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OTAR3088
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PMC5963610
To address this hypothesis, we explore the impact of combining an anti-EGFR mAb with either active (NGcGM3/VSSP vaccine) or passive (14F7 mAb) therapies targeting NGcGM3.
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PMC11577421
The binding stoichiometry, representing the number of adsorbed proteins per NP, was determined using the Micro BSA Protein Assay Kit.
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PMC5308810
The cells were isolated by flow cytometry using APC-labeled CXCR4 antibody. (
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PMC8998437
In the type III BL cell lines BL18 and Mutu cl.99, CCR1 mRNA expression reached the level detected in the LCL-1year cells: the CCR1 transcript copy number per 1000 copies of the TBP transcript was 1130 ± 102 copies and 1080 ± 184 copies, respectively.
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PMC7823217
An immersion bioprinting technique has also been practiced in patient-derived GBM and sarcoma biospecimens, which can mitigate the limitations of patient derived tumor organoids(PTO) for drug screening .Fig.
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PMC11448304
Size of the letter shows the frequency of the amino acid residing at the position Properties of the identified Khib peptides.
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PMC9429973
With a median follow up of 8.1 months (range 0.3-21) and including only IMWG confirmed responses, overall response rate (ORR) was 64% (95% CI 50-75%), and 31% of pts achieved complete response or better.
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PMC11634027
Plasmids encoding different Ds-ICD motif deletion constructs with a C-terminal V5-tag were created in this study: pUAST-Ds-TM-ICD-ΔA:V5, pUAST-Ds-TM-ICD-ΔB:V5, pUAST-Ds-TM-ICD-ΔC:V5, pUAST-Ds-TM-ICD-ΔD:V5, pUAST-Ds-TM-ICD-ΔE:V5, pUAST-Ds-TM-ICD-ΔF:V5, pUAST-Ds-TM-ICD-ΔD-I:V5, pUAST-Ds-TM-ICD-ΔD-II:V5, pUAST-Ds-TM-ICD-ΔD-III:V5, pUAST-Ds-TM-DCHS1-ICD:V5 and pUAST-Ds- D+EGFP:V5.
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PMC11680982
Fig. 5Neratinib enhances the efficacy of CDK4/6 inhibitor combined with endocrine therapy in HR/HER2-low breast cancer in vivo. (
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PMC11323699
Recorded data were analyzed using MO.Affinity Analysis software v2.3 (NanoTemper Technologies).
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PMC11730311
Data points are presented as mean and range of n = 2.
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PMC9429973
Aims: We aim to assess the available literature on the clinical efficacy, safety and real-word effectiveness with HU therapy in LMICs.
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PMC11365427
Western blotting was performed as previously described.
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PMC8922418
It has the advantage of single-base discrimination of target genes (Shmakov et al., 2015).
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PMC11394227
Total RNA was extracted using the TRIzol reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer’s protocol.
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PMC11694066
Dose–response curves for single drugs were fitted to a four-parameter log-logistic model.
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PMC11718274
Excessive generation and accumulation of ROS beyond the basal threshold can induce apoptosis in cancer cells by causing mitochondrial damage.
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PMC11095939
n.s.,
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PMC11106977
In RA, there is a massive infiltration of DCs in the synovium.
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PMC10094992
Derivatization of aldehydes with DCHD.
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PMC8740518
The anesthesia protocol was that provided with the anesthesia machine produced by RWD Life Science Co., Ltd. (GuangDong, China).
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PMC11388384
For cells expressing TetA and (+)-end-directed Espin, cells were cultured in 500 ng/mL Doxycycline.
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PMC11127909
ANT3 belongs to the ANT family, which plays a crucial role in regulating metabolic reprogramming and cell death progression to promote cancer cell proliferation and drug resistance .
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PMC11794568
The relative mtDNA copy numbers in cutaneous melanoma cells with both CRIP1 and TFAM knockdown were determined by RT-qPCR. (
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PMC8524093
Notwithstanding, newborns are the most susceptible to it.
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PMC11544122
Previous research has suggested that site-specific phosphorylation of CT is a prerequisite for CXCR4 endocytosis.
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PMC9429973
And the increase of ineffective megakaryocytes may be due to insufficient circulating TPO.
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PMC9429973
For subjects aged 12 to <18 yrs who weigh <40 kg, or subjects aged 2 to <12 yrs, dosing according to body weight (≥40 kg, ≥20 to <40 kg, and <20 kg) would yield similar mitapivat AUC ranges between pediatric and adult subjects.
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PMC3019555
Cells were fixed at the indicated times and immunostained for α-tubulin (white).
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PMC9429973
OMA1 activation was required for the therapeutic effect and CRISPR-Cas9 depletion of OMA1 eliminated BTM-3566’s apoptotic activity.
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PMC11637284
P, pellet; SN, supernatant; FT, flow through; IP, eluate of immunoprecipitation.
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PMC6948907
Besides, these compounds can augment the apoptotic effects of other anti-cancer agents by diverse molecular targets (Frew et al., 2009).
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PMC11604830
Of course, also biomedical imaging greatly benefited from these advances.
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PMC9351137
The chromatin remodeling subunits (CRS) studied in this work are depicted in colours Schematic representation of midbody and subunit composition of SRCAP and p400/Tip60 chromatin remodeling complexes in human cells.
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PMC9429973
CML patients with a higher percentage of mature NK cells have increased relapse-free survival after treatment discontinuation.
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PMC9318744
A549 cells were included as a control.
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PMC9429973
When considered as a whole (for the purpose of this study, TN pts were considered has having driver VAF equal to 0), the VAF of driver mutations inversely correlated with survival (HR 0.4 [0.2-0.9], p=.0219).
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PMC9841531
CLog P was determined by using the atomistic method, while TPSA was determined using the fragment-based method.
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PMC10506676
Pathological staining was used to examine changes in cell morphology.
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PMC10551595
Cells were seeded in 96‐well plates and treated with increasing concentrations of GinA. Subsequently, MTT assays were performed assessing the viability of treated cells with GinA in comparison with cells incubated with the solvent, DMSO.
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PMC8584319
The phosphorylation of eIF2α was up-regulated under these conditions (Figure 2b), but the pattern was not consistent with AZD8055-mediated regulation of translational.
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PMC11201989
In this study, we investigated for the first time the role of the immune checkpoint protein and immunological synapse regulator PD-L1 on ciliogenesis.
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PMC10870498
Total RNA from cells was extracted by TRIzol reagent (Invitrogen).
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PMC11782508
Total RNA was isolated from a 1.5 mL aliquot of an overnight bacterial culture (grown for 18 h in an azurin production medium) using the ABT Total RNA Extraction Kit (Applied Biotechnology, Egypt) according to the manufacturer’s protocol.
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PMC11515150
Schematic diagram of the two lentiviral CD5 CAR expression plasmids (top panel) and flow cytometry analysis of CD5 CAR expression on CAR-NK cells versus NT-NK cells on day 14 (bottom panel). (
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PMC10900886
From 2 to 10 hpi, viral titers in the supernatants increased ~1 logarithmic TCID50/mL in imDCs and ~0.5 logarithmic TCID50/mL in mDCs inoculated with EV-D68/A, after which the virus titers decreased.
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PMC11627133
Due to its elevated expression in several cancer types, nucleolin serves as an attractive target for both diagnostic and therapeutic purposes, with AS1411 previously explored in drug‐conjugate studies and as a therapeutic agent.
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PMC11670407
Since OTULIN promotes cell survival in some cases , the relationship between OTULIN and chemoresistance in OS deserves attention.
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PMC10729469
The TCR identified from Aβ-Teff clones were used to design TCRAβ plasmid constructs for lentiviral transduction of Treg recipient cells.
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PMC11726183
Using a separatory funnel, the filtrate solution was extracted multiple times with hot water to obtain a clear solution indicative of the clearance of isatin.
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PMC11377827
Cells were washed twice in 1x DPBS, permeabilised with 0.1% Triton for 10 min, washed again, and blocked in 4% FBS in 1x DPBS.
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PMC11545737
The use of butyrate-decorated liposomes carrying 4-OI (4-OI/Blipo) in NCM460 cells, treated with TNF-α to trigger the activation of caspase-3, reduced cell death, GSDME-N levels and re-established the levels of tight junction proteins.
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PMC9429973
Median OS was not reached (42.3-NE) for patients with 1 PL (n=546), was 26.2 (21.7-35.7) for patients with 2 PL (n=380) and was 12.1 (7.6-25.0) for patients with 3 PL (n=102).
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PMC11300085
SK-OV-3 cells undergo morphological elongation characterized by epithelial-to-mesenchymal transition (EMT) and Ras homologous genome members A (RhoA)/Rho protein-related curl spiral kinase-1 (ROCK1) activation.
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PMC9429973
Median age was 66 years (range 38-87), median prior therapies was 2 (range 1-5), 40 pts (58%) received ≥2 prior therapies, 45 pts (65%) were POD24, 21 pts (30.4%) were refractory to last therapy, and 28 pts (41%) had tumors ≥5 cm.
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PMC11185260
XTT cell viability assay at 48h after transfection.
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PMC9429973
Cardiac involvement is commonly observed and has a major impact on prognosis.
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PMC9429973
The time interval between previous radiotherapy and lymphocyte collection had a significant effect on 3-month CR, P=0.0417.
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PMC11590005
Affirmation of differences’ reflects the idea that black people have characteristics that dif-ferentiate them from white people and make them fit only for jobs that require less formal qualification.
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PMC9429973
Effectiveness of AZA was assessed using IWG 2006.
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PMC11659734
Three‐dimensional (3D) cell culture assays facilitate direct cell–cell contacts and incorporate an extracellular matrix (ECM), making them more representative of in situ cellular responses.
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PMC7192625
The black line shows the diagonal (x = y). (
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PMC11496728
The optimized vectors were transfected into different cell lines, and the transient transfection and stable transfection expression of SEAP were detected, and the relative gene copy number was analyzed. (
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PMC9429973
Results: From November 2016 to January 2021, 457 patients with newly diagnosed CP-CML patients were enrolled into the study and 448 of these (228 and 220 randomized to the NIL and IMA arms, respectively) were evaluable (mean age 54.2 yrs - range 19.4 – 85.8).
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PMC11411004
In addition, it significantly increases the intracellular expression levels of H3K4me2, Ac-H3K9, and Ac-H3K27 proteins.
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PMC11650848
Statistically significant values are marked as: single asterisk indicates p < 0.05, triple asterisks indicate p < 0.001 conducted by student t-test.
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PMC11512230
The mean hydrodynamic diameters determined by the nanoparticle tracking analysis were in the range of 107–114, 182–186, and 113–124 nm for TMV SP, AltMV SPV, and AltMV SPVLP, respectively.
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PMC10728535
Furthermore, the clustering patterns of the sample were assessed by presenting the results by PCA plots.
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PMC11461874
Precise regulation of expression levels (and activity) of PAR-bZIP/E4BP4 proteins is critical for rhythmic transcriptional activity of D-box.
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PMC10745221
While this study compared the abundance of SDMA and ADMA on proteins between various human cancer cell lines, a similar comparison among primary tumors in different tissues may produce distinct results.
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PMC4355729
Cells were lysed with radioimmunoprecipitation assay buffer (Beyotime Biotech).
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PMC9100622
We further observed that the inhibition of the MVA pathway had pleiotropic effects on Ewing cells.
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PMC10568263
Subsequently, the LC/Au@MnO2/MoO3/SPEs were placed in 20 μL of EDC/NHS (EN) mixed solution (4 mM EDC and 1 mM NHS) at 37 °C for 1 h and then washed with DI water.
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PMC11502443
For each signaling molecule, the Emax was constrained to the maximal normalized response by any agonist across the entire dataset and n was set to 1.
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PMC11127909
These results suggested that EFHD1 mediated OS chemoresistance by fixing ANT3 in the m-state to inhibit mPTP opening.
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PMC10094712
The resulting time-lapse series of images were processed using ImageJ software (Java 1.6.0_12, RRID: SCR_003070, LOCI, University of Wisconsin, Madison, WI, USA).
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PMC11474209
One aspect of the global issue evaluated by the GLOBALHAB Status Report is the occurrence of harmful algal blooms (HABs) in the United States.
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PMC11271278
In the aforementioned five cell lines that harbor ecDNAs or chromosomal complex amplicons, we observed both “opportunistic” (COLO320DM and NCIH2170) and “mutualistic” (MCF7, SNU16 and NCIH446) enhancer hijacking phenomena among multiple oncogenes on the same amplicon, which are associated with overexpression of the associated oncogenes (Fig. S8A).
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PMC11519788
Further studies should be performed to investigate this hypothesis.
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PMC6684588
Together, the inherent pharmacokinetic properties of the Fc domain, the paired HBS, and rapid proteolytic cleavage in the circulation promote localized action of ACE-083 in injected muscles.
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PMC11607764
This discrepancy may be attributable to the different normal tissue sources used in TCGA (adjacent normal) and GTEx (non-tumor tissue), as well as potential batch effects between the 2 datasets.
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PMC9429973
Results: At the data cut-off date of 1/31/2022, 189 patients underwent leukapheresis; 167 (88%) completed infusion and 22 (12%) did not (manufacture failure n=7, death n=6, disease progression n=5, organ dysfunction n=2, complete response [CR] to bridging therapy n=1, patient decline n=1).
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PMC10218459
The effects of the combined application of CPP and chemotherapy on Ewing’s sarcoma cells in this study appear to be based on additional effects of the individual methods.
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PMC9100622
Moreover, in agreement with the MVA pathway being regulated by the EWSR1-FLI1/EGR2 axis, the global expression of 16 MVA pathway enzymes, and specifically the 2 rate-limiting genes HMGCR and HMGCS1, was significantly higher in Ewing cell lines as compared with other cancer cell lines (Figure 3B and Figure S2A).
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PMC11732628
miR-490-3p, micro RNA-490-3p; RT-qPCR, real-time quantitative polymerase chain reaction; CCK-8, Cell Counting Kit-8; mRNA, messenger RNA; NC, negative control; ns, no significance.
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PMC5716223
Moreover, we show that the NGF-mediated hypertrophic at the late stage of differentiation correlates to an increased expression of MyHC isoforms.
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PMC9429973
Ig use was not associated with overall survival, highlighting the need for contemporary studies to inform patient selection, especially with rising use of Ig and targeted anti-myeloma therapies, and a high burden of infection-related mortality.
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PMC11621565
Statistical analyses used fold-change calculation as fold increase to control followed by statistical significance testing (One-Way ANOVA followed by Dunnett’s Test), *p < 0.05, **p < 0.01, ***p < 0.001.
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PMC10858941
Membranes were blocked with 5% milk and incubated overnight with primary antibodies.
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PMC11420784
P values were determined using Student t test.
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PMC11701801
E, Expression of CASP6 mRNA (relative to that in siNT-transfected cells) in SMARCA4/SMARCA2-deficient and SS18–SSX fusion cells transfected for 48 hours with the indicated siRNAs.
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PMC11185260
Figure 2scL-SMARCB1 nanocomplex restores SMARCB1 expression in SMARCB1-deficient rhabdoid tumor cells. (
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PMC11400680
Overview of the proposed instance segmentation model consisting of three parts: (I) prompt generator; (II) segmentation model; and (III) mask refinement.
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PMC8592717
A single dose of 5 and 10 mg/kg PCA intraperitoneal injection (i.p.)
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PMC10538569
Importantly, the CD4 receptor has been found to be located within lipid rafts of plasma membrane (35, 36).
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PMC10874773
dunnianumBai et al., 201215Dunnianolide BI.
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PMC6617630
First, we assessed the effect of low doses (0.5 and 1.0 μM) of the JQ1, I-BET, and OTX on DHL and THL cells along with WT-MYC cells.
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PMC11802855
Correlations between the co-expressed gene modules from WGCNA and pathway activation were examined.
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PMC11721587
The primers for amplifying DNA template for dsRNA transcription are as follows.
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PMC10589262
HSP90 inhibitors have a different mechanism of action from kinase activity inhibition, such as that seen with imatinib.
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