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OTAR3088
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BioData-CellLine_annotated

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PMC11621493
One milliliter EpiLife growth medium was added to the petri-dish and epidermis was vigorously rubbed back and forth to release single cells.
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PMC9429973
Patients whose main employment was housekeeping exhibited significantly lower mean values in both PCS and MCS (29.93 and 27.19 respectively) compared to patients in retirement (45.59 in PCS and 43.56 in MCS, respectively) (p<0.01) or public workers (48.59 in PCS and 54.04 in MCS, respectively).
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PMC11320834
In ECO 3 cells, the noted shift was from 0.16 mM for olaparib to 0.08 mM for OLL (Fig. 2DII), and in the ECO 4 tissue sample from 0.85 mM to 0.34 mM in the same configuration (Fig. 2EII).
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PMC10899471
Subsequent bioinformatic prediction and experimental validations showed that BATF2 expression was reduced by microRNA (miR)-939-3p mimic and increased by miR-939-3p inhibitor.
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PMC9727330
In addition, the amino acids in the synthetase site are, for the most part, conserved in human and bacterial ASNS.
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PMC11474209
Proinflammatory cytokines and chemokines like TNF-α, MCP-1, IL-6, and CXCL10, PI3K/AKT/NF-κβ phosphorylation were shown to be upregulated in Sertoli cells, Leydig cells, and germ cells resulting in male reproductive toxicity known as orchitis showing symptoms such as spermatogenesis impairment and testicular inflammation.
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PMC11730311
A general observation was that greatest losses of potency occurred when the lipidation was positioned in the C-terminal region of hαCGRP8-37, being consistent with a previous study on palmitoylation at K35C, which resulted in a 70-fold reduction of potency.
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PMC9261184
Figure 5 shows the total GHG emissions across different engine loads per unit of engine output for the generator (left) and main (right) engines.
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PMC11515150
Unpaired student t-test was used to compare quantitative differences between two samples, and two-way ANOVA was applied for multiple comparisons.
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PMC6642070
All mice were handled and maintained in accordance with the Animal Care and Use Committee of Macau University of Science and Technology.
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PMC11285179
The tipped balance between pro-angiogenesis and anti-angiogenesis factors contributes to maintaining tumor vascular growth .
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PMC11638764
Similar phenomena have been reported with proteasome inhibitors, where impaired protein homeostasis and aggregation are common (Hirabayashi et al., 2001; Kobayashi et al., 2007) .
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PMC10777969
FCP23 induces oxidative stress, DNA damage, and necrosis, while FCP26 kills cancer cells via apoptosis.
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PMC11473750
Anti-Vinculin antibody was used as a loading control in 1:3000 dilution.
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PMC11267036
Our data showed that DHM dose-dependently weakened the viability and enhanced apoptosis of MM cells.
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PMC11361748
We extended these in vivo findings by showing that pretreatment of A431 keratinocytes with Gö6976 prior to TPA stimulation significantly reduced the ability of their CM to stimulate neutrophil chemotaxis (Fig 4E).
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PMC9504875
HAZV N protein binds to the C-terminal region (aa 361–630) of TRIM25 (Figure 3D).
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PMC10969097
The clinical trial NCT04519879, started in 2021, is a phase 2 study that aims to investigate the effectiveness of white mushroom (Agaricus bisporus) supplements in reducing PSA levels in patients with recurrent or favourable-risk prostate cancer without previous treatment.
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PMC9429973
The overall response rates were 35% (20 of 57), 67% (36 of 54), 84% (42 of 50) and 95% (41 of 43) at 1, 3, 6 and 12 months, and CR rates were 17% (9 of 54), 24% (12 of 50) and 35% (15 of 43) at 3, 6 and 12 months.
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PMC9429973
Methods: - Results: RESULTS Of the 38 patients, 17 were women (45%) and 21 men (55%) with a median age at diagnosis of 38 years (range 11 - 82 years).
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PMC11758416
L cells should not become more than 80% confluent.
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PMC11754094
To investigate the underlying mechanism of CRISPR-driven large DNA deletion events, we performed a CRISPR interference (CRISPRi) screen targeting 794 genes referenced in Repair-seq plus genes identified as associated with DNA repair in the Human Protein Atlas website (Fig. 3a).
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PMC9429973
Summary/Conclusion: Defining specific molecular contributions in drug resistance is imperative for the correct use of targeted therapy.
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PMC11240448
For the DPD modules, elements of the global response matrix were calculated as below:(4) Rij=DPDs1−DPDs0DPDs0 Here the and are the DPD values for the same time point following EGF stimulation without and with drug perturbation, respectively.
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PMC11188874
Control experiments also showed that treatment of E.G7-Ova and B3Z cells with the HDAC6 inhibitors did not induce apoptosis (Supplementary Fig. S12C and S12D).
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PMC11775197
Moreover, in subsequent studies, other investigators have demonstrated that colonic epithelial PPARβ/δ overexpression positively affects mice’s susceptibility to colon cancer .
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PMC9429973
In weighted Cox analysis, OS was significantly improved in the avapritinib versus midostaurin cohort (hazard ratio [HR] [95% CI]: 0.59 [0.36, 0.97]; P<0.001).
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PMC5941560
SnpEff identified 9997 synonymous and 10,984 nonsynonymous mutations.
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PMC11699465
REAGENT or RESOURCESOURCEIDENTIFIERAntibodiesAnti-TMEM199Boster, ChinaCat # A14686-1Anti-FlagSigmaCat#F1804Anti-PD-L1R&DCat#1019Chemicals, peptides, and recombinant proteinsRIPA BufferThermoCat# 89901protease inhibitorSigmaCat#SRE0055Experimental models: Cell linesHEK293TATCC143BATCCCAOV3University of MacauOligonucleotidesTarget: mouse TMEM199#1, 5′-3': TTGCTTGCCGGCGAACGAC; 3′-5': GTCGTTCGCCGGCAAGCAA.Target: mouse TMEM199#2, 5′-3': TTCGCGCTTTGGGTCCTGG; 3′-5': CCAGGACCCAAAGCGCGAA.Target: mouse TMEM199#3, 5′-3': AGCCAATGAGGAGTATAAG; 3′-5': CTTATACTCCTCATTGGCT.Target: mouse TMEM199#4, 5′-3': GAGCTGGGCACGCAGCTTC; 3′-5': GAAGCTGCGTGCCCAGCTC.Target: human TMEM199#1, 5′-3': GTGCAGATCCCGGATGAGA; 3′-5': TCTCATCCGGGATCTGCAC.Target: human TMEM199#2, 5′-3': AAGCTCGGCCCGCAGCTTT; 3′-5': AAAGCTGCGGGCCGAGCTT.Target: human TMEM199#3, 5′-3': CCAGAACTAGTTGCCCGGC; 3′-5': GCCGGGCAACTAGTTCTGG.Target: human TMEM199#4, 5′-3': GGTGGGACTCTCAGCGACC; 3′-5': GGTCGCTGAGAGTCCCACC.Software and algorithmsR software HEK293 cells, 143B cells, and CAOV3 cells were all maintained in regular DMEM supplemented with 10% (v/v) FBS, penicillin–streptomycin.
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PMC9532503
The levels of other glycan forms, such as galactose, mannose, and fucose also exhibited differences, but were not significant in terms of functional activity.
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PMC11674146
These evidences have made us curious whether CLP36 was involved in the malignant behaviors of lymphoma cells, and this study hence commenced for the validation.
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PMC11590005
Data on participants’ monthly family income was also collected from the socioeconomic questionnaire administered during enrolment in Brazilian public universities.
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PMC11488203
Significance of the symbols indicate: * = p < 0.05; ** = p < 0.01; *** = p < 0.005; **** = p < 0.001.
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PMC11721064
E–F Heatmap and volcano plot of differentially expressed genes in skin and corneal samples from bulk sequencing.
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PMC10999934
A false discovery rate of less than 0.05 and a P value of less than 0.05 were considered the threshold for significance.
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PMC11767725
Recent research demonstrates that bacteriophages can specifically target Staphylococcus aureus—a bacterial species closely linked to AD flares—while preserving beneficial skin microbes such as S. epidermidis.
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PMC11621493
For targeted mass spectrometry analysis, COS7 cells were transfected with pcDNA4/HisMaxC-mPla2g4d or pcDNA3.1(+)/myc-HisB-hPLA2G4D as well as the empty vector (pcDNA4/HisMaxC) or pcDNA4/HisMaxC-mPla2g4d-S370A as control in 6-well plates.
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PMC8345486
Compound 23 (40 μM) was twice as toxic to spheroids as cisplatin (70 μM) (Figure 12C).
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PMC11792888
Bar graph summary representing the percentage of cells in G0/G1, S, and G2/M. Bars represent an average of six measurements. (
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PMC9621239
The different haplotypes of the X gene varied between tumour and adjacent non-tumour tissues in all 24 patients (Figure 1A), suggesting that the evolution of the HBV X gene was independent.
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PMC10891340
The scale bar is 100 μm. (
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PMC9841531
Mean ± SEM of at least three independent experiments is shown.
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PMC11786767
B: Line scanning analysis of biotin-DHPE distribution across the chromosome.
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PMC11467800
A variety of cancer models have been established using zebrafish larvae and adults in the literature. , , , ,
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PMC11401350
Three days upon transduction with the anti-CD4CAR CD8-LVs, the lymphoma cells were analysed by FACS for the presence of CD4 AITL cells and CD8 TILs.
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PMC11011837
Untargeted polar metabolomics chromatographic separation was conducted by following the indications reported by Jian Li et al. .
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PMC4360730
For example, rather than connect cell line GM12878 (EFO:0002784) directly to B cell (CL:0000236), we used a more general term B-cell-derived cell line (EFO:0001640) to extend the relationships to current and future B cell lines.
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PMC11429241
In this manuscript, it is referred to as a spherical scaffold.
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PMC11470999
One significant challenge in treating brain metastases is the blood‒brain barrier (BBB), which limits the effectiveness of many systemic therapies.
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PMC5574817
Fig. 2Fig.
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PMC10858941
The use of an organ-on-chip model (GBM on a chip) that simulates the tumour landscape in vivo has allowed us to observe how NNC acts in the different tumour zones and to show its preferential effect in hypoxic regions.
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PMC11635087
The chlorophyll autofluorescence was excited with a 559 nm diode laser.
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PMC9429973
Aims: Here, we sought to overcome the aforementioned limitation and obtain more insight into in vivo CSR in CLL using a highly-sensitive, next generation sequencing (NGS) methodology.
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PMC11530949
Moreover, the Ag-doped CuO NPs demonstrated a significant ability to induce apoptosis in liver cancer cells.
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PMC5261804
To compare protein and PPI essentiality, we ranked each interaction by its PPI essentiality, and then compared this to the maximum protein essentiality of the interaction source and target.
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PMC9429973
Of HTB patients, 7 were RS+, 6 were on iron chelators.
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PMC4369959
Chemical analysis of ginger shows that it contains over 400 different compounds.
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PMC11743316
The usage of glucose and other sources of carbon in cancer is substantially more diverse than previously thought.
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PMC11786767
In Ki-67 knockdown cells, we also observed a similar phenotype in that Ki-67-expressing cells exhibited uneven chromosome segregation (Fig. 8F and G, lower panels).
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PMC11525028
ATF4 is regulated by NAT10 through ac4C modification (A) Volcano plot showing the mRNA expression of NAT10-KO compared to control cells.
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PMC11767725
S. aureus exacerbates the epidermal barrier disruption by producing enterotoxins that activate IL-23 and IL-17 pathways, intensifying keratinocyte activation and neutrophilic infiltration.
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PMC9429973
According to the BMI values of the sarcopenic patients, 3 were underweight and 1 was obese.
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PMC10907726
Fig. 2B).
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PMC11585587
Multiple myeloma (MM) is a hematological malignancy characterized by the unrestricted proliferation of plasma cells that secrete immunoglobulin in the bone marrow.
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PMC9065483
Altogether, these data strongly support a key role of EGFR signaling in eliciting vanadate’s viral sensitizing effects.
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PMC11461833
These results suggest that STXBP5 or STXBP6 may be a risk factors for senescence.
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PMC11705547
Furthermore, cisplatin reduced the expression of Gr-1 on MDSCs and increased the expression of DC markers like CD40, CD80 and CD86, indicating that cisplatin can potentially induce the differentiation of immunosuppressive MDSCs to the immunostimulatory DCs .
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PMC11659734
Nine concentrations of BPP were tested in a preliminary concentration‐finding test (i.e. 1.25, 2.5, 5, 10, 20, 40, 60, 80, 100 μM).
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PMC11271278
Cancer genomes are composed of many complex structural alterations on chromosomes and extrachromosomal DNA (ecDNA), making it difficult to identify non-coding enhancer regions that are hijacked to activate oncogene expression.
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PMC11314247
No statistically significant differences were found in the G0–G1 and S stages between the cells treated with HO-AAVPA and the control (Figure 5).
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PMC9429973
Aims: This study was conducted to investigate the efficacy and safety of Zanubrutinib plus Rituximab in elderly unfit Patients With Previously Untreated Diffuse large-B cell Lymphoma in China.
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PMC7823217
Advance stages of pancreatic cancer have very poor prognosis with a five-year survival rate ∼2–5% cases .
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PMC11755519
Moreover, exosomes from malignant cells disrupted the monolayer to a much greater extent than exosomes from control cells.
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PMC8524093
Although viral RNA was present in several maternal tissues, fetal tissues and placenta demonstrated no histological changes or virus presence (Chen et al., 2010).
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PMC11754094
Genome-editing tools based on Cas9 or nCas9 exhibited frequencies of large-deletion events that varied by target site, and for the nCas9-based systems, by type of genetic modification.
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PMC6892818
Bars show mean fold change of 5–6 technical replicates ± SEM.
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PMC11502327
However, it can only reduce the toxic side effects of DOX, and cannot improve the tumor targeting and drug delivery ability of drug therapy.
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PMC11694346
These findings provide compelling evidence for the nucleophilic substitution reaction and the subsequent formation of the fluorescent BT-NH product, corroborating the proposed mechanism.
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PMC9275501
The mechanisms of MDR include elevated metabolism of xenobiotics, enhanced efflux of drugs, growth factors, increased DNA repair capacity, and genetic factors (gene mutations, amplifications, and epigenetic alterations) (Bukowski et al., 2020).
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PMC9424261
In conclusion, our data are the first to show that CA can increase the sensitivity of liver cancer cells to ferroptosis by upregulating HERPUD1.
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PMC11699042
k Raw viability of A-673, HeLa, and MCF-7 cell lines subjected to each compound (1 µM) included in the drug screening after 0, 6, and 12 months of continuous long-term culture (m0, m6, and m12).
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PMC11001582
Our inability to immunolocalize polyPR may be due to using antibodies raised against short peptides, which likely recognize short linear epitopes, rather than the native polyPR structure.
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PMC10965680
LD analysis revealed that the highest average LD (r2) was found in Guizhou goats, whereas the lowest LD was observed in Xiangdong black goats, followed by Jintang, Longlin, Du’an and Chengdu goats (Figure 2E).
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PMC11279598
In the next set of experiments, we investigated a potential mechanism by which Manuka honey was disrupting cancer cell progression.
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PMC9429973
Symptomatic ITP is a severe condition that carries the risk of fatal hemorrhage and is generally treated with corticosteroids and/or IVIG.
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PMC9429973
Studies on morphological changes in peripheral blood smears in COVID-19 and their impact on clinical severity are limited.
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PMC11457557
In addition, TGF-β1, the most abundant isoform of TGF-β, which is released by all types of renal cells and infiltrating inflammatory cells, is a key participant in the pathogenesis of DKD, owing to its intense profibrotic properties.
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PMC9635307
Splenic B cells were isolated by negative selection methods with magnetic beads (MACS®, Miltenyi, Bergisch Gladbach, Germany), and then 5×10 cells/well were incubated with either lipopolysaccharide (LPS, Sigma, St. Louis, MO), anti-CD40 (BD Biosciences) or anti-Igμ F(ab’)2 fragment (Rockland, Limerick, PA) in the presence or absence of CC1 for 48 h. The culture supernatants were harvested to determine cytokine production by enzyme-linked immunosorbent assay (ELISA).
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PMC10758402
This viral enhancing effect was also observed when DMF was administered concurrently with the virus as well as with post-treatment times as long as 8 hours as shown in ( Figure 1D ).
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PMC11803149
Total RNA was obtained from samples using an RNAdvance Cell V2 kit (Beckman Coulter).
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PMC11286266
Figure 1—figure supplement 2.Enrichment method and quality control data analysis by MAGeCK of the CRISPR/Cas9 screens.(A) Two-dimensional contour plots of BiP::sfGFP and XBP1s::mCherry signals in XC45-6S obtained after each sort of enrichment (R1: round 1; R2: round 2) in the screen designed to identify ATF6α activators.
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PMC11180402
Functional assays utilized siRNA knockdown, plasmid-mediated overexpression, and chemical inhibition approaches.
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PMC11377827
A single DUB that significantly counteracted VHL-mediated ubiquitination was not identified in our suppressor screen, as OTUD5 loss only had a very marginal effect on the HIFGFP reporter in 21% oxygen.
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PMC11180402
p < 0.05, ♣p < 0.05 among corresponding groups miR-129 induced by ISO destabilizes SOX2 mRNA by interacting with its 3′UTR.
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PMC11548041
A similar trend was observed for the PLD02-EpEX monomer complex (Figure 2D).
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PMC11758416
For example, we included 2.5 μL of Dynabeads per 5E5 in 1 mL of media per well.
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PMC10788478
β‐catenin phosphorylation by GSK‐3β at Ser/Thr residues, encoded by its exon 3, results in the proteasomal degradation of β‐catenin.
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PMC9429973
Aims: The aim of this study is to describe our experience in treating such a rare ASCT complication.
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PMC11352877
These two transcription factors act as antagonists to each other in the process of angiogenesis.
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PMC11342785
B, identification of TPPP as a candidate module for synthetic engineering using the strategy in (A).
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