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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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270 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients in good health as confirmed by medical history
- not pregnant as demonstrated by negative urine pregnancy test
- completed their last term pregnancy at least 42 days prior to Screening and at least
one normal menstrual period since last pre... | An Open-Label Study to Compare the Bleeding Profile of Norelgestromin/Ethinyl Estradiol in an Extended Regimen to Norelgestromin/Ethinyl Estradiol Given in a Traditional Regimen | NCT00320580 | Contradiction |
3,404 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria
You may be eligible for this study if you:
- Are HIV-negative.
- Are between the ages of 18 and 60.
- Agree to use a barrier method of birth control (e.g., a condom) during the study.
Exclusion Criteria
You will not be eligible for this s... | A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood | NCT00000941 | Contradiction |
4,365 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Subjects should have normal eyes and use no ocular medications. They may have worn
contact lenses previously, provided their eyes are shown to be normal at the start of
the investigation. A normal eye is defined as having the following characteristics:
... | Clinical Performance of the OxyAqua Daily Disposable Silicone Hydrogel Soft Contact Lens | NCT03139201 | Entailment |
4,853 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Adrenal tumour with biochemical mild hypercortisolism defined as pathological
dexamethasone suppression test (cortisol > 50 nmol/L at 8.00 am after 1 mg
dexamethasone at 10 pm, plus one of the following criteria
- Low or suppressed adrenocorti... | Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome | NCT01246739 | Contradiction |
1,305 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Persons or legal guardian who have given their written informed consent
- Unclear molecular cause of the disease corresponding to the list of diseases selected
by the Solve-RD data interpretation force (principal investigator part of the team)
- Sus... | Diagnostic Research in Patients With Rare Diseases -Solving the Unsolved Rare Diseases | NCT04024774 | Contradiction |
2,451 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Biopsy proven skin sarcoidosis
- Assessable target skin lesions
Exclusion Criteria:
- Rapidly evolving sarcoidosis
- Patients necessitating a corticosteroid regimen of more than 15mg per day.
- Women not willing to undertake a co... | SARCOTHAL. Thalidomide in Skin Sarcoidosis | NCT00305552 | Entailment |
5,163 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Female and at least 45 years of age.
- Must have undergone the onset of spontaneous or surgical menopause more than 5 years
prior to entry. Spontaneous menopause is defined as 12 months of spontaneous
amenorrhea. Surgical menopause is defined as ≥ ... | A Study of Oral Recombinant Salmon Calcitonin (rsCT) to Prevent Postmenopausal Osteoporosis | NCT01292187 | Contradiction |
4,565 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women diagnosed of adenomyosis by pathology, transvaginal ultrasound or MRI.
Exclusion Criteria:
- Refusal to join the study
Female
| Cooperative Adenomyosis Network | NCT03230994 | Contradiction |
1,268 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Histological confirmation of thoracic malignancies including non-small cell lung
cancer (NSCLC), small lung cancer (SCLC), esophageal cancer, hypopharyngeal and
laryngeal cancers (for which esophagitis symptoms can be relieved by doxepin swallow),
... | Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy | NCT02062632 | Entailment |
1,333 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Have completed 24 months of BMN 111 treatment in Study 111-202.
- Parent(s) or guardian(s) are willing and able to provide written, signed informed
consent. Subjects under the age of majority are willing and able to provide written
assent (if requi... | A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH) | NCT02724228 | Contradiction |
5,459 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Historically lowest VWF:Ag and/or VWF:RCo and/or VWF:CB < 0.50 IU/ml and/or FVIII:C <
0.50 IU/ml
- All types of VWD
- All ages
Exclusion Criteria:
- Patient without consent to participate
No condition on gender to be admitted to... | Latin-American Von Willebrand Disease Registry | NCT04279717 | Entailment |
488 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | For participants with major depressive episode:
Inclusion criteria:
- female sex
- current diagnosis of a major depression episode
- minimum age of 18 years
- regular menstrual cycle.
Exclusion criteria:
- Pregnancy less than one year ago;
... | Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Study. | NCT04086316 | Contradiction |
3,898 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Painful osteoarthritis
- Hydarthrosis (synovial effusion)
Exclusion Criteria:
- large effusion
- severe pathologies
- anti-osteoarthritic treatments
No condition on gender to be admitted to the trial.
No healthy subjects accepted... | Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis | NCT00440661 | Entailment |
554 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- male factor infertility
- normal female hormonal profile
- normal uterine cavity
Exclusion Criteria:
- previous ICSI failure
- endometriosis
- azoospermia
Female
No healthy subjects accepted to join the trial.
Subject... | Intra-uterine Injection of Human Chorionic Gonadotrophin (hCG) Before Embryo Transfer | NCT01030393 | Contradiction |
3,422 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Woman aged 18 to 65, consultant in general medicine. (Any patient meeting the
inclusion criteria may choose to answer the questionnaire in the waiting room of
general practitioners selected by lot.)
Exclusion Criteria:
-
Female
Accepts Health... | Prevention of Cystitis. | NCT03744338 | Entailment |
1,273 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Age: 18-75
2. Patients have confirmed lung cancer by histopathological methods (fiber, bronchoscopy,
lung biopsy, open chest biopsy, pleural effusion exfoliated cells, sputum exfoliated
cells)
3. After clinical assessment, patients who ne... | Application of Diffusion Weighted MRI Versus CT in Evaluation of the Effect of Treating Lung Cancer | NCT02320617 | Entailment |
3,580 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- Adult (i.e., over 18 years old) men or women.
- Dry skin (i.e., Modified Kligman test >0)
- Accepts and signs the informed consent.
Exclusion Criteria
- Pregnant or breast-feeding women
- Subjects with a chronic disease that requ... | Effect of an Emollient Cream Containing 0.5% Cannabidiol and 1% Hemp Oil in the Hydration and Erythema of the Skin | NCT04045314 | Entailment |
1,717 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | - INCLUSION CRITERIA:
For Smokers:
1. males and females 18-64 years old
2. smoking 1-10 cigarettes or > 10 cigarettes per day for the past 6 months
For Nonsmokers:
1. males and females 18-64 years old
EXCLUSION CRITERIA:
For Smokers:
1. curr... | Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers | NCT01031121 | Entailment |
643 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Healthy males or non-pregnant, non-lactating healthy females
- Age 18 to 55 years of age (both inclusive)
- Must, in the opinion of the investigator, be in good health based upon medical
history, physical examination (including vital signs and ECGs)... | Bioequivalence Study Assessing Iron Sucrose or Venofer® in Healthy Adult Subjects | NCT04155814 | Contradiction |
4,186 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Azoospermia in at least 2 prior semen analysis.
- Diagnosis of Non-Obstructive Azoospermia or Diagnosis of Cryptozoospermia
Exclusion Criteria:
- Obstructive Azospermia
- Anatomical abnormalities in the genital tract,
- Cancer,
... | The Effects of Intratesticular PRP Injection in Men With Azoospermia or Cryptozoospermia | NCT04237779 | Contradiction |
5,682 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- overweight/obese adolescents in 8th grade
- BMI is over or equal to the 95th percentile (BMI>25 according to Cole's index)(height
and weight measured by the school nurse)
- school population
Exclusion criteria
- not have severe ... | Young, Fit and Happy. A Web-based Intervention to Prevent Obesity in Adolescents. | NCT01700309 | Contradiction |
15 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- 1. Voluntarily sign and date the study consent form(s) which have been approved by an
Institutional Review Board (IRB). Written consent must be obtained prior to the
initiation of any study procedures.
2. Male between 18 and 64 years of age, incl... | The Effects of Natesto For Treatment Of Hypogonadism On Maintenance Of Spermatogensis. | NCT04717362 | Contradiction |
5,298 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion criteria:
- Postmenopausal (PMO) women between 45 and 89 years of age.
- Bone mineral density T score of -2.5 or less at femoral neck, total hip or lumbar
spine OR
- Bone mineral density T score of -2.0 or less at femoral neck, total hip or lumbar
... | Efficacy Study of Zoledronic Acid and Teriparatide Combination Therapy in Women With Osteoporosis | NCT00439244 | Entailment |
2,742 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- informed consent
- age > 18 years
- inguinal hernia(primary, recurrence or bilateral)
- elective procedure
Exclusion Criteria:
- Scrotal hernia
- Prostatectomy, Pfannenstiehl-incision, pre-peritoneal surgery in histor... | LEVEL Trial: Correction of Inguinal Hernia, Endoscopic Versus Lichtenstein | NCT00788554 | Entailment |
756 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- 65 years old
- Diagnosed with knee osteoarthritis according to ACR diagnostic criteria
Exclusion Criteria:
Not having enough cooperation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at ... | Osteoarthritis, Balance, and Fear of Falling | NCT04660357 | Contradiction |
3,434 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Signed informed consent.
- Subjects between 40 and 65 years old. Diagnosis of type 2 diabetes mellitus with more
than 5 years of evolution of disease.
- Metformin (alone or in combination with sulfonylurea and / or insulin and / or
thia... | Study to Assess the Efficacy of Liraglutide in Patients With Type 2 Diabetes Mellitus | NCT02889510 | Entailment |
5,936 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Participants with grade N or M in the modified LA classification system confirmed by
endoscopy at initiation of the pre-observation period (VISIT 1).
2. Participants with repeated acid reflux symptoms (heartburn or regurgitation) for 2
days or more ... | Efficacy of TAK-438 Compared to Placebo in the Treatment of Non-Erosive Gastroesophageal Reflux Disease | NCT01474369 | Contradiction |
6,268 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Diagnosis of Covid-19 test positive; hospitalized subjects; both sexes; given informed
consent.
Exclusion Criteria:
- no exclusion criteriae
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Functional Exhaustion of T Cells in COVID19 Patients | NCT04470323 | Contradiction |
6,835 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients diagnosed with hemophilia A and B.
- With or without joint involvement clinically diagnosed, and with or without a previous
history of hemarthrosis joint load legs.
- In prophylactic regimen with FVIII / FIX concentrates .
- Res... | Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy | NCT02165462 | Entailment |
3,165 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Be male or female of any race, at least 18 years of age
- Have provided written informed consent
- Have a reported history of dry eye syndrome
- Have a history of use or desire to use eye drops for dry eye
Exclusion Criteria:
- H... | A Clinical Study to Assess the Safety and Efficacy of an Ophthalmic Solution (SkQ1) in the Treatment of Dry Eye Syndrome (DES) | NCT02121301 | Contradiction |
6,692 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Young Healthy Volunteers
- Participant is willing and able to give informed consent for participation in the
study.
- Male or Female, aged between 18 and 40 years old.
- Older Healthy Volunteers
- Particip... | Validation of Respiration Rate Algorithms | NCT01472133 | Contradiction |
6,188 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Confirmed COVID-19
Exclusion Criteria:
- N/A
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| A Clinical Trial for Hospitalized Patients With COVID-19 in Ceará: ResCOVID Study | NCT04649827 | Contradiction |
1,203 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- The participant is willing and able to give informed consent for participation in the
study.
- Adult male or female, aged 18 years or above.
- Diagnosed with a symptomatic pleural effusion requiring either diagnostic and/or
therapeutic ... | Using Ultrasound to Predict the Results of Draining Pleural Effusions | NCT01973985 | Entailment |
6,408 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Adults 18 years of age or older;
2. Diagnosis of SARS-CoV-2 infection confirmed by RT-PCR or antigen test no more than 5
days ago;
3. Onset of clinical signs and symptoms of COVID-19 no more than 5 days manifested as:
1. Presenting sud... | Clinical Trial for Assessment of Anti-SARS-CoV-2 Serum for Early Treatment of COVID-19 Cases | NCT04834089 | Entailment |
152 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Male aged 18 to 65 years, inclusive, at the time of providing informed consent to
participate in the study.
2. Hypogonadism defined as having 2 consecutive serum total T levels≤ 281 ng/dL based on
a blood sample, drawn at least 3 days apart, between... | Efficacy and Safety of Oral Testosterone Undecanoate in Hypogonadal Men | NCT03198728 | Entailment |
6,726 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients who are able to sign informed consent.
- Patients undergoing standard cardiac stress tests who are able to sign informed
consent.
- Patients with pulmonary disease who are being monitored in a routine manner who are
will ing to... | Ambulatory Measurements of Physiological Parameters | NCT01267513 | Contradiction |
3,223 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Patients with SGSp according to revised American-European criteria
- Patients 18 years of age or older
- Patients affiliated to the French social security care system.
Exclusion Criteria:
- Patients under measure of maintenance of justice.
... | Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome | NCT03157011 | Entailment |
6,484 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Healthy, male and non-pregnant female subjects, 18 years of age or older.
2. A diagnosis of papulopustular rosacea with ≥30 inflammatory facial lesions at
Baseline. Subjects must have no more than 2 nodular lesions, at Baseline.
3. Subjects with the p... | Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle | NCT02576860 | Entailment |
5,201 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Presents with severe osteoporosis based on the disease diagnostic criteria and upon
physician assessment
- Postmenopausal, nonpregnant, women older than 50 years of age, with previous fracture
history such as hip, spine, wrist, ribs, clavicle, hume... | Bone Marker Changes With Teriparatide/Postmenopausal Osteoporosis | NCT00532545 | Entailment |
2,653 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male <60yrs with primary inguinal hernia
Exclusion Criteria:
- Recurrent hernia
- Bilateral hernia
- Non-reducible/obstructed hernia
- Previous lower abdominal surgery/radiotherapy
Male
No healthy subjects accepted to join the tr... | Laparoscopic vs Open Hernia Mesh Repair for Inguinal Hernia | NCT00311935 | Entailment |
4,987 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Must be certified by a neurologist as having essential tremor or Parkinsonian tremor
that is insufficiently controlled by medication alone.
- Preference to receive radiation treatment for tremor treatment, rather than surgical
DBS implantation or s... | Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor | NCT01734122 | Entailment |
1,814 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age greater than or equal 18 years.
- Histologic or cytologic diagnosis of adenocarcinoma of stomach or gastric cardia
(Siewert Classification Type III)
- Preoperative Stage T3-4NxM0 by endoscopic ultrasound, CT of the abdomen/pelvis and
... | Neo-adjuvant Chemotherapy in Locally Advanced Gastric Cancer | NCT00414271 | Entailment |
4,380 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Patients attending routine genetic clinic/paediatric clinic appointments for diagnosis of
a multiple anomaly syndrome where distinctive facial features form part of their presenting
pattern.
OR:
- Biochemically or genetically confirmed diagnosis of inborn... | Evaluating Face-Recognition Technology in Syndrome Diagnosis | NCT04709965 | Entailment |
2,473 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
newly diagnosed sarcoidosis defined by presence of all of the following criteria:
1. Presence with clinical features of pulmonary (dyspnea, dry cough, chest pain, fever,
fatigue or crackles) or extra pulmonary organ (lymph nodes, liver, spleen, skin, eyes,
... | Efficacy of Antituberculous Therapy in Management of Sarcoidosis | NCT01245036 | Entailment |
604 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:The inclusion criterion was the presence at transvaginal ultrasound of
an extraovarian adnexal mass in women with a suspected ectopic pregnancy (amenorrhea,
bleeding and pain) with positive test for beta-hCG.
-
Exclusion Criteria:The exclusion criterion was non-tubal... | Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? | NCT01261026 | Entailment |
1,572 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Voluntary, written, informed consent to participate in the study
2. Agreement to comply with the protocol and study restrictions
3. Healthy females and males of age 25 to 60 years (inclusive)
4. Self-declared, suspected or medically diagnosed lactose in... | Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution | NCT03814668 | Contradiction |
2,484 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Age 40 years or older at enrollment
- Presenting visual acuity better than 20/100 in both eyes
- Spherical equivalent refractive error within the range of 4.0 and -6.0 diopters in
both eyes
Exclusion Criteria:
- Ocular surgery i... | The Detection of Glaucoma Using Pupillography | NCT01462526 | Entailment |
5,372 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Complaint of HMB, including women with fibroids
- Pre-menopausal
- Age 18 years and over
- Describing menstrual cycles every 21- 42 days
- Provide written informed consent prior to any study related procedures
- If of childbea... | Dexamethasone for Excessive Menstruation | NCT01769820 | Contradiction |
5,758 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Healthy
- Speaks and understands English or Danish
- 18-60 years
Exclusion Criteria:
- Pregnancy or lactation
- Drug addiction
- Previous or current dermatological, neurological, musculoskeletal or mental illnesses
... | Desensitization of Nociceptive Afferents by Application of Topical Capsaicin, Trans-cinnamaldehyde and L-menthol | NCT03132142 | Contradiction |
494 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- AMH (Anti-Müllerian hormone) > 6.28 pmol/L (Roche Elecsys assay)
- Female age 18 years to less than 40 years
- 1, 2 or 3 IVF/ICSI cycle with oocyte aspiration
- Regular menstrual cycle between 24 and 35 days
- BMI between 18 and 35
... | Study Comparing Outcomes Between Conventional IVF and a "Freeze-all"-Strategy in Assisted Reproductive Technology | NCT02746562 | Contradiction |
2,758 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
Clinical diagnosis of symptomatic inguinal hernia Age 18-80
Exclusion Criteria:
Large scrotal hernia Bilateral hernia Symptom-free hernia Inguinal pain without clinical
evidence of hernia Asa class≥3
No condition on gender to be admitted to the trial.
No healthy su... | Postoperative Pain After Extraperitoneal Endoscopic Technique (TEP) vs. Lichtenstein Hernioplasty in Inguinal Hernia Repair | NCT03566433 | Entailment |
2,206 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion criteria:
- 3 or more gout flares within last year
- Contraindication, intolerance or lack of efficacy for NSAIDs and/or colchicine
- Body mass index of less than or equal to 45 kg/m2
Exclusion criteria:
- Use of the following therapies (within varying ... | Safety and Efficacy of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients | NCT01356602 | Contradiction |
1,115 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Patients aged 9-21 years
- Referred to the neurology POTS and Syncope clinic at Nationwide Children's Hospital
for clinical tilt table testing
- Has prior diagnosis or signs/symptoms of POTS (with or without syncope) or syncope
(without... | EEG Characteristics in Youth POTS and/or Syncope | NCT02167412 | Entailment |
279 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Unexplained infertility ( 1ry & 2ndry infertility) : *
- Normal hormonal profile of infertile woman.
- Normal hystrosalpingogram.
- Normal laparoscopy.
- Normal investigation of the cervical factor
- F... | Effect of Endometrial Injury in Couples With Unexplained Infertility | NCT03398993 | Contradiction |
233 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Female with age between 18-40 years.
- Regular menstrual cycles
- Female diagnosed by ultrasound with unilateral ovarian endometrioma ≥4cm and ≤6cm.
Exclusion Criteria:
- Hormone, Gonadotropin-releasing hormone analogues or contraceptive the... | Assessment of Ovarian Reserve After Laparoscopic Cystectomy Versus Aspiration/Electrocoagulation in the Treatment of Ovarian Endometrioma | NCT04151173 | Contradiction |
5,590 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Young girls with turner syndrome proved by karyotype
- Growth hormone secretion confirmed with ornithin stimulation test
- Normal glucidic metabolism confirmed by assessment of HbA1c
- None associated severe pathology which could have impact on growt... | Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years | NCT01066052 | Contradiction |
3,847 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Age: greater than 18 years
- Weight: less than 300 lbs.
- Diagnosis: osteoarthritis
- Type of Surgery: unilateral knee replacement
Exclusion Criteria:
- No pacemaker or defibrillator.
- No infection of the affected kn... | Use of Pulsed Electromagnetic Fields for Postoperative Knee Pain | NCT01415856 | Entailment |
6,767 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male ≥18 years of age
- Severe or moderately severe hemophilia A (FVIII activity ≤ 2 IU/dL) as evidenced by
- medical history
- Received FVIII prophylactic or on-demand replacement therapy for ≥ 150 accumulated
- days (exposure days)
... | ASC618 Gene Therapy in Hemophilia A Patients | NCT04676048 | Entailment |
5,440 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- type 1 vWD patients
- healthy subjects with no known problem with bleeding or bruising were also recruited
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
| Evaluation of Bleeding Score in Egyptian Patients With vWD Type I and Correlate it With Laboratory Parameters | NCT03915873 | Entailment |
1,846 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Pathological diagnosis of gastric adenocarcinoma
- Radical operation and adjuvant chemotherapy endurable
- Informed consent approved
Exclusion Criteria:
- Age <18 or >75 years old
- Pregnancy or lactating woman
- Any ... | The Predictive Value of Complement C3 in Patients With Advanced Gastric Cancer | NCT02425930 | Entailment |
4,536 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Age: 35-49 years old.
- Normal gynecologic and breast examination
- Women who have sterilization or husband is sterilized or accepts to use a suitable
barrier contraception during the duration of the study.
- Heavy periods (were assessed... | Effects of Tranexemic Acid Versus Norethisterone Acetate on Endometrial Vasculature . | NCT04290013 | Contradiction |
2,772 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Age 30-75 years
- Men
- Primary inguinal hernia
- ASA I-III
Exclusion Criteria:
- > 75 years
- Females
- ASA IV
- Previous ipsi-lateral hernia surgery
- Drug or alchol abuse
... | PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results | NCT00580177 | Entailment |
6,278 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Age from 18 to 65 years of age, inclusive, at the time of signing the informed
consent.
2. Willing and able to provide informed consent.
3. Women of reproductive potential must be using a highly effective method of
contraception for at le... | COVID-19 Treatment in South Africa | NCT04532931 | Entailment |
2,184 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Subjects with gout and at least one tophi.
Exclusion Criteria:
- Unable to undergo MRI.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years | Magnetic Resonance Imaging in Subjects With Gouty Tophi | NCT00174954 | Contradiction |
3,474 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- On stable doses of atorvastatin (40 mg daily) for 45 days prior to Day 1.
- BMI 18.5 to 40 kg/m2 inclusive, and body weight equal or lower than 150 kg.
Exclusion Criteria:
- History of a cardiovascular event (e.g., MI ) during the past year.
... | Pharmacokinetic And Pharmacodynamic Study Of A Single-Dose Of PF-04950615 (RN316) In Combination With Atorvastatin | NCT01163851 | Entailment |
1,849 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients must have histologic and radiographic proof of localized high-risk soft
tissue sarcoma (STS) required prior to registration.
- For the purpose of this study, high risk STS is defined by at least two of the
following risk factors:
... | Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas | NCT00881595 | Entailment |
3,663 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Patients admitted to a Korean Medicine hospital for low back pain with or without
radiculopathy
- Age between 18 and 69
- NRS score of >6 on the day of the intervention
- Voluntary participation with written consent given to study consen... | Immediate Pain Relieving Effects of Sinbaro-3 for Low Back Pain | NCT02196129 | Contradiction |
3,593 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
1. Refractory menorrhagia with no definable organic cause
2. Female subject from age 25 to 50 years
3. Uterine sound measurement of 6.0cm to 10.0cm (external os to internal fundus)
4. One of the following criteria:
A. Documented history of me... | A Single Arm Clinical Study of the Safety and Efficacy of the AURORA™ Endometrial Ablation System | NCT02023801 | Contradiction |
2,642 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Age 18 or older with unilateral or bilateral inguinal herna for laparoscopic repair
- American Society of Anesthesiology (ASA) Class I and II
Exclusion Criteria:
- Conversion from laparoscopic to open surgery
- History of Chronic pain or ong... | Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair | NCT02055053 | Entailment |
4,042 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Any gender and age from 45 to 70 years
- Symptomatic osteoarthritis (OA) of the knee with mild joint discomfort for at least 6
months prior to enrollment, following ACR criteria with history and physical
examination(44). Subjects diagnosed with bil... | Clinical Trial to Evaluate the Effects of a Nutraceutical in Patients Affected by Knee Osteoarthritis | NCT03612986 | Entailment |
2,701 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- planned laparoscopic inguinal or femoral herniorrhaphy
- ASA class I-II
- speak and read danish
Exclusion Criteria:
- converting to open operation
- low compliance (dementia, psychiatric disorder)
- use of morphine or... | Pain and Convalescence After Laparoscopic Groin Hernia Repair | NCT00962338 | Entailment |
2,866 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- male or female
- age > 30 years
- definite or probable ALS according to the El Escorial criteria, bulbar or spinal form,
ALS diagnosis < 1 year and treatment by riluzole.
Exclusion Criteria:
- family history of ALS,
-... | Mitochondrial Functions and Oxidative Stress in ALS Patients | NCT00331812 | Entailment |
1,871 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age from over 18 to under 75 years
- Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
poorly differentiated) confirmed pathologically by endoscopic biopsy
- cT2-4a(clinical stage tumor), N-/+, M0 at preoperative eva... | Clinical Outcomes of Robotic Versus Laparoscopic Assisted Radical Gastrectomy for Advanced Siewert II/III AEG | NCT04153058 | Entailment |
5,148 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. Women or adult men (>18 years of age) with various medical diseases requiring
long-term prednisolone treatment. Pre-menopausal women should have no plan for
pregnancy within 2 years of study entry and agree to practice contraception during
this 2-... | Denosumab in Current Users of Bisphosphonates for Glucocorticoid-induced Osteoporosis | NCT01465568 | Contradiction |
4,700 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Age 18-50 years, inclusive
- General good health (by volunteer history and per investigator discretion)
- History of and currently regular menstrual cycles
- Willing to abstain from the use of vaginal products, other than the TFV gel and her
... | In Vivo Drug Interaction Pharmacokinetic Study of Tenofovir 1% Gel and Three Commonly Used Vaginal Products | NCT01813162 | Entailment |
333 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
Increased levels of serum β-hCG and ultrasonography findings. The criteria for diagnosis by
ultrasonography was the presence of the following: (1) an empty uterine cavity and
endocervical canal; (2) detection of the placenta and/or a gestational sac embedded in the
h... | Outcome After MTX & Transvaginal Surgery or UAE & Uterine Curettage in Patients With Cesarean Scar Pregnancy | NCT03218059 | Contradiction |
1,859 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion criteria:
1. histologically or cytologically confirmed diagnosis of advanced gastric adenocarcinoma
2. Has a PTEN-deficient tumor as documented from archival or fresh (from biopsy) tumor
tissue or has shown genomic alterations in PI3K pathway genes (PIK3CB, PI3KR1, PTEN,
... | PI3Kβ Selective Inhibitor With Paclitaxel, Advanced Gastric Adenocarcinoma | NCT02615730 | Entailment |
5,339 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Age 18-45 years, inclusive
- General good health (by volunteer history and per investigator discretion) without any
clinically significant systemic disease (including, but not limited to significant
liver disease/hepatitis, gastrointestinal disease... | Phase I One-month Safety, PK, PD, and Acceptability Study of IVR Releasing TFV and LNG or TFV Alone | NCT02235662 | Contradiction |
2,430 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Patient referred to bronchoscopy for tissue diagnosis of discrete enlarged (≥10mm
short axis diameter) mediastinal/hilar lymph nodes on CT scan that can be sampled by
E(B)US-NA.
Exclusion Criteria:
- Abnormal chest X-ray showing hilar/medi... | Linear Endosonography for the Assessment of Sarcoidosis Stage O | NCT01383226 | Contradiction |
6,117 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Recipient Inclusion Criteria:
- Patients with severe COVID-19 will be considered for randomization and will be transfused
convalescent plasma within 3 days of symptom onset (Severe COVID-19) Severe COVID -19
defined by WHO Interim Guidance and the Guideline of Diagnosis and Treatment of COVID-1... | Efficacy of Convalescent Plasma Therapy in Patients With COVID-19 | NCT04425915 | Contradiction |
1,647 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Age 18-45 years, inclusive, of both genders
- Negative pregnancy test for females who are not s/p hysterectomy with oophorectomy
- No history of episodic wheezing, chest tightness, or shortness of breath consistent
with asthma, or physician-diagnose... | Woodsmoke Particulate + Hypertonic Saline | NCT03851406 | Entailment |
3,157 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Subject must have dry eye.
2. Age: 18 years and older.
3. Males or females
4. Up to grade 3 conjunctival staining.
5. Score of no more than 4 on the Subjective Evaluation of Symptoms of Dryness (SESOD) at
screening.
6.... | Evaluation of Blink Tears and Systane Concomitant With Restasis for the Treatment of Dry Eye Symptoms | NCT00565669 | Contradiction |
1,184 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- The subject must meet all of the following inclusion criteria to participate in this
study.
1. Evidence of pleural disease on chest radiograph or bedside ultrasound or Computed
Tomography regardless of underlying aetiology
... | Pleural Disease: Phenotypes, Diagnostic Yield and Outcomes | NCT03922841 | Entailment |
1,226 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- age 18 or older
- smokes at least five cigarettes daily for at least past 12 months
- wants to quit cigarette smoking in the next 30 days
- if concurrently using any other nicotine or tobacco products, wants to quit using them
within the... | Trial of An Innovative Smartphone Intervention for Smoking Cessation | NCT02724462 | Entailment |
2,830 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Clinical signs of weakness attributed to ALS.
- Familial ALS with a documented SOD1 gene mutation.
- Age 18 years or older.
- Capable of providing informed consent and willing to comply with trial procedures and
time commitments.
... | Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations | NCT01041222 | Entailment |
1,131 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Adult patients (>= 16 years) with a complaint of TLoC
Exclusion Criteria:
- Patients needing immediate treatment, with trauma related or drug or alcohol related
TLoC were excluded, as well as patient with persistent altered level of consciousness,
... | NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness | NCT01498471 | Entailment |
6,390 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients presenting with clinical suspicion of COVID-19 infection, as per UHN case
definition at the time of presentation
- Age >18 years
- Ability to provide verbal informed consent
Exclusion Criteria:
- Patients who are not su... | Enhanced Triage for COVID-19 | NCT04750369 | Entailment |
4,131 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
General and Demographic Criteria
1. Age of 18 to 40 years
2. Access to a participating HVTN CRS and willingness to be followed for the planned
duration of the study
3. Ability and willingness to provide informed consent
4. Assessment ... | Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine | NCT03284710 | Contradiction |
1,869 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age 18 or over
- Histological diagnosis of recurrent or metastatic gastric cancer
- Immunohistochemistry (IHC 0 or 1+) or FISH negative (if IHQ 2+) for HER2 on tissue
biopsy, according to institutional routine
- Candidates to initiate fi... | Trastuzumab to Patients With Advanced Gastric Cancer With HER2 Positive Expression in CTC | NCT04168931 | Entailment |
3,558 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | - INCLUSION CRITERIA:
Patients:
Age greater than or equal to 18 years
Diagnosis of EM - an expanding annular lesion, at least 5 cm in diameter on a person with a
history of exposure to the disease.
Exposure is defined as having been (less than or equal to 30 days before onse... | Analysis of Lyme Disease Lesions | NCT00132327 | Contradiction |
1,422 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Willing to participate
- Having swallowing problems
Exclusion Criteria:
- Being under the age of 20 years, and above the age of 60 years
- Not willing to participate
- No swallowing problems
Male
No healthy subjects accepted to j... | The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals | NCT03907566 | Contradiction |
1,070 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Over 18 years.
- Diagnosis of neurally mediated syncope with a tilting table test (Tilt test) that
demonstrates a mixed (type 1) or cardioinhibitory response (Type 2A and 2B).
- Negative impact on work and social life.
- Non-respondent t... | Pacemaker Effect With Closed Loop Sensor in Neuromodulated Syncope Refractory to Medical Therapy | NCT03876652 | Contradiction |
6,467 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Male or non-pregnant, non-lactating female, 18 years of age or older.
2. Signed informed consent form that meets all criteria of current Food and Drug
Administration regulations.
3. Females of childbearing potential must not be pregnant or lactating.
... | An Evaluation of the Reduction in Erythema in Adult Patients With Moderate to Severe Persistent Facial Erythema Associated With Rosacea | NCT03352323 | Entailment |
349 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women between the ages of 18 and 38 inclusive
- Women with BMI up to 40
- Women able to freely give consent electronically, given COVID. For the purposes of
this study, this is defined as women who speak native or fluent English; and have a
... | Sonograms Enable Looking Forward - Home Examinations Led by Providers Validation Study | NCT04687189 | Contradiction |
933 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Age =>30 years
- Knee pain which appeared without any apparent cause, exacerbated by exertion and
subsided by rest.
- Presence of limited morning stiffness
- No history of infection, inflammation or trauma to rule out secondary OA
... | An Attempt to Find Out Root Cause of a Pain Producing Knee Disease | NCT04496440 | Entailment |
4,199 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria Healthy Volunteers:
1. Healthy male volunteers between 18 and 50 years of age inclusive.
2. Able to communicate with site personnel and to understand and voluntarily sign the
Informed Consent Form.
3. Able and willing to comply with the Protocol, includin... | Inhaled Vancomycin Tolerability, Safety and Pharmacokinetics | NCT01537666 | Contradiction |
1,483 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- All patients who presented to GI Motility Lab at IU University Hospital for esophageal
manometry-impedance and/or EndoFLIP
Exclusion Criteria:
- Age <18 yrs old
- Unable to communicate verbally with the staff
No condition on gender to be ad... | Esophageal Impedance and Manometry Measurements and Dysphagia Symptom Scoring | NCT04503785 | Entailment |
2,862 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
Medical Subjects:
- Be able to give consent themselves or via a legally authorized representative.
- Diagnosed with a neuromuscular disease and have limited ability to communicate.
- Be able to see visual cues such as targets or letters presented on the s... | EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) | NCT00718458 | Entailment |
4,050 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Referred to Sahlgrenska University hospital
- Primary osteoarthritis in the hip or knee
- Understanding and speaking Swedish
Exclusion Criteria:
- Prior assessment by and referral from an orthopedic surgeon for the current problem
... | PT-led Triage for Patients With Hip o Knee Osteoarthritis | NCT04665908 | Entailment |
1,531 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Women aged 18-50 years, inclusive
2. General good health, by volunteer history and per investigator judgment
3. History of regular menstrual cycles of 24-35 days (inclusive), by volunteer report
4. History of Pap tests and follow-up consistent with stan... | Safety and Acceptability Study of a Non-Hormonal Ring | NCT03598088 | Contradiction |
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