OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11502327	Physical encapsulation and front-end carrier connection are two major strategies for drug delivery systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physical", "encapsulation", "and", "front-end", "carrier", "connection", "are", "two", "major", "strategies", "for", "drug", "delivery", "systems", "." ] } ]
PMC11718817	Importantly, nigericin treatment resulted in a slight increase in early macrophage infiltration into spheroids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "nigericin", "treatment", "resulted", "in", "a", "slight", "increase", "in", "early", "macrophage", "infiltration", "into", "spheroids", "." ] } ]
PMC9428827	Charych et al. developed a modified IL-2, with a site-directed PEG attachment on the alpha surface of the molecule; the modified IL-2 (NKTR-214) also increased the CD8/Tregs ratio and has a higher half-life, which could be an advantage for treatment schedule but also a problem considering the toxic effects associated with the IL-2 molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Charych", "et", "al.", "developed", "a", "modified", "IL-2", ",", "with", "a", "site-directed", "PEG", "attachment", "on", "the", "alpha", "surface", "of", "the", "molecule", ";", "the", "modified", "IL-2", "(", "NKTR-214", ")", "also", "increased", "the", "CD8/Tregs", "ratio", "and", "has", "a", "higher", "half-life", ",", "which", "could", "be", "an", "advantage", "for", "treatment", "schedule", "but", "also", "a", "problem", "considering", "the", "toxic", "effects", "associated", "with", "the", "IL-2", "molecule", "." ] } ]
PMC11585565	The medium was replaced with antibiotic-free Opti-MEM reduced serum medium (Gibco) supplemented with 40 mM Mg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "was", "replaced", "with", "antibiotic-free", "Opti-MEM", "reduced", "serum", "medium", "(", "Gibco", ")", "supplemented", "with", "40", "mM", "Mg", "." ] } ]
PMC9429973	When subdivided according to IGHV status, the best ORR was 88% in IGHV mutated and 91% in IGHV unmutated patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "subdivided", "according", "to", "IGHV", "status", ",", "the", "best", "ORR", "was", "88", "%", "in", "IGHV", "mutated", "and", "91", "%", "in", "IGHV", "unmutated", "patients", "." ] } ]
PMC6835428	Indeed, its targeting resulted in enhanced cisplatin-induced apoptosis in OC spheroids .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "its", "targeting", "resulted", "in", "enhanced", "cisplatin-induced", "apoptosis", "in", "OC", "spheroids", "." ] } ]
PMC10154881	Dead cells were stained with fixable viability dye 506 (FVD506) (eBiosciences) according to the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dead", "cells", "were", "stained", "with", "fixable", "viability", "dye", "506", "(", "FVD506", ")", "(", "eBiosciences", ")", "according", "to", "the", "manufacturer", "'s", "instructions", "." ] } ]
PMC11209164	This medium was supplemented with 1% penicillin–streptomycin (Gibco) and 10% fetal bovine serum (FBS), obtained from VWR (Mississauga, ON, Canada), to support optimal cell growth and maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "medium", "was", "supplemented", "with", "1", "%", "penicillin", "–", "streptomycin", "(", "Gibco", ")", "and", "10", "%", "fetal", "bovine", "serum", "(", "FBS", ")", ",", "obtained", "from", "VWR", "(", "Mississauga", ",", "ON", ",", "Canada", ")", ",", "to", "support", "optimal", "cell", "growth", "and", "maintenance", "." ] } ]
PMC10547921	However, its toxic side effects, such as neurotoxicity and gastrointestinal reactions, were also severe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "its", "toxic", "side", "effects", ",", "such", "as", "neurotoxicity", "and", "gastrointestinal", "reactions", ",", "were", "also", "severe", "." ] } ]
PMC11678130	On the other hand, 1% SDS, selected as a positive control, caused hemorrhage, coagulation, and lysis immediately after its local application on the CAM, inducing a severe irritant effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "1", "%", "SDS", ",", "selected", "as", "a", "positive", "control", ",", "caused", "hemorrhage", ",", "coagulation", ",", "and", "lysis", "immediately", "after", "its", "local", "application", "on", "the", "CAM", ",", "inducing", "a", "severe", "irritant", "effect", "." ] } ]
PMC11757131	Detection of triglyceride synthesis using the Applygen Technologies, Inc. triglyceride test kit. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detection", "of", "triglyceride", "synthesis", "using", "the", "Applygen", "Technologies", ",", "Inc.", "triglyceride", "test", "kit", ".", "(" ] } ]
PMC11617590	We also analyzed the effects of SFN on the expression of β‐catenin in the cytoplasm and nuclear fractions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "analyzed", "the", "effects", "of", "SFN", "on", "the", "expression", "of", "β‐catenin", "in", "the", "cytoplasm", "and", "nuclear", "fractions", "." ] } ]
PMC11637284	In contrast to most other mitochondrial OM-IM contact sites, the trypanosomal TAC is a permanent structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", "to", "most", "other", "mitochondrial", "OM-IM", "contact", "sites", ",", "the", "trypanosomal", "TAC", "is", "a", "permanent", "structure", "." ] } ]
PMC11594588	The clinical conditions most associated with venous thrombosis are generally related to the elements of Virchow’s triad .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clinical", "conditions", "most", "associated", "with", "venous", "thrombosis", "are", "generally", "related", "to", "the", "elements", "of", "Virchow", "’s", "triad", "." ] } ]
PMC7192625	Bait nodes are additionally labelled with the name of the gene whose promoter was targeted by the capture system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bait", "nodes", "are", "additionally", "labelled", "with", "the", "name", "of", "the", "gene", "whose", "promoter", "was", "targeted", "by", "the", "capture", "system", "." ] } ]
PMC3681794	In U2OS cells there was a significant reduction in apoptosis measured by morphological changes (p<0.05–001 2-tailed student t-test) (Figure 1B) and annexin V/7-AAD positivity (p<0.05–0.01 2-tailed student t-test) (Figure 1C), and a reduction in levels of cleaved caspase-3 and PARP on western blotting (Figure 1D) in hypoxia compared to normoxia.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "U2OS", "cells", "there", "was", "a", "significant", "reduction", "in", "apoptosis", "measured", "by", "morphological", "changes", "(", "p<0.05–001", "2-tailed", "student", "t-test", ")", "(", "Figure", "1B", ")", "and", "annexin", "V/7-AAD", "positivity", "(", "p<0.05–0.01", "2-tailed", "student", "t-test", ")", "(", "Figure", "1C", ")", ",", "and", "a", "reduction", "in", "levels", "of", "cleaved", "caspase-3", "and", "PARP", "on", "western", "blotting", "(", "Figure", "1D", ")", "in", "hypoxia", "compared", "to", "normoxia", "." ] } ]
PMC11496728	Improving cell engineering for transient production can not only increase the expression level of difficult-to-express proteins, but also alter the host cell background to improve strong indicators of robust performance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Improving", "cell", "engineering", "for", "transient", "production", "can", "not", "only", "increase", "the", "expression", "level", "of", "difficult-to-express", "proteins", ",", "but", "also", "alter", "the", "host", "cell", "background", "to", "improve", "strong", "indicators", "of", "robust", "performance", "." ] } ]
PMC11696659	An association between abnormally shorter telomeres and increased risk or increased mortality in lung cancer had been reported .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "association", "between", "abnormally", "shorter", "telomeres", "and", "increased", "risk", "or", "increased", "mortality", "in", "lung", "cancer", "had", "been", "reported", "." ] } ]
PMC11657695	Interestingly, reduction of EWS::ERG expression significantly reduces KCNA2 expression in 2 of the 3 cell lines tested (Figure S4B).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "reduction", "of", "EWS::ERG", "expression", "significantly", "reduces", "KCNA2", "expression", "in", "2", "of", "the", "3", "cell", "lines", "tested", "(", "Figure", "S4B).Fig", "." ] } ]
PMC8073654	Overall, these accumulated results indicated that the extracts and components of the Z. cassumunar possess potential value in the prevention and treatment of various diseases related to inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "these", "accumulated", "results", "indicated", "that", "the", "extracts", "and", "components", "of", "the", "Z.", "cassumunar", "possess", "potential", "value", "in", "the", "prevention", "and", "treatment", "of", "various", "diseases", "related", "to", "inflammation", "." ] } ]
PMC11420784	3-MA treatment reduced the amounts of LC3-II in ΔpldA-infected 5637 cells and mouse bladders to levels similar to those in WT or ΔpldA+ infected (Figure 2C and 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3-MA", "treatment", "reduced", "the", "amounts", "of", "LC3-II", "in", "ΔpldA-infected", "5637", "cells", "and", "mouse", "bladders", "to", "levels", "similar", "to", "those", "in", "WT", "or", "ΔpldA+", "infected", "(", "Figure", "2C", "and", "2D", ")", "." ] } ]
PMC9429973	Aims: While multiple case reports document that these patients have hematological response to long term corticosteroid therapy, we hypothesized that inhibition of cyclooxygenase (COX) upstream of thromboxane synthase in the arachidonic acid pathway may be effective in this condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "While", "multiple", "case", "reports", "document", "that", "these", "patients", "have", "hematological", "response", "to", "long", "term", "corticosteroid", "therapy", ",", "we", "hypothesized", "that", "inhibition", "of", "cyclooxygenase", "(", "COX", ")", "upstream", "of", "thromboxane", "synthase", "in", "the", "arachidonic", "acid", "pathway", "may", "be", "effective", "in", "this", "condition", "." ] } ]
PMC10926885	NDE1 was more abundant in SARC when monocytes and leukocyte‐mediated immunity were differentiating (Figure S7F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NDE1", "was", "more", "abundant", "in", "SARC", "when", "monocytes", "and", "leukocyte‐mediated", "immunity", "were", "differentiating", "(", "Figure", "S7F", ")", "." ] } ]
PMC11534035	Colony formation relative to siRNA control in A431 (C, D) and CAL39 cells (E, F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colony", "formation", "relative", "to", "siRNA", "control", "in", "A431", "(", "C", ",", "D", ")", "and", "CAL39", "cells", "(", "E", ",", "F", ")", "." ] } ]
PMC9429973	Finally, we assessed the applicability of using commonly available EDTA tubes and RNA stabilizing PAXgene tubes for bone marrow sampling, RNA isolation and whole transcriptome sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "assessed", "the", "applicability", "of", "using", "commonly", "available", "EDTA", "tubes", "and", "RNA", "stabilizing", "PAXgene", "tubes", "for", "bone", "marrow", "sampling", ",", "RNA", "isolation", "and", "whole", "transcriptome", "sequencing", "." ] } ]
PMC11066331	Finally, PLS-DA with 100 % accuracy (Cl = 94.7–100 %).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "PLS-DA", "with", "100", "%", "accuracy", "(", "Cl", "=", "94.7–100", "%", ")", "." ] } ]
PMC11759543	∗∗∗ and ###p < 0.001, ∗∗p < 0.01.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗∗∗", "and", "#", "#", "#", "p", "<", "0.001", ",", "∗∗p", "<", "0.01", "." ] } ]
PMC7553912	Kidney stone disease, also known as urolithiasis, is a common urologic disorder and is associated with the development of chronic kidney disease (CKD) and end-stage renal disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kidney", "stone", "disease", ",", "also", "known", "as", "urolithiasis", ",", "is", "a", "common", "urologic", "disorder", "and", "is", "associated", "with", "the", "development", "of", "chronic", "kidney", "disease", "(", "CKD", ")", "and", "end-stage", "renal", "disease", "." ] } ]
PMC10048572	Moreover, time point analysis is unable to provide information concerning clonal evolution of tumor cells, that could explain the resistance of the tumor to chemotherapy and targeted therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "time", "point", "analysis", "is", "unable", "to", "provide", "information", "concerning", "clonal", "evolution", "of", "tumor", "cells", ",", "that", "could", "explain", "the", "resistance", "of", "the", "tumor", "to", "chemotherapy", "and", "targeted", "therapy", "." ] } ]
PMC11665584	Furthermore, PITX1 skin healed significantly faster than control skin via increased keratinocyte activation and migration and a tunable inflammatory environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "PITX1", "skin", "healed", "significantly", "faster", "than", "control", "skin", "via", "increased", "keratinocyte", "activation", "and", "migration", "and", "a", "tunable", "inflammatory", "environment", "." ] } ]
PMC11437637	Shake and mix thoroughly, centrifuge at 1100rpm for 5 minutes, and discard the supernatant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shake", "and", "mix", "thoroughly", ",", "centrifuge", "at", "1100rpm", "for", "5", "minutes", ",", "and", "discard", "the", "supernatant", "." ] } ]
PMC9424261	The liver is the sixth most common site of primary cancers, but liver cancer is the third leading cause of cancer-related death globally .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "liver", "is", "the", "sixth", "most", "common", "site", "of", "primary", "cancers", ",", "but", "liver", "cancer", "is", "the", "third", "leading", "cause", "of", "cancer-related", "death", "globally", "." ] } ]
PMC11588008	Remove the cell culture medium and wash the cells once with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remove", "the", "cell", "culture", "medium", "and", "wash", "the", "cells", "once", "with", "PBS", "." ] } ]
PMC11545737	After entering the cell, S. flexneri lyses the vacuole and reaches the cell cytosol .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "entering", "the", "cell", ",", "S.", "flexneri", "lyses", "the", "vacuole", "and", "reaches", "the", "cell", "cytosol", "." ] } ]
PMC9429973	This WGS cohort comprised 399 CLL, 155 diffuse large B-cell lymphomas (DLBCL), 110 Burkitt lymphomas (BL), 61 mantle cell lymphomas (MCL), and 37 follicular lymphomas (FL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "WGS", "cohort", "comprised", "399", "CLL", ",", "155", "diffuse", "large", "B-cell", "lymphomas", "(", "DLBCL", ")", ",", "110", "Burkitt", "lymphomas", "(", "BL", ")", ",", "61", "mantle", "cell", "lymphomas", "(", "MCL", ")", ",", "and", "37", "follicular", "lymphomas", "(", "FL", ")", "." ] } ]
PMC9786247	In brief, C. burnetii aliquots were prepared with 1 × 10 bacterial cells per ml NaCl solution, stored at −80 °C, thawed at ambient temperature and resuspended thoroughly for at least 1 min to separate bacterial agglutination immediately prior to inoculation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "C.", "burnetii", "aliquots", "were", "prepared", "with", "1", "×", "10", "bacterial", "cells", "per", "ml", "NaCl", "solution", ",", "stored", "at", "−80", "°", "C", ",", "thawed", "at", "ambient", "temperature", "and", "resuspended", "thoroughly", "for", "at", "least", "1", "min", "to", "separate", "bacterial", "agglutination", "immediately", "prior", "to", "inoculation", "." ] } ]
PMC11659734	Visible precipitate was observed at 60 μM and above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visible", "precipitate", "was", "observed", "at", "60", "μM", "and", "above", "." ] } ]
PMC10955424	According to our previous finding, crizotinib also inhibits JAK2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "our", "previous", "finding", ",", "crizotinib", "also", "inhibits", "JAK2", "." ] } ]
PMC11633763	Additionally, USP22 knockdown shortened the half‐life of β‐catenin, and MG132 treatment blocked the effects of USP22 knockdown or overexpression on β‐catenin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "USP22", "knockdown", "shortened", "the", "half‐life", "of", "β‐catenin", ",", "and", "MG132", "treatment", "blocked", "the", "effects", "of", "USP22", "knockdown", "or", "overexpression", "on", "β‐catenin", "." ] } ]
PMC11389534	Specialised intestinal epithelial cells, such as Paneth cells, are capable of secreting a variety of immune mediators that help regulate host immune responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specialised", "intestinal", "epithelial", "cells", ",", "such", "as", "Paneth", "cells", ",", "are", "capable", "of", "secreting", "a", "variety", "of", "immune", "mediators", "that", "help", "regulate", "host", "immune", "responses", "." ] } ]
PMC10589262	Several studies on GISTs have assumed that MT-KIT localized in the PM delivers downstream signaling .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "studies", "on", "GISTs", "have", "assumed", "that", "MT-KIT", "localized", "in", "the", "PM", "delivers", "downstream", "signaling", "." ] } ]
PMC11448304	In this article, a lung adenocarcinoma cell line, radioresistant A549 (RA549), was generated by exposure to a series of irradiation.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "article", ",", "a", "lung", "adenocarcinoma", "cell", "line", ",", "radioresistant", "A549", "(", "RA549", ")", ",", "was", "generated", "by", "exposure", "to", "a", "series", "of", "irradiation", "." ] } ]
PMC10154097	Another study indicated that miR-381 inhibited epithelial ovarian cancer cell behaviors by suppressing YY1 which corroborates our findings .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "study", "indicated", "that", "miR-381", "inhibited", "epithelial", "ovarian", "cancer", "cell", "behaviors", "by", "suppressing", "YY1", "which", "corroborates", "our", "findings", "." ] } ]
PMC11597291	The reaction mixture was bath-sonicated in an ice-bath for 30 min and then gently stirred for 24 h at ambient temperature in the dark.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "mixture", "was", "bath-sonicated", "in", "an", "ice-bath", "for", "30", "min", "and", "then", "gently", "stirred", "for", "24", "h", "at", "ambient", "temperature", "in", "the", "dark", "." ] } ]
PMC9429973	Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are recurrently identified, actionable driver events in adult patients with AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Somatic", "mutations", "in", "isocitrate", "dehydrogenase", "1", "and", "2", "(", "IDH1/2", ")", "are", "recurrently", "identified", ",", "actionable", "driver", "events", "in", "adult", "patients", "with", "AML", "." ] } ]
PMC11742670	Conversely, features such as SdNH, StCH, SsSH, StN, SssS, -0.10 < mZagreb2 < = 0.41, -0.42 < piPC8 < = 0.20, SdsCH, -0.11 < Sm < = 0.44, -0.41 < Xc-6d < = 0.23, -0.13 < TopoPSA < = 0.24, -1.45 < SRW09 < = 0.60, -0.63 < TSRW10 < = 0.01, SsCl, and SsI exhibit negative effects on IC50 predictions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "features", "such", "as", "SdNH", ",", "StCH", ",", "SsSH", ",", "StN", ",", "SssS", ",", "-0.10", "<", "mZagreb2", "<", "=", "0.41", ",", "-0.42", "<", "piPC8", "<", "=", "0.20", ",", "SdsCH", ",", "-0.11", "<", "Sm", "<", "=", "0.44", ",", "-0.41", "<", "Xc-6d", "<", "=", "0.23", ",", "-0.13", "<", "TopoPSA", "<", "=", "0.24", ",", "-1.45", "<", "SRW09", "<", "=", "0.60", ",", "-0.63", "<", "TSRW10", "<", "=", "0.01", ",", "SsCl", ",", "and", "SsI", "exhibit", "negative", "effects", "on", "IC50", "predictions", "." ] } ]
PMC5311252	The top scoring network in this analysis was centered on E2F1 (Supplementary Figure 4d), further supporting a role of oncomotif-miRNAs in regulation of tumor cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "scoring", "network", "in", "this", "analysis", "was", "centered", "on", "E2F1", "(", "Supplementary", "Figure", "4d", ")", ",", "further", "supporting", "a", "role", "of", "oncomotif-miRNAs", "in", "regulation", "of", "tumor", "cell", "proliferation", "." ] } ]
PMC9429973	Inclusion/exclusion criteria, and the design and schedule of the intense immune and safety monitoring will be presented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inclusion/exclusion", "criteria", ",", "and", "the", "design", "and", "schedule", "of", "the", "intense", "immune", "and", "safety", "monitoring", "will", "be", "presented", "." ] } ]
PMC6642070	Lactate production in A-204 cells exposed to atorvastatin (Atr), pitavastatin (Pit), simvastatin (Sim), rosuvastatin (Ros), and lovastatin (Lov) at 10 μM for 48 h (n = 3). (	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lactate", "production", "in", "A-204", "cells", "exposed", "to", "atorvastatin", "(", "Atr", ")", ",", "pitavastatin", "(", "Pit", ")", ",", "simvastatin", "(", "Sim", ")", ",", "rosuvastatin", "(", "Ros", ")", ",", "and", "lovastatin", "(", "Lov", ")", "at", "10", "μM", "for", "48", "h", "(", "n", "=", "3", ")", ".", "(" ] } ]
PMC10452486	Evidently, group (iii) may represent a neo-HLA class which may be the progenitors of other HLA classes of proto-HLA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Evidently", ",", "group", "(", "iii", ")", "may", "represent", "a", "neo-HLA", "class", "which", "may", "be", "the", "progenitors", "of", "other", "HLA", "classes", "of", "proto-HLA", "." ] } ]
PMC10900886	EV-D68 circulation was limited during the pandemic, partly due to COVID-19 measures, but EV-D68-associated severe respiratory illnesses have been rising in several countries since 2021 and 2022 due to easing of COVID-19 measures (6, 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EV-D68", "circulation", "was", "limited", "during", "the", "pandemic", ",", "partly", "due", "to", "COVID-19", "measures", ",", "but", "EV-D68-associated", "severe", "respiratory", "illnesses", "have", "been", "rising", "in", "several", "countries", "since", "2021", "and", "2022", "due", "to", "easing", "of", "COVID-19", "measures", "(", "6", ",", "7", ")", "." ] } ]
PMC11682525	Hydrogen peroxide was used at concentrations ranging from 200 to 2000 micromolar, and it was diluted in a complete medium ( 15 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydrogen", "peroxide", "was", "used", "at", "concentrations", "ranging", "from", "200", "to", "2000", "micromolar", ",", "and", "it", "was", "diluted", "in", "a", "complete", "medium", "(", "15", ")", "." ] } ]
PMC9635307	Differences were considered to be statistically significant when p value < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "were", "considered", "to", "be", "statistically", "significant", "when", "p", "value", "<", "0.05", "." ] } ]
PMC11240571	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC11357960	Recent studies have found that, during anti-PD-1 immunotherapy, only a small fraction of tumor-infiltrating lymphocytes can specifically recognize and attack cancer cells to achieve therapeutic effects (20, 21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "found", "that", ",", "during", "anti-PD-1", "immunotherapy", ",", "only", "a", "small", "fraction", "of", "tumor-infiltrating", "lymphocytes", "can", "specifically", "recognize", "and", "attack", "cancer", "cells", "to", "achieve", "therapeutic", "effects", "(", "20", ",", "21", ")", "." ] } ]
PMC11765243	Intracellular signals were determined as described in detail in .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intracellular", "signals", "were", "determined", "as", "described", "in", "detail", "in", "." ] } ]
PMC11740207	Correlation and network analyses will further uncover key genes and interactions driving the unique properties of VSELSCs and VSLSLCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "and", "network", "analyses", "will", "further", "uncover", "key", "genes", "and", "interactions", "driving", "the", "unique", "properties", "of", "VSELSCs", "and", "VSLSLCs", "." ] } ]
PMC9429973	Two patients had a fatal outcome due to the development of pneumonia and subsequent sepsis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "patients", "had", "a", "fatal", "outcome", "due", "to", "the", "development", "of", "pneumonia", "and", "subsequent", "sepsis", "." ] } ]
PMC7840816	The sequences corresponding to the siRNA of SOX9 were 5′-GCAGCGACGUCAUCUCCAAdTdT-3′ (sense) and 5′-dTdTCGUCGCUGCAGUAGAGGUU-3′ (antisense).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sequences", "corresponding", "to", "the", "siRNA", "of", "SOX9", "were", "5′-GCAGCGACGUCAUCUCCAAdTdT-3′", "(", "sense", ")", "and", "5′-dTdTCGUCGCUGCAGUAGAGGUU-3′", "(", "antisense", ")", "." ] } ]
PMC5417661	Control cells were treated with the vehicle only.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "cells", "were", "treated", "with", "the", "vehicle", "only", "." ] } ]
PMC11422497	TUNEL assay was performed to determine the cell apoptosis rate in Xenograft tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TUNEL", "assay", "was", "performed", "to", "determine", "the", "cell", "apoptosis", "rate", "in", "Xenograft", "tumors", "." ] } ]
PMC10198699	For example, the fact that one may not trade in cannabis does not mean that one cannot own cannabis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "the", "fact", "that", "one", "may", "not", "trade", "in", "cannabis", "does", "not", "mean", "that", "one", "can", "not", "own", "cannabis", "." ] } ]
PMC9100622	One of the polymorphisms observed in EwS patients was shown to increase the length of a GGAA microsatellite repeat motif, thus inducing increased binding of EWSR1-FLI1 and, consequently, increased EGR2 expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "polymorphisms", "observed", "in", "EwS", "patients", "was", "shown", "to", "increase", "the", "length", "of", "a", "GGAA", "microsatellite", "repeat", "motif", ",", "thus", "inducing", "increased", "binding", "of", "EWSR1-FLI1", "and", ",", "consequently", ",", "increased", "EGR2", "expression", "." ] } ]
PMC11803149	gRNA was mixed with Cas9 and incubated for 10 min at RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "gRNA", "was", "mixed", "with", "Cas9", "and", "incubated", "for", "10", "min", "at", "RT", "." ] } ]
PMC11665584	The activated keratinocyte genes Krt6a, Krt16, and Krt17 all had significant enrichment of both PITX1 and H3K4me3 at the TSS, correlating with the increased transcription of these genes (Figure 3B and Supplemental Figure 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "activated", "keratinocyte", "genes", "Krt6a", ",", "Krt16", ",", "and", "Krt17", "all", "had", "significant", "enrichment", "of", "both", "PITX1", "and", "H3K4me3", "at", "the", "TSS", ",", "correlating", "with", "the", "increased", "transcription", "of", "these", "genes", "(", "Figure", "3B", "and", "Supplemental", "Figure", "6B", ")", "." ] } ]
PMC11790599	In contrast to TSL, which induces catastrophic macropinocytosis (methuosis) leading to cell death in ER+, HER2+/EGFR+ breast cancer cell lines, no cytoplasmic vacuoles were observed in NTSL-treated cells (data not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", "to", "TSL", ",", "which", "induces", "catastrophic", "macropinocytosis", "(", "methuosis", ")", "leading", "to", "cell", "death", "in", "ER+", ",", "HER2+/EGFR+", "breast", "cancer", "cell", "lines", ",", "no", "cytoplasmic", "vacuoles", "were", "observed", "in", "NTSL-treated", "cells", "(", "data", "not", "shown", ")", "." ] } ]
PMC7334607	Again, these genes are implicated in transcriptional regulation (Hampsey and Reinberg, 1997).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Again", ",", "these", "genes", "are", "implicated", "in", "transcriptional", "regulation", "(", "Hampsey", "and", "Reinberg", ",", "1997", ")", "." ] } ]
PMC11088135	E qRT-PCR was conducted to analyze the mRNA expression of Bax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "qRT-PCR", "was", "conducted", "to", "analyze", "the", "mRNA", "expression", "of", "Bax", "." ] } ]
PMC5535901	Previous studies have reported that an increase in Ca positively regulates NF-κB activation and inhibition of calcium can block NF-κB activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "reported", "that", "an", "increase", "in", "Ca", "positively", "regulates", "NF-κB", "activation", "and", "inhibition", "of", "calcium", "can", "block", "NF-κB", "activity", "." ] } ]
PMC10093184	ADI-KAM-CC002-D, Enzo Life Sciences, Lausen, Switzerland; dil.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ADI-KAM-CC002-D", ",", "Enzo", "Life", "Sciences", ",", "Lausen", ",", "Switzerland", ";", "dil", "." ] } ]
PMC9429973	t-MDS had worse overall survival (OS) from MDS dx (HR 1.82, p=0.026).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "t-MDS", "had", "worse", "overall", "survival", "(", "OS", ")", "from", "MDS", "dx", "(", "HR", "1.82", ",", "p=0.026", ")", "." ] } ]
PMC9910796	For mouse mAbs for DNA, CD63 and PDI, the signal was amplified with bridging rabbit anti-mouse (RAM) IgG (Dako) followed by PAG10 or PAG15.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "mouse", "mAbs", "for", "DNA", ",", "CD63", "and", "PDI", ",", "the", "signal", "was", "amplified", "with", "bridging", "rabbit", "anti-mouse", "(", "RAM", ")", "IgG", "(", "Dako", ")", "followed", "by", "PAG10", "or", "PAG15", "." ] } ]
PMC9118379	The numbers of identified PSMs, variant peptides, and variant events obtained from SSe-cFDR and CMSe-cFDR are listed in Table S2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "numbers", "of", "identified", "PSMs", ",", "variant", "peptides", ",", "and", "variant", "events", "obtained", "from", "SSe-cFDR", "and", "CMSe-cFDR", "are", "listed", "in", "Table", "S2", "." ] } ]
PMC11269792	p < 0.05.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "." ] } ]
PMC11604768	All other chemicals were purchased from Sigma-Aldrich.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "other", "chemicals", "were", "purchased", "from", "Sigma-Aldrich", "." ] } ]
PMC11462673	Aberrant expression of the oncogene MYB in infant and adult T-cell leukemia/lymphoma cells leads to dysregulation of the c-MYB signaling pathway, laying the foundation for the malignancy of tumor cells [33–37].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aberrant", "expression", "of", "the", "oncogene", "MYB", "in", "infant", "and", "adult", "T-cell", "leukemia/lymphoma", "cells", "leads", "to", "dysregulation", "of", "the", "c-MYB", "signaling", "pathway", ",", "laying", "the", "foundation", "for", "the", "malignancy", "of", "tumor", "cells", "[", "33–37", "]", "." ] } ]
PMC11696576	However, shortening the carbon chain by one atom (GK419) led to considerable reduction of the inhibitory potency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "shortening", "the", "carbon", "chain", "by", "one", "atom", "(", "GK419", ")", "led", "to", "considerable", "reduction", "of", "the", "inhibitory", "potency", "." ] } ]
PMC10237474	no. P0711S for non-reducing format, P0710S for reducing format, NEB) in a total reaction volume of 10 μL at 50°C for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "P0711S", "for", "non-reducing", "format", ",", "P0710S", "for", "reducing", "format", ",", "NEB", ")", "in", "a", "total", "reaction", "volume", "of", "10", "μL", "at", "50", "°", "C", "for", "30", "min", "." ] } ]
PMC11531744	These findings suggested that GBP1P1 might be involved in the immune cell infiltration in OC. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggested", "that", "GBP1P1", "might", "be", "involved", "in", "the", "immune", "cell", "infiltration", "in", "OC", ".", "(" ] } ]
PMC11730320	Mature T cells are derived from multipotent hematopoietic stem cells in the bone marrow that undergo further maturation in the thymus (hence immature T cells are called thymocytes), where they rearrange T cell receptor (TCR) gene segments to form a diverse antigen recognition repertoire, and are finally subjected to negative selection against self-antigen recognition (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mature", "T", "cells", "are", "derived", "from", "multipotent", "hematopoietic", "stem", "cells", "in", "the", "bone", "marrow", "that", "undergo", "further", "maturation", "in", "the", "thymus", "(", "hence", "immature", "T", "cells", "are", "called", "thymocytes", ")", ",", "where", "they", "rearrange", "T", "cell", "receptor", "(", "TCR", ")", "gene", "segments", "to", "form", "a", "diverse", "antigen", "recognition", "repertoire", ",", "and", "are", "finally", "subjected", "to", "negative", "selection", "against", "self-antigen", "recognition", "(", "Fig.", "1", ")", "." ] } ]
PMC11699465	Some immunoregulatory genes are bound by TMEM199, such as IFNGR1, IRF1, KAT8, c-Jun, and Trim28 (Figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "immunoregulatory", "genes", "are", "bound", "by", "TMEM199", ",", "such", "as", "IFNGR1", ",", "IRF1", ",", "KAT8", ",", "c-Jun", ",", "and", "Trim28", "(", "Figure", "3D", ")", "." ] } ]
PMC9429973	Leukemic cells in BMMC samples were also iron sensitive and the effect became more evident upon combination with IBR or VNTX (p<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Leukemic", "cells", "in", "BMMC", "samples", "were", "also", "iron", "sensitive", "and", "the", "effect", "became", "more", "evident", "upon", "combination", "with", "IBR", "or", "VNTX", "(", "p<0.05", ")", "." ] } ]
PMC11727062	There has been a notable lack of research into the transcriptional effects of these monomers on genes linked to melanoma phenotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "has", "been", "a", "notable", "lack", "of", "research", "into", "the", "transcriptional", "effects", "of", "these", "monomers", "on", "genes", "linked", "to", "melanoma", "phenotypes", "." ] } ]
PMC9429973	He was reassessed after one month and troponin levels, PLT counts and ECG were normal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "He", "was", "reassessed", "after", "one", "month", "and", "troponin", "levels", ",", "PLT", "counts", "and", "ECG", "were", "normal", "." ] } ]
PMC9429973	Results: A total of 351 donors underwent hematological tumor genetic testing, including 223 males (63.53%) and 128 females (36.47%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "A", "total", "of", "351", "donors", "underwent", "hematological", "tumor", "genetic", "testing", ",", "including", "223", "males", "(", "63.53", "%", ")", "and", "128", "females", "(", "36.47", "%", ")", "." ] } ]
PMC10914904	This function is exemplified in cells overexpressing vtRNA 1-1, which directly binds to the p62 receptor, which is also known as the sequestosome 1 protein SQSTM1/p62 (Fig. 3) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "function", "is", "exemplified", "in", "cells", "overexpressing", "vtRNA", "1", "-", "1", ",", "which", "directly", "binds", "to", "the", "p62", "receptor", ",", "which", "is", "also", "known", "as", "the", "sequestosome", "1", "protein", "SQSTM1/p62", "(", "Fig.", "3", ")", "." ] } ]
PMC11487720	At 37℃, the cells underwent apoptosis (confocal microscopy; magnification: 1000X).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "37", "℃", ",", "the", "cells", "underwent", "apoptosis", "(", "confocal", "microscopy", ";", "magnification", ":", "1000X", ")", "." ] } ]
PMC11335267	Thus, a possible explanation for the lower body weight in Alx3-deficient mice relative to control animals fed with HFD is likely to be related to the decreased muscle mass observed in these animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "a", "possible", "explanation", "for", "the", "lower", "body", "weight", "in", "Alx3-deficient", "mice", "relative", "to", "control", "animals", "fed", "with", "HFD", "is", "likely", "to", "be", "related", "to", "the", "decreased", "muscle", "mass", "observed", "in", "these", "animals", "." ] } ]
PMC11791478	XB002 is an ADC developed to enhance the therapeutic efficacy of TF-targeting ADCs in oncology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XB002", "is", "an", "ADC", "developed", "to", "enhance", "the", "therapeutic", "efficacy", "of", "TF-targeting", "ADCs", "in", "oncology", "." ] } ]
PMC8584319	Recent studies have reported that the resistance to second-generation mTORC1/2 inhibitors is associated with ERK1/2 activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "reported", "that", "the", "resistance", "to", "second-generation", "mTORC1/2", "inhibitors", "is", "associated", "with", "ERK1/2", "activation", "." ] } ]
PMC11672142	In the presence of Fe2-sTf-(CO3)2, there was 64.5 ± 2.6 μM Fe in the medium, which matches the amount added to the medium accounting for the background Fe in the media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "presence", "of", "Fe2-sTf-(CO3)2", ",", "there", "was", "64.5", "±", "2.6", "μM", "Fe", "in", "the", "medium", ",", "which", "matches", "the", "amount", "added", "to", "the", "medium", "accounting", "for", "the", "background", "Fe", "in", "the", "media", "." ] } ]
PMC11790971	Each dot in the plots represents the result of one-fold of the 10-fold Monte Carlo cross-validation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "dot", "in", "the", "plots", "represents", "the", "result", "of", "one-fold", "of", "the", "10-fold", "Monte", "Carlo", "cross-validation", "." ] } ]
PMC10849234	Recently, differentiation of promyelocytic cells with Nutridoma was shown to increase the resultant NLCs’ ability to undergo phagocytosis, oxidative burst, and chemotaxis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "differentiation", "of", "promyelocytic", "cells", "with", "Nutridoma", "was", "shown", "to", "increase", "the", "resultant", "NLCs", "’", "ability", "to", "undergo", "phagocytosis", ",", "oxidative", "burst", ",", "and", "chemotaxis", "." ] } ]
PMC11746948	g GPX4 detected by immunoblots in A375 cells pre-treated with 2-BP for 24 h, followed by 12 h lysosome inhibitor BafA1 treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "GPX4", "detected", "by", "immunoblots", "in", "A375", "cells", "pre-treated", "with", "2-BP", "for", "24", "h", ",", "followed", "by", "12", "h", "lysosome", "inhibitor", "BafA1", "treatment", "." ] } ]
PMC8494202	Research on the role of N-glycan in tumors has recently attracted increasing attention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "on", "the", "role", "of", "N-glycan", "in", "tumors", "has", "recently", "attracted", "increasing", "attention", "." ] } ]
PMC10671321	The same direction of changes were observed for protein levels between the wt and the mutated proteins with a 4 fold increase in COS cells (Figure 2C,D) and a 54% decrease in muscle cells compared to WT proteins (Figure 2E,F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "direction", "of", "changes", "were", "observed", "for", "protein", "levels", "between", "the", "wt", "and", "the", "mutated", "proteins", "with", "a", "4", "fold", "increase", "in", "COS", "cells", "(", "Figure", "2C", ",", "D", ")", "and", "a", "54", "%", "decrease", "in", "muscle", "cells", "compared", "to", "WT", "proteins", "(", "Figure", "2E", ",", "F", ")", "." ] } ]
PMC10748106	All of them conserved the hydroxyl in C1, and others featured a methyl or a hydroxyl in C8, or both, and a hydroxyl in C6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "of", "them", "conserved", "the", "hydroxyl", "in", "C1", ",", "and", "others", "featured", "a", "methyl", "or", "a", "hydroxyl", "in", "C8", ",", "or", "both", ",", "and", "a", "hydroxyl", "in", "C6", "." ] } ]
PMC2614415	Overexpression of Aurora-A causes transformation in rodent fibroblasts and tumors in nude mice , consistent with the possibility that Aurora-A is an oncogene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "Aurora-A", "causes", "transformation", "in", "rodent", "fibroblasts", "and", "tumors", "in", "nude", "mice", ",", "consistent", "with", "the", "possibility", "that", "Aurora-A", "is", "an", "oncogene", "." ] } ]
PMC11590870	The chemical reagents used for the protein extraction, hydrolysis, cellular antioxidant assay and the FRAP reagents used were as follows: tris(hydroxymethyl)aminomethane hydrochloride (TRIS-HCl), NaCl, poly(vinylpolypyrrolidone) (PVPP), phenylmethanesulfonyl fluoride (PMSF), ethylenediaminetetraacetic acid (EDTA), ammonium sulfate, pepsin, HCl, NaHCO3, NaOH, pancreatin, dichlorodihydrofluorescein diacetate (DCFH-DA), 2,2′-azobis(2-methylpropionamidine)dihydrochloride (APPH), AcONa·3H2O, 2,4,6-Tri-(2-pyridyl)-s-triazine (TPTZ), Trolox and FeSO4·7H2O.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chemical", "reagents", "used", "for", "the", "protein", "extraction", ",", "hydrolysis", ",", "cellular", "antioxidant", "assay", "and", "the", "FRAP", "reagents", "used", "were", "as", "follows", ":", "tris(hydroxymethyl)aminomethane", "hydrochloride", "(", "TRIS-HCl", ")", ",", "NaCl", ",", "poly(vinylpolypyrrolidone", ")", "(", "PVPP", ")", ",", "phenylmethanesulfonyl", "fluoride", "(", "PMSF", ")", ",", "ethylenediaminetetraacetic", "acid", "(", "EDTA", ")", ",", "ammonium", "sulfate", ",", "pepsin", ",", "HCl", ",", "NaHCO3", ",", "NaOH", ",", "pancreatin", ",", "dichlorodihydrofluorescein", "diacetate", "(", "DCFH-DA", ")", ",", "2,2′-azobis(2-methylpropionamidine)dihydrochloride", "(", "APPH", ")", ",", "AcONa·3H2O", ",", "2,4,6-Tri-(2-pyridyl)-s-triazine", "(", "TPTZ", ")", ",", "Trolox", "and", "FeSO4·7H2O", "." ] } ]
PMC11727306	The observations in Figure 1, as measured by GFP expression, show that abrin toxin, which has binding affinity to galactose, reduces ribosomal activity and protein synthesis in kidney cells at low abrin concentrations and that milk, which contains galactose, interferes with this effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "observations", "in", "Figure", "1", ",", "as", "measured", "by", "GFP", "expression", ",", "show", "that", "abrin", "toxin", ",", "which", "has", "binding", "affinity", "to", "galactose", ",", "reduces", "ribosomal", "activity", "and", "protein", "synthesis", "in", "kidney", "cells", "at", "low", "abrin", "concentrations", "and", "that", "milk", ",", "which", "contains", "galactose", ",", "interferes", "with", "this", "effect", "." ] } ]

PMC11502327

Physical encapsulation and front-end carrier connection are two major strategies for drug delivery systems.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physical", "encapsulation", "and", "front-end", "carrier", "connection", "are", "two", "major", "strategies", "for", "drug", "delivery", "systems", "." ] } ]

PMC11718817

Importantly, nigericin treatment resulted in a slight increase in early macrophage infiltration into spheroids.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "nigericin", "treatment", "resulted", "in", "a", "slight", "increase", "in", "early", "macrophage", "infiltration", "into", "spheroids", "." ] } ]

PMC9428827

Charych et al. developed a modified IL-2, with a site-directed PEG attachment on the alpha surface of the molecule; the modified IL-2 (NKTR-214) also increased the CD8/Tregs ratio and has a higher half-life, which could be an advantage for treatment schedule but also a problem considering the toxic effects associated with the IL-2 molecule.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Charych", "et", "al.", "developed", "a", "modified", "IL-2", ",", "with", "a", "site-directed", "PEG", "attachment", "on", "the", "alpha", "surface", "of", "the", "molecule", ";", "the", "modified", "IL-2", "(", "NKTR-214", ")", "also", "increased", "the", "CD8/Tregs", "ratio", "and", "has", "a", "higher", "half-life", ",", "which", "could", "be", "an", "advantage", "for", "treatment", "schedule", "but", "also", "a", "problem", "considering", "the", "toxic", "effects", "associated", "with", "the", "IL-2", "molecule", "." ] } ]

PMC11585565

The medium was replaced with antibiotic-free Opti-MEM reduced serum medium (Gibco) supplemented with 40 mM Mg.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "was", "replaced", "with", "antibiotic-free", "Opti-MEM", "reduced", "serum", "medium", "(", "Gibco", ")", "supplemented", "with", "40", "mM", "Mg", "." ] } ]

PMC9429973

When subdivided according to IGHV status, the best ORR was 88% in IGHV mutated and 91% in IGHV unmutated patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "subdivided", "according", "to", "IGHV", "status", ",", "the", "best", "ORR", "was", "88", "%", "in", "IGHV", "mutated", "and", "91", "%", "in", "IGHV", "unmutated", "patients", "." ] } ]

PMC6835428

Indeed, its targeting resulted in enhanced cisplatin-induced apoptosis in OC spheroids .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "its", "targeting", "resulted", "in", "enhanced", "cisplatin-induced", "apoptosis", "in", "OC", "spheroids", "." ] } ]

PMC10154881

Dead cells were stained with fixable viability dye 506 (FVD506) (eBiosciences) according to the manufacturer's instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dead", "cells", "were", "stained", "with", "fixable", "viability", "dye", "506", "(", "FVD506", ")", "(", "eBiosciences", ")", "according", "to", "the", "manufacturer", "'s", "instructions", "." ] } ]

PMC11209164

This medium was supplemented with 1% penicillin–streptomycin (Gibco) and 10% fetal bovine serum (FBS), obtained from VWR (Mississauga, ON, Canada), to support optimal cell growth and maintenance.

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PMC10547921

However, its toxic side effects, such as neurotoxicity and gastrointestinal reactions, were also severe.

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PMC11678130

On the other hand, 1% SDS, selected as a positive control, caused hemorrhage, coagulation, and lysis immediately after its local application on the CAM, inducing a severe irritant effect.

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PMC11757131

Detection of triglyceride synthesis using the Applygen Technologies, Inc. triglyceride test kit. (

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PMC11617590

We also analyzed the effects of SFN on the expression of β‐catenin in the cytoplasm and nuclear fractions.

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PMC11637284

In contrast to most other mitochondrial OM-IM contact sites, the trypanosomal TAC is a permanent structure.

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PMC11594588

The clinical conditions most associated with venous thrombosis are generally related to the elements of Virchow’s triad .

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PMC7192625

Bait nodes are additionally labelled with the name of the gene whose promoter was targeted by the capture system.

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PMC3681794

In U2OS cells there was a significant reduction in apoptosis measured by morphological changes (p<0.05–001 2-tailed student t-test) (Figure 1B) and annexin V/7-AAD positivity (p<0.05–0.01 2-tailed student t-test) (Figure 1C), and a reduction in levels of cleaved caspase-3 and PARP on western blotting (Figure 1D) in hypoxia compared to normoxia.

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PMC11496728

Improving cell engineering for transient production can not only increase the expression level of difficult-to-express proteins, but also alter the host cell background to improve strong indicators of robust performance.

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PMC11696659

An association between abnormally shorter telomeres and increased risk or increased mortality in lung cancer had been reported .

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PMC11657695

Interestingly, reduction of EWS::ERG expression significantly reduces KCNA2 expression in 2 of the 3 cell lines tested (Figure S4B).Fig.

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PMC8073654

Overall, these accumulated results indicated that the extracts and components of the Z. cassumunar possess potential value in the prevention and treatment of various diseases related to inflammation.

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PMC11420784

3-MA treatment reduced the amounts of LC3-II in ΔpldA-infected 5637 cells and mouse bladders to levels similar to those in WT or ΔpldA+ infected (Figure 2C and 2D).

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PMC9429973

Aims: While multiple case reports document that these patients have hematological response to long term corticosteroid therapy, we hypothesized that inhibition of cyclooxygenase (COX) upstream of thromboxane synthase in the arachidonic acid pathway may be effective in this condition.

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PMC10926885

NDE1 was more abundant in SARC when monocytes and leukocyte‐mediated immunity were differentiating (Figure S7F).

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PMC11534035

Colony formation relative to siRNA control in A431 (C, D) and CAL39 cells (E, F).

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PMC9429973

Finally, we assessed the applicability of using commonly available EDTA tubes and RNA stabilizing PAXgene tubes for bone marrow sampling, RNA isolation and whole transcriptome sequencing.

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PMC11066331

Finally, PLS-DA with 100 % accuracy (Cl = 94.7–100 %).

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PMC11759543

∗∗∗ and ###p < 0.001, ∗∗p < 0.01.

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PMC7553912

Kidney stone disease, also known as urolithiasis, is a common urologic disorder and is associated with the development of chronic kidney disease (CKD) and end-stage renal disease.

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PMC10048572

Moreover, time point analysis is unable to provide information concerning clonal evolution of tumor cells, that could explain the resistance of the tumor to chemotherapy and targeted therapy .

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PMC11665584

Furthermore, PITX1 skin healed significantly faster than control skin via increased keratinocyte activation and migration and a tunable inflammatory environment.

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PMC11437637

Shake and mix thoroughly, centrifuge at 1100rpm for 5 minutes, and discard the supernatant.

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PMC9424261

The liver is the sixth most common site of primary cancers, but liver cancer is the third leading cause of cancer-related death globally .

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PMC11588008

Remove the cell culture medium and wash the cells once with PBS.

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PMC11545737

After entering the cell, S. flexneri lyses the vacuole and reaches the cell cytosol .

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PMC9429973

This WGS cohort comprised 399 CLL, 155 diffuse large B-cell lymphomas (DLBCL), 110 Burkitt lymphomas (BL), 61 mantle cell lymphomas (MCL), and 37 follicular lymphomas (FL).

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PMC9786247

In brief, C. burnetii aliquots were prepared with 1 × 10 bacterial cells per ml NaCl solution, stored at −80 °C, thawed at ambient temperature and resuspended thoroughly for at least 1 min to separate bacterial agglutination immediately prior to inoculation .

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PMC11659734

Visible precipitate was observed at 60 μM and above.

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PMC10955424

According to our previous finding, crizotinib also inhibits JAK2 .

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PMC11633763

Additionally, USP22 knockdown shortened the half‐life of β‐catenin, and MG132 treatment blocked the effects of USP22 knockdown or overexpression on β‐catenin.

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PMC11389534

Specialised intestinal epithelial cells, such as Paneth cells, are capable of secreting a variety of immune mediators that help regulate host immune responses.

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PMC10589262

Several studies on GISTs have assumed that MT-KIT localized in the PM delivers downstream signaling .

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PMC11448304

In this article, a lung adenocarcinoma cell line, radioresistant A549 (RA549), was generated by exposure to a series of irradiation.

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PMC10154097

Another study indicated that miR-381 inhibited epithelial ovarian cancer cell behaviors by suppressing YY1 which corroborates our findings .

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PMC11597291

The reaction mixture was bath-sonicated in an ice-bath for 30 min and then gently stirred for 24 h at ambient temperature in the dark.

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PMC9429973

Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are recurrently identified, actionable driver events in adult patients with AML.

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PMC11742670

Conversely, features such as SdNH, StCH, SsSH, StN, SssS, -0.10 < mZagreb2 < = 0.41, -0.42 < piPC8 < = 0.20, SdsCH, -0.11 < Sm < = 0.44, -0.41 < Xc-6d < = 0.23, -0.13 < TopoPSA < = 0.24, -1.45 < SRW09 < = 0.60, -0.63 < TSRW10 < = 0.01, SsCl, and SsI exhibit negative effects on IC50 predictions.

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PMC5311252

The top scoring network in this analysis was centered on E2F1 (Supplementary Figure 4d), further supporting a role of oncomotif-miRNAs in regulation of tumor cell proliferation.

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PMC9429973

Inclusion/exclusion criteria, and the design and schedule of the intense immune and safety monitoring will be presented.

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PMC6642070

Lactate production in A-204 cells exposed to atorvastatin (Atr), pitavastatin (Pit), simvastatin (Sim), rosuvastatin (Ros), and lovastatin (Lov) at 10 μM for 48 h (n = 3). (

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PMC10452486

Evidently, group (iii) may represent a neo-HLA class which may be the progenitors of other HLA classes of proto-HLA.

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PMC10900886

EV-D68 circulation was limited during the pandemic, partly due to COVID-19 measures, but EV-D68-associated severe respiratory illnesses have been rising in several countries since 2021 and 2022 due to easing of COVID-19 measures (6, 7).

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PMC11682525

Hydrogen peroxide was used at concentrations ranging from 200 to 2000 micromolar, and it was diluted in a complete medium ( 15 ).

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PMC9635307

Differences were considered to be statistically significant when p value < 0.05.

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PMC11240571

.

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PMC11357960

Recent studies have found that, during anti-PD-1 immunotherapy, only a small fraction of tumor-infiltrating lymphocytes can specifically recognize and attack cancer cells to achieve therapeutic effects (20, 21).

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PMC11765243

Intracellular signals were determined as described in detail in .

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PMC11740207

Correlation and network analyses will further uncover key genes and interactions driving the unique properties of VSELSCs and VSLSLCs.

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PMC9429973

Two patients had a fatal outcome due to the development of pneumonia and subsequent sepsis.

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PMC7840816

The sequences corresponding to the siRNA of SOX9 were 5′-GCAGCGACGUCAUCUCCAAdTdT-3′ (sense) and 5′-dTdTCGUCGCUGCAGUAGAGGUU-3′ (antisense).

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PMC5417661

Control cells were treated with the vehicle only.

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PMC11422497

TUNEL assay was performed to determine the cell apoptosis rate in Xenograft tumors.

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PMC10198699

For example, the fact that one may not trade in cannabis does not mean that one cannot own cannabis.

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PMC9100622

One of the polymorphisms observed in EwS patients was shown to increase the length of a GGAA microsatellite repeat motif, thus inducing increased binding of EWSR1-FLI1 and, consequently, increased EGR2 expression .

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PMC11803149

gRNA was mixed with Cas9 and incubated for 10 min at RT.

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PMC11665584

The activated keratinocyte genes Krt6a, Krt16, and Krt17 all had significant enrichment of both PITX1 and H3K4me3 at the TSS, correlating with the increased transcription of these genes (Figure 3B and Supplemental Figure 6B).

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PMC11790599

In contrast to TSL, which induces catastrophic macropinocytosis (methuosis) leading to cell death in ER+, HER2+/EGFR+ breast cancer cell lines, no cytoplasmic vacuoles were observed in NTSL-treated cells (data not shown).

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PMC7334607

Again, these genes are implicated in transcriptional regulation (Hampsey and Reinberg, 1997).

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PMC11088135

E qRT-PCR was conducted to analyze the mRNA expression of Bax.

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PMC5535901

Previous studies have reported that an increase in Ca positively regulates NF-κB activation and inhibition of calcium can block NF-κB activity .

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PMC10093184

ADI-KAM-CC002-D, Enzo Life Sciences, Lausen, Switzerland; dil.

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PMC9429973

t-MDS had worse overall survival (OS) from MDS dx (HR 1.82, p=0.026).

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PMC9910796

For mouse mAbs for DNA, CD63 and PDI, the signal was amplified with bridging rabbit anti-mouse (RAM) IgG (Dako) followed by PAG10 or PAG15.

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PMC9118379

The numbers of identified PSMs, variant peptides, and variant events obtained from SSe-cFDR and CMSe-cFDR are listed in Table S2.

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PMC11269792

p < 0.05.

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PMC11604768

All other chemicals were purchased from Sigma-Aldrich.

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PMC11462673

Aberrant expression of the oncogene MYB in infant and adult T-cell leukemia/lymphoma cells leads to dysregulation of the c-MYB signaling pathway, laying the foundation for the malignancy of tumor cells [33–37].

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PMC11696576

However, shortening the carbon chain by one atom (GK419) led to considerable reduction of the inhibitory potency.

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PMC10237474

no. P0711S for non-reducing format, P0710S for reducing format, NEB) in a total reaction volume of 10 μL at 50°C for 30 min.

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PMC11531744

These findings suggested that GBP1P1 might be involved in the immune cell infiltration in OC. (

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PMC11730320

Mature T cells are derived from multipotent hematopoietic stem cells in the bone marrow that undergo further maturation in the thymus (hence immature T cells are called thymocytes), where they rearrange T cell receptor (TCR) gene segments to form a diverse antigen recognition repertoire, and are finally subjected to negative selection against self-antigen recognition (Fig. 1).

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PMC11699465

Some immunoregulatory genes are bound by TMEM199, such as IFNGR1, IRF1, KAT8, c-Jun, and Trim28 (Figure 3D).

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PMC9429973

Leukemic cells in BMMC samples were also iron sensitive and the effect became more evident upon combination with IBR or VNTX (p<0.05).

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PMC11727062

There has been a notable lack of research into the transcriptional effects of these monomers on genes linked to melanoma phenotypes.

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PMC9429973

He was reassessed after one month and troponin levels, PLT counts and ECG were normal.

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PMC9429973

Results: A total of 351 donors underwent hematological tumor genetic testing, including 223 males (63.53%) and 128 females (36.47%).

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PMC10914904

This function is exemplified in cells overexpressing vtRNA 1-1, which directly binds to the p62 receptor, which is also known as the sequestosome 1 protein SQSTM1/p62 (Fig. 3) .

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PMC11487720

At 37℃, the cells underwent apoptosis (confocal microscopy; magnification: 1000X).

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PMC11335267

Thus, a possible explanation for the lower body weight in Alx3-deficient mice relative to control animals fed with HFD is likely to be related to the decreased muscle mass observed in these animals.

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PMC11791478

XB002 is an ADC developed to enhance the therapeutic efficacy of TF-targeting ADCs in oncology.

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PMC8584319

Recent studies have reported that the resistance to second-generation mTORC1/2 inhibitors is associated with ERK1/2 activation .

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PMC11672142

In the presence of Fe2-sTf-(CO3)2, there was 64.5 ± 2.6 μM Fe in the medium, which matches the amount added to the medium accounting for the background Fe in the media.

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PMC11790971

Each dot in the plots represents the result of one-fold of the 10-fold Monte Carlo cross-validation.

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PMC10849234

Recently, differentiation of promyelocytic cells with Nutridoma was shown to increase the resultant NLCs’ ability to undergo phagocytosis, oxidative burst, and chemotaxis .

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PMC11746948

g GPX4 detected by immunoblots in A375 cells pre-treated with 2-BP for 24 h, followed by 12 h lysosome inhibitor BafA1 treatment.

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PMC8494202

Research on the role of N-glycan in tumors has recently attracted increasing attention.

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PMC10671321

The same direction of changes were observed for protein levels between the wt and the mutated proteins with a 4 fold increase in COS cells (Figure 2C,D) and a 54% decrease in muscle cells compared to WT proteins (Figure 2E,F).

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PMC10748106

All of them conserved the hydroxyl in C1, and others featured a methyl or a hydroxyl in C8, or both, and a hydroxyl in C6.

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PMC2614415

Overexpression of Aurora-A causes transformation in rodent fibroblasts and tumors in nude mice , consistent with the possibility that Aurora-A is an oncogene.

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PMC11590870

The chemical reagents used for the protein extraction, hydrolysis, cellular antioxidant assay and the FRAP reagents used were as follows: tris(hydroxymethyl)aminomethane hydrochloride (TRIS-HCl), NaCl, poly(vinylpolypyrrolidone) (PVPP), phenylmethanesulfonyl fluoride (PMSF), ethylenediaminetetraacetic acid (EDTA), ammonium sulfate, pepsin, HCl, NaHCO3, NaOH, pancreatin, dichlorodihydrofluorescein diacetate (DCFH-DA), 2,2′-azobis(2-methylpropionamidine)dihydrochloride (APPH), AcONa·3H2O, 2,4,6-Tri-(2-pyridyl)-s-triazine (TPTZ), Trolox and FeSO4·7H2O.

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PMC11727306

The observations in Figure 1, as measured by GFP expression, show that abrin toxin, which has binding affinity to galactose, reduces ribosomal activity and protein synthesis in kidney cells at low abrin concentrations and that milk, which contains galactose, interferes with this effect.

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