and recommendations for practice, usi...	[{"caption": "Data collection procedures", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">Method</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\">When</td><td align=\"left\" valign=\"bottom\" rowspan=\"1\" colspan=\"1\...
PMC10016261	Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study	[ "Chinh Quoc Luong", "Andrew Li", "Jason Phua", "Anh Dat Nguyen", "Chi Van Nguyen", "Thao Thi Ngoc Pham", "Tam Van Bui", "Giang Thi Huong Bui", "Giang Thi Tra Pham", "Vuong Hung Le", "Tuan Dang Nguyen", "Phuoc Thien Duong", "Lien Thi Bao Nguyen", "Thuy Thi Phuong Le", "Hai Bui Hoang", "...	To compare the accuracy of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Scores in predicting mortality among intensive care unit (ICU) patients with sepsis in a low-income and middle-income country. A multicentre, cross-sectional study. A total of 15 a...	10.1136/bmjopen-2022-064870	[ "BACTERIOLOGY", "ACCIDENT & EMERGENCY MEDICINE", "INTENSIVE & CRITICAL CARE", "Adult intensive & critical care" ]	[{"citation_id": "R1", "related_text": ["Sepsis is a clinical syndrome which has physiological, biological and biochemical abnormalities caused by a dysregulated host response to infection and is a critical global health problem.1 2 Sepsis is the most common cause of in-hospital deaths, with most of the burden in low-i...	{"introduction": "Sepsis is a clinical syndrome which has physiological, biological and biochemical abnormalities caused by a dysregulated host response to infection and is a critical global health problem.1 2 Sepsis is the most common cause of in-hospital deaths, with most of the burden in low-income and middle-income...	[{"id": "", "caption": "Comparisons of the AUROCs: Comparing the overall diagnostic performance of the SOFA Score (AUROC: 0.713 (95% CI 0.643 to 0.783); cut-off value≥9.5; sensitivity: 53.6%; specificity: 80.1%; PAUROC<0.001) and the APACHE II Score (AUROC: 0.672 (95% CI 0.603 to 0.742); cut-off value≥18.5; sensitivity...	[{"caption": "Factors relating to intensive care unit mortality in patients with sepsis", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><td align=\"left\" valign=\"bottom\" rowspan=\"3\" colspan=\"1\">Factors</td><td align=\"left\" valign=\"bottom\" colspan=\"4\" rowspan=\"1\">Univariable logistic reg...
PMC10016347	Using Parametric g-Computation to Estimate the Effect of Long-Term Exposure to Air Pollution on Mortality Risk and Simulate the Benefits of Hypothetical Policies: The Canadian Community Health Survey Cohort (2005 to 2015)	[ "Tarik Benmarhnia", "Jay S. Kaufman", "Yi Li", "Megan Kirby-McGregor", "Michael Tjepkema", "Li Chen", "Randall V. Martin", "Richard T. Burnett", "Aaron van Donkelaar", "Hong Chen", "Chen Chen" ]	Numerous epidemiological studies have documented the adverse health impact of long-term exposure to fine particulate matter [particulate matter ≤2.5μm in aerodynamic diameter (PM2.5)] on mortality even at relatively low levels. However, methodological challenges remain to consider potential regulatory intervention’s co...	10.1289/EHP11095	[]	[{"citation_id": "c1", "related_text": ["Given that collective efforts in previous decades have successfully reduced the level of fine particulate matter [particulate matter ≤2.5μm in aerodynamic diameter (PM2.5)] globally, quantifying the effectiveness of policies that further reduce ambient PM2.5 is becoming particul...	{"introduction": "Given that collective efforts in previous decades have successfully reduced the level of fine particulate matter [particulate matter ≤2.5μm in aerodynamic diameter (PM2.5)] globally, quantifying the effectiveness of policies that further reduce ambient PM2.5 is becoming particularly important in suppo...	[{"id": "", "caption": "Differences in 11-y cumulative mortality risks comparing different intervention strategies to natural course for main analysis and sensitivity analyses. Numeric results are presented in Tables 3 and S4. Note: 65+, subset analysis restricted to cohort participants ≥65 years of age; Cat, including...	[{"caption": "Summaries of estimated 11-y cumulative mortality risk under different intervention strategies pooled across cycles and differences in estimated risk compared with natural course in relative and absolute scale, and corresponding average simulated PM2.5 and proportion of cohort participants with exposure ch...
PMC10017042	The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy	[ "Casper Rokx", "Tokameh Mahmoudi", "Annelies Verbon", "Birgit C. P. Koch", "Rob A. Gruters", "Peter D. Katsikis", "Thibault Mesplède", "David A. M. C. van de Vijver", "Jeroen J. A. van Kampen", "Robert-Jan Palstra", "David Burger", "Angela Colbers", "Els van Nood", "Mariana de Mendonça Mel...	Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). Twenty-eight PLWH on suppressive antiretroviral therapy were randomized (1:1:1:1 ratio) to receiv...	10.1126/sciadv.ade6675	[]	[{"citation_id": "R1", "related_text": ["Despite markedly improved treatment prospects brought about by combination antiretroviral therapy (cART), an infection with HIV-1 remains a chronic condition that, with few exceptions, necessitates lifelong cART. A pool of long-lived CD4+ T cells harbors latent, replication-comp...	{"introduction": "Despite markedly improved treatment prospects brought about by combination antiretroviral therapy (cART), an infection with HIV-1 remains a chronic condition that, with few exceptions, necessitates lifelong cART. A pool of long-lived CD4+ T cells harbors latent, replication-competent provirus integrat...	[{"id": "", "caption": "(A to D) Graphs represent measurements of inducible reservoir size in samples obtained from participants from pyrimethamine (A), VPA (B), control (C), and the combination treatment arm with pyrimethamine and VPA (D) at treatment initiation (day 0, t = 0 hours), 28 days after the end of treatment...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><col width=\"%\" span=\"1\" /><thead><tr><th align=\"left\" scope=\"col\" valign=\"top\" rowspan=\"1...
PMC10017756	Performance of microbiological tests for tuberculosis diagnostic according to the type of respiratory specimen: A 10-year retrospective study	[ "Onya Opota", "Gilbert Greub", "Katia Jaton", "Jesica Mazza-Stalder", "Valérie Chavez", "Christophe von-Garnier", "René Brouillet", "Rina Neziri", "Justin Denis-Lessard", "Marc-Olivier Boldi" ]	The microbial diagnosis of tuberculosis (TB) remains challenging and relies on multiple microbiological tests performed on different clinical specimens. Polymerase chain reactions (PCRs), introduced in the last decades has had a significant impact on the diagnosis of TB. However, questions remain about the use of PCRs ...	10.3389/fcimb.2023.1131241	[ "acid-fast bacilli (AFB)", "induced-sputum", "sputum", "bronchial aspirate", "bronchoalveolar lavage (BAL)", "mycobacterial culture", "PCR", "tuberculosis" ]	[{"citation_id": "B1", "related_text": ["Our results confirm a limited sensitivity of smear microscopy (0.523). The specificity (0.994) remains high, probably because of the extremely low prevalence (0.036) of positive microscopy. Our data suggest a higher sensitivity of microscopy on sputum over the three other sample...	{"introduction": "With over ten million new cases in 2020 and about 1,5 million deaths, tuberculosis represents a major public health concern (WHO, 2021a). Rapid and reliable diagnosis is important to reduce morbidity and mortality associated with tuberculosis and to control transmission. When tuberculosis is suspected...	[{"id": "", "caption": "Patient’s demographic. The figure shows the patient’s distribution of ages at first consultation by gender and disease status. A composite gold standard based on microbiological results and clinical data was used for disease status.", "related_text": "For all specimens, information regarding the...	[{"caption": "Sensitivity of culture to predict tuberculosis according to the type of specimen using a 72-hours pairing window within the same patient.", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th valign=\"top\" align=\"left\" rowspan=\"1\" colspan=\"1\" /><th valign=\"top\" align=\"center\" ro...
PMC10017967	Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival	[ "Alfredo Iacoangeli", "Ashley R. Jones", "Ammar Al-Chalabi", "Gerome Breen", "Richard J. B. Dobson", "Patrick Vourc’h", "Jonathan D. Glass", "John E. Landers", "Karen E. Morrison", "Pamela J. Shaw", "Christopher E. Shaw", "Nazli A. Başak", "Markus Weber", "Peter M. Andersen", "Mónica Pov...	Introduction: Caveolin-1 and Caveolin-2 (CAV1 and CAV2) are proteins associated with intercellular neurotrophic signalling. There is converging evidence that CAV1 and CAV2 (CAV1/2) genes have a role in amyotrophic lateral sclerosis (ALS). Disease-associated variants have been identified within CAV1/2 enhancers, which r...	10.3389/fncel.2023.1112405	[ "enhancer variant", "CAV1 and CAV2", "Cav", "caveolin", "survival analysis", "differential expression analysis (DEA)", "neurodegeneration", "ALS (Amyotrophic lateral sclerosis)" ]	[{"citation_id": "B2", "related_text": ["Individuals who have a first-degree relative with ALS are twice as likely than average to develop ALS (Al-Chalabi et al., 2010), and patients with a family history (familial ALS) make up approximately 5%–10% of cases (Zou et al., 2017). A pathogenic variant for familial patients...	{"introduction": "Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons. It is characterised by the progressive loss of motor function, leading to muscle weakness, difficulty breathing and swallowing, and paralysis. There is currently no treatment, with a mean ...	[{"id": "", "caption": "Survival Curves comparing survival of patients with vs without any CAV1/2 mutation. The left graph is based upon data from Analysis 1, inclusive of patients with C9orf72 repeat expansion. The right graph is from Analysis 2, with C9orf72 samples removed. Patients with CAV1/2 mutations have a long...	[{"caption": "The left side of the table describes the inclusion criteria and CAV+/CAV− sample size; the right size shows results from age of onset analyses using Cox proportional hazards and linear regression models; ***p < 0.001.", "content": "<table xmlns:ns0=\"http://www.w3.org/1999/xlink\" frame=\"hsides\" rules=\...
PMC10018178	Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment	[ "Steven E. Arnold", "Martin Stengelin", "George Sigal", "Christopher Campbell", "Pradeepthi Bathala", "Anahit Aghvanyan", "Bradley T. Hyman", "Matthew P. Frosch", "Derek H. Oakley", "Deborah Blacker", "Teresa Gomez-Isla", "Bradford C. Dickerson", "Keith A. Johnson", "Clemens R. Scherzer", ...	The last few years have seen major advances in blood biomarkers for Alzheimer's Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurodegenerative dementias. We evaluated a panel of four novel ultrasensitive electrochemiluminesc...	10.3389/fneur.2023.1069411	[ "total Tau (tTau)", "glial fibrillary acidic protein (GFAP)", "neurofilament light (NfL)", "pTau181", "mild cognitive impairment", "Alzheimer's disease", "plasma", "biomarker" ]	[{"citation_id": "B1", "related_text": ["Individuals with mild cognitive impairment (MCI) provide a challenge to the clinician due to the difficulty of predicting if an individual will experience further cognitive decline and the rate of decline. We tested the hypothesis that the presence of pathological changes of Alz...	{"introduction": "Individuals with mild cognitive impairment (MCI) provide a challenge to the clinician due to the difficulty of predicting if an individual will experience further cognitive decline and the rate of decline. We tested the hypothesis that the presence of pathological changes of Alzheimer disease (AD), as...	[{"id": "", "caption": "Correlation between CDR Sum of Boxes or MMSE and plasma levels of (A, E) pTau181, (B, F) tTau, (C, G) NfL, and (D, H) GFAP using Spearman rank-order correlation. Spearman's rho with 95% confidence interval and p-values are show on top of each panel.", "related_text": "Finally, we assessed if pla...	[{"caption": "Clinical performance of the four biomarker assays in Sample B (“High contrast” diagnostic sample).", "content": "<table frame=\"box\" rules=\"all\"><thead><tr style=\"background-color:#919497\"><th rowspan=\"1\" colspan=\"1\" /><th valign=\"top\" align=\"left\" colspan=\"2\" rowspan=\"1\"><bold>CN (</bold...
PMC10019140	Effects of CFTR modulators on serum biomarkers of liver fibrosis in children with cystic fibrosis	[ "Zachary M. Sellers", "Russell Wise", "Yonathan Fuchs", "Steven Levitte" ]	The cystic fibrosis (CF) transmembrane conductance regulator corrector/potentiator combinations lumacaftor/ivacaftor and elexacaftor/tezacaftor/ivacaftor improve sweat chloride, pulmonary function, and nutrition. Yet it is unclear whether they may also impact the progression of liver fibrosis, which is a substantial so...	10.1097/HC9.0000000000000010	[]	[{"citation_id": "R1", "related_text": ["Lumacaftor/ivacaftor and elexacaftor/tezacaftor/ivacaftor are approved in the United States for the treatment of cystic fibrosis (CF) in those with homozygous or compound heterozygous F508del cystic fibrosis transmembrane conductance regulator (CFTR) mutations, respectively. Cli...	{"introduction": "Lumacaftor/ivacaftor and elexacaftor/tezacaftor/ivacaftor are approved in the United States for the treatment of cystic fibrosis (CF) in those with homozygous or compound heterozygous F508del cystic fibrosis transmembrane conductance regulator (CFTR) mutations, respectively. Clinical trials showed tha...	[{"id": "", "caption": "", "related_text": "", "image_candidates": []}, {"id": "", "caption": "", "related_text": "", "image_candidates": []}, {"id": "", "caption": "Changes in liver function tests and liver fibrosis indices during lumacaftor/ivacaftor (LUMA/IVA) followed by elexacaftor/tezacaftor/ivacaftor (ELEX/TEZA/...	[{"caption": "Characteristics of cohorts", "content": "<table frame=\"hsides\" rules=\"groups\"><col align=\"left\" width=\"1\" span=\"1\" /><col align=\"left\" width=\"1\" span=\"1\" /><col align=\"left\" width=\"1\" span=\"1\" /><col align=\"left\" width=\"1\" span=\"1\" /><col align=\"left\" width=\"1*\" span=\"...
PMC10020069	The association between experience of COVID-19-related discrimination and psychological distress among healthcare workers for six national medical research centers in Japan	[ "Tetsuya Mizoue", "Kengo Miyo", "Maki Konishi", "Manami Inoue", "Shiori Tanaka", "Jun Umezawa", "Soshiro Ogata", "Kunihiro Nishimura", "Takeshi Nakagawa", "Masayo Kojima", "Takeshi Miyama", "Kazuyoshi Takeda", "Yohei Sasaki", "Koushi Yamaguchi", "Kazue Ishizuka", "Takanori Funaki", "...	Discrimination is an important determinant of negative mental health outcomes. This study determined the association between the experience of COVID-19-related discrimination and psychological distress among healthcare workers (HCWs) in Japan. This cross-sectional study conducted a health survey among 5703 HCWs of six ...	10.1007/s00127-023-02460-w	[ "Mental health", "Psychological distress", "Discrimination", "Healthcare workers", "COVID-19" ]	[{"citation_id": "CR1", "related_text": ["Since the emergence of ongoing coronavirus disease 2019 (COVID-19) pandemic, it has become a global health threat. Healthcare workers (HCWs), particularly those involved in COVID-19-related patient care were at a heightened risk of infection [1, 2]. For example, a meta-analysis...	{"introduction": "Since the emergence of ongoing coronavirus disease 2019 (COVID-19) pandemic, it has become a global health threat. Healthcare workers (HCWs), particularly those involved in COVID-19-related patient care were at a heightened risk of infection [1, 2]. For example, a meta-analysis, including 28 studies f...	[{"id": "", "caption": "Flow diagram of study participants", "related_text": "Of the 11,438 staff members invited for the survey, 5919 participated (51.7% participation rate) (Fig. 1). We requested all the eligible participants to complete a questionnaire survey. After excluding participants without questionnaire data ...	[{"caption": "Association between discrimination and severe psychological distress among the total and subgroups of study population", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\" /><th align=\"left\">Psychological distress, n (%)</th><th align=\"left\">AOR (95% CI) associated with...
PMC10020138	Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data	[ "Margaret N Kosek", "Benjamin F Zaitchik", "Eric Houpt", "Vonethalom Thongpaseuth", "Anna N Chard", "Matthew Freeman", "Mario Melgar", "James Gaensbauer", "Sabrina J Moyo", "Nina Langeland", "Warawan Wongboot", "Kazuhisa Okada", "Andrew J Prendergast", "Robert Ntozini", "Jean Humphrey", ...	Diarrhoeal disease is a leading cause of childhood illness and death globally, and Shigella is a major aetiological contributor for which a vaccine might soon be available. The primary objective of this study was to model the spatiotemporal variation in paediatric Shigella infection and map its predicted prevalence acr...	10.1016/S2214-109X(22)00549-6	[]	[{"citation_id": "bib1", "related_text": ["Shigella, a genus of gram-negative bacteria, infects over 267 million people annually in low-income and middle-income countries (LMICs) and is responsible for over 212 000 diarrhoeal disease deaths per year in all ages.1 It is most commonly recognised via its manifestation as ...	{"introduction": "Shigella, a genus of gram-negative bacteria, infects over 267 million people annually in low-income and middle-income countries (LMICs) and is responsible for over 212 000 diarrhoeal disease deaths per year in all ages.1 It is most commonly recognised via its manifestation as bacillary dysentery, with...	[{"id": "", "caption": "Seasonality metrics for Shigella positivity in asymptomatic children aged 12–23 months predicted by the model:", "related_text": "The supplementary animation (video) shows the temporal variation in the predictions for each day of the year 2018, while figure 5 shows the geographical distribution ...	[{"caption": "Number (and percent) of stool samples with available Shigella spp positivity status used in this analysis by child's age and diarrhoea symptom status", "content": "<table frame=\"hsides\" rules=\"groups\"><thead><tr><th /><th align=\"left\"><bold>Asymptomatic</bold></th><th colspan=\"2\" align=\"left\"><b...
PMC10020237	The mental wellbeing of prison staff in England during the COVID-19 pandemic: A cross-sectional study	[ "Emma Plugge", "Julie Parkes", "Nuala McGrath", "Kerry Gutridge", "Maciej Czachorowski", "Luke Johnson" ]	COVID-19 is likely to have had an impact on the mental wellbeing of prison staff because of the high risk for infectious disease outbreaks in prisons and the pre-existing high burden of mental health issues among staff. A cross-sectional study of staff within 26 prisons in England was carried out between 20th July 2020...	10.3389/fpubh.2023.1049497	[ "health inequalities", "occupational health", "mental health", "wellbeing", "prison", "COVID-19" ]	[{"citation_id": "B1", "related_text": ["Worldwide, there are over 10 million people imprisoned (1). Early in the COVID-19 pandemic, prisons were classified as high-risk environments for outbreaks because of overcrowded conditions, frequent staff changes, and the regular movement of people in to, out of, and between pr...	{"introduction": "Worldwide, there are over 10 million people imprisoned (1). Early in the COVID-19 pandemic, prisons were classified as high-risk environments for outbreaks because of overcrowded conditions, frequent staff changes, and the regular movement of people in to, out of, and between prisons (2). Additionally...	[{"id": "", "caption": "Histogram of SWEMWBS variable.", "related_text": "Descriptive statistics and mean SWEMWBS score in each category are presented in Table 2. The mean SWEMWBS score was 23.84 (range 7–35; SD 4.84). The distribution of scores is shown in Figure 2. The distribution was judged as approximately normal ...	[{"caption": "Primary model: Unadjusted and adjusted linear regression models for predicting SWEMWBS score.", "content": "<table frame=\"box\" rules=\"all\"><thead><tr style=\"background-color:#919498;color:#ffffff\"><th rowspan=\"1\" colspan=\"1\" /><th valign=\"top\" align=\"center\" style=\"border-bottom: thin solid...
PMC10020634	Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis	[ "Eduardo Villamor", "Moreyba Borges-Lujan", "Gema E Gonzalez-Luis" ]	Endotypes leading to very and extremely preterm birth are clustered into two groups: infection/inflammation and dysfunctional placentation. We conducted a systematic review of observational studies exploring the association between these two endotypes and the pharmacological closure of patent ductus arteriosus (PDA) in...	10.3389/fped.2023.1078506	[ "ibuprofen", "indomethacin", "endotypes", "small for gestational age", "preeclampsia", "hypertensive disorders of pregnancy", "chorioamnionitis", "ductus arteriosus" ]	[{"citation_id": "B1", "related_text": ["The ductus arteriosus (DA) is a fetal vessel connecting the pulmonary artery to the descending aorta, which is of major functional importance for the integrity of the fetal circulation (1–6). Morphological and functional maturation of the DA during fetal life prepares the vessel...	{"introduction": "The ductus arteriosus (DA) is a fetal vessel connecting the pulmonary artery to the descending aorta, which is of major functional importance for the integrity of the fetal circulation (1–6). Morphological and functional maturation of the DA during fetal life prepares the vessel for functional and the...	[{"id": "", "caption": "Meta-analysis on the association between being small for gestational age (SGA) and pharmacological closure of patent ductus arteriosus.", "related_text": "In addition to the subgroup analysis based on the definition of the different exposures (Figures 1–3), we conducted a second analysis based o...	[{"caption": "Meta-regression analysis of continuous covariates.", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" span=\"1\" /><col align=\"left\" span=\"1\" /><col align=\"center\" span=\"1\" /><col align=\"center\" span=\"1\" /><col align=\"center\" span=\"1\" /><col ali...
PMC10021139	Implementation of an interactive mobile application to pilot a rapid assay to detect HIV drug resistance mutations in Kenya	[ "Ingrid A. Beck", "Eric Klavins", "Barry R. Lutz", "Lisa M. Frenkel", "Michael H. Chung", "Bhavna Chohan", "Samar R. Sakr", "Yaoyu Yang", "James J. Lai", "Ruth Kanthula", "Parker Ruth", "Daisy Ko", "Nikki Higa", "Nuttada Panpradist", "Justin D. Vrana" ]	Usability is an overlooked aspect of implementing lab-based assays, particularly novel assays in low-resource-settings. Esoteric instructions can lead to irreproducible test results and patient harm. To address these issues, we developed a software application based on “Aquarium”, a laboratory-operating system run on a...	10.1371/journal.pgph.0000185	[]	[{"citation_id": "pgph.0000185.ref001", "related_text": ["In resource-rich communities, automation drastically improves the daily operation of clinical laboratories [1–3]. Patient samples can be quickly shipped to centralized laboratories for batch-processing and testing using highly efficient workflows that generate h...	{"introduction": "In resource-rich communities, automation drastically improves the daily operation of clinical laboratories [1–3]. Patient samples can be quickly shipped to centralized laboratories for batch-processing and testing using highly efficient workflows that generate high-quality results while reducing costs...	[{"id": "", "caption": "(A) Examples of scanned images of test strips for Samples 1 and 2 and test accuracy across each codon based on visual calls made by each participant and post-processing by image analysis software. Sample1 and Sample 2 have different mutation profiles. (B) Mutant (MUT) signal intensity of each la...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" colspan=\"1\">Variable</th><th align=\"center\" rowspan=\"1\" colspan=\"...
PMC10021168	Are midwives ready to provide quality evidence-based care after pre-service training? Curricula assessment in four countries—Benin, Malawi, Tanzania, and Uganda	[ "Claudia Hanson", "Antoinette Sognonvi", "Max Petzold", "Gorrette Nalwadda", "Beatrice Mwilike", "Bianca Kandeya", "Hashim Hounkpatin", "Gisele Houngbo", "Mechthild M. Gross", "Effie Chipeta", "Elizabeth Ayebare", "Joanne Welsh", "Ann-Beth Moller" ]	This research sought to map midwifery pre-service training curricula as part of the Action Leveraging Evidence to Reduce perinatal morTality and morbidity in sub-Saharan Africa (ALERT) project conducted in Benin, Malawi, Tanzania, and Uganda. We conducted the review in two phases. In the first phase, online interviews ...	10.1371/journal.pgph.0000605	[]	[{"citation_id": "pgph.0000605.ref001", "related_text": ["Maternal and newborn health care is key to sustainable development at local and global levels. Despite huge progress in improving health outcomes for women and newborns, many low-and middle-income countries (LMICs), particularly in sub-Saharan Africa, continue t...	{"introduction": "Maternal and newborn health care is key to sustainable development at local and global levels. Despite huge progress in improving health outcomes for women and newborns, many low-and middle-income countries (LMICs), particularly in sub-Saharan Africa, continue to struggle with high rates of maternal a...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021174	Field evaluation of specificity and sensitivity of a standard SARS-CoV-2 antigen rapid diagnostic test: A prospective study at a teaching hospital in Northern Ghana	[ "Albrecht Jahn", "Olaf Müller", "Claudia M. Denkinger", "Lisa Hennig", "Anna-Katharina Heuschen", "Kareem Mumuni", "Benjamin Demah Nuertey", "Abass Abdul-Karim", "Faith Agbozo", "Abdulai Abubakari", "Alhassan Abdul-Mumin" ]	The testing capacity for SARS-CoV-2 in Africa is rather limited. Antigen detection rapid diagnostic tests (Ag-RDTs) are a cheap and rapid alternative to reverse transcriptase-polymerase chain reaction (RT-PCR) tests, but there is little data about their performance under real life conditions in tropical countries. The ...	10.1371/journal.pgph.0000040	[]	[{"citation_id": "pgph.0000040.ref001", "related_text": ["The emergence of COVID-19 in China by the end of 2019 has led to the largest pandemic in recent human history [1,2]. It had initially been predicted, that Africa would become the worst affected global region, due to its weak health systems, prevailing poverty, a...	{"introduction": "The emergence of COVID-19 in China by the end of 2019 has led to the largest pandemic in recent human history [1,2]. It had initially been predicted, that Africa would become the worst affected global region, due to its weak health systems, prevailing poverty, and the existing high burden of infectiou...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021179	qPCR in a suitcase for rapid Plasmodium falciparum and Plasmodium vivax surveillance in Ethiopia	[ "Cristian Koepfli", "Werissaw Haileselassie", "Delenasaw Yewhalaw", "Tiffany Huwe", "Sarah Cate Baker", "Lise Carlier" ]	Many Plasmodium spp. infections, both in clinical and asymptomatic patients, are below the limit of detection of light microscopy or rapid diagnostic test (RDT). Molecular diagnosis by qPCR can be valuable for surveillance, but is often hampered by absence of laboratory capacity in endemic countries. To overcome this l...	10.1371/journal.pgph.0000454	[]	[{"citation_id": "pgph.0000454.ref001", "related_text": ["Malaria remains a major public health threat in many countries in the tropics and subtropics. After a decade of progress with a pronounced reduction of the number of clinical cases and deaths, progress has stalled in recent years. In 2020, over 240 million cases...	{"introduction": "Malaria remains a major public health threat in many countries in the tropics and subtropics. After a decade of progress with a pronounced reduction of the number of clinical cases and deaths, progress has stalled in recent years. In 2020, over 240 million cases and 600,000 deaths were recorded [1]. A...	[{"id": "", "caption": "", "related_text": "P. vivax prevalence among asymptomatic individuals was 3.8% (25/653). None of them was positive by microscopy or RDT (Fig 2). The age of positive individuals ranged from 1.5 to 60 years. No significant difference in prevalence rate among age groups was observed (Table 2). Pre...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021185	The role of sociodemographic and psychosocial variables in early childhood development: A secondary data analysis of the 2014 and 2019 Multiple Indicator Cluster Surveys in the Dominican Republic	[ "Arachu Castro", "Laura V. Sánchez-Vincitore" ]	The association between sociodemographic factors—poverty, lack of maternal schooling, being male at birth—, childhood developmental delay, and poor educational outcomes has been established in the Dominican Republic (DR). However, family moderating factors present or introduced to buffer sociodemographic factors effect...	10.1371/journal.pgph.0000465	[]	[{"citation_id": "pgph.0000465.ref001", "related_text": ["Early childhood development (ECD) is a multisectoral concern that involves global health, social assistance, education, and other sectors, particularly in contexts of poverty [1–4]. Approximately 249 million children in lower- and middle-income countries might n...	{"introduction": "Early childhood development (ECD) is a multisectoral concern that involves global health, social assistance, education, and other sectors, particularly in contexts of poverty [1–4]. Approximately 249 million children in lower- and middle-income countries might not develop fully due to stunting and liv...	[{"id": "", "caption": "SD1 = Child’s age in months; SD2 = Child’s sex (male); SD3 = Family socioeconomic position; SD4 = Mother’s level of education; PS1 = Stimulating activities at home; PS2a = Stimulating homemade toys and objects; PS2b = Stimulating store-bought toys; PS3 = Amount of books at home; PS4 = Attendance...	[{"caption": "MICS Dominican Republic 2014 and 2019.", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" ...
PMC10021193	The World Health Organization’s Disease Outbreak News: A retrospective database	[ "Rebecca Katz", "Alexandra L. Phelan", "Munir Pavez", "Max A. Palys", "Yasser Omar Abdellatif", "Jessica Lin", "Ellie Graeden", "Margaret Dunne", "Matthew R. Boyce", "Colin J. Carlson" ]	The World Health Organization (WHO) notifies the global community about disease outbreaks through the Disease Outbreak News (DON). These online reports tell important stories about both outbreaks themselves and the high-level decision making that governs information sharing during public health emergencies. However, th...	10.1371/journal.pgph.0001083	[]	[{"citation_id": "pgph.0001083.ref001", "related_text": ["The Disease Outbreak News (DON) is a public, online reporting system that serves as the only official outbreak record maintained by the World Health Organization (WHO). This system has been used since 1996, and shares event-based information provided by countrie...	{"introduction": "The first few days are often the most important to prevent outbreaks from becoming epidemics and pandemics; by warning the world early, countries can access resource stockpiles, funding mechanisms, and decision support tools; coordinate epidemic response and surveillance across borders; and prepare th...	[{"id": "", "caption": "Base map generated by R package ‘rnaturalearth’ using Natural Earth data compatible with CC BY 4.0 license.", "related_text": "As a final illustration of how these data could be used for more quantitative research, we conducted a simple analysis to explore which countries report more similar kin...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><tbody><tr><td align=\"left\" rowspan=\"1\" colspan=\"1\"><italic toggle=\"yes\">…WHO has good reason to believe that</italic>, <italic toggle=\"yes\">should SARS resu...
PMC10021204	Demographic and professional risk factors of SARS-CoV-2 infections among physicians in low- and middle-income settings: Findings from a representative survey in two Brazilian states	[ "Mário Scheffer", "Bruno Luciano Carneiro Alves De Oliveira", "Alex Cassenote", "Giuliano Russo" ]	Health workers (HWs) are a key resource for health systems worldwide, and have been affected heavily by the COVID-19 pandemic. Evidence is consolidating on incidence and drivers of infections, predominantly in high-income settings. It is however unclear what the risk factors may be for specific health professions, part...	10.1371/journal.pgph.0000656	[]	[{"citation_id": "pgph.0000656.ref001", "related_text": ["Health workers (HWs) are a crucial healthcare resource, as they are one of the key health system’s pillars, they deliver healthcare services, operate the health sector’s building blocks [1], and in most health systems, represent the largest single item of expend...	{"introduction": "Health workers (HWs) are a crucial healthcare resource, as they are one of the key health system’s pillars, they deliver healthcare services, operate the health sector’s building blocks [1], and in most health systems, represent the largest single item of expenditure [2, 3]. Their role and importance ...	[{"id": "", "caption": "", "related_text": "35.8% of all the physicians declared having been infected with SARS-CoV-2 in the previous year. Almost half (49.2%) [CI 45.0–53.4] of Maranhão physicians were infected, with the majority of them having suffered only mild or no symptoms (42.3%) (Fig 2). Conversely, in São Paul...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021220	Fairness and efficiency considerations in COVID-19 vaccine allocation strategies: A case study comparing front-line workers and 65–74 year olds in the United States	[ "Marc Lipsitch", "Mary T. Bassett", "Justin M. Feldman", "Eva Rumpler" ]	The COVID-19 epidemic in the United States has been characterized by two stark disparities. COVID-19 burden has been unequally distributed among racial and ethnic groups and at the same time the mortality rates have been sharply higher among older age groups. These disparities have led some to suggest that inequalities...	10.1371/journal.pgph.0001378	[]	[{"citation_id": "pgph.0001378.ref001", "related_text": ["Two stark disparities define the mortality impact of the COVID-19 epidemic in the United States. The risk of death given infection (infection fatality rate) rises sharply with age. By one estimate, this increase is exponential, about 10-fold for each 19-year inc...	{"introduction": "Two stark disparities define the mortality impact of the COVID-19 epidemic in the United States. The risk of death given infection (infection fatality rate) rises sharply with age. By one estimate, this increase is exponential, about 10-fold for each 19-year increase in age [1]. Another estimate fits ...	[{"id": "", "caption": "States are grouped by HHS Region. Stars indicate the race/ethnicity/state for which the lower bound of the 95% interval did not include 1.", "related_text": "The calculations in Table 4 are repeated for each state and the District of Columbia for which the number of deaths reported in each racia...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021234	COVID-19 vaccine equity and the right to health for displaced Venezuelans in Latin America	[ "Amaya Perez-Brumer", "Alfonso Silva-Santisteban", "Daniel Grace", "Lisa Forman", "Ellithia Adams", "Karla Solari", "Zafiro Andrade-Romo", "David C. Hill" ]	Given the magnitude of Venezuelan displacement in Latin America, there is a need to assess how migrants were, and will continue to be, addressed in COVID-19 vaccination policies. To explore migration status as a dimension of vaccine equity in Latin America and in relation to international human rights, we assessed nati...	10.1371/journal.pgph.0001275	[]	[{"citation_id": "pgph.0001275.ref001", "related_text": ["In January 2021, Dr. Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO), described the hoarding of COVID-19 vaccines by wealthy nations as a “catastrophic moral failure” that would “only prolong the pandemic, the restrictions nee...	{"introduction": "In January 2021, Dr. Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO), described the hoarding of COVID-19 vaccines by wealthy nations as a “catastrophic moral failure” that would “only prolong the pandemic, the restrictions needed to contain it, and human and economi...	[{"id": "", "caption": "Inner circle: Summary of select principles in the WHO/SAGE framework. Outer circle: Integrating human rights with WHO/SAGE to promote equitable access to COVID-19 vaccines for migrants.", "related_text": "Fig 1 builds on a modified WHO/SAGE Framework to present how COVID-19 vaccine allocation an...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021248	Estimating waiting times, patient flow, and waiting room occupancy density as part of tuberculosis infection prevention and control research in South African primary health care clinics	[ "Alison D. Grant", "Tom A. Yates", "Anna Vassall", "Hayley MacGregor", "Karina Kielmann", "Idriss I. Kallon", "Indira Govender", "Kathy Baisley", "Nicky McCreesh", "Aaron S. Karat" ]	Transmission of respiratory pathogens, such as Mycobacterium tuberculosis and severe acute respiratory syndrome coronavirus 2, is more likely during close, prolonged contact and when sharing a poorly ventilated space. Reducing overcrowding of health facilities is a recognised infection prevention and control (IPC) stra...	10.1371/journal.pgph.0000684	[]	[{"citation_id": "pgph.0000684.ref001", "related_text": ["Transmission of respiratory infections is a persistent problem in health care facilities: proportions of attendees who are infectious and susceptible are likely to be higher than in other settings [1–3]. As well as creating risk for individuals attending for car...	{"introduction": "Transmission of respiratory infections is a persistent problem in health care facilities: proportions of attendees who are infectious and susceptible are likely to be higher than in other settings [1–3]. As well as creating risk for individuals attending for care, nosocomial transmission can ‘institut...	[{"id": "", "caption": "*Data available only from 0830 for clinic KZN6. Height of each row proportional to the area of the space. Each clinic was visited on a different day. See Table H in S1 Text for occupancy density relative to room volume (persons/m3). Total numbers (line graph) indicative only of numbers of people...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021274	Suicide and self-harm in low- and middle- income countries during the COVID-19 pandemic: A systematic review	[ "David Gunnell", "Roger T. Webb", "Lena Schmidt", "Luke A. McGuinness", "Catherine Macleod-Hall", "Rakhi Dandona", "Jason Bantjes", "Julian P. T. Higgins", "Dana Dekel", "Emily Eyles", "Prianka Padmanathan", "Ann John", "Duleeka Knipe" ]	There is widespread concern over the potential impact of the COVID-19 pandemic on suicide and self-harm globally, particularly in low- and middle-income countries (LMIC) where the burden of these behaviours is greatest. We synthesised the evidence from the published literature on the impact of the pandemic on suicide a...	10.1371/journal.pgph.0000282	[]	[{"citation_id": "pgph.0000282.ref001", "related_text": ["There is major concern over the impact of the COVID-19 pandemic and associated public health measures on mental health, in particular a potential rise in suicide and self-harm. Analysis of data from 21 higher income countries indicated that there was no evidence...	{"introduction": "There is major concern over the impact of the COVID-19 pandemic and associated public health measures on mental health, in particular a potential rise in suicide and self-harm. Analysis of data from 21 higher income countries indicated that there was no evidence of an increase in suicide death rates d...	[{"id": "", "caption": "* An estimate of below 1 is indicative of a reduction in suicide or self harm. rRR–reported rate ratio; cRR–calculate rate ratio; OR–Odds ratio.", "related_text": "There was a single study from Sri Lanka that reported a 32% reduction in hospital presentations for self-poisoning during the pandem...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021282	Model-informed target product profiles of long-acting-injectables for use as seasonal malaria prevention	[ "Melissa A. Penny", "Jörg J. Möhrle", "Monica Golumbeanu", "Theresa Reiker", "Lydia Burgert" ]	Seasonal malaria chemoprevention (SMC) has proven highly efficacious in reducing malaria incidence. However, the continued success of SMC is threatened by the spread of resistance against one of its main preventive ingredients, Sulfadoxine-Pyrimethamine (SP), operational challenges in delivery, and incomplete adherence...	10.1371/journal.pgph.0000211	[]	[{"citation_id": "pgph.0000211.ref001", "related_text": ["Children carry the majority of the global malaria burden, with an estimated 67% of all malaria-related deaths (272 000 in 2019) occurring in those under 5 years of age [1]. In addition to effective and timely treatment, prevention through vector control or drug-...	{"introduction": "Children carry the majority of the global malaria burden, with an estimated 67% of all malaria-related deaths (272 000 in 2019) occurring in those under 5 years of age [1]. In addition to effective and timely treatment, prevention through vector control or drug-based prophylaxis has proven to be an ef...	[{"id": "", "caption": "(a) Heatmap of the estimated minimal coverage (colour) of sigmoidal LAIs at which non-inferiority to SMC-SP+AQ (assuming a fixed SMC coverage of 60%) is achieved for different combinations of sigmoidal LAI efficacy and half-life. The results are displayed for intervention scenarios with an under...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021293	Systematic review of food insecurity and violence against women and girls: Mixed methods findings from low- and middle-income settings	[ "Heidi Stöckl", "Celine Mazars", "Rebecca Fielding-Miller", "Isabelle Pearson", "Lele Aletta van Eck", "Sabrina Page", "Abigail M. Hatcher" ]	Violence against women and girls (VAWG) is a global human rights and public health concern. Food insecurity is a sign of severe poverty, and likely to heighten women’s vulnerability to VAWG and men’s perpetration of it. However, the extent of the association and the multiple pathways between food insecurity and VAWG ar...	10.1371/journal.pgph.0000479	[]	[{"citation_id": "pgph.0000479.ref001", "related_text": ["The World Health Organization estimates that globally, one in four women experience violence against women (VAWG) in their lifetime [1]. In sub-Saharan Africa, 44% of women experience VAWG from an intimate partner and one in six experience non-partner violence [...	{"introduction": "The World Health Organization estimates that globally, one in four women experience violence against women (VAWG) in their lifetime [1]. In sub-Saharan Africa, 44% of women experience VAWG from an intimate partner and one in six experience non-partner violence [2]. VAWG forms a persistent health crisi...	[{"id": "", "caption": "", "related_text": "The analysis of qualitative and mixed-methods findings suggests that the relationship between food insecurity and VAWG is underpinned by entrenched poverty and gender-inequitable norms. The following describes how the pathways of economic deprivation, alcohol use, and underly...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021303	Estimates of pandemic excess mortality in India based on civil registration data	[ "Aashish Gupta", "Murad Banaji" ]	The population health impacts of the COVID-19 pandemic are less well understood in low and middle-income countries, where mortality surveillance before the pandemic was patchy. Interpreting the limited all-cause mortality data available in India is challenging. We use existing data on all-cause mortality from civil reg...	10.1371/journal.pgph.0000803	[]	[{"citation_id": "pgph.0000803.ref001", "related_text": ["The COVID-19 pandemic has had large impacts on population health across the world. These impacts are less well understood in low- and middle-income countries [1–4], where routine mortality surveillance before the pandemic was patchy [5–7]. Daily case counts and ...	{"introduction": "The COVID-19 pandemic has had large impacts on population health across the world. These impacts are less well understood in low- and middle-income countries [1–4], where routine mortality surveillance before the pandemic was patchy [5–7]. Daily case counts and confirmed COVID-19 deaths have been wide...	[{"id": "", "caption": "Note: The excess deaths are estimated from data in STAR12 according to methods described in the text and elaborated further in Appendix 2. Data on official COVID-19 deaths is from covid19india.org (COVID19India 2021).", "related_text": "Qualitatively, national estimates of monthly excess deaths ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021332	Assessing the effectiveness of malaria interventions at the regional level in Ghana using a mathematical modelling application	[ "Sheetal P. Silal", "Timothy Awine" ]	Supporting malaria control with interfaced applications of mathematical models that enables investigating effectiveness of various interventions as well as their cost implications could be useful. Through their usage for planning, these applications may improve the prospects of attaining various set targets such as tho...	10.1371/journal.pgph.0000474	[]	[{"citation_id": "pgph.0000474.ref001", "related_text": ["In Ghana, the national strategic policy for malaria control (NSP) outlines a number of strategies to be deployed within the 2014–2020 period with the goal of achieving a 75.0% reduction in malaria morbidity and mortality. Among the objectives are the deployment ...	{"introduction": "Countries with high malaria burden have over the years fashioned out strategies with the goal to eliminate the disease. However, most of these countries will need to establish control of malaria first before contemplating the achievement of elimination within the shortest time frame with limited resou...	[{"id": "", "caption": "Predictions for malaria incidence for various intervention packages, singly (a1-c1) for Community Health Worker (CHW), Health System Strengthening (HSS), Indoor Residual Spraying (IRS), and Insecticide Treated bednets (ITN) and in combination (a2-c2) for CHW/CHPS + ITN, HSS + ITN and ITN + IRS f...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" colspan=\"1\">Zone</th><th align=\"left\" rowspan=\"1\" colspan=\"1\">Co...
PMC10021336	Modelling COVID-19 vaccine breakthrough infections in highly vaccinated Israel—The effects of waning immunity and third vaccination dose	[ "Daihai He", "Lewi Stone", "Uri Obolski", "Anyin Feng" ]	In August 2021, a major wave of the SARS-CoV-2 Delta variant erupted in the highly vaccinated population of Israel. The transmission advantage of the Delta variant enabled it to replace the Alpha variant in approximately two months. The outbreak led to an unexpectedly large proportion of breakthrough infections (BTI)–a...	10.1371/journal.pgph.0001211	[]	[{"citation_id": "pgph.0001211.ref001", "related_text": ["The COVID-19 pandemic caused tremendous impact globally, but would certainly have led to far more damage if effective vaccines against SARS-CoV-2 had not been rapidly developed and deployed. In addition, the emergence of new SARS-CoV-2 variants having higher tra...	{"introduction": "The COVID-19 pandemic caused tremendous impact globally, but would certainly have led to far more damage if effective vaccines against SARS-CoV-2 had not been rapidly developed and deployed. In addition, the emergence of new SARS-CoV-2 variants having higher transmissibility and potential for immune e...	[{"id": "", "caption": "(a) Breakthrough infection ratio among severe cases (BTI_Ratioi_severe) over time for all ages, age 60+ and age <60. (b) Daily reported severe cases for three types (unvaccinated, partly vaccinated, fully vaccinated) for all ages over time. (c) three types of daily severe cases for <60 years old...	[]
PMC10021342	Assessing the knowledge and practices of primary healthcare workers on malaria diagnosis and related challenges in view of COVID-19 outbreak in a Nigerian Southwestern metropolis	[ "Taiwo Obembe", "Olabisi Kalejaye", "Oladipo Afolayan", "Deborah Babatunde", "Esther Oluwayemisi Ayandipo" ]	The clinical features of COVID-19 and malaria are interrelated. Due to the similarity of symptoms between the two disease states, patients can be incorrectly diagnosed with the other ailment in areas with limited health resources. There is a dearth of knowledge of co-infection between COVID-19 and malaria from healthca...	10.1371/journal.pgph.0000625	[]	[{"citation_id": "pgph.0000625.ref001", "related_text": ["Malaria is a leading cause of death all over the world, and the most common reason for hospital admissions in many African countries [1]. Death rates are known to reduce when diagnosed and treated promptly [2]. Differentiating malaria from other tropical infecti...	{"introduction": "Malaria is a leading cause of death all over the world, and the most common reason for hospital admissions in many African countries [1]. Death rates are known to reduce when diagnosed and treated promptly [2]. Differentiating malaria from other tropical infections based on patients’ signs and symptom...	[{"id": "", "caption": "", "related_text": "Fig 3 revealed the challenges commonly faced by the health workers with malaria diagnosis. Lack of adequate training on malaria diagnosis (27.8%) and unavailability of mRDT (18.4%) were the leading challenges with malaria diagnosis identified by healthcare workers.", "image_c...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021381	Pregnant women’s knowledge of obstetrical danger signs: A cross-sectional survey in Kigali, Rwanda	[ "Diomede Ntasumbumuyange", "Pamela Meharry", "Patricia J. Moreland", "Janviere Bayizere", "Pacifique Ufitinema", "Neophyte Uhawenayo", "Albert Nsanzimana", "Samuel Byiringiro", "Emery Manirambona", "Emmanuel Uwiringiyimana" ]	Maternal mortality remains critically high in low- and middle-income countries (LMIC), particularly in sub-Saharan Africa. Rwanda’s leading causes of maternal death include postpartum hemorrhage and obstructed labor. Maternal recognition of obstetrical danger signs is critical for timely access to emergency care to red...	10.1371/journal.pgph.0001084	[]	[{"citation_id": "pgph.0001084.ref001", "related_text": ["The complications from pregnancy and childbirth are the leading causes of maternal deaths in low- and middle-income countries (LMIC) [1–3]. Half of all maternal deaths result from postpartum hemorrhage (27%), hypertensive disorders (14%), and sepsis (11%) [1]. E...	{"introduction": "The complications from pregnancy and childbirth are the leading causes of maternal deaths in low- and middle-income countries (LMIC) [1–3]. Half of all maternal deaths result from postpartum hemorrhage (27%), hypertensive disorders (14%), and sepsis (11%) [1]. Evidence shows that most maternal complic...	[{"id": "", "caption": "", "related_text": "Regarding the source of ODS information, 176 (46.1%) got information from nurses and midwives, 119 (31.2%) from fellow mothers, and 79 (20.7%) from community health workers (Fig 2).", "image_candidates": ["pgph.0001084.g002"]}, {"id": "", "caption": "", "related_text": "Overa...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021421	Optimal use of COVID-19 Ag-RDT screening at border crossings to prevent community transmission: A modeling analysis	[ "Brooke E. Nichols", "Sergio Carmona", "Emma Hannay", "Amy Toporowski", "Heidi Albert", "Shaukat Khan", "Sarah J. Girdwood", "Karla Therese L. Sy", "Joshua M. Chevalier" ]	Countries around the world have implemented restrictions on mobility, especially cross-border travel to reduce or prevent SARS-CoV-2 community transmission. Rapid antigen testing (Ag-RDT), with on-site administration and rapid turnaround time may provide a valuable screening measure to ease cross-border travel while mi...	10.1371/journal.pgph.0000086	[]	[{"citation_id": "pgph.0000086.ref001", "related_text": ["Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, first emerged in Wuhan, China in late 2019. Aided by globalization, the novel coronavirus quickly spread to countries around the world. On the 11th of March 2020, COVI...	{"introduction": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, first emerged in Wuhan, China in late 2019. Aided by globalization, the novel coronavirus quickly spread to countries around the world. On the 11th of March 2020, COVID-19 was officially declared a global pa...	[{"id": "", "caption": "", "related_text": "Figs 2–5 maintain recipient country prevalence at 0.1% as this more closely reflects the case numbers seen between epidemic waves when travel to the country would be most likely. In Fig 6 we demonstrate the impact of increasing recipient country prevalence on the daily maximu...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" colspan=\"1\">Parameter</th><th align=\"center\" rowspan=\"1\" colspan=\...
PMC10021431	Safety and immunogenicity of a reduced dose of the BNT162b2 mRNA COVID-19 vaccine (REDU-VAC): A single blind, randomized, non-inferiority trial	[ "Maria E. Goossens", "Kevin K. Ariën", "Isabelle Desombere", "Arnaud Marchant", "Katelijne Dierick", "Steven Van Gucht", "Marie-Noëlle Schmickler", "Mathieu Verbrugghe", "Alexandra Waegemans", "Véronique Olislagers", "Félicie Chaumont", "Antoine Francotte", "Stéphane De Craeye", "Elisabeth...	Fractional dosing of COVID-19 vaccines could accelerate vaccination rates in low-income countries. Dose-finding studies of the mRNA vaccine BNT162b2 (Pfizer-BioNTech) suggest that a fractional dose induces comparable antibody responses to the full dose in people <55 years. Here, we report the safety and immunogenicity ...	10.1371/journal.pgph.0001308	[]	[{"citation_id": "pgph.0001308.ref001", "related_text": ["Today, less than 22% of people in low-income countries (LIC) have been vaccinated against COVID-19 with at least one dose, compared to 72% in high-income countries [1]. Besides allowing the emergence of new SARS-CoV-2 variants and their subsequent spread around ...	{"introduction": "Today, less than 22% of people in low-income countries (LIC) have been vaccinated against COVID-19 with at least one dose, compared to 72% in high-income countries [1]. Besides allowing the emergence of new SARS-CoV-2 variants and their subsequent spread around the world, this blatant inequity in glob...	[{"id": "", "caption": "SARS-CoV-2 anti-RBD IgG binding antibody data are shown on days 0/21/49 and month 6 post first dose (A), SARS-CoV-2 Wuhan neutralizing antibodies on days 21/49 (B) and SARS-CoV-2 Delta (C) and Omicron (D) neutralizing antibodies on day 49 per study arm (purple = 20μg, black = 30μg). In the case ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021447	Long-term effects of increased adoption of artemisinin combination therapies in Burkina Faso	[ "Maciej F. Boni", "Jean-Bosco Ouédraogo", "Amy Wesolowski", "Kien Trung Tran", "Dang Duy Hoang Giang", "Patrick Dudas", "Jaline Gerardin", "Thu Nguyen-Anh Tran", "Anyirékun Fabrice Somé", "Tran Dang Nguyen", "Robert J. Zupko" ]	Artemisinin combination therapies (ACTs) are the WHO-recommended first-line therapies for uncomplicated Plasmodium falciparum malaria. The emergence and spread of artemisinin-resistant genotypes is a major global public health concern due to the increased rate of treatment failures that result. This is particularly ger...	10.1371/journal.pgph.0000111	[]	[{"citation_id": "pgph.0000111.ref001", "related_text": ["Despite the United Nations’ Millennium Development Goals leading to substantial reductions in the global burden of infectious disease, malaria remains a serious public health risk in many parts of Africa, Asia, and South America. Plasmodium falciparum malaria re...	{"introduction": "Despite the United Nations’ Millennium Development Goals leading to substantial reductions in the global burden of infectious disease, malaria remains a serious public health risk in many parts of Africa, Asia, and South America. Plasmodium falciparum malaria remains holoendemic in at least eleven cou...	[{"id": "", "caption": "The impact of changing the role of DHA-PPQ in an MFT policy. Lower DHA-PPQ use results in weaker selection pressure on 580Y alleles. The loss of PPQ efficacy due to plasmepsin-2,3 double-copy emergence influences the rate at which the 580Y frequency increases.", "related_text": "To further inves...	[{"caption": "Note that all policy interventions result in a higher 580Y frequency compared to the status quo scenario, but this may be offset by reductions in the treatment failure rate for some policies. Note that the MFT scenarios assume rapid private market (PM) elimination and that unless otherwise specified the M...
PMC10021451	Economic evaluation of a cluster randomized, non-inferiority trial of differentiated service delivery models of HIV treatment in Zimbabwe	[ "Sydney Rosen", "Ashraf Grimwood", "Nicoletta Mabhena-Ngorima", "Kudakwashe Takarinda", "Salome Kuchukhidze", "Geoffrey Fatti", "Brooke E. Nichols", "Mariet Benade" ]	About 85% of Zimbabwe’s >1.4 million people living with HIV are on antiretroviral treatment (ART). Further expansion of its treatment program will require more efficient use of existing resources. Two promising strategies for reducing resource utilization per patient are multi-month medication dispensing and community-...	10.1371/journal.pgph.0000493	[]	[{"citation_id": "pgph.0000493.ref001", "related_text": ["Zimbabwe, a country in southern Africa of just under 15 million people, has a high burden of HIV infection, with a prevalence of more than 10% among adults [1, 2]. Great progress has been made in expanding access to testing and treatment, care, with an estimated...	{"introduction": "Zimbabwe, a country in southern Africa of just under 15 million people, has a high burden of HIV infection, with a prevalence of more than 10% among adults [1, 2]. Great progress has been made in expanding access to testing and treatment, care, with an estimated 78% of all people living with HIV (PLHI...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021455	COVID-19 vaccine hesitancy and confidence in the Philippines and Malaysia: A cross-sectional study of sociodemographic factors and digital health literacy	[ "Tin T. Su", "Mark E. Patalinghug", "Michael G. Head", "Rafidah Bahari", "Roy R. Marzo", "Ken Brackstone" ]	With the emergence of the highly transmissible Omicron variant, large-scale vaccination coverage is crucial to the national and global pandemic response, especially in populous Southeast Asian countries such as the Philippines and Malaysia where new information is often received digitally. The main aims of this researc...	10.1371/journal.pgph.0000742	[]	[{"citation_id": "pgph.0000742.ref001", "related_text": ["While many high-income settings have achieved relatively high coverage with their COVID-19 vaccination campaigns, almost 32.1% of the world’s population have not received a single dose of any COVID-19 vaccine as of July 2022 [1]. The Philippines and Malaysia are...	{"introduction": "While many high-income settings have achieved relatively high coverage with their COVID-19 vaccination campaigns, almost 32.1% of the world’s population have not received a single dose of any COVID-19 vaccine as of July 2022 [1]. The Philippines and Malaysia are among two of the most populous countrie...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021468	Effective pandemic policy design through feedback does not need accurate predictions	[ "Guy A. Dumont", "Sarah P. Otto", "Greg E. Stewart", "Klaske van Heusden" ]	The COVID-19 pandemic has had an enormous toll on human health and well-being and led to major social and economic disruptions. Public health interventions in response to burgeoning case numbers and hospitalizations have repeatedly bent down the epidemic curve, effectively creating a feedback control system. Worst case...	10.1371/journal.pgph.0000955	[]	[{"citation_id": "pgph.0000955.ref001", "related_text": ["With almost 500 million reported cases and over 6.2 million deaths (WHO dashboard, accessed May 17, 2022), the COVID-19 pandemic has placed an enormous burden on individuals, health systems, and society. In order to reduce the rate of transmission of the disease...	{"introduction": "With almost 500 million reported cases and over 6.2 million deaths (WHO dashboard, accessed May 17, 2022), the COVID-19 pandemic has placed an enormous burden on individuals, health systems, and society. In order to reduce the rate of transmission of the disease, most countries have implemented simila...	[{"id": "", "caption": "Left: A new variant that is 2.5 times more infectious (R0v = 7.5, introduced after 425 days indicated by a light blue dashed line) causes an initial increase in infections (dark orange line). Feedback control compensates with stricter measures that lead to extinction of the original strain (ligh...	[]
PMC10021477	Availability of priority maternal and newborn health indicators: Cross-sectional analysis of pregnancy, childbirth and postnatal care registers from 21 countries	[ "Allisyn Carol Moran", "Elizabeth Katwan", "Francesca Palestra", "Mark M. Kabue" ]	Data from national health information systems are essential for routinely tracking progress, programmatic decision-making and to improve quality of services. Understanding the data elements captured in patient registers which are building blocks of national HMIS indicators, enables us to standardize data collection and...	10.1371/journal.pgph.0000739	[]	[{"citation_id": "pgph.0000739.ref001", "related_text": ["The global burden of maternal deaths is estimated at 810 women dying each day from preventable conditions related to pregnancy and childbirth [1,2]. Although there was 38% reduction in the maternal mortality ratio (MMR) between 2000 and 2017, the current MMR of ...	{"introduction": "The global burden of maternal deaths is estimated at 810 women dying each day from preventable conditions related to pregnancy and childbirth [1,2]. Although there was 38% reduction in the maternal mortality ratio (MMR) between 2000 and 2017, the current MMR of 211 deaths per 100,000 live births remai...	[{"id": "", "caption": "", "related_text": "Use of a uterotonic (Oxytocin, Ergometrine or Misoprostol) immediately after delivery is documented in 11/18 (61%) countries, while use of magnesium sulphate in the management of pre-eclampsia/ Eclampsia is recorded in three countries. Complications of childbirth are document...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021506	Mapping climate change’s impact on cholera infection risk in Bangladesh	[ "Kenichi W. Okamoto", "Paul A. Lorah", "Sophia E. Kruger" ]	Several studies have investigated how Vibrio cholerae infection risk changes with increased rainfall, temperature, and water pH levels for coastal Bangladesh, which experiences seasonal surges in cholera infections associated with heavy rainfall events. While coastal environmental conditions are understood to influence...	10.1371/journal.pgph.0000711	[]	[{"citation_id": "pgph.0000711.ref001", "related_text": ["Cholera, a waterborne bacterial disease that causes severe diarrhea and dehydration in humans, remains a significant threat to global health. Despite proposed efforts to reduce global cholera mortality by 90% by 2030 [1], researchers estimate that between 1.3 mi...	{"introduction": "Cholera, a waterborne bacterial disease that causes severe diarrhea and dehydration in humans, remains a significant threat to global health. Despite proposed efforts to reduce global cholera mortality by 90% by 2030 [1], researchers estimate that between 1.3 million and 4 million cholera cases occur ...	[{"id": "", "caption": "Areas of ‘high risk’ are designated as those with an average occurrence probability of 0.50 or greater. High risk areas for 2015 (yellow), 2050 (grey), and both 2015 and 2050 (red), as predicted by the bivariate random forest model with elevation and distance to water as predictors, are included...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" style=\"background-color:#D9D9D9\" ...
PMC10021516	Factors associated with the uptake of Intermittent Preventive Treatment (IPTp-SP) for malaria in pregnancy: Further analysis of the 2018 Nigeria Demographic and Health Survey	[ "Juliana Kagura", "Tobias Chirwa", "Latifat Ibisomi", "Joel Msafiri Francis", "Godwin Okeke Kalu" ]	Pregnancy-associated malaria is preventable and curable with intermittent preventive treatment with Sulfodoxine-Pyrimethamine (IPTp-SP). However, despite the effectiveness of IPTp-SP against malaria in pregnancy, the uptake among pregnant women in Nigeria remains very low. Thus, this study aimed to establish the factor...	10.1371/journal.pgph.0000771	[]	[{"citation_id": "pgph.0000771.ref001", "related_text": ["Globally, about 1.7 billion malaria cases and 10.6 million malaria-related deaths were averted in the past two decades [1]. The rate of malaria-related deaths per 100,000 population at risk declined from 25 in 2000 to 12 in 2015 and 10 in 2019 [2]. Equally, the ...	{"introduction": "Globally, about 1.7 billion malaria cases and 10.6 million malaria-related deaths were averted in the past two decades [1]. The rate of malaria-related deaths per 100,000 population at risk declined from 25 in 2000 to 12 in 2015 and 10 in 2019 [2]. Equally, the estimated number of deaths decreased fro...	[{"id": "", "caption": "", "related_text": "From the survey sampling frame, 41,821 women of childbearing ages (15 to 49 years) were interviewed. Among these women, 12,935 had live births during or two years preceding the 2018 NDHS. Of these, data from 12,742 women were extracted, who reported to have received and known...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021523	Integrating isoniazid preventive therapy into the fast-track HIV treatment model in urban Zambia: A proof-of -concept pilot project	[ "Priscilla Lumano Mulenga", "Patrick Lingu", "Lloyd Mulenga", "Prisca Kasonde", "Khunga Morton", "Anjali Sharma", "Samuel Bosomprah", "Carolyn Bolton-Moore", "Peter Preko", "Felix Mwanza", "Fred Chungu", "Felton Mpesela", "Miriam Rabkin", "Linah Kampilimba Mwango", "Estella Kalunkumya", ...	Most people living with HIV (PLHIV) established on treatment in Zambia receive multi-month prescribing and dispensing (MMSD) antiretroviral therapy (ART) and are enrolled in less-intensive differentiated service delivery (DSD) models such as Fast Track (FT), where clients collect ART every 3–6 months and make clinical ...	10.1371/journal.pgph.0000909	[]	[{"citation_id": "pgph.0000909.ref001", "related_text": ["Globally, tuberculosis (TB) is the direct cause of one-third of all human immunodeficiency virus (HIV) related deaths and the leading cause of death among people living with HIV (PLHIV) [1]. PLHIV account for approximately 10% of the 10 million annual new TB cas...	{"introduction": "Globally, tuberculosis (TB) is the direct cause of one-third of all human immunodeficiency virus (HIV) related deaths and the leading cause of death among people living with HIV (PLHIV) [1]. PLHIV account for approximately 10% of the 10 million annual new TB cases and on average, have about 21-fold (C...	[{"id": "", "caption": "", "related_text": "Sixty-six participants (8.1%) reported side effects, with insignificant differences by age, sex, or duration on ART (Table 1). Reported side effects were frequent in the early weeks of IPT initiation (Fig 6). Whilst none of the side effects were classified as serious accordin...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021528	A sliding window approach to optimize the time-varying parameters of a spatially-explicit and stochastic model of COVID-19	[ "Joseph R. Mihaljevic", "Eck Doerry", "Crystal Hepp", "Saikanth Ratnavale" ]	The implementation of non-pharmaceutical public health interventions can have simultaneous impacts on pathogen transmission rates as well as host mobility rates. For instance, with SARS-CoV-2, masking can influence host-to-host transmission, while stay-at-home orders can influence mobility. Importantly, variations in t...	10.1371/journal.pgph.0001058	[]	[{"citation_id": "pgph.0001058.ref001", "related_text": ["In March 2020, the World Health Organization announced that the spread of SARS-CoV-2 virus–the etiological agent of COVID-19 –was officially a pandemic. Various preventive measures such as social distancing, wearing masks, and stay-at-home orders were recommende...	{"introduction": "In March 2020, the World Health Organization announced that the spread of SARS-CoV-2 virus–the etiological agent of COVID-19 –was officially a pandemic. Various preventive measures such as social distancing, wearing masks, and stay-at-home orders were recommended to contain the outbreak throughout the...	[{"id": "", "caption": "", "related_text": "In general, our model-fitting routine does a very good job of accurately recovering weekly-varying values of the transmission rate βt, regardless of whether the movement rate mt is known (fixed) or simultaneously estimated (Figs 5–7). Additionally, in all scenarios, the model...	[]
PMC10021539	Collecting mortality data via mobile phone surveys: A non-inferiority randomized trial in Malawi	[ "Stéphane Helleringer", "Boniface Dulani", "Georges Reniers", "Malebogo Tlhajoane", "Jacob Saikolo", "Mathero M. Nkhalamba", "Funny Muthema", "Augustine T. Choko", "Michael Chasukwa" ]	Despite the urgent need for timely mortality data in low-income and lower-middle-income countries, mobile phone surveys rarely include questions about recent deaths. Such questions might a) be too sensitive, b) take too long to ask and/or c) generate unreliable data. We assessed the feasibility of mortality data collec...	10.1371/journal.pgph.0000852	[]	[{"citation_id": "pgph.0000852.ref001", "related_text": ["In many low-income and lower-middle-income countries (LLMICs), few deaths are registered with competent administrative authorities in a timely manner [1–3]. In such settings, mortality statistics are only updated every few years, after periodic household surveys...	{"introduction": "In many low-income and lower-middle-income countries (LLMICs), few deaths are registered with competent administrative authorities in a timely manner [1–3]. In such settings, mortality statistics are only updated every few years, after periodic household surveys or censuses are conducted. The retrospe...	[{"id": "", "caption": "Notes: In Panel A), error bars represent 95% exact confidence intervals. The difference in the likelihood of missing data on age at death by source of report was significant at the p<0.05 level. In Panel B), Q1 refers to the first quarter of a year, i.e., January, February and March. Two deaths ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th...
PMC10021545	Urban pandemic response: Survey results describing the experiences from twenty-five cities during the COVID-19 pandemic	[ "Ariella Rojhani", "Amanda McClelland", "Breanna van Loenen", "Melissa Cordoba Asprilla", "Matthew R. Boyce" ]	Since first being detected in Wuhan, China in late December 2019, COVID-19 has demanded a response from all levels of government. While the role of local governments in routine public health functions is well understood–and the response to the pandemic has highlighted the importance of involving local governments in th...	10.1371/journal.pgph.0000859	[]	[{"citation_id": "pgph.0000859.ref001", "related_text": ["On December 31, 2019, the World Health Organization (WHO) China country office was notified about a series of pneumonia cases of unknown etiology in the city of Wuhan, Hubei Province [1]. Over the next several weeks, cases were confirmed in Thailand (January 12,...	{"introduction": "On December 31, 2019, the World Health Organization (WHO) China country office was notified about a series of pneumonia cases of unknown etiology in the city of Wuhan, Hubei Province [1]. Over the next several weeks, cases were confirmed in Thailand (January 12, 2020), Japan (January 15, 2020), South ...	[{"id": "", "caption": "", "related_text": "When asked about specific risk communication activities, survey responses showed that reaching high-risk populations with information and addressing misinformation and disinformation were the two most challenging activities, with at least half of study participants characteri...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021553	COVID-19 vaccine acceptance among healthcare workers in India: Results from a cross-sectional survey	[ "Anita Shet", "Madhu Gupta", "Paramita Sengupta", "Preetika Banerjee", "Stacie Loisate", "Sanjay Zodpey", "Baldeep K. Dhaliwal", "Kayur Mehta" ]	Remarkable scientific progress has enabled expeditious development of effective vaccines against COVID-19. While healthcare workers (HCWs) have been at the frontline of the pandemic response, vaccine acceptance amongst them needs further study. We conducted a web-based survey to assess vaccine acceptance among HCWs in ...	10.1371/journal.pgph.0000661	[]	[{"citation_id": "pgph.0000661.ref001", "related_text": ["After first emerging in late 2019 [1], the SARS-CoV-2 virus which causes COVID-19 has spread across the world and achieved pandemic status in March 2020. In the absence of pharmaceutical interventions, population-wide lockdowns and social distancing measures wer...	{"introduction": "After first emerging in late 2019 [1], the SARS-CoV-2 virus which causes COVID-19 has spread across the world and achieved pandemic status in March 2020. In the absence of pharmaceutical interventions, population-wide lockdowns and social distancing measures were enforced to slow the spread of the vir...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021556	Definitions matter: Heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis	[ "Nicholas J. White", "Nathalie Strub-Wourgaft", "James A. Watson", "AbdulAzeez Lawal", "Sumayyah Rashan", "Alistair R. D. McLean", "Philippe J. Guérin" ]	Therapeutic efficacy in COVID-19 is dependent upon disease severity (treatment effect heterogeneity). Unfortunately, definitions of severity vary widely. This compromises the meta-analysis of randomised controlled trials (RCTs) and the therapeutic guidelines derived from them. The World Health Organisation ‘living’ gui...	10.1371/journal.pgph.0000561	[]	[{"citation_id": "pgph.0000561.ref001", "related_text": ["Viral burdens in COVID-19 infection peak early, around the time of symptom onset, and then decline. In the minority of patients requiring hospitalisation and respiratory support, inflammatory processes dominate [1,2]. As a result, drugs used to treat COVID-19 ma...	{"introduction": "Viral burdens in COVID-19 infection peak early, around the time of symptom onset, and then decline. In the minority of patients requiring hospitalisation and respiratory support, inflammatory processes dominate [1,2]. As a result, drugs used to treat COVID-19 may have varying efficacy depending on whe...	[{"id": "", "caption": "", "related_text": "The slow global roll-out of vaccines and the threat of new variants means that effective therapeutics are still needed urgently. Most therapeutic trials on COVID-19 have been on hospitalised patients and most trials reported to date contain insufficient information to classif...	[]
PMC10021563	Acceptability and associated factors of indoor residual spraying for malaria control by households in Luangwa district of Zambia: A multilevel analysis	[ "Choolwe Jacobs", "Joseph Lupenga", "Jessy Zgambo", "Charles Michelo", "Patrick Kaonga", "Maureen Aongola" ]	The global burden of malaria has increased from 227 million cases in 2019 to 247 million cases in 2020. Indoor residual spraying (IRS) remains one of the most effective control strategies for malaria. The current study sought to measure the acceptability level and associated factors of indoor residual spraying. A cross...	10.1371/journal.pgph.0000368	[]	[{"citation_id": "pgph.0000368.ref001", "related_text": ["Malaria still remains a global public health problem with an estimated 241 million malaria cases in 2020 in 85 malaria endemic countries increasing from 227 million in 2019, with most of this increase coming from countries in the WHO African Region [1]. Malaria ...	{"introduction": "Malaria still remains a global public health problem with an estimated 241 million malaria cases in 2020 in 85 malaria endemic countries increasing from 227 million in 2019, with most of this increase coming from countries in the WHO African Region [1]. Malaria is endemic in Zambia despite massive sca...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021578	Factors influencing the motivation of maternal health workers in conflict setting of Mogadishu, Somalia	[ "Abdi Gele", "Naima Said Sheikh" ]	Motivated health workers play an important role in delivering high-quality maternal health services, especially in low-income countries where maternal mortality rates are high, and shortages of human resource for health is prevalent. The aim of this study is to investigate maternal health workers’ motivation in three t...	10.1371/journal.pgph.0001673	[]	[{"citation_id": "pgph.0001673.ref001", "related_text": ["The large burden of mother and child mortality in Sub-Saharan Africa has been associated with inadequate health worker performance [1]. According to the World Health Organization (WHO), African countries have the lowest health worker-to-population ratio in the w...	{"introduction": "The large burden of mother and child mortality in Sub-Saharan Africa has been associated with inadequate health worker performance [1]. According to the World Health Organization (WHO), African countries have the lowest health worker-to-population ratio in the world [2]. An estimated shortage of 4.3 m...	[]	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021582	The impact of sampling bias on viral phylogeographic reconstruction	[ "Ailene MacPherson", "Caroline Colijn", "Yexuan Song", "Pengyu Liu" ]	Genomic epidemiology plays an ever-increasing role in our understanding of and response to the spread of infectious pathogens. Phylogeography, the reconstruction of the historical location and movement of pathogens from the evolutionary relationships among sampled pathogen sequences, can inform policy decisions related...	10.1371/journal.pgph.0000577	[]	[{"citation_id": "pgph.0000577.ref001", "related_text": ["Genomic epidemiology refers to the use of pathogen genomes to understand how infectious diseases are transmitted across a range of scales, from local outbreaks to global geographic spread. Due to improvements in sequencing technology and decreasing cost, genomic...	{"introduction": "Genomic epidemiology refers to the use of pathogen genomes to understand how infectious diseases are transmitted across a range of scales, from local outbreaks to global geographic spread. Due to improvements in sequencing technology and decreasing cost, genomic epidemiology has increased greatly in s...	[{"id": "", "caption": "Panel A: The Maximum Clade Credibility (MCC) tree of Ebolavirus sequences generated using BEAST, which is used as the true tree. Downsampled trees obtained by dropping 80% recent migrants with either the true ancestral locations (Panel A) or ancestral locations reconstructed after downsmapling m...	[{"caption": "Likelihood of the parent node and the child node of a migration event in the gray box being at each location before and after downsampling recent migrants.", "content": "<table frame=\"box\" rules=\"all\" border=\"0\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"lef...
PMC10021594	Prevalence and risk factors of short birth interval in Bangladesh: Evidence from the linked data of population and health facility survey	[ "Md. Nuruzzaman Khan", "Md. Mostafizur Rahman", "M. Mofizul Islam", "Mohammad Zahidul Islam" ]	The Sustainable Development Goals 3 targets significant reductions in maternal and under-five deaths by 2030. The prevalence of these deaths is significantly associated with short birth intervals (SBI). Identification of factors associated with SBI is pivotal for intervening with appropriate programmes to reduce occurr...	10.1371/journal.pgph.0000288	[]	[{"citation_id": "pgph.0000288.ref001", "related_text": ["The World Health Organization (WHO) recommends at least 24 months interval between a live birth or termination to the next conception or 33 months interval between a live birth or termination to the next live birth [1]. The intervals shorter than these durations...	{"introduction": "The World Health Organization (WHO) recommends at least 24 months interval between a live birth or termination to the next conception or 33 months interval between a live birth or termination to the next live birth [1]. The intervals shorter than these durations are considered as short birth intervals...	[{"id": "", "caption": "", "related_text": "We calculated the age-standardised prevalence of SBI across regions in Bangladesh (Fig 1, results not shown in the table) as there were substantial variations in the prevalences of SBI in Bangladesh across different age-groups of women. The distribution of women aged 15–49 in...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021625	The impact of a demand-side sanitation and hygiene promotion intervention on sustained behavior change and health in Amhara, Ethiopia: A cluster-randomized trial	[ "Abebe Gebremariam Gobezayehu", "Kassahun Zewudie", "Mulat Woreta", "Yihenew Tesfaye", "Gloria D. Sclar", "Thomas F. Clasen", "Bethany A. Caruso", "Mulusew Belew", "Joshua V. Garn", "Jedidiah S. Snyder", "Maryann G. Delea", "Matthew C. Freeman" ]	Behaviors related to water, sanitation, and hygiene (WASH) are key drivers of infectious disease transmission, and experiences of WASH are potential influencers of mental well-being. Important knowledge gaps exist related to the content and delivery of effective WASH programs and their associated health impacts, partic...	10.1371/journal.pgph.0000056	[]	[{"citation_id": "pgph.0000056.ref001", "related_text": ["Inadequate water, sanitation, and hygiene (WASH) are key drivers of infectious disease transmission [1, 2]. Diarrhea accounts for an estimated 1.65 million deaths annually [3] and nearly 10% of all under-5 deaths in low-income settings [4]. Deficiencies in WASH ...	{"introduction": "Inadequate water, sanitation, and hygiene (WASH) are key drivers of infectious disease transmission [1, 2]. Diarrhea accounts for an estimated 1.65 million deaths annually [3] and nearly 10% of all under-5 deaths in low-income settings [4]. Deficiencies in WASH are also a major contributor of neglecte...	[{"id": "", "caption": "", "related_text": "There was little difference in the sustainability of key targeted indicators—assessed by changes between midline and endline—on sanitation access and practices, personal hygiene access and practices, and household environmental sanitation over the course of follow up (Fig 4)....	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021629	Increased adverse events following third dose of BNT162b2/Pfizer vaccine in those with previous COVID-19, but not with concurrent influenza vaccine	[ "David R. Chadwick", "Jon Rees", "Rachael K. Raw" ]	Prior studies suggest that adverse events (AEs) following doses one and two of BNT162b2/Pfizer vaccine are worse in those with a prior history of COVID-19. To establish whether this outcome applies to a third/booster dose, we conducted a survey with 534 healthcare workers (HCW) in Northeast England, who reported AEs fo...	10.1371/journal.pgph.0001053	[]	[{"citation_id": "pgph.0001053.ref001", "related_text": ["Global vaccination efforts against SARS-CoV-2 began in late 2020, with BNT162b2/Pfizer [1], mRNA-1273/Moderna [2], and ChAdOx1/AstraZeneca [3] vaccines applied predominantly in the UK population. Healthcare Workers (HCWs) have been a priority target group. Phase...	{"introduction": "Global vaccination efforts against SARS-CoV-2 began in late 2020, with BNT162b2/Pfizer [1], mRNA-1273/Moderna [2], and ChAdOx1/AstraZeneca [3] vaccines applied predominantly in the UK population. Healthcare Workers (HCWs) have been a priority target group. Phase three trials demonstrated general safet...	[{"id": "", "caption": "N & V: nausea and vomiting.", "related_text": "Incidence of each type of AE following BNT162b2/Pfizer dose three for those with and without prior COVID-19, is shown in Table 2. As in our previous work, the cluster of headache, fatigue, myalgia and arthralgia were most common in HCWs with prior C...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" colspan=\"1\" /><th a...
PMC10021650	Fast Evaluation of Viral Emerging Risks (FEVER): A computational tool for biosurveillance, diagnostics, and mutation typing of emerging viral pathogens	[ "Jessica Z. Kubicek-Sutherland", "Karina Yusim", "Harshini Mukundan", "Jason Mitchell", "Ebany J. Martinez-Finley", "Alina Deshpande", "Jason Gans", "Samantha J. Courtney", "Attelia Hollander", "Adán Myers y Gutiérrez", "Brian T. Foley", "James Theiler", "Zachary R. Stromberg" ]	Viral pathogens can rapidly evolve, adapt to novel hosts, and evade human immunity. The early detection of emerging viral pathogens through biosurveillance coupled with rapid and accurate diagnostics are required to mitigate global pandemics. However, RNA viruses can mutate rapidly, hampering biosurveillance and diagno...	10.1371/journal.pgph.0000207	[]	[{"citation_id": "pgph.0000207.ref001", "related_text": ["In the last decade, several RNA viruses have emerged from animal reservoirs to threaten global public health [1]. These viruses include influenza A in 2009 [2], Ebola in 2013 [3], Chikungunya in 2014 [4], Zika in 2015 [5], and severe acute respiratory syndrome c...	{"introduction": "In the last decade, several RNA viruses have emerged from animal reservoirs to threaten global public health [1]. These viruses include influenza A in 2009 [2], Ebola in 2013 [3], Chikungunya in 2014 [4], Zika in 2015 [5], and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) most recently ...	[{"id": "", "caption": "The U.S. CDC N1 cycle threshold (CT) values were compared to (a) FEVER_5’UTR, (b) FEVER_Env, (c) FEVER_ORF1ab, and (d) FEVER_Spike RT-PCR assays CT values (blue dots). The U.S. CDC N2 CT values were compared to (e) FEVER_5’UTR, (f) FEVER_Env, (g) FEVER_ORF1ab, and (h) FEVER_Spike RT-PCR assays C...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valig...
PMC10021656	Measures to assess quality of postnatal care: A scoping review	[ "Ann-Beth Moller", "Bianca De Sá é Silva", "Godwin Kwaku Tuabu", "Louise Tina Day", "Anayda Portela", "Moise Muzigaba", "Katriona Graham", "Mercedes Bonet", "Allisyn C. Moran", "Anna Galle" ]	High quality postnatal care is key for the health and wellbeing of women after childbirth and their newborns. In 2022, the World Health Organization (WHO) published global recommendations on maternal and newborn care for a positive postnatal care experience in a new WHO PNC guideline. Evidence regarding appropriate mea...	10.1371/journal.pgph.0001384	[]	[{"citation_id": "pgph.0001384.ref001", "related_text": ["The days and weeks following childbirth – the postnatal period – is a critical time for women and newborns [1]. Major physical, social and emotional changes occur during this period, yet this is often the most neglected period on the continuum of maternal and ne...	{"introduction": "The days and weeks following childbirth – the postnatal period – is a critical time for women and newborns [1]. Major physical, social and emotional changes occur during this period, yet this is often the most neglected period on the continuum of maternal and newborn care, challenged by the fragmentat...	[{"id": "", "caption": "Legend: AUC=Area Under the receiver operating characteristic Curve; CFA=Confirmatory Factor Analysis.", "related_text": "In 24 out of 62 studies (39%) the authors conducted a validity assessment of the used quality of care measure. Methods used in the different studies to validate indicators or ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" colspan=\"1\">EXPERIE...
PMC10021691	Rural prioritization may increase the impact of COVID-19 vaccines in a representative COVAX AMC country setting due to ongoing internal migration: A modeling study	[ "Stewart T. Chang", "Nicholas Jackson", "J. Gabrielle Breugelmans", "Maïna L’Azou Jackson", "Dennis L. Chao", "Bradley G. Wagner", "Prashanth Selvaraj" ]	How COVID-19 vaccine is distributed within low- and middle-income countries has received little attention outside of equity or logistical concerns but may ultimately affect campaign impact in terms of infections, severe cases, or deaths averted. In this study we examined whether subnational (urban-rural) prioritization...	10.1371/journal.pgph.0000053	[]	[{"citation_id": "pgph.0000053.ref001", "related_text": ["COVID-19 has presented every country with a challenge to formulate a strategy to protect its population, initially with non-pharmaceutical interventions (NPI)/public health and safety measures (PHSM) and more recently vaccination. As of June 2021, the World Heal...	{"introduction": "COVID-19 has presented every country with a challenge to formulate a strategy to protect its population, initially with non-pharmaceutical interventions (NPI)/public health and safety measures (PHSM) and more recently vaccination. As of June 2021, the World Health Organization (WHO) has granted Emerge...	[{"id": "", "caption": "Bars indicate mean reduction in respective cumulative indicator, and error bars indicate standard error.", "related_text": "In all three transmission scenarios in Fig 10 as well as the remaining scenarios (S1 Appendix), increased NPI/PHSM that also reduced migration maximized the impact of vacci...	[{"caption": "Calendar day 0 = January 1, 2020.", "content": "<table frame=\"box\" rules=\"all\" border=\"0\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"le...
PMC10021706	COVID-19 vaccine brand hesitancy and other challenges to vaccination in the Philippines	[ "Manuel M. Dayrit", "Lourdes Sumpaico-Tanchanco", "Veincent Christian F. Pepito", "Arianna Maever L. Amit" ]	Effective and safe COVID-19 vaccines have been developed at a rapid and unprecedented pace to control the spread of the virus, and prevent hospitalisations and deaths. However, COVID-19 vaccine uptake is challenged by vaccine hesitancy and anti-vaccination sentiments, a global shortage of vaccine supply, and inequitabl...	10.1371/journal.pgph.0000165	[]	[{"citation_id": "pgph.0000165.ref001", "related_text": ["The coronavirus disease 2019 (COVID-19) pandemic continues to burden health systems and communities globally, with millions of cases and deaths [1]. Because of the significant and continued impact of COVID-19, vaccines have been developed at a rapid and unpreced...	{"introduction": "The coronavirus disease 2019 (COVID-19) pandemic continues to burden health systems and communities globally, with millions of cases and deaths [1]. Because of the significant and continued impact of COVID-19, vaccines have been developed at a rapid and unprecedented pace to control the spread of the ...	[{"id": "", "caption": "This figure shows the three main tiers of factors influencing vaccination intention and uptake: individual (beliefs, attitudes, knowledge, health literacy), interpersonal (relationships, networks), and structural (health systems and service delivery, media, policies). These three dimensions are ...	[{"caption": "", "content": "<table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /><col align=\"left\" valign=\"middle\" span=\"1\" /></colgroup><thead><tr><th align=\"left\" rowspan=\"1\" colspan=\"1\">Quote I...

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