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329
train_300
By whom is this document written?
['Stacey Dixon Calahan']
train_301
What is the date mentioned?
['January 21, 1999']
train_302
To whom is this document addressed?
['Mr. Larry Ellingson', 'Mr. Ellingson']
train_303
to which department it belongs to ?
['DEPARTMENT OF HEALTH AND HUMAN SERVICES', 'department of health and human services.']
train_304
By whom is this document written?
['Kunio Iwatani']
train_305
what is the date of submission?
['11/18/2002']
train_306
what is the telephone number (include area code)?
['847-383-3739']
train_307
what is the expiration date ?
['November 30, 2002', 'november 30, 2002']
train_308
what is the name of the sponsor ?
['Takeda Pharmaceuticals North America, Inc.', 'Takeda Pharmaceuticals North america , Inc.']
train_309
what has to be investigated before starting pioglitazone therapy?
['any macroscopic haematuria']
train_310
what has been experienced commonly in patients taking actos in combination with insulin?
['Heart failure', 'heart failure']
train_311
Which foundation is mentioned in this document?
['Cleveland Clinic Foundation', 'The Cleveland Clinic Foundation']
train_312
Under which department , The Cleveland Clinic Foundation operates?
['Department of Cardiovascular Medicine', 'Department of Cardiovascular Medicine.']
train_313
What is written in big bold letters at the bottom?
['DALY 19']
train_314
Which medicine is used to treat type 2 diabetes mellitus?
['Actos/Competact']
train_315
How many cases of bladder cancer from 12506 patients were reported?
['19 cases']
train_316
What is the PO Box number?
['931535']
train_317
what is the IND mumber (if previously assigned ) ?
['33,729']
train_318
what is the date of submission ?
['11/1/02']
train_319
what is the Name(s) of drug (include all available names: Trade , Generic, Chemical, Code)?
['ACTOS (pioglitazone HCI)', 'ACTOS (Pioglitazone HCI)']
train_320
What is the Tax ID mentioned in this document?
['34-0714585']
train_321
what is the form approved : OMB No
['0910-0014', '0910-0014.']
train_322
What is the word written in bold on the top of the document?
['Takeda']
train_323
What is the date mentioned?
['19th January 2012']
train_324
what is the name of pharmaceuticals ?
['Takeda Pharmaceuticals North America, Inc.', 'TAkeda pharmaceuticals North America ,INc.']
train_325
to whom this letter is written ?
['Janet L. Haskins', 'janet L. haskins', 'Ms. Haskins']
train_326
When did Regulatory affairs department receive this letter?
['JUN 16 2003']
train_327
To whom was this letter written?
['Healthcare Professional']
train_328
What is the fifth point?
['WAC and AWP generally;', 'WAC AND AWP generally;']
train_329
Education grants regarding which products?
['TPNA', 'TPNA products']
train_330
What is the date this document was last printed?
['11/30/2012', '11/30/2012 4:28:00 AM']
train_331
To whom a copy of cover letter has to be sent ?
['Ms. Jens Weber']
train_332
Which reimbursement for TPNA pharmaceutical products is generally given?
['Medicare and Medicaid']
train_333
What is the designation of Alfonso T. Perez, M.D.?
['Vice President, Clinical Research']
train_334
By whom was this agreement Agreed and Accepted?
['Richard A. Rudick, M.D.', 'Richard A. Rudick, M.D. Chairman, Division of Clinical Research', 'Richard A. Rudick']
train_335
What is the full form of FAR?
['Federal Acquisitions Regulation']
train_336
What is the number written above TAK-INDNDA-01577086?
['425']
train_337
What is the contact number of Ms. Jena Weber, Regulatory Project Manager?
['301-827-6422']
train_338
What is the full form of ODE?
['Office of Drug Evaluation']
train_339
What is written above Page 2 on the top?
['IND 33, 729']
train_340
what is the unit mentioned in the letter ?
['7200']
train_341
Name of the first person in the To list?
['PJ Daniels', 'pj Daniels']
train_342
from whose desk this letter is written ?
['Timothy J. Gumbleton', 'timothy J Gumbleton']
train_343
Whose letter's copy is attached?
['DR. Mitchell', 'Dr. Mitchell']
train_344
what is the date mentioned ?
['February 6, 1996', 'february 6 , 1996']
train_345
to whom this letter is written ?
['Dr. K. KItazawa', 'Dr . k. Kitazawa']
train_346
this letter is written by whom ?
['T. Suzuki', 'Tsuyoshi Suzuki , M S .']
train_347
Which laboratory is T. Suzuki associated with ?
['Drug Safety Research Laboratories', 'drug safety research laboratories .']
train_348
what is the date mentioned in the letter
['August 8, 2002', 'august 8 , 2002']
train_349
What is the name of the industry given here?
['Takeda chemical industries, LTD .', 'TAKEDA CHEMICAL INDUSTRIES, LTD.']
train_350
to whom this letter is written ?
['Dr. Claire Thom', 'Dr. Thom']
train_351
what is the name mentioned in CC
['Mr. S. Hamanaka', 'Mr . S . Hamanaka']
train_352
Who sent this letter?
['Katsuhisa Saito', 'katsuhisa saito']
train_353
what is Ref: code mentioned ?
['TPNA-TS-020808']
train_354
What is the venue mentioned in the document?
['TPNA, Chicago']
train_355
What is the date mentioned in the document?
['Monday, 12 and Tuesday, 13 August 2002']
train_356
what is the fax number mentioned in the letter at the top?
['06 6204 2244']
train_357
what is the date and time mentioned ?
['10/27/93 09:36:07']
train_358
what is mentioned in the subject ?
['Pioglitazone statement', 'pioglitazone statement']
train_359
To whom this email was send?
['PETER J. DANIELS', 'PJ DANIEL--PW17PO PETER J. DANIELS']
train_360
what is the date mentioned in the forwarding note ?
['10/26/93', '10/26/93 15:44']
train_361
what is the time mentioned in the forwarding note ?
['15:44']
train_362
To whom this email was forwaded?
['RUPPEL, PATRICIA', 'PLRUPPEL--RCC1 RUPPEL, PATRICIA']
train_363
what is the name of the company
['THE UPJOHN COMPANY']
train_364
what is the date and year mentioned ?
['September 21, 1993', 'september 21 , 1993']
train_365
Which company is mentioned in the letterhead?
['THE UPJOHN COMPANY']
train_366
in which country the upjohn company is located ?
['U.S.A', 'USA']
train_367
what is the fax mentioned ?
['06 6204 2244']
train_368
what is year date and time mentioned?
['2002 08/08 21:49']
train_369
what is the name of the division ?
['TAKEDA DEVELOP DIVISION', 'Takeda Develop division']
train_370
to whom they can ask directly to disclose the details of "promotion study"?
['FDA']
train_371
what is the date mentioned in the letter
['8 January 2003', '8 january 2003']
train_372
To whom this letter is addressed?
['MPDRAP I Leader']
train_373
what is mentioned in the CC?
['CEOs and General Managers of Pharmaceutical Units', 'CEOs and general managers of pharmaceutical units']
train_374
combination therapy in the us market accounts for how much % of total actos sales .
['64', '64%']
train_375
What is the due date to evaluate data from actos 507?
['August 5']
train_376
who is the lead responsibility for developing additional monitoring plan for actos 508
['Amy Hagaman', 'Amy hagaman']
train_377
what is the due date for "draft justification for actos 508" ?
['August 12', 'august 12']
train_378
when was this last updated ?
['August 1, 2002', 'august 1, 2002']
train_379
Which is the core organization of Takeda pharmaceutical Company?
['Pharmaceutical development Division', 'Pharmaceutical Development Division']
train_380
Who made the opening remarks ?
['Dr. Kitazawa']
train_381
When is the clinical expert meeting scheduled?
['for October 1 and 2.', 'October 1 and 2']
train_382
what is the date mentioned in the given information ?
['20 April 2006', '20 april 2006']
train_383
What is the meeting time mentioned here?
['4:00pm - 5:00pm']
train_384
what is the place mentioned ?
['Meeting Room 403', 'meeting room 403']
train_385
Why was it suggested to prepare non-clinical "White paper"?
['to address the bladder issue', 'to address the bladder issue.']
train_386
who will forward the article regarding rosiglitazone and non clinical bladder data to andy ?
['Mondira']
train_387
What date is the meeting scheduled to develop the overall structure of the document?
['in early May']
train_388
Who presented an outline of the Cohen hypothesis?
['Philip Collett']
train_389
What is significant in the development of calculi?
['Raising the pH of male rat urine above 6.5']
train_390
What is the correlation observed in cohen's paper?
['0.61']
train_391
Why didn't rats eliminate calculi as humans do?
['Because rats are quadropeds', 'Because rats are quadropeds.']
train_392
What is the fullform of MAA?
['Marketing Authorization Application']
train_393
Which forum is mentioned in this document?
['Takeda Global Risk Management Forum', 'Takeda Global Risk Management Forum/March 22, 2004']
train_394
What is the issued date of this document?
['august 13, 2002', 'August 13, 2002']
train_395
Who is the Director of Nonclinical Safety and Efficacy?
['David baron', 'David Baron']
train_396
What is the duration of daily dosing?
['32-weeks', '32-weeks after BBN.']
train_397
Who updated the CEO on August 6?
['Mr. Saito']
train_398
By when should TPNA send outline of response to TCI ?
['August 19', 'by August 19']
train_399
When will Mr. Saito present outline to CEO?
['August 20', 'on August 20']