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['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'can', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells can be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'can', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells can be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'could', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells could be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'could', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells could be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'could', 'have', 'been', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells could have been mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'could', 'have', 'been', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells could have been significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
9
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'has', 'been', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells has been mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'has', 'been', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells has been significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'has', 'the', 'ability', 'to', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells has the ability to be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
10
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'has', 'the', 'ability', 'to', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells has the ability to be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
11
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'has', 'the', 'probability', 'of', 'being', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells has the probability of being mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
10
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'has', 'the', 'probability', 'of', 'being', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells has the probability of being significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
11
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'is', 'able', 'to', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells is able to be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
9
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'is', 'able', 'to', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells is able to be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
10
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'is', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells is mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
6
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'is', 'observed', 'to', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells is observed to be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
9
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'is', 'observed', 'to', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells is observed to be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
10
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'is', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells is significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'may', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells may be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'may', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells may be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'may', 'have', 'been', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells may have been mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'may', 'have', 'been', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells may have been significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
9
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'might', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells might be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'might', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells might be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'might', 'have', 'been', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells might have been mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'might', 'have', 'been', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells might have been significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
9
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'was', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells was mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
6
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'was', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells was significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'will', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells will be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'will', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells will be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'would', 'be', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells would be mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
7
mutate
['B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'B-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'I-Mutate.01-ARG-3', 'O']
['alpha-chain', 'cdna', 'in', 'cos-1', 'cells', 'would', 'be', 'significantly', 'mutated', 'by', 'transient', 'expression', 'of', 'the', 'exon', '8', 'resulted', 'in', 'deficiency', 'of', 'enzymatic', 'activity', '.']
alpha-chain cdna in cos-1 cells would be significantly mutated by transient expression of the exon 8 resulted in deficiency of enzymatic activity.
8
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'being', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences being mutated support this conclusion.
12
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences mutated support this conclusion.
11
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'that', 'are', 'able', 'to', 'be', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences that are able to be mutated support this conclusion.
16
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'that', 'are', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences that are mutated support this conclusion.
13
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'that', 'can', 'be', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences that can be mutated support this conclusion.
14
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'that', 'have', 'been', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences that have been mutated support this conclusion.
14
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'that', 'may', 'have', 'been', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences that may have been mutated support this conclusion.
15
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'that', 'were', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences that were mutated support this conclusion.
13
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'which', 'are', 'able', 'to', 'be', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences which are able to be mutated support this conclusion.
16
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'which', 'are', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences which are mutated support this conclusion.
13
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'which', 'can', 'be', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences which can be mutated support this conclusion.
14
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'which', 'have', 'been', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences which have been mutated support this conclusion.
14
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'which', 'may', 'have', 'been', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences which may have been mutated support this conclusion.
15
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'dam', 'target', 'sequences', 'which', 'were', 'mutated', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with dam target sequences which were mutated support this conclusion.
13
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'I-Mutate.01-ARG-1', 'O', 'O', 'O', 'O']
['analyses', 'of', 'transcription', 'in', 'vivo', 'of', 'agn-lacz', 'with', 'mutated', 'dam', 'target', 'sequences', 'support', 'this', 'conclusion', '.']
analyses of transcription in vivo of agn-lacz with mutated dam target sequences support this conclusion.
8
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'mutated', 'p53', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with mutated p53, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'can', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that can be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'can', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that can be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'could', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that could be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'could', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that could be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'has', 'been', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that has been mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'has', 'been', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that has been remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'has', 'the', 'ability', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that has the ability to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'has', 'the', 'ability', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that has the ability to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'able', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is able to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'able', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is able to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'believed', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is believed to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'believed', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is believed to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'observed', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is observed to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'observed', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is observed to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'is', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that is remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'may', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that may be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'may', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that may be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'might', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that might be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'might', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that might be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'might', 'have', 'been', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that might have been mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'might', 'have', 'been', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that might have been remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'will', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that will be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'will', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that will be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'would', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that would be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'that', 'would', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 that would be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'can', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which can be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'can', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which can be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'could', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which could be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'could', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which could be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'has', 'been', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which has been mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'has', 'been', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which has been remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'has', 'the', 'ability', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which has the ability to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'has', 'the', 'ability', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which has the ability to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'able', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is able to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'able', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is able to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'believed', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is believed to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'believed', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is believed to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'observed', 'to', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is observed to be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'observed', 'to', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is observed to be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'is', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which is remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'might', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which might be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'might', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which might be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'might', 'have', 'been', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which might have been mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'might', 'have', 'been', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which might have been remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'will', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which will be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'will', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which will be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'would', 'be', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which would be mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['cotransfections', 'with', 'plasmids', 'expressing', 'wt-1', ',', 'wtar', '(', 'a', 'mutated', 'form', 'of', 'wt-1', ')', ',', 'p53', ',', 'and', 'a', 'mutated', 'form', 'of', 'p53', 'revealed', 'a', 'complex', 'pattern', 'of', 'regulation', 'with', 'a', '3-fold', 'induction', 'with', 'wt-1', ',', 'a', '7-fold', 'induction', 'with', 'p53', 'which', 'would', 'be', 'remarkably', 'mutated', ',', 'and', 'a', '4-fold', 'repression', 'with', 'wild-type', 'p53', '.']
cotransfections with plasmids expressing wt-1, wtar (a mutated form of wt-1), p53, and a mutated form of p53 revealed a complex pattern of regulation with a 3-fold induction with wt-1, a 7-fold induction with p53 which would be remarkably mutated, and a 4-fold repression with wild-type p53.
9
mutate
['O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['for', 'example', ',', 'mutating', 'the', 'c-terminal', 'map', 'kinase', 'sites', '(', 't235', 'and', 't239', ')', 'essentially', 'leads', 'to', 'abolished', 'egf-stimulated', 'increase', 'in', 'phosphorylation', 'and', 'prevented', 'egf-induced', 'mobility', 'shift', '(', 'figure', '5c', ',', 'lanes', '7', 'and', '8', ')', '.']
for example, mutating the c-terminal map kinase sites (t235 and t239) essentially leads to abolished egf-stimulated increase in phosphorylation and prevented egf-induced mobility shift (figure 5c, lanes 7 and 8).
3
mutate
['O', 'O', 'O', 'O', 'B-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'I-Mutate.01-ARG-0', 'O', 'O', 'O', 'O', 'B-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'I-Mutate.01-ARG-2', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O', 'O']
['for', 'example', ',', 'mutating', 'the', 'c-terminal', 'map', 'kinase', 'sites', '(', 't235', 'and', 't239', ')', 'has', 'essentially', 'led', 'to', 'abolished', 'egf-stimulated', 'increase', 'in', 'phosphorylation', 'and', 'prevented', 'egf-induced', 'mobility', 'shift', '(', 'figure', '5c', ',', 'lanes', '7', 'and', '8', ')', '.']
for example, mutating the c-terminal map kinase sites (t235 and t239) has essentially led to abolished egf-stimulated increase in phosphorylation and prevented egf-induced mobility shift (figure 5c, lanes 7 and 8).
3
mutate