# REFUGE2 Dataset for PixelGen Medical Image Generation # Optic disc/cup segmentation: 1200 RGB fundus images with 3-class masks # Mask values: 0=background, 128=optic cup, 255=optic disc import os import torch import random import numpy as np from torch.utils.data import Dataset from PIL import Image import torchvision.transforms as transforms import torchvision.transforms.functional as TF from torchvision.transforms import Normalize class REFUGE2Dataset(Dataset): """ REFUGE2 dataset for mask-conditional image generation. Data format: - Images: RGB fundus photographs (varying sizes ~1600-2100px) - Masks: 3-class segmentation (0=background, 128=optic cup, 255=optic disc) - 400 images per split (train/val/test) - Mask files: train/test=.bmp, val=.png Returns format compatible with PixelGen: - normalized_image: [3, H, W] in range [-1, 1] - label: class label (0 for all) - metadata: dict with 'raw_image', 'mask', 'class' """ def __init__(self, data_root, resolution=256, splits=('train', 'val'), augment=True, seed=42, max_samples=None, random_flip=True, val_ratio=0.0): super().__init__() self.data_root = data_root self.resolution = resolution self.augment = augment self.random_flip = random_flip # Collect files from specified splits all_pairs = [] for split in splits: img_dir = os.path.join(data_root, split, 'images') mask_dir = os.path.join(data_root, split, 'mask') img_files = sorted([f for f in os.listdir(img_dir) if f.endswith(('.jpg', '.png', '.jpeg'))]) for img_f in img_files: img_path = os.path.join(img_dir, img_f) # Mask may have different extension (.bmp or .png) base_name = os.path.splitext(img_f)[0] mask_path = None for ext in ['.bmp', '.png', '.jpg']: candidate = os.path.join(mask_dir, base_name + ext) if os.path.exists(candidate): mask_path = candidate break if mask_path is not None: all_pairs.append((img_path, mask_path)) # Optional: hold out a portion for validation if val_ratio > 0: random.seed(seed) random.shuffle(all_pairs) split_idx = int(len(all_pairs) * (1 - val_ratio)) self.pairs = all_pairs[:split_idx] else: self.pairs = all_pairs # Limit samples if specified if max_samples is not None and max_samples < len(self.pairs): random.seed(seed) self.pairs = random.sample(self.pairs, max_samples) # Normalization for images ([-1, 1] range) self.normalize = Normalize(mean=[0.5, 0.5, 0.5], std=[0.5, 0.5, 0.5]) print(f"[REFUGE2Dataset] splits={splits}: {len(self.pairs)} image pairs") def __len__(self): return len(self.pairs) def _load_and_process(self, idx): """Load and process a single sample.""" img_path, mask_path = self.pairs[idx] image = Image.open(img_path).convert('RGB') mask = Image.open(mask_path).convert('L') # Resize to target size (square) image = TF.resize(image, (self.resolution, self.resolution), interpolation=transforms.InterpolationMode.BILINEAR) mask = TF.resize(mask, (self.resolution, self.resolution), interpolation=transforms.InterpolationMode.NEAREST) # Data augmentation if self.augment: if self.random_flip and random.random() > 0.5: image = TF.hflip(image) mask = TF.hflip(mask) if self.random_flip and random.random() > 0.5: image = TF.vflip(image) mask = TF.vflip(mask) # Random color jitter for image only if random.random() > 0.5: brightness_factor = random.uniform(0.85, 1.15) image = TF.adjust_brightness(image, brightness_factor) contrast_factor = random.uniform(0.85, 1.15) image = TF.adjust_contrast(image, contrast_factor) saturation_factor = random.uniform(0.85, 1.15) image = TF.adjust_saturation(image, saturation_factor) return image, mask def __getitem__(self, idx): max_retries = 10 for retry in range(max_retries): try: actual_idx = (idx + retry) % len(self.pairs) image, mask = self._load_and_process(actual_idx) break except Exception as e: if retry == max_retries - 1: raise RuntimeError(f"Failed to load image after {max_retries} retries: {e}") continue raw_image = TF.to_tensor(image) # [3, H, W], range [0, 1] normalized_image = self.normalize(raw_image) # Normalize mask: 0->0.0, 128->0.5, 255->1.0 mask_tensor = TF.to_tensor(mask) # [1, H, W], range [0, 1] label = 0 metadata = { "raw_image": raw_image, "mask": mask_tensor, "class": label, } return normalized_image, label, metadata class REFUGE2ValDataset(Dataset): """Validation subset from REFUGE2 (held-out from training splits).""" def __init__(self, data_root, resolution=256, splits=('train', 'val'), val_ratio=0.1, seed=42): super().__init__() self.resolution = resolution self.normalize = Normalize(mean=[0.5, 0.5, 0.5], std=[0.5, 0.5, 0.5]) all_pairs = [] for split in splits: img_dir = os.path.join(data_root, split, 'images') mask_dir = os.path.join(data_root, split, 'mask') img_files = sorted([f for f in os.listdir(img_dir) if f.endswith(('.jpg', '.png', '.jpeg'))]) for img_f in img_files: base_name = os.path.splitext(img_f)[0] img_path = os.path.join(img_dir, img_f) mask_path = None for ext in ['.bmp', '.png', '.jpg']: candidate = os.path.join(mask_dir, base_name + ext) if os.path.exists(candidate): mask_path = candidate break if mask_path is not None: all_pairs.append((img_path, mask_path)) random.seed(seed) random.shuffle(all_pairs) split_idx = int(len(all_pairs) * (1 - val_ratio)) self.pairs = all_pairs[split_idx:] print(f"[REFUGE2ValDataset] {len(self.pairs)} val samples") def __len__(self): return len(self.pairs) def __getitem__(self, idx): img_path, mask_path = self.pairs[idx] image = Image.open(img_path).convert('RGB') mask = Image.open(mask_path).convert('L') image = TF.resize(image, (self.resolution, self.resolution), interpolation=transforms.InterpolationMode.BILINEAR) mask = TF.resize(mask, (self.resolution, self.resolution), interpolation=transforms.InterpolationMode.NEAREST) raw_image = TF.to_tensor(image) normalized_image = self.normalize(raw_image) mask_tensor = TF.to_tensor(mask) label = 0 metadata = { "raw_image": raw_image, "mask": mask_tensor, "class": label, } return normalized_image, label, metadata class REFUGE2RandnDataset(Dataset): """Random noise dataset for evaluation/prediction with REFUGE2 masks.""" def __init__(self, data_root, resolution=256, max_num_instances=1000, noise_scale=1.0, seed=42, splits=('train', 'val', 'test')): super().__init__() self.resolution = resolution self.noise_scale = noise_scale # Collect all mask paths all_masks = [] for split in splits: mask_dir = os.path.join(data_root, split, 'mask') if not os.path.exists(mask_dir): continue mask_files = sorted([f for f in os.listdir(mask_dir) if f.endswith(('.bmp', '.png', '.jpg'))]) for mf in mask_files: all_masks.append(os.path.join(mask_dir, mf)) random.seed(seed) if max_num_instances <= len(all_masks): self.mask_paths = random.sample(all_masks, max_num_instances) else: self.mask_paths = all_masks * (max_num_instances // len(all_masks) + 1) self.mask_paths = self.mask_paths[:max_num_instances] print(f"[REFUGE2RandnDataset] {len(self.mask_paths)} samples for generation") def __len__(self): return len(self.mask_paths) def __getitem__(self, idx): xT = self.noise_scale * torch.randn(3, self.resolution, self.resolution) mask = Image.open(self.mask_paths[idx]).convert('L') mask = TF.resize(mask, (self.resolution, self.resolution), interpolation=transforms.InterpolationMode.NEAREST) mask_tensor = TF.to_tensor(mask) label = 0 metadata = { "mask": mask_tensor, "class": label, } return xT, label, metadata