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OTAR3088
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BioData-CellLine_annotated

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PMC11755519
ZEB transcription factors may affect the repression of epithelial genes and transcription of mesenchymal genes.
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PMC11779605
After the injection, the animals were monitored and weighed daily and their tumors imaged twice per week.
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PMC6742971
The qualitative and quantitative analysis of functional avidity of individual T cell clonotypes has been important in understanding the cellular immune response in health and disease (25).
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PMC9895440
A Nikon CFI Apo TIRF NA 1.49 100x objective together with a 1.5x additional magnification unit was used with 1.515 NA oil mounted samples.
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PMC10093184
Their role in cancer is closely linked, but not limited, to tumor spread .
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PMC11754784
Fig. 2Implementation and molecular mechanism of three-layer two-input DNP.a Schematic figure of DNP1-based cellular recognition.
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PMC11402217
The Raw sequencing data analysis were performed as described previously Human-DKK1 plasmid was obtained from Hanyin company (Wuhan, CN).
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PMC11023271
We were intrigued by these findings, since they implied, during the wounding process, both the mechanical tearing and excessive availability of serum and growth factors may contribute to the down-regulation of RIPK4 in epidermis.
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PMC9844987
Although the remaining TFs contribute only marginally on their own to the predictions compared to TATA-box and high CpG content status (Figure 2D; Figure 2—figure supplement 3A), a baseline model (decision tree) based on CpG ratio and TBP binding site presence alone yielded worse performance than the full model (AUC = 0.71 vs 0.79 for the baseline model and the full model, respectively; Figure 2—figure supplement 2B).
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PMC11594588
Platelet activation is mediated by several agonists, namely collagen, thrombin, and ADP are involved in the regulation of hemostasis .
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PMC11719944
We presented a two-way dispersion graph along with its polytomous adjustment.
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PMC3888431
To overcome these limitations, genome and transcriptome sequencing is a valuable tool in modern research and biotechnology.
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PMC8414691
Scale bar = 5 μm.
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PMC9895440
n = 10.
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PMC11518702
GRB2-KO, however, decreased HGAL’s co-IP with SYK (in BCR-ligated cells, but not unstimulated cells) (8).
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PMC9878562
The data further support a mechanism of cell-to-cell-induced migration that is contact-independent.
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PMC11001582
This allows direct comparison with our polyGR mice but makes the polyPR model less physiological.
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PMC2614415
Genes with lower expression compared to normal tissue are shown in blue and yellow indicates genes that are overexpressed. (
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PMC11656657
p < 0.05, **p < 0.01, ****p-value = < 0.0001 In vitro anti-tumor activity of CAR.GD2 T-cells correlates to GD2 expression on human sarcoma cell lines. (
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PMC10968586
However, the underlying molecular mechanism ruling OLE activity differed between the two cell lines.
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PMC11676169
Further, for detecting endogenous interactions, CCRF-CEM cells were lysed in NETN lysis buffer.
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PMC11064533
Only ΔyggT was significantly (P < 0.05) more susceptible at the gentamicin concentration of 0.25 µg/mL. In order to add another omics layer, a global proteomics analysis of the wild-type strain was carried out for adhered and planktonic bacteria.
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PMC11754094
P = 0.0191 for large deletion between ART558-treated and non-treated HeLa cell line.
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PMC11300085
Therefore, we speculated that the inactivation of CMKLR1/RhoA/ROCK1-mediated EMT might be the potential reason for the difference in cell movement in OVCAR-3 cells.
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PMC6102174
Swertiakoulactone showed moderate activities inhibiting the HBsAg secretion (IC50 = 1.10 mM, SI = 4.4) and HBV DNA replication (IC50 = 1.16 mM, SI = 4.1) .
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PMC11055510
RT-qPCR analyzed the effect of miR-135a-3p interaction with IL1RAP on IL1RAP expression in SKOV3 cells. (
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PMC11144382
Furthermore, CRABP2 expression was significantly increased in the MSS human fibroblasts that had the c.819-592_1079-808del, Del3 (2-fold (P <0 .01) at the RNA level and 6.6-fold (P <0.0001) at the protein level), and c.1037_1038insT (3.3-fold (P <0 .0001) at the RNA level and 5.6-fold (P <0 .0001) at the protein level), when compared with the mean of the unrelated control human fibroblasts (Figures 2B and 3B and D).
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PMC11026382
Second, there was a proportion of DHFR mutations predicted to have negative epistasis to TYMS R166Q but observed to exhibit mild positive epistasis (Fig. 5e).
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PMC11549062
In a community‐based investigation of patients with asymptomatic severe carotid stenosis who did not receive surgeries, the estimated rate of ipsilateral carotid‐related acute ischemic stroke was 4.7% over 5 years .
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PMC11467964
In our study, the expression levels are markedly different and the expression levels in low‐risk group are higher.
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PMC11588085
Cancer cells that lose XIST expression become less differentiated and more plastic, allowing them to adapt more easily to their environment, which may contribute to cancer progression.
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PMC11757230
Fig. 4 Establishment of firefly luciferase (fLuc)-expressing canine lymphoma cell line. (
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PMC8839885
Statistical analysis: Statistical analysis was performed by Student’s t-test, with significant values at * p < 0.1, ** p < 0.01 and *** p < 0.001.
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PMC10198699
This interpretation is supported by judgments in jurisdictions that share the same principles as found in Roman-Dutch law.
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PMC11790599
Moreover, oncogenic RAS, its aberrant expression and activation, also contributes to hyperactive macropinocytosis and diverse cellular outcomes.
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PMC11522251
According to pharmacokinetics, the maximum in vivo plasma concentration Cmax Mean (SD) = 306 (63) μg/ml when cetuximab administration occurred at a dose of 500 mg/m every 14 days .
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PMC8414691
To prepare dsRNA, individual gene sequences were amplified by PCR from genomic DNA obtained from first-instar larvae of a wild type D. melanogaster strain.
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PMC11345828
The Mcl-1 inhibitors described in this manuscript were prepared following the representative synthetic routes in Schemes 1–3.
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PMC6102174
The bioassay in vitro suggested the ethanol extraction showed anti-HBV activity inhibiting HBsAg and HBeAg secretions with IC50 values of 462.4 (SI = 1.3) and 42.8 (SI = 14.1) mg/mL, and HBV DNA replication with an IC50 value of 29.0 (SI = 20.8) mg/mL. Bioassay-guided separation gave rise to the active Frs.
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PMC8873393
Before acquisition on the flow cytometer cell scanner, cells were filtered through a 0.45 μm mesh.
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PMC10506676
Then, these plasmids were extracted, and their quality and concentrations were determined using gel electrophoresis and spectrophotometry.
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PMC10055960
Compound 5 shows promising cytotoxicity against highly proliferative human ovarian tumor cell lines in vitro, having a comparable to, or greater, activity in comparison to the tested platinum-based drugs, with similar efficacy observed across all tested cell lines.
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PMC9024365
The stratification of SD4 puncta co-localized with GluA1 results in a significant increase in the mean cluster size of SD4 puncta co-localized with GluA1 compared with SD4 alone (Figure 6B).
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PMC10291556
Several Pt(II) or Pt(IV) complexes combining a Pt moiety with some NSAIDs (aspirin, indomethacin, ibuprofen, etc.)
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PMC11615743
The purification process was conducted via high‐performance liquid chromatography (HPLC) (Model 1620, Agilent Co.).
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PMC11106977
These isoforms have 13.5, 9.5, and 2.5 (orange) TPRs, respectively.
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PMC11585587
Then, we further used Western blot to detect the expression of mitochondrial pathway-related proteins.
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PMC6617630
Moreover, BETi suppressed MYC transcription and decreased BRD4 binding to MYC promoter in DHL cells.
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PMC5916734
The purified FIX solution was concentrated by ultrafiltration using a VivaFlow200 cassette with a 10 kDa PES membrane (Sartorius Stedim, Germany) and transferred into a storage solution containing 8 mM L-histidine, 0.8% sucrose, 208 mM glycine, pH 7.2, and 0.004% Tween 80.
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PMC8345486
Increased expression levels of pSer15-p53 and pSer37-p53 were noted in all cell lines except for OVCAR-3 cells in response to cisplatin (Figure S5B, Supplementary Materials).
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PMC10674574
The pharmaceutical industry guidelines specify the model drugs that may be used during the validation of the Caco-2 cell line.
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PMC9429973
Samples are manufactured from cell line material and one sample per annum is issued for participating laboratories to evaluate using their in-house methodology.
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PMC11098378
These data suggest that a common phosphatase activity encoded by effectors from S. enterica and S. flexneri can break arbovirus restriction in LD652 cells.
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PMC9024365
Representative confocal images of dendritic stretches from primary rat hippocampal neurons at DIV13.
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PMC5833712
Fig. 1Estrogen receptor subtype expression and response to ligands.a Representative RT-PCR and Western blot analyses of ESR1 and ESR2 expression in SKOV3 and A2780cis cells.
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PMC6267596
DIAP cell populations in both cell lines enrich for negative regulation of apoptosis (GO:0043066, P = 0.044822605, Count = 8, Red color), (GO:0043066, P = 0.06170948, Count = 14, Red color) and positive regulation for cell proliferation (GO:0008288, P = 0.004776948, Count = 9, Green color), (GO:0051301, P = 0.09358616, Count = 11, Green color), respectively, for U2932 and VAL DLBCL cells (Figure 4d and Figure 4i).
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PMC11594074
If comparing the hydrogen-bond-forming amino acids of DNMT1 with SAH in the used crystallographic structure (Table 3), the docking simulation results reveal that Glu1168 stands out as a common interacting residue.
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PMC10604092
Thus, the reduced food intake in our SLC-transplanted rats, observed despite reduced blood leptin levels, suggests that this dysfunction is possibly because of TNF-α and IL-1.
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PMC10761218
It provides antagonist drug potency by demonstrating the amount of drug required to block 50% of the biological process .
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PMC11536589
Scale bar: 100 μm.
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PMC11658074
Histological staining revealed that the fat graft group exhibited epidermal thinning, dermal thickening, increased collagen production, and reduced cellular senescence, which was consistent with the results from the inguinal skin model (Figs. 1h, S7).
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PMC4839679
Cells were fixed in situ by incubation with 50 μL of trichloroacetic acid at 4°C for 1 hour.
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PMC11796104
It has been demonstrated that circRNAs are closely related with osteoporosis through their effects as miRNA sponges by targeting major genes and signaling pathways related to osteoblast and osteoclast differentiation .
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PMC10507284
The growth curves of SW982 cells in NC and TROAP‐siRNA groups were examined by CCK‐8 assays (n = 3 for each group).
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PMC9532503
Anti-CD20 mAbs cause cell death through different pathways such as complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), and apoptosis .
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PMC10604092
In contrast, the expression levels of muscle-specific ubiquitin ligases in the gastrocnemius muscles of the force-fed SLC-transplanted rats increased significantly over time (Figure 6E–G).
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PMC10335954
Apoptotic cells were subsequently analyzed via flow cytometry, using MoFlo XDP (Beckman Coulter, Inc.).
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PMC11706297
In general, the halogen substitution increased the anticancer activity related to kinase inhibition as shown in compounds I–IV [28–32] (Figure 1).
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PMC9429973
equally contributing authors.
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PMC11742047
The amount of fluorescence generated was proportional to the caspase-3/7 cleavage activity in the sample.
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PMC8922418
Compared with the corresponding ABE or CBE, the base-editing efficiency of DBE is higher, and the off-target rate is lower.
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PMC11769522
The present study investigated the effects of Th2- or Th1-type cytokines on the production of keratinocyte-derived inflammatory mediators.
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PMC9429973
The median survival of patients who achieved CCyR during treatment with imatinib at a dose of 400 mg daily was 218 months (95% CI, 204-232) while in those who did not achieve was 152 months (95% CI, 120-185) (p = 0.001).
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PMC11770199
This limitation may contribute to their inefficiency in treating solid tumors, given the restricted intratumoral infiltration and immunosuppressive tumor microenvironment.
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PMC11335267
In marked contrast, the expression of Pomc mRNA was lower in Alx3-deficient mice than in control animals fed ad libitum, and did not respond with the expected decrease upon fasting (Fig. 8A).
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PMC10890055
We have previously shown that the cancerous osteoblast-like cell line U-2 OS is less sensitive than the L929 cell line to zinc ions .
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PMC9429973
Informed consent was obtained.
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PMC11659734
The EU‐FORA programme gave also the opportunity to the fellow to maximise the acquisition of scientific knowledge on genotoxicity risk assessment at the hosting institute ISS, through exchanges and discussion with the supervisor and researchers dealing with different aspects of the risk assessment.
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PMC10898159
BBIs can reverse the transcription abnormalities of KIT gene which are induced by BRD4.
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PMC10654497
Kaplan–Meier OS curve and ROC curve of the (C) training and (D) verification sets. (
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PMC11092382
In the future, toxicological research on sophocarpine must continue to occur to ensure its safety and efficacy in clinical applications.
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PMC11747949
Interestingly, we observed two tumor cell populations having different expressions of CD44 (Figure 3D, CD44 and CD44).
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PMC10213199
The RPN gene family comprises a non-ATPase proteasome regulatory complex that encodes a component of the 26 S proteasome and degrades polyubiquitinated proteins in the cytoplasm and nucleus .
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PMC9878278
WT and MDA5 knockout A549 were infected with ZIKV (MOI 1) and virus titers in the supernatants were determined by plaque assay at 48 hpi. (
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PMC8170755
Cytotoxicity of VPA against A549 Cells The cells were exposed to different concentrations (0-16 mM) of AVP for either 24, 48 or 72 h. The MTT results showed that VPA inhibited the growth of A549 cells in a concentration- and time-dependent manner (Figure 1).
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PMC11798926
Input (15 μL) and IP (50 μL) protein samples were heated to 70°C for 10 min and separated via gel electrophoresis on a Bio-Rad minigel system using 4–20% gradient gels (Bio-Rad Cat# 456–1,094).
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PMC11267830
Cells (300,000 per well) were plated into 6-well culture plates and exposed to Indisulam for 48 h. Cells were then harvested by centrifugation at 800 rpm for 4 min at 4 °C, then fixed in 75% ethanol overnight.
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PMC10125312
Zhao et al. determined that the noncancerous cell line HK-2 is more resistant than the 786-0 cancer kidney cell line to spherical AuNPs of different sizes at increasing concentration, as the autophagy mechanism employed to incorporate the nanoparticles seemed to protect them from harm, and their results agree with our findings that the cancer 786-0 cell line is more susceptible to high concentrations of AuNRs than normal cells.
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PMC11769516
DON affects the secretion of neurotransmitters in the brain in vivo, such as 5-hydroxytryptamine (5-HT, serotonin), which causes vomiting in pigs .
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PMC9014716
The ratio of EdU-positive to Hoechst 33342-positive Bel-7404 or HepG2 cells in the combined treatment group was significantly lower than that in the OXA group (Figure 1E–H).
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PMC11528603
Each value represents mean ± SD of three independent experiments.
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PMC10729469
Treatment of APP/PS1 mice with TCRAβ-Tregs showed significant increase (p < 0.05) in glucose uptake compared to APP/PS1 mice that were untreated or treated with polyclonal Tregs or EV-Tregs.
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PMC9429973
Regarding adverse events of special interest, CRS occurred in 8 pts (30%; all G1/2) and ICANS occurred in 1 pt (G2; discontinued epcoritamab, pt with prior CAR T).
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PMC9352806
Meanwhile, we detected the phosphorylation level of energy sensor AMPK and the expression level of autophagy marker LC3B (Fig. 5B).
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PMC9429973
qRT-PCR has been used to evaluate DIS3 silencing efficiency.
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PMC10932641
GPRC5D-AS1 is an RNA gene, belonging to lncRNA class, and a recent study has found that GPRC5D-AS1 can be used as a biomarker in clinical applications and the prognosis of lung squamous cell carcinoma (10).
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PMC11615101
Therefore, α-Taxilin can be targeted for its diagnostic and therapeutic potential in RA along with other parameters.
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PMC11665555
Afterward, all the differentially expressed genes (Supplemental Table 5) and all the differentially enriched metabolites of 5637GR and 5637P (Supplemental Table 2) were integrated in a joint-pathway multi-omic analysis.
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PMC11342785
Assays were performed at a protein concentration of 20 μM with 20 mM Hepes, 50 mM KCl, 3 mM DTT, and 12% dextran.
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PMC9684669
A Bar graph showing the synergistic effects of terfenadine (Ter) and doxorubicin (Dox) on MDR ovarian cancer cells.
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