prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Nae1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Nae1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Nae1 (NEDD8 activating enzyme E1 subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitotic DNA replication checkpoint signaling, neuron apoptotic process, protein neddylation, regulation of apoptotic process, regulation of neuron apoptotic process, regulation of postsynapse assembly; MF: NEDD8 activating enzyme activity, protein heterodimerization activity, ubiquitin protein ligase binding, ubiquitin-like modifier activating enzyme activity; CC: early endosome, glutamatergic synapse, membrane, plasma membrane, protein-containing complex
Pathways: Alzheimer disease - Mus musculus (mouse), Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8VBW6
Entrez ID: 234664
|
Does Knockout of Gm128 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Gm128
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm128 (predicted gene 128)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cell population proliferation; CC: cellular_component, extracellular region
Pathways:
UniProt: Q569E4
Entrez ID: 229588
|
Does Knockout of Mrps9 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Mrps9
|
cell proliferation
|
Regulatory T cell
|
Gene: Mrps9 (mitochondrial ribosomal protein S9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: intracellular organelle lumen, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D7N3
Entrez ID: 69527
|
Does Knockout of Fgf2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Fgf2
|
cell cycle progression
|
breast epithelium
|
Gene: Fgf2 (fibroblast growth factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, angiogenesis involved in coronary vascular morphogenesis, behavioral response to ethanol, branching involved in ureteric bud morphogenesis, cardiac muscle cell proliferation, cell differentiation, cell migration involved in sprouting angiogenesis, cellular response to mechanical stimulus, chondroblast differentiation, chromatin organization, corticotropin hormone secreting cell differentiation, embryo development ending in birth or egg hatching, fibroblast growth factor receptor signaling pathway, glial cell differentiation, growth factor dependent regulation of skeletal muscle satellite cell proliferation, hyaluronan catabolic process, lung development, lymphatic endothelial cell migration, mammary gland epithelial cell differentiation, negative regulation of blood vessel endothelial cell migration, negative regulation of cell population proliferation, negative regulation of fibroblast migration, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of stem cell proliferation, negative regulation of wound healing, neurogenesis, organ induction, paracrine signaling, positive chemotaxis, positive regulation of DNA biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of angiogenesis, positive regulation of blood vessel branching, positive regulation of blood vessel endothelial cell migration, positive regulation of canonical Wnt signaling pathway, positive regulation of cardiac muscle cell proliferation, positive regulation of cell division, positive regulation of cell fate specification, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell population proliferation, positive regulation of cerebellar granule cell precursor proliferation, positive regulation of endothelial cell chemotaxis, positive regulation of endothelial cell chemotaxis to fibroblast growth factor, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of epithelial tube formation, positive regulation of gene expression, positive regulation of inner ear auditory receptor cell differentiation, positive regulation of lens fiber cell differentiation, positive regulation of neuroblast proliferation, positive regulation of neuroepithelial cell differentiation, positive regulation of osteoblast differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein phosphorylation, positive regulation of smooth muscle cell proliferation, positive regulation of sprouting angiogenesis, positive regulation of stem cell differentiation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of vascular endothelial cell proliferation, regulation of cell cycle, regulation of cell migration, regulation of endothelial cell chemotaxis to fibroblast growth factor, regulation of retinal cell programmed cell death, release of sequestered calcium ion into cytosol, response to axon injury, response to ethanol, response to wortmannin, stem cell development, substantia nigra development, thyroid-stimulating hormone-secreting cell differentiation, wound healing; MF: chemoattractant activity, chemokine binding, cytokine activity, fibroblast growth factor receptor binding, growth factor activity, heparin binding, histone H3K9me2/3 reader activity, identical protein binding, integrin binding, protein binding, receptor-receptor interaction; CC: cytoplasm, extracellular region, extracellular space, nucleus
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, Extracellular matrix organization, FGFR1 ligand binding and activation, FGFR1b ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2b ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Non-integrin membrane-ECM interactions, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Syndecan interactions, TGFBR3 regulates FGF2 signaling
UniProt: P15655
Entrez ID: 14173
|
Does Knockout of Mien1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Mien1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mien1 (migration and invasion enhancer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, positive regulation of cell migration, positive regulation of filopodium assembly; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q9CQ86
Entrez ID: 103742
|
Does Knockout of Epc1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Epc1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Epc1 (enhancer of polycomb homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromatin organization, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, negative regulation of DNA-templated transcription, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of striated muscle cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process, regulation of cell cycle, regulation of chromatin organization, regulation of double-strand break repair, regulation of transcription by RNA polymerase II, sperm DNA condensation, spermatid development, spermatogenesis, vascular associated smooth muscle cell differentiation; MF: chromatin-protein adaptor activity, enzyme-substrate adaptor activity; CC: NuA4 histone acetyltransferase complex, cytoplasm, nuclear body, nuclear membrane, nucleolus, nucleoplasm, nucleosome, nucleus, piccolo histone acetyltransferase complex, site of double-strand break
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Transcriptional Regulation by E2F6
UniProt: Q8C9X6
Entrez ID: 13831
|
Does Knockout of Acadvl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Acadvl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Acadvl (acyl-Coenzyme A dehydrogenase, very long chain)
Type: protein-coding
Summary: This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: epithelial cell differentiation, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, negative regulation of fatty acid biosynthetic process, negative regulation of fatty acid oxidation, regulation of cholesterol metabolic process, response to cold, temperature homeostasis; MF: acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding, identical protein binding, long-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial nucleoid, mitochondrion, nucleolus, nucleoplasm
Pathways: Alcoholic liver disease - Mus musculus (mouse), Beta oxidation of palmitoyl-CoA to myristoyl-CoA, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, fatty acid β-oxidation I, mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: P50544
Entrez ID: 11370
|
Does Knockout of Slc7a11 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Slc7a11
|
cell cycle progression
|
breast epithelium
|
Gene: Slc7a11 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-cystine transport, L-glutamate import across plasma membrane, L-glutamate transmembrane transport, L-kynurenine transmembrane transport, adult behavior, amino acid transmembrane transport, amino acid transport, brain development, cellular response to oxidative stress, cellular response to stress, dipeptide import across plasma membrane, glutathione metabolic process, glutathione transmembrane transport, intracellular glutamate homeostasis, limb development, lung alveolus development, lysosomal lumen pH elevation, modulation of chemical synaptic transmission, negative regulation of ferroptosis, platelet aggregation, proton transmembrane transport, regulation of AMPA glutamate receptor clustering, regulation of cell population proliferation, regulation of cellular response to oxidative stress, regulation of cysteine metabolic process, regulation of glutamate metabolic process, regulation of glutathione biosynthetic process, regulation of melanin biosynthetic process, regulation of neutrophil apoptotic process, regulation of programmed cell death, regulation of protein transport, regulation of synapse organization, response to redox state, response to toxic substance, striatum development, transmembrane transport, ventricular system development, visual learning; MF: L-amino acid transmembrane transporter activity, L-kynurenine transmembrane transporter activity, cystine:glutamate antiporter activity, leak channel activity, proton channel activity, transmembrane transporter activity; CC: apical part of cell, astrocyte projection, brush border membrane, cell projection, cell surface, lysosomal membrane, membrane, microvillus membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Ferroptosis - Mus musculus (mouse), Hemostasis, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q9WTR6
Entrez ID: 26570
|
Does Knockout of Mettl21c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Mettl21c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mettl21c (methyltransferase 21C, AARS1 lysine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dexamethasone stimulus, hormone-mediated apoptotic signaling pathway, methylation, protein methylation, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, skeletal muscle tissue development; MF: heat shock protein binding, methyltransferase activity, protein methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q8BLU2
Entrez ID: 433294
|
Does Knockout of Adgrf5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Adgrf5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adgrf5 (adhesion G protein-coupled receptor F5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, energy reserve metabolic process, erythrocyte development, fat cell differentiation, glomerular filtration, glucose homeostasis, negative regulation of macrophage activation, pharyngeal arch artery morphogenesis, positive regulation of phospholipid biosynthetic process, regulation of lipid metabolic process, surfactant homeostasis; MF: G protein-coupled receptor activity, molecular_function, transmembrane signaling receptor activity; CC: apical part of cell, cell surface, cytoplasmic vesicle, membrane, plasma membrane
Pathways: Metabolism of proteins, Surfactant metabolism
UniProt: G5E8Q8
Entrez ID: 224792
|
Does Knockout of Dbr1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Dbr1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dbr1 (debranching RNA lariats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA fragment catabolic process, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: RNA lariat debranching enzyme activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q923B1
Entrez ID: 83703
|
Does Knockout of Ttc36 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ttc36
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ttc36 (tetratricopeptide repeat domain 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system neuron development, memory, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein polyubiquitination, tyrosine metabolic process, visual learning
Pathways:
UniProt: Q8VBW8
Entrez ID: 192653
|
Does Knockout of Uri1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Uri1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Uri1 (URI1, prefoldin-like chaperone)
Type: protein-coding
Summary: Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Is expressed in several structures, including alimentary system; brain; epithelium; genitourinary system; and muscle tissue. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to growth factor stimulus, cellular response to steroid hormone stimulus, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of phosphatase activity, negative regulation of transcription by RNA polymerase II, regulation of cell growth, regulation of transcription by RNA polymerase II, response to virus; MF: RNA polymerase II complex binding, chromatin binding, phosphatase inhibitor activity, phosphoprotein binding, protein phosphatase inhibitor activity, transcription corepressor activity; CC: RPAP3/R2TP/prefoldin-like complex, cell projection, cytoplasm, cytosol, dendrite, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q3TLD5
Entrez ID: 19777
|
Does Knockout of Dgcr2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Dgcr2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dgcr2 (DiGeorge syndrome critical region gene 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cognition, response to xenobiotic stimulus; CC: membrane
Pathways:
UniProt: P98154
Entrez ID: 13356
|
Does Knockout of Nkg7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Nkg7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nkg7 (natural killer cell group 7 sequence)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell activation, defense response to protozoan, granzyme-mediated programmed cell death signaling pathway, inflammatory response, killing of cells of another organism, natural killer cell degranulation, natural killer cell mediated cytotoxicity, natural killer cell mediated cytotoxicity directed against tumor cell target, positive regulation of inflammatory response; CC: cytolytic granule, cytolytic granule membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q8C2L9, Q9CY55
Entrez ID: 72310
|
Does Knockout of Rnf19b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rnf19b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rnf19b (ring finger protein 19B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, natural killer cell mediated cytotoxicity, protein autoubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytolytic granule, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: A2A7Q9
Entrez ID: 75234
|
Does Knockout of Cul9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Cul9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cul9 (cullin 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, protein ubiquitination, regulation of mitotic nuclear division, ubiquitin-dependent protein catabolic process; MF: ATP binding, metal ion binding, nucleotide binding, transferase activity, ubiquitin protein ligase binding, zinc ion binding; CC: cullin-RING ubiquitin ligase complex, cytoplasm, cytosol
Pathways:
UniProt: Q80TT8
Entrez ID: 78309
|
Does Knockout of Spint2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Spint2
|
cell proliferation
|
Regulatory T cell
|
Gene: Spint2 (serine protease inhibitor, Kunitz type 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basement membrane organization, epithelial cell morphogenesis involved in placental branching, establishment or maintenance of cell polarity, negative regulation of cell motility, negative regulation of cell-cell adhesion, negative regulation of neural precursor cell proliferation, neural tube closure; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, cytoplasm, membrane, plasma membrane
Pathways: MET Receptor Activation, Signal Transduction, Signaling by MET, Signaling by MST1, Signaling by Receptor Tyrosine Kinases
UniProt: Q9WU03
Entrez ID: 20733
|
Does Knockout of Slx1b in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,532
|
Knockout
|
Slx1b
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Slx1b (SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, positive regulation of t-circle formation, regulation of telomere maintenance, t-circle formation; MF: 5'-flap endonuclease activity, crossover junction DNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, zinc ion binding; CC: Slx1-Slx4 complex, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q8BX32
Entrez ID: 75764
|
Does Knockout of Ctdsp1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ctdsp1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ctdsp1 (CTD small phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of G1/S transition of mitotic cell cycle, negative regulation of neurogenesis, negative regulation of neuron differentiation, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, hydrolase activity, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: P58466
Entrez ID: 227292
|
Does Knockout of Tubb2a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tubb2a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tubb2a (tubulin, beta 2A class IIA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebral cortex development, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle, neuron migration; MF: GTP binding, GTPase activity, metal ion binding, nucleotide binding, structural constituent of cytoskeleton; CC: cytoplasm, cytoskeleton, intercellular bridge, microtubule, microtubule cytoskeleton, mitotic spindle
Pathways: Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q7TMM9
Entrez ID: 22151
|
Does Activation of Idnk in Mouse cell causally result in protein/peptide accumulation?
| 1
| 690
|
Activation
|
Idnk
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Idnk (idnK gluconokinase homolog (E. coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, gluconokinase activity, kinase activity, nucleotide binding, transferase activity
Pathways: Pentose phosphate pathway - Mus musculus (mouse)
UniProt: Q8R0J8
Entrez ID: 75731
|
Does Knockout of Tor1b in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Tor1b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tor1b (torsin family 1, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum organization, nuclear membrane organization, protein localization to nucleus; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, identical protein binding, kinesin binding, nucleotide binding, protein binding; CC: cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum lumen, membrane, nuclear envelope, nuclear membrane, nucleus
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9ER41
Entrez ID: 30934
|
Does Knockout of Arhgap29 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Arhgap29
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Arhgap29 (Rho GTPase activating protein 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of small GTPase mediated signal transduction, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity, PDZ domain binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8CGF1
Entrez ID: 214137
|
Does Knockout of Stub1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,158
|
Knockout
|
Stub1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Stub1 (STIP1 homology and U-Box containing protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, ERAD pathway, MAPK cascade, cellular response to heat, cellular response to hypoxia, cellular response to misfolded protein, chaperone-mediated autophagy, endoplasmic reticulum unfolded protein response, negative regulation of apoptotic process, negative regulation of cardiac muscle hypertrophy, negative regulation of peroxisome proliferator activated receptor signaling pathway, negative regulation of smooth muscle cell apoptotic process, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of vascular associated smooth muscle contraction, positive regulation of ERAD pathway, positive regulation of chaperone-mediated protein complex assembly, positive regulation of metabolic process, positive regulation of mitophagy, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, positive regulation of proteolysis, positive regulation of smooth muscle cell apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein autoubiquitination, protein folding, protein monoubiquitination, protein polyubiquitination, protein quality control for misfolded or incompletely synthesized proteins, protein stabilization, protein ubiquitination, regulation of glucocorticoid metabolic process, regulation of protein stability, response to ischemia, signal transduction, ubiquitin-dependent protein catabolic process; MF: G protein-coupled receptor binding, Hsp70 protein binding, Hsp90 protein binding, R-SMAD binding, SMAD binding, TPR domain binding, enzyme binding, heat shock protein binding, kinase binding, misfolded protein binding, protein binding, protein homodimerization activity, protein-folding chaperone binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: Z disc, cytoplasm, cytosol, endoplasmic reticulum, mitochondrion, nuclear inclusion body, nucleoplasm, nucleus, protein folding chaperone complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Death Receptor Signaling, Downregulation of ERBB2 signaling, Downregulation of TGF-beta receptor signaling, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, Programmed Cell Death, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, Regulated Necrosis, Regulation of PTEN stability and activity, Regulation of RUNX2 expression and activity, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNF signaling, Transcriptional regulation by RUNX2, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9WUD1
Entrez ID: 56424
|
Does Knockout of Fndc1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Fndc1
|
cell cycle progression
|
breast epithelium
|
Gene: Fndc1 (fibronectin type III domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, positive regulation of cardiac muscle cell apoptotic process, regulation of protein transport; CC: cell-cell junction, cytoplasm, extracellular region, mitochondrial membrane, plasma membrane
Pathways:
UniProt: A0A6I8MWX0, A0A8V5KYN9, E9Q043, E9Q8V0
Entrez ID: 68655
|
Does Knockout of Mcm6 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mcm6
|
cell cycle progression
|
breast epithelium
|
Gene: Mcm6 (minichromosome maintenance complex component 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication, premeiotic DNA replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, single-stranded 3'-5' DNA helicase activity, single-stranded DNA binding; CC: CMG complex, MCM complex, chromosome, cytosol, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: P97311
Entrez ID: 17219
|
Does Knockout of Prkra in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Prkra
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Prkra (protein kinase, interferon inducible double stranded RNA dependent activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, antiviral innate immune response, cellular response to oxidative stress, ear development, miRNA processing, middle ear morphogenesis, outer ear morphogenesis, positive regulation of cell population proliferation, positive regulation of intrinsic apoptotic signaling pathway, pre-miRNA processing, protein stabilization, regulation of regulatory ncRNA processing, regulatory ncRNA-mediated gene silencing, siRNA processing, skeletal system morphogenesis; MF: RNA binding, double-stranded RNA binding, enzyme binding, identical protein binding, pre-miRNA binding, protein binding, protein homodimerization activity, protein kinase activator activity, protein kinase binding, siRNA binding; CC: RISC complex, RISC-loading complex, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Gene Silencing by RNA, Gene expression (Transcription), Immune System, Interferon Signaling, MicroRNA (miRNA) biogenesis, PKR-mediated signaling, Small interfering RNA (siRNA) biogenesis
UniProt: Q9WTX2
Entrez ID: 23992
|
Does Knockout of Scn10a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Scn10a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Scn10a (sodium channel, voltage-gated, type X, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AV node cell action potential, behavioral response to pain, bundle of His cell action potential, cardiac conduction, circadian rhythm, detection of mechanical stimulus involved in sensory perception, detection of temperature stimulus involved in sensory perception of pain, establishment of localization in cell, membrane depolarization during action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, regulation of atrial cardiac muscle cell membrane depolarization, regulation of cardiac muscle contraction, regulation of heart rate, regulation of membrane potential, regulation of monoatomic ion transmembrane transport, sensory perception of pain, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: monoatomic cation channel activity, monoatomic ion channel activity, sodium channel activity, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated sodium channel activity, voltage-gated sodium channel activity involved in cardiac muscle cell action potential; CC: C-fiber, axon, clathrin complex, glutamatergic synapse, membrane, monoatomic ion channel complex, plasma membrane, presynaptic membrane, voltage-gated sodium channel complex
Pathways:
UniProt: Q6QIY3
Entrez ID: 20264
|
Does Knockout of Tmbim6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Tmbim6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmbim6 (transmembrane BAX inhibitor motif containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRE1-mediated unfolded protein response, apoptotic process, autophagy, calcium ion transmembrane transport, cellular response to unfolded protein, endoplasmic reticulum calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of IRE1-mediated unfolded protein response, negative regulation of RNA splicing, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, negative regulation of calcium ion transport into cytosol, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of immunoglobulin production, negative regulation of transcription by RNA polymerase II, neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, response to L-glutamate, response to endoplasmic reticulum stress, response to unfolded protein; MF: calcium channel activity, endoribonuclease inhibitor activity, enzyme binding, ubiquitin protein ligase binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9D2C7
Entrez ID: 110213
|
Does Knockout of Top1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Top1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Top1 (topoisomerase (DNA) I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q04750
Entrez ID: 21969
|
Does Knockout of Ephx3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ephx3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ephx3 (epoxide hydrolase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxide metabolic process, lipid metabolic process; MF: catalytic activity, epoxide hydrolase activity, hydrolase activity; CC: endoplasmic reticulum, intracellular membrane-bounded organelle, membrane
Pathways: Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse)
UniProt: Q3V1F8
Entrez ID: 71932
|
Does Knockout of Dnajb1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Dnajb1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dnajb1 (DnaJ heat shock protein family (Hsp40) member B1)
Type: protein-coding
Summary: This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cellular response to heat, negative regulation of inclusion body assembly, negative regulation of transcription by RNA polymerase II, positive regulation of protein folding, protein folding; MF: ATPase activator activity, ATPase binding, Hsp70 protein binding, protein folding chaperone, protein-folding chaperone binding, transcription corepressor activity, transcription regulator inhibitor activity, unfolded protein binding; CC: cytoplasm, cytosol, dendritic spine, glutamatergic synapse, neuronal cell body, nucleolus, nucleoplasm, nucleus, postsynapse, postsynaptic density, sperm head
Pathways: Attenuation phase, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Influenza A - Mus musculus (mouse), MAPK family signaling cascades, MAPK6/MAPK4 signaling, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response, Signal Transduction
UniProt: Q9QYJ3
Entrez ID: 81489
|
Does Knockout of Pla2g4f in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Pla2g4f
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pla2g4f (phospholipase A2, group IVF)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate secretion, cellular response to antibiotic, fatty acid transport, glycerophospholipid catabolic process, lipid catabolic process, lipid metabolic process, phospholipid catabolic process, prostaglandin biosynthetic process; MF: calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, hydrolase activity, metal ion binding, phosphatidylcholine lysophospholipase activity, phospholipase A2 activity, phospholipase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, plasma membrane, ruffle membrane, vesicle
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hydrolysis of LPC, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Necroptosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: Q50L41
Entrez ID: 271844
|
Does Knockout of Fxn in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Fxn
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fxn (frataxin)
Type: protein-coding
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in [4Fe-4S] cluster assembly. Acts upstream of or within several processes, including adult walking behavior; muscle cell cellular homeostasis; and negative regulation of organ growth. Located in mitochondrion. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; glioblastoma; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, adult walking behavior, aerobic respiration, cellular response to hydrogen peroxide, embryo development ending in birth or egg hatching, heme biosynthetic process, inorganic ion homeostasis, intracellular iron ion homeostasis, intracellular monoatomic cation homeostasis, iron import into the mitochondrion, iron ion transport, iron-sulfur cluster assembly, mitochondrion organization, monoatomic ion transport, muscle cell cellular homeostasis, negative regulation of apoptotic process, negative regulation of lipid storage, negative regulation of multicellular organism growth, negative regulation of neuron apoptotic process, negative regulation of organ growth, negative regulation of release of cytochrome c from mitochondria, oxidative phosphorylation, positive regulation of axon extension, positive regulation of mitochondrial membrane permeability, proprioception, protein autoprocessing, protein maturation, regulation of cytosolic calcium ion concentration, regulation of growth, response to iron ion; MF: 2 iron, 2 sulfur cluster binding, enzyme activator activity, enzyme binding, ferric iron binding, ferrous iron binding, ferroxidase activity, iron chaperone activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Protein localization, Respiratory electron transport
UniProt: O35943
Entrez ID: 14297
|
Does Knockout of Il1f10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Il1f10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Il1f10 (interleukin 1 family, member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, cytokine-mediated signaling pathway, immune response, inflammatory response; MF: cytokine activity, interleukin-1 receptor binding; CC: cytoplasm, endoplasmic reticulum-Golgi intermediate compartment, extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-36 pathway, Interleukin-38 signaling, Signaling by Interleukins
UniProt: Q8R459
Entrez ID: 215274
|
Does Knockout of Cyp2j12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cyp2j12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cyp2j12 (cytochrome P450, family 2, subfamily j, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, icosanoid metabolic process, linoleic acid metabolic process, organic acid metabolic process, xenobiotic metabolic process; MF: arachidonate 11,12-epoxygenase activity, arachidonate 14,15-epoxygenase activity, arachidonate epoxygenase activity, heme binding, iron ion binding, isomerase activity, linoleic acid epoxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse)
UniProt: G3UZ89, G3UXT0
Entrez ID: 242546
|
Does Knockout of Nup133 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nup133
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nup133 (nucleoporin 133)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, mRNA export from nucleus, mRNA transport, nephron development, neural tube development, neurogenesis, nuclear pore organization, nucleocytoplasmic transport, paraxial mesoderm development, poly(A)+ mRNA export from nucleus, protein import into nucleus, protein transport, somite development, system development, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: structural constituent of nuclear pore; CC: chromosome, chromosome, centromeric region, kinetochore, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8R0G9
Entrez ID: 234865
|
Does Knockout of Pyroxd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Pyroxd1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pyroxd1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress; MF: NAD(P)H oxidase H2O2-forming activity, molecular_function, oxidoreductase activity; CC: cytoplasm, nucleus, sarcomere
Pathways:
UniProt: Q3TMV7
Entrez ID: 232491
|
Does Knockout of Ercc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ercc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, UV protection, apoptotic process, bone mineralization, central nervous system myelin formation, chromosome segregation, determination of adult lifespan, embryonic cleavage, embryonic organ development, erythrocyte maturation, extracellular matrix organization, hair cell differentiation, hair cycle process, hair follicle maturation, hematopoietic stem cell differentiation, hematopoietic stem cell proliferation, in utero embryonic development, insulin-like growth factor receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), multicellular organism growth, nucleobase-containing compound metabolic process, nucleotide-excision repair, positive regulation of mitotic recombination, post-embryonic development, regulation of mitotic cell cycle phase transition, regulation of transcription by RNA polymerase II, response to UV, response to hypoxia, response to oxidative stress, ribosomal small subunit biogenesis, skin development, spinal cord development, transcription by RNA polymerase II, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase II promoter, transcription-coupled nucleotide-excision repair; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, damaged DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein-macromolecule adaptor activity; CC: CAK-ERCC2 complex, MMXD complex, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, spindle, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping
UniProt: O08811
Entrez ID: 13871
|
Does Knockout of Tomm5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Tomm5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tomm5 (translocase of outer mitochondrial membrane 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein targeting to mitochondrion, protein transport; CC: membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: B1AXP6
Entrez ID: 68512
|
Does Knockout of Exosc8 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Exosc8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Exosc8 (exosome component 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nuclear mRNA surveillance, nuclear polyadenylation-dependent rRNA catabolic process, rRNA catabolic process, rRNA processing; MF: RNA binding, identical protein binding, mRNA 3'-UTR AU-rich region binding, protein binding; CC: chromosome, cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), fibrillar center, nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D753
Entrez ID: 69639
|
Does Knockout of Timm8a1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Timm8a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Timm8a1 (translocase of inner mitochondrial membrane 8A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport; MF: identical protein binding, metal ion binding, zinc ion binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways:
UniProt: Q9WVA2
Entrez ID: 30058
|
Does Knockout of Acin1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Acin1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Acin1 (apoptotic chromatin condensation inducer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic chromosome condensation, apoptotic process, erythrocyte differentiation, mRNA processing, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, positive regulation of monocyte differentiation; CC: ASAP complex, cytosol, exon-exon junction complex, nuclear lumen, nuclear speck, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9JIX8
Entrez ID: 56215
|
Does Knockout of Phldb1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Phldb1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Phldb1 (pleckstrin homology like domain, family B, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: basal cortex
Pathways:
UniProt: Q6PDH0
Entrez ID: 102693
|
Does Knockout of Fam83g in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Fam83g
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fam83g (family with sequence similarity 83, member G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5SWY7
Entrez ID: 69640
|
Does Knockout of Trmt61a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Trmt61a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trmt61a (tRNA methyltransferase 61A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, mRNA processing, methylation, tRNA methylation, tRNA processing; MF: mRNA (adenine-N1-)-methyltransferase activity, methyltransferase activity, tRNA (adenine(58)-N1)-methyltransferase activity, transferase activity; CC: nucleus, tRNA (m1A) methyltransferase complex
Pathways:
UniProt: Q80XC2
Entrez ID: 328162
|
Does Knockout of C1qtnf4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
C1qtnf4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: C1qtnf4 (C1q and tumor necrosis factor related protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via STAT, gene expression, positive regulation of interleukin-6 production, positive regulation of interleukin-6-mediated signaling pathway, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of tumor necrosis factor production, reduction of food intake in response to dietary excess; MF: cytokine activity, molecular_function; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8R066
Entrez ID: 67445
|
Does Knockout of Emc10 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Emc10
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Emc10 (ER membrane protein complex subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, positive regulation of angiogenesis, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, membrane
Pathways:
UniProt: Q3TAS6
Entrez ID: 69683
|
Does Knockout of Map3k14 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Map3k14
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, cellular response to mechanical stimulus, defense response to virus, immune response, non-canonical NF-kappaB signal transduction; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, fibrillar center, nucleoplasm
Pathways: Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD28 dependent PI3K/Akt signaling, CLEC7A (Dectin-1) signaling, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Co-stimulation by CD28, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Epstein-Barr virus infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NIK-->noncanonical NF-kB signaling, Osteoclast differentiation - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway
UniProt: Q9WUL6
Entrez ID: 53859
|
Does Knockout of Vps29 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Vps29
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Vps29 (VPS29 retromer complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to vacuole transport, endocytic recycling, intracellular protein transport, protein transport, retrograde transport, endosome to Golgi; MF: metal ion binding, protein binding; CC: cytoplasm, cytosol, endosome, endosome membrane, membrane, retromer complex, retromer, cargo-selective complex
Pathways: Endocytosis - Mus musculus (mouse), Signal Transduction, Signaling by WNT, WNT ligand biogenesis and trafficking, serine biosynthesis, superpathway of serine and glycine biosynthesis I
UniProt: Q9QZ88
Entrez ID: 56433
|
Does Knockout of Tnr in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Tnr
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tnr (tenascin R)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, axon regeneration, cell adhesion, extracellular matrix organization, locomotory exploration behavior, long-term synaptic potentiation, modulation of chemical synaptic transmission, negative regulation of axon extension, negative regulation of axon extension involved in regeneration, negative regulation of cell adhesion, negative regulation of cell-cell adhesion, negative regulation of neuron projection development, negative regulation of synaptic transmission, nervous system development, neuroblast migration, neuromuscular process controlling balance, neuron cell-cell adhesion, positive regulation of synaptic transmission, glutamatergic, positive regulation of transmission of nerve impulse, regulation of cell adhesion, regulation of cell differentiation, regulation of cell migration, synapse organization, telencephalon cell migration; MF: integrin binding, sphingolipid binding; CC: Schaffer collateral - CA1 synapse, cell surface, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane raft, perineuronal net, perisynaptic extracellular matrix, tenascin complex
Pathways: ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse)
UniProt: Q8BYI9
Entrez ID: 21960
|
Does Knockout of Cenpp in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Cenpp
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cenpp (centromere protein P)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, biological_process, chromosome segregation; CC: chromosome, chromosome, centromeric region, inner kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CZ92
Entrez ID: 66336
|
Does Knockout of Slc30a9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Slc30a9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Slc30a9 (solute carrier family 30 (zinc transporter), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transport, positive regulation of transcription by RNA polymerase II, regulation of mitochondrion organization, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: antiporter activity, chromatin binding, monoatomic cation transmembrane transporter activity, nuclear receptor binding, transcription coactivator activity, zinc ion transmembrane transporter activity; CC: cytoplasm, cytoplasmic vesicle, cytoskeleton, endoplasmic reticulum, membrane, mitochondrial membrane, mitochondrion, nucleus
Pathways:
UniProt: Q5IRJ6
Entrez ID: 109108
|
Does Knockout of Nat10 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Nat10
|
response to virus
|
Microglial Cell Line
|
Gene: Nat10 (N-acetyltransferase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, negative regulation of telomere maintenance via telomerase, positive regulation of translation, protein acetylation, rRNA acetylation involved in maturation of SSU-rRNA, rRNA metabolic process, rRNA modification, rRNA processing, regulation of centrosome duplication, regulation of translation, ribosomal small subunit biogenesis, ribosome biogenesis, tRNA acetylation, tRNA processing, tRNA wobble cytosine modification; MF: 18S rRNA cytidine N-acetyltransferase activity, ATP binding, DNA polymerase binding, N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, mRNA N-acetyltransferase activity, nucleotide binding, tRNA binding, tRNA cytidine N4-acetyltransferase activity, transferase activity; CC: midbody, nucleolus, nucleus, small-subunit processome, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q8K224
Entrez ID: 98956
|
Does Knockout of Rps15a in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rps15a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rps15a (ribosomal protein S15A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell cycle, positive regulation of cell population proliferation, response to virus, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62245
Entrez ID: 267019
|
Does Knockout of A130010J15Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
A130010J15Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: A130010J15Rik (RIKEN cDNA A130010J15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAE8
Entrez ID: 319266
|
Does Knockout of Limk2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Limk2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Limk2 (LIM domain kinase 2)
Type: protein-coding
Summary: Enables protein kinase activity. Acts upstream of or within several processes, including cornea development in camera-type eye; protein phosphorylation; and spermatogenesis. Located in cis-Golgi network and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin cytoskeleton organization, astral microtubule organization, cornea development in camera-type eye, establishment of vesicle localization, head development, negative regulation of cilium assembly, positive regulation of protein localization to nucleus, protein phosphorylation, spermatogenesis; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, cis-Golgi network, cytoplasm, cytoskeleton, mitotic spindle, nucleus, perinuclear region of cytoplasm, spindle
Pathways: Axon guidance - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: O54785
Entrez ID: 16886
|
Does Knockout of Zfp318 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Zfp318
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Zfp318 (zinc finger protein 318)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription; MF: metal ion binding, nucleic acid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q99PP2
Entrez ID: 57908
|
Does Knockout of Tubgcp5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Tubgcp5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tubgcp5 (tubulin, gamma complex component 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule binding, microtubule minus-end binding; CC: centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, spindle pole
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q8BKN5
Entrez ID: 233276
|
Does Knockout of Ctsg in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ctsg
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ctsg (cathepsin G)
Type: protein-coding
Summary: This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: antibacterial humoral response, biofilm matrix disassembly, cellular response to lipopolysaccharide, chemotaxis, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, defense response to fungus, monocyte chemotaxis, negative regulation of T cell activation, neutrophil activation, neutrophil-mediated killing of gram-positive bacterium, platelet activation, positive regulation of immune response, positive regulation of platelet aggregation, protein maturation, protein processing, proteolysis, response to lipopolysaccharide, signal transduction; MF: caspase binding, heparin binding, hydrolase activity, peptidase activity, protein binding, receptor ligand activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, extracellular region, extracellular space, lysosome, membrane, nucleus, plasma membrane, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Amoebiasis - Mus musculus (mouse), Antimicrobial peptides, Cytokine Signaling in Immune system, Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 processing, Lysosome - Mus musculus (mouse), Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Peptide hormone metabolism, Renin-angiotensin system - Mus musculus (mouse), Signaling by Interleukins, Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: P28293
Entrez ID: 13035
|
Does Knockout of Actr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Actr2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Actr2 (actin related protein 2)
Type: protein-coding
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; meiotic chromosome movement towards spindle pole; and meiotic cytokinesis. Located in actin cap. Is expressed in cochlea and metanephros. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin cytoskeleton organization, asymmetric cell division, cellular response to type II interferon, cilium assembly, cytosolic transport, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of dendritic spine morphogenesis, positive regulation of double-strand break repair via homologous recombination, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of double-strand break repair via nonhomologous end joining, spindle localization; MF: ATP binding, actin binding, actin filament binding, cytoskeletal protein binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cap, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, lamellipodium, nucleus, podosome core, postsynapse, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: P61161
Entrez ID: 66713
|
Does Knockout of Cfap77 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Cfap77
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cfap77 (cilia and flagella associated protein 77)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, flagellated sperm motility; CC: axonemal B tubule inner sheath, axonemal microtubule, axoneme, cell projection, cellular_component, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: A0A087WRI3
Entrez ID: 329375
|
Does Knockout of Slco2b1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Slco2b1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Slco2b1 (solute carrier organic anion transporter family, member 2b1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, cell population proliferation, cellular response to iron ion starvation, heme import into cell, intercellular transport, intracellular iron ion homeostasis, monoatomic ion transport, organic anion transport, sodium-independent icosanoid transport, sodium-independent organic anion transport, transmembrane transport, xenobiotic transport; MF: bile acid transmembrane transporter activity, organic anion transmembrane transporter activity, prostaglandin transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, transmembrane transporter activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: Aspirin ADME, Atorvastatin ADME, Drug ADME, Heme degradation, Metabolism, Metabolism of porphyrins, Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q8BXB6
Entrez ID: 101488
|
Does Knockout of Rpl22 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rpl22
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rpl22 (ribosomal protein L22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-beta T cell differentiation, cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, heparin binding, identical protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, glutamatergic synapse, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P67984
Entrez ID: 19934
|
Does Knockout of Cdca5 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,549
|
Knockout
|
Cdca5
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Cdca5 (cell division cycle associated 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, double-strand break repair, mitotic sister chromatid cohesion; MF: protein binding, protein-containing complex binding; CC: chromatin, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, M Phase, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Resolution of Sister Chromatid Cohesion, S Phase, Separation of Sister Chromatids
UniProt: Q9CPY3
Entrez ID: 67849
|
Does Knockout of Lrrc34 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Lrrc34
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Lrrc34 (leucine rich repeat containing 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, gene expression, telomere maintenance; CC: cellular_component, cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q9DAM1
Entrez ID: 71827
|
Does Knockout of Thop1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Thop1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Thop1 (thimet oligopeptidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, peptide catabolic process, peptide metabolic process, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, peptide binding; CC: cytoplasm, mitochondrial intermembrane space
Pathways: Adaptive Immune System, African trypanosomiasis - Mus musculus (mouse), Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q8C1A5
Entrez ID: 50492
|
Does Knockout of Nhlh2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Nhlh2
|
cell proliferation
|
Regulatory T cell
|
Gene: Nhlh2 (nescient helix loop helix 2)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Acts upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Located in chromatin. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; head mesenchyme derived from neural crest; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NHLH2 (nescient helix-loop-helix 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, cell differentiation, cell migration in hindbrain, central nervous system development, hypothalamus gonadotrophin-releasing hormone neuron development, male gonad development, male mating behavior, ovulation cycle, peripheral nervous system development, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding, transcription coactivator binding; CC: chromatin, nucleus
Pathways:
UniProt: Q64221
Entrez ID: 18072
|
Does Knockout of Sf3b6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Sf3b6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sf3b6 (splicing factor 3B, subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding; CC: U12-type spliceosomal complex, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: P59708
Entrez ID: 66055
|
Does Knockout of Gbp2b in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Gbp2b
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gbp2b (guanylate binding protein 2b)
Type: protein-coding
Summary: Enables GMP binding activity and GTPase activity. Involved in cytolysis in another organism; positive regulation of defense response; and response to bacterium. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: activation of innate immune response, adhesion of symbiont to host, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cytolysis in another organism, defense response to Gram-positive bacterium, defense response to bacterium, defense response to protozoan, defense response to virus, immune system process, innate immune response, non-canonical inflammasome complex assembly, positive regulation of pyroptotic inflammatory response, regulation of defense response; MF: G protein activity, GDP binding, GDP phosphatase activity, GMP binding, GTP binding, GTPase activity, Hsp90 protein binding, actin binding, cytokine binding, endopeptidase inhibitor activity, enzyme binding, hydrolase activity, identical protein binding, lipopolysaccharide binding, molecular function inhibitor activity, nucleotide binding, protein binding, protein homodimerization activity, spectrin binding; CC: Golgi apparatus, Golgi membrane, actin cytoskeleton, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, extracellular region, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, symbiont cell surface, symbiont-containing vacuole membrane, vesicle membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: A4UUI2
Entrez ID: 14468
|
Does Knockout of Znhit6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Znhit6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Znhit6 (zinc finger, HIT type 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box C/D snoRNP assembly, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), protein complex oligomerization, ribosome biogenesis, snoRNA localization; MF: ATPase binding, TFIID-class transcription factor complex binding, enzyme binding, identical protein binding, metal ion binding, zinc ion binding; CC: nucleus, pre-snoRNP complex
Pathways:
UniProt: Q3UFB2
Entrez ID: 229937
|
Does Knockout of Lage3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Lage3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lage3 (L antigen family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA threonylcarbamoyladenosine metabolic process; CC: EKC/KEOPS complex, cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q9CR70
Entrez ID: 66192
|
Does Knockout of Tnfrsf10b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tnfrsf10b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tnfrsf10b (tumor necrosis factor receptor superfamily, member 10b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TRAIL-activated apoptotic signaling pathway, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of multicellular organismal process, positive regulation of apoptotic process, regulation of apoptotic process, response to endoplasmic reticulum stress, signal transduction; MF: TRAIL binding, TRAIL receptor activity, cysteine-type endopeptidase activator activity involved in apoptotic process, identical protein binding, protease binding, transmembrane signaling receptor activity; CC: Golgi apparatus, cell surface, cytosol, membrane, membrane raft, plasma membrane, plasma membrane raft
Pathways: Apoptosis - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9QZM4
Entrez ID: 21933
|
Does Knockout of Brix1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Brix1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Brix1 (BRX1, biogenesis of ribosomes)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal large subunit assembly, ribosome biogenesis; MF: RNA binding, rRNA binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q9DCA5
Entrez ID: 67832
|
Does Knockout of Ears2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ears2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ears2 (glutamyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015].
Gene Ontology: BP: glutamyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for mitochondrial protein translation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, glutamate-tRNA ligase activity, glutamate-tRNA(Gln) ligase activity, ligase activity, nucleotide binding, tRNA binding, zinc ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CXJ1
Entrez ID: 67417
|
Does Knockout of Slc25a3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Slc25a3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc25a3 (solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial phosphate ion transmembrane transport, phosphate ion transmembrane transport, proton transmembrane transport; MF: phosphate transmembrane transporter activity, phosphate:proton symporter activity, protein-containing complex binding, symporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion, myelin sheath
Pathways:
UniProt: Q8VEM8
Entrez ID: 18674
|
Does Knockout of Abcb7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Abcb7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Abcb7 (ATP-binding cassette, sub-family B member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular iron ion homeostasis, iron ion transmembrane transport, iron-sulfur cluster assembly, iron-sulfur cluster export from the mitochondrion, negative regulation of reactive oxygen species biosynthetic process, positive regulation of heme biosynthetic process, positive regulation of iron-sulfur cluster assembly, transmembrane transport; MF: ABC-type iron-sulfur cluster transporter activity, ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Mitochondrial ABC transporters, Transport of small molecules
UniProt: Q61102
Entrez ID: 11306
|
Does Knockout of Chek1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Chek1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Chek1 (checkpoint kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, apoptotic process involved in development, cellular response to mechanical stimulus, chromatin remodeling, inner cell mass cell proliferation, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic nuclear membrane disassembly, negative regulation of DNA biosynthetic process, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell cycle phase transition, negative regulation of gene expression, epigenetic, negative regulation of mitotic nuclear division, nuclear envelope organization, nucleus organization, peptidyl-threonine phosphorylation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell cycle, regulation of cell population proliferation, regulation of double-strand break repair via homologous recombination, regulation of gene expression, regulation of mitotic centrosome separation, signal transduction in response to DNA damage; MF: ATP binding, histone H3T11 kinase activity, kinase activity, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, chromatin, chromosome, chromosome, telomeric region, condensed nuclear chromosome, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein-containing complex, replication fork
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Transcriptional Regulation by E2F6, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: O35280
Entrez ID: 12649
|
Does Knockout of Tbc1d24 in Microglial Cell Line causally result in response to virus?
| 1
| 2,429
|
Knockout
|
Tbc1d24
|
response to virus
|
Microglial Cell Line
|
Gene: Tbc1d24 (TBC1 domain family, member 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cellular response to oxidative stress, dendrite development, negative regulation of cellular response to oxidative stress, neuron projection development, positive regulation of dendrite morphogenesis, positive regulation of excitatory postsynaptic potential, positive regulation of neuron migration, synaptic vesicle endocytosis; CC: cell junction, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, neuromuscular junction, plasma membrane, presynapse, synapse, terminal bouton
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q3UUG6
Entrez ID: 224617
|
Does Knockout of Tefm in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Tefm
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tefm (transcription elongation factor, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of mitochondrial transcription, regulation of oxidative phosphorylation, transcription elongation by mitochondrial RNA polymerase; MF: nucleic acid binding, transcription elongation factor activity; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion, ribonucleoprotein complex
Pathways:
UniProt: Q5SSK3
Entrez ID: 68550
|
Does Knockout of Cnot2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Cnot2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cnot2 (CCR4-NOT transcription complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of transcription by RNA polymerase II, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of cytoplasmic mRNA processing body assembly, regulation of DNA-templated transcription, regulation of stem cell population maintenance, regulation of translation, regulatory ncRNA-mediated gene silencing, trophectodermal cell differentiation; MF: poly(A)-specific ribonuclease activity, transcription corepressor binding; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q8C5L3
Entrez ID: 72068
|
Does Knockout of Hspb9 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Hspb9
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hspb9 (heat shock protein, alpha-crystallin-related, B9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9DAM3
Entrez ID: 75482
|
Does Knockout of Kif23 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Kif23
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Kif23 (kinesin family member 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule-based movement, mitotic cytokinesis, mitotic spindle midzone assembly, positive regulation of cytokinesis; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding; CC: Flemming body, centralspindlin complex, centrosome, cytoplasm, cytoskeleton, intercellular bridge, kinesin complex, microtubule, midbody, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle, Mitotic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, M Phase, MHC class II antigen presentation, Membrane Trafficking, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Telophase/Cytokinesis, Vesicle-mediated transport
UniProt: E9Q5G3
Entrez ID: 71819
|
Does Knockout of Bcas1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Bcas1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Bcas1 (brain enriched myelin associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: myelination; CC: cytoplasm, cytosol, synapse
Pathways:
UniProt: Q80YN3
Entrez ID: 76960
|
Does Knockout of Ofd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Ofd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ofd1 (OFD1, centriole and centriolar satellite protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, cell projection organization, centriole replication, cilium assembly, embryonic body morphogenesis, epithelial cilium movement involved in determination of left/right asymmetry, mitotic cell cycle, mitotic spindle assembly, negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; MF: alpha-tubulin binding, gamma-tubulin binding, identical protein binding, molecular adaptor activity; CC: cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium, nucleus
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Hedgehog 'off' state, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Hedgehog
UniProt: Q80Z25
Entrez ID: 237222
|
Does Knockout of Ipo8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ipo8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ipo8 (importin 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, transmembrane transport; MF: ATPase-coupled transmembrane transporter activity, small GTPase binding; CC: cytoplasm, cytosol, nuclear envelope, nucleus, plasma membrane
Pathways: Gene Silencing by RNA, Gene expression (Transcription), Nucleocytoplasmic transport - Mus musculus (mouse), Transcriptional regulation by small RNAs
UniProt: Q7TMY7
Entrez ID: 320727
|
Does Knockout of Bcl2a1c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Bcl2a1c
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bcl2a1c (B cell leukemia/lymphoma 2 related protein A1c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, intrinsic apoptotic signaling pathway in response to DNA damage, mitochondrial fusion, negative regulation of apoptotic process, positive regulation of apoptotic process, regulation of apoptotic process, release of cytochrome c from mitochondria, transmembrane transport; MF: BH domain binding, channel activity, protein-containing complex binding; CC: cytoplasm, mitochondrial outer membrane
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q0P538
Entrez ID: 12046
|
Does Knockout of Timm17b in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Timm17b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Timm17b (translocase of inner mitochondrial membrane 17b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein import into mitochondrial matrix, protein transport; MF: protein transmembrane transporter activity; CC: TIM23 mitochondrial import inner membrane translocase complex, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9Z0V7
Entrez ID: 21855
|
Does Knockout of Cd300lb in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cd300lb
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cd300lb (CD300 molecule like family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, immune response-activating signaling pathway, immune system process, neutrophil mediated immunity, positive regulation of mast cell activation; MF: identical protein binding, protein binding, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Adaptive Immune System, DAP12 interactions, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System
UniProt: Q3U497
Entrez ID: 217304
|
Does Knockout of Sbds in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Sbds
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Sbds (SBDS ribosome maturation factor)
Type: protein-coding
Summary: This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: bone marrow development, bone mineralization, cytosolic ribosome assembly, hematopoietic progenitor cell differentiation, inner cell mass cell proliferation, leukocyte chemotaxis, mitotic spindle organization, rRNA processing, ribosome biogenesis; MF: microtubule binding, rRNA binding, ribosome binding; CC: cytoplasm, cytoskeleton, cytosol, nucleolus, nucleoplasm, nucleus, spindle, spindle pole
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: P70122
Entrez ID: 66711
|
Does Knockout of R3hdml in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
R3hdml
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: R3hdml (R3H domain containing-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, peptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: A2A5I3
Entrez ID: 100043899
|
Does Knockout of Adgra3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Adgra3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Adgra3 (adhesion G protein-coupled receptor A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q7TT36
Entrez ID: 70693
|
Does Knockout of Sh3bgrl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Sh3bgrl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sh3bgrl (SH3-binding domain glutamic acid-rich protein like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of cytoplasmic translational initiation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: SH3 domain binding, molecular_function, protein-RNA adaptor activity, ubiquitin-like ligase-substrate adaptor activity; CC: cytoplasm, cytosol, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q9JJU8
Entrez ID: 56726
|
Does Knockout of Ptprz1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ptprz1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ptprz1 (protein tyrosine phosphatase receptor type Z, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonal fasciculation, axonogenesis, hematopoietic progenitor cell differentiation, learning or memory, negative regulation of cell population proliferation, negative regulation of cell-substrate adhesion, negative regulation of dendrite development, negative regulation of neuron apoptotic process, neuron projection development, oligodendrocyte differentiation, peptidyl-tyrosine dephosphorylation, positive regulation of Schwann cell migration, positive regulation of cell migration, positive regulation of dendrite development, positive regulation of fibroblast proliferation, positive regulation of neuron migration, positive regulation of neuron projection development, positive regulation of oligodendrocyte differentiation, regulation of dendrite morphogenesis, regulation of myelination, regulation of oligodendrocyte progenitor proliferation, signal transduction; MF: fibroblast growth factor binding, hydrolase activity, integrin binding, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity; CC: axon, dendrite, dendritic spine, extracellular matrix, extracellular region, extracellular space, filopodium, glutamatergic synapse, growth cone, lamellipodium, membrane, neuronal cell body, perineuronal net, plasma membrane, postsynaptic density membrane, postsynaptic membrane, ruffle membrane, synapse
Pathways: Cytokine Signaling in Immune system, Immune System, MDK and PTN in ALK signaling, Other interleukin signaling, Signal Transduction, Signaling by ALK, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases
UniProt: B9EKR1
Entrez ID: 19283
|
Does Knockout of Ndufaf6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ndufaf6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ndufaf6 (NADH:ubiquinone oxidoreductase complex assembly factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: A2AIL4
Entrez ID: 76947
|
Does Knockout of Flii in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Flii
|
phagocytosis
|
macrophage
|
Gene: Flii (flightless I actin binding protein)
Type: protein-coding
Summary: This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: actin cytoskeleton organization, actin filament severing, actin polymerization or depolymerization, barbed-end actin filament capping, myofibril assembly, sarcomere organization; MF: actin binding, actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: actin cytoskeleton, anchoring junction, brush border, cell projection, centriolar satellite, centrosome, cytoplasm, cytoskeleton, cytosol, focal adhesion, nucleoplasm, nucleus, podosome
Pathways:
UniProt: Q9JJ28
Entrez ID: 14248
|
Does Knockout of Slc25a21 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Slc25a21
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc25a21 (solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, mitochondrial alpha-ketoglutarate transmembrane transport; MF: alpha-ketoglutarate transmembrane transporter activity, antiporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Lysine catabolism, Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8BZ09
Entrez ID: 217593
|
Does Knockout of Tada2b in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Tada2b
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Tada2b (transcriptional adaptor 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, regulation of transcription by RNA polymerase II; MF: chromatin binding, transcription coactivator activity; CC: SAGA-type complex, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: D3YW26, D3Z4Z0
Entrez ID: 231151
|
Does Knockout of Dchs1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Dchs1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dchs1 (dachsous cadherin related 1)
Type: protein-coding
Summary: Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and mitral valve morphogenesis. Acts upstream of or within several processes, including condensed mesenchymal cell proliferation; heart development; and post-anal tail morphogenesis. Located in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; heart; hemolymphoid system gland; and lung. Used to study mitral valve prolapse. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anatomical structure morphogenesis, branching involved in ureteric bud morphogenesis, cell adhesion, cell migration, cell migration involved in endocardial cushion formation, cell-cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cochlea development, condensed mesenchymal cell proliferation, digestive tract development, establishment of planar polarity, gene expression, heart morphogenesis, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, hippo signaling, homophilic cell adhesion via plasma membrane adhesion molecules, kidney development, mitral valve development, mitral valve formation, mitral valve morphogenesis, nephron development, neural tube development, neurogenesis, ossification involved in bone maturation, pattern specification process, post-anal tail morphogenesis, protein localization to plasma membrane, septin cytoskeleton organization; MF: beta-catenin binding, cadherin binding, calcium ion binding; CC: apical part of cell, catenin complex, membrane, plasma membrane, protein-containing complex
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: E9PVD3
Entrez ID: 233651
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