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  1. .gitattributes +22 -0
  2. ABCA1 activity is associated with reduced Alzheimer’s Disease risk in APOE ε4 non-carriers .pdf +3 -0
  3. ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease .html +926 -0
  4. ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease .pdf +3 -0
  5. APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia .pdf +3 -0
  6. APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease.pdf +3 -0
  7. APOE4:4 is linked to damaging lipid droplets in Alzheimer’s microglia .pdf +3 -0
  8. Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice .pdf +3 -0
  9. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE:Aβ association in physiological conditions .pdf +3 -0
  10. ApoE4 Accelerates Early Seeding of Amyloid Pathology .html +926 -0
  11. ApoE4 Accelerates Early Seeding of Amyloid Pathology .pdf +3 -0
  12. ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes.pdf +2 -2
  13. Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid .pdf +3 -0
  14. Apolipoprotein E aggregation in microglia, seeds β-amyloidosis in Alzheimer’s disease .pdf +3 -0
  15. Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease .pdf +3 -0
  16. Apolipoprotein E4 in Alzheimer’s Disease- Role in Pathology, Lipid Metabolism, and Drug Treatment .pdf +3 -0
  17. Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age† .pdf +3 -0
  18. Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD .pdf +3 -0
  19. Central Nervous System Lipoproteins- ApoE and Regulation of Cholesterol Metabolism .pdf +3 -0
  20. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia .pdf +3 -0
  21. Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease .pdf +3 -0
  22. Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance .pdf +3 -0
  23. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. .pdf +3 -0
  24. Lipidome and Proteome of Astrocyte and Microglia ApoE Lipoprotein Reveal Differences Based on Cell Type and ApoE Isoform .pdf +3 -0
  25. Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease- a rationale for multi-nutrient dementia prevention- Thematic Review Series- ApoE and Lipid Homeostasis in Alzheimer's Disease .pdf +3 -0
  26. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease .pdf +3 -0
.gitattributes CHANGED
@@ -71,3 +71,25 @@ Differential[[:space:]]Effects[[:space:]]of[[:space:]]apoE4[[:space:]]and[[:spac
71
  Liver[[:space:]]X[[:space:]]receptor[[:space:]]agonist[[:space:]]treatment[[:space:]]significantly[[:space:]]affects[[:space:]]phenotype[[:space:]]and[[:space:]]transcriptome[[:space:]]of[[:space:]]APOE3[[:space:]]and[[:space:]]APOE4[[:space:]]Abca1[[:space:]]haplo-deficient[[:space:]]mice.pdf filter=lfs diff=lfs merge=lfs -text
72
  Molecular[[:space:]]interactions[[:space:]]between[[:space:]]apoE[[:space:]]and[[:space:]]ABCA1-[[:space:]]impact[[:space:]]on[[:space:]]apoE[[:space:]]lipidation[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
73
  The[[:space:]]role[[:space:]]of[[:space:]]ATP-binding[[:space:]]cassette[[:space:]]subfamily[[:space:]]A[[:space:]]in[[:space:]]the[[:space:]]etiology[[:space:]]of[[:space:]]Alzheimer’s[[:space:]]disease.pdf filter=lfs diff=lfs merge=lfs -text
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
71
  Liver[[:space:]]X[[:space:]]receptor[[:space:]]agonist[[:space:]]treatment[[:space:]]significantly[[:space:]]affects[[:space:]]phenotype[[:space:]]and[[:space:]]transcriptome[[:space:]]of[[:space:]]APOE3[[:space:]]and[[:space:]]APOE4[[:space:]]Abca1[[:space:]]haplo-deficient[[:space:]]mice.pdf filter=lfs diff=lfs merge=lfs -text
72
  Molecular[[:space:]]interactions[[:space:]]between[[:space:]]apoE[[:space:]]and[[:space:]]ABCA1-[[:space:]]impact[[:space:]]on[[:space:]]apoE[[:space:]]lipidation[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
73
  The[[:space:]]role[[:space:]]of[[:space:]]ATP-binding[[:space:]]cassette[[:space:]]subfamily[[:space:]]A[[:space:]]in[[:space:]]the[[:space:]]etiology[[:space:]]of[[:space:]]Alzheimer’s[[:space:]]disease.pdf filter=lfs diff=lfs merge=lfs -text
74
+ ABCA1[[:space:]]activity[[:space:]]is[[:space:]]associated[[:space:]]with[[:space:]]reduced[[:space:]]Alzheimer’s[[:space:]]Disease[[:space:]]risk[[:space:]]in[[:space:]]APOE[[:space:]]ε4[[:space:]]non-carriers[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
75
+ ABCA1-[[:space:]]and[[:space:]]ABCG1-mediated[[:space:]]cholesterol[[:space:]]efflux[[:space:]]capacity[[:space:]]of[[:space:]]cerebrospinal[[:space:]]fluid[[:space:]]is[[:space:]]impaired[[:space:]]in[[:space:]]Alzheimer's[[:space:]]disease[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
76
+ APOE4[[:space:]]disrupts[[:space:]]intracellular[[:space:]]lipid[[:space:]]homeostasis[[:space:]]in[[:space:]]human[[:space:]]iPSC-derived[[:space:]]glia[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
77
+ APOE4[[:space:]]homozygosity[[:space:]]represents[[:space:]]a[[:space:]]distinct[[:space:]]genetic[[:space:]]form[[:space:]]of[[:space:]]Alzheimer’s[[:space:]]disease.pdf filter=lfs diff=lfs merge=lfs -text
78
+ APOE4:4[[:space:]]is[[:space:]]linked[[:space:]]to[[:space:]]damaging[[:space:]]lipid[[:space:]]droplets[[:space:]]in[[:space:]]Alzheimer’s[[:space:]]microglia[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
79
+ Abca1[[:space:]]Deficiency[[:space:]]Affects[[:space:]]Alzheimer's[[:space:]]Disease-Like[[:space:]]Phenotype[[:space:]]in[[:space:]]Human[[:space:]]ApoE4[[:space:]]But[[:space:]]Not[[:space:]]in[[:space:]]ApoE3-Targeted[[:space:]]Replacement[[:space:]]Mice[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
80
+ ApoE[[:space:]]influences[[:space:]]amyloid-β[[:space:]](Aβ)[[:space:]]clearance[[:space:]]despite[[:space:]]minimal[[:space:]]apoE:Aβ[[:space:]]association[[:space:]]in[[:space:]]physiological[[:space:]]conditions[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
81
+ ApoE4[[:space:]]Accelerates[[:space:]]Early[[:space:]]Seeding[[:space:]]of[[:space:]]Amyloid[[:space:]]Pathology[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
82
+ Apolipoprotein[[:space:]]E[[:space:]]Genotype[[:space:]]Affects[[:space:]]Size[[:space:]]of[[:space:]]ApoE[[:space:]]Complexes[[:space:]]in[[:space:]]Cerebrospinal[[:space:]]Fluid[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
83
+ Apolipoprotein[[:space:]]E[[:space:]]aggregation[[:space:]]in[[:space:]]microglia,[[:space:]]seeds[[:space:]]β-amyloidosis[[:space:]]in[[:space:]]Alzheimer’s[[:space:]]disease[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Apolipoprotein[[:space:]]E[[:space:]]ε4[[:space:]]and[[:space:]]age[[:space:]]effects[[:space:]]on[[:space:]]florbetapir[[:space:]]positron[[:space:]]emission[[:space:]]tomography[[:space:]]in[[:space:]]healthy[[:space:]]aging[[:space:]]and[[:space:]]Alzheimer[[:space:]]disease[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Apolipoprotein[[:space:]]E4[[:space:]]in[[:space:]]Alzheimer’s[[:space:]]Disease-[[:space:]]Role[[:space:]]in[[:space:]]Pathology,[[:space:]]Lipid[[:space:]]Metabolism,[[:space:]]and[[:space:]]Drug[[:space:]]Treatment[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Apolipoprotein[[:space:]]E–dependent[[:space:]]accumulation[[:space:]]of[[:space:]]Alzheimer[[:space:]]disease–related[[:space:]]lesions[[:space:]]begins[[:space:]]in[[:space:]]middle[[:space:]]age†[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Cellular[[:space:]]senescence[[:space:]]induced[[:space:]]by[[:space:]]cholesterol[[:space:]]accumulation[[:space:]]is[[:space:]]mediated[[:space:]]by[[:space:]]lysosomal[[:space:]]ABCA1[[:space:]]in[[:space:]]APOE4[[:space:]]and[[:space:]]AD[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Central[[:space:]]Nervous[[:space:]]System[[:space:]]Lipoproteins-[[:space:]]ApoE[[:space:]]and[[:space:]]Regulation[[:space:]]of[[:space:]]Cholesterol[[:space:]]Metabolism[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Cholesterol[[:space:]]and[[:space:]]matrisome[[:space:]]pathways[[:space:]]dysregulated[[:space:]]in[[:space:]]astrocytes[[:space:]]and[[:space:]]microglia[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Fibrillar[[:space:]]amyloid-β[[:space:]]burden[[:space:]]in[[:space:]]cognitively[[:space:]]normal[[:space:]]people[[:space:]]at[[:space:]]3[[:space:]]levels[[:space:]]of[[:space:]]genetic[[:space:]]risk[[:space:]]for[[:space:]]Alzheimer's[[:space:]]disease[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Human[[:space:]]apoE[[:space:]]Isoforms[[:space:]]Differentially[[:space:]]Regulate[[:space:]]Brain[[:space:]]Amyloid-β[[:space:]]Peptide[[:space:]]Clearance[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Increased[[:space:]]amyloid[[:space:]]beta-peptide[[:space:]]deposition[[:space:]]in[[:space:]]cerebral[[:space:]]cortex[[:space:]]as[[:space:]]a[[:space:]]consequence[[:space:]]of[[:space:]]apolipoprotein[[:space:]]E[[:space:]]genotype[[:space:]]in[[:space:]]late-onset[[:space:]]Alzheimer[[:space:]]disease.[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Lipidome[[:space:]]and[[:space:]]Proteome[[:space:]]of[[:space:]]Astrocyte[[:space:]]and[[:space:]]Microglia[[:space:]]ApoE[[:space:]]Lipoprotein[[:space:]]Reveal[[:space:]]Differences[[:space:]]Based[[:space:]]on[[:space:]]Cell[[:space:]]Type[[:space:]]and[[:space:]]ApoE[[:space:]]Isoform[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Omega-3[[:space:]]fatty[[:space:]]acids,[[:space:]]lipids,[[:space:]]and[[:space:]]apoE[[:space:]]lipidation[[:space:]]in[[:space:]]Alzheimer's[[:space:]]disease-[[:space:]]a[[:space:]]rationale[[:space:]]for[[:space:]]multi-nutrient[[:space:]]dementia[[:space:]]prevention-[[:space:]]Thematic[[:space:]]Review[[:space:]]Series-[[:space:]]ApoE[[:space:]]and[[:space:]]Lipid[[:space:]]Homeostasis[[:space:]]in[[:space:]]Alzheimer's[[:space:]]Disease[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
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+ Overexpression[[:space:]]of[[:space:]]ABCA1[[:space:]]reduces[[:space:]]amyloid[[:space:]]deposition[[:space:]]in[[:space:]]the[[:space:]]PDAPP[[:space:]]mouse[[:space:]]model[[:space:]]of[[:space:]]Alzheimer[[:space:]]disease[[:space:]].pdf filter=lfs diff=lfs merge=lfs -text
ABCA1 activity is associated with reduced Alzheimer’s Disease risk in APOE ε4 non-carriers .pdf ADDED
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+ <div class="hor-line" style="border-color:#e9711c"></div><div class="panel-s u-padding-l-bottom u-bg-white u-clr-grey7" role="contentinfo"><a class="anchor move-left els-footer-elsevier anchor-has-inherit-color" href="https://www.elsevier.com/" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text"><img src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/67/images/wordmark-elsevier.svg" height="30" width="104" alt="Elsevier"></span></a><div class="panel-s u-bg-white u-padding-0-hor-from-xs u-padding-s-hor-from-md u-padding-xs-ver text-xs u-clear-both-from-xs u-clear-none-from-md"><p class="u-margin-xs-bottom"><a class="anchor u-margin-xs-right u-margin-s-right-from-sm u-margin-l-right-from-md anchor-has-inherit-color" href="https://www.elsevier.com/solutions/sciencedirect" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text">About ScienceDirect</span></a><wbr><a class="anchor u-margin-xs-right u-margin-s-right-from-sm u-margin-l-right-from-md anchor-has-inherit-color" href="https://www.sciencedirect.com/user/institution/login?targetURL=%2F" id="els-footer-remote-access" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text">Remote access</span></a><wbr><a class="anchor u-margin-xs-right u-margin-s-right-from-sm u-margin-l-right-from-md anchor-has-inherit-color" href="https://service.elsevier.com/app/contact/supporthub/sciencedirect/" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text">Contact and support</span></a><wbr><a class="anchor u-margin-xs-right u-margin-s-right-from-sm u-margin-l-right-from-md anchor-has-inherit-color" href="https://www.elsevier.com/legal/elsevier-website-terms-and-conditions" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text">Terms and conditions</span></a><wbr><a class="anchor u-margin-xs-right u-margin-s-right-from-sm u-margin-l-right-from-md anchor-has-inherit-color" href="https://www.elsevier.com/legal/privacy-policy" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text">Privacy policy</span></a><wbr><a class="anchor u-margin-xs-right u-margin-s-right-from-sm u-margin-l-right-from-md anchor-has-inherit-color" href="https://www.elsevier.com/legal/cookienotice" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text">Cookie settings</span></a></p>
686
+ <p id="els-footer-copyright">All content on this site: Copyright © <!-- -->2025<!-- --> Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.</p>
687
+ </div><div><span style="margin-top:-10px" class="u-position-relative move-bottom u-float-left-from-xs u-float-right-from-md move-right u-padding-0-hor"><a class="anchor els-footer-relx anchor-has-inherit-color" href="https://www.relx.com/" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text"><img src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/67/images/wordmark-relx-group.svg" height="28" width="118" alt="RELX group home page"></span></a></span></div></div>
688
+ </div>
689
+ </footer>
690
+ </div>
691
+
692
+ <script>
693
+ function unhideImages() {
694
+ var images = document.getElementsByClassName("lazyimg");
695
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696
+ if (
697
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698
+ images[i].id !== "oldchallpx" &&
699
+ images[i].id !== "errorchallpx" &&
700
+ images[i].id !== "initerrorchallpx"
701
+ ) {
702
+ var imagelink = images[i].getAttribute("data-src");
703
+ images[i].setAttribute("src", imagelink);
704
+ }
705
+ }
706
+ }
707
+
708
+ function unhideSpecificImage(id) {
709
+ var images = document.getElementsByClassName("lazyimg");
710
+ for (var i = 0; i < images.length; i++) {
711
+ if (images[i].id === id) {
712
+ var imagelink = images[i].getAttribute("data-src");
713
+ images[i].setAttribute("src", imagelink);
714
+ }
715
+ }
716
+ }
717
+
718
+ function unhideFailedClientSideImage() {
719
+ unhideSpecificImage("failedcschallpx")
720
+ }
721
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722
+ function unhideFailedInitialisationImage() {
723
+ unhideSpecificImage("initerrorchallpx")
724
+ }
725
+
726
+ function unhideOldImage() {
727
+ unhideSpecificImage("oldchallpx")
728
+ }
729
+
730
+ function unhideFailedClientSideWithErrorImage() {
731
+ unhideSpecificImage("errorchallpx")
732
+ }
733
+
734
+ function unhideBrowserSupport() {
735
+ unhideOldImage();
736
+ var challenge = document.querySelector(".challenge");
737
+ challenge.classList.add("hidden");
738
+
739
+ var challenge = document.querySelector(".oldbrowserproblem");
740
+ challenge.classList.remove("hidden");
741
+ }
742
+
743
+ function unhideProblemCreationIssue(err) {
744
+ window['initialisationFailed'] = true;
745
+ unhideFailedInitialisationImage();
746
+
747
+ // grab problem div
748
+ var problem = document.querySelector(".challenge");
749
+ var title = problem.querySelector(".title")
750
+ title.innerHTML="Request Verification: Initialisation Error";
751
+
752
+ var form = document.querySelector(".captcha-form");
753
+ form.classList.add("hidden");
754
+
755
+ if (err !== null && err !== undefined) {
756
+ var errStack = document.querySelector("#errstack");
757
+
758
+ // hide it
759
+ errStack.classList.remove("hidden");
760
+
761
+ var browserError = document.querySelector(".browsererror");
762
+ browserError.innerHTML = "" + err;
763
+ }
764
+
765
+ if (window['scriptloaderror']) {
766
+ document.querySelector("#browsersupport").classList.remove("hidden");
767
+ }
768
+ }
769
+
770
+ function unhideClientErrors() {
771
+ var clienterror = document.querySelector("#clienterror")
772
+ clienterror.innerHTML="<strong>Error(s)</strong>: " + window['turnstileClientErrors'].toString() + "<br/>"
773
+ clienterror.classList.remove("hidden");
774
+ }
775
+
776
+ function unhideChallenge() {
777
+ var challenge = document.querySelector(".challenge");
778
+ challenge.style.display = "block"
779
+ }
780
+
781
+ function unhideProblem(err) {
782
+ if (window['turnstileClientErrors'].length > 0) {
783
+ console.log(window['turnstileClientErrors'])
784
+ unhideClientErrors()
785
+ }
786
+ // grab problem div
787
+ var problem = document.querySelector(".challenge");
788
+ var title = problem.querySelector(".title")
789
+ if (err===null && err === undefined) {
790
+ title.innerHTML="Request Verification: Failed";
791
+ } else {
792
+ title.innerHTML="Request Verification: Error";
793
+ }
794
+
795
+ if (err !== null && err !== undefined) {
796
+ unhideFailedClientSideWithErrorImage();
797
+ var errStack = document.querySelector("#errstack");
798
+
799
+ // hide it
800
+ errStack.classList.remove("hidden");
801
+
802
+ var browserError = document.querySelector(".browsererror");
803
+ browserError.innerHTML = "" + err;
804
+ } else {
805
+ unhideFailedClientSideImage();
806
+ }
807
+ }
808
+
809
+ function unhideCss() {
810
+ var styleCSS = document.createElement("link");
811
+ styleCSS.rel = "stylesheet";
812
+ // eslint-disable-next-line
813
+ styleCSS.href = "https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/108/css/react-header-and-footer/21.0.3/styles.css";
814
+ // eslint-disable-next-line
815
+ var styles = ".els-row-center,.els-row-center-fixed,.els-row-content{margin-left:auto;margin-right:auto}@font-face{font-family:NexusSans;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-Regular.woff) format('woff')}@font-face{font-family:NexusSans;font-weight:700;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-Bold.woff) format('woff')}@font-face{font-family:NexusSans;font-style:italic;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-Italic.woff) format('woff')}@font-face{font-family:NexusSans;font-style:italic;font-weight:700;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-BoldItalic.woff) 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816
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817
+ styleSheet.innerText = styles;
818
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819
+ document.head.appendChild(styleSheet);
820
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821
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822
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823
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824
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825
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826
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827
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828
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829
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830
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831
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832
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833
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834
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835
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836
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837
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838
+ window['turnstileRetry'] = window['turnstileRetry'] + 1
839
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840
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841
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842
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843
+ } else {
844
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845
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846
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847
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848
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849
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850
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851
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852
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853
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854
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855
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856
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858
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859
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861
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862
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864
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865
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866
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867
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868
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869
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870
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871
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872
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873
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874
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875
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876
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877
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878
+ setTimeout( function () {
879
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880
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881
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882
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883
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884
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885
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886
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887
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888
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889
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890
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891
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892
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893
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894
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895
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896
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897
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898
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899
+ turnstile.execute();
900
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901
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902
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903
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904
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905
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906
+ unhideCss();
907
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908
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909
+ window['initialisationFailed'] = false;
910
+ window['turnstileComplete'] = false;
911
+ window['turnstileClientErrors'] = [];
912
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913
+ if(window.isIE) {
914
+ unhideBrowserSupport();
915
+ } else {
916
+ unhideChallenge();
917
+ try {
918
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919
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920
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921
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922
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923
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924
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925
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+ line-height: 26px;
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+ .els-row-grey.els-row-center,
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+ .els-row-grey,
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185
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+ padding-left: 8px;
187
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266
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267
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269
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280
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281
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282
+ margin-right: 16.66%;
283
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286
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287
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288
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289
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290
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292
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293
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294
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295
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297
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298
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299
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300
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301
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302
+ padding-top: 17px;
303
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304
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306
+ color: #505050;
307
+ padding: 29px 8px 0;
308
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309
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310
+ .e404-sugg-title {
311
+ padding: 26px 8px 16px;
312
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313
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314
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315
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316
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317
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318
+ line-height: 24px;
319
+ margin: 0 16px 0 -48px;
320
+ padding-top: 4px;
321
+ text-align: center;
322
+ vertical-align: baseline;
323
+ width: 32px;
324
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325
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326
+ padding: 4px;
327
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328
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329
+ padding-right: 44px;
330
+ width: 100%;
331
+ }
332
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333
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334
+ padding-right: 4px;
335
+ width: 52%;
336
+ }
337
+ }
338
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339
+ .qs404-all {
340
+ width: 28%;
341
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342
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344
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345
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346
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347
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348
+ .qs404-author {
349
+ display: inline-block;
350
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351
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352
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353
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354
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355
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356
+ top: 14px;
357
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358
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359
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360
+ padding: 10px 4px;
361
+ position: relative;
362
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363
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364
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365
+ right: 4px;
366
+ top: 4px;
367
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369
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370
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371
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372
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373
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374
+ width: 20%;
375
+ }
376
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377
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378
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379
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380
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381
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382
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383
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384
+ height: 32px;
385
+ line-height: 30px;
386
+ padding: 0 8px 0 6px;
387
+ width: 100%;
388
+ }
389
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390
+ display: none;
391
+ width: 33.333%;
392
+ }
393
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394
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395
+ height: 0;
396
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397
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398
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399
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400
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401
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402
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403
+ position: relative;
404
+ width: 55%;
405
+ }
406
+ }
407
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408
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409
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410
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411
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412
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413
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414
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415
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416
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417
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419
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420
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421
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422
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423
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424
+ display: inline-block;
425
+ }
426
+ }
427
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428
+ display: none;
429
+ width: 100%;
430
+ }
431
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432
+ .qs404-source {
433
+ display: inline-block;
434
+ width: 45%;
435
+ }
436
+ }
437
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438
+ .qs404-source {
439
+ display: inline-block;
440
+ width: 24%;
441
+ }
442
+ }
443
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444
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445
+ background-color: #007398;
446
+ border: 0;
447
+ color: #fff;
448
+ height: 32px;
449
+ width: 32px;
450
+ }
451
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452
+ position: absolute;
453
+ left: 4px;
454
+ top: 4px;
455
+ }
456
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457
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458
+ border: 0;
459
+ color: #505050;
460
+ display: block;
461
+ margin-top: -10px;
462
+ height: 28px;
463
+ padding: 0 0 4px;
464
+ width: 100%;
465
+ }
466
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467
+ -webkit-transform: rotate(-90deg);
468
+ transform: rotate(-90deg);
469
+ }
470
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471
+ -webkit-transform: rotate(90deg);
472
+ transform: rotate(90deg);
473
+ }
474
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475
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476
+ width: 33.333%;
477
+ }
478
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479
+ .qs404-toggle {
480
+ display: none;
481
+ }
482
+ .qs404-volume {
483
+ display: inline-block;
484
+ }
485
+ }
486
+
487
+ </style>
488
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489
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490
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491
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493
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495
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496
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497
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498
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500
+ }
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502
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503
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504
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506
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507
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508
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509
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511
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512
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513
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514
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516
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517
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518
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524
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526
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527
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+ <img class="lazyimg" loading="lazy" id="initerrorchallpx" width="0" height="0" data-src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/88/images/1px.png?fr=cfts_initerror&rr=9d68b54a281e41c3" style="width: 0; height: 0; border: 0; border: none; position: absolute;" alt=""></img>
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+ <p id="els-footer-copyright">All content on this site: Copyright © <!-- -->2025<!-- --> Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.</p>
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+ </div><div><span style="margin-top:-10px" class="u-position-relative move-bottom u-float-left-from-xs u-float-right-from-md move-right u-padding-0-hor"><a class="anchor els-footer-relx anchor-has-inherit-color" href="https://www.relx.com/" rel="nofollow" target="_blank" style="white-space:nowrap"><span class="anchor-text"><img src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/67/images/wordmark-relx-group.svg" height="28" width="118" alt="RELX group home page"></span></a></span></div></div>
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+ images[i].setAttribute("src", imagelink);
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+ images[i].setAttribute("src", imagelink);
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+ }
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+ }
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+ }
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+
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+ function unhideFailedClientSideImage() {
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+ unhideSpecificImage("failedcschallpx")
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+ }
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+ function unhideFailedInitialisationImage() {
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+ }
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+
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+ function unhideOldImage() {
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+ unhideSpecificImage("oldchallpx")
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+ }
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+
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+ function unhideFailedClientSideWithErrorImage() {
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+ unhideSpecificImage("errorchallpx")
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+ }
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+
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+ function unhideBrowserSupport() {
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+ unhideOldImage();
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+ var challenge = document.querySelector(".challenge");
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+ challenge.classList.add("hidden");
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+
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+ var challenge = document.querySelector(".oldbrowserproblem");
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+ challenge.classList.remove("hidden");
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+ }
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+
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+ function unhideProblemCreationIssue(err) {
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+ window['initialisationFailed'] = true;
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+ unhideFailedInitialisationImage();
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+
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+ // grab problem div
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+ var problem = document.querySelector(".challenge");
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+ var title = problem.querySelector(".title")
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+
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+ form.classList.add("hidden");
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+ var errStack = document.querySelector("#errstack");
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+
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+ // hide it
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+ errStack.classList.remove("hidden");
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+
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+ var browserError = document.querySelector(".browsererror");
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+ browserError.innerHTML = "" + err;
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+ }
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+
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+ if (window['scriptloaderror']) {
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+ document.querySelector("#browsersupport").classList.remove("hidden");
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+ }
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+ }
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+
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+ function unhideClientErrors() {
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+ var clienterror = document.querySelector("#clienterror")
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+ clienterror.innerHTML="<strong>Error(s)</strong>: " + window['turnstileClientErrors'].toString() + "<br/>"
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+ clienterror.classList.remove("hidden");
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+ }
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+
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+ function unhideChallenge() {
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+ var challenge = document.querySelector(".challenge");
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+ challenge.style.display = "block"
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+ }
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+
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+ function unhideProblem(err) {
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+ if (window['turnstileClientErrors'].length > 0) {
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+ console.log(window['turnstileClientErrors'])
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+ unhideClientErrors()
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+ }
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+ // grab problem div
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+ var problem = document.querySelector(".challenge");
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+ if (err===null && err === undefined) {
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+ title.innerHTML="Request Verification: Failed";
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+ } else {
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+ title.innerHTML="Request Verification: Error";
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+
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+ if (err !== null && err !== undefined) {
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+ unhideFailedClientSideWithErrorImage();
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+ var errStack = document.querySelector("#errstack");
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+ // hide it
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+ errStack.classList.remove("hidden");
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+ var browserError = document.querySelector(".browsererror");
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+ browserError.innerHTML = "" + err;
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+ } else {
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+ unhideFailedClientSideImage();
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+ }
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+ }
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+
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+ function unhideCss() {
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+ var styleCSS = document.createElement("link");
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+ styleCSS.rel = "stylesheet";
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+ // eslint-disable-next-line
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+ styleCSS.href = "https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/108/css/react-header-and-footer/21.0.3/styles.css";
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+ // eslint-disable-next-line
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+ var styles = ".els-row-center,.els-row-center-fixed,.els-row-content{margin-left:auto;margin-right:auto}@font-face{font-family:NexusSans;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-Regular.woff) format('woff')}@font-face{font-family:NexusSans;font-weight:700;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-Bold.woff) format('woff')}@font-face{font-family:NexusSans;font-style:italic;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-Italic.woff) format('woff')}@font-face{font-family:NexusSans;font-style:italic;font-weight:700;src:url(//sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/3/fonts/nexus/1.0/sans/NexusSansWebPro-BoldItalic.woff) 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