uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
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Q59.17 | Q59 | What is the genetic target of the small molecule drug Ozanimod, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Ozanimod is S1PR1. Ozanimod reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ozanimod%" OR LOWER(tradeNames_string) LIKE "%ozanimod%" OR LOWER(dr... | [{'UUID': 'DrugGeneTargets_v2_1976', 'drugName': 'Ozanimod', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'S1PR1 (ENSG00000170989)', 'yearOfFirstApproval': 2020, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_5399', 'drugName': 'Ozanimod Hydrochloride', 'drugMolec... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1550 | Q59 | What is the genetic target of the small molecule drug Linzagolix, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Linzagolix is GNRHR. Linzagolix reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%linzagolix%" OR LOWER(tradeNames_string) LIKE "%linzagolix%" OR LOWE... | [{'UUID': 'DrugGeneTargets_v2_628', 'drugName': 'Linzagolix', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'GNRHR (ENSG00000109163)', 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1081 | Q59 | What is the genetic target of the small molecule drug Betahistine, and what is its status in clinical trials and FDA approval? | There are 2 genetic targets of the small molecule drug Betahistine: HRH3 and HRH1. Betahistine reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%betahistine%" OR LOWER(tradeNames_string) LIKE "%betahistine%" OR LO... | [{'UUID': 'DrugGeneTargets_v2_6162', 'drugName': 'Betahistine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'HRH3 (ENSG00000101180), HRH1 (ENSG00000196639)', 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_6163', 'drugName': 'Betahistine'... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1972 | Q59 | What is the genetic target of the small molecule drug Mitapivat, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Mitapivat is PKLR. Mitapivat reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%mitapivat%" OR LOWER(tradeNames_string) LIKE "%mitapivat%" OR LOWER(... | [{'UUID': 'DrugGeneTargets_v2_4932', 'drugName': 'Mitapivat', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PKLR (ENSG00000143627)', 'yearOfFirstApproval': 2022, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_2811', 'drugName': 'Mitapivat Sulfate', 'drugMolecularT... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.552 | Q59 | What is the genetic target of the small molecule drug Avatrombopag Maleate, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Avatrombopag Maleate is MPL. Avatrombopag Maleate reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%avatrombopag maleate%" OR LOWER(tradeNames_string) LIKE "%avatrombop... | [{'UUID': 'DrugGeneTargets_v2_6317', 'drugName': 'Avatrombopag Maleate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'MPL (ENSG00000117400)', 'yearOfFirstApproval': 2018, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1554 | Q59 | What is the genetic target of the small molecule drug Lumateperone, and what is its status in clinical trials and FDA approval? | There are 3 genetic targets of the small molecule drug Lumateperone: DRD2, SLC6A4, and HTR2A. Lumateperone reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%lumateperone%" OR LOWER(tradeNames_string) LIKE "%lumateperone%" OR ... | [{'UUID': 'DrugGeneTargets_v2_3134', 'drugName': 'Lumateperone', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), SLC6A4 (ENSG00000108576), HTR2A (ENSG00000102468)', 'yearOfFirstApproval': 2019, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_3... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.665 | Q59 | What is the genetic target of the small molecule drug Naltrexone, and what is its status in clinical trials and FDA approval? | There are 3 genetic targets of the small molecule drug Naltrexone: OPRK1, OPRD1, and OPRM1. Naltrexone reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%naltrexone%" OR LOWER(tradeNames_string) LIKE "%naltrexone%" OR LOWE... | [{'UUID': 'DrugGeneTargets_v2_1780', 'drugName': 'Methylnaltrexone', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'yearOfFirstApproval': 2008, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_2413', 'drugName': 'Methylnaltrexone Bromide', ... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1626 | Q59 | What is the genetic target of the protein drug Cobitolimod, and what is its status in clinical trials and FDA approval? | The genetic target of the protein drug Cobitolimod is TLR9. Cobitolimod reached phase 3 clinical trials but is not approved by the FDA for treatment of any disease. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%cobitolimod%" OR LOWER(tradeNames_string) LIKE "%cobitolimod%" OR LO... | [{'UUID': 'DrugGeneTargets_v2_2420', 'drugName': 'Cobitolimod', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 3, 'drugIsApproved': False}] | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1028 | Q59 | What is the genetic target of the small molecule drug Dimethyl Fumarate, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Dimethyl Fumarate is KEAP1. Dimethyl Fumarate reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%dimethyl fumarate%" OR LOWER(tradeNames_string) LIKE "%dimethyl fuma... | [{'UUID': 'DrugGeneTargets_v2_3182', 'drugName': 'Dimethyl Fumarate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'KEAP1 (ENSG00000079999)', 'yearOfFirstApproval': 2013, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1994 | Q59 | What is the genetic target of the small molecule drug Jnj-18038683, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Jnj-18038683 is HTR7. Jnj-18038683 reached phase 2 clinical trials but is not approved by the FDA for treatment of any disease. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%jnj-18038683%" OR LOWER(tradeNames_string) LIKE "%jnj-18038683%" OR ... | [{'UUID': 'DrugGeneTargets_v2_696', 'drugName': 'Jnj-18038683', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'HTR7 (ENSG00000148680)', 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}, {'UUID': 'DrugGeneTargets_v2_3822', 'drugName': 'Jnj-18038683', 'drugMolecularType':... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1519 | Q59 | What is the genetic target of the small molecule drug Ritobegron, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Ritobegron is ADRB3. Ritobegron reached phase 3 clinical trials but is not approved by the FDA for treatment of any disease. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ritobegron%" OR LOWER(tradeNames_string) LIKE "%ritobegron%" OR LOWE... | [{'UUID': 'DrugGeneTargets_v2_3401', 'drugName': 'Ritobegron', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ADRB3 (ENSG00000188778)', 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 3, 'drugIsApproved': False}] | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.968 | Q59 | What is the genetic target of the small molecule drug Betrixaban, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Betrixaban is F10. Betrixaban reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%betrixaban%" OR LOWER(tradeNames_string) LIKE "%betrixaban%" OR LOWE... | [{'UUID': 'DrugGeneTargets_v2_5169', 'drugName': 'Betrixaban', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'F10 (ENSG00000126218)', 'yearOfFirstApproval': 2017, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.1883 | Q59 | What is the genetic target of the small molecule drug Hydrochlorothiazide, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Hydrochlorothiazide is SLC12A3. Hydrochlorothiazide reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%hydrochlorothiazide%" OR LOWER(tradeNames_string) LIKE "%hydrochloro... | [{'UUID': 'DrugGeneTargets_v2_4705', 'drugName': 'Chlorothiazide', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SLC12A3 (ENSG00000070915)', 'yearOfFirstApproval': 1958, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_1678', 'drugName': 'Hydrochlorothiazide', 'drug... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q59.287 | Q59 | What is the genetic target of the small molecule drug Tamoxifen, and what is its status in clinical trials and FDA approval? | The genetic target of the small molecule drug Tamoxifen is ESR1. Tamoxifen reached phase 4 clinical trials meaning it has been approved by the FDA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%tamoxifen%" OR LOWER(tradeNames_string) LIKE "%tamoxifen%" OR LOWER(... | [{'UUID': 'DrugGeneTargets_v2_4005', 'drugName': 'Tamoxifen', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ESR1 (ENSG00000091831)', 'yearOfFirstApproval': 1977, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_1083', 'drugName': 'Toremifene', 'drugMolecularType': '... | general | Distinct, Similarity Search, Order By | Approval Status, Trial Phase, Genetic Target |
Q6.589 | Q6 | What genes does Betrixaban target when it's used to treat Recurrent thrombophlebitis? | When used to treat Recurrent thrombophlebitis, the drug Betrixaban targets the gene F10. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%betrixaban%" OR LOWER(tradeNames_list) LIKE "%bet... | [{'UUID': 'DrugTargetsIndication121923_text_710818', 'drugName': 'Betrixaban', 'tradeNames_list': "['Bevyxxa']", 'syns_list': "['Betrixaban', 'Betrixaban maleate', 'PRT-054021', 'PRT054021']", 'target': 'ENSG00000126218', 'approvedSymbol': 'F10', 'approvedName': 'coagulation factor X', 'mesh_heading': 'Thrombosis', 'ef... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1868 | Q6 | What genes does Doxycycline target when it's used to treat periodontitis? | When used to treat periodontitis, the drug Doxycycline targets the genes MMP7, MMP1, MMP13, and MMP8. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%doxycycline%" OR LOWER(tradeNames_list) LIKE "%do... | [{'UUID': 'DrugTargetsIndication121923_text_1038217', 'drugName': 'Doxycycline', 'tradeNames_list': "['Doxychel', 'Doxycycline', 'Monodox', 'Oracea', 'Vibramycin']", 'syns_list': "['Doxirobe', 'Doxycycline', 'Doxycycline monohydrate', 'Doxylin', 'GS-3065Supracyclin', 'Xyrosa']", 'target': 'ENSG00000137673', 'approvedSy... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1061 | Q6 | What genes does Alendronic Acid target when it's used to treat prostate adenocarcinoma? | Alendronic Acid has not been approved by the FDA as a treatment for prostate adenocarcinoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is FDPS. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%alendronic acid%" OR LOWER(tradeNames_list) LIKE ... | [{'UUID': 'DrugTargetsIndication121923_text_1099518', 'drugName': 'Alendronic Acid', 'tradeNames_list': "['Binosto', 'Fosamax']", 'syns_list': "['Alendronate', 'Alendronic Acid', 'Alendronic acid', 'Fosamax']", 'target': 'ENSG00000160752', 'approvedSymbol': 'FDPS', 'approvedName': 'farnesyl diphosphate synthase', 'mesh... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1084 | Q6 | What genes does Avapritinib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Avapritinib targets the genes KIT and PDGFRA. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%avapritinib%" OR LOWER(tradeNames_list) LIKE "%av... | [{'UUID': 'DrugTargetsIndication121923_text_934033', 'drugName': 'Avapritinib', 'tradeNames_list': "['Ayvakit']", 'syns_list': "['70C366', 'Avapritinib', 'BLU-285', 'C-366', 'X-720776', 'X720776']", 'target': 'ENSG00000157404', 'approvedSymbol': 'KIT', 'approvedName': 'KIT proto-oncogene, receptor tyrosine kinase', 'me... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.925 | Q6 | What genes does Bromocriptine Mesylate target when it's used to treat Parkinson disease? | When used to treat Parkinson disease, the drug Bromocriptine Mesylate targets the genes DRD2, DRD3, and DRD4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bromocriptine mesylate%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_201379', 'drugName': 'Bromocriptine Mesylate', 'tradeNames_list': "['Bromocriptine mesylate', 'Cycloset', 'Parlodel']", 'syns_list': "['2-bromoergocryptine mesylate', 'Bromocriptine mesilateBromocriptine mesylate', 'Bromocriptine methanesulfonate', 'CB-154CB-154 MESYLATE', 'C... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.73 | Q6 | What genes does Fluticasone Propionate target when it's used to treat atopic eczema? | When used to treat atopic eczema, the drug Fluticasone Propionate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fluticasone propionate%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_232528', 'drugName': 'Fluticasone Propionate', 'tradeNames_list': "['Aerivio spiromax', 'Airflusal forspiro', 'Armonair digihalerArmonair respiclick', 'Cutivate', 'Flixonase', 'Flixotide', 'FlonaseFlonase allergy relief', 'Flovent', 'Flovent diskus 100Flovent diskus 250', 'Fl... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.435 | Q6 | What genes does Lonafarnib target when it's used to treat anaplastic astrocytoma? | Lonafarnib has not been approved by the FDA as a treatment for anaplastic astrocytoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are FNTA and FNTB. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lonafarnib%" OR LOWER(tradeNames_list) LIKE "%lon... | [{'UUID': 'DrugTargetsIndication121923_text_148987', 'drugName': 'Lonafarnib', 'tradeNames_list': "['Zokinvy']", 'syns_list': "['Lonafarnib', 'SCH 66336', 'SCH-66336', 'SCH66336', 'Sarasar']", 'target': 'ENSG00000257365', 'approvedSymbol': 'FNTB', 'approvedName': 'farnesyltransferase, CAAX box, beta', 'mesh_heading': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.911 | Q6 | What genes does Naproxen target when it's used to treat juvenile idiopathic arthritis? | When used to treat juvenile idiopathic arthritis, the drug Naproxen targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%naproxen%" OR LOWER(tradeNames_list) LIKE "%napro... | [{'UUID': 'DrugTargetsIndication121923_text_838130', 'drugName': 'Naproxen Sodium', 'tradeNames_list': "['Aleve', 'Anaprox', 'Anaprox ds', 'Naprelan', 'Naproxen sodium', 'Synflex']", 'syns_list': "['BAY-117031', 'BAY117031', 'BAYH6689', 'Naproxen sodiumNaproxen sodium anhydrous', 'Naproxen sodium salt', 'RS-3650']", 't... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.922 | Q6 | What genes does Phenylephrine Hydrochloride target when it's used to treat septic shock? | When used to treat septic shock, the drug Phenylephrine Hydrochloride targets the genes ADRA1A, ADRA1D, and ADRA1B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%phenylephrine hydrochloride%" OR LOWER(tradeNames... | [{'UUID': 'DrugTargetsIndication121923_text_416701', 'drugName': 'Phenylephrine Hydrochloride', 'tradeNames_list': "['Afrin 4 hour nasal spray', 'Biomydrin', 'Biorphen', 'Fenilfar', 'FenoxMydfrin', 'Nazex', 'Neo-synephrine', 'Neosynephrine', 'NostrilNurofen sinus pain relief', 'Phenylephrine hydrochloride', 'PrefrinVaz... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1679 | Q6 | What genes does Meloxicam target when it's used to treat rheumatoid arthritis? | When used to treat rheumatoid arthritis, the drug Meloxicam targets the gene PTGS2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%meloxicam%" OR LOWER(tradeNames_list) LIKE "%melo... | [{'UUID': 'DrugTargetsIndication121923_text_842373', 'drugName': 'Meloxicam', 'tradeNames_list': "['Anjeso', 'Meloxicam', 'Mobic', 'Qmiiz odt', 'Vivlodex']", 'syns_list': "['Acticam', 'Contacera', 'Coxicam', 'Emdocam', 'Flexicam', 'Inflacam', 'LoxicomMelfax', 'Melosus', 'Melovem', 'Meloxicam', 'Meloxidolor', 'Meloxidyl... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1272 | Q6 | What genes does Methotrexate target when it's used to treat leptomeningeal metastasis? | When used to treat leptomeningeal metastasis, the drug Methotrexate targets the gene DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%methotrexate%" OR LOWER(tradeNames_list) LIKE "%m... | [{'UUID': 'DrugTargetsIndication121923_text_1057595', 'drugName': 'Methotrexate', 'tradeNames_list': "['Amethopterin', 'Ebetrex', 'Emtexate high-pot', 'Emtexate pf', 'FolexMaxtrex', 'Methotrexate', 'Metoject', 'Mexate', 'Otrexup', 'Otrexup pfsRasuvo', 'Reditrex', 'Rheumatrex', 'Trexall', 'Zlatal']", 'syns_list': "['(r)... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1094 | Q6 | What genes does Cabozantinib target when it's used to treat clear cell renal carcinoma? | Cabozantinib has not been approved by the FDA as a treatment for clear cell renal carcinoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are KDR and MET. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cabozantinib%" OR LOWER(tradeNames_list) LIKE "%c... | [{'UUID': 'DrugTargetsIndication121923_text_669671', 'drugName': 'Cabozantinib S-Malate', 'tradeNames_list': "['Cabometyx', 'Cometriq']", 'syns_list': "['BMS-907351', 'Cabozantinib malate', 'Cabozantinib s-malate', 'XL-184XL184']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert dom... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.389 | Q6 | What genes does Naproxen target when it's used to treat tendinitis? | When used to treat tendinitis, the drug Naproxen targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%naproxen%" OR LOWER(tradeNames_list) LIKE "%napro... | [{'UUID': 'DrugTargetsIndication121923_text_838552', 'drugName': 'Naproxen', 'tradeNames_list': "['Aleve', 'Anaprox', 'Arthrosin 250', 'Arthrosin 250 ec', 'Arthrosin 500Arthrosin 500 ec', 'Condrotec', 'Ec-naprosyn', 'Equiproxen', 'Feminax ultraGrenoxal', 'Kenosyn', 'Laraflex', 'Napratec op', 'Naprosyn', 'Naprosyn 375Na... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.841 | Q6 | What genes does Pemetrexed target when it's used to treat mesothelioma? | When used to treat mesothelioma, the drug Pemetrexed targets the genes TYMS, GART, and DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pemetrexed%" OR LOWER(tradeNames_list) LIKE "%pem... | [{'UUID': 'DrugTargetsIndication121923_text_919045', 'drugName': 'Pemetrexed', 'tradeNames_list': "['Alimta', 'Pemfexy']", 'syns_list': "['LY-2315', 'LY-231514', 'LY231514', 'NSC-698037', 'Pemetrexed']", 'target': 'ENSG00000159131', 'approvedSymbol': 'GART', 'approvedName': 'phosphoribosylglycinamide formyltransferase,... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.774 | Q6 | What genes does Dexamethasone target when it's used to treat sympathetic ophthalmia? | When used to treat sympathetic ophthalmia, the drug Dexamethasone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dexamethasone%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_227795', 'drugName': 'Dexamethasone', 'tradeNames_list': "['Aeroseb-dex', 'Dalalone', 'Decaderm', 'Decadron', 'Decadron-75', 'DecasprayDexacortisyl', 'Dexafree', 'Dexamethasone', 'Dexamethasone intensolDexone', 'Dexone 0.5', 'Dexone 0.75', 'Dexone 1.5', 'Dexone 4', 'DexsolDex... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1805 | Q6 | What genes does Regorafenib target when it's used to treat colorectal cancer? | When used to treat colorectal cancer, the drug Regorafenib targets the genes KDR, FGFR1, FGFR2, ABL1, BRAF, TEK, FLT1, KIT, FLT4, PDGFRB, PDGFRA, RAF1, EPHA2, FRK, NTRK1, RET, DDR2, and MAPK11. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%regorafenib%" OR LOWER(tradeNames_list) LIKE "%re... | [{'UUID': 'DrugTargetsIndication121923_text_664247', 'drugName': 'Regorafenib', 'tradeNames_list': "['Stivarga']", 'syns_list': "['BAY 73-4506', 'BAY 73-4506 monohydrate', 'BAY-73-4506', 'BAY-734506Regorafenib', 'Regorafenib anhydrous', 'Regorafenib hydrateRegorafenib monohydrate']", 'target': 'ENSG00000077782', 'appro... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1992 | Q6 | What genes does Apremilast target when it's used to treat ankylosing spondylitis? | Apremilast has not been approved by the FDA as a treatment for ankylosing spondylitis, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PDE4A, PDE4D, PDE4B, and PDE4C. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%apremilast%" OR LOWER(tradeNames_list) LIKE "%apr... | [{'UUID': 'DrugTargetsIndication121923_text_696928', 'drugName': 'Apremilast', 'tradeNames_list': "['Otezla']", 'syns_list': "['Apremilast', 'CC-10004', 'CC10004']", 'target': 'ENSG00000065989', 'approvedSymbol': 'PDE4A', 'approvedName': 'phosphodiesterase 4A', 'mesh_heading': 'Spondylitis, Ankylosing', 'efo_term': 'an... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1066 | Q6 | What genes does Carbinoxamine Maleate target when it's used to treat angioedema? | When used to treat angioedema, the drug Carbinoxamine Maleate targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%carbinoxamine maleate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_455850', 'drugName': 'Carbinoxamine Maleate', 'tradeNames_list': "['Carbinoxamine maleate', 'Clistin', 'Davenol', 'Karbinal er']", 'syns_list': "['Carbinoxamine maleate', 'NSC-62362']", 'target': 'ENSG00000196639', 'approvedSymbol': 'HRH1', 'approvedName': 'histamine receptor... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.58 | Q6 | What genes does Leuprolide Acetate target when it's used to treat cancer? | Leuprolide Acetate has not been approved by the FDA as a treatment for cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is GNRHR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%leuprolide acetate%" OR LOWER(tradeNames_list) LI... | [{'UUID': 'DrugTargetsIndication121923_text_1097029', 'drugName': 'Leuprolide Acetate', 'tradeNames_list': "['Carcinil', 'Eligard', 'Eligard kit', 'Fensolvi kit', 'Leuprolide acetateLeuprorelin', 'Lupron', 'Lupron Depot Ped', 'Lupron depotLupron depot-ped', 'Lupron depot-ped kit', 'Lutrate depot kit', 'Viadur']", 'syns... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1688 | Q6 | What genes does Prednisolone Acetate target when it's used to treat eye inflammation? | When used to treat eye inflammation, the drug Prednisolone Acetate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%prednisolone acetate%" OR LOWER(tradeNames_list) ... | [{'UUID': 'DrugTargetsIndication121923_text_243761', 'drugName': 'Prednisolone Acetate', 'tradeNames_list': "['Econopred', 'Flo-pred', 'Meticortelone', 'Omnipred', 'Pred forte', 'Pred ftePred mild', 'Prednisolone acetate', 'Sterane', 'Ultracortenol']", 'syns_list': "['NSC-10966', 'Prednisolone 21-acetate', 'Prednisolon... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1955 | Q6 | What genes does Celecoxib target when it's used to treat colorectal neoplasm? | When used to treat colorectal neoplasm, the drug Celecoxib targets the gene PTGS2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%celecoxib%" OR LOWER(tradeNames_list) LIKE "%cele... | [{'UUID': 'DrugTargetsIndication121923_text_833167', 'drugName': 'Celecoxib', 'tradeNames_list': "['Celebra', 'Celebrex', 'Celecoxib', 'Elyxyb', 'Onsenal']", 'syns_list': "['Celecoxib', 'DFN-15', 'DFN15', 'NSC-719627', 'NSC-758624', 'SC-58635']", 'target': 'ENSG00000073756', 'approvedSymbol': 'PTGS2', 'approvedName': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1218 | Q6 | What genes does Ipratropium Bromide target when it's used to treat common cold? | When used to treat common cold, the drug Ipratropium Bromide targets the gene CHRM3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ipratropium bromide%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_857480', 'drugName': 'Ipratropium Bromide', 'tradeNames_list': "['Atrovent', 'Atrovent aerocaps', 'Atrovent fte', 'Atrovent hfaAtrovent udvs', 'Ipratrop', 'Ipratrop steripoule', 'Ipratropium bromideRespontin', 'Rinatec', 'Tropiovent']", 'syns_list': "['Ipratropium bromide', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1680 | Q6 | What genes does Doxycycline target when it's used to treat rosacea? | When used to treat rosacea, the drug Doxycycline targets the genes MMP7, MMP1, MMP13, and MMP8. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%doxycycline%" OR LOWER(tradeNames_list) LIKE "%do... | [{'UUID': 'DrugTargetsIndication121923_text_1038226', 'drugName': 'Doxycycline', 'tradeNames_list': "['Doxychel', 'Doxycycline', 'Monodox', 'Oracea', 'Vibramycin']", 'syns_list': "['Doxirobe', 'Doxycycline', 'Doxycycline monohydrate', 'Doxylin', 'GS-3065Supracyclin', 'Xyrosa']", 'target': 'ENSG00000137673', 'approvedSy... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1975 | Q6 | What genes does Cariprazine Hydrochloride target when it's used to treat schizophrenia? | When used to treat schizophrenia, the drug Cariprazine Hydrochloride targets the genes DRD2 and DRD3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cariprazine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_199891', 'drugName': 'Cariprazine Hydrochloride', 'tradeNames_list': "['Vraylar']", 'syns_list': "['Cariprazine hcl', 'Cariprazine hydrochloride', 'RGH-188 HCL']", 'target': 'ENSG00000149295', 'approvedSymbol': 'DRD2', 'approvedName': 'dopamine receptor D2', 'mesh_heading': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.213 | Q6 | What genes does Alcaftadine target when it's used to treat allergic conjunctivitis? | When used to treat allergic conjunctivitis, the drug Alcaftadine targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%alcaftadine%" OR LOWER(tradeNames_list) LIKE "%al... | [{'UUID': 'DrugTargetsIndication121923_text_455861', 'drugName': 'Alcaftadine', 'tradeNames_list': "['Lastacaft']", 'syns_list': "['Alcaftadine', 'R 89674', 'R-89674']", 'target': 'ENSG00000196639', 'approvedSymbol': 'HRH1', 'approvedName': 'histamine receptor H1', 'mesh_heading': 'Conjunctivitis, Allergic', 'efo_term'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1534 | Q6 | What genes does Nitric Oxide target when it's used to treat Respiratory insufficiency? | When used to treat Respiratory insufficiency, the drug Nitric Oxide targets the genes GUCY1B1, GUCY1B2, GUCY1A2, and GUCY1A1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%nitric oxide%" OR LOWER(tradeNames_list) LIKE "%n... | [{'UUID': 'DrugTargetsIndication121923_text_974262', 'drugName': 'Nitric Oxide', 'tradeNames_list': "['Genosyl', 'Inomax']", 'syns_list': "['Amidogen, oxo-', 'Inovent', 'Nitric oxide', 'Nitric oxide trimerNitrogen oxide (no)', 'Nitrosyl radical', 'OHM-11771']", 'target': 'ENSG00000061918', 'approvedSymbol': 'GUCY1B1', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1135 | Q6 | What genes does Abemaciclib target when it's used to treat breast carcinoma? | When used to treat breast carcinoma, the drug Abemaciclib targets the genes CDK4 and CDK6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%abemaciclib%" OR LOWER(tradeNames_list) LIKE "%ab... | [{'UUID': 'DrugTargetsIndication121923_text_849246', 'drugName': 'Abemaciclib', 'tradeNames_list': "['Verzenio', 'Verzenios']", 'syns_list': "['Abemaciclib', 'LY-2835219', 'LY2835219', 'Ly-2835219']", 'target': 'ENSG00000135446', 'approvedSymbol': 'CDK4', 'approvedName': 'cyclin dependent kinase 4', 'mesh_heading': 'Br... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.131 | Q6 | What genes does Erdafitinib target when it's used to treat metastatic prostate cancer? | Erdafitinib has not been approved by the FDA as a treatment for metastatic prostate cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are FGFR1, FGFR3, FGFR2, and FGFR4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%erdafitinib%" OR LOWER(tradeNames_list) LIKE "%er... | [{'UUID': 'DrugTargetsIndication121923_text_707166', 'drugName': 'Erdafitinib', 'tradeNames_list': "['Balversa']", 'syns_list': "['Erdafitinib', 'JNJ-42756493', 'Jnj-42756493']", 'target': 'ENSG00000077782', 'approvedSymbol': 'FGFR1', 'approvedName': 'fibroblast growth factor receptor 1', 'mesh_heading': 'Prostatic Neo... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.819 | Q6 | What genes does Dimethyl Fumarate target when it's used to treat multiple sclerosis? | When used to treat multiple sclerosis, the drug Dimethyl Fumarate targets the gene KEAP1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dimethyl fumarate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1055847', 'drugName': 'Dimethyl Fumarate', 'tradeNames_list': "['Tecfidera']", 'syns_list': "['AZL 0 211089', 'AZL O 211089', 'AZL-0211089', 'AZL-O-211089', 'BG 00012BG 12', 'BG-00012', 'BG-12', 'BG00012', 'Dimethyl fumar', 'Dimethyl fumarateFAG-201', 'FP-187', 'FP187', 'Fuma... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1282 | Q6 | What genes does Nepafenac target when it's used to treat inflammation? | When used to treat inflammation, the drug Nepafenac targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%nepafenac%" OR LOWER(tradeNames_list) LIKE "%nepa... | [{'UUID': 'DrugTargetsIndication121923_text_828596', 'drugName': 'Nepafenac', 'tradeNames_list': "['Ilevro', 'Nepafenac', 'Nevanac']", 'syns_list': "['AHR-9434', 'AL-6515', 'Nepafenac']", 'target': 'ENSG00000073756', 'approvedSymbol': 'PTGS2', 'approvedName': 'prostaglandin-endoperoxide synthase 2', 'mesh_heading': 'Ey... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1872 | Q6 | What genes does Amlodipine Besylate target when it's used to treat myocardial infarction? | When used to treat myocardial infarction, the drug Amlodipine Besylate targets the genes CACNA1C, CACNA1S, CACNA1D, and CACNA1F. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%amlodipine besylate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_1043735', 'drugName': 'Amlodipine Besylate', 'tradeNames_list': "['Amlodipine besylate', 'Norliqva', 'Norvasc']", 'syns_list': "['Amlodipine (as besilate)', 'Amlodipine benzenesulfonateAmlodipine besilate', 'Amlodipine besylate', 'Amlor', 'AntacalLodipressin', 'Monopina', 'NS... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.438 | Q6 | What genes does Diroximel Fumarate target when it's used to treat multiple sclerosis? | When used to treat multiple sclerosis, the drug Diroximel Fumarate targets the gene KEAP1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%diroximel fumarate%" OR LOWER(tradeNames_list) LI... | [{'UUID': 'DrugTargetsIndication121923_text_1055623', 'drugName': 'Diroximel Fumarate', 'tradeNames_list': "['Vumerity']", 'syns_list': "['ALKS 8700', 'ALKS-8700', 'ALKS8700', 'Alks 8700', 'BIIB-098', 'BIIB098Diroximel fumarate', 'RDC-5108', 'RDC5108']", 'target': 'ENSG00000079999', 'approvedSymbol': 'KEAP1', 'approved... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.417 | Q6 | What genes does Pegcetacoplan target when it's used to treat immune system disease? | When used to treat immune system disease, the drug Pegcetacoplan targets the gene C3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pegcetacoplan%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_1103147', 'drugName': 'Pegcetacoplan', 'tradeNames_list': "['Empaveli']", 'syns_list': "['APL-2', 'Pegcetacoplan']", 'target': 'ENSG00000125730', 'approvedSymbol': 'C3', 'approvedName': 'complement C3', 'mesh_heading': 'Immune System Diseases', 'efo_term': 'immune system dise... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1504 | Q6 | What genes does Gemcitabine Hydrochloride target when it's used to treat leukemia? | Gemcitabine Hydrochloride has not been approved by the FDA as a treatment for leukemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are POLA1, POLD4, POLD3, POLD1, POLD2, POLE, POLA2, PRIM1, PRIM2, POLE2, POLE3, RRM1, RRM2B, and RRM2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%gemcitabine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_755877', 'drugName': 'Gemcitabine Hydrochloride', 'tradeNames_list': "['Gemcitabine hydrochloride', 'Gemzar', 'Infugem']", 'syns_list': "['Gemcitabine (as hydrochloride)', 'Gemcitabine hclGemcitabine hydrochloride', 'Gemzar', 'LY-188011LY-188011 HYDROCHLORIDE', 'LY188011 HYDR... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.234 | Q6 | What genes does Olaparib target when it's used to treat ovarian neoplasm? | When used to treat ovarian neoplasm, the drug Olaparib targets the genes PARP2, PARP1, and PARP3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%olaparib%" OR LOWER(tradeNames_list) LIKE "%olapa... | [{'UUID': 'DrugTargetsIndication121923_text_795125', 'drugName': 'Olaparib', 'tradeNames_list': "['Lynparza']", 'syns_list': "['AZ-2281', 'AZ2281', 'AZD-2281', 'AZD2281', 'KEYLYNK-010 COMPONENT OLAPARIBKU-0059436', 'KU-59436', 'NSC-747856', 'OLAPARIB COMPONENT OF KEYLYNK-010Olaparib']", 'target': 'ENSG00000129484', 'ap... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1708 | Q6 | What genes does Bortezomib target when it's used to treat ovarian cancer? | Bortezomib has not been approved by the FDA as a treatment for ovarian cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSM... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bortezomib%" OR LOWER(tradeNames_list) LIKE "%bor... | [{'UUID': 'DrugTargetsIndication121923_text_342319', 'drugName': 'Bortezomib', 'tradeNames_list': "['Velcade']", 'syns_list': "['Bortezomib', 'Bortezomib accord', 'Bortezomib hydrate', 'LDP-341NSC-681239', 'PS-341', 'Velcade']", 'target': 'ENSG00000126067', 'approvedSymbol': 'PSMB2', 'approvedName': 'proteasome 20S sub... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.895 | Q6 | What genes does Leuprolide Acetate target when it's used to treat Central precocious puberty? | When used to treat Central precocious puberty, the drug Leuprolide Acetate targets the gene GNRHR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%leuprolide acetate%" OR LOWER(tradeNames_list) LI... | [{'UUID': 'DrugTargetsIndication121923_text_1097052', 'drugName': 'Leuprolide Acetate', 'tradeNames_list': "['Carcinil', 'Eligard', 'Eligard kit', 'Fensolvi kit', 'Leuprolide acetateLeuprorelin', 'Lupron', 'Lupron Depot Ped', 'Lupron depotLupron depot-ped', 'Lupron depot-ped kit', 'Lutrate depot kit', 'Viadur']", 'syns... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1625 | Q6 | What genes does Megestrol Acetate target when it's used to treat intraepithelial neoplasia? | Megestrol Acetate has not been approved by the FDA as a treatment for intraepithelial neoplasia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is PGR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%megestrol acetate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_940565', 'drugName': 'Megestrol Acetate', 'tradeNames_list': "['Megace', 'Megace es', 'Megestrol acetate', 'Ovaban']", 'syns_list': "['5071', 'BDH 1298', 'BDH-1298', 'Chronopil', 'Megesterol acetate', 'MegestrolMegestrol 17.alpha.-acetate', 'Megestrol acetate', 'NSC-71423', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.699 | Q6 | What genes does Lamotrigine target when it's used to treat Lennox-Gastaut syndrome? | When used to treat Lennox-Gastaut syndrome, the drug Lamotrigine targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lamotrigine%" OR LOWER(tradeNames_list) LIKE "%la... | [{'UUID': 'DrugTargetsIndication121923_text_653157', 'drugName': 'Lamotrigine', 'tradeNames_list': "['Lamictal', 'Lamictal cd', 'Lamictal odt', 'Lamictal xr', 'Lamotrigine']", 'syns_list': "['BW 430C', 'BW-430C', 'Lamotrigine', 'NSC-759171']", 'target': 'ENSG00000144285', 'approvedSymbol': 'SCN1A', 'approvedName': 'sod... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1769 | Q6 | What genes does Linagliptin target when it's used to treat type 2 diabetes mellitus? | When used to treat type 2 diabetes mellitus, the drug Linagliptin targets the gene DPP4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%linagliptin%" OR LOWER(tradeNames_list) LIKE "%li... | [{'UUID': 'DrugTargetsIndication121923_text_932957', 'drugName': 'Linagliptin', 'tradeNames_list': "['Tradjenta', 'Trajenta']", 'syns_list': "['BI 1356', 'BI 1356 BS', 'BI-1356', 'BI-1356-BS', 'BI-1356BS', 'BS 1356 BSBS-1356-BS', 'Linagliptin', 'Trazenta']", 'target': 'ENSG00000197635', 'approvedSymbol': 'DPP4', 'appro... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.301 | Q6 | What genes does Rufinamide target when it's used to treat epilepsy? | When used to treat epilepsy, the drug Rufinamide targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%rufinamide%" OR LOWER(tradeNames_list) LIKE "%ruf... | [{'UUID': 'DrugTargetsIndication121923_text_652674', 'drugName': 'Rufinamide', 'tradeNames_list': "['Banzel', 'Inovelon', 'Rufinamide']", 'syns_list': "['60231/4', 'CGP 33101', 'CGP-33101', 'E-2080', 'E2080', 'RUF 331', 'RUF-331Rufinamide']", 'target': 'ENSG00000144285', 'approvedSymbol': 'SCN1A', 'approvedName': 'sodi... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1399 | Q6 | What genes does Megestrol Acetate target when it's used to treat cancer? | When used to treat cancer, the drug Megestrol Acetate targets the gene PGR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%megestrol acetate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_940555', 'drugName': 'Megestrol Acetate', 'tradeNames_list': "['Megace', 'Megace es', 'Megestrol acetate', 'Ovaban']", 'syns_list': "['5071', 'BDH 1298', 'BDH-1298', 'Chronopil', 'Megesterol acetate', 'MegestrolMegestrol 17.alpha.-acetate', 'Megestrol acetate', 'NSC-71423', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1987 | Q6 | What genes does Amlodipine Benzoate target when it's used to treat hypertension? | When used to treat hypertension, the drug Amlodipine Benzoate targets the genes CACNA1C, CACNA1S, CACNA1D, and CACNA1F. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%amlodipine benzoate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_1044026', 'drugName': 'Amlodipine Benzoate', 'tradeNames_list': "['Katerzia']", 'syns_list': "['Amlodipine benzoate']", 'target': 'ENSG00000151067', 'approvedSymbol': 'CACNA1C', 'approvedName': 'calcium voltage-gated channel subunit alpha1 C', 'mesh_heading': 'Hypertension', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.102 | Q6 | What genes does Carfilzomib target when it's used to treat cancer? | When used to treat cancer, the drug Carfilzomib targets the genes PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSMB3, PSMB4, PSMB7, ADRM1, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD3, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSM... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%carfilzomib%" OR LOWER(tradeNames_list) LIKE "%ca... | [{'UUID': 'DrugTargetsIndication121923_text_269980', 'drugName': 'Carfilzomib', 'tradeNames_list': "['Kyprolis']", 'syns_list': "['Carfilzomib', 'NSC-758252', 'PR-171']", 'target': 'ENSG00000126067', 'approvedSymbol': 'PSMB2', 'approvedName': 'proteasome 20S subunit beta 2', 'mesh_heading': 'Neoplasms', 'efo_term': 'ca... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.831 | Q6 | What genes does Everolimus target when it's used to treat anaplastic astrocytoma? | When used to treat anaplastic astrocytoma, the drug Everolimus targets the gene FKBP1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%everolimus%" OR LOWER(tradeNames_list) LIKE "%eve... | [{'UUID': 'DrugTargetsIndication121923_text_1085635', 'drugName': 'Everolimus', 'tradeNames_list': "['Afinitor', 'Afinitor disperz', 'Certican', 'Votubia', 'Zortress']", 'syns_list': "['40-o-(2-hydroxyethyl)-rapamycin', 'Everolimus', 'RAD 666', 'RAD-001RAD-666', 'RAD001', 'SDZ-RAD', 'Sdz rad']", 'target': 'ENSG00000088... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.359 | Q6 | What genes does Olaparib target when it's used to treat ovarian carcinoma? | When used to treat ovarian carcinoma, the drug Olaparib targets the genes PARP2, PARP1, and PARP3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%olaparib%" OR LOWER(tradeNames_list) LIKE "%olapa... | [{'UUID': 'DrugTargetsIndication121923_text_795391', 'drugName': 'Olaparib', 'tradeNames_list': "['Lynparza']", 'syns_list': "['AZ-2281', 'AZ2281', 'AZD-2281', 'AZD2281', 'KEYLYNK-010 COMPONENT OLAPARIBKU-0059436', 'KU-59436', 'NSC-747856', 'OLAPARIB COMPONENT OF KEYLYNK-010Olaparib']", 'target': 'ENSG00000129484', 'ap... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.114 | Q6 | What genes does Vorinostat target when it's used to treat breast cancer? | Vorinostat has not been approved by the FDA as a treatment for breast cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are HDAC1, HDAC3, HDAC6, and HDAC2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%vorinostat%" OR LOWER(tradeNames_list) LIKE "%vor... | [{'UUID': 'DrugTargetsIndication121923_text_1077123', 'drugName': 'Vorinostat', 'tradeNames_list': "['Zolinza']", 'syns_list': "['MK-0683', 'MK0683', 'NSC-701852', 'NSC-748799', 'NSC-759852Suberoylanilide hydroxamic acid', 'Vorinostat']", 'target': 'ENSG00000116478', 'approvedSymbol': 'HDAC1', 'approvedName': 'histone ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1440 | Q6 | What genes does Risdiplam target when it's used to treat Atrophy? | When used to treat Atrophy, the drug Risdiplam targets the gene SMN2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%risdiplam%" OR LOWER(tradeNames_list) LIKE "%risd... | [{'UUID': 'DrugTargetsIndication121923_text_1072736', 'drugName': 'Risdiplam', 'tradeNames_list': "['Evrysdi']", 'syns_list': "['RG-7916', 'RG7916', 'RO-7034067', 'RO7034067', 'Risdiplam']", 'target': 'ENSG00000205571', 'approvedSymbol': 'SMN2', 'approvedName': 'survival of motor neuron 2, centromeric', 'mesh_heading':... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1840 | Q6 | What genes does Bupivacaine target when it's used to treat peritoneum cancer? | Bupivacaine has not been approved by the FDA as a treatment for peritoneum cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is SCN4A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bupivacaine%" OR LOWER(tradeNames_list) LIKE "%bu... | [{'UUID': 'DrugTargetsIndication121923_text_663123', 'drugName': 'Bupivacaine', 'tradeNames_list': "['Anekain', 'Exparel', 'Marcaine', 'Posimir', 'Sensorcaine']", 'syns_list': "['Bucaine', 'Bupivacaine', 'Bupivacaine liposome', 'LIQ-865', 'LIQ865Liposomal bupivacaine', 'MarcaineRopivacaine hydrochloride impurity, bupiv... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.952 | Q6 | What genes does Topotecan Hydrochloride target when it's used to treat small cell carcinoma? | When used to treat small cell carcinoma, the drug Topotecan Hydrochloride targets the gene TOP1MT. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%topotecan hydrochloride%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_1193576', 'drugName': 'Topotecan Hydrochloride', 'tradeNames_list': "['Hycamptin', 'Hycamtin', 'Topotecan', 'Topotecan hydrochloride']", 'syns_list': "['Evotopin', 'NSC-759263', 'Nogitecan hydrochloride', 'SK&F S-104864-ASK&F-S-104864A', 'SK-S-104864-A', 'Topotecan (as hydroc... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1186 | Q6 | What genes does Leuprolide Acetate target when it's used to treat Alzheimer disease? | Leuprolide Acetate has not been approved by the FDA as a treatment for Alzheimer disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is GNRHR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%leuprolide acetate%" OR LOWER(tradeNames_list) LI... | [{'UUID': 'DrugTargetsIndication121923_text_1097104', 'drugName': 'Leuprolide Acetate', 'tradeNames_list': "['Carcinil', 'Eligard', 'Eligard kit', 'Fensolvi kit', 'Leuprolide acetateLeuprorelin', 'Lupron', 'Lupron Depot Ped', 'Lupron depotLupron depot-ped', 'Lupron depot-ped kit', 'Lutrate depot kit', 'Viadur']", 'syns... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.456 | Q6 | What genes does Aspirin target when it's used to treat retinal artery occlusion? | Aspirin has not been approved by the FDA as a treatment for retinal artery occlusion, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%aspirin%" OR LOWER(tradeNames_list) LIKE "%aspiri... | [{'UUID': 'DrugTargetsIndication121923_text_834399', 'drugName': 'Aspirin', 'tradeNames_list': "['8-hour bayer', 'Acetosalic Acid', 'Acetylsalic acidAcetylsalicylic Acid', 'Alka rapid', 'Anadin all night', 'Angettes 75Aspirin', 'Aspro clr', 'Bayer extra strength aspirin for migraine painDanamep', 'Disprin cv', 'Disprin... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.876 | Q6 | What genes does Docetaxel target when it's used to treat breast carcinoma? | When used to treat breast carcinoma, the drug Docetaxel targets the genes TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%docetaxel%" OR LOWER(tradeNames_list) LIKE "%doce... | [{'UUID': 'DrugTargetsIndication121923_text_100381', 'drugName': 'Docetaxel', 'tradeNames_list': "['Docefrez', 'Docetaxel', 'Taxceus', 'Taxotere']", 'syns_list': "['Bind 014', 'CKD-810', 'Docetaxel', 'Docetaxel (as trihydrate)Docetaxel anhydrous', 'Docetaxel hydrate', 'Docetaxel trihydrateNSC-628503', 'RP 56976', 'RP-5... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1545 | Q6 | What genes does Desvenlafaxine target when it's used to treat depressive disorder? | When used to treat depressive disorder, the drug Desvenlafaxine targets the genes SLC6A4 and SLC6A2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%desvenlafaxine%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_206622', 'drugName': 'Desvenlafaxine', 'tradeNames_list': "['Desvenlafaxine', 'Khedezla', 'Pristiq']", 'syns_list': "['D-veniz', 'Desvenlafaxine', 'Mdd-xr', 'Newven', 'O-desmethylvenlafaxineODV']", 'target': 'ENSG00000108576', 'approvedSymbol': 'SLC6A4', 'approvedName': 'solu... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1701 | Q6 | What genes does Fosaprepitant Dimeglumine target when it's used to treat Chemotherapy-induced nausea and vomiting? | When used to treat Chemotherapy-induced nausea and vomiting, the drug Fosaprepitant Dimeglumine targets the gene TACR1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fosaprepitant dimeglumine%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_1073181', 'drugName': 'Fosaprepitant Dimeglumine', 'tradeNames_list': "['Emend', 'Fosaprepitant dimeglumine']", 'syns_list': "['Fosaprepitant (as dimeglumine)', 'Fosaprepitant dimeglumineFosaprepitant meglumine', 'MK-0517']", 'target': 'ENSG00000115353', 'approvedSymbol': 'TA... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1436 | Q6 | What genes does Olopatadine Hydrochloride target when it's used to treat allergic conjunctivitis? | When used to treat allergic conjunctivitis, the drug Olopatadine Hydrochloride targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%olopatadine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_455975', 'drugName': 'Olopatadine Hydrochloride', 'tradeNames_list': "['Olopatadine hydrochloride', 'Pataday', 'Pataday once daily reliefPataday twice daily relief', 'Patanase', 'Patanol', 'Pazeo']", 'syns_list': "['ALO-4943A', 'ALO4943A', 'Allelock', 'KW-4679', 'KW4679Olopat... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.915 | Q6 | What genes does Gemcitabine Hydrochloride target when it's used to treat breast carcinoma? | When used to treat breast carcinoma, the drug Gemcitabine Hydrochloride targets the genes POLA1, POLD4, POLD3, POLD1, POLD2, POLE, POLA2, PRIM1, PRIM2, POLE2, POLE3, RRM1, RRM2B, and RRM2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%gemcitabine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_760118', 'drugName': 'Gemcitabine Hydrochloride', 'tradeNames_list': "['Gemcitabine hydrochloride', 'Gemzar', 'Infugem']", 'syns_list': "['Gemcitabine (as hydrochloride)', 'Gemcitabine hclGemcitabine hydrochloride', 'Gemzar', 'LY-188011LY-188011 HYDROCHLORIDE', 'LY188011 HYDR... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.310 | Q6 | What genes does Acetaminophen target when it's used to treat pain? | When used to treat pain, the drug Acetaminophen targets the genes PTGS2, PTGS1, TRPV1, and FAAH. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%acetaminophen%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_830308', 'drugName': 'Acetaminophen', 'tradeNames_list': '[\'Abdine\', \'Acephen\', \'Acetaminophen\', \'Alvedon\', \'Angiers\', \'CalpolCalpol six plus\', \'Calpol six plus fastmelts\', \'Child lemsip\', \'CupanolDafalgan\', \'Datril\', \'Disprol\', \'Disprol infant\', \'Dis... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1257 | Q6 | What genes does Everolimus target when it's used to treat Autosomal dominant polycystic kidney disease? | Everolimus has not been approved by the FDA as a treatment for Autosomal dominant polycystic kidney disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is FKBP1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%everolimus%" OR LOWER(tradeNames_list) LIKE "%eve... | [{'UUID': 'DrugTargetsIndication121923_text_1085618', 'drugName': 'Everolimus', 'tradeNames_list': "['Afinitor', 'Afinitor disperz', 'Certican', 'Votubia', 'Zortress']", 'syns_list': "['40-o-(2-hydroxyethyl)-rapamycin', 'Everolimus', 'RAD 666', 'RAD-001RAD-666', 'RAD001', 'SDZ-RAD', 'Sdz rad']", 'target': 'ENSG00000088... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1409 | Q6 | What genes does Lenalidomide target when it's used to treat T-cell non-Hodgkin lymphoma? | Lenalidomide has not been approved by the FDA as a treatment for T-cell non-Hodgkin lymphoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CRBN, DDB1, CUL4A, and RBX1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lenalidomide%" OR LOWER(tradeNames_list) LIKE "%l... | [{'UUID': 'DrugTargetsIndication121923_text_1106148', 'drugName': 'Lenalidomide', 'tradeNames_list': "['Revlimid']", 'syns_list': "['CC-5013', 'CDC-501', 'Lenalidomide', 'NSC-747972', 'SYP-1512']", 'target': 'ENSG00000113851', 'approvedSymbol': 'CRBN', 'approvedName': 'cereblon', 'mesh_heading': 'Lymphoma, T-Cell', 'ef... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.618 | Q6 | What genes does Carbinoxamine Maleate target when it's used to treat urticaria? | When used to treat urticaria, the drug Carbinoxamine Maleate targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%carbinoxamine maleate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_455849', 'drugName': 'Carbinoxamine Maleate', 'tradeNames_list': "['Carbinoxamine maleate', 'Clistin', 'Davenol', 'Karbinal er']", 'syns_list': "['Carbinoxamine maleate', 'NSC-62362']", 'target': 'ENSG00000196639', 'approvedSymbol': 'HRH1', 'approvedName': 'histamine receptor... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1479 | Q6 | What genes does Abemaciclib target when it's used to treat breast neoplasm? | When used to treat breast neoplasm, the drug Abemaciclib targets the genes CDK4 and CDK6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%abemaciclib%" OR LOWER(tradeNames_list) LIKE "%ab... | [{'UUID': 'DrugTargetsIndication121923_text_850521', 'drugName': 'Abemaciclib', 'tradeNames_list': "['Verzenio', 'Verzenios']", 'syns_list': "['Abemaciclib', 'LY-2835219', 'LY2835219', 'Ly-2835219']", 'target': 'ENSG00000105810', 'approvedSymbol': 'CDK6', 'approvedName': 'cyclin dependent kinase 6', 'mesh_heading': 'Br... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.250 | Q6 | What genes does Desonide target when it's used to treat eye inflammation? | When used to treat eye inflammation, the drug Desonide targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%desonide%" OR LOWER(tradeNames_list) LIKE "%deson... | [{'UUID': 'DrugTargetsIndication121923_text_217430', 'drugName': 'Desonide', 'tradeNames_list': "['Desonate', 'Desonide', 'Desowen', 'Tridesilon', 'Verdeso']", 'syns_list': "['D-2083', 'D2083', 'Desonate', 'Desonide', 'NSC-759226']", 'target': 'ENSG00000113580', 'approvedSymbol': 'NR3C1', 'approvedName': 'nuclear recep... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.734 | Q6 | What genes does Lidocaine target when it's used to treat Back pain? | When used to treat Back pain, the drug Lidocaine targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lidocaine%" OR LOWER(tradeNames_list) LIKE "%lido... | [{'UUID': 'DrugTargetsIndication121923_text_640883', 'drugName': 'Lidocaine', 'tradeNames_list': "['Alphacaine', 'Anestacon', 'Dentipatch', 'Lidocaine', 'LidodermLignocaine Hcl', 'Lignostab', 'Lmx 4', 'Oraqix', 'Vagisil', 'XylocaineXylodase', 'Xylotox', 'Ztlido']", 'syns_list': "['ALGRX 3268', 'ALGRX-3268', 'Anestacon'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.311 | Q6 | What genes does Fluorouracil target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Fluorouracil targets the gene TYMS. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fluorouracil%" OR LOWER(tradeNames_list) LIKE "%f... | [{'UUID': 'DrugTargetsIndication121923_text_919463', 'drugName': 'Fluorouracil', 'tradeNames_list': "['5.f.u.', 'Accusite', 'Actikerall', 'Adrucil', 'Carac', 'Efudex', 'EfudixFluoro-uracil roche', 'Fluoroplex', 'Fluorouracil', 'Tolak']", 'syns_list': "['5 FU', '5-FU', '5-Fluorouracil', '5-fluoruracil', 'FluorouracilFlu... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.236 | Q6 | What genes does Larotrectinib Sulfate target when it's used to treat cancer? | When used to treat cancer, the drug Larotrectinib Sulfate targets the genes NTRK1, NTRK2, and NTRK3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%larotrectinib sulfate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_942616', 'drugName': 'Larotrectinib Sulfate', 'tradeNames_list': "['Vitrakvi']", 'syns_list': "['ARRY-470 SULFATE', 'LOXO-101 sulfate', 'Larotrectinib sulfate']", 'target': 'ENSG00000198400', 'approvedSymbol': 'NTRK1', 'approvedName': 'neurotrophic receptor tyrosine kinase 1'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.72 | Q6 | What genes does Nitric Oxide target when it's used to treat respiratory failure? | When used to treat respiratory failure, the drug Nitric Oxide targets the genes GUCY1B1, GUCY1B2, GUCY1A2, and GUCY1A1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%nitric oxide%" OR LOWER(tradeNames_list) LIKE "%n... | [{'UUID': 'DrugTargetsIndication121923_text_974424', 'drugName': 'Nitric Oxide', 'tradeNames_list': "['Genosyl', 'Inomax']", 'syns_list': "['Amidogen, oxo-', 'Inovent', 'Nitric oxide', 'Nitric oxide trimerNitrogen oxide (no)', 'Nitrosyl radical', 'OHM-11771']", 'target': 'ENSG00000061918', 'approvedSymbol': 'GUCY1B1', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.896 | Q6 | What genes does Rivaroxaban target when it's used to treat Venous thrombosis? | When used to treat Venous thrombosis, the drug Rivaroxaban targets the gene F10. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%rivaroxaban%" OR LOWER(tradeNames_list) LIKE "%ri... | [{'UUID': 'DrugTargetsIndication121923_text_708753', 'drugName': 'Rivaroxaban', 'tradeNames_list': "['Xarelto']", 'syns_list': "['BAY 59-7939', 'BAY-59-7939', 'JNJ-39039039', 'JNJ39039039', 'Rivaroxaban']", 'target': 'ENSG00000126218', 'approvedSymbol': 'F10', 'approvedName': 'coagulation factor X', 'mesh_heading': 'Ve... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1754 | Q6 | What genes does Zanubrutinib target when it's used to treat lupus nephritis? | Zanubrutinib has not been approved by the FDA as a treatment for lupus nephritis, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is BTK. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%zanubrutinib%" OR LOWER(tradeNames_list) LIKE "%z... | [{'UUID': 'DrugTargetsIndication121923_text_1025162', 'drugName': 'Zanubrutinib', 'tradeNames_list': "['Brukinsa']", 'syns_list': "['BGB-3111', 'Bgb-3111', 'Zanubrutinib']", 'target': 'ENSG00000010671', 'approvedSymbol': 'BTK', 'approvedName': 'Bruton tyrosine kinase', 'mesh_heading': 'Lupus Nephritis', 'efo_term': 'lu... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.712 | Q6 | What genes does Epinephrine target when it's used to treat asthma? | When used to treat asthma, the drug Epinephrine targets the genes ADRA1A, ADRB2, ADRB1, ADRB3, ADRA1D, ADRA1B, ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%epinephrine%" OR LOWER(tradeNames_list) LIKE "%ep... | [{'UUID': 'DrugTargetsIndication121923_text_360942', 'drugName': 'Epinephrine', 'tradeNames_list': "['Adren co', 'Adrenaclick', 'Adrenalin', 'Ana-Kit', 'Ana-guard', 'AnapenAnaphylactic shock drug kit', 'Asma-vydrin', 'Asthmahaler', 'Auvi-qBronkaid mist', 'Brovon', 'Emerade', 'Epi e z pen jr', 'EpinephrineEpinephrine (c... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1383 | Q6 | What genes does Bortezomib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Bortezomib targets the genes PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSMB3, PSMB4, PSMB7, ADRM1, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD3, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PS... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bortezomib%" OR LOWER(tradeNames_list) LIKE "%bor... | [{'UUID': 'DrugTargetsIndication121923_text_345245', 'drugName': 'Bortezomib', 'tradeNames_list': "['Velcade']", 'syns_list': "['Bortezomib', 'Bortezomib accord', 'Bortezomib hydrate', 'LDP-341NSC-681239', 'PS-341', 'Velcade']", 'target': 'ENSG00000129084', 'approvedSymbol': 'PSMA1', 'approvedName': 'proteasome 20S sub... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1329 | Q6 | What genes does Propranolol Hydrochloride target when it's used to treat coronary atherosclerosis? | When used to treat coronary atherosclerosis, the drug Propranolol Hydrochloride targets the genes ADRB2 and ADRB1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%propranolol hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_937046', 'drugName': 'Propranolol Hydrochloride', 'tradeNames_list': "['Angilol', 'Apsolol', 'Avlocardyl', 'Bedranol', 'Bedranol s.r.', 'BerkololBeta-prograne mr', 'Betadur cr', 'Cardinol', 'DupromexHalf beta-prograne mr', 'Half propanix la', 'Half propatard laHalf-beprane cr... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.624 | Q6 | What genes does Azacitidine target when it's used to treat cancer? | When used to treat cancer, the drug Azacitidine targets the genes DNMT1 and DNMT3A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%azacitidine%" OR LOWER(tradeNames_list) LIKE "%az... | [{'UUID': 'DrugTargetsIndication121923_text_1192102', 'drugName': 'Azacitidine', 'tradeNames_list': "['Azacitidine', 'Onureg', 'Vidaza']", 'syns_list': "['5-azacitidine', 'Azacitidine', 'Ladakamycin', 'NSC-102816', 'U-18,496U-18496', 'Vidaza']", 'target': 'ENSG00000119772', 'approvedSymbol': 'DNMT3A', 'approvedName': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1464 | Q6 | What genes does Olopatadine Hydrochloride target when it's used to treat Pruritus? | When used to treat Pruritus, the drug Olopatadine Hydrochloride targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%olopatadine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_455972', 'drugName': 'Olopatadine Hydrochloride', 'tradeNames_list': "['Olopatadine hydrochloride', 'Pataday', 'Pataday once daily reliefPataday twice daily relief', 'Patanase', 'Patanol', 'Pazeo']", 'syns_list': "['ALO-4943A', 'ALO4943A', 'Allelock', 'KW-4679', 'KW4679Olopat... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1556 | Q6 | What genes does Brexanolone target when it's used to treat postpartum depression? | When used to treat postpartum depression, the drug Brexanolone targets the genes GABRA1, GABRB2, GABRG2, GABRB3, GABRA4, GABRG3, GABRQ, GABRA3, GABRP, GABRD, GABRG1, GABRB1, GABRE, GABRA2, GABRA5, and GABRA6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%brexanolone%" OR LOWER(tradeNames_list) LIKE "%br... | [{'UUID': 'DrugTargetsIndication121923_text_966482', 'drugName': 'Brexanolone', 'tradeNames_list': "['Zulresso']", 'syns_list': "['Allopregnan-3.alpha.-ol-20-one', 'AllopregnanoloneAllotetrahydroprogesterone', 'Brexanolone', 'SAGE-547', 'SGE-102']", 'target': 'ENSG00000022355', 'approvedSymbol': 'GABRA1', 'approvedName... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.708 | Q6 | What genes does Lidocaine target when it's used to treat inflammation? | When used to treat inflammation, the drug Lidocaine targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lidocaine%" OR LOWER(tradeNames_list) LIKE "%lido... | [{'UUID': 'DrugTargetsIndication121923_text_638355', 'drugName': 'Lidocaine', 'tradeNames_list': "['Alphacaine', 'Anestacon', 'Dentipatch', 'Lidocaine', 'LidodermLignocaine Hcl', 'Lignostab', 'Lmx 4', 'Oraqix', 'Vagisil', 'XylocaineXylodase', 'Xylotox', 'Ztlido']", 'syns_list': "['ALGRX 3268', 'ALGRX-3268', 'Anestacon'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1928 | Q6 | What genes does Dextroamphetamine target when it's used to treat drug dependence? | When used to treat drug dependence, the drug Dextroamphetamine targets the genes SLC6A2, SLC18A2, and SLC6A3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dextroamphetamine%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_418425', 'drugName': 'Dextroamphetamine', 'tradeNames_list': "['Dexedrine', 'Dextrostat', 'Xelstrym']", 'syns_list': "['Amfetamine, (s)-', 'Amphetamine, d-', 'D-amphetamine', 'DexamfetamineDexampex', 'Dexamphetamine', 'Dexedrine', 'Dexidrine', 'DextroamphetamineDextroamphetam... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.614 | Q6 | What genes does Fosaprepitant Dimeglumine target when it's used to treat Nausea and vomiting? | When used to treat Nausea and vomiting, the drug Fosaprepitant Dimeglumine targets the gene TACR1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fosaprepitant dimeglumine%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_1073161', 'drugName': 'Fosaprepitant Dimeglumine', 'tradeNames_list': "['Emend', 'Fosaprepitant dimeglumine']", 'syns_list': "['Fosaprepitant (as dimeglumine)', 'Fosaprepitant dimeglumineFosaprepitant meglumine', 'MK-0517']", 'target': 'ENSG00000115353', 'approvedSymbol': 'TA... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.372 | Q6 | What genes does Palbociclib target when it's used to treat head and neck malignant neoplasia? | Palbociclib has not been approved by the FDA as a treatment for head and neck malignant neoplasia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CDK4, CDK6, and CCND1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%palbociclib%" OR LOWER(tradeNames_list) LIKE "%pa... | [{'UUID': 'DrugTargetsIndication121923_text_851545', 'drugName': 'Palbociclib', 'tradeNames_list': "['Ibrance']", 'syns_list': "['PD-0332991', 'Palbociclib']", 'target': 'ENSG00000135446', 'approvedSymbol': 'CDK4', 'approvedName': 'cyclin dependent kinase 4', 'mesh_heading': 'Head and Neck Neoplasms', 'efo_term': 'head... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1756 | Q6 | What genes does Beclomethasone Dipropionate target when it's used to treat allergic rhinitis? | When used to treat allergic rhinitis, the drug Beclomethasone Dipropionate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%beclomethasone dipropionate%" OR LOWER(tradeNames... | [{'UUID': 'DrugTargetsIndication121923_text_220953', 'drugName': 'Beclomethasone Dipropionate', 'tradeNames_list': "['Aerobec 100', 'Aerobec 50', 'Aerobec fte 250', 'Asmabec clickhalerAsmabec spacehaler', 'Beclazone 100', 'Beclazone 100 e-breatheBeclazone 200', 'Beclazone 250', 'Beclazone 250 e-breathe', 'Beclazone 50B... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1669 | Q6 | What genes does Methotrexate target when it's used to treat unspecified peripheral T-cell lymphoma? | Methotrexate has not been approved by the FDA as a treatment for unspecified peripheral T-cell lymphoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%methotrexate%" OR LOWER(tradeNames_list) LIKE "%m... | [{'UUID': 'DrugTargetsIndication121923_text_1057455', 'drugName': 'Methotrexate', 'tradeNames_list': "['Amethopterin', 'Ebetrex', 'Emtexate high-pot', 'Emtexate pf', 'FolexMaxtrex', 'Methotrexate', 'Metoject', 'Mexate', 'Otrexup', 'Otrexup pfsRasuvo', 'Reditrex', 'Rheumatrex', 'Trexall', 'Zlatal']", 'syns_list': "['(r)... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.533 | Q6 | What genes does Gemcitabine Hydrochloride target when it's used to treat breast cancer? | When used to treat breast cancer, the drug Gemcitabine Hydrochloride targets the genes POLA1, POLD4, POLD3, POLD1, POLD2, POLE, POLA2, PRIM1, PRIM2, POLE2, POLE3, RRM1, RRM2B, and RRM2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%gemcitabine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_760122', 'drugName': 'Gemcitabine Hydrochloride', 'tradeNames_list': "['Gemcitabine hydrochloride', 'Gemzar', 'Infugem']", 'syns_list': "['Gemcitabine (as hydrochloride)', 'Gemcitabine hclGemcitabine hydrochloride', 'Gemzar', 'LY-188011LY-188011 HYDROCHLORIDE', 'LY188011 HYDR... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1821 | Q6 | What genes does Erdafitinib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Erdafitinib targets the genes FGFR1, FGFR3, FGFR2, and FGFR4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%erdafitinib%" OR LOWER(tradeNames_list) LIKE "%er... | [{'UUID': 'DrugTargetsIndication121923_text_707253', 'drugName': 'Erdafitinib', 'tradeNames_list': "['Balversa']", 'syns_list': "['Erdafitinib', 'JNJ-42756493', 'Jnj-42756493']", 'target': 'ENSG00000077782', 'approvedSymbol': 'FGFR1', 'approvedName': 'fibroblast growth factor receptor 1', 'mesh_heading': 'Neoplasms', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1442 | Q6 | What genes does Aripiprazole target when it's used to treat schizophrenia? | When used to treat schizophrenia, the drug Aripiprazole targets the genes DRD2, HTR2A, and HTR1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%aripiprazole%" OR LOWER(tradeNames_list) LIKE "%a... | [{'UUID': 'DrugTargetsIndication121923_text_158031', 'drugName': 'Aripiprazole Lauroxil', 'tradeNames_list': "['Aristada', 'Aristada initio kit']", 'syns_list': "['ALKS 9072', 'ALKS-9070', 'ALKS-9072', 'Aripiprazole lauroxilAristada initio', 'RDC-3317', 'RDC3317']", 'target': 'ENSG00000149295', 'approvedSymbol': 'DRD2'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.302 | Q6 | What genes does Bupropion Hydrobromide target when it's used to treat unipolar depression? | When used to treat unipolar depression, the drug Bupropion Hydrobromide targets the genes SLC6A2 and SLC6A3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bupropion hydrobromide%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_434149', 'drugName': 'Bupropion Hydrobromide', 'tradeNames_list': "['Aplenzin']", 'syns_list': "['BVF-033', 'Bupropion hbr', 'Bupropion hydrobromide']", 'target': 'ENSG00000103546', 'approvedSymbol': 'SLC6A2', 'approvedName': 'solute carrier family 6 member 2', 'mesh_heading'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1016 | Q6 | What genes does Vandetanib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Vandetanib targets the genes EGFR, ERBB3, KDR, SRC, TEK, ERBB2, FLT1, FLT4, EPHA2, RET, ERBB4, EPHB4, PTK6, EPHB2, EPHA5, EPHA4, EPHA8, EPHA6, EPHA7, EPHB3, EPHA3, EPHB1, EPHA1, EPHB6, and EPHA10. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%vandetanib%" OR LOWER(tradeNames_list) LIKE "%van... | [{'UUID': 'DrugTargetsIndication121923_text_210524', 'drugName': 'Vandetanib', 'tradeNames_list': "['Caprelsa', 'Zactima']", 'syns_list': "['GNF-PF-2188', 'NSC-744325', 'NSC-760766', 'Vandetanib', 'ZD-64', 'ZD-6474ZD6474']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert domain rec... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
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