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PMC4606567
An automated shotgun lipidomics platform for high throughput, comprehensive, and quantitative analysis of blood plasma intact lipids
Blood plasma has gained protagonism in lipidomics studies due to its availability, uncomplicated collection and preparation, and informative readout of physiological status. At the same time, it is also technically challenging to analyze due to its complex lipid composition affected by many factors, which can hamper th...
PMC10513930
Dynamic lipidome alterations associated with human health, disease and ageing
Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and cellular signalling. Here, we report >800 lipid species, many of which are associated with health-to-disease transitions in diabetes, ageing and inflammation, as well as cy...
PMC6691112
Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower motor neurons leading to muscle paralysis and death. While a link between dysregulated lipid metabolism and ALS has been proposed, lipidome alterations involved in disease progression are still understudied. Using a rodent model...
PMC9352691
"Comprehensive lipid and lipid-related gene investigations of host immune responses to characterize (...TRUNCATED)
"Despite remarkable success in the prevention and treatment of tuberculosis (TB), it remains one of (...TRUNCATED)
PMC11127996
Lipidome atlas of the adult human brain
"Lipids are the most abundant but poorly explored components of the human brain. Here, we present a (...TRUNCATED)
PMC6097988
"Phospholipidome of endothelial cells shows a different adaptation response upon oxidative, glycativ(...TRUNCATED)
"Endothelial dysfunction has been widely associated with oxidative stress, glucotoxicity and lipotox(...TRUNCATED)
PMC5050431
"LC-MS Based Sphingolipidomic Study on A2780 Human Ovarian Cancer Cell Line and its Taxol-resistant (...TRUNCATED)
"Drug resistance elicited by cancer cells continue to cause huge problems world-wide, for example, t(...TRUNCATED)
PMC9011034
"Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic (...TRUNCATED)
"Sinocyclocheilus represents a rare, freshwater teleost genus endemic to China that comprises the ri(...TRUNCATED)
PMC8342504
"Evaluation of two highly effective lipid-lowering therapies in subjects with acute myocardial infar(...TRUNCATED)
"For cardiovascular disease prevention, statins alone or combined with ezetimibe have been recommend(...TRUNCATED)
PMC9170690
"Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeosta(...TRUNCATED)
"We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and i(...TRUNCATED)
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