OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11635519	Sequences of PepA, PepA2, and PepA3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequences", "of", "PepA", ",", "PepA2", ",", "and", "PepA3", ".", "(" ] } ]
PMC11720107	In our study, the fluorogenic dye H2DCFDA was used to detect intracellular ROS, following a previously described protocol .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "study", "...
PMC10362265	The red color indicates the starting conformation and the blue shows the conformation after 300 ns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "red", "color", "indicates", "the", "starting", ...
PMC11629192	The patient showed poor response to two courses of IVIG and intravenous methylprednisolone (IVMP) treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patient", "showed", "poor", "response", ...
PMC3675084	BPR0L075 was previously reported to induce apoptosis by activation of caspase-3 in human cervical carcinoma KB cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "BPR0L075", "was", "previously", "reported", ...
PMC11462929	In pediatric BCP‐ALL clinical samples from St. Jude cloud database, BENC‐CNA was observed only in two out of 1664 (0.12%) samples (Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	Above, we have shown that genes that have different wiring patterns in cancer and control iCells tend to be cancer related.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Above", ",",...
PMC11727638	In major hematologic tumor models, this analysis is difficult because the weak connections between cells are often disrupted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "major", "hematologic", "tum...
PMC11672881	Our results indicate that the combination treatment significantly inhibited cell viability and induced apoptosis more effectively than either agent alone, with optimal synergy observed at concentrations of 25 µM CU and 10 µM TQ against A375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584319	The medium was replaced with fresh medium containing 0.5 mg/mL 3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide (MTT) (Biosesang, Seongnam, Korea) reagent, and the plates were incubated for 30 min (HepG2 cells) or 2 h (MEFs) at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The decreased maturation of th3 Mk, with loss of the mature polyploid profile, correlated with a reduced in vivo Plt biogenesis and impaired in vitro differentiation of th3 Mk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	Taking VHL as a target, transfecting it into renal cancer cells with appropriate methods, increasing the expression of the VHL gene, and correcting the apoptosis defects of tumor cells are very important treatment strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678368	These theoretical results are in very good agreement with the crystallographic data for trans-[PtCl2(7AI3CA)2] .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "theoretical", "results", "are", "in", "very", "goo...
PMC9429973	This data could suggest that mutant cell lines have more efficient protein folding mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "data", "could", "suggest", "that", "mutant", "cell", "li...
PMC8170755	Mouse anti-human NM23-H1 (Santa Cruz Biotechnology, Inc.) and mouse anti-human CD44v6 (Abcam, Cambridge, UK) antibodies were diluted (1:1000) in TBST buffer (20 mM Tris–HCl, 500 mM NaCl, 0.5% Tween 20, pH 7.4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	B Quantification of β-Gal positive cells presented in “A”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Quantification", "of", "β-Gal", "positive", "cells", "presented", "in", "“", "A"...
PMC10114490	To get a deeper insight into the phenotypic differences between PD and PD iHDF-T, we performed expression profiling by RNA sequencing (RNAseq).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10530622	Oxalate-enhanced release of proinflammatory cytokines from M1 macrophages is known for its pivotal role in dyslipidemia and vascular inflammation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oxalate-enhanced", "release", "of", ...
PMC9856122	Molecular docking of 38 Chinese patent drugs including phytocompounds, flavonoids and alkaloids, was studied for a molecular docking study against RdRp, ACE2, and M. The in silico study, with the help of AutoDock Vina, the findings demonstrated that morphine, codeine, indirubin, and BBR showed effective binding capacity (>−6.0 kcal/mol) against M; however, their binding affinity against RdRp was much higher (>−8.1 kcal/mol) than that of M .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	Conversely, cell death was found to be reduced in Rip3 Casp8 BMDMs and especially in Rip3 Casp8 Casp1/11 BMDMs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "cell", ...
PMC11726183	We have utilized LigPrep, Schrodinger, LLC, NY, 2023 and ‘Protein Preparation Workflow’ Schrodinger, LLC, NY, 2023 for preparing ligand and protein for assigning 3D coordinates and protonation state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	Emetine has also been found in in-ovo studies to dramatically delay NDV-induced death in chicken embryos by reducing the NDV virus titers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emetine", "h...
PMC9436459	Albasin A (3) possessing a prenyl moiety at C-7″ was discovered from the root bark of M. alba .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Albasin", "A", "(", "3...
PMC9429973	The two cohorts compared had similar demographics, reason for admission and indication for DOAC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "two", "cohorts", "compared", "had", "similar", "demo...
PMC7039683	Count’ in the color key indicates the sum for different number of each motif ‘frequency’. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Count", "’", "in", "the", "...
PMC10568263	This study used gold nanoparticles (Au NPs) coated on the surface of MnO2 to prevent oxidation issues, hoping to enhance the sensor stability and selectivity simultaneously.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9611901	These results could be due to the complex composition of the vegetable and synthetic tanning agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "could", "be", "due", "to", "...
PMC9429973	Summary/Conclusion: Vamifeport prevented formation of BT-mediated NTBI in the plasma of Hbb mice, suggesting iron restriction by ferroportin inhibition prevents formation of potentially harmful reactive plasma iron species.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: We find that SLC7A1/CAT1-mediated arginine uptake and its catabolism to spermidine control erythroid commitment and differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "find", "that", ...
PMC2614416	Prior to use, the lysates are aliquotted into 100 μg total protein portions and stored at -80°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to", "use", "...
PMC10154881	Experimental schema for depletion assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "schema", "for", "depletion", "assay", "." ] } ]
PMC10607604	We carried out a preliminary analysis (PTPN13 expression, growth rate, and migratory capacity) in four representative HGSOC cell lines available at the “SIRIC-Montpellier cancer” cell bank: COV-318, KURAMOCHI, OVCAR-3, and OVCAR-8 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Our retrospective series confirmed good survival for NRR patients, but 36% patients were R/R after first line, with refractory patients showing a dismal outcome despite intensive treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614416	Peptide Nanotrap (TR5/25109/42): 150 μm × 50 mm; 400 nL volume. •	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peptide", "Nanotrap", "(", "TR5/25109/42", "):", "150", "μm...
PMC11680578	Based on these findings, concentrations of 1 nM for PTX and 0.5 µM for RGZ were selected for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "th...
PMC9693627	The focus of our research is PTCD2, a mysterious protein whose function was unknown despite the available data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "focus", "of", "our", ...
PMC11476222	We utilized a rapid and robust sample preparation method and developed a technique capable of separating ganglioside isomers using a ZIC-HILIC column in a 25 min runtime.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	But we still cannot eliminate the involvement of GPX4 in the function of TRIB2 to affect ferroptosis triggered by other agonists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "we", ...
PMC10551595	Docking studies displayed reasonable binding energies between GinA and the target proteins Bcl‐2, Bcl‐xL, XIAP‐BIR3 and cIAP1‐BIR3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Docking", "studies", "displayed", ...
PMC11122631	In 2020, the overall incidence rate of oral cancer was 21.8 per 100,000, which rates fourth among cancer-related deaths of male Taiwanese people.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11190062	Cell viability measurements were performed using CellTiter Glo 2.0 Cell Viability Assay from Promega (Madison, WI, USA) according to the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	Cells were separately stained with BD Phosflow Alexa Fluor 647 mouse anti-Stat3 (BD Biosciences, 557815) or Alexa Fluor 647 mouse anti-Stat5 (BD Biosciences, 612599).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11537649	A dual luciferase reporter assay was performed to verify the interaction of miR-152-3p and CDK6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "dual", "luciferase", "reporter", "assay", ...
PMC4277423	HIV-1 envelope HIV-1 envelopeYu-2 is derived from a R5 tropic clade B virus .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIV-1", "envelope", "HIV-1", "envelopeYu-2", "is", "derived", "from", "a", ...
PMC11283030	•This is the first report about the prognosis of ACLY and p-ACLY in ccRCC.•ACLY is correlated with immune infiltrates in ccRCC.•ACLY inhibition attenuates ccRCC progression possibly through EMT and mTORC1 pathways.•Combination of ACLY and immune checkpoints may be a novel anticancer strategy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11455164	Conclusion: Our preliminary in vitro data on the effects of thyroid hormones T3 and T4, and the thyroid hormone metabolite tetrac on MSC migration shows a distinct behaviour of MSCs in the presence of either T3 or T4 depending on the breast cancer cell subtype, suggesting a role of non-genomic, integrin αvβ3-mediated thyroid hormone action on MSC biology within the breast tumor microenvironment that warrants further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Within different subtypes of malignancy, we found that NK/T cell lymphoma had the worst survival outcome, followed by T cell and B cell lymphoma (median OS time 0.6, 2 and 19 months, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	Similar staining protocol was followed except that the anti-P-gp (4E3) and complementary secondary antibody (same as above) were diluted (1:500 and 1:300, respectively) in blocking solution without Tween-20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060	For IMAC-enriched samples, reversed phase chromatography was performed on eluted peptides using a Dionex UltiMate 3000 RSLC nano system (Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11468365	Equation (16) shows the .16[12pt] $$MAE= ^\|_^-_^\|}.$$=∑i=1nyai-ypin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equation", "(", "16", ")", "shows", "the", ".16[12pt", "]", "$", "$", ...
PMC9429973	Aims: In this study, we aim to report our experience in patients with TTP, identify the main clinical and laboratory disease findings, treatment patterns, and evolution in these patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11454387	However, H6PD has 11β-HSD1-independent functions, such as the recently described modulation of breast cancer cell properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "H6PD", "has", "11β-HSD...
PMC11591052	This is consistent with the previously obtained data on the 20E-mediated increase in protein synthesis in differentiated myotubes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "consistent", "with", "th...
PMC11707577	Spheroid integrity after PDT was assessed 24 h after the treatment with G) M13EGFR(TNP) or H) HSA‐TM bioconjugates, by acquiring confocal images of Hoechst (cyan) labeled spheroid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	Moreover, miR-375-3p is a widely and functionally active noncoding RNA molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "miR-375", "-", "3p", "is", "a", "widely", ...
PMC9388315	Gwang et al. demonstrated water extract of Cinnamon can induce apoptosis in a colorectal cancer cell by ROS-dependent NF-κB and ATF3 activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gwang", "et"...
PMC11718274	The induction of apoptosis in both control and Y2O3NPs -treated A-431 cells was assessed using a chromatin diffusion assay based on the principle that apoptotic cells exhibit numerous alkali-labile sites, which, when exposed to alkaline conditions, yield small fragments of DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	Notably, LOC1886 decreased protein levels of both endogenous and exogenous GPX4-WT, but not the GPX4-C66S mutant (Supplementary Fig. 8c), and inhibited the 2-BP enhancement of RSL3-induced ferroptosis sensitivity (Supplementary Fig. 8d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	PCR was performed, exactly as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCR", "was", "performed", ",", "exactly", "as", "previously", "described", "." ] } ]
PMC11257988	Vreka et al. found that IKKα is a partner of KRAS non-oncogene addiction, and specifically synergizes with mutant KRAS to induce tumorigenesis, providing survival advantages for mutant cells in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763111	Statistical significance was determined by two-tailed unpaired Student's t-test. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "determined", "by", "two-tailed", "unpaired", "Student", ...
PMC7192625	The user can then search for a specific region of interest by entering genomic coordinates, the gene name, or simply by right-clicking on one of the nodes in the left panel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	One approach involves the engineering of these cells to limit their expression of HLA molecules, thereby reducing their immunogenicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "approach", "involves"...
PMC9100622	The slowdown of S-phase progression by Atorvastatin was also rescued by MEV (Figure 4H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "slowdown", "of", "S-phase", "progression", "by"...
PMC8427838	After injection of the sample onto the trapping column, the column was washed at a rate of 2 μl/min with 2% acetonitrile and 0.1% formic acid in water for 4 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	Briefly, CCRF-CEM T-ALL were resuspended at 2 × 10 cells per ml in RPMI1640 and pre-incubated ± muCCL198-83 for 5 min, ligand-adjusted to 200 nM of CCL19 or CCL21, and allowed to internalize CCR7 for the indicated times.	[ { "tags": [ "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11092382	Sophocarpine was found to attenuate ox-LDL-induced endothelial cell dysfunction and apoptosis through suppression of the NF-κB pathway in human aortic endothelial cells (Fang et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9813422	In addition, most research has been conducted with virus-infected cell lines, not clinical samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "most", "research", "has", ...
PMC11746942	Cells were treated with 25 μg/mL IL-6 (Sino Biological, 10395-HNAE) or 25 μg/mL IL-22 (Sino Biological, 13059-HNAE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells",...
PMC8873393	UV exposure altered gene expression in the cytoplasm fraction within hours (Fig. 3A, B), and most induced genes in the early phase of DNA repair process were involved in DNA damage response (clusters 2 and 3 in Fig. 3C, Table S3), genes activated in the late response time, by contrast, encoded proteins that are enriched in the translational regulation process (clusters 4 and 5 in Fig. 3C, Table S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11488203	This increased anti-tumor efficiency is associated with the presence of distinct factors in taxol-loaded EVs/exosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "increased", "anti-tumor", "efficiency", "is", "associated...
PMC7887261	OncoArray genotyping data for 17,878 LCs vs. 13,425 controls; (6) Affymetrix exome array data for 5364 LCs vs. 5724 controls; (7) UK Biobank (UKB) genotyping data for 2166 LCs vs. 401,453 controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	SGD-UBD253 is a chemical probe that potently and selectively inhibits the HDAC6-Ub binding domain (UBD; ref.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SGD-UBD253", "is", "a", "chemical", "p...
PMC11409031	Changes in cell line viability of HEY cells after inhibition of PFN1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Changes", "in", "cell", "line", "viability", "of", "HEY", "cells",...
PMC11634027	Adult wing phenotypes of Ds-ICD motif deletions. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adult", "wing", "phenotypes", "of", "Ds-ICD", "motif", "deletions", ".", "(" ] } ]
PMC10040136	A recent study demonstrated that TGF-β1 promotes the transformation of resident fibroblasts into CAFs in GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "recent", "study", "demonstrated", "that", "TGF-β1...
PMC11530949	Nitric Oxide (NO) Level The Natrix kit was used to measure NO level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nitric", "Oxide", "(", "NO", ")", "Level", "The", "Na...
PMC11790599	Untreated and TSL-treated cells were incubated with 1 mg/mL of FITC-dextran (70 kDa) (Invitrogen) in the appropriate serum-free medium in a 37°C, 5% CO2 incubator for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604768	Following isolation, the RNA fraction was treated with TURBO DNase (Invitrogen) to remove any plasmid DNA carryover.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "isolation", ","...
PMC9429973	However, despite positive outcomes with currently approved CAR-T cell tx, many patients fail to respond or relapse after initial response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC9429973	Sixty-day and 6-month mortality were 33% and 65%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sixty-day", "and", "6-month", "mortality", "were", "33", "%", "and", "65", ...
PMC11805741	Other rare, longer carotenoids (C50), like bacterioruberin, are derived by the addition of two isoprene units (C5) to the C40 chain (Yang et al. 2015).They are synthesized in specific types of bacteria as an adaptation strategy under different stress condition (Hegazy et al. 2020; Noby et al. 2023).The long conjugated double bond system of the polyene chain constitutes the carotenoid chromophore, which is responsible for the coloration or pigmentation of carotenoids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mean (SD) Hb occupancy of GBT021601, determined via PK analysis, was 25.8% (3.9%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "(", "SD",...
PMC11190062	The comparative Ct-method was used to estimate relative changes in gene expression, and ACTB (for CD138 primary cells) or TBP (for RPMI-8226) were used as housekeeping genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLin...
PMC11806818	Yang et al. combined two-dimensional Au@PdMo nanozymes with electrochemical reduction desorption to construct a new cell sensor for ultrasensitive detection and non-destructive release of MCF-7 CTCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC10723784	The results showed that cannabinoids exert irreversible cytotoxicity in the carcinoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "cannabinoids", "exert", "irreversible", "cytotoxic...
PMC11666785	In this respect, single molecule localization microscopy (SMLM) and related microscopy techniques have proven to be valuable tools for unraveling the nanoscopic world of biomolecular complexes.. Since the classical work of Moerner in the year 1989 and inception of super-resolution microscopy in the subsequent years with the advent of STED, SI and SMLM techniques (PALM, fPALM and STORM), super-resolution imaging has taken a giant step towards unveiling many biological processes occurring at single molecule level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	Severe tumor regression and impaired angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Severe", "tumor", "regression", "and", "impaired", "angiogenesis", "." ] } ]
PMC10547921	Therefore, other types of payloads such as RNA inhibitors, immuno-agonists, and apoptosis-promoting Bcl-xL inhibitors are being developed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "other", ...
PMC10706275	The outcomes were observed by FlowJo V10 software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "outcomes", "were", "observed", "by", "FlowJo", "V10", "software", "." ] } ]
PMC11401358	SF was heated to 95 °C, which was named SF-95 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SF", "was", "heated", "to", "95", "°", "C", ",", "which", ...
PMC9786247	However, the events leading to or preventing transmission of C. burnetii from cattle to humans have not been adequately investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC11777207	Restriction digestions were performed, and agarose gels were run for verification of the correct digestions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Restriction", "digestions", "were", "performed", ",", ...
PMC11705067	The results from the HPA database showed that protein expression levels of CDGs had also been consistent with mRNA expression in ccRCC (Fig. 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9817179	The values are averaged from 24 (D), 23 (E), or 10 (F) cells measured in 2 (D), 2 (E), or 3 (F) independent transfection and imaging sessions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	An unplanned subgroup analysis by age (60 vs > 60 yrs) showed a significant different EFS at one year for younger patients with R-MBVP, not found in patients > 60 yrs (Bromberg et al, 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7192625	Two replicates of ChipSeq for H3K27me3 and H3K36me3 were downloaded from (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "replicates", "of", "ChipSeq", "for", "H3K27me3", "and", "...
PMC9429973	In third line, there was no difference between imatinib, nilotinib, dasatinib or bosutinib although numbers of patients were small.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "third"...
PMC11441402	We recommend that standard operating procedures are established to ensure consistent quantification between different research laboratories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "recommend", "that", "standard", "operating", "pr...
PMC3035438	In striking contrast, the ch-IgHM transcripts were drastically reduced in CstF-64 cells (over 27-fold reduction).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "striking", "contrast", ",", ...

PMC11635519

Sequences of PepA, PepA2, and PepA3. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequences", "of", "PepA", ",", "PepA2", ",", "and", "PepA3", ".", "(" ] } ]

PMC11720107

In our study, the fluorogenic dye H2DCFDA was used to detect intracellular ROS, following a previously described protocol .

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PMC10362265

The red color indicates the starting conformation and the blue shows the conformation after 300 ns.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "red", "color", "indicates", "the", "starting", ...

PMC11629192

The patient showed poor response to two courses of IVIG and intravenous methylprednisolone (IVMP) treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patient", "showed", "poor", "response", ...

PMC3675084

BPR0L075 was previously reported to induce apoptosis by activation of caspase-3 in human cervical carcinoma KB cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "BPR0L075", "was", "previously", "reported", ...

PMC11462929

In pediatric BCP‐ALL clinical samples from St. Jude cloud database, BENC‐CNA was observed only in two out of 1664 (0.12%) samples (Figure S2).

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PMC6379402

Above, we have shown that genes that have different wiring patterns in cancer and control iCells tend to be cancer related.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Above", ",",...

PMC11727638

In major hematologic tumor models, this analysis is difficult because the weak connections between cells are often disrupted.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "major", "hematologic", "tum...

PMC11672881

Our results indicate that the combination treatment significantly inhibited cell viability and induced apoptosis more effectively than either agent alone, with optimal synergy observed at concentrations of 25 µM CU and 10 µM TQ against A375 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8584319

The medium was replaced with fresh medium containing 0.5 mg/mL 3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide (MTT) (Biosesang, Seongnam, Korea) reagent, and the plates were incubated for 30 min (HepG2 cells) or 2 h (MEFs) at 37 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The decreased maturation of th3 Mk, with loss of the mature polyploid profile, correlated with a reduced in vivo Plt biogenesis and impaired in vitro differentiation of th3 Mk.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8759873

Taking VHL as a target, transfecting it into renal cancer cells with appropriate methods, increasing the expression of the VHL gene, and correcting the apoptosis defects of tumor cells are very important treatment strategies.

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PMC11678368

These theoretical results are in very good agreement with the crystallographic data for trans-[PtCl2(7AI3CA)2] .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "theoretical", "results", "are", "in", "very", "goo...

PMC9429973

This data could suggest that mutant cell lines have more efficient protein folding mechanisms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "data", "could", "suggest", "that", "mutant", "cell", "li...

PMC8170755

Mouse anti-human NM23-H1 (Santa Cruz Biotechnology, Inc.) and mouse anti-human CD44v6 (Abcam, Cambridge, UK) antibodies were diluted (1:1000) in TBST buffer (20 mM Tris–HCl, 500 mM NaCl, 0.5% Tween 20, pH 7.4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11453018

B Quantification of β-Gal positive cells presented in “A”.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Quantification", "of", "β-Gal", "positive", "cells", "presented", "in", "“", "A"...

PMC10114490

To get a deeper insight into the phenotypic differences between PD and PD iHDF-T, we performed expression profiling by RNA sequencing (RNAseq).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10530622

Oxalate-enhanced release of proinflammatory cytokines from M1 macrophages is known for its pivotal role in dyslipidemia and vascular inflammation .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oxalate-enhanced", "release", "of", ...

PMC9856122

Molecular docking of 38 Chinese patent drugs including phytocompounds, flavonoids and alkaloids, was studied for a molecular docking study against RdRp, ACE2, and M. The in silico study, with the help of AutoDock Vina, the findings demonstrated that morphine, codeine, indirubin, and BBR showed effective binding capacity (>−6.0 kcal/mol) against M; however, their binding affinity against RdRp was much higher (>−8.1 kcal/mol) than that of M .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11545737

Conversely, cell death was found to be reduced in Rip3 Casp8 BMDMs and especially in Rip3 Casp8 Casp1/11 BMDMs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "cell", ...

PMC11726183

We have utilized LigPrep, Schrodinger, LLC, NY, 2023 and ‘Protein Preparation Workflow’ Schrodinger, LLC, NY, 2023 for preparing ligand and protein for assigning 3D coordinates and protonation state.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9812014

Emetine has also been found in in-ovo studies to dramatically delay NDV-induced death in chicken embryos by reducing the NDV virus titers .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emetine", "h...

PMC9436459

Albasin A (3) possessing a prenyl moiety at C-7″ was discovered from the root bark of M. alba .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Albasin", "A", "(", "3...

PMC9429973

The two cohorts compared had similar demographics, reason for admission and indication for DOAC.

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PMC7039683

Count’ in the color key indicates the sum for different number of each motif ‘frequency’. (

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PMC10568263

This study used gold nanoparticles (Au NPs) coated on the surface of MnO2 to prevent oxidation issues, hoping to enhance the sensor stability and selectivity simultaneously.

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PMC9611901

These results could be due to the complex composition of the vegetable and synthetic tanning agents.

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PMC9429973

Summary/Conclusion: Vamifeport prevented formation of BT-mediated NTBI in the plasma of Hbb mice, suggesting iron restriction by ferroportin inhibition prevents formation of potentially harmful reactive plasma iron species.

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PMC9429973

Results: We find that SLC7A1/CAT1-mediated arginine uptake and its catabolism to spermidine control erythroid commitment and differentiation.

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PMC2614416

Prior to use, the lysates are aliquotted into 100 μg total protein portions and stored at -80°C.

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PMC10154881

Experimental schema for depletion assay.

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PMC10607604

We carried out a preliminary analysis (PTPN13 expression, growth rate, and migratory capacity) in four representative HGSOC cell lines available at the “SIRIC-Montpellier cancer” cell bank: COV-318, KURAMOCHI, OVCAR-3, and OVCAR-8 cells.

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PMC9429973

Image: Summary/Conclusion: Our retrospective series confirmed good survival for NRR patients, but 36% patients were R/R after first line, with refractory patients showing a dismal outcome despite intensive treatments.

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PMC2614416

Peptide Nanotrap (TR5/25109/42): 150 μm × 50 mm; 400 nL volume. •

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PMC11680578

Based on these findings, concentrations of 1 nM for PTX and 0.5 µM for RGZ were selected for further analysis.

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PMC9693627

The focus of our research is PTCD2, a mysterious protein whose function was unknown despite the available data.

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PMC11476222

We utilized a rapid and robust sample preparation method and developed a technique capable of separating ganglioside isomers using a ZIC-HILIC column in a 25 min runtime.

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PMC8316344

But we still cannot eliminate the involvement of GPX4 in the function of TRIB2 to affect ferroptosis triggered by other agonists.

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PMC10551595

Docking studies displayed reasonable binding energies between GinA and the target proteins Bcl‐2, Bcl‐xL, XIAP‐BIR3 and cIAP1‐BIR3.

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PMC11122631

In 2020, the overall incidence rate of oral cancer was 21.8 per 100,000, which rates fourth among cancer-related deaths of male Taiwanese people.

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PMC11190062

Cell viability measurements were performed using CellTiter Glo 2.0 Cell Viability Assay from Promega (Madison, WI, USA) according to the manufacturer’s protocol.

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PMC10940855

Cells were separately stained with BD Phosflow Alexa Fluor 647 mouse anti-Stat3 (BD Biosciences, 557815) or Alexa Fluor 647 mouse anti-Stat5 (BD Biosciences, 612599).

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PMC11537649

A dual luciferase reporter assay was performed to verify the interaction of miR-152-3p and CDK6.

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PMC4277423

HIV-1 envelope HIV-1 envelopeYu-2 is derived from a R5 tropic clade B virus .

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PMC11283030

•This is the first report about the prognosis of ACLY and p-ACLY in ccRCC.•ACLY is correlated with immune infiltrates in ccRCC.•ACLY inhibition attenuates ccRCC progression possibly through EMT and mTORC1 pathways.•Combination of ACLY and immune checkpoints may be a novel anticancer strategy.

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PMC11455164

Conclusion: Our preliminary in vitro data on the effects of thyroid hormones T3 and T4, and the thyroid hormone metabolite tetrac on MSC migration shows a distinct behaviour of MSCs in the presence of either T3 or T4 depending on the breast cancer cell subtype, suggesting a role of non-genomic, integrin αvβ3-mediated thyroid hormone action on MSC biology within the breast tumor microenvironment that warrants further investigation.

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PMC9429973

Within different subtypes of malignancy, we found that NK/T cell lymphoma had the worst survival outcome, followed by T cell and B cell lymphoma (median OS time 0.6, 2 and 19 months, respectively).

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PMC6160470

Similar staining protocol was followed except that the anti-P-gp (4E3) and complementary secondary antibody (same as above) were diluted (1:500 and 1:300, respectively) in blocking solution without Tween-20.

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PMC5673060

For IMAC-enriched samples, reversed phase chromatography was performed on eluted peptides using a Dionex UltiMate 3000 RSLC nano system (Thermo Fisher Scientific).

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PMC11468365

Equation (16) shows the .16[12pt] $$MAE= ^|_^-_^|}.$$=∑i=1nyai-ypin.

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PMC9429973

Aims: In this study, we aim to report our experience in patients with TTP, identify the main clinical and laboratory disease findings, treatment patterns, and evolution in these patients.

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PMC11454387

However, H6PD has 11β-HSD1-independent functions, such as the recently described modulation of breast cancer cell properties.

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PMC11591052

This is consistent with the previously obtained data on the 20E-mediated increase in protein synthesis in differentiated myotubes .

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PMC11707577

Spheroid integrity after PDT was assessed 24 h after the treatment with G) M13EGFR(TNP) or H) HSA‐TM bioconjugates, by acquiring confocal images of Hoechst (cyan) labeled spheroid.

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PMC11781181

Moreover, miR-375-3p is a widely and functionally active noncoding RNA molecule.

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PMC9388315

Gwang et al. demonstrated water extract of Cinnamon can induce apoptosis in a colorectal cancer cell by ROS-dependent NF-κB and ATF3 activation .

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PMC11718274

The induction of apoptosis in both control and Y2O3NPs -treated A-431 cells was assessed using a chromatin diffusion assay based on the principle that apoptotic cells exhibit numerous alkali-labile sites, which, when exposed to alkaline conditions, yield small fragments of DNA.

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PMC11746948

Notably, LOC1886 decreased protein levels of both endogenous and exogenous GPX4-WT, but not the GPX4-C66S mutant (Supplementary Fig. 8c), and inhibited the 2-BP enhancement of RSL3-induced ferroptosis sensitivity (Supplementary Fig. 8d).

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PMC11566417

PCR was performed, exactly as previously described .

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PMC11257988

Vreka et al. found that IKKα is a partner of KRAS non-oncogene addiction, and specifically synergizes with mutant KRAS to induce tumorigenesis, providing survival advantages for mutant cells in vitro and in vivo.

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PMC11763111

Statistical significance was determined by two-tailed unpaired Student's t-test. *

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PMC7192625

The user can then search for a specific region of interest by entering genomic coordinates, the gene name, or simply by right-clicking on one of the nodes in the left panel.

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PMC11774747

One approach involves the engineering of these cells to limit their expression of HLA molecules, thereby reducing their immunogenicity.

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PMC9100622

The slowdown of S-phase progression by Atorvastatin was also rescued by MEV (Figure 4H).

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PMC8427838

After injection of the sample onto the trapping column, the column was washed at a rate of 2 μl/min with 2% acetonitrile and 0.1% formic acid in water for 4 min.

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PMC11395280

Briefly, CCRF-CEM T-ALL were resuspended at 2 × 10 cells per ml in RPMI1640 and pre-incubated ± muCCL198-83 for 5 min, ligand-adjusted to 200 nM of CCL19 or CCL21, and allowed to internalize CCR7 for the indicated times.

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PMC11092382

Sophocarpine was found to attenuate ox-LDL-induced endothelial cell dysfunction and apoptosis through suppression of the NF-κB pathway in human aortic endothelial cells (Fang et al., 2020).

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PMC9813422

In addition, most research has been conducted with virus-infected cell lines, not clinical samples.

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PMC11746942

Cells were treated with 25 μg/mL IL-6 (Sino Biological, 10395-HNAE) or 25 μg/mL IL-22 (Sino Biological, 13059-HNAE).

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PMC8873393

UV exposure altered gene expression in the cytoplasm fraction within hours (Fig. 3A, B), and most induced genes in the early phase of DNA repair process were involved in DNA damage response (clusters 2 and 3 in Fig. 3C, Table S3), genes activated in the late response time, by contrast, encoded proteins that are enriched in the translational regulation process (clusters 4 and 5 in Fig. 3C, Table S3).

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PMC11488203

This increased anti-tumor efficiency is associated with the presence of distinct factors in taxol-loaded EVs/exosomes.

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PMC7887261

OncoArray genotyping data for 17,878 LCs vs. 13,425 controls; (6) Affymetrix exome array data for 5364 LCs vs. 5724 controls; (7) UK Biobank (UKB) genotyping data for 2166 LCs vs. 401,453 controls.

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PMC11188874

SGD-UBD253 is a chemical probe that potently and selectively inhibits the HDAC6-Ub binding domain (UBD; ref.

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PMC11409031

Changes in cell line viability of HEY cells after inhibition of PFN1. (

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PMC11634027

Adult wing phenotypes of Ds-ICD motif deletions. (

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PMC10040136

A recent study demonstrated that TGF-β1 promotes the transformation of resident fibroblasts into CAFs in GIST.

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PMC11530949

Nitric Oxide (NO) Level The Natrix kit was used to measure NO level.

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PMC11790599

Untreated and TSL-treated cells were incubated with 1 mg/mL of FITC-dextran (70 kDa) (Invitrogen) in the appropriate serum-free medium in a 37°C, 5% CO2 incubator for 30 min.

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PMC11604768

Following isolation, the RNA fraction was treated with TURBO DNase (Invitrogen) to remove any plasmid DNA carryover.

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PMC9429973

However, despite positive outcomes with currently approved CAR-T cell tx, many patients fail to respond or relapse after initial response.

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PMC9429973

Sixty-day and 6-month mortality were 33% and 65%, respectively.

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PMC11805741

Other rare, longer carotenoids (C50), like bacterioruberin, are derived by the addition of two isoprene units (C5) to the C40 chain (Yang et al. 2015).They are synthesized in specific types of bacteria as an adaptation strategy under different stress condition (Hegazy et al. 2020; Noby et al. 2023).The long conjugated double bond system of the polyene chain constitutes the carotenoid chromophore, which is responsible for the coloration or pigmentation of carotenoids.

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PMC9429973

Mean (SD) Hb occupancy of GBT021601, determined via PK analysis, was 25.8% (3.9%).

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PMC11190062

The comparative Ct-method was used to estimate relative changes in gene expression, and ACTB (for CD138 primary cells) or TBP (for RPMI-8226) were used as housekeeping genes.

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PMC11806818

Yang et al. combined two-dimensional Au@PdMo nanozymes with electrochemical reduction desorption to construct a new cell sensor for ultrasensitive detection and non-destructive release of MCF-7 CTCs.

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PMC10723784

The results showed that cannabinoids exert irreversible cytotoxicity in the carcinoma cells.

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PMC11666785

In this respect, single molecule localization microscopy (SMLM) and related microscopy techniques have proven to be valuable tools for unraveling the nanoscopic world of biomolecular complexes.. Since the classical work of Moerner in the year 1989 and inception of super-resolution microscopy in the subsequent years with the advent of STED, SI and SMLM techniques (PALM, fPALM and STORM), super-resolution imaging has taken a giant step towards unveiling many biological processes occurring at single molecule level.

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PMC10976516

Severe tumor regression and impaired angiogenesis.

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PMC10547921

Therefore, other types of payloads such as RNA inhibitors, immuno-agonists, and apoptosis-promoting Bcl-xL inhibitors are being developed.

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PMC10706275

The outcomes were observed by FlowJo V10 software.

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PMC11401358

SF was heated to 95 °C, which was named SF-95 °C.

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PMC9786247

However, the events leading to or preventing transmission of C. burnetii from cattle to humans have not been adequately investigated.

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PMC11777207

Restriction digestions were performed, and agarose gels were run for verification of the correct digestions.

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PMC11705067

The results from the HPA database showed that protein expression levels of CDGs had also been consistent with mRNA expression in ccRCC (Fig. 2C).

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PMC9817179

The values are averaged from 24 (D), 23 (E), or 10 (F) cells measured in 2 (D), 2 (E), or 3 (F) independent transfection and imaging sessions.

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PMC9429973

An unplanned subgroup analysis by age (60 vs > 60 yrs) showed a significant different EFS at one year for younger patients with R-MBVP, not found in patients > 60 yrs (Bromberg et al, 2019).

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PMC7192625

Two replicates of ChipSeq for H3K27me3 and H3K36me3 were downloaded from (34).

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PMC9429973

In third line, there was no difference between imatinib, nilotinib, dasatinib or bosutinib although numbers of patients were small.

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PMC11441402

We recommend that standard operating procedures are established to ensure consistent quantification between different research laboratories.

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PMC3035438

In striking contrast, the ch-IgHM transcripts were drastically reduced in CstF-64 cells (over 27-fold reduction).

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