Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9429973
The mean comorbidity score was 1.31 (SD 1.44).
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PMC11546117
Andersson et al. (2017) studied the transfer of the neurotoxic amino acid β-N-methylamino-alanine (BMAA) in the breast cancer epithelial MCF-7 cell line .
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PMC9429973
Results: To date, three patients have been treated at DL1 and two at DL2.
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PMC11543935
The indirect test with cell media incubated for 24 h with PP cubes shown in row two (Fig. 2A) had a RCVindirect = 115 %.
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PMC10761571
We observed that the Fe3O4@Glu-Gingerol increased the activity of the caspase 3 by 2.8 folds (Fig. 10a) and Fe3O4 NPs increased the activity by 1.38 folds (Fig. 10b).
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PMC11762280
B Photos of mice dorsal skin after different UVB irradiation doses and times (n = 4).
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PMC11626627
The 786-O, A498, and HEK-293 cell lines were purchased from the American Type Culture Collection (ATCC, Manassas, VA).
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PMC11740907
The results of our investigation are consistent with previous research that has investigated the surface characteristics of SLNs.68,69Figure 3The representation of transmission electron microscopy image (A), and scanning electron microscopy image (B) of P5W30-BW-SLNs.
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PMC10891340
The cell supernatant was then collected to measure TCID50 (B) and the infected cells were collected to detect DPV UL30 expression by Q-RT-PCR (C). (
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PMC11394730
The most prevalent and potent antioxidant in green tea for the chemoprevention of cancer is EGCG.
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PMC10547921
Cryptophycin irreversibly inhibits β-tubulin polymerization during mitosis, which can lead to cell cycle blockade in the G2/M phase and activate the apoptosis pathway, thereby producing picomolar antiproliferative capacity in vitro.
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PMC10778532
We also demonstrated that sunitinib treatment impacts VHL-C162F cell phenotype with an upregulation of EMT-related mesenchymal and proliferation associated markers.
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PMC11615101
P ≤0.05, ** P ≤0.01, *** P ≤0.001, **** P ≤0.0001).
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PMC9325715
Both of the mentioned models are simple and were shown to be useful for the description of the processes of protein interaction with such metals as Ag and Zn.
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PMC11772585
P < 0.05, **P < 0.01, ***P < 0.001.
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PMC11412721
This led to identify two homozygous ACKR4 KO clones, one (clone 4.14) obtained using gRNA #4 and one (clone 5.2) using gRNA #5 (Figure 4—figure supplement 3).
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PMC11394730
Emodin, a naturally occurring anthraquinone derivative that is a tyrosine kinase inhibitor and is present in the rhizomes and roots of many different plants , is widely used in traditional Chinese medicine as a laxative (Figure 7).
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PMC11225860
U2932 cells were treated synchronized with a double thymidine block over a two-day period.
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PMC11711345
Cytotoxicity is predicted in terms of Pa (probable activity) and Pi (probable inactivity), which range from 0 to 1.
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PMC7504302
Earlier MPM research on miRNAs and lncRNAs have been extensively reviewed elsewhere by Reid et al. and Singh et al., respectively .
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PMC11583690
This difference, which is not significant, still indicates the significant DTX loading potential of BPMO when compared with MSN.
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PMC9429973
D. Mehic, B. Jilma, C. Schörgenhofer, M. Colling, C. Ay, I. Pabinger, J. Gebhart Clinical Division of Hematology and Hemostaseology; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria Background: A majority of patients with a mild to moderate bleeding tendency (mild bleeding disorders, MBD) remains without a diagnosis, despite extensive laboratory investigations (bleeding of unknown cause, BUC).
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PMC11746942
B RPKM values of SPHK1, SPHK2, and SGPL1 in normal and psoriatic skin from the GSE54456 dataset.
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PMC9024365
During excitatory synapse development, pre-synaptic axon terminals responsible for the export of signaling molecules pair with post-synaptic dendritic spines that contain glutamate receptors, scaffolding molecules, and cytoskeletal elements (McAllister, 2007).
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PMC9479186
In SK-HEP-1 cells, the proportion of cells in the G1 phase of the Lv-shNDUFC1 infection group increased (75.02 ± 0.41% vs. 47.27 ± 0.20%, P < 0.001), and the proportion of cells in the S phase (7.82 ± 0.66% vs. 21.53 ± 0.38%, P < 0.001) and G2 phase decreased (17.16 ± 0.39% vs. 31.20 ± 0.42%, P < 0.001).
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PMC8140214
Effect of D-glucose and/ or quercetin on SOD activity in HepG2 cells after 48 (A) and 72 (B) hr treatment.
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PMC11721587
The bound protein was stripped with 2× SDS loading buffer and boiled for 5 min.
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PMC4485786
After 3 washes, the sections were incubated with Cy3- or Cy5-conjugated donkey anti-rabbit antibody and Cy3- or Cy5-conjugated donkey anti-mouse antibody (all from Dianova, Germany).
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PMC9895440
Cells were filtered to have >2.5 mean logcounts of their listed housekeeping genes and >0 logcounts for PTPRC (CD45) to exclude non-immune cells.
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PMC11597291
In the case of nCGO-4armPEG(10 kDa) particles, a burst effect occurred at pH 6.0.
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PMC9368503
Of these, both SYO-1 and HS-SY-II have previously been shown to be sensitive to PLK-1 inhibition while BET bromodomain inhibitors .
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PMC9429973
Due to reversible nature of epigenetic alteration, modulation of these mechanisms might constitute a successful therapeutic application in CLL.
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PMC11726183
Products having distinct biological characteristics can be formed by combining hydrazones with various functional groups.
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PMC11365983
Hydrocephalus, congenital heart disease and renal cysts exemplify additional cilia-associated phenotypes, that reflect roles in mechanosensation, chemosensation, and extracellular fluid movement.
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PMC10955424
Ovarian Cancer patients demographic and clinical characteristics.
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PMC4005030
et Zucc. (
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PMC9388315
The obtained lysates were used to measure activity LDH according to the manufacturers' instructions kit (Pars Azmun, Iran).
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PMC9429973
Of all the PTLDs, 52 (64.2%) were monomorphic, 18 (22.2%) polymorphic, 2 (2.5%) early lesions, and 9 (11.1%) were unknown.
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PMC9429973
Whereas the vast majority (50.5 million, 97%) of RNA-chromatin interactome were intra-chromosome, a small fraction (1.6 million, 3%) occurred inter chromosome.
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PMC11448304
Further gain/loss of function experiments showed that Khib modified EGFR level positively correlates with NSCLC cell radioresistance.
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PMC11512230
Cells were harvested, centrifuged, and resuspended in the flow cytometry buffer (PBS).
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PMC7823217
Breast cancer is the most frequently diagnosed cancer in women worldwide, with approximately 2.09 million new cases and 627,000 deaths in 2018, estimated by the WHO .
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PMC10440586
The GSEA plot in angiogenesis genes set of the TCGA dataset. (
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PMC11604830
The peak at 0 ppm corresponds to TSP‐d4, used for proton quantification.
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PMC10899471
It has been reported that BATF2 is primarily expressed in normal cells but not in the corresponding tumor cells, while the upregulation of BATF2 has been shown to inhibit cancer cell proliferation, angiogenesis, invasion and metastasis (13, 14), underscoring its importance in cancer therapy.
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PMC9727330
Lactate dehydrogenase (LDH) production LDH assay kit (Abc-65393) was used to assess LDH production in the fluid media collected from cultured-treated cells.
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PMC11682172
Table 1Number of proteins identified by LC-MS measurements.
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PMC10529414
RUNX proteins are transcriptional regulatory factors that require interaction with other proteins to increase or decrease their activity .
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PMC11388384
Because SCUBE1 interacts with the cholesterol group on SHH to promote its release from sender cells (13, 14), and because the cholesterol moiety was required for SCUBE1-mediated Hedgehog gradient expansion (SI Appendix, Fig. S8), we expected SCUBE1 to shift the SHH molecules from the membrane-bound fraction (~1 µm/s) to the faster fraction (~20 µm/s), in order to increase the effective diffusion rate.
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PMC11045125
The EBNA2 gene-directed guide sequence 5’-GTGGGAATTACGGAGTGA-3’was cloned into the pCEP-blasticidin vector, and 100 ng of vector was transfected into AG876 EBV infected Hela cells (in a 35 mm dish) using Lipofectamine 2000 following the manufacturer’s protocol.
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PMC11612794
Cells were treated with IAA for 12 h, fixed, and stained with an anti-FLAG antibody.
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PMC10976516
OVs have great potential to reverse immunological tumor tolerance and activate anti-tumor immunity.
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PMC9684669
In addition, we demonstrate that terfenadine interacts directly with calcium/calmodulin dependent protein kinase II delta (CAMK2D) and inhibits the subsequent ectopic activation of the CAMK2/cAMP responsive element binding protein 1 (CREB1) pathway in an ABCB1-mediated MDR ovarian cancer line, A2780-ADR.
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PMC4816271
Whilst a very small number of residual CAR-expressing T cells were detectable in the unmodified and SAR groups following CID treatment, it is unclear whether the cells retain sufficient CAR expression to display activity.
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PMC10547921
The dual-drug ADC showed selective and potent cytotoxicity against HER2-expressing cell lines and exhibited dual mechanisms of action consistent with the attached drugs.
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PMC11733919
Surprisingly, there were no statistically significant increases in the levels of two markers of apoptosis, namely, phosphatidylserine externalization or caspase 3 pools in MNP@CD26@17D-treated senescent skin cancer cells (Figure 4a).
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PMC9822769
From this sample, about 5 × 10 cells were taken out for the cellular accumulation analysis (see the previous section), whereas about 20 × 10 cells were taken out for the DNA platination analysis.
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PMC11727907
Images of ARPE-19 cells treated with IGF-1 reveal a time-dependent translocation of PKM2 in the nucleus.
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PMC11055443
Caco-2 cells were treated with secretome for 48h and then exposed to two concentrations of 5 × 10 CFU and 2 × 10 CFU Vibrio cholerae for 2h.
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PMC7642379
Genomic comparison between HEK293 cell lines based on Spearman correlation coefficients of read counts.
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PMC11380454
Moreover, the same concentrations of AS101 and SAS, which effectively decreased tumor volume, correlated with decreased PD-L1 expression on tumor cells (Fig. 9B and Fig. S6B).
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PMC7189327
We also noted that PTCH1 exerted critical biological roles in the BCC pathway (Figure 2).
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PMC11706776
B Membrane potential measures of shRNA CT or shRNA 908 spheroids treated 7 days with doxycycline (0.5 µg/mL) (N = 7).
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PMC9429973
Results: A total of 66 elderly patients with DLBCL aged >60 years were identified.
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PMC6268318
The aqueous and EtOH extracts showed significant inhibitory activity against HIV-1 with an IC50 value of 2.5 and 2.9 µg/mL, respectively (Table 1).
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PMC11269933
Combining a series of molecular assays, we demonstrated that MAPK/ERK is the upstream kinase and regulatory pathway for this site.
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PMC9429973
The impact of different viral variants on outcomes is also a matter of debate.
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PMC10988555
Ex ovo chick embryo yolk sac membrane (YSM) in vivo assay was performed as previously described.
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PMC9429973
1 patient had PD at month 1 and was unable to receive further trial treatment.
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PMC11678368
The conformational differences between the complexes are closely related to the rotation of the aldehyde group in the ligands, as shown in Figure 1a–d. Theoretical studies have been performed for each ligand in two different conformations, which differ in the relative orientation of the carbonyl (C8=O1) and pyrrole (C3=C2) groups along the exocyclic C3–C8 bond.
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PMC9429973
26/28 pts were refractory to PI, 26/28 pts to IMiDs.
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PMC5600151
The growth of the molecule starts from the ends of the chain, beginning by integrating the various branching points with other monomers that will constitute the dendrimers.
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PMC10778532
This slowed down proliferation is in accordance with the observation that in several clinical trials, a clinical beneficial response to TKI treatment has been observed.
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PMC11719944
Our findings indicated an increase in the expression of CD8+ TIGIT+ potentially exhausted, while cells CD4+ TIGIT+ did not show a similar increase.
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PMC10470467
Subsequent analysis confirmed the hypothesis.
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PMC11407042
Extend the incubation time if digestion is incomplete, but do not exceed 5 min.5.Discard trypsin and add 5 mL FBS-containing DMEM.6.Resuspend cells thoroughly by gently pipetting.7.Add 20 μL cell suspension to Count Star cell counter plate.8.Determine the cell number three times on the Count Star automated cell counter.9.Seed 1.5×10 cells into each well in a total volume of 100 μL.10.Shake the plate gently, and observe under the microscope to ensure cells have spread evenly.
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PMC11397654
The whole series of functionalised macrocycles was then patented due to their antibacterial, antiangiogenic, and antitumour activity .
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PMC9429973
All, except NRAS (p=0.055), had a statistically significant Risk-Ratio when included in the Poisson regression model.
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PMC9512971
The median interval between the onset of symptoms (date of positive test for asymptomatic patients) and the date of registration was 4 days (range 0–5 days).
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PMC9220170
Thus, according to the available data, it becomes clear that both selenoproteins are important for the normal development of the brain, and their expression in various brain cancer cells is quite high.
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PMC11653168
The suppression of p-STAT3 without affecting total STAT3 levels further supports the role of Stattic as a selective inhibitor of STAT3 signaling, which could underlie its therapeutic potential in T-ALL.
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PMC11621493
PLA2G4D is expressed in keratinocytes and upregulated in psoriasis indicating a multifaceted role in the regulation of cell function (30, 32).
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PMC4369959
Thus, 6-gingerol suppresses the invasive activity of PANC-1 cells .
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PMC11724582
α-SMA and FAP expression was evaluated by western blotting.
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PMC10878518
Our results suggest that the OBP-401-based GFP expression system is a useful tool for predicting the therapeutic efficacy of oncolytic virotherapy on bone and soft-tissue sarcomas.
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PMC11633763
Nevertheless, there is still a deficiency in the HK2 regulation system in osteosarcoma.
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PMC5035325
Co-expression of both molecules on lung sections was evaluated by a double immunofluorescence method: 3LL-model (e) and 4T1-model (h).
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PMC10553757
We hypothesised that this early postpartum rise in serum GH may increase mammary metabolism in order to stimulate milk synthesis after child-birth.
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PMC11697703
To test this hypothesis, we first carried out miR-193b∼365 cluster GoF and LoF experiments in cultures enriched in corticospinal and other deep-layer neurons and evaluated neurite branching (Figures 4A–4C).
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PMC11699042
For DGEA between two samples, genes with Padj ≤ 0.01, |log2(FC) | > 1 were considered as DEG.
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PMC11319300
Conversely, in normal cells, the transcription of MYEOV remains inactive, largely attributed to DNA methylation (Fang et al., 2019; Liang et al., 2020).
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PMC9429973
Other combinations or drugs, i.e., isavuconazole, voriconazole, were used due to renal toxicity related to amphotericin B use.
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PMC7762347
Viability of HepG2 cells was determined after 24 and 72 h of exposure to pure cyanotoxins and their combinations with the MTS tetrazolium reduction assay in accordance with the manufacturer’s protocol.
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PMC11698348
In HFs, Elf5 is consistently expressed in the highly proliferative and differentiating keratinocytes in the hair bulb matrix as well as in anagen HF bulge region (D5-D12, arrows).
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PMC11754784
5 µl of Ni (30 mM) was dropped to the freshly torn mica’s surface to enhance the adhesion of the DNA samples.
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PMC11551844
Aliquots (50 μL) of this cell suspension were added to the plates.
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PMC11127909
XF96 cell culture microplates were seeded with OS cells at a density of 1 × 10 cells per well.
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PMC11365427
This approach demonstrated significant inhibitory effects on MM progression and offered protective effects against bone marrow damage.
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PMC11019355
Figure 1ATAC-STARR-seq to characterize regulatory effects on human and rhesus macaque expression differencesCreated with BioRender.com.
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PMC10454535
The 5 μM PIN/5 nM BTZ combination showed the greatest cytotoxic effect out of the tested combinations (Figure 3a).
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