OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11788920	Figure 1E and F show these studies in which the number of viable cells in multi-well plates is quantified in the absence of CRISPR–dCas9 treatment and after being treated with RNP1, RNP2, RNP3, RNP1 + RNP2 (′RNP1 + 2′ in figures), or RNP2 + RNP3 (′RNP2 + 3′ in figures).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1E", "and", "F", "show", "these", "studies", "in", "which", "the", "number", "of", "viable", "cells", "in", "multi-well", "plates", "is", "quantified", "in", "the", "absence", "of", "CRISPR", "–", "dCas9", "treatment", "and", "after", "being", "treated", "with", "RNP1", ",", "RNP2", ",", "RNP3", ",", "RNP1", "+", "RNP2", "(", "′RNP1", "+", "2′", "in", "figures", ")", ",", "or", "RNP2", "+", "RNP3", "(", "′RNP2", "+", "3′", "in", "figures", ")", "." ] } ]
PMC10329237	Furthermore, other proteins are also up-regulated during the EMT process including zinc finger transcriptional factors such as Snail1 and Slug (36).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "other", "proteins", "are", "also", "up-regulated", "during", "the", "EMT", "process", "including", "zinc", "finger", "transcriptional", "factors", "such", "as", "Snail1", "and", "Slug", "(", "36", ")", "." ] } ]
PMC9429973	Following combination therapy, we found a significant reduction in Calr-mutant donor chimerism, specifically in LT-HSCs and platelets, accompanied by reductions in LT-HSC frequency and platelet count.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "combination", "therapy", ",", "we", "found", "a", "significant", "reduction", "in", "Calr-mutant", "donor", "chimerism", ",", "specifically", "in", "LT-HSCs", "and", "platelets", ",", "accompanied", "by", "reductions", "in", "LT-HSC", "frequency", "and", "platelet", "count", "." ] } ]
PMC11757230	Some studies have reported differing effects of human MSCs on tumor cell growth in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "studies", "have", "reported", "differing", "effects", "of", "human", "MSCs", "on", "tumor", "cell", "growth", "in", "vitro", "and", "in", "vivo", "." ] } ]
PMC11786767	D: Confocal images of chromosomes and microtubules at prometaphase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ":", "Confocal", "images", "of", "chromosomes", "and", "microtubules", "at", "prometaphase", "." ] } ]
PMC9429973	Main secondary EPs were overall response rate (ORR) and progression-free survival (PFS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Main", "secondary", "EPs", "were", "overall", "response", "rate", "(", "ORR", ")", "and", "progression-free", "survival", "(", "PFS", ")", "." ] } ]
PMC10747160	While this initially perplexed researchers, it has now been widely accepted that cell surface attachment receptors are capable of binding to the SARS-CoV-2 virion and facilitating efficient viral infection of cells that have poor hACE2 expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "this", "initially", "perplexed", "researchers", ",", "it", "has", "now", "been", "widely", "accepted", "that", "cell", "surface", "attachment", "receptors", "are", "capable", "of", "binding", "to", "the", "SARS-CoV-2", "virion", "and", "facilitating", "efficient", "viral", "infection", "of", "cells", "that", "have", "poor", "hACE2", "expression", "." ] } ]
PMC11795610	In brief, the differentiated keratinocytes were fixed with 4% paraformaldehyde for 15 min and then permeabilized with 0.5% triton X-100 for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "the", "differentiated", "keratinocytes", "were", "fixed", "with", "4", "%", "paraformaldehyde", "for", "15", "min", "and", "then", "permeabilized", "with", "0.5", "%", "triton", "X-100", "for", "10", "min", "." ] } ]
PMC9429973	53% of patients with more than 5% BMB did not achieve a CR compared to 18% with less than 5% BMB. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "53", "%", "of", "patients", "with", "more", "than", "5", "%", "BMB", "did", "not", "achieve", "a", "CR", "compared", "to", "18", "%", "with", "less", "than", "5", "%", "BMB", ".", "(" ] } ]
PMC7171147	For drug treatments, cancer cells were serum starved and plated on COL11A1 extract for 48 h in media containing 1% FBS and treated with drugs (dasatinib, LY294002, MK2206 and dorsomorphin) for another 48 h. For cisplatin treatment, cancer cells were serum starved and cultured on uncoated plates, COL11A1-positive extract or COL11A1-negative extract in media containing 1% FBS for 24 h and treated with cisplatin for another 72 h. Cell viability was measured by CellTiter-Glo luminescent cell viability assay (Promega # G7572) using a Glomax Explorer Microplate Reader (Promega), according to the manufacturer’s protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "drug", "treatments", ",", "cancer", "cells", "were", "serum", "starved", "and", "plated", "on", "COL11A1", "extract", "for", "48", "h", "in", "media", "containing", "1", "%", "FBS", "and", "treated", "with", "drugs", "(", "dasatinib", ",", "LY294002", ",", "MK2206", "and", "dorsomorphin", ")", "for", "another", "48", "h.", "For", "cisplatin", "treatment", ",", "cancer", "cells", "were", "serum", "starved", "and", "cultured", "on", "uncoated", "plates", ",", "COL11A1-positive", "extract", "or", "COL11A1-negative", "extract", "in", "media", "containing", "1", "%", "FBS", "for", "24", "h", "and", "treated", "with", "cisplatin", "for", "another", "72", "h.", "Cell", "viability", "was", "measured", "by", "CellTiter-Glo", "luminescent", "cell", "viability", "assay", "(", "Promega", "#", "G7572", ")", "using", "a", "Glomax", "Explorer", "Microplate", "Reader", "(", "Promega", ")", ",", "according", "to", "the", "manufacturer", "’s", "protocols", "." ] } ]
PMC11775197	It has been proposed that the PPARβ/δ agonist GW501516 may contribute to the development of colitis-associated colon carcinogenesis, potentially through the increased expression of Glu1h and SLC1A5 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "proposed", "that", "the", "PPARβ/δ", "agonist", "GW501516", "may", "contribute", "to", "the", "development", "of", "colitis-associated", "colon", "carcinogenesis", ",", "potentially", "through", "the", "increased", "expression", "of", "Glu1h", "and", "SLC1A5", "." ] } ]
PMC11306331	Statistical test: Mann–Whitney U test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "test", ":", "Mann", "–", "Whitney", "U", "test", "." ] } ]
PMC8735881	In brief, the viruses were produced by transfecting HEK293T cells (6 × 10 cells in a P-100 mm dish) with 24 μg of plasmid encoding the molecular clone using a linear PEI transfection reagent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "the", "viruses", "were", "produced", "by", "transfecting", "HEK293", "T", "cells", "(", "6", "×", "10", "cells", "in", "a", "P-100", "mm", "dish", ")", "with", "24", "μg", "of", "plasmid", "encoding", "the", "molecular", "clone", "using", "a", "linear", "PEI", "transfection", "reagent", "." ] } ]
PMC10222971	Nowadays, many drugs based on natural products that contain a 1,4-naphthoquinone backbone in their chemical structure are used as anticancer agents, such as doxorubicin, daunorubicin, mitoxantrone and aclacinomycin A (Figure 1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nowadays", ",", "many", "drugs", "based", "on", "natural", "products", "that", "contain", "a", "1,4-naphthoquinone", "backbone", "in", "their", "chemical", "structure", "are", "used", "as", "anticancer", "agents", ",", "such", "as", "doxorubicin", ",", "daunorubicin", ",", "mitoxantrone", "and", "aclacinomycin", "A", "(", "Figure", "1", ")", "." ] } ]
PMC8978939	At normal oxygen level, HIF-α is hydroxylated at proline residues, in this form is recognized by pVHL, leading to rapid ubiquitination and degradation by the proteasome (11, 12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "normal", "oxygen", "level", ",", "HIF-α", "is", "hydroxylated", "at", "proline", "residues", ",", "in", "this", "form", "is", "recognized", "by", "pVHL", ",", "leading", "to", "rapid", "ubiquitination", "and", "degradation", "by", "the", "proteasome", "(", "11", ",", "12", ")", "." ] } ]
PMC9429973	A. Al Raizah, M. Alzahrani, A. Hejazi, M. Almegren, T. Alshuaibi, A. Alaskar Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A.", "Al", "Raizah", ",", "M.", "Alzahrani", ",", "A.", "Hejazi", ",", "M.", "Almegren", ",", "T.", "Alshuaibi", ",", "A.", "Alaskar", "Oncology", ",", "King", "Abdulaziz", "Medical", "City", ",", "Ministry", "of", "National", "Guard", "Health", "Affairs", "." ] } ]
PMC5839394	The extracted DNA was suspended in 1 ml milliQ and transferred in cuvette for fluorescence analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extracted", "DNA", "was", "suspended", "in", "1", "ml", "milliQ", "and", "transferred", "in", "cuvette", "for", "fluorescence", "analyses", "." ] } ]
PMC5839394	Flow cytometry analysis of DNA distribution in propidium iodide-stained cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "analysis", "of", "DNA", "distribution", "in", "propidium", "iodide-stained", "cells", ".", "(" ] } ]
PMC7039683	Some exceptions to the general pattern were observed (e.g., hspb9 and npm1b, Figure 1H); this might reflect the fact that enhancers do not always regulate an adjacent gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "exceptions", "to", "the", "general", "pattern", "were", "observed", "(", "e.g.", ",", "hspb9", "and", "npm1b", ",", "Figure", "1H", ")", ";", "this", "might", "reflect", "the", "fact", "that", "enhancers", "do", "not", "always", "regulate", "an", "adjacent", "gene", "." ] } ]
PMC10547921	NIR-PIT drugs can form a new targeted anti-cancer platform with devices that irradiate infrared light to tumor sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NIR-PIT", "drugs", "can", "form", "a", "new", "targeted", "anti-cancer", "platform", "with", "devices", "that", "irradiate", "infrared", "light", "to", "tumor", "sites", "." ] } ]
PMC11618052	In a recent publication from our lab, we describe the discovery of a novel class of 1,2,3-triazole/quinoline hybrids as antiproliferative compounds that act as multi-targeted inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "recent", "publication", "from", "our", "lab", ",", "we", "describe", "the", "discovery", "of", "a", "novel", "class", "of", "1,2,3-triazole/quinoline", "hybrids", "as", "antiproliferative", "compounds", "that", "act", "as", "multi-targeted", "inhibitors", "." ] } ]
PMC11661024	On the contrary, postbiotics can offer anti-inflammatory effects similar to probiotic bacteria, higher shelf life, and sustainability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "contrary", ",", "postbiotics", "can", "offer", "anti-inflammatory", "effects", "similar", "to", "probiotic", "bacteria", ",", "higher", "shelf", "life", ",", "and", "sustainability", "." ] } ]
PMC10898159	Fibroblast growth factors (FGFs) and their receptors (FGFR1-4) are universally expressed in human tissues and have an important effect on various cell physiologic processes ranging from cell proliferation, survival, and migration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fibroblast", "growth", "factors", "(", "FGFs", ")", "and", "their", "receptors", "(", "FGFR1", "-", "4", ")", "are", "universally", "expressed", "in", "human", "tissues", "and", "have", "an", "important", "effect", "on", "various", "cell", "physiologic", "processes", "ranging", "from", "cell", "proliferation", ",", "survival", ",", "and", "migration", "." ] } ]
PMC11271800	However, the combination of the two in a mouse model inhibited tumor progression and suppressed M1 to M2 polarization, which in turn reduced M2 TAM infiltration in GIST, thereby inhibiting tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "combination", "of", "the", "two", "in", "a", "mouse", "model", "inhibited", "tumor", "progression", "and", "suppressed", "M1", "to", "M2", "polarization", ",", "which", "in", "turn", "reduced", "M2", "TAM", "infiltration", "in", "GIST", ",", "thereby", "inhibiting", "tumor", "progression", "." ] } ]
PMC11711127	The inhibition of T cell proliferation by anti-PD-L1 Abs is primarily due to increased IFN-γ production, with a subsequent rise in NO production by macrophages (164).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inhibition", "of", "T", "cell", "proliferation", "by", "anti-PD-L1", "Abs", "is", "primarily", "due", "to", "increased", "IFN-γ", "production", ",", "with", "a", "subsequent", "rise", "in", "NO", "production", "by", "macrophages", "(", "164", ")", "." ] } ]
PMC9429973	Forty-seven (68%) patients had an identifiable provoking factor apart from MBL/CLL including second active malignancy (n=21), surgery (n=9), recent hospitalization (n=6), travel (n=4), trauma (n=3), line-associated VTE (n=3), and immobility (n=1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Forty-seven", "(", "68", "%", ")", "patients", "had", "an", "identifiable", "provoking", "factor", "apart", "from", "MBL/CLL", "including", "second", "active", "malignancy", "(", "n=21", ")", ",", "surgery", "(", "n=9", ")", ",", "recent", "hospitalization", "(", "n=6", ")", ",", "travel", "(", "n=4", ")", ",", "trauma", "(", "n=3", ")", ",", "line-associated", "VTE", "(", "n=3", ")", ",", "and", "immobility", "(", "n=1", ")", "." ] } ]
PMC3675084	Pan β-tubulin and β-actin were loading controls. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pan", "β-tubulin", "and", "β-actin", "were", "loading", "controls", ".", "(" ] } ]
PMC11190538	Formulation of C-PC nanophytosomes was Patent registered under the No: EG/P/2022/1221.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Formulation", "of", "C-PC", "nanophytosomes", "was", "Patent", "registered", "under", "the", "No", ":", "EG/P/2022/1221", "." ] } ]
PMC11743316	Mitophagy plays a dual role in cancer and may either promote or suppress tumorigenesis, depending on the tumor type and molecular context .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitophagy", "plays", "a", "dual", "role", "in", "cancer", "and", "may", "either", "promote", "or", "suppress", "tumorigenesis", ",", "depending", "on", "the", "tumor", "type", "and", "molecular", "context", "." ] } ]
PMC11641630	Additionally, related to non-tuberculous mycobacteria, heat-killed Mycobacterium indicus pranii has been shown to inhibit melanoma cell invasion by reducing MMP-9 expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "related", "to", "non-tuberculous", "mycobacteria", ",", "heat-killed", "Mycobacterium", "indicus", "pranii", "has", "been", "shown", "to", "inhibit", "melanoma", "cell", "invasion", "by", "reducing", "MMP-9", "expression", "." ] } ]
PMC8973085	The NMR spectra were preserved on a Varian Mercury VX-400 NMR spectrometer (Varian, Palo Alto, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NMR", "spectra", "were", "preserved", "on", "a", "Varian", "Mercury", "VX-400", "NMR", "spectrometer", "(", "Varian", ",", "Palo", "Alto", ",", "CA", ")", "." ] } ]
PMC9429973	Methods: 915 AML patients (498 < 65 years, 417 ≥ 65 years) treated at the University Hospital of Düsseldorf were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "915", "AML", "patients", "(", "498", "<", "65", "years", ",", "417", "≥", "65", "years", ")", "treated", "at", "the", "University", "Hospital", "of", "Düsseldorf", "were", "analyzed", "." ] } ]
PMC11297139	The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "representative", "images", "supported", "by", "the", "relevant", "statistics", "have", "been", "chosen", "upon", "three", "independent", "preparations", "with", "similar", "outcomes", "." ] } ]
PMC11594588	In all analyzed organisms (bacteria and mammals), etheno DNA adducts induce different types of mutations such as base substitutions, frameshift mutations, and sister chromatid exchanges and chromosomal aberrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "analyzed", "organisms", "(", "bacteria", "and", "mammals", ")", ",", "etheno", "DNA", "adducts", "induce", "different", "types", "of", "mutations", "such", "as", "base", "substitutions", ",", "frameshift", "mutations", ",", "and", "sister", "chromatid", "exchanges", "and", "chromosomal", "aberrations", "." ] } ]
PMC11705484	CMP9 showed a good safety profile, while CMP1 increased serum Urea and Crea levels, indicating kidney toxicity exerted by CMP1 (Figure 4I,J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CMP9", "showed", "a", "good", "safety", "profile", ",", "while", "CMP1", "increased", "serum", "Urea", "and", "Crea", "levels", ",", "indicating", "kidney", "toxicity", "exerted", "by", "CMP1", "(", "Figure", "4I", ",", "J", ")", "." ] } ]
PMC10212663	To verify whether the application of RANKL inhibitor has clinical benefit, 57 patients diagnosed as LUAD with bone metastases who have received chemotherapy (±targeted agents but not immunotherapy as stated beforehand) as well as concomitant RANKL inhibitor (denosumab) or phosphates were identified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "verify", "whether", "the", "application", "of", "RANKL", "inhibitor", "has", "clinical", "benefit", ",", "57", "patients", "diagnosed", "as", "LUAD", "with", "bone", "metastases", "who", "have", "received", "chemotherapy", "(", "±targeted", "agents", "but", "not", "immunotherapy", "as", "stated", "beforehand", ")", "as", "well", "as", "concomitant", "RANKL", "inhibitor", "(", "denosumab", ")", "or", "phosphates", "were", "identified", "." ] } ]
PMC9119314	Furthermore, these compounds can be interrogated for gametocidal activity by exploring their activity against the male and female gametes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "these", "compounds", "can", "be", "interrogated", "for", "gametocidal", "activity", "by", "exploring", "their", "activity", "against", "the", "male", "and", "female", "gametes", "." ] } ]
PMC11628309	These models closely replicate key features involved in PD pathology such as mitochondrial dysfunction, protein aggregation and ROS accumulation (Ke et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "models", "closely", "replicate", "key", "features", "involved", "in", "PD", "pathology", "such", "as", "mitochondrial", "dysfunction", ",", "protein", "aggregation", "and", "ROS", "accumulation", "(", "Ke", "et", "al.", ",", "2021", ")", "." ] } ]
PMC11741906	These studies focused on molecular drivers of chemoresistance and aimed to suggest miRNAs with prognostic potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "studies", "focused", "on", "molecular", "drivers", "of", "chemoresistance", "and", "aimed", "to", "suggest", "miRNAs", "with", "prognostic", "potential", "." ] } ]
PMC11638255	Of note, neutrophils have been demonstrated to mediate ADCC against neuroblastoma in the presence of anti-GD2 antibody, illuminating a possible link to the enhanced tumor clearance conferred by immunocombination therapy in the Th-MYCN model (Fig. 1b,c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "neutrophils", "have", "been", "demonstrated", "to", "mediate", "ADCC", "against", "neuroblastoma", "in", "the", "presence", "of", "anti-GD2", "antibody", ",", "illuminating", "a", "possible", "link", "to", "the", "enhanced", "tumor", "clearance", "conferred", "by", "immunocombination", "therapy", "in", "the", "Th-MYCN", "model", "(", "Fig.", "1b", ",", "c", ")", "." ] } ]
PMC9429973	Data was analyzed by SPSS version 23.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "was", "analyzed", "by", "SPSS", "version", "23.0", "." ] } ]
PMC8973085	calcd for C29H22FN3O2S: C, 70.29; H, 4.47; N, 8.48.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "calcd", "for", "C29H22FN3O2S", ":", "C", ",", "70.29", ";", "H", ",", "4.47", ";", "N", ",", "8.48", "." ] } ]
PMC11574271	Invasive growth of bladder cancer cells into the neighboring tissue is a critical event directly associated with tumor malignant progression, chemoresistance, and clinical outcome .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Invasive", "growth", "of", "bladder", "cancer", "cells", "into", "the", "neighboring", "tissue", "is", "a", "critical", "event", "directly", "associated", "with", "tumor", "malignant", "progression", ",", "chemoresistance", ",", "and", "clinical", "outcome", "." ] } ]
PMC10919056	Destruction of GJB1 plays a role in promoting the occurrence and development of ovarian cancer and is not conducive to the action of chemical drugs (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Destruction", "of", "GJB1", "plays", "a", "role", "in", "promoting", "the", "occurrence", "and", "development", "of", "ovarian", "cancer", "and", "is", "not", "conducive", "to", "the", "action", "of", "chemical", "drugs", "(", "34", ")", "." ] } ]
PMC11087301	Polyploid giant cancer cells (PGCCs) are a subgroup of dormant tumor tissue cells which exhibit CSC features and facilitate tumor recurrence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Polyploid", "giant", "cancer", "cells", "(", "PGCCs", ")", "are", "a", "subgroup", "of", "dormant", "tumor", "tissue", "cells", "which", "exhibit", "CSC", "features", "and", "facilitate", "tumor", "recurrence", "." ] } ]
PMC9429973	Through genome-wide loss-of-function screens using CRISPR/Cas9 we identified that the transcriptional co-regulator strawberry notch homolog 2 (SBNO2) is an essential direct transcriptional target of STAT3 in transformed mHSPC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "genome-wide", "loss-of-function", "screens", "using", "CRISPR/Cas9", "we", "identified", "that", "the", "transcriptional", "co-regulator", "strawberry", "notch", "homolog", "2", "(", "SBNO2", ")", "is", "an", "essential", "direct", "transcriptional", "target", "of", "STAT3", "in", "transformed", "mHSPC", "." ] } ]
PMC11564322	The data are expressed as means ± SD of three independent experiments and presented as a percent of the control Cell number.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "are", "expressed", "as", "means", "±", "SD", "of", "three", "independent", "experiments", "and", "presented", "as", "a", "percent", "of", "the", "control", "Cell", "number", "." ] } ]
PMC11755467	Indeed, no negative growth effect was seen for Enoxacin treatment, while nalidixic acid led to a significant loss of viability (IC50~75–115 µM), with a similar toxic effect seen for high amounts of DMSO (IC50~244–279 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "no", "negative", "growth", "effect", "was", "seen", "for", "Enoxacin", "treatment", ",", "while", "nalidixic", "acid", "led", "to", "a", "significant", "loss", "of", "viability", "(", "IC50~75–115", "µM", ")", ",", "with", "a", "similar", "toxic", "effect", "seen", "for", "high", "amounts", "of", "DMSO", "(", "IC50~244–279", "µM", ")", "." ] } ]
PMC11515150	Cytotoxicity of 12 C CAR-NK cells and NT-NK cells against CD5 hematologic malignant cells was evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "of", "12", "C", "CAR-NK", "cells", "and", "NT-NK", "cells", "against", "CD5", "hematologic", "malignant", "cells", "was", "evaluated", "." ] } ]
PMC11803918	Second, the hybrid exosomes have the capability to activate the immune system, promoting antitumor immune responses, which may help in the long-term control of cancer and reduce the risk of tumor recurrence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ",", "the", "hybrid", "exosomes", "have", "the", "capability", "to", "activate", "the", "immune", "system", ",", "promoting", "antitumor", "immune", "responses", ",", "which", "may", "help", "in", "the", "long-term", "control", "of", "cancer", "and", "reduce", "the", "risk", "of", "tumor", "recurrence", "." ] } ]
PMC7723249	Treatment with EGTA, a Ca chelator, after the treatment with PMA, leads to complete opening of intercellular junctions and disrupting of the polarization of treated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "EGTA", ",", "a", "Ca", "chelator", ",", "after", "the", "treatment", "with", "PMA", ",", "leads", "to", "complete", "opening", "of", "intercellular", "junctions", "and", "disrupting", "of", "the", "polarization", "of", "treated", "cells", "." ] } ]
PMC11683240	Values of median are given as x-fold of the untreated control (Con), mean ± SEM (n = 9 values from three independent experiments).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "of", "median", "are", "given", "as", "x-fold", "of", "the", "untreated", "control", "(", "Con", ")", ",", "mean", "±", "SEM", "(", "n", "=", "9", "values", "from", "three", "independent", "experiments", ")", "." ] } ]
PMC10936243	So, everybody is in charge of animal welfare at every stage and I think it’s not a matter of cost I would say, the cost is very minimal.” “	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", ",", "everybody", "is", "in", "charge", "of", "animal", "welfare", "at", "every", "stage", "and", "I", "think", "it", "’s", "not", "a", "matter", "of", "cost", "I", "would", "say", ",", "the", "cost", "is", "very", "minimal", ".", "”", "“" ] } ]
PMC10178190	We also demonstrated that the combination of a platinum drug with fisetin and other flavonoids restored platinum drug sensitivity to OC cells that were co-cultured with MSC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "demonstrated", "that", "the", "combination", "of", "a", "platinum", "drug", "with", "fisetin", "and", "other", "flavonoids", "restored", "platinum", "drug", "sensitivity", "to", "OC", "cells", "that", "were", "co-cultured", "with", "MSC", "." ] } ]
PMC10788478	In this pathway, β‐catenin is engaged by a complex comprising glycogen synthase kinase 3β (GSK‐3β), adenomatous polyposis coli (APC), and Axin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "pathway", ",", "β‐catenin", "is", "engaged", "by", "a", "complex", "comprising", "glycogen", "synthase", "kinase", "3β", "(", "GSK‐3β", ")", ",", "adenomatous", "polyposis", "coli", "(", "APC", ")", ",", "and", "Axin", "." ] } ]
PMC2614415	= p-value less than 0.0025 by students T-test.) (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "=", "p-value", "less", "than", "0.0025", "by", "students", "T-test", ".", ")", "(" ] } ]
PMC9429973	As such, they are often a challenge to diagnose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "such", ",", "they", "are", "often", "a", "challenge", "to", "diagnose", "." ] } ]
PMC2196094	Using this technique, five novel proteases, designated RMCP-3, -4, -8, -9, and -10 were isolated from the RBL-1 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Using", "this", "technique", ",", "five", "novel", "proteases", ",", "designated", "RMCP-3", ",", "-4", ",", "-8", ",", "-9", ",", "and", "-10", "were", "isolated", "from", "the", "RBL-1", "cell", "line", "." ] } ]
PMC5839394	Proteomic map of SKBR3 control cells.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Proteomic", "map", "of", "SKBR3", "control", "cells", "." ] } ]
PMC6442998	To assess the role of YAP pathway in GIST cells lines, we used verteporfin, an inhibitor of YAP/TEAD interaction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", "role", "of", "YAP", "pathway", "in", "GIST", "cells", "lines", ",", "we", "used", "verteporfin", ",", "an", "inhibitor", "of", "YAP/TEAD", "interaction", "." ] } ]
PMC8010066	The dried weight of alginate was measured as µg/mL. Antibiotic disks (MAST, UK) and E-tests (Liofilchem, Italy) were used to examine the strains` susceptibility to several antibiotics before and after their co-culture growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dried", "weight", "of", "alginate", "was", "measured", "as", "µg/mL.", "Antibiotic", "disks", "(", "MAST", ",", "UK", ")", "and", "E-tests", "(", "Liofilchem", ",", "Italy", ")", "were", "used", "to", "examine", "the", "strains", "`", "susceptibility", "to", "several", "antibiotics", "before", "and", "after", "their", "co-culture", "growth", "." ] } ]
PMC9429973	Median RUX duration was 4.0 months (IQR, 3.0–6.1) for refractory or intolerant patients and 11.7 months (IQR, 6.5–17.1) for those with PD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "RUX", "duration", "was", "4.0", "months", "(", "IQR", ",", "3.0–6.1", ")", "for", "refractory", "or", "intolerant", "patients", "and", "11.7", "months", "(", "IQR", ",", "6.5–17.1", ")", "for", "those", "with", "PD", "." ] } ]
PMC11459296	Infiltration of human NK cells and T cells also showed a significant correlation with reduced leukemia multiorgan engraftment in PB, BM, liver, and spleen (online supplemental figure S1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Infiltration", "of", "human", "NK", "cells", "and", "T", "cells", "also", "showed", "a", "significant", "correlation", "with", "reduced", "leukemia", "multiorgan", "engraftment", "in", "PB", ",", "BM", ",", "liver", ",", "and", "spleen", "(", "online", "supplemental", "figure", "S1E", ")", "." ] } ]
PMC11806106	Activation and deactivation of GPCRs are mostly measured in downstream signaling, indirect or amplified assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "and", "deactivation", "of", "GPCRs", "are", "mostly", "measured", "in", "downstream", "signaling", ",", "indirect", "or", "amplified", "assays", "." ] } ]
PMC4270159	PDGFRα.p-AKT S473.AKT.p-ERK T202/Y204.ERK.pFRS2α Y196.FRS2α.β-tubulin [additional control].A. Loading control.iii.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PDGFRα.p-AKT", "S473.AKT.p-ERK", "T202/Y204.ERK.pFRS2α", "Y196.FRS2α.β-tubulin", "[", "additional", "control].A.", "Loading", "control.iii", "." ] } ]
PMC11759543	BFTC 905 cell tumorsphere formation assay was simulated to mimic an in vitro tissue treatment experiment.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BFTC", "905", "cell", "tumorsphere", "formation", "assay", "was", "simulated", "to", "mimic", "an", "in", "vitro", "tissue", "treatment", "experiment", "." ] } ]
PMC10589262	Colocalization of membranous MT-KIT with EEA1 and LAMP1 was clearly observed 15 and 30 min after tracking, and disappeared after 1 h (Supplementary Fig. S3B, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colocalization", "of", "membranous", "MT-KIT", "with", "EEA1", "and", "LAMP1", "was", "clearly", "observed", "15", "and", "30", "min", "after", "tracking", ",", "and", "disappeared", "after", "1", "h", "(", "Supplementary", "Fig.", "S3B", ",", "C", ")", "." ] } ]
PMC11225860	After each division the cell becomes notably larger, and presents with disfigured cellular morphology at the end of G2, before each division failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "each", "division", "the", "cell", "becomes", "notably", "larger", ",", "and", "presents", "with", "disfigured", "cellular", "morphology", "at", "the", "end", "of", "G2", ",", "before", "each", "division", "failure", "." ] } ]
PMC11740573	Moreover, we assessed the anti-bacterial properties of calcitriol, as well as its synergistic activity with antibiotics that are used for the treatment of AV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "we", "assessed", "the", "anti-bacterial", "properties", "of", "calcitriol", ",", "as", "well", "as", "its", "synergistic", "activity", "with", "antibiotics", "that", "are", "used", "for", "the", "treatment", "of", "AV", "." ] } ]
PMC11412752	After a 0.5 h infection, the cells were washed with PBS and subsequently cultured for an additional 0.5 h in DMEM-FBS (10%) supplemented with 100 μg/mL gentamicin (A620217; Sangon Biotech) to remove extracellular bacteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "a", "0.5", "h", "infection", ",", "the", "cells", "were", "washed", "with", "PBS", "and", "subsequently", "cultured", "for", "an", "additional", "0.5", "h", "in", "DMEM-FBS", "(", "10", "%", ")", "supplemented", "with", "100", "μg/mL", "gentamicin", "(", "A620217", ";", "Sangon", "Biotech", ")", "to", "remove", "extracellular", "bacteria", "." ] } ]
PMC9429973	Although the incidence of breast cancer, and thereby the number of breast reconstructions, is on the rise, it is likely that the rapid increase in the number of BIA-ALCL cases since 2018 is due to increased awareness of this disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "incidence", "of", "breast", "cancer", ",", "and", "thereby", "the", "number", "of", "breast", "reconstructions", ",", "is", "on", "the", "rise", ",", "it", "is", "likely", "that", "the", "rapid", "increase", "in", "the", "number", "of", "BIA-ALCL", "cases", "since", "2018", "is", "due", "to", "increased", "awareness", "of", "this", "disease", "." ] } ]
PMC11534377	The variation in staining intensity reflects the relative quantity of cells that have migrated, with darker areas denoting higher densities of cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "variation", "in", "staining", "intensity", "reflects", "the", "relative", "quantity", "of", "cells", "that", "have", "migrated", ",", "with", "darker", "areas", "denoting", "higher", "densities", "of", "cells", "." ] } ]
PMC11411131	Then, transfected Cos-7 cells were treated with MeHg (0, or 6 µM) for 24 h. MeHg only reduced the HA signal while leaving the FLAG signal unchanged (Fig. 1C).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "transfected", "Cos-7", "cells", "were", "treated", "with", "MeHg", "(", "0", ",", "or", "6", "µM", ")", "for", "24", "h.", "MeHg", "only", "reduced", "the", "HA", "signal", "while", "leaving", "the", "FLAG", "signal", "unchanged", "(", "Fig.", "1C", ")", "." ] } ]
PMC9429973	Effectiveness: 144 (81.4%) pt achieved CR after Induction1or2, of them 76pt were consolidated with alloSCT, 24pt received maintenance and 41pt proceed to W&W. Median OS for the whole population was not reached and the 24months OS was 68%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effectiveness", ":", "144", "(", "81.4", "%", ")", "pt", "achieved", "CR", "after", "Induction1or2", ",", "of", "them", "76pt", "were", "consolidated", "with", "alloSCT", ",", "24pt", "received", "maintenance", "and", "41pt", "proceed", "to", "W&W.", "Median", "OS", "for", "the", "whole", "population", "was", "not", "reached", "and", "the", "24months", "OS", "was", "68", "%", "." ] } ]
PMC6892818	mCD40L triggered reactive oxygen species (ROS) production, critical in apoptosis, and NADPH oxidase (Nox)-subunit p40phox phosphorylation, with Nox blockade abrogating apoptosis thus implying Nox-dependent initial ROS release.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mCD40L", "triggered", "reactive", "oxygen", "species", "(", "ROS", ")", "production", ",", "critical", "in", "apoptosis", ",", "and", "NADPH", "oxidase", "(Nox)-subunit", "p40phox", "phosphorylation", ",", "with", "Nox", "blockade", "abrogating", "apoptosis", "thus", "implying", "Nox-dependent", "initial", "ROS", "release", "." ] } ]
PMC11704135	According to the findings of this study, compounds 12, and 6 showed higher scavenging activity than the start compound 1, as the modification made on these compounds, through ethyl and benzoyl substitution, had resulted in 127.56, and 51.10%, respectively, increases in the DPPH scavenging activity of these compounds as compared to the start compound (Table 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "findings", "of", "this", "study", ",", "compounds", "12", ",", "and", "6", "showed", "higher", "scavenging", "activity", "than", "the", "start", "compound", "1", ",", "as", "the", "modification", "made", "on", "these", "compounds", ",", "through", "ethyl", "and", "benzoyl", "substitution", ",", "had", "resulted", "in", "127.56", ",", "and", "51.10", "%", ",", "respectively", ",", "increases", "in", "the", "DPPH", "scavenging", "activity", "of", "these", "compounds", "as", "compared", "to", "the", "start", "compound", "(", "Table", "4", ")", "." ] } ]
PMC11025866	However, since NaB is an HDACi, expression of a very large number of genes is altered by NaB (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "since", "NaB", "is", "an", "HDACi", ",", "expression", "of", "a", "very", "large", "number", "of", "genes", "is", "altered", "by", "NaB", "(", "Table", "2", ")", "." ] } ]
PMC11799978	Depletion of FAP-expressing fibroblasts caused necrosis of tumor cells and CAFs in murine models of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Depletion", "of", "FAP-expressing", "fibroblasts", "caused", "necrosis", "of", "tumor", "cells", "and", "CAFs", "in", "murine", "models", "of", "cancer", "." ] } ]
PMC11322866	GSK126 and AG126 exhibited antagonistic effects mainly on RPMI-8226 and OCI-MY5 cells ( Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSK126", "and", "AG126", "exhibited", "antagonistic", "effects", "mainly", "on", "RPMI-8226", "and", "OCI-MY5", "cells", "(", "Figure", "4B", ")", "." ] } ]
PMC11521786	3LL-R3 cells were treated with immune sera (heat inactivated and 1:20 diluted).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3LL-R3", "cells", "were", "treated", "with", "immune", "sera", "(", "heat", "inactivated", "and", "1:20", "diluted", ")", "." ] } ]
PMC11686380	Polyclonal rabbit anti-Sept11 was prepared as described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Polyclonal", "rabbit", "anti-Sept11", "was", "prepared", "as", "described", "." ] } ]
PMC10154881	Thus, the ability to target only NECTIN4 is the advantage of rMV‐SLAMblind.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "ability", "to", "target", "only", "NECTIN4", "is", "the", "advantage", "of", "rMV‐SLAMblind", "." ] } ]
PMC11366496	Batch effect is a common problem in statistical analysis, especially in biological and medical research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Batch", "effect", "is", "a", "common", "problem", "in", "statistical", "analysis", ",", "especially", "in", "biological", "and", "medical", "research", "." ] } ]
PMC9429973	Data were collected from 29 centers across North America (United States and Canada) and the European Union.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "collected", "from", "29", "centers", "across", "North", "America", "(", "United", "States", "and", "Canada", ")", "and", "the", "European", "Union", "." ] } ]
PMC8041314	Expression of adenosine triphosphate-(ATP)-binding cassette (ABC) transporters in multidrug-resistant cancer remains a huge obstacle in cancer chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "adenosine", "triphosphate-(ATP)-binding", "cassette", "(", "ABC", ")", "transporters", "in", "multidrug-resistant", "cancer", "remains", "a", "huge", "obstacle", "in", "cancer", "chemotherapy", "." ] } ]
PMC11774251	The anti-psoriatic mechanism of Tan-I involves the dysfunction of keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anti-psoriatic", "mechanism", "of", "Tan-I", "involves", "the", "dysfunction", "of", "keratinocytes", "." ] } ]
PMC11632064	Treatment of MeWo cells with BI-D1870 reduced the expression of Dopachrome Tautomerase/TRP-2 (DCT), a modulator of the melanocytic state (Lenggenhager et al, 2014; Muccioli et al, 2023), while treatment with LJH685 had no impact (Fig 2K and L).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "of", "MeWo", "cells", "with", "BI-D1870", "reduced", "the", "expression", "of", "Dopachrome", "Tautomerase/TRP-2", "(", "DCT", ")", ",", "a", "modulator", "of", "the", "melanocytic", "state", "(", "Lenggenhager", "et", "al", ",", "2014", ";", "Muccioli", "et", "al", ",", "2023", ")", ",", "while", "treatment", "with", "LJH685", "had", "no", "impact", "(", "Fig", "2", "K", "and", "L", ")", "." ] } ]
PMC11568601	Considering the enrichment of the biological process “IRE1-mediated unfolded protein response”, it is reasonable to speculate that TGT may regulate the IRE1/CHOP pathway to trigger osteosarcoma cell apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Considering", "the", "enrichment", "of", "the", "biological", "process", "“", "IRE1-mediated", "unfolded", "protein", "response", "”", ",", "it", "is", "reasonable", "to", "speculate", "that", "TGT", "may", "regulate", "the", "IRE1/CHOP", "pathway", "to", "trigger", "osteosarcoma", "cell", "apoptosis", "." ] } ]
PMC9429973	The light chain was Lambda in 50% of cases, whereas it is predominant (80%) in the literature (1), and cardiac involvement was the leading cause of morbidity and mortality as similar as what is reported (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "light", "chain", "was", "Lambda", "in", "50", "%", "of", "cases", ",", "whereas", "it", "is", "predominant", "(", "80", "%", ")", "in", "the", "literature", "(", "1", ")", ",", "and", "cardiac", "involvement", "was", "the", "leading", "cause", "of", "morbidity", "and", "mortality", "as", "similar", "as", "what", "is", "reported", "(", "1", ")", "." ] } ]
PMC9964635	Element analysis: C, 65.41; H, 7.69; N, 15.27; S, 11.65% (Figures S3–S5 and S8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Element", "analysis", ":", "C", ",", "65.41", ";", "H", ",", "7.69", ";", "N", ",", "15.27", ";", "S", ",", "11.65", "%", "(", "Figures", "S3–S5", "and", "S8", ")", "." ] } ]
PMC5417661	The fluorescence per well was measured in a FLUOStar Optima (BMG Labtech GmbH) and a survival index % (SI) for each compound-treated well was calculated with the equation: Compound-treated cells minus blank divided by control cells minus blank.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescence", "per", "well", "was", "measured", "in", "a", "FLUOStar", "Optima", "(", "BMG", "Labtech", "GmbH", ")", "and", "a", "survival", "index", "%", "(", "SI", ")", "for", "each", "compound-treated", "well", "was", "calculated", "with", "the", "equation", ":", "Compound-treated", "cells", "minus", "blank", "divided", "by", "control", "cells", "minus", "blank", "." ] } ]
PMC11748335	Notably, the number of loops in the long LOCK regions was significantly higher than that in the randomly selected regions, both across the entire genome and within the common PMDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "the", "number", "of", "loops", "in", "the", "long", "LOCK", "regions", "was", "significantly", "higher", "than", "that", "in", "the", "randomly", "selected", "regions", ",", "both", "across", "the", "entire", "genome", "and", "within", "the", "common", "PMDs", "." ] } ]
PMC10212663	We then validated this finding using the RNA‐sequencing data and clinical data from the TCGA database both in the advanced (Figure 2(a)) and non‐advanced settings (Figure S2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "validated", "this", "finding", "using", "the", "RNA‐sequencing", "data", "and", "clinical", "data", "from", "the", "TCGA", "database", "both", "in", "the", "advanced", "(", "Figure", "2(a", ")", ")", "and", "non‐advanced", "settings", "(", "Figure", "S2A", ")", "." ] } ]
PMC11730311	EC50hαCGRP values generated in the presence of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EC50hαCGRP", "values", "generated", "in", "the", "presence", "of", "hαCGRP8", "-", "37N25K-C20DA-γGlu", "and", "hαCGRP8", "-", "37A36S", ",", "N25K-C20DA-γGlu", "." ] } ]
PMC10203589	In 103 OC patient samples, FGF18 expression was increased in serous and mucinous ovarian cancers by IHC as well as analysis of clinicopathological variables and patient outcomes, and was similarly significantly increased from adenoma to borderline tumor to type I cancer and then from type I to type II cancer (88).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "103", "OC", "patient", "samples", ",", "FGF18", "expression", "was", "increased", "in", "serous", "and", "mucinous", "ovarian", "cancers", "by", "IHC", "as", "well", "as", "analysis", "of", "clinicopathological", "variables", "and", "patient", "outcomes", ",", "and", "was", "similarly", "significantly", "increased", "from", "adenoma", "to", "borderline", "tumor", "to", "type", "I", "cancer", "and", "then", "from", "type", "I", "to", "type", "II", "cancer", "(", "88", ")", "." ] } ]
PMC11760643	The relative P2X7 expression on cells was determined as the difference between the MFI of anti‐P2X7 mAb stained cells and the corresponding FMO control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "P2X7", "expression", "on", "cells", "was", "determined", "as", "the", "difference", "between", "the", "MFI", "of", "anti‐P2X7", "mAb", "stained", "cells", "and", "the", "corresponding", "FMO", "control", "cells", "." ] } ]
PMC11549062	Western blot analyses of PDGFR‐β, PTP1B, and Rab5. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analyses", "of", "PDGFR‐β", ",", "PTP1B", ",", "and", "Rab5", ".", "(" ] } ]
PMC11754432	Co-localisation analysis revealed an increase in Mander’s M1 co-efficient (Fig. 4D) but no change in M2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-localisation", "analysis", "revealed", "an", "increase", "in", "Mander", "’s", "M1", "co-efficient", "(", "Fig.", "4D", ")", "but", "no", "change", "in", "M2", "." ] } ]
PMC11741906	The expression levels were normalized to SNORD95 and relative to A2780 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "expression", "levels", "were", "normalized", "to", "SNORD95", "and", "relative", "to", "A2780", "cells", "." ] } ]
PMC11190062	Proteasome inhibitors are the backbone of the most used drug combinations in MM treatment, but new drug classes have shown great efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteasome", "inhibitors", "are", "the", "backbone", "of", "the", "most", "used", "drug", "combinations", "in", "MM", "treatment", ",", "but", "new", "drug", "classes", "have", "shown", "great", "efficacy", "." ] } ]

PMC11788920

Figure 1E and F show these studies in which the number of viable cells in multi-well plates is quantified in the absence of CRISPR–dCas9 treatment and after being treated with RNP1, RNP2, RNP3, RNP1 + RNP2 (′RNP1 + 2′ in figures), or RNP2 + RNP3 (′RNP2 + 3′ in figures).

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PMC10329237

Furthermore, other proteins are also up-regulated during the EMT process including zinc finger transcriptional factors such as Snail1 and Slug (36).

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PMC9429973

Following combination therapy, we found a significant reduction in Calr-mutant donor chimerism, specifically in LT-HSCs and platelets, accompanied by reductions in LT-HSC frequency and platelet count.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "combination", "therapy", ",", "we", "found", "a", "significant", "reduction", "in", "Calr-mutant", "donor", "chimerism", ",", "specifically", "in", "LT-HSCs", "and", "platelets", ",", "accompanied", "by", "reductions", "in", "LT-HSC", "frequency", "and", "platelet", "count", "." ] } ]

PMC11757230

Some studies have reported differing effects of human MSCs on tumor cell growth in vitro and in vivo.

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PMC11786767

D: Confocal images of chromosomes and microtubules at prometaphase.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ":", "Confocal", "images", "of", "chromosomes", "and", "microtubules", "at", "prometaphase", "." ] } ]

PMC9429973

Main secondary EPs were overall response rate (ORR) and progression-free survival (PFS).

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PMC10747160

While this initially perplexed researchers, it has now been widely accepted that cell surface attachment receptors are capable of binding to the SARS-CoV-2 virion and facilitating efficient viral infection of cells that have poor hACE2 expression .

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PMC11795610

In brief, the differentiated keratinocytes were fixed with 4% paraformaldehyde for 15 min and then permeabilized with 0.5% triton X-100 for 10 min.

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PMC9429973

53% of patients with more than 5% BMB did not achieve a CR compared to 18% with less than 5% BMB. (

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PMC7171147

For drug treatments, cancer cells were serum starved and plated on COL11A1 extract for 48 h in media containing 1% FBS and treated with drugs (dasatinib, LY294002, MK2206 and dorsomorphin) for another 48 h. For cisplatin treatment, cancer cells were serum starved and cultured on uncoated plates, COL11A1-positive extract or COL11A1-negative extract in media containing 1% FBS for 24 h and treated with cisplatin for another 72 h. Cell viability was measured by CellTiter-Glo luminescent cell viability assay (Promega # G7572) using a Glomax Explorer Microplate Reader (Promega), according to the manufacturer’s protocols.

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PMC11775197

It has been proposed that the PPARβ/δ agonist GW501516 may contribute to the development of colitis-associated colon carcinogenesis, potentially through the increased expression of Glu1h and SLC1A5 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "proposed", "that", "the", "PPARβ/δ", "agonist", "GW501516", "may", "contribute", "to", "the", "development", "of", "colitis-associated", "colon", "carcinogenesis", ",", "potentially", "through", "the", "increased", "expression", "of", "Glu1h", "and", "SLC1A5", "." ] } ]

PMC11306331

Statistical test: Mann–Whitney U test.

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PMC8735881

In brief, the viruses were produced by transfecting HEK293T cells (6 × 10 cells in a P-100 mm dish) with 24 μg of plasmid encoding the molecular clone using a linear PEI transfection reagent.

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PMC10222971

Nowadays, many drugs based on natural products that contain a 1,4-naphthoquinone backbone in their chemical structure are used as anticancer agents, such as doxorubicin, daunorubicin, mitoxantrone and aclacinomycin A (Figure 1) .

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PMC8978939

At normal oxygen level, HIF-α is hydroxylated at proline residues, in this form is recognized by pVHL, leading to rapid ubiquitination and degradation by the proteasome (11, 12).

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PMC9429973

A. Al Raizah, M. Alzahrani, A. Hejazi, M. Almegren, T. Alshuaibi, A. Alaskar Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs.

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PMC5839394

The extracted DNA was suspended in 1 ml milliQ and transferred in cuvette for fluorescence analyses.

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PMC5839394

Flow cytometry analysis of DNA distribution in propidium iodide-stained cells. (

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PMC7039683

Some exceptions to the general pattern were observed (e.g., hspb9 and npm1b, Figure 1H); this might reflect the fact that enhancers do not always regulate an adjacent gene.

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PMC10547921

NIR-PIT drugs can form a new targeted anti-cancer platform with devices that irradiate infrared light to tumor sites.

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PMC11618052

In a recent publication from our lab, we describe the discovery of a novel class of 1,2,3-triazole/quinoline hybrids as antiproliferative compounds that act as multi-targeted inhibitors.

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PMC11661024

On the contrary, postbiotics can offer anti-inflammatory effects similar to probiotic bacteria, higher shelf life, and sustainability.

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PMC10898159

Fibroblast growth factors (FGFs) and their receptors (FGFR1-4) are universally expressed in human tissues and have an important effect on various cell physiologic processes ranging from cell proliferation, survival, and migration.

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PMC11271800

However, the combination of the two in a mouse model inhibited tumor progression and suppressed M1 to M2 polarization, which in turn reduced M2 TAM infiltration in GIST, thereby inhibiting tumor progression.

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PMC11711127

The inhibition of T cell proliferation by anti-PD-L1 Abs is primarily due to increased IFN-γ production, with a subsequent rise in NO production by macrophages (164).

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PMC9429973

Forty-seven (68%) patients had an identifiable provoking factor apart from MBL/CLL including second active malignancy (n=21), surgery (n=9), recent hospitalization (n=6), travel (n=4), trauma (n=3), line-associated VTE (n=3), and immobility (n=1).

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PMC3675084

Pan β-tubulin and β-actin were loading controls. (

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PMC11190538

Formulation of C-PC nanophytosomes was Patent registered under the No: EG/P/2022/1221.

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PMC11743316

Mitophagy plays a dual role in cancer and may either promote or suppress tumorigenesis, depending on the tumor type and molecular context .

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PMC11641630

Additionally, related to non-tuberculous mycobacteria, heat-killed Mycobacterium indicus pranii has been shown to inhibit melanoma cell invasion by reducing MMP-9 expression .

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PMC8973085

The NMR spectra were preserved on a Varian Mercury VX-400 NMR spectrometer (Varian, Palo Alto, CA).

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PMC9429973

Methods: 915 AML patients (498 < 65 years, 417 ≥ 65 years) treated at the University Hospital of Düsseldorf were analyzed.

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PMC11297139

The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.

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PMC11594588

In all analyzed organisms (bacteria and mammals), etheno DNA adducts induce different types of mutations such as base substitutions, frameshift mutations, and sister chromatid exchanges and chromosomal aberrations.

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PMC11705484

CMP9 showed a good safety profile, while CMP1 increased serum Urea and Crea levels, indicating kidney toxicity exerted by CMP1 (Figure 4I,J).

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PMC10212663

To verify whether the application of RANKL inhibitor has clinical benefit, 57 patients diagnosed as LUAD with bone metastases who have received chemotherapy (±targeted agents but not immunotherapy as stated beforehand) as well as concomitant RANKL inhibitor (denosumab) or phosphates were identified.

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PMC9119314

Furthermore, these compounds can be interrogated for gametocidal activity by exploring their activity against the male and female gametes.

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PMC11628309

These models closely replicate key features involved in PD pathology such as mitochondrial dysfunction, protein aggregation and ROS accumulation (Ke et al., 2021).

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PMC11741906

These studies focused on molecular drivers of chemoresistance and aimed to suggest miRNAs with prognostic potential.

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PMC11638255

Of note, neutrophils have been demonstrated to mediate ADCC against neuroblastoma in the presence of anti-GD2 antibody, illuminating a possible link to the enhanced tumor clearance conferred by immunocombination therapy in the Th-MYCN model (Fig. 1b,c).

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PMC9429973

Data was analyzed by SPSS version 23.0.

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PMC8973085

calcd for C29H22FN3O2S: C, 70.29; H, 4.47; N, 8.48.

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PMC11574271

Invasive growth of bladder cancer cells into the neighboring tissue is a critical event directly associated with tumor malignant progression, chemoresistance, and clinical outcome .

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PMC10919056

Destruction of GJB1 plays a role in promoting the occurrence and development of ovarian cancer and is not conducive to the action of chemical drugs (34).

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PMC11087301

Polyploid giant cancer cells (PGCCs) are a subgroup of dormant tumor tissue cells which exhibit CSC features and facilitate tumor recurrence.

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PMC9429973

Through genome-wide loss-of-function screens using CRISPR/Cas9 we identified that the transcriptional co-regulator strawberry notch homolog 2 (SBNO2) is an essential direct transcriptional target of STAT3 in transformed mHSPC.

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PMC11564322

The data are expressed as means ± SD of three independent experiments and presented as a percent of the control Cell number.

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PMC11755467

Indeed, no negative growth effect was seen for Enoxacin treatment, while nalidixic acid led to a significant loss of viability (IC50~75–115 µM), with a similar toxic effect seen for high amounts of DMSO (IC50~244–279 µM).

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PMC11515150

Cytotoxicity of 12 C CAR-NK cells and NT-NK cells against CD5 hematologic malignant cells was evaluated.

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PMC11803918

Second, the hybrid exosomes have the capability to activate the immune system, promoting antitumor immune responses, which may help in the long-term control of cancer and reduce the risk of tumor recurrence.

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PMC7723249

Treatment with EGTA, a Ca chelator, after the treatment with PMA, leads to complete opening of intercellular junctions and disrupting of the polarization of treated cells.

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PMC11683240

Values of median are given as x-fold of the untreated control (Con), mean ± SEM (n = 9 values from three independent experiments).

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PMC10936243

So, everybody is in charge of animal welfare at every stage and I think it’s not a matter of cost I would say, the cost is very minimal.” “

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PMC10178190

We also demonstrated that the combination of a platinum drug with fisetin and other flavonoids restored platinum drug sensitivity to OC cells that were co-cultured with MSC.

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PMC10788478

In this pathway, β‐catenin is engaged by a complex comprising glycogen synthase kinase 3β (GSK‐3β), adenomatous polyposis coli (APC), and Axin.

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PMC2614415

= p-value less than 0.0025 by students T-test.) (

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PMC9429973

As such, they are often a challenge to diagnose.

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PMC2196094

Using this technique, five novel proteases, designated RMCP-3, -4, -8, -9, and -10 were isolated from the RBL-1 cell line.

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PMC5839394

Proteomic map of SKBR3 control cells.

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PMC6442998

To assess the role of YAP pathway in GIST cells lines, we used verteporfin, an inhibitor of YAP/TEAD interaction .

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PMC8010066

The dried weight of alginate was measured as µg/mL. Antibiotic disks (MAST, UK) and E-tests (Liofilchem, Italy) were used to examine the strains` susceptibility to several antibiotics before and after their co-culture growth.

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PMC9429973

Median RUX duration was 4.0 months (IQR, 3.0–6.1) for refractory or intolerant patients and 11.7 months (IQR, 6.5–17.1) for those with PD.

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PMC11459296

Infiltration of human NK cells and T cells also showed a significant correlation with reduced leukemia multiorgan engraftment in PB, BM, liver, and spleen (online supplemental figure S1E).

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PMC11806106

Activation and deactivation of GPCRs are mostly measured in downstream signaling, indirect or amplified assays.

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PMC4270159

PDGFRα.p-AKT S473.AKT.p-ERK T202/Y204.ERK.pFRS2α Y196.FRS2α.β-tubulin [additional control].A. Loading control.iii.

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PMC11759543

BFTC 905 cell tumorsphere formation assay was simulated to mimic an in vitro tissue treatment experiment.

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PMC10589262

Colocalization of membranous MT-KIT with EEA1 and LAMP1 was clearly observed 15 and 30 min after tracking, and disappeared after 1 h (Supplementary Fig. S3B, C).

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PMC11225860

After each division the cell becomes notably larger, and presents with disfigured cellular morphology at the end of G2, before each division failure.

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PMC11740573

Moreover, we assessed the anti-bacterial properties of calcitriol, as well as its synergistic activity with antibiotics that are used for the treatment of AV.

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PMC11412752

After a 0.5 h infection, the cells were washed with PBS and subsequently cultured for an additional 0.5 h in DMEM-FBS (10%) supplemented with 100 μg/mL gentamicin (A620217; Sangon Biotech) to remove extracellular bacteria.

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PMC9429973

Although the incidence of breast cancer, and thereby the number of breast reconstructions, is on the rise, it is likely that the rapid increase in the number of BIA-ALCL cases since 2018 is due to increased awareness of this disease.

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PMC11534377

The variation in staining intensity reflects the relative quantity of cells that have migrated, with darker areas denoting higher densities of cells.

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PMC11411131

Then, transfected Cos-7 cells were treated with MeHg (0, or 6 µM) for 24 h. MeHg only reduced the HA signal while leaving the FLAG signal unchanged (Fig. 1C).

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PMC9429973

Effectiveness: 144 (81.4%) pt achieved CR after Induction1or2, of them 76pt were consolidated with alloSCT, 24pt received maintenance and 41pt proceed to W&W. Median OS for the whole population was not reached and the 24months OS was 68%.

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PMC6892818

mCD40L triggered reactive oxygen species (ROS) production, critical in apoptosis, and NADPH oxidase (Nox)-subunit p40phox phosphorylation, with Nox blockade abrogating apoptosis thus implying Nox-dependent initial ROS release.

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PMC11704135

According to the findings of this study, compounds 12, and 6 showed higher scavenging activity than the start compound 1, as the modification made on these compounds, through ethyl and benzoyl substitution, had resulted in 127.56, and 51.10%, respectively, increases in the DPPH scavenging activity of these compounds as compared to the start compound (Table 4).

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PMC11025866

However, since NaB is an HDACi, expression of a very large number of genes is altered by NaB (Table 2).

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PMC11799978

Depletion of FAP-expressing fibroblasts caused necrosis of tumor cells and CAFs in murine models of cancer.

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PMC11322866

GSK126 and AG126 exhibited antagonistic effects mainly on RPMI-8226 and OCI-MY5 cells ( Figure 4B).

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PMC11521786

3LL-R3 cells were treated with immune sera (heat inactivated and 1:20 diluted).

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PMC11686380

Polyclonal rabbit anti-Sept11 was prepared as described.

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PMC10154881

Thus, the ability to target only NECTIN4 is the advantage of rMV‐SLAMblind.

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PMC11366496

Batch effect is a common problem in statistical analysis, especially in biological and medical research.

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PMC9429973

Data were collected from 29 centers across North America (United States and Canada) and the European Union.

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PMC8041314

Expression of adenosine triphosphate-(ATP)-binding cassette (ABC) transporters in multidrug-resistant cancer remains a huge obstacle in cancer chemotherapy.

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PMC11774251

The anti-psoriatic mechanism of Tan-I involves the dysfunction of keratinocytes.

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PMC11632064

Treatment of MeWo cells with BI-D1870 reduced the expression of Dopachrome Tautomerase/TRP-2 (DCT), a modulator of the melanocytic state (Lenggenhager et al, 2014; Muccioli et al, 2023), while treatment with LJH685 had no impact (Fig 2K and L).

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PMC11568601

Considering the enrichment of the biological process “IRE1-mediated unfolded protein response”, it is reasonable to speculate that TGT may regulate the IRE1/CHOP pathway to trigger osteosarcoma cell apoptosis .

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PMC9429973

The light chain was Lambda in 50% of cases, whereas it is predominant (80%) in the literature (1), and cardiac involvement was the leading cause of morbidity and mortality as similar as what is reported (1).

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PMC9964635

Element analysis: C, 65.41; H, 7.69; N, 15.27; S, 11.65% (Figures S3–S5 and S8).

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PMC5417661

The fluorescence per well was measured in a FLUOStar Optima (BMG Labtech GmbH) and a survival index % (SI) for each compound-treated well was calculated with the equation: Compound-treated cells minus blank divided by control cells minus blank.

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PMC11748335

Notably, the number of loops in the long LOCK regions was significantly higher than that in the randomly selected regions, both across the entire genome and within the common PMDs.

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PMC10212663

We then validated this finding using the RNA‐sequencing data and clinical data from the TCGA database both in the advanced (Figure 2(a)) and non‐advanced settings (Figure S2A).

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PMC11730311

EC50hαCGRP values generated in the presence of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu.

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PMC10203589

In 103 OC patient samples, FGF18 expression was increased in serous and mucinous ovarian cancers by IHC as well as analysis of clinicopathological variables and patient outcomes, and was similarly significantly increased from adenoma to borderline tumor to type I cancer and then from type I to type II cancer (88).

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PMC11760643

The relative P2X7 expression on cells was determined as the difference between the MFI of anti‐P2X7 mAb stained cells and the corresponding FMO control cells.

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PMC11549062

Western blot analyses of PDGFR‐β, PTP1B, and Rab5. (

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PMC11754432

Co-localisation analysis revealed an increase in Mander’s M1 co-efficient (Fig. 4D) but no change in M2.

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PMC11741906

The expression levels were normalized to SNORD95 and relative to A2780 cells.

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PMC11190062

Proteasome inhibitors are the backbone of the most used drug combinations in MM treatment, but new drug classes have shown great efficacy.

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