Upload 3 files

en_val.json

@@ -0,0 +1,841 @@
+[
+    {
+        "text_id": "100376",
+        "sentence_id": 1,
+        "text": "We report a case of a male near-term neonate with gestational age of 35 weeks.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 2,
+        "text": "He was the third born child to a 27-year-old mother with no significant past history.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 3,
+        "text": "He was derived from a third degree consanguineous marriage.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 4,
+        "text": "He was born by means of normal vaginal delivery with a normal extra-uterine adaptation.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 5,
+        "text": "Meconium-stained amniotic fluid was noted.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 6,
+        "text": "His birth weight was 3030g (75 th Percentile).",
+        "relations": [
+            [
+                "3030g",
+                "weight"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 7,
+        "text": "The baby had normal physical examination at birth aside transitory respiratory distress.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 8,
+        "text": "He had been hospitalized for four days in a private clinic, for the suspicion of materno-foetal infection, where he had antibiotics for 48 hours.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 9,
+        "text": "He had developed no symptoms during his hospitalization.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 10,
+        "text": "The output's weight was 2400g which signify the loss of 630g.",
+        "relations": [
+            [
+                "2400g",
+                "weight"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 11,
+        "text": "Back home, he received exclusive maternal breastfeeding.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 12,
+        "text": "On his fifth day of life, he presented multiple yellowish-watery stools (ab 12 times) and refuse feeding with apyrexia context.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 13,
+        "text": "He had clinical signs of severe dehydration without fever or vomiting.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 14,
+        "text": "He lost 930g relative to the birth's weight.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 15,
+        "text": "The abdomen appeared neither tender nor distended, and the rest of his physical examination was normal.",
+        "relations": [
+            [
+                "normal",
+                "examination"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 16,
+        "text": "The laboratory findings revealed hypernatremia of 152mEq/L, hyperkalemia of 7,8mEq/L and severe metabolic acidosis: blood PH: 7,1, HCO3:4mEq/L.",
+        "relations": [
+            [
+                "152mEq/L",
+                "hypernatremia"
+            ],
+            [
+                "7,8mEq/L",
+                "hyperkalemia"
+            ],
+            [
+                "7,1",
+                "PH"
+            ],
+            [
+                "4mEq/L",
+                "HCO3"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 17,
+        "text": "The osmotic gap was 45.",
+        "relations": [
+            [
+                "45",
+                "gap"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 18,
+        "text": "There was no leukocytosis, and the serum level of C-reactive protein was normal.",
+        "relations": [
+            [
+                "normal",
+                "level"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 19,
+        "text": "The infant was treated with intravenous fluids and electrolytes as well as antibiotics after obtaining blood and stool cultures, assuming an infectious etiology.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 20,
+        "text": "After 26 hours of rehydration therapy, the dehydration resolved, however, a functional acute renal failure complicated by acidosis and hyperkalemia appeared.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 21,
+        "text": "The chest radiograph showed \"bat wings\" pattern and the cardiothoracic index was 0, 45.",
+        "relations": [
+            [
+                "0, 45",
+                "index"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 22,
+        "text": "The renal ultrasound showed discretely hyperechoic kidneys cortex and the absence of renal malformations.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 23,
+        "text": "On the 11 th day of life, he was transferred to the pediatric intensive care unit.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 24,
+        "text": "He needed mechanical ventilation for three days and exclusive parenteral feeding by central catheter.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 25,
+        "text": "The evolution was burdened by cholestasis due to the prolonged parenteral feeding and nosocomial infection by staphylococcus epidermidis.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 26,
+        "text": "Since his admission, he had developed a slimy diarrhea with 3 to 4 stools per day.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 27,
+        "text": "He presented a profuse diarrhea during each attempt to introduce enteral feeding by hydrolyzed milk formula.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 28,
+        "text": "He was discharged after 32 days with output's weight 3250g.",
+        "relations": [
+            [
+                "3250g",
+                "weight"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 29,
+        "text": "The oesophago-gastro-duodenoscopy and duodenal biopsy showed partial villous atrophy associated to the brush border abnormalities.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 30,
+        "text": "The periodic acid Schiff (PAS) stain revealed abnormalities in the brush border characterized by loss of the linear part of enterocytes with the presence of intra-cytoplasmic PAS + band in the apical pole of enterocytes uneven thickness and sometimes with double contours pattern.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 31,
+        "text": "In the submucosa, there were numerous Brunner glands.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 32,
+        "text": "We find the existence of numerous hemorrhagic suffusions.",
+        "relations": [
+            [
+                "positive",
+                "immunostain"
+            ]
+        ]
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 33,
+        "text": "The CD10 immunostain was positive.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 34,
+        "text": "Thus, a diagnosis hypothesis of MVID was raised.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 35,
+        "text": "The electron microscopic examination confirmed the diagnosis.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 36,
+        "text": "Mutation analysis of peripheral blood samples of the neonate revealed a mutation at the homozygous status of MYO5B gene.",
+        "relations": []
+    },
+    {
+        "text_id": "100376",
+        "sentence_id": 37,
+        "text": "The baby died, after 97 days of life, of septic shock and multiple organ failure.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 1,
+        "text": "The patient was a 35-year old female who presented with urinary frequency for 2 months.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 2,
+        "text": "Her past medical history showed a nonsmoking history and no significant family history.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 3,
+        "text": "The physical examination was unremarkable.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 4,
+        "text": "She was treated as urinary tract infection, but there was no improvement in her symptoms.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 5,
+        "text": "Urine analysis and culture were performed several times that was negative for infection.",
+        "relations": [
+            [
+                "negative",
+                "infection"
+            ]
+        ]
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 6,
+        "text": "Other laboratory data were also insignificant.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 7,
+        "text": "Through a routine evaluation, urinary system ultrasonography (US) revealed a bladder lesion measuring 7 mm.",
+        "relations": [
+            [
+                "7 mm",
+                "measuring"
+            ]
+        ]
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 8,
+        "text": "In order to confirm the diagnosis, magnetic resonance imaging (MRI) of the abdomen and pelvic cavity was done; it revealed a lesion in the dome of the bladder.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 9,
+        "text": "To confirm the diagnosis and for histopathological examination, the patient underwent Transurethral Resection of Bladder Tumor (TURBT) in April 2018.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 10,
+        "text": "Before starting the procedure, the urethra was dilated till Fr: 28; at first, the tumor location was specified by cystoscopy.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 11,
+        "text": "Then, it was resected by monopolar cautery from superficial to deeper parts with removal of the muscle layers.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 12,
+        "text": "Proper bleeders were taken and three way Foley catheter was applied for a continuous irrigation.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 13,
+        "text": "The patient was transferred to the recovery room with complete stability.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 14,
+        "text": "The histopathology slides show a well-defined mass composed of bland looking spindle cells.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 15,
+        "text": "Subsequent immunohistochemistry (IHC) was done which showed diffuse immunoreactivity for S100, but other markers including smooth muscle actin (SMA), desmin, cytokeratin, CD34 and beta catenin were negative.",
+        "relations": [
+            [
+                "negative",
+                "markers"
+            ],
+            [
+                "negative",
+                "actin"
+            ],
+            [
+                "negative",
+                "CD34"
+            ],
+            [
+                "negative",
+                "desmin"
+            ],
+            [
+                "negative",
+                "SMA"
+            ],
+            [
+                "negative",
+                "cytokeratin"
+            ],
+            [
+                "negative",
+                "catenin"
+            ],
+            [
+                "2-3%",
+                "Ki67"
+            ]
+        ]
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 16,
+        "text": "Ki67 was 2-3%, so the diagnosis of schwannoma was confirmed.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 17,
+        "text": "Then, the neck, abdomen, pelvic and chest computed tomography (CT) scans were done that were normal.",
+        "relations": [
+            [
+                "normal",
+                "scans"
+            ]
+        ]
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 18,
+        "text": "Brain and spine MRI and physical examination showed no evidence of other schwannoma or evidence of neurofibromatosis.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 19,
+        "text": "She had no history of neurofibromatosis in her family.",
+        "relations": []
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 20,
+        "text": "Skin examination was normal and had no café au lait spot.",
+        "relations": [
+            [
+                "normal",
+                "examination"
+            ]
+        ]
+    },
+    {
+        "text_id": "100506",
+        "sentence_id": 21,
+        "text": "She was not a case of von Recklinghausen disease.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 1,
+        "text": "A 12-year-old girl presented an abdominal pain, high persistent fever of (40°C) and severe fatigue.",
+        "relations": [
+            [
+                "40°C",
+                "fever"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 2,
+        "text": "The physical exam revealed pallor, hepatomegaly, and grade III splenomegaly.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 3,
+        "text": "The investigation revealed an elevated white blood cell count (WBC): 545,000/mm³.",
+        "relations": [
+            [
+                "545,000/mm³",
+                "count"
+            ],
+            [
+                "545,000/mm³",
+                "WBC"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 4,
+        "text": "PNN: 49,050/mm³, hemoglobin: 11.6g/dl, platelets: 328,000/mm³.",
+        "relations": [
+            [
+                "49,050/mm³",
+                "PNN"
+            ],
+            [
+                "11.6g/dl",
+                "hemoglobin"
+            ],
+            [
+                "328,000/mm³",
+                "platelets"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 5,
+        "text": "The patient's peripheral blood smear revealed marked leukocytosis with a significant number of immature myeloid precursors and 21% blasts.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 6,
+        "text": "The analysis of the BCR-ABL shows 94% in the peripheral blood.",
+        "relations": [
+            [
+                "94%",
+                "BCR-ABL"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 7,
+        "text": "The patient was diagnosed with CML.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 8,
+        "text": "She received a chemotherapy protocol made of hyperalkalinisation, allopurinol, hydroxyurea and a treatment based on imatinib at the dose of 400mg per day.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 9,
+        "text": "Patient achieved complete hematological remission at three months and complete cytogenetic remission at 12 months.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 10,
+        "text": "The patient was readmitted into our pediatric department with complains of severe headache, vomiting, pain and bilateral visual loss since three days.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 11,
+        "text": "On examination, patient was afebrile and appeared pale.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 12,
+        "text": "Blood pressure was 100/60mm/hg and the heart rate 98 beat/minute.",
+        "relations": [
+            [
+                "100/60mm/hg",
+                "pressure"
+            ],
+            [
+                "98 beat/minute",
+                "rate"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 13,
+        "text": "There was no lymphadenopathy and the nervous system examination was normal.",
+        "relations": [
+            [
+                "normal",
+                "examination"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 14,
+        "text": "Intraocular muscle testing was normal; however, there was an exophthalmia in both eyes.",
+        "relations": [
+            [
+                "normal",
+                "testing"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 15,
+        "text": "The pupil was sluggish to react to light.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 16,
+        "text": "Fundoscopy revealed bilateral stade III disc edema and hemorrhages of the retina.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 17,
+        "text": "She underwent a brain computed tomography (CT) scan with the suspicion of leukemic involvement or any other intracranial event (cerebral edema); however, nothing was found.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 18,
+        "text": "A subsequent bone marrow exam showed no morphologic or molecular evidence of CML or acute leukemia.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 19,
+        "text": "Cytological evaluation of cerebrospinal fluid (CSF) was also negative.",
+        "relations": [
+            [
+                "negative",
+                "evaluation"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 20,
+        "text": "The patient had no other known pathology that could be held responsible for retina edema.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 21,
+        "text": "We suggested that it was a side effect of imatinib so its administration was temporary interrupted.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 22,
+        "text": "The patient was put on an anti-edema therapy (mannitol, dexamethasone).",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 23,
+        "text": "However, few months later, the patient presented in the emergency room with a headache and severe vomiting.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 24,
+        "text": "She described a recurrence of the same character of headaches accompanied with weakness of extremities and seizures.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 25,
+        "text": "Nervous system examination revealed neck rigidity, presence of meningeal signs and lower limb paraplegia.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 26,
+        "text": "CT of the brain revealed subdural chronic hematoma and a serpenginous gyriform enhancement around the contusion in the right parietal and occipital lobes.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 27,
+        "text": "Analysis of the CSF collected showed lymphoblasts in a WBC count of 11000cells/ml.",
+        "relations": [
+            [
+                "11000cells/ml",
+                "lymphoblasts"
+            ],
+            [
+                "11000cells/ml",
+                "count"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 28,
+        "text": "Flow cytometry of the CSF showed that blast cells were positive for a cluster of differentiation markers (CD) (CD34, CD19, CD10, CD22 and partially positive for CD45) confirming CNS extramedullary lymphoid blast infiltration.",
+        "relations": [
+            [
+                "positive",
+                "markers"
+            ],
+            [
+                "partially positive",
+                "CD45"
+            ]
+        ]
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 29,
+        "text": "A bone marrow aspiration was done to evaluate the status of her chronic myelogenous leukemia and result was consistent with a chronic phase.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 30,
+        "text": "Fundus examination showed bilateral optic atrophy.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 31,
+        "text": "The diagnosis of extramedullary isolated CNS blast crises (lymphoid type) was based on the presence of blasts in CSF (confirmed by flow cytometry).",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 32,
+        "text": "The patient received a high-dose systemic induction chemotherapy and intrathecal therapy (methotrexate, arabinoside and dexamethasone).",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 33,
+        "text": "The imatinib was replaced by dasatinib at the dose of 100 mg per day.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 34,
+        "text": "She was treated with 24 Gy of whole-brain radiation therapy.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 35,
+        "text": "Allogenic stem cell transplantation was not feasible.",
+        "relations": []
+    },
+    {
+        "text_id": "100543",
+        "sentence_id": 36,
+        "text": "We noticed a rapidly progressive amelioration in her neurological status after finishing systemic chemotherapy and physical therapy; however, the patient's visual loss showed no signs of improvement.",
+        "relations": []
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 1,
+        "text": "We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in diameter, but was associated with 2 peripancreatic lymph node metastases.",
+        "relations": [
+            [
+                "7 mm",
+                "diameter"
+            ]
+        ]
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 2,
+        "text": "Mild elevation of liver enzymes was found at her regular medical check-up.",
+        "relations": []
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 3,
+        "text": "Computed tomography (CT) revealed a markedly dilated common bile duct (CBD) and two enlarged peripancreatic lymph nodes.",
+        "relations": []
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 4,
+        "text": "Endoscopy showed that the ampulla was slightly enlarged by a submucosal tumor.",
+        "relations": []
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 5,
+        "text": "The biopsy specimen revealed tumor cells that showed monotonous proliferation suggestive of a carcinoid tumor.",
+        "relations": []
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 6,
+        "text": "She underwent a pylorus-preserving whipple resection with lymph node dissection.",
+        "relations": []
+    },
+    {
+        "text_id": "108798",
+        "sentence_id": 7,
+        "text": "The resected lesion was a small submucosal tumor (7 mm in diameter) at the ampulla, with metastasis to 2 peripancreatic lymph nodes, and it was diagnosed as a malignant carcinoid tumor.",
+        "relations": [
+            [
+                "7 mm in diameter",
+                "tumor"
+            ]
+        ]
+    },
+    {
+        "text_id": "101318",
+        "sentence_id": 1,
+        "text": "We observed a 29 y.o. female proband with the episode of venous thrombosis at the age of 18 and family history of thrombosis.",
+        "relations": []
+    },
+    {
+        "text_id": "101318",
+        "sentence_id": 2,
+        "text": "The antithrombin level in our patient was low, 44-48% (AT deficiency type I).",
+        "relations": [
+            [
+                "low",
+                "level"
+            ],
+            [
+                "44-48%",
+                "level"
+            ]
+        ]
+    },
+    {
+        "text_id": "101318",
+        "sentence_id": 3,
+        "text": "A new genetic variant c.662G > C (p.W221S) in the SERPINC1 gene was detected in proband and affected father but was absent in healthy sister.",
+        "relations": []
+    },
+    {
+        "text_id": "101318",
+        "sentence_id": 4,
+        "text": "We used in silico tools to evaluate the possible impact of p.W221S variant on protein structure and function.",
+        "relations": []
+    },
+    {
+        "text_id": "101318",
+        "sentence_id": 5,
+        "text": "In mutated SERPINC1 protein a new N-linked glycosylation site is formed, however, it is unclear if the glycosylation at 219-221 site is possible.",
+        "relations": []
+    }
+]