Summary description - The collection of this dataset named Fluorescence Skin Cancer (FLUO-SC) took about a year, resulting in 1,563 new samples of clinical images (CLI), captured under natural white light conditions, and 1,563 fluorescence (FLUO) samples. The endogenous fluorescence (label-free, autofluorescence) images were acquired using the LINCE device (MMO, São Carlos, Brazil); - The FLUO-SC dataset was collected along with the Dermatological and Surgical Assistance Program (in Portuguese: Programa de Assistência Dermatológica e Cirurgica - PAD) at the Federal University of Espírito Santo (UFES-Brazil), which is a nonprofit program that provides free skin lesion treatment, in particular, to low-income people who cannot afford private treatment. - The skin lesions are: Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), Actinic Keratosis (ACK), Seborrheic Keratosis (SEK), Melanoma (MEL), and Nevus (NEV). Resulting in three skin cancers (BCC, MEL, and SCC) and three skin disease (ACK, NEV, and SEK) - All BCC, SCC, and MEL are biopsy-proven. The remaining ones may have clinical diagnosis according to a consensus of a group of dermatologists. - The images present in the dataset may be have different sizes because they are collected using different smartphone devices. All images are available in .jpg format. Dataset Summary: Fluorescence Skin Cancer (FLUO-SC) The Fluorescence Skin Cancer (FLUO-SC) dataset was developed over approximately one year, resulting in 1,563 new samples of clinical images (CLI), captured under natural white light conditions, and 1,563 fluorescence (FLUO) samples. The fluorescence images represent endogenous, label-free autofluorescence acquired using the LINCE device (MMO, São Carlos, Brazil). The dataset collection was conducted as part of the Programa de Assistência Dermatológica e Cirúrgica (PAD), a nonprofit Dermatological and Surgical Assistance Program at the Federal University of Espírito Santo (UFES, Brazil). The PAD program focuses on providing free treatment for skin lesions, particularly benefiting low-income individuals who lack access to private healthcare. The dataset encompasses images of six distinct skin lesion categories: - Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), Melanoma (MEL) (biopsy-proven skin cancers); - Actinic Keratosis (ACK), Seborrheic Keratosis (SEK), and Nevus (NEV) (non-cancerous skin diseases, clinically diagnosed by consensus among dermatologists). The images in the dataset vary in dimensions due to the use of different smartphone devices during acquisition. All images are provided in .jpg format. Ethics statement The dataset was collected along with the Dermatological and Surgical Assistance Program (PAD) of the Federal University of Espírito Santo. The program is managed by the Department of Specialized Medicine and was approved by the university ethics committee (nº 500002/478) and the Brazilian government through Plataforma Brasil (nº 4.007.097), the Brazilian agency responsible for research involving human beings. In addition, all data is collected under patient consent and the patient’s privacy is completely preserved.