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PMC10840195
Then, 100 µL of cells were added to the upper surface of the Transwell chamber.
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PMC11767817
Camptothecin (Sigma Aldrich, St. Louis, MO, USA) was used as a positive control at a concentration of 15 µM. The cells were treated with compounds for 12 and 24 h. The supernatant (necrotic fraction) was collected and stored according to the manufacturer’s instructions.
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PMC9583612
Figure 3 shows the total site-level emissions in basin A and B, disaggregated by three major equipment types typically seen at upstream production facilities—tanks, gas processing units (GPUs), and wellheads.
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PMC9429973
Aims: To describe manageable anemia in patients with HR MDS treated with magrolimab in combination with azacitidine (AZA) in a phase 1 clinical trial (NCT03248479) and further investigate the underlying mechanisms in preclinical models.
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PMC11754094
P = 0.0010 for ABE at TC target compared to the ABE at non-TC target.
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PMC11802929
Hence, by integrating peptide and TCR sequence features, APMAT reveals fundamental rules in the peptide-TCR-phenotype synergy.
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PMC9429973
The third part was about the public health system coverage of procedures and if the gamete cryopreservation of gametes was easily accessible in the same center where the disease was managed.
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PMC11511922
Multiple images per condition were acquired and an image belonging to the “Filipin” group was selected to represent the “Amiloride” condition.
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PMC9516447
Fig. 3GRP78 small molecule inhibitors reduce KRAS protein level in vitro and in vivo.
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PMC5308810
Our data suggested that chemotherapy could establish drug-resistant and tumor-initiating properties of OVC via reversible CXCR4 cell state transition.
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PMC10729469
Compared with untreated AD mice, treatment with TCRAβ-Tregs or polyclonal Tregs reduced numbers of Iba1 + reactive microglia in cortices and hippocampi of APP/PS1 AD mice with greater reductions in cortical tissues produced by TCRAβ-Tregs (Fig. 6A and B).
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PMC8973085
Compounds 4a–4h (10 mmol) were refluxed for 3–6 h in sodium ethoxide solution (0.23 g Na in 100 mL of EtOH).
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PMC8494202
Applying Pearson correlation analysis to the RNA-seq dataset of 748 glioma samples obtained from the CGGA database, we identified 10 genes positively correlated with CKAP2L (BUB1, TTK, KIF14, MELK, ASPM, KIF4A, NCAPG, BUB1B, ESCO2, and SGOL1) and 10 genes negatively correlated with CKAP2L (LDHD, FBXW4, AIFM3, ETNPPL, NOXA1, KNDC1, CYP46A1, LYNX1, MATK, and MYH7B) (Figure 9).
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PMC6133382
We utilized a CRISPR/Cas9 nuclease vector with an OFP reporter (GeneArt, Thermo Fischer Scientific, Waltham, MA, US).
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PMC11538390
This trend contrasts to that in other European countries but its genetic underpinnings are unknown.
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PMC9429973
This proportion was numerically lower in BAT vs RUX nonresponders (69.2% [45/65] vs 79.5% [31/39]).
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PMC9429973
Identification of DUX4-r was not possible using t-NGS.
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PMC11209164
Luminescence was read using a Cytation microplate reader at an appropriate sensitivity.
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PMC11407042
Culture at 37°C with 5% CO2 and 95% humidity.
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PMC5716223
1Cell growth, viability, enzymatic activities and JNK phosphorylation in L6C5 myoblasts under serum starvation condition.
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PMC9429973
The clinical efficacy of asciminib is demonstrated by the high proportion of pts achieving durable MMR and BCR::ABL1 ≤ 1%.
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PMC9822769
The overall scenario is in agreement with what Wexselblatt and Gibson observed for similar complexes .
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PMC11694066
To do so, we first established a PDX model from the primary peritoneal tumor of an 11-year-old male patient with DSRCT and subsequently created a PDX-O, referred to as GR_13, in which we assessed the sensitivity to PARPi, ATRi, and the combination of both agents (Fig. 2E; Supplementary Fig. S8).
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PMC9429973
In addition, TGF-β increased αSMA expression in BM-MSC from healthy donors.
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PMC11703992
Normalization process was conducted via “LogNormalize” method with a scale factor of 10,000, after which the top 2000 varied genes were identified.
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PMC11343332
The cells were maintained at 37°C in a moist atmosphere with 5% CO2.
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PMC11718817
These data have to be correlated with cytotoxicity data presented in Figure 4, as seen below, and show quite remarkable homology of patterns when comparing groups in the presence and absence of nigericin stimulation.
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PMC11679033
Negative and solvent controls had acceptable values compared to historical controls .
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PMC11687167
Their previous experimental studies demonstrated that L-IFPTA + vaccine-mediated inhibition of PCSK9 moderately suppresses tumor growth and improves lifespan and survival in mice with breast and colon cancers .
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PMC9429973
After knockdown of ZNF217 in Karpas1106P and L428 cells, we demonstrated altered proliferation, migration, and apoptosis.
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PMC11474209
The alert level framework is less applicable to cylindrospermopsin as it may be actively released by cyanobacteria cells, so cyanobacterial biomass is a poor indicator of this toxin .
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PMC11098378
We cloned these six effectors into a novel expression vector, pDGOpIE2, along with Flag epitope tags (Fig 3B).
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PMC9895440
Both cells were then mixed at a 1:1 ratio and incubated for 5 min at 37 °C.
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PMC11394227
Reduced glutathione (GSH) is involved in various redox reactions through its sulfhydryl group (-SH), which can remove free radicals and other oxidants, thereby protecting the cell from oxidative damage.
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PMC11144200
The research received approval from Hainan Medical University’s institutional ethics committee.
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PMC11502327
Tumor cell killing experiments showed that PTX-loaded sterically stabilized SLN showed dose-dependent cytotoxicity to SKOV-3 cells, with 15% higher lethal energy than PTX at the same dose, and the ICso value was about 20uM. In other tumor cells, SLN also acts as a coat to participate in a variety of natural drug conjugates, synergistically participating in targeted drug delivery and inducing tumor cell apoptosis.
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PMC11627060
This research examines the cytotoxic consequences of thymoquinone-loaded bovine serum albumin nanoparticles (TQ-BSA NPs) on the A549 lung cancer cell line.
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PMC9024365
GluK2 is predicted not to associate with SD4 and served as a negative control.
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PMC11046454
For all primary CAR T cell testing, three independent experiments were performed using human peripheral blood mononuclear cells (PBMCs) collected from at least two donors.
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PMC11672142
Such speciation may not occur in the context of how the ligand interacts with the LIP due to rapid metal turnover (Figure 2).
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PMC11792740
For instance, immune checkpoint inhibitors (e.g., PD-1/PD-L1 and CTLA-4 inhibitors) can counteract tumor-suppressive effects on T cells, thereby reinvigorating their depleted function .
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PMC11224206
Moreover, responses were sensitive to the ambient temperature which led Song et al. to put forward the radical hypothesis that warm-blood animal cells could adjust their thermal conductivity according to the ambient temperature to promote their own cellular heat balance, akin to the whole body.
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PMC8873393
A Distribution of CDS sizes for “recovered genes” and “non recovered genes”.
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PMC9429973
Results: As of 10 January 2022, 14 patients were enrolled in the IDHm cohort.
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PMC6222726
Endemic to Mexico, this species inhabits tropical deciduous forests at altitudes of 500 to 1600 m of the Balsas and Papaloapan river basins in the states of Mexico, Michoacan, Guerrero, Puebla, Morelos, and Oaxaca.
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PMC10812665
One explanation may be differences in affinity and cellular distribution.
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PMC11335267
The intra- and inter-assay coefficients of variation are 4.82% and 4.8%, respectively, for samples in the range of ~ 39 pg/ml.
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PMC10748106
Since the actual chemotherapeutic treatments are not selective and, in many cases, cancer cells have developed resistance to them, finding new anti-cancer compounds with desirable selectivity toward cancer cells is crucial nowadays .
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PMC9532503
The affinity eluent was collected as a single fraction (step elution) starting from 50 mAU ascending until 50 mAU descending.
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PMC11300639
All animal experiments were examined and approved by the Institutional Animal Care and Use Committee (IACUC) of the Second Xiangya Hospital, Central South University (animal license number 20230474).
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PMC11798926
Nuclei and insoluble material were pelleted with centrifugation at >13,000xg for 15 min at 4°C.
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PMC9429973
CK2 could regulate also BCL2 family members.
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PMC11637276
In fact, p38 inhibition was reported to prevent dextran uptake in dendritic cells , while α5β1 integrins and α6β1 have been shown to localise to macropinocytic cups and macropinosomes, respectively.
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PMC11240571
Western blotting of mouse-derived PD-L1 was not performed because anti-mouse PD-L1 antibodies cannot distinguish between human and mouse PD-L1 (Supplemental Figure S3C).
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PMC11779876
a illustrates TRBC clonality in relation to the maturation stage of the lymphoma cell of origin.
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PMC11583010
Shown are the apparent mean EC50 values obtained and their calculated ratios for each cell type.
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PMC11720808
The cell lines 143B (G) and MG63 (H) were maintained with 100 μM SCU, then TRAF6 (green) and TLR4 (red) colocalization was determined by immunofluorescence.
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PMC11699465
Adapters were removed and low-quality reads were filtered out.
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PMC11297139
The colors indicate normalized gene expression.
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PMC9926039
Therefore, AutoDockTools (v. 4) was utilized to analyze the interactions of methadone with human TLR4/human MD-2 complex to explore the conformation of ligand binding sites.
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PMC11001582
The use of ATG-driven translation, rather than RAN translation, in our models would likely lead to higher translation efficiency and thus potentially higher DPR levels in our mice.
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PMC8633974
They were characterized and tested for antiviral efficacy. (
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PMC11721096
Coffea arabica L., which belongs to the Rubiaceae family, is one of the most popular drinks worldwide.
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PMC11307990
To achieve an optimized stoichiometry, a defined amount of DNA origami nanostructures was mixed with varying concentrations of chitosan oligosaccharide lactate (MW ≈ 5 kDa) at a specific N/P charge ratio (N/P values ranging from 0.01 to 0.4) (Table S1, Supporting Information).
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PMC11098378
Although arboviruses are well-adapted to replicate in dipteran and mammalian hosts, we have previously shown that several arboviruses, such as VSV and SINV, undergo abortive infections in cells derived from lepidopteran (moth and butterfly) hosts .
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PMC10988555
Cobalt is an essential trace element for humans, playing a vital role in several critical biological processes, being mainly found in the form of vitamin B12 (cobalamin).
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PMC11707577
Despite the many benefits demonstrated in the employment of TNPs in nanomedicine, their use is still hampered by intrinsic limitations: i) it is well known that the shape of a nanoparticle has a crucial role in controlling the cellular uptake and the permeation of physiological barriers, but in the case of synthetic methodologies used for TNPs only spherical nanoparticles are commonly obtained, , , ii) as for all nanoparticles, even if more and more precise synthesis techniques are being developed, intra‐ and inter‐ batch variability issues persist, , iii) TNPs do not have intrinsic target abilities against specific cells.
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PMC11799978
While these studies uncover that the acidic TME promotes tumor growth via dampening the antitumor immunity of T cells, our data reveal that the pH of culture medium directly regulates the plasticity of CAFs.
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PMC11783017
143B cells were harvested and suspended in PBS at 4 °C.
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PMC11628904
For experiments involving exposure to C. albicans, Tg(LyzC‐BFPxMpeg1.1‐mCherry) larvae were used.
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PMC9856122
proved to have anti-HSV activity in the Bragg albino mouse model (BALB).
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PMC9429973
Most common mutations involved ASXL1 (8/66 pts; 12%), DNMT3A (4/66 pts; 6%) and RUNX1 (3/66 patients; 5%).
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PMC8711270
Although most biotherapeutics are produced in animal cell lines, production in human cell lines is expanding.
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PMC5673955
Levels of β‐Gal gene expression were normalized relative to the expression of reference gene 18S. (
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PMC11760643
Analysis of CD8 T cell subsets showed greater expression on T cytotoxic 17 (Tc17) cells (402.0 ± 73.9) compared with total CD8 T cells (204.8 ± 33.4; p = 0.05; Figure 3D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Usually, the prevention of these complications uses Bisphosphonates (BP).
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PMC9065483
Figure 2Inhibition of the EGFR pathway abrogates vanadate-enhanced viral infectivity(A) Human 786-0 renal carcinoma cells were pre-treated with or without vanadate (150 μM) and varying concentrations of gefitinib (0–50 μM) as indicated for 4 h. Cells were then treated with 10 ng/mL EGF for 10 min and lysates were probed by western blot for phosphorylated EGFR, total EGFR, and β-actin. (
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PMC11549062
The migration ability of the cells was analyzed based on the extent of healing observed in the scratched area.
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PMC11519567
We co-overexpressed the SS18-EGFP and SS18-SSX1-mCherry proteins within BJ cells, which were later treated with 1,6-hex and high temperature.
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PMC11747467
Regardless of the classification system (UNC, MDA, TCGA, or Consensus subtype), we found that patients with the basal type had worse outcomes than those with the luminal subtype ( Supplementary Figures S1A–D ).
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PMC3915447
The difference among various groups was analyzed by ANOVA test, and P-values of less than 0.05 were considered significant.
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PMC11656380
The time course of cell death induced by Tat-Ram13 or etoposide in CCRF-CEM cells.
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PMC11394730
It has been noted that trans-resveratrol and its glucoside provide a variety of benefits, such as anti-tumor, cardioprotective, anti-oxidative, and anti-inflammatory qualities .
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PMC9429973
11 of 16 (69%) patients achieved hematologic improvement in ≥1 lineage.
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PMC11352311
However, the emergence of resistance to immunotherapy has necessitated the ongoing investigation of novel drugs to address the challenge of drug resistance in RCC .
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PMC2118063
5 μg of plasmid expressing EGFP or IRF8 tagged with EGFP (17), both gifts from K. Ozato (NIH, Bethesda, MD) was added to each tube and run on the U-15 program of the Amaxa nucleofector machine.
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PMC6642070
Lactate is widely accepted as a nociceptive substance.
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PMC11725127
To further confirm that USP2 is a target of GA, the lysates of MM.1S and RPMI 8226 cells were incubated with biotin-GA, followed by precipitation with streptavidin-coated agarose beads and gel electrophoresis.
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PMC11507371
Conversely, A431 cells exhibit increased basal nuclear Nrf2 localisation as an adaptation to intrinsic ROS elevation, allowing only minimal enhancement after CAP exposure.
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PMC11453018
To investigate this, we retrieved ChIP-Seq data in which EWS::FLI1 was overexpressed in MSC to promote malignant transformation .
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PMC10587429
The animal study was approved by The New York Medical College Institutional Animal Care and Use Committee.
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PMC9792775
Recently, ultrasound has become an effective clinical technique for adjuvant targeted therapy.
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PMC11772449
The results showed that knockdown of p38γ expression could enhance the inhibitory effect of Sora on the proliferation of hepatocellular carcinoma cells compared with the control cells transfected with si-NC (Fig. 2 A-F).
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PMC11739670
Binding of CD8αβ to HLA‐A2(H114R/Y116D/K127) or HLA‐A1(R114H/D116Y/N127K) compared with wild‐type was assessed by SPR.
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PMC10873328
The area under the curve for four diagnostic models. (
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PMC9429973
Summary/Conclusion: Non ABL1 KD mutations are closely related to TKI efficacy and disease progression, while WT1 and RUNX1 mutations may be new molecular targets for accurate diagnosis of CML.
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PMC2614415
The Aurora family of evolutionarily conserved serine/threonine kinases regulates entry into mitosis, centrosome maturation and the mitotic spindle checkpoint .
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PMC5034105
The fixed cells were incubated with mouse antiserum against the ZIKV- or DENV-2-NS1 protein, followed by FITC-rabbit anti-mouse IgG (Invitrogen, Carlsbad, CA, USA).
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PMC9429973
When censored for allo-HCT, OS trended longer with Quiz vs PBO (HR, 0.752; 95% CI, 0.562-1.008; 2-sided P=0.055).
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PMC11794568
Cytotoxicity assays were performed to assess the half inhibitory concentration (IC50) of rotenone on CRIP1-silenced SK-MEL-2 and A375 cells. (
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