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OTAR3088
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PMC11767725
Metabolic dysfunction exacerbates this dysbiosis, creating a skin environment conducive to pathogenic microbial overgrowth.
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PMC10854447
H NMR (400 MHz, δ ppm DMSO-d6): 8.81 (s, 1H, triazole-CH), 8.05 (q, J = 4.8 Hz, 2H, Ar–H), 7.90 (d, J = 7.4 Hz, 2H, Ar–H), 7.48 (t, J = 7.4 Hz, 2H, Ar–H), 7.39 (q, J = 8.6 Hz, 3H, Ar–H), 6.30 (s, 2H, N–CH2).
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PMC11484188
Multiple myeloma (MM) is the second most common type of hematological malignancy globally.
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PMC10317042
Almost all tested drugs were ineffective against CCS (Supplementary Fig. S1A), but 26 drugs resulted in a cell viability of <30% (Supplementary Fig. S1B).
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PMC11615101
The bar graph shows that the STX4 protein level increased as we increased the dose of α-Taxilin based on the densitometric value. (
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PMC11786704
Chunwu Zhang: Writing – review & editing, Writing – original draft, Validation, Methodology, Investigation, Data curation, Conceptualization.
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PMC11247842
The third strongest association signal was located on BTA20, with BTA20: 22,386,425 (rs380944374) as the lead SNP, which is an intron variant of MAP3K1.
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PMC11683240
This is because toxins produced by B. pertussis rather than the bacterium itself cause the majority of disease manifestations.
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PMC11731614
Mice were fed 42% fat (Envigo TD88137) for 10 weeks as a rodent model of type 2 diabetes.
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PMC3019555
Visualization of cytoplasmic GE-1 and Ago2 revealed that 100% of Ago2 foci colocalized with GE-1 (Fig. 4 B, arrows).
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PMC11711127
Effector T cells (CD4+, CD8+, Treg cells) are short-lived populations that originate from the expansion and differentiation of activated T cells.
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PMC11721096
As shown in Figure 7A, the safe concentration range for these compounds in B16 melanoma cells was determined to be between 1 and 25 μM. All the compounds except 4 showed an obvious toxic effect at 50–200 μM. In contrast, compound 4 and the positive control kojic acid were safe enough even at 200 μM. Subsequently, the inhibitory effect of these compounds on tyrosinase activity in B16 cells was evaluated.
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PMC11632064
We also analyzed transcripts encoding putative off-targets of BI-D1870, a notorious nonselective RSK inhibitor (reviewed in Wright and Lannigan ).
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PMC11476666
Densitometric analyses were performed with the Fiji software .
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PMC10605143
Unlike MCF10A cells, which are mainly CD44/CD24, MCF12A cells exhibit the CD44/CD24 phenotype (Figure 4b), which is associated with a mesenchymal phenotype.
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PMC10380508
Moreover, PAX2 and PAX8 are potential oncogenes in RCC .
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PMC11790971
To avoid overfitting, the MLP classifier’s architecture was constrained to a single hidden layer with 25 neurons.
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PMC10728200
This suggests that K191 is a key regulatory site for GPX4 ubiquitin modification catalyzed by STUB1.
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PMC11670407
Next, to facilitate subsequent experiments, we used a lentiviral plasmid to construct 143B and U2OS OTULIN-knockdown cell lines.
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PMC11755467
This indicates that other factors such as RNA structural or sequence-dependent features might play a role in Enoxacin-mediated RNAi modulation or might explain the observed insensitivities to the drug.
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PMC7039683
In conclusion, as DeltaSVM indicates that the risk-variant of SNP2 significantly lessens the periderm-enhancer score of the element containing it, SNP2 is the top-candidate for a functional SNP at this locus. (
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PMC11075223
Hitherto, 348 constituents have been isolated successfully from Cimicifugae Rhizoma, mainly triterpenoid saponins, phenylpropanoids, chromones, alkaloids, terpenoids and flavonoids.
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PMC10850553
The images of immunofluorescent staining of kidney with glomerulonephritis for C3 (green), C5 (green), C5b-9 (green), Thy1.1 (red), and merged images with nuclear staining by DAPI (blue) are shown.
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PMC10988555
This ability could be related to the oxidation and reduction processes that may occur for cobalt complexes in a hypoxic environment, since the Co(III) reduction to Co(II) typically occurs between 0.4 and −1.28 V for this type of complexes, reduction potential of the cytoplasmic environment of the cell is −0.298 V. Evaluation of the production of reactive oxygen species (ROS) in A2780 cell line after 48 h of exposure to the IC50 of the complexes 2–4 by flow cytometry.
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PMC9429973
Image: Summary/Conclusion: Camrelizumab combined with GEMOX chemotherapy showed encouraging clinical efficacy and tolerable toxicity in R/R HL patients and merited further study.
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PMC11190538
Yoghurt contents were thoroughly mixed with a sterile spatula, serial dilutions were prepared and 20 μl of the suitable dilution was cultured in 20 ml MRS agar.
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PMC9429973
Results: Overall, 944 blood cancer patients responded (173 MM, 93 leukaemia, 117 lymphoma and 561 with a myeloproliferative neoplasm).
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PMC11040965
Compared with plasma cells from MGUS patients, those from MM patients have very low levels of miR29b, high levels of DNMT3B, and more methylation of proteasome subunit gene promoters.
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PMC8806312
Neutrophils might play an essential role in tumor progression and development by providing a suitable microenvironment for their growth, thus serving as biomarkers for inflammation and as therapeutic targets .
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PMC11286266
Selected pathways are ranked by p-value.
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PMC11615828
There are several possibilities to explain this incomplete vesicle immobilization.
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PMC11457557
Evidence suggests that inherited factors and acquired elements accumulation of Advanced Glycation End products (AGEs) known as “metabolic memory” have been crucial in developing T2DM-induced DKD in recent years .In addition, many non-modifiable risk factors for DKD, including ethnicity and genetics, have been documented .
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PMC11252033
ASA-treatment determined a downregulation of Bcl-2 and Bcl-xl mRNA levels in A2780S and A2780R cells.
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PMC11764090
Dong et al. (2019) discovered the regulation of leaf-derived jasmonic acid as a long-distance transport signal to regulate water uptake by cotton (Gossypium hirsutum L.) roots and invented a liquid fertilizer that promotes jasmonic acid synthesis under partial root-zone irrigation to cope with drought .
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PMC9412887
Additionally, a summary of nanomedicines studied for overcoming chemotherapeutic resistance in recent years is displayed in Table 2.
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PMC11635519
Root-mean-square deviation (RMSD) of the heavy atoms of PepA, PepA2, and PepA3 bound to the GLP-1R. (
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PMC9429973
Leukemia cells with stem cell features (“leukemic stem cells”, LSCs) residing within MRD are thought to be at the origin of relapse.
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PMC9429973
The median follow-up of the whole cohort of patients is 30.4 mo.
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PMC11361748
We focused on up-regulated genes (>8-fold; adj.
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PMC9429973
After activation, the proportion of PS+ platelets in CG was ≥ 5%.
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PMC6442998
Genomic DNA was removed using the RNase- Free DNase set (Qiagen).
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PMC11653533
It typically grows to a height of 6.9 to 10 m. As one of the oldest cultivated fruits in the Mediterranean region, it produces two crops each year.
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PMC11577421
Anisotropy measurements are advantageous for being unaffected by sample dilution and first-order inner-filter effects.
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PMC9516401
Standardization of the extracts of P. vulgaris , C. colocynthis , P. oleracea , A. cepa , and C. verum The extracts of P. vulgaris, C. colocynthis, P. oleracea, A. cepa, and C. verum were standardized based on the content of phenolic compounds.
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PMC11534035
Twenty-four hours after seeding, the wells were treated with 100 μl of medium containing either G1, G36, or the ethanol control.
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PMC11683130
The release of LCN2 and MPO during neutrophil degranulation exacerbate skin inflammation in psoriasis by participating in the activation of neutrophils (154, 159).
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PMC11746948
RT-qPCR analysis of ZDHHC20 (c) and GPX4 (d) mRNA levels in A375 cells infected with lentiviruses encoding control shRNA or ZDHHC20 shRNA.
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PMC11371627
CSF flow cytometry.
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PMC11653533
Its bark is greenish white, where leaves are primary, interchange, and regularly organized in clusters at the closes of branches along with 5–12 cm wide and 10–18 cm long stipulate with whole, broadly elliptic to praise (Abdul, 2017).
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PMC11583010
A, PK analysis of ETx-22 [ADC + total antibody (tmAb)] by Meso Scale Discovery technique.
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PMC10820104
After treatment for 24 h and harvesting via trypsin, the cells were washed with D-PBS.
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PMC8875242
In addition, multiple regulatory agencies list digoxin as a suitable ABCB1 substrate that can be used to test for clinical DDI .
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PMC10440586
All patients were newly diagnosed as WHO grade II and had at least 5 years of follow-up.
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PMC11607764
Furthermore, we explored the frequency and types of PTBP1 genetic alterations in cancers.
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PMC11457557
Multiple heritability studies conducted earlier have proved a vital link in the family-based studies in DKD.
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PMC7057940
ES A673 cell line [CRL-1598; American Type Culture Collection (ATCC)] was cultured in Dulbecco's modified Eagle's medium (DMEM; cat.
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PMC9964635
Upon reaction completion, n-hexane was added to afford arylated derivatives as precipitates which were further purified with an ethanolic recrystallization process or column chromatography technique using ethyl acetate–petroleum ether (1:9).
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PMC11536589
PKF-118-310, a small molecule antagonist of the β-catenin/Tcf4 complex, repressed the MGST1 expression, and induced MRTX1133-resistant PDAC cells ferroptosis.
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PMC9429973
100% donor chimerism was formed on day 278.
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PMC11711127
Recently, a fourth signal has been proposed.
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PMC9429973
Aims: This study aims to assess the importance of DNA damage response pathways in T-cell acute lymphoblastic leukemia cancer (ALL).
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PMC11323699
Multiplex immunofluorescence staining (CD4, CD8, FOXP3, CD68, CD163) and image analysis were conducted as previously described .
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PMC11615743
However, they distinguish themselves by forming a left‐handed double helix upon hybridization with a matching L‐DNA sequence.
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PMC10568263
A multi-mode microplate reader (Synergy HTX, BioTek, Winooski, VT, USA) was used to read the fluorescence and excitation/emission was 560/590 nm.
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PMC11585565
Three variants are located within the extracellular domain, nine within the DUF21 domain, nine within the cystathionine β-synthase (CBS) domain, and seven within the cyclic nucleotide-binding homology (CNBH) domain (Fig. 1b).
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PMC11495567
Images were captured at the onset (t = 0), and every 24 h for up to 144 h using the Nikon Ti Eclipse microscope at 4X magnification.
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PMC11477621
To date, four HDACis, vorinostat (SAHA), belinostat, panobinostat, and romidepsin, have gained US Food and Drug Administration (FDA) approval for the treatment of refractory or relapsed cutaneous and peripheral T-cell lymphomas or multiple myeloma.
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PMC11473750
Protein lysate was standardized using the BCA protein quantitation assay kit as per manufacturer’s instructions (Thermo Fisher Scientific), and 20–40 µg whole protein lysates were resolved on 10–14% Tris-HCl Criterion gels (Bio-Rad).
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PMC11085211
Arbutus unedo L. (A. unedo) is a Mediterranean plant used in traditional medicine to treat various illnesses, such as gastrointestinal, dermatological, cardio-vascular, and urological disorders, kidney diseases, or also used as a diuretic and antidiabetic, suggesting the presence of numerous NPs with promising pharmacological activities .
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PMC10452486
The clusters of HLA-C on the cell surface were larger than for HLA-B, revealing that different loci exhibit distinct nanoscale organizations at the cell surface.
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PMC11775197
Moreover, an imbalance in CSCs is associated with malignant tumors’ advancement and developmental potential.
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PMC9065483
Notably, the clinical regulatory approval of talimogene laherparepvec (T-VEC), a genetically engineered herpes simplex virus (HSV-1) for the treatment of melanoma, has unveiled the potential of OVs as a staple cancer therapeutic in years to come.
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PMC11764090
Exogenous MET application can increase the expression of CBFs, COR15a, ZAT10 and ZAT12, thereby improving the growth and cold tolerance of A. Thaliana (Figure 2).
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PMC11473750
4The RNF121 transmembrane domain 5 is required for growth and clonogenicity in vitro.a Top panel: Cell viability analyses (n = 3) of SK-N-BE(2)-C and Kelly human neuroblastoma cells transfected with RNF121 siRNA-1, RNF121 siRNA-4 or Control siRNA for 96 h. Two-sided unpaired Student’s t-tests were performed to derive p-values.
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PMC11684297
On the other hand, after treatment with ZnO-NFs, the cells were shrunken with a black-colored deposition in the periphery of the cell membrane, indicating damaged cells.
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PMC11638255
For (b) and (c), data are n = 11 (Saline + IgG2a) or n = 10 (all other groups) biological replicates, one independent experiment.
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PMC11679033
HEK293 and HepG2 cells were grown in EMEM medium (Sigma-Aldrich, Steinheim, Germany) supplemented with 10% (v/v) FBS, 2 mM glutamine, 1% (v/v) PenStrep and 1% (v/v) NEAA.
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PMC11759751
In combination with prednisone, etoposide and lenalidomide, the ORR reached 73.5% and the median OS was 19.3 months in elderly patients with R/R DLBCL .
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PMC11783017
After intratumoral injection, the hydrogel can gradually degrade under the high ROS conditions in the TME and release the targeted MYC therapy drug (NHWD-870) and Cis/Mn@Lipo-IL11.
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PMC9429973
The disseminated intravascular coagulation (DIC) was found in the majority of cases (72% of cases).
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PMC9429973
However, prevalence data were too sparse to provide consistent prevalence numbers per region through meta-analysis.
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PMC10958426
In brief, 4ul PBS was added to each well of a 96-well plate.
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PMC11680049
In the suspension culture of Sequoia, the formation of individual or cell aggregates was noted, in which secondary metabolites accumulated.
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PMC11739504
As a result, IFT25 and IFT52 were found to be abnormally positioned.
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PMC11476004
Song et al. and Miller et al. found no effect of sex on squamous cell carcinoma.
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PMC11767817
Under these conditions, JC-1 cannot reach a sufficient concentration to form J aggregates and emits monomer green fluorescence at 530 nm .
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PMC8557138
Ehsan et al. constructed a pre-vascularized tumor model by incorporating spheroids of endothelial cells and either cancer cells including MCF-10A, MDA-MB-231, A549, SW620 in fibroblast containing fibrin matrix.
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PMC9118379
In contrast, adopting the CMSe-gFDR strategy, we further used MAYU to process the combined results from iProphet for validation at a gFDR of 1% and manually extracted variant peptides from the PSMs passing MAYU’s validation.
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PMC10900886
Clonal B cell cultures from each donor were generated using limiting dilution.
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PMC10329074
Secondly, the R survival package (version 3.2–10; https://cran.r-project.org/web/packages/survival/) was employed for statistical analysis of survival data, and R survminer package (version 0.4.9; https://cran.r-project.org/web/packages/survminer/) was utilized for data visualization.
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PMC11469524
Fig 5D and S2 Table).
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PMC11789597
The dead cells were stained using SYTOX Blue dead cell stain (Thermo Fisher Scientific).
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PMC11334037
A: Differentially expressed genes in gastrointestinal stromal tumors (GIST) with liver metastasis tissues and normal gastric tissues (|log2FC| > 1; P < 0.05); B: Differentially expressed genes in imatinib sensitive and in seven Imatinib-resistant GIST patients (|log2FC| > 1; P < 0.05); C: Western blot assay of insulin-like growth factor 2 (IGF2) protein expression in GIST cell lines (GIST882, GIST882-R, GIST-T1, GIST-T1-R); D: ELISA of IGF2 expression in GIST cell lines (GIST882, GIST882-R, GIST-T1, GIST-T1-R).
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PMC11462673
Furthermore, analysis of the Cancer Cell Line Encyclopedia (CCLE) database revealed an overexpression of LDB1 in T-ALL cell lines compared to other cancer types (Fig. 1B).
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PMC6948907
The apoptotic effects of GE in combination with VPA were more significant that of each compound alone (Figure 6).
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PMC11659734
Therefore, a standardisation and pre‐validation of the advanced 3D liver spheroid model was performed by using multiple genotoxicity endpoints and by comparing the obtained results with standard genotoxicity models.
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PMC10713411
For the assessment of PRPCDGs risk signature's ability to predict outcomes for patients, the survival status, Kaplan-Meier survival curves, ROC curves as well as the heatmap of PRPCDGs’ expression were assessed.
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PMC11699465
Preparation of the pA-Tn5-adapter transposons involved three washes (1h for each) of the pA-Tn5 complex with Dig300 buffer.
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PMC11585254
Plasmids for pcDNA3 (empty vector), HA-CXCR5, FLAG-CXCR5, β-arrestin1-GFP, β-arrestin2-GFP, and pGloSensor-22F (pGLO) were previously described (Caballero et al., 2019; Zhuo et al., 2022; Zhuo et al., 2020).
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PMC9429973
According to the IPSS risk group classification 1(!%) resulted IPSS Low risk, 21 (20.4%) were IPSS Int-1 risk, 49 (47.6%) resulted IPSS Int-2 risk, and 32(31.1%) were IPSS High risk.
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