| Trigger,Disease,Number of death,Global population lost,Regional population lost,Date,Origin | |
| 1957–1958 influenza pandemic,Influenza A/H2N2,1–4 million,0.03–0.1%,,1957–1958,Worldwide | |
| Antonine Plague,Smallpox or measles,5–10 million,,25–33% of Roman population,,Roman Empire | |
| 1629–1631 Italian plague,Bubonic plague,1 million,0.2%,,1629–1631,Italy | |
| Black Death,Bubonic plague,75–200 million,17–54%,30–60% of European population,,"Europe, Asia, and North Africa" | |
| COVID-19 pandemic,COVID-19,6.1–24.4 million,0.1–0.3%,–,,Worldwide | |
| 1846–1860 cholera pandemic,Cholera,,,,, | |
| 1889–1890 flu pandemic,Influenza,1 million,0.07%,,1889–1890,Worldwide | |
| Hong Kong flu,Influenza A/H3N2,1–4 million,0.03–0.1%,,1968–1969,Worldwide | |
| 1772–1773 Persian Plague,Bubonic plague,2 million,,,1772–1773, | |
| 735–737 Japanese smallpox epidemic,Smallpox,,1%,33% of Japanese population,735–737,Japan | |
| Third plague pandemic,Bubonic plague,12–15 million,,,,Worldwide | |
| Plague of Justinian,Bubonic plague,15–100 million,7–56%,25–60% of European population,,"North Africa, Europe and West Asia" | |
| Spanish flu,Influenza A/H1N1,17–100 million,1–5.4%,–,,Worldwide | |
| Naples Plague,Bubonic plague,,0.2%,,1656–1658,Southern Italy | |