prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Activation of MYMK in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
MYMK
|
response to virus
|
Hepatoma Cell Line
|
Gene: MYMK (myomaker, myoblast fusion factor)
Type: protein-coding
Summary: Involved in myoblast fusion. Located in plasma membrane. Implicated in Carey-Fineman-Ziter syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: muscle organ development, myoblast fusion, myoblast fusion involved in skeletal muscle regeneration, plasma membrane fusion, positive regulation of skeletal muscle hypertrophy, skeletal muscle tissue regeneration; CC: Golgi apparatus, Golgi membrane, membrane, plasma membrane
Pathways:
UniProt: A6NI61
Entrez ID: 389827
|
Does Knockout of RPL9 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
RPL9
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: RPL9 (ribosomal protein L9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, focal adhesion, membrane, nucleus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P32969
Entrez ID: 6133
|
Does Knockout of GKN2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
GKN2
|
cell proliferation
|
Cancer Cell Line
|
Gene: GKN2 (gastrokine 2)
Type: protein-coding
Summary: The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: NLRP3 inflammasome complex assembly, gene expression, inflammatory response, neutrophil activation involved in immune response, regulation of cell population proliferation, response to bacterium, response to cortisol, response to stress, response to wounding; CC: basal part of cell, extracellular region, extracellular space
Pathways:
UniProt: Q86XP6
Entrez ID: 200504
|
Does Knockout of RPS7 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RPS7
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RPS7 (ribosomal protein S7)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, negative regulation of ubiquitin protein ligase activity, negative regulation of ubiquitin-dependent protein catabolic process, neural crest cell differentiation, neural tube closure, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, protein stabilization, rRNA processing, ribosomal small subunit biogenesis, translation; MF: RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding, protein kinase binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62081
Entrez ID: 6201
|
Does Knockout of TSSK2 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
TSSK2
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: TSSK2 (testis specific serine kinase 2)
Type: protein-coding
Summary: TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell differentiation, protein autophosphorylation, protein phosphorylation, spermatid development, spermatogenesis; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: acrosomal vesicle, centriole, cytoplasm, cytoskeleton, nucleus
Pathways: 22q11.2 copy number variation syndrome
UniProt: Q96PF2
Entrez ID: 23617
|
Does Knockout of GRWD1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
GRWD1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: GRWD1 (glutamate rich WD repeat containing 1)
Type: protein-coding
Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: DNA replication, nucleosome assembly, nucleosome disassembly, ribosome biogenesis; MF: DNA replication origin binding, RNA binding, chromatin binding, histone binding, protein binding; CC: chromosome, cytosol, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9BQ67
Entrez ID: 83743
|
Does Knockout of NUDC in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
NUDC
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: NUDC (nuclear distribution C, dynein complex regulator)
Type: protein-coding
Summary: This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: cell division, establishment of organelle localization, mitotic metaphase chromosome alignment, mitotic spindle organization, nuclear migration, protein folding, response to peptide hormone; MF: cadherin binding, protein binding, unfolded protein binding; CC: cytoplasm, cytoskeleton, cytosol, microtubule, midbody, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Ciliary landscape, EML4 and NUDC in mitotic spindle formation, Lissencephaly gene (LIS1) in neuronal migration and development, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RND2 GTPase cycle, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y266
Entrez ID: 10726
|
Does Knockout of PTBP3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
PTBP3
|
cell proliferation
|
Cancer Cell Line
|
Gene: PTBP3 (polypyrimidine tract binding protein 3)
Type: protein-coding
Summary: The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: RNA splicing, anatomical structure morphogenesis, cell differentiation, erythrocyte maturation, mRNA processing, negative regulation of RNA splicing, regulation of RNA splicing, regulation of cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding; CC: nucleus
Pathways:
UniProt: O95758
Entrez ID: 9991
|
Does Knockout of WNK4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
WNK4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: WNK4 (WNK lysine deficient protein kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
Gene Ontology: BP: ERK1 and ERK2 cascade, aldosterone secretion, calcium ion homeostasis, cellular response to xenobiotic stimulus, chloride transport, distal tubule morphogenesis, gene expression, homeostatic process, inflammatory response, intracellular chloride ion homeostasis, intracellular protein localization, intracellular signal transduction, macrophage activation, monoatomic ion homeostasis, negative regulation of pancreatic juice secretion, negative regulation of protein localization to plasma membrane, negative regulation of sodium ion transport, potassium ion transmembrane transport, protein phosphorylation, regulation of blood pressure, regulation of potassium ion export across plasma membrane, renal sodium ion absorption, renal sodium ion transport, response to dietary excess, response to xenobiotic stimulus, signal transduction, sodium ion transmembrane transport; MF: ATP binding, chloride ion binding, ion channel inhibitor activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: anchoring junction, bicellular tight junction, cell body, cytoplasm, cytosol, membrane, protein-containing complex
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q96J92
Entrez ID: 65266
|
Does Knockout of FGF22 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
FGF22
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: FGF22 (fibroblast growth factor 22)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cell differentiation, fibroblast growth factor receptor signaling pathway, neurogenesis, positive regulation of MAPK cascade, positive regulation of cell population proliferation, regulation of cell migration, regulation of synapse maturation, trans-synaptic signaling; MF: fibroblast growth factor receptor binding, growth factor activity; CC: GABA-ergic synapse, Golgi apparatus, cell surface, cytoplasm, extracellular region, extracellular space, extrinsic component of postsynaptic density membrane, glutamatergic synapse, nucleolus, postsynapse
Pathways: Activated point mutants of FGFR2, Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, ESC Pluripotency Pathways, FGFR1 ligand binding and activation, FGFR1b ligand binding and activation, FGFR2 ligand binding and activation, FGFR2 mutant receptor activation, FGFR2b ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Gastric cancer - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Melanoma - Homo sapiens (human), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Homo sapiens (human), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q9HCT0
Entrez ID: 27006
|
Does Knockout of ZMAT1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ZMAT1
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZMAT1 (zinc finger matrin-type 1)
Type: protein-coding
Summary: This gene encodes a protein containing Cys2-His2 (C2H2)-type zinc fingers, which are similar to those found in the nuclear matrix protein matrin 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology: MF: DNA binding, metal ion binding, nucleic acid binding, zinc ion binding
Pathways:
UniProt: Q5H9K5
Entrez ID: 84460
|
Does Knockout of ADAT3 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
ADAT3
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: ADAT3 (adenosine deaminase tRNA specific 3)
Type: protein-coding
Summary: This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016].
Gene Ontology: MF: catalytic activity, metal ion binding, protein binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q96EY9
Entrez ID: 113179
|
Does Knockout of ICAM1 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
ICAM1
|
response to chemicals
|
Melanoma Cell Line
|
Gene: ICAM1 (intercellular adhesion molecule 1)
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, T cell antigen processing and presentation, T cell extravasation, adhesion of symbiont to host, cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cellular response to amyloid-beta, cellular response to glucose stimulus, cellular response to leukemia inhibitory factor, cellular response to oxygen-containing compound, establishment of endothelial barrier, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, immune effector process, immune response, leukocyte cell-cell adhesion, leukocyte migration, membrane to membrane docking, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of ERK1 and ERK2 cascade, positive regulation of cellular extravasation, receptor-mediated virion attachment to host cell, regulation of leukocyte mediated cytotoxicity, regulation of ruffle assembly, symbiont entry into host cell; MF: integrin binding, protein binding, signaling receptor activity, transmembrane signaling receptor activity, virus receptor activity; CC: cell surface, external side of plasma membrane, extracellular exosome, extracellular matrix, extracellular space, focal adhesion, immunological synapse, membrane, membrane raft, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Adaptive Immune System, African trypanosomiasis - Homo sapiens (human), Beta2 integrin cell surface interactions, CAMKK2 Pathway, Cell adhesion molecules - Homo sapiens (human), Cells and molecules involved in local acute inflammatory response, Complement system, Cytokine Signaling in Immune system, Epstein-Barr virus infection - Homo sapiens (human), Extracellular matrix organization, Fluid shear stress and atherosclerosis - Homo sapiens (human), Folate Metabolism, Glucocorticoid receptor regulatory network, Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL-18 signaling pathway, IL1 and megakaryocytes in obesity, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Influenza A - Homo sapiens (human), Integrin cell surface interactions, Interferon Signaling, Interferon gamma signaling, Interleukin-10 signaling, Interleukin-11 Signaling Pathway, Interleukin-4 and Interleukin-13 signaling, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Malaria - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Netrin-UNC5B signaling pathway, Photodynamic therapy-induced NF-kB survival signaling, RANKL-RANK signaling pathway, Rheumatoid arthritis - Homo sapiens (human), Selenium Micronutrient Network, Signaling by Interleukins, Spinal Cord Injury, Staphylococcus aureus infection - Homo sapiens (human), TNF signaling pathway - Homo sapiens (human), Thromboxane A2 receptor signaling, Type II interferon signaling (IFNG), VEGFA-VEGFR2 Signaling Pathway, Viral myocarditis - Homo sapiens (human), Vitamin B12 metabolism, amb2 Integrin signaling, miRNAs involvement in the immune response in sepsis, p53 transcriptional gene network
UniProt: P05362
Entrez ID: 3383
|
Does Knockout of PRODH2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
PRODH2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PRODH2 (proline dehydrogenase 2)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the first step in the catabolism of trans-4-hydroxy-L-proline, an amino acid derivative obtained through food intake and collagen turnover. One of the downstream products of this catabolism is glyoxylate, which in people with disorders of glyoxalate metabolism can lead to an increase in oxalate levels and the formation of calcium-oxalate kidney stones. Therefore, this gene may serve as a therapeutic target against primary hyperoxalurias (PH). This gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme that catalyzes the first step in proline catabolism. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: L-proline catabolic process, L-proline catabolic process to L-glutamate, proline metabolic process; MF: FAD binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH group of donors, proline dehydrogenase activity; CC: mitochondrial inner membrane, mitochondrion
Pathways: 4-hydroxyproline degradation, Arginine and proline metabolism - Homo sapiens (human), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Proline catabolism
UniProt: Q9UF12
Entrez ID: 58510
|
Does Knockout of UBE2M in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
UBE2M
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: UBE2M (ubiquitin conjugating enzyme E2 M)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: post-translational protein modification, protein modification by small protein conjugation, protein modification process, protein neddylation, regulation of postsynapse assembly; MF: ATP binding, NEDD8 conjugating enzyme activity, NEDD8 transferase activity, nucleotide binding, protein binding, transferase activity, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity; CC: cytosol, glutamatergic synapse, nucleoplasm, nucleus, postsynapse, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Immune System, Innate Immune System, Metabolism of proteins, NIK-->noncanonical NF-kB signaling, Neddylation, Post-translational protein modification, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNFR2 non-canonical NF-kB pathway, Ubiquitin mediated proteolysis - Homo sapiens (human), Validated nuclear estrogen receptor alpha network, Validated nuclear estrogen receptor beta network, regulation of p27 phosphorylation during cell cycle progression
UniProt: P61081
Entrez ID: 9040
|
Does Knockout of ZNF85 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
ZNF85
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZNF85 (zinc finger protein 85)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: Q03923
Entrez ID: 7639
|
Does Knockout of RAB11FIP4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
RAB11FIP4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RAB11FIP4 (RAB11 family interacting protein 4)
Type: protein-coding
Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: endocytic recycling, neural retina development, positive regulation of G1 to G0 transition, regulation of cytokinesis; MF: calcium ion binding, metal ion binding, protein binding, protein homodimerization activity, small GTPase binding; CC: Golgi apparatus, centrosome, cleavage furrow, cytoplasm, cytoplasmic vesicle, cytoskeleton, endocytic vesicle, endosome, extracellular space, membrane, midbody, perinuclear region of cytoplasm, recycling endosome membrane, spindle
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q86YS3
Entrez ID: 84440
|
Does Knockout of NOP9 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
NOP9
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NOP9 (NOP9 nucleolar protein)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: biological_process, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit export from nucleus; MF: RNA binding; CC: 90S preribosome, cellular_component, nucleolus, preribosome, small subunit precursor
Pathways:
UniProt: Q86U38
Entrez ID: 161424
|
Does Knockout of TMA16 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
TMA16
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TMA16 (translation machinery associated 16 homolog)
Type: protein-coding
Summary: Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; MF: preribosome binding, protein binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q96EY4
Entrez ID: 55319
|
Does Knockout of DDX52 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DDX52
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DDX52 (DExD-box helicase 52)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y2R4
Entrez ID: 11056
|
Does Knockout of ZFP42 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
ZFP42
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ZFP42 (ZFP42 zinc finger protein)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: female gonad development, male gonad development, meiotic cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: PcG protein complex, chromatin, cytoplasm, nucleus, transcription regulator complex
Pathways: Cardiac Progenitor Differentiation, Pre-implantation embryo
UniProt: Q96MM3
Entrez ID: 132625
|
Does Knockout of PYGO2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
PYGO2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: PYGO2 (pygopus family PHD finger 2)
Type: protein-coding
Summary: Predicted to enable several functions, including chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and regulation of histone H3-K4 methylation. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, brain development, canonical Wnt signaling pathway, developmental growth, kidney development, lens development in camera-type eye, mammary gland development, regulation of mammary gland epithelial cell proliferation, roof of mouth development, spermatid development, spermatid nucleus differentiation; MF: chromatin binding, histone acetyltransferase regulator activity, histone binding, metal ion binding, protein binding, zinc ion binding; CC: beta-catenin-TCF complex, nucleoplasm, nucleus
Pathways: 1q21.1 copy number variation syndrome, Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q9BRQ0
Entrez ID: 90780
|
Does Knockout of INTS6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
INTS6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: INTS6 (integrator complex subunit 6)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, protein localization to chromatin, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein binding, protein-macromolecule adaptor activity, transmembrane signaling receptor activity; CC: INTAC complex, actin cytoskeleton, chromatin, chromosome, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9UL03
Entrez ID: 26512
|
Does Knockout of C15orf32 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
C15orf32
|
response to chemicals
|
Melanoma Cell Line
|
Gene: C15orf32 (chromosome 15 putative open reading frame 32)
Type: ncRNA
Summary: chromosome 15 putative open reading frame 32
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 145858
|
Does Activation of AIP in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
AIP
|
protein/peptide accumulation
|
T cell
|
Gene: AIP (AHR interacting HSP90 co-chaperone)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: positive regulation of DNA-templated transcription, protein maturation, protein targeting to mitochondrion, xenobiotic metabolic process; MF: GAF domain binding, aryl hydrocarbon receptor binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, transcription coactivator activity, transcription coregulator activity, unfolded protein binding; CC: aryl hydrocarbon receptor complex, cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane
Pathways: Aryl Hydrocarbon Receptor Netpath, Aryl Hydrocarbon Receptor Pathway, Aryl hydrocarbon receptor signalling, Biological oxidations, Cushing syndrome - Homo sapiens (human), Cytokine Signaling in Immune system, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Metabolism, Nuclear Receptors Meta-Pathway, Phase I - Functionalization of compounds, Signaling by Interleukins, ahr signal transduction pathway
UniProt: O00170
Entrez ID: 9049
|
Does Knockout of IKZF1 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
IKZF1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: IKZF1 (IKAROS family zinc finger 1)
Type: protein-coding
Summary: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014].
Gene Ontology: BP: chromatin organization, erythrocyte differentiation, lymphocyte differentiation, mesoderm development, negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, protein domain specific binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, pericentric heterochromatin, protein-containing complex
Pathways: Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Development of pulmonary dendritic cells and macrophage subsets
UniProt: Q13422
Entrez ID: 10320
|
Does Knockout of OR52W1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
OR52W1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: OR52W1 (olfactory receptor family 52 subfamily W member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, nervous system process, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q6IF63
Entrez ID: 120787
|
Does Knockout of POLD1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
POLD1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: POLD1 (DNA polymerase delta 1, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, base-excision repair, gap-filling, cellular response to UV, error-free translesion synthesis, fatty acid homeostasis, nucleotide-excision repair, DNA gap filling, response to UV; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, chromatin binding, damaged DNA binding, enzyme binding, exonuclease activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: aggresome, chromosome, telomeric region, cytosol, delta DNA polymerase complex, membrane, nucleoplasm, nucleotide-excision repair complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cytosolic iron-sulfur cluster assembly, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Nucleotide metabolism, PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P28340
Entrez ID: 5424
|
Does Knockout of HELZ2 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
HELZ2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: HELZ2 (helicase with zinc finger 2)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulatory ncRNA-mediated post-transcriptional gene silencing; MF: 3'-5'-RNA exonuclease activity, ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, RNA nuclease activity, exonuclease activity, exoribonuclease II activity, helicase activity, hydrolase activity, metal ion binding, nuclease activity, nucleotide binding, protein binding, transcription coactivator activity, zinc ion binding; CC: P granule, cytoplasm, cytosol, membrane, nucleoplasm
Pathways: Activation of gene expression by SREBF (SREBP), Adipogenesis, BMAL1:CLOCK,NPAS2 activates circadian expression, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Cytoprotection by HMOX1, Developmental Biology, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Heme signaling, Metabolism, Metabolism of lipids, Metabolism of steroids, Mitochondrial biogenesis, Organelle biogenesis and maintenance, PPARA activates gene expression, RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation of white adipocyte differentiation
UniProt: Q9BYK8
Entrez ID: 85441
|
Does Knockout of ISCU in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
ISCU
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, intracellular iron ion homeostasis, iron-sulfur cluster assembly, negative regulation of iron ion import across plasma membrane, positive regulation of mitochondrial electron transport, NADH to ubiquinone; MF: 2 iron, 2 sulfur cluster binding, ferrous iron binding, iron ion binding, iron-sulfur cluster binding, iron-sulfur cluster chaperone activity, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial matrix, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Respiratory electron transport
UniProt: Q9H1K1
Entrez ID: 23479
|
Does Knockout of FNDC1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
FNDC1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FNDC1 (fibronectin type III domain containing 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q4ZHG4
Entrez ID: 84624
|
Does Knockout of CEPT1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
CEPT1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: CEPT1 (choline/ethanolamine phosphotransferase 1)
Type: protein-coding
Summary: This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: CDP-choline pathway, lipid metabolic process, phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process; MF: 1-alkenyl-2-acylglycerol choline phosphotransferase activity, diacylglycerol cholinephosphotransferase activity, ethanolaminephosphotransferase activity, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, protein binding, transferase activity; CC: Golgi apparatus, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: Ether lipid metabolism - Homo sapiens (human), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Kennedy pathway from sphingolipids, Metabolism, Metabolism of lipids, One-carbon metabolism and related pathways, Phospholipid metabolism, Phosphonate and phosphinate metabolism - Homo sapiens (human), Plasmalogen Synthesis, Synthesis of PC, Synthesis of PE, phosphatidylcholine biosynthesis, phosphatidylcholine biosynthesis pathway, phosphatidylethanolamine biosynthesis II
UniProt: Q9Y6K0
Entrez ID: 10390
|
Does Knockout of SYF2 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
SYF2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SYF2 (SYF2 pre-mRNA splicing factor)
Type: protein-coding
Summary: This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, embryonic organ development, gastrulation, in utero embryonic development, mRNA processing, mRNA splicing, via spliceosome, mitotic G2 DNA damage checkpoint signaling, positive regulation of cell population proliferation; MF: RNA binding, protein binding; CC: Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, nuclear speck, nucleoplasm, nucleus, post-mRNA release spliceosomal complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O95926
Entrez ID: 25949
|
Does Knockout of GTPBP2 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
GTPBP2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: GTPBP2 (GTP binding protein 2)
Type: protein-coding
Summary: GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003].
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, no-go decay, rescue of stalled ribosome, translational elongation; MF: GTP binding, GTPase activity, alpha-aminoacyl-tRNA binding, identical protein binding, nucleotide binding, protein binding, translation elongation factor activity; CC: extracellular region, platelet alpha granule lumen
Pathways: Hemostasis, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9BX10
Entrez ID: 54676
|
Does Knockout of HSP90B1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
HSP90B1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: HSP90B1 (heat shock protein 90 beta family member 1)
Type: protein-coding
Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: ERAD pathway, actin rod assembly, cellular response to ATP, cellular response to manganese ion, negative regulation of apoptotic process, positive regulation of Wnt signaling pathway, positive regulation of toll-like receptor signaling pathway, protein folding, protein folding in endoplasmic reticulum, protein localization to plasma membrane, protein transport, response to endoplasmic reticulum stress, response to hypoxia, retrograde protein transport, ER to cytosol, sequestering of calcium ion; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, calcium ion binding, hydrolase activity, low-density lipoprotein particle receptor binding, nucleotide binding, protein binding, protein folding chaperone, protein phosphatase binding, protein phosphatase inhibitor activity, unfolded protein binding; CC: cytosol, endocytic vesicle lumen, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular exosome, extracellular region, focal adhesion, melanosome, membrane, midbody, nucleus, perinuclear region of cytoplasm, protein-containing complex, sarcoplasmic reticulum, sarcoplasmic reticulum lumen, smooth endoplasmic reticulum, sperm plasma membrane
Pathways: ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, AndrogenReceptor, Binding and Uptake of Ligands by Scavenger Receptors, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Estrogen signaling pathway - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL6-mediated signaling events, Immune System, Innate Immune System, Interleukin-4 and Interleukin-13 signaling, Lipid and atherosclerosis - Homo sapiens (human), Metabolism of proteins, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Post-translational protein modification, Post-translational protein phosphorylation, Prion disease pathway, Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Salmonella infection - Homo sapiens (human), Scavenging by Class A Receptors, Signaling by Interleukins, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Thyroid hormone synthesis - Homo sapiens (human), Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR, Unfolded Protein Response (UPR), Vesicle-mediated transport
UniProt: P14625
Entrez ID: 7184
|
Does Knockout of NLRP2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
NLRP2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: NLRP2 (NLR family pyrin domain containing 2)
Type: protein-coding
Summary: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: apoptotic process, immune system process, inflammatory response, innate immune response, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of interleukin-1 beta production, regulation of inflammatory response, regulation of interleukin-1 beta production; MF: ATP binding, Pyrin domain binding, nucleotide binding, protein binding; CC: Golgi apparatus, chromosome, telomeric region, cytoplasm, cytosol, intracellular membrane-bounded organelle
Pathways: Nucleotide-binding Oligomerization Domain (NOD) pathway
UniProt: Q9NX02
Entrez ID: 55655
|
Does Knockout of ZMYND12 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
ZMYND12
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZMYND12 (zinc finger MYND-type containing 12)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: flagellated sperm motility, sperm axoneme assembly; MF: metal ion binding, protein binding, zinc ion binding; CC: cell projection, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q9H0C1
Entrez ID: 84217
|
Does Knockout of AAK1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
AAK1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: AAK1 (AP2 associated kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: endocytosis, membrane organization, positive regulation of Notch signaling pathway, presynaptic endocytosis, protein phosphorylation, protein stabilization, regulation of clathrin-dependent endocytosis, regulation of protein localization; MF: AP-2 adaptor complex binding, ATP binding, Notch binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell leading edge, cell projection, clathrin-coated pit, clathrin-coated vesicle, cytosol, membrane, plasma membrane, presynapse, synapse, terminal bouton
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q2M2I8
Entrez ID: 22848
|
Does Knockout of DNMT1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
DNMT1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: DNMT1 (DNA methyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, DNA-templated transcription, cellular response to amino acid stimulus, cellular response to bisphenol A, chromatin organization, chromosomal DNA methylation maintenance following DNA replication, epigenetic programming of gene expression, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell apoptotic process, negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, positive regulation of gene expression, positive regulation of vascular associated smooth muscle cell proliferation, regulation of cell population proliferation, regulation of gene expression; MF: DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA-methyltransferase activity, RNA binding, chromatin binding, lncRNA binding, metal ion binding, methyl-CpG binding, methyltransferase activity, promoter-specific chromatin binding, protein binding, transferase activity, zinc ion binding; CC: female germ cell nucleus, germ cell nucleus, heterochromatin, mitochondrion, nucleoplasm, nucleus, pericentric heterochromatin, replication fork
Pathways: Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), DNA methylation, Defective pyroptosis, Disease, Diseases of programmed cell death, Diseases of signal transduction by growth factor receptors and second messengers, Epigenetic regulation of gene expression, Gene expression (Transcription), Glycine N-methyltransferase Deficiency, Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, MTHFR deficiency, Metabolism of proteins, Methionine Adenosyltransferase Deficiency, Methionine Metabolism, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), MicroRNAs in cancer - Homo sapiens (human), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nuclear events stimulated by ALK signaling in cancer, One-carbon metabolism, PRC2 methylates histones and DNA, Post-translational protein modification, Regulation of retinoblastoma protein, Retinoblastoma gene in cancer, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, STAT3 nuclear events downstream of ALK signaling, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA methylation proteins, Signal Transduction, Signaling by ALK, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Receptor Tyrosine Kinases, Trans-sulfuration and one-carbon metabolism, Trans-sulfuration pathway
UniProt: P26358
Entrez ID: 1786
|
Does Knockout of COX11 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
COX11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: COX11 (cytochrome c oxidase copper chaperone COX11)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: ATP biosynthetic process, intracellular monoatomic cation homeostasis; MF: copper ion binding, electron transfer activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, protein-containing complex
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Copper homeostasis, Electron Transport Chain (OXPHOS system in mitochondria), Metabolism, Mitochondrial CIV Assembly, Oxidative phosphorylation - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q9Y6N1
Entrez ID: 1353
|
Does Knockout of MS4A15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
MS4A15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MS4A15 (membrane spanning 4-domains A15)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q8N5U1
Entrez ID: 219995
|
Does Knockout of MCM4 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
MCM4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: MCM4 (minichromosome maintenance complex component 4)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, double-strand break repair via break-induced replication, mitotic DNA replication initiation, regulation of DNA-templated DNA replication initiation; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, chromosome, telomeric region, membrane, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, C-MYB transcription factor network, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Gastric Cancer Network 1, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Retinoblastoma gene in cancer, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, Unwinding of DNA, cdk regulation of dna replication
UniProt: P33991
Entrez ID: 4173
|
Does Knockout of TSSK3 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
TSSK3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TSSK3 (testis specific serine kinase 3)
Type: protein-coding
Summary: This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, protein phosphorylation, spermatid development, spermatogenesis; MF: ATP binding, kinase activity, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q96PN8
Entrez ID: 81629
|
Does Knockout of ATP6AP1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
ATP6AP1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ATP6AP1 (ATPase H+ transporting accessory protein 1)
Type: protein-coding
Summary: This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: Golgi lumen acidification, cellular response to increased oxygen levels, endosomal lumen acidification, endosome to plasma membrane protein transport, intracellular iron ion homeostasis, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, osteoclast development, proton transmembrane transport, regulation of cellular pH, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATPase activator activity, protein binding, small GTPase binding, transporter activator activity; CC: Golgi membrane, bounding membrane of organelle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome membrane, extracellular exosome, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex, synapse, synaptic vesicle membrane
Pathways: Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human papillomavirus infection - Homo sapiens (human), Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), RHO GTPase cycle, RHOA GTPase cycle, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human)
UniProt: Q15904
Entrez ID: 537
|
Does Knockout of ZNF35 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ZNF35
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ZNF35 (zinc finger protein 35)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to retinoic acid, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: cytoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: P13682
Entrez ID: 7584
|
Does Knockout of ABCG5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
ABCG5
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ABCG5 (ATP binding cassette subfamily G member 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cholesterol efflux, cholesterol homeostasis, intestinal cholesterol absorption, lipid transport, negative regulation of intestinal cholesterol absorption, negative regulation of intestinal phytosterol absorption, response to ionizing radiation, response to muscle activity, response to nutrient, response to nutrient levels, response to xenobiotic stimulus, sterol transport, transmembrane transport, triglyceride homeostasis; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, cholesterol transfer activity, metal ion binding, nucleotide binding, protein binding, protein dimerization activity, protein heterodimerization activity; CC: ATP-binding cassette (ABC) transporter complex, apical part of cell, apical plasma membrane, membrane, plasma membrane, receptor complex
Pathways: ABC transporter disorders, ABC transporters - Homo sapiens (human), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Angiopoietin Like Protein 8 Regulatory Pathway, Bile acids synthesis and enterohepatic circulation, Bile secretion - Homo sapiens (human), Cholesterol metabolism - Homo sapiens (human), Defective ABCG5 causes sitosterolemia, Defective ABCG8 causes GBD4 and sitosterolemia, Disease, Disorders of transmembrane transporters, Fat digestion and absorption - Homo sapiens (human), Liver X receptor pathway, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Nuclear Receptors Meta-Pathway, Nuclear Receptors in Lipid Metabolism and Toxicity, Signal Transduction, Signaling by Nuclear Receptors, Statin inhibition of cholesterol production, Transport of small molecules, Vitamin A and carotenoid metabolism
UniProt: Q9H222
Entrez ID: 64240
|
Does Knockout of VPS52 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
VPS52
|
cell proliferation
|
Cancer Cell Line
|
Gene: VPS52 (VPS52 subunit of GARP complex)
Type: protein-coding
Summary: This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: Golgi to vacuole transport, ectodermal cell differentiation, embryonic ectodermal digestive tract development, endocytic recycling, lysosomal transport, protein targeting, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated cholesterol transport; MF: protein binding, syntaxin binding; CC: EARP complex, GARP complex, Golgi apparatus, cytosol, endosome, endosome membrane, membrane, perinuclear region of cytoplasm, postsynapse, presynapse, recycling endosome, trans-Golgi network membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q8N1B4
Entrez ID: 6293
|
Does Knockout of PTH2 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
PTH2
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: PTH2 (parathyroid hormone 2)
Type: protein-coding
Summary: This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015].
Gene Ontology: CC: extracellular region
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q96A98
Entrez ID: 113091
|
Does Knockout of TNC in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
TNC
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TNC (tenascin C)
Type: protein-coding
Summary: This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: bud outgrowth involved in lung branching, cell adhesion, cellular response to prostaglandin D stimulus, cellular response to retinoic acid, cellular response to vitamin D, mesenchymal-epithelial cell signaling involved in prostate gland development, morphogenesis of an epithelium, negative regulation of cell adhesion, neuromuscular junction development, neuron projection development, odontogenesis of dentin-containing tooth, osteoblast differentiation, peripheral nervous system axon regeneration, positive regulation of cell population proliferation, positive regulation of gene expression, prostate gland epithelium morphogenesis, regulation of cell adhesion, regulation of cell growth, regulation of cell migration, regulation of inflammatory response, response to ethanol, response to fibroblast growth factor, response to mechanical stimulus, response to wounding; MF: extracellular matrix structural constituent, integrin binding, protein binding, syndecan binding; CC: basement membrane, endoplasmic reticulum lumen, extracellular matrix, extracellular matrix of synaptic cleft, extracellular region, extracellular space, focal adhesion, glutamatergic synapse, interstitial matrix, membrane, perisynaptic extracellular matrix, tenascin complex
Pathways: Alpha9 beta1 integrin signaling events, Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, Beta1 integrin cell surface interactions, Beta3 integrin cell surface interactions, ECM proteoglycans, ECM-receptor interaction - Homo sapiens (human), Extracellular matrix organization, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Integrin cell surface interactions, Metabolism of proteins, MicroRNAs in cancer - Homo sapiens (human), Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Syndecan interactions, Syndecan-4-mediated signaling events, TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, TGF-beta Signaling Pathway
UniProt: P24821
Entrez ID: 3371
|
Does Knockout of RNMT in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
RNMT
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: RNMT (RNA guanine-7 methyltransferase)
Type: protein-coding
Summary: Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 7-methylguanosine mRNA capping, RNA 5'-cap (guanine-N7)-methylation, cellular response to leukemia inhibitory factor, mRNA processing, methylation; MF: RNA binding, mRNA 5'-cap (guanine-N7-)-methyltransferase activity, methyltransferase activity, protein binding, transferase activity; CC: fibrillar center, mRNA cap methyltransferase RNMT:RAMAC complex, mRNA capping enzyme complex, nucleoplasm, nucleus, receptor complex
Pathways: Disease, Gene expression (Transcription), HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase II Transcription, Transcription of the HIV genome, Viral Infection Pathways, mRNA Capping, mRNA Processing, mRNA capping, mRNA surveillance pathway - Homo sapiens (human)
UniProt: O43148
Entrez ID: 8731
|
Does Knockout of PINX1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
PINX1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1)
Type: protein-coding
Summary: Enables telomerase RNA binding activity and telomerase inhibitor activity. Involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitotic metaphase chromosome alignment, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell population proliferation, negative regulation of protein ubiquitination, negative regulation of telomere maintenance via telomerase, negative regulation of telomere maintenance via telomere lengthening, positive regulation of protein localization to nucleolus, protein localization to chromosome, telomeric region, protein localization to nucleolus, regulation of protein stability, telomere maintenance via telomerase; MF: nucleic acid binding, protein binding, protein-containing complex binding, telomerase RNA binding, telomerase inhibitor activity; CC: chromosome, chromosome, centromeric region, chromosome, telomeric region, kinetochore, mitochondrion, nuclear chromosome, nucleolus, nucleoplasm, nucleus, spindle
Pathways: Regulation of Telomerase
UniProt: Q96BK5
Entrez ID: 54984
|
Does Knockout of ATP2A2 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
ATP2A2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)
Type: protein-coding
Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019].
Gene Ontology: BP: ER-nucleus signaling pathway, T-tubule organization, autophagosome assembly, autophagosome membrane docking, calcium ion import into sarcoplasmic reticulum, calcium ion transmembrane transport, calcium ion transport, calcium ion transport from cytosol to endoplasmic reticulum, cardiac muscle hypertrophy in response to stress, cell adhesion, cellular response to oxidative stress, endoplasmic reticulum calcium ion homeostasis, epidermis development, intracellular calcium ion homeostasis, mitochondrion-endoplasmic reticulum membrane tethering, monoatomic ion transmembrane transport, monoatomic ion transport, muscle system process, negative regulation of heart contraction, neuron cellular homeostasis, organelle localization by membrane tethering, positive regulation of cardiac muscle cell apoptotic process, positive regulation of endoplasmic reticulum calcium ion concentration, positive regulation of heart rate, regulation of calcium ion-dependent exocytosis of neurotransmitter, regulation of cardiac conduction, regulation of cardiac muscle cell action potential involved in regulation of contraction, regulation of cardiac muscle cell membrane potential, regulation of cardiac muscle contraction by calcium ion signaling, regulation of muscle contraction, regulation of the force of heart contraction, relaxation of cardiac muscle, response to endoplasmic reticulum stress, sarcoplasmic reticulum calcium ion transport, transition between fast and slow fiber; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential, S100 protein binding, calcium channel regulator activity, calcium ion binding, enzyme binding, lncRNA binding, metal ion binding, nucleotide binding, protein binding, transmembrane transporter binding; CC: calcium ion-transporting ATPase complex, endoplasmic reticulum, endoplasmic reticulum membrane, intercalated disc, longitudinal sarcoplasmic reticulum, membrane, plasma membrane, platelet dense tubular network membrane, ribbon synapse, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Acebutolol Action Pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alprenolol Action Pathway, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Atenolol Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Carteolol Action Pathway, Carvedilol Action Pathway, Diabetic cardiomyopathy - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Endothelin Pathways, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Hypertrophic cardiomyopathy - Homo sapiens (human), Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle/Heart Contraction, Myometrial relaxation and contraction pathways, Nadolol Action Pathway, Nebivolol Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Pancreatic secretion - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Spinocerebellar ataxia - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), nfat and hypertrophy of the heart
UniProt: P16615
Entrez ID: 488
|
Does Knockout of OR52K2 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
OR52K2
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: OR52K2 (olfactory receptor family 52 subfamily K member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, nervous system process, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGK3
Entrez ID: 119774
|
Does Knockout of TUBG1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
TUBG1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: TUBG1 (tubulin gamma 1)
Type: protein-coding
Summary: This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic spindle organization, microtubule cytoskeleton organization, microtubule nucleation, microtubule-based process, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization; MF: GTP binding, identical protein binding, microtubule nucleator activity, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: apical part of cell, cell leading edge, centriole, centrosome, ciliary basal body, cilium, condensed nuclear chromosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule cytoskeleton, mitotic spindle microtubule, neuron projection, non-motile cilium, nucleus, pericentriolar material, polar microtubule, recycling endosome, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Human papillomavirus infection - Homo sapiens (human), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, PLK1 signaling events, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P23258
Entrez ID: 7283
|
Does Knockout of PPIAL4F in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
PPIAL4F
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PPIAL4F (peptidylprolyl isomerase A like 4F)
Type: protein-coding
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein folding; MF: cyclosporin A binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: cytoplasm
Pathways:
UniProt: P0DN26
Entrez ID: 728945
|
Does Knockout of TOX3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TOX3
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TOX3 (TOX high mobility group box family member 3)
Type: protein-coding
Summary: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009].
Gene Ontology: BP: apoptotic process, negative regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process, regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin DNA binding, chromatin binding, phosphoprotein binding, protein binding, protein homodimerization activity, transcription coactivator activity; CC: cytosol, nucleoplasm, nucleus
Pathways: Ectoderm Differentiation, Mesodermal commitment pathway
UniProt: O15405
Entrez ID: 27324
|
Does Knockout of ALPL in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
ALPL
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ALPL (alkaline phosphatase, biomineralization associated)
Type: protein-coding
Summary: This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: biomineral tissue development, bone mineralization, calcium ion homeostasis, cellular homeostasis, cementum mineralization, developmental process involved in reproduction, endochondral ossification, futile creatine cycle, inhibition of non-skeletal tissue mineralization, osteoblast differentiation, phosphate ion homeostasis, positive regulation of cold-induced thermogenesis, pyridoxal phosphate metabolic process, response to antibiotic, response to glucocorticoid, response to insulin, response to lipopolysaccharide, response to macrophage colony-stimulating factor, response to sodium phosphate, response to vitamin B6, response to vitamin D, skeletal system development; MF: ADP phosphatase activity, ATP hydrolysis activity, alkaline phosphatase activity, calcium ion binding, hydrolase activity, inorganic diphosphate phosphatase activity, metal ion binding, phosphatase activity, phosphoamidase activity, phosphoethanolamine phosphatase activity, pyridoxal phosphatase activity, pyrophosphatase activity; CC: extracellular exosome, extracellular matrix, extracellular membrane-bounded organelle, extracellular region, extracellular space, membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, plasma membrane, side of membrane
Pathways: AGE-RAGE pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, FGF23 signaling in hypophosphatemic rickets and related disorders, Folate biosynthesis - Homo sapiens (human), Hypophosphatasia, Mammary gland development pathway - Embryonic development (Stage 1 of 4), Metabolism of proteins, NOTCH1 regulation of endothelial cell calcification, Netrin-UNC5B signaling pathway, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Role of Osx and miRNAs in tooth development, TNFalpha, Thiamine metabolism - Homo sapiens (human), Vitamin B6 Metabolism, regulators of bone mineralization
UniProt: P05186
Entrez ID: 249
|
Does Knockout of RGPD6 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RGPD6
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RGPD6 (RANBP2 like and GRIP domain containing 6)
Type: protein-coding
Summary: Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, protein binding; CC: cytoplasm, nuclear pore
Pathways:
UniProt: Q99666
Entrez ID: 729540
|
Does Knockout of NCOR2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
NCOR2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NCOR2 (nuclear receptor corepressor 2)
Type: protein-coding
Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011].
Gene Ontology: BP: cerebellum development, estrous cycle, lactation, negative regulation of DNA-templated transcription, negative regulation of androgen receptor signaling pathway, negative regulation of miRNA transcription, negative regulation of transcription by RNA polymerase II, regulation of ketone metabolic process, response to estradiol; MF: DNA binding, Notch binding, chromatin binding, enzyme activator activity, histone deacetylase binding, nuclear glucocorticoid receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, protein binding, protein-containing complex binding, transcription corepressor activity; CC: chromatin, membrane, nuclear body, nuclear matrix, nucleoplasm, nucleus, protein-containing complex, transcription repressor complex
Pathways: Adipogenesis, Androgen receptor signaling pathway, AndrogenReceptor, Aryl Hydrocarbon Receptor Netpath, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytoprotection by HMOX1, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of Developmental Biology, Disorders of Nervous System Development, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Epstein-Barr virus infection - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, HCMV Early Events, HCMV Infection, HDACs deacetylate histones, Infectious disease, Loss of MECP2 binding ability to the NCoR/SMRT complex, Loss of function of MECP2 in Rett syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, Metabolism of proteins, NOTCH1 Intracellular Domain Regulates Transcription, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Notch-HLH transcription pathway, Notch-mediated HES/HEY network, Nuclear Receptor transcription pathway, PPARA activates gene expression, Pervasive developmental disorders, Post-translational protein modification, RNA Polymerase II Transcription, RXR and RAR heterodimerization with other nuclear receptor, Regulation of MECP2 expression and activity, Regulation of lipid metabolism by PPARalpha, Retinoic acid receptors-mediated signaling, Rett syndrome causing genes, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by Nuclear Receptors, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Transcriptional Regulation by MECP2, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation of white adipocyte differentiation, Validated nuclear estrogen receptor alpha network, Viral Infection Pathways, map kinase inactivation of smrt corepressor, mechanism of gene regulation by peroxisome proliferators via ppara, mets affect on macrophage differentiation, nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
UniProt: Q9Y618
Entrez ID: 9612
|
Does Knockout of ETV3 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
ETV3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ETV3 (ETS variant transcription factor 3)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, cellular response to granulocyte macrophage colony-stimulating factor stimulus, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DEAD/H-box RNA helicase binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription repressor complex, chromatin, nucleoplasm, nucleus, transcription repressor complex
Pathways: mets affect on macrophage differentiation
UniProt: P41162
Entrez ID: 2117
|
Does Knockout of LMAN1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
LMAN1
|
response to virus
|
Hepatoma Cell Line
|
Gene: LMAN1 (lectin, mannose binding 1)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: Golgi organization, blood coagulation, early endosome to Golgi transport, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, gene expression, in utero embryonic development, negative regulation of protein targeting to mitochondrion, positive regulation of organelle organization, protein exit from endoplasmic reticulum, protein folding, protein transport, vesicle-mediated transport; MF: D-mannose binding, carbohydrate binding, metal ion binding, protein binding, unfolded protein binding; CC: COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, extracellular matrix, membrane, sarcomere
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Complement and Coagulation Cascades, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by TCPTP, Transport to the Golgi and subsequent modification, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport
UniProt: P49257
Entrez ID: 3998
|
Does Knockout of DDX18 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
DDX18
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: DDX18 (DEAD-box helicase 18)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to estradiol stimulus, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: chromosome, membrane, nucleolus, nucleus
Pathways: Validated targets of C-MYC transcriptional activation
UniProt: Q9NVP1
Entrez ID: 8886
|
Does Inhibition of EFR3A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
EFR3A
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EFR3A (EFR3 homolog A)
Type: protein-coding
Summary: The protein encoded by this gene is part of a complex that plays a role in maintaining an active pool of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane. This protein is thought to be a peripheral membrane protein that associates with the plasma membrane through palmitoylation. Studies indicate that this gene product plays a role in controlling G protein-coupled receptor (GPCR) activity by affecting receptor phosphorylation. Whole exome sequencing studies have implicated mutations in this gene with autism spectrum disorders. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: phosphatidylinositol phosphate biosynthetic process, protein localization to plasma membrane, synaptic vesicle priming; CC: cytoplasm, cytosol, glutamatergic synapse, membrane, plasma membrane, presynapse
Pathways:
UniProt: Q14156
Entrez ID: 23167
|
Does Knockout of XRCC3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
XRCC3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: XRCC3 (X-ray repair cross complementing 3)
Type: protein-coding
Summary: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, double-strand break repair via synthesis-dependent strand annealing, interstrand cross-link repair, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of centrosome duplication, resolution of mitotic recombination intermediates, t-circle formation, telomere maintenance via recombination, telomere maintenance via telomere trimming, telomeric loop disassembly; MF: ATP binding, ATP-dependent DNA damage sensor activity, DNA binding, crossover junction DNA endonuclease activity, four-way junction DNA binding, nucleotide binding, protein binding; CC: Rad51C-XRCC3 complex, chromosome, telomeric region, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, perinuclear region of cytoplasm, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway, Fluoropyrimidine Activity, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Integrated breast cancer pathway, Male infertility, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
UniProt: O43542
Entrez ID: 7517
|
Does Knockout of NPLOC4 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
NPLOC4
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: NPLOC4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, Golgi organization, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, protein binding, protein-containing complex binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, endoplasmic reticulum, nuclear outer membrane-endoplasmic reticulum membrane network, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8TAT6
Entrez ID: 55666
|
Does Knockout of POGK in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
POGK
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: POGK (pogo transposable element derived with KRAB domain)
Type: protein-coding
Summary: The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: DNA binding, nucleic acid binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q9P215
Entrez ID: 57645
|
Does Knockout of FAM219B in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
FAM219B
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: FAM219B (family with sequence similarity 219 member B)
Type: protein-coding
Summary: family with sequence similarity 219 member B
Gene Ontology:
Pathways:
UniProt: Q5XKK7
Entrez ID: 57184
|
Does Knockout of CWF19L2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
CWF19L2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CWF19L2 (CWF19 like cell cycle control factor 2)
Type: protein-coding
Summary: Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: nucleoplasm, post-mRNA release spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q2TBE0
Entrez ID: 143884
|
Does Knockout of SLU7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
SLU7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SLU7 (spliceosome associated SLU7)
Type: protein-coding
Summary: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, cellular response to heat, intracellular protein transport, mRNA 3'-splice site recognition, mRNA processing, mRNA splicing, via spliceosome; MF: metal ion binding, pre-mRNA 3'-splice site binding, protein binding, second spliceosomal transesterification activity, zinc ion binding; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, membrane, nuclear speck, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O95391
Entrez ID: 10569
|
Does Knockout of PLK4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
PLK4
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PLK4 (polo like kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: centriole replication, cilium assembly, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation, positive regulation of centriole replication, protein phosphorylation, regulation of cell cycle process, trophoblast giant cell differentiation; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: XY body, centriole, centrosome, cleavage furrow, cytoplasm, cytoskeleton, cytosol, deuterosome, nucleolus, nucleus, procentriole, procentriole replication complex
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Ciliopathies, Cilium Assembly, FoxO signaling pathway - Homo sapiens (human), G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Retinoblastoma gene in cancer
UniProt: O00444
Entrez ID: 10733
|
Does Knockout of ATP8B3 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
ATP8B3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ATP8B3 (ATPase phospholipid transporting 8B3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: Golgi organization, binding of sperm to zona pellucida, establishment of localization in cell, lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylserine floppase activity; CC: acrosomal membrane, acrosomal vesicle, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, phospholipid-translocating ATPase complex, plasma membrane, trans-Golgi network
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: O60423
Entrez ID: 148229
|
Does Knockout of FGF11 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
FGF11
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: FGF11 (fibroblast growth factor 11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: cell-cell signaling, nervous system development, neurogenesis, signal transduction; MF: growth factor activity, protein binding, sodium channel regulator activity; CC: cytoplasm, nucleus
Pathways: Cardiac conduction, ESC Pluripotency Pathways, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, MAPK Signaling Pathway, Muscle contraction, PI3K-Akt signaling pathway, Phase 0 - rapid depolarisation, Regulation of Actin Cytoskeleton
UniProt: Q92914
Entrez ID: 2256
|
Does Knockout of PUSL1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
PUSL1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PUSL1 (pseudouridine synthase like 1)
Type: protein-coding
Summary: Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA modification, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis; MF: RNA binding, isomerase activity, pseudouridine synthase activity, tRNA pseudouridine synthase activity; CC: mitochondrion
Pathways:
UniProt: Q8N0Z8
Entrez ID: 126789
|
Does Knockout of MIR638 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
MIR638
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MIR638 (microRNA 638)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: miRNA-mediated post-transcriptional gene silencing, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of vascular associated smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, platelet-derived growth factor receptor signaling pathway; CC: cytoplasm, extracellular exosome
Pathways:
UniProt:
Entrez ID: 693223
|
Does Knockout of BUB3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
BUB3
|
cell proliferation
|
Cancer Cell Line
|
Gene: BUB3 (BUB3 mitotic checkpoint protein)
Type: protein-coding
Summary: This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, meiotic cell cycle, mitotic spindle assembly checkpoint signaling, protein localization to kinetochore, regulation of chromosome segregation; MF: protein binding, ubiquitin binding; CC: bub1-bub3 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, mitotic checkpoint complex, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p73 transcription factor network
UniProt: O43684
Entrez ID: 9184
|
Does Knockout of TELO2 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
TELO2
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: TELO2 (telomere maintenance 2)
Type: protein-coding
Summary: This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009].
Gene Ontology: BP: 'de novo' cotranslational protein folding, positive regulation of DNA damage checkpoint, protein stabilization; MF: Hsp90 protein binding, molecular adaptor activity, protein binding, protein kinase binding, protein-containing complex binding, telomeric DNA binding; CC: TTT Hsp90 cochaperone complex, chromosome, chromosome, telomeric region, cytoplasm, cytosol, membrane, nuclear body, nucleus
Pathways: Fanconi anemia pathway - Homo sapiens (human), Fragile X Syndrome, mTOR signaling pathway - Homo sapiens (human)
UniProt: Q9Y4R8
Entrez ID: 9894
|
Does Knockout of PPP1R10 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
PPP1R10
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: PPP1R10 (protein phosphatase 1 regulatory subunit 10)
Type: protein-coding
Summary: This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of cardiac muscle cell apoptotic process, negative regulation of mitotic DNA damage checkpoint, negative regulation of transcription elongation by RNA polymerase II, positive regulation of telomere maintenance, positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, positive regulation of transcription elongation by RNA polymerase II, protein import into nucleus, protein stabilization, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, RNA binding, enzyme-substrate adaptor activity, metal ion binding, protein binding, protein phosphatase 1 binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, zinc ion binding; CC: PTW/PP1 phosphatase complex, chromatin, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q96QC0
Entrez ID: 5514
|
Does Knockout of DDX18 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
DDX18
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: DDX18 (DEAD-box helicase 18)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to estradiol stimulus, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: chromosome, membrane, nucleolus, nucleus
Pathways: Validated targets of C-MYC transcriptional activation
UniProt: Q9NVP1
Entrez ID: 8886
|
Does Knockout of ITGB7 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
ITGB7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: ITGB7 (integrin subunit beta 7)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: T cell migration, cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-matrix adhesion, cell-matrix adhesion involved in ameboidal cell migration, heterotypic cell-cell adhesion, immune response in gut-associated lymphoid tissue, integrin-mediated signaling pathway, leukocyte migration, leukocyte tethering or rolling, receptor clustering, substrate adhesion-dependent cell spreading, symbiont entry into host cell; MF: cell adhesion molecule binding, integrin binding, metal ion binding, protein binding, virus receptor activity; CC: cell surface, extracellular exosome, focal adhesion, integrin alpha4-beta7 complex, integrin complex, membrane, plasma membrane, receptor complex
Pathways: AlphaE beta7 integrin cell surface interactions, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Beta5 beta6 beta7 and beta8 integrin cell surface interactions, Cell adhesion molecules - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), E-cadherin signaling in the nascent adherens junction, ECM-receptor interaction - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human papillomavirus infection - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Integrin-mediated Cell Adhesion, Intestinal immune network for IgA production - Homo sapiens (human), Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), a4b7 Integrin signaling
UniProt: P26010
Entrez ID: 3695
|
Does Knockout of PSMC1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
PSMC1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PSMC1 (proteasome 26S subunit, ATPase 1)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, RNA binding, nucleotide binding, proteasome-activating activity, protein binding; CC: cytoplasm, cytosol, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Asparagine N-linked glycosylation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Human papillomavirus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62191
Entrez ID: 5700
|
Does Knockout of PIK3C3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
PIK3C3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, cell division, cellular response to glucose starvation, cellular response to starvation, early endosome to late endosome transport, endocytosis, endosome organization, host-mediated activation of viral genome replication, interleukin-6-mediated signaling pathway, lipid metabolic process, macroautophagy, pexophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of protein lipidation, protein localization to phagophore assembly site, protein processing, protein targeting to lysosome, regulation of autophagy, regulation of cytokinesis, regulation of macroautophagy, response to L-leucine, synaptic vesicle endocytosis, type II interferon-mediated signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, transferase activity; CC: GABA-ergic synapse, autolysosome, autophagosome, axoneme, cytoplasm, cytoplasmic vesicle, cytosol, endosome, glutamatergic synapse, late endosome, membrane, midbody, peroxisome, phagocytic vesicle, phagocytic vesicle membrane, phagophore assembly site, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidylinositol 3-kinase complex, class III, type II, plasma membrane, postsynapse, postsynaptic endosome, presynaptic endosome
Pathways: 3-phosphoinositide biosynthesis, AMP-activated protein kinase (AMPK) signaling, Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Apelin signaling pathway - Homo sapiens (human), Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, DNA damage response (only ATM dependent), Disease, Early SARS-CoV-2 Infection Events, Huntington disease - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Infectious disease, Innate Immune System, Inositol Metabolism, Inositol phosphate metabolism - Homo sapiens (human), Insulin Signaling, Insulin receptor signalling cascade, Joubert syndrome, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Macroautophagy, Metabolism, Metabolism of lipids, Microglia Pathogen Phagocytosis Pathway, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Osteoblast differentiation, PI Metabolism, PI3K Cascade, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, Regulation of Actin Cytoskeleton, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Senescence and Autophagy in Cancer, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spinocerebellar ataxia - Homo sapiens (human), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Translation of Replicase and Assembly of the Replication Transcription Complex, Tuberculosis - Homo sapiens (human), Viral Infection Pathways, superpathway of inositol phosphate compounds
UniProt: Q8NEB9
Entrez ID: 5289
|
Does Knockout of SPATA31A6 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
SPATA31A6
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SPATA31A6 (SPATA31 subfamily A member 6)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, spermatogenesis
Pathways:
UniProt: Q5VVP1
Entrez ID: 389730
|
Does Knockout of APOA4 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
APOA4
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: APOA4 (apolipoprotein A4)
Type: protein-coding
Summary: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acylglycerol homeostasis, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, chylomicron assembly, chylomicron remodeling, high-density lipoprotein particle remodeling, hydrogen peroxide catabolic process, innate immune response in mucosa, leukocyte cell-cell adhesion, lipid catabolic process, lipid homeostasis, lipid transport, lipoprotein metabolic process, negative regulation of plasma lipoprotein oxidation, peripheral nervous system axon regeneration, phosphatidylcholine metabolic process, phospholipid efflux, positive regulation of fatty acid biosynthetic process, positive regulation of triglyceride catabolic process, protein-lipid complex assembly, regulation of cholesterol transport, regulation of intestinal cholesterol absorption, removal of superoxide radicals, response to lipid hydroperoxide, response to stilbenoid, response to stress, response to triglyceride, reverse cholesterol transport, very-low-density lipoprotein particle remodeling; MF: antioxidant activity, cholesterol transfer activity, copper ion binding, identical protein binding, lipid binding, lipid transporter activity, phosphatidylcholine binding, phosphatidylcholine-sterol O-acyltransferase activator activity, phospholipid binding, protein binding, protein homodimerization activity; CC: blood microparticle, cell surface, chylomicron, cytosol, early endosome, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, extracellular vesicle, high-density lipoprotein particle, low-density lipoprotein particle, synapse, very-low-density lipoprotein particle
Pathways: Amyloid fiber formation, Assembly of active LPL and LIPC lipase complexes, Cholesterol metabolism - Homo sapiens (human), Chylomicron assembly, Chylomicron remodeling, Fat digestion and absorption - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Metabolism, Metabolism of fat-soluble vitamins, Metabolism of proteins, Metabolism of vitamins and cofactors, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Retinoid metabolism and transport, Sensory Perception, Statin inhibition of cholesterol production, Transport of small molecules, Visual phototransduction, Vitamin digestion and absorption - Homo sapiens (human)
UniProt: P06727
Entrez ID: 337
|
Does Knockout of HMGCR in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
HMGCR
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Type: protein-coding
Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, coenzyme A metabolic process, isoprenoid biosynthetic process, lipid metabolic process, long-term synaptic potentiation, negative regulation of amyloid-beta clearance, negative regulation of protein catabolic process, negative regulation of protein secretion, regulation of ERK1 and ERK2 cascade, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, visual learning; MF: GTPase regulator activity, NADP binding, NADPH binding, coenzyme A binding, hydroxymethylglutaryl-CoA reductase (NADPH) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, peroxisomal membrane, peroxisome
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK signaling pathway - Homo sapiens (human), Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, Bile secretion - Homo sapiens (human), CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Integrated breast cancer pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, PPARA activates gene expression, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Risedronate Action Pathway, Rosuvastatin Action Pathway, SREBF and miR33 in cholesterol and lipid homeostasis, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Statin inhibition of cholesterol production, Steroid Biosynthesis, Sterol regulatory element-binding proteins (SREBP) signaling, Target Of Rapamycin (TOR) Signaling, Terpenoid backbone biosynthesis - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, mevalonate pathway, superpathway of cholesterol biosynthesis, superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
UniProt: P04035
Entrez ID: 3156
|
Does Knockout of IGF1R in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
IGF1R
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: IGF1R (insulin like growth factor 1 receptor)
Type: protein-coding
Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology: BP: amyloid-beta clearance, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to amyloid-beta, cellular response to glucose stimulus, cellular response to oxygen-containing compound, dendritic spine maintenance, immune response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, negative regulation of MAPK cascade, negative regulation of apoptotic process, peptidyl-tyrosine autophosphorylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of MAPK cascade, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein-containing complex disassembly, protein autophosphorylation, regulation of JNK cascade, signal transduction, transcytosis; MF: ATP binding, identical protein binding, insulin binding, insulin receptor activity, insulin receptor binding, insulin receptor substrate binding, insulin-like growth factor I binding, insulin-like growth factor binding, insulin-like growth factor receptor activity, kinase activity, nucleotide binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein transporter activity, protein tyrosine kinase activity, structural molecule activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: alphav-beta3 integrin-IGF-1-IGF1R complex, axon, cilium, insulin receptor complex, membrane, nucleolus, plasma membrane, protein kinase complex, receptor complex
Pathways: AMPK signaling pathway - Homo sapiens (human), Adherens junction - Homo sapiens (human), Apoptosis, Autophagy - animal - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Disease, EGFR Tyrosine Kinase Inhibitor Resistance, ESR-mediated signaling, Ebola Virus Pathway on Host, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Endocytosis - Homo sapiens (human), Extra-nuclear estrogen signaling, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), Glioblastoma signaling pathways, Glioma - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Head and Neck Squamous Cell Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, IGF1 pathway, IGF1R signaling cascade, IRS-related events triggered by IGF1R, Infectious disease, Insulin Signaling, Integrins in angiogenesis, Leptin, Long-term depression - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), MAPK signaling pathway - Homo sapiens (human), MECP2 and Associated Rett Syndrome, Melanoma - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Oocyte meiosis - Homo sapiens (human), Ovarian steroidogenesis - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Plasma membrane estrogen receptor signaling, Posttranslational regulation of adherens junction stability and dissassembly, Progesterone-mediated oocyte maturation - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, SHC-related events triggered by IGF1R, SHP2 signaling, Senescence and Autophagy in Cancer, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Somatroph axis (GH) and its relationship to dietary restriction and aging, Stabilization and expansion of the E-cadherin adherens junction, TSH, Thyroid stimulating hormone (TSH) signaling pathway, Transcriptional misregulation in cancer - Homo sapiens (human), Viral Infection Pathways, igf-1 signaling pathway, mTOR signaling pathway - Homo sapiens (human), multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation, regulation of bad phosphorylation, skeletal muscle hypertrophy is regulated via akt-mtor pathway, the igf-1 receptor and longevity
UniProt: P08069
Entrez ID: 3480
|
Does Knockout of LSM5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
LSM5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LSM5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: RNA splicing, mRNA catabolic process, mRNA processing, mRNA splicing, via spliceosome, response to bacterium; MF: RNA binding, protein binding, protein heterodimerization activity; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9Y4Y9
Entrez ID: 23658
|
Does Knockout of HSPA5 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
HSPA5
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HSPA5 (heat shock protein family A (Hsp70) member 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020].
Gene Ontology: BP: ER overload response, ERAD pathway, IRE1-mediated unfolded protein response, PERK-mediated unfolded protein response, cellular response to glucose starvation, cellular response to interleukin-4, cerebellar Purkinje cell layer development, cerebellum structural organization, endoplasmic reticulum unfolded protein response, maintenance of protein localization in endoplasmic reticulum, negative regulation of IRE1-mediated unfolded protein response, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of protein-containing complex assembly, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of cell migration, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, post-translational protein targeting to membrane, translocation, protein folding, protein folding in endoplasmic reticulum, protein refolding, proteolysis involved in protein catabolic process, regulation of ATF6-mediated unfolded protein response, regulation of IRE1-mediated unfolded protein response, regulation of PERK-mediated unfolded protein response, regulation of protein folding in endoplasmic reticulum, response to endoplasmic reticulum stress, substantia nigra development, translational initiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, cadherin binding, calcium ion binding, enzyme binding, heat shock protein binding, hydrolase activity, misfolded protein binding, nucleotide binding, protein binding, protein domain specific binding, protein folding chaperone, protein serine/threonine kinase inhibitor activity, protein-folding chaperone binding, ribosome binding, ubiquitin protein ligase binding, unfolded protein binding; CC: COP9 signalosome, cell surface, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, focal adhesion, intracellular membrane-bounded organelle, melanosome, membrane, midbody, mitochondrion, nucleus, plasma membrane, protein-containing complex
Pathways: ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, ATF6B (ATF6-beta) activates chaperones, Acetaminophen Metabolism Pathway, Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), AndrogenReceptor, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Homo sapiens (human), Apoptosis-related network due to altered Notch3 in ovarian cancer, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Etoposide Action Pathway, Etoposide Metabolism Pathway, Hemostasis, IRE1alpha activates chaperones, Ibuprofen Action Pathway, Ibuprofen Metabolism Pathway, Immune System, Interferon Signaling, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Lipid and atherosclerosis - Homo sapiens (human), Modulation of host responses by IFN-stimulated genes, Morphine Action Pathway, Morphine Metabolism Pathway, PERK regulates gene expression, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phenytoin (Antiarrhythmic) Action Pathway, Photodynamic therapy-induced unfolded protein response, Platelet activation, signaling and aggregation, Platelet degranulation , Prion disease - Homo sapiens (human), Prion disease pathway, Protein export - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of HSF1-mediated heat shock response, Response to elevated platelet cytosolic Ca2+, Retinol Metabolism, Sorafenib Metabolism Pathway, TSH, Thyroid hormone synthesis - Homo sapiens (human), Unfolded Protein Response (UPR), Unfolded protein response, Vitamin A Deficiency, prion pathway
UniProt: P11021
Entrez ID: 3309
|
Does Knockout of OSTC in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
OSTC
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: OSTC (oligosaccharyltransferase complex non-catalytic subunit)
Type: protein-coding
Summary: Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: dolichyl-diphosphooligosaccharide-protein glycotransferase activity, protein binding, protein-macromolecule adaptor activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Viral Infection Pathways
UniProt: Q9NRP0
Entrez ID: 58505
|
Does Knockout of RGPD6 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
RGPD6
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RGPD6 (RANBP2 like and GRIP domain containing 6)
Type: protein-coding
Summary: Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, protein binding; CC: cytoplasm, nuclear pore
Pathways:
UniProt: Q99666
Entrez ID: 729540
|
Does Knockout of USP36 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
USP36
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: USP36 (ubiquitin specific peptidase 36)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of macroautophagy, nucleolus organization, positive regulation of protein targeting to mitochondrion, protein deubiquitination, protein stabilization, proteolysis, regulation of apoptotic process, regulation of mitophagy, regulation of protein stability, regulation of rRNA processing; MF: K48-linked deubiquitinase activity, RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2B deubiquitinase activity, hydrolase activity, peptidase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9P275
Entrez ID: 57602
|
Does Knockout of CSTF3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
CSTF3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CSTF3 (cleavage stimulation factor subunit 3)
Type: protein-coding
Summary: The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA 3'-end processing, RNA processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA processing; MF: RNA binding, mRNA binding, protein binding; CC: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna
UniProt: Q12996
Entrez ID: 1479
|
Does Knockout of RGL1 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
RGL1
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: RGL1 (ral guanine nucleotide dissociation stimulator like 1)
Type: protein-coding
Summary: Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Ras protein signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cytosol, plasma membrane
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism, Metabolism of lipids, PPARA activates gene expression, RAF/MAP kinase cascade, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of lipid metabolism by PPARalpha, Signal Transduction
UniProt: Q9NZL6
Entrez ID: 23179
|
Does Knockout of ECHDC3 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,631
|
Knockout
|
ECHDC3
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: ECHDC3 (enoyl-CoA hydratase domain containing 3)
Type: protein-coding
Summary: Predicted to enable enoyl-CoA hydratase activity. Involved in positive regulation of cellular response to insulin stimulus. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process, positive regulation of cellular response to insulin stimulus; MF: enoyl-CoA hydratase activity, hydro-lyase activity; CC: mitochondrion
Pathways: Fatty Acid Biosynthesis
UniProt: Q96DC8
Entrez ID: 79746
|
Does Knockout of ST20-MTHFS in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
ST20-MTHFS
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ST20-MTHFS (ST20-MTHFS readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010].
Gene Ontology:
Pathways: One carbon pool by folate - Homo sapiens (human)
UniProt: A0A0A6YYL1
Entrez ID: 100528021
|
Does Knockout of TBC1D21 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TBC1D21
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TBC1D21 (TBC1 domain family member 21)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, flagellated sperm motility, plasma membrane to endosome transport, regulation of cilium assembly, sperm axoneme assembly, sperm mitochondrial sheath assembly, spermatogenesis; MF: GTPase activator activity, actin binding, protein binding, small GTPase binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, extracellular exosome, sperm midpiece
Pathways:
UniProt: Q8IYX1
Entrez ID: 161514
|
Does Knockout of USP53 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
USP53
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: USP53 (ubiquitin specific peptidase 53)
Type: protein-coding
Summary: Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in response to auditory stimulus and sensory perception of sound. Predicted to act upstream of or within action potential and neuron apoptotic process. Predicted to be located in bicellular tight junction. Predicted to be active in cell-cell junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: action potential, epithelial cell apoptotic process, neuron apoptotic process, outer hair cell apoptotic process, protein deubiquitination, response to auditory stimulus, sensory perception of sound; MF: K63-linked deubiquitinase activity, cysteine-type deubiquitinase activity, hydrolase activity, metal ion binding, protein binding; CC: anchoring junction, bicellular tight junction, cell-cell junction
Pathways:
UniProt: Q70EK8
Entrez ID: 54532
|
Does Knockout of FBXO42 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
FBXO42
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FBXO42 (F-box protein 42)
Type: protein-coding
Summary: Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010].
Gene Ontology: MF: protein binding, ubiquitin-like ligase-substrate adaptor activity
Pathways:
UniProt: Q6P3S6
Entrez ID: 54455
|
Does Knockout of PGBD4 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
PGBD4
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PGBD4 (piggyBac transposable element derived 4)
Type: protein-coding
Summary: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q96DM1
Entrez ID: 161779
|
Does Knockout of RPS28 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
RPS28
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPS28 (ribosomal protein S28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of SSU-rRNA, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, extracellular exosome, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62857
Entrez ID: 6234
|
Does Knockout of PNMA3 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
PNMA3
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: PNMA3 (PNMA family member 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Gene Ontology: MF: metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q9UL41
Entrez ID: 29944
|
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