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OTAR3088
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BioData-CellLine_annotated

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PMC11593031
A reverse FISH result on normal mouse chromosomes is depicted in Figure S1.
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PMC8806312
Student’s t-test for independent samples was carried out to assess the notable differences between both groups.
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PMC11770746
The stability of the Pt(IV) compounds was measured in RPMI medium, at pH = 7 and 37 °C, by monitoring the peak area of the prodrugs as a function of time.
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PMC10656496
Red dashed lines indicate IC50 for each cell line.
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PMC11525028
Venn diagram showing the intersection between downregulated genes (fold change <0.75, adjusted p value <0.05) and peaks (fold change <0.75, adjusted p value <0.05) of NAT10-KO cells compared to control cells for the 143B and HOS cell lines. (
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PMC11342785
All synMAP TPPP-IDR chimeras were tested at the same concentration.
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PMC11252033
The A2780S and A2780R were transfected with 100 nM specific siRNA (IDT, Leuven, Belgium) against human CryZ by means of jetPRIME (Polyplus, Illkirch, France) according to the instruction manual.
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PMC4360730
Annotating metadata properties to these ontologies will standardize our representation of the objectives of a given experiment and relate that experiment to other assays with similar aims across various projects.
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PMC10092581
Fluorescence intensity was estimated using a plate reader (Tecan Infinite M200 PRO, Männedorf, Switzerland) at 490 (excitation) and 590 nm (emission).
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PMC11095939
Data are presented as means ± SEM.
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PMC11470999
Additionally, von Hippel‒Lindau (VHL) is the endogenous E3 ligase for CIP2A, and PF enhances the interaction between VHL and CIP2A, promoting the ubiquitin‒proteasome degradation of CIP2A, thereby inhibiting melanoma growth and metastasis.
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PMC8973725
ZNF281 has been demonstrated to play a crucial role in controlling cellular stemness and EMT by inducing EMT and regulating EMT-associated gene expression in colorectal cancer .
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PMC11746948
Two additional rounds of methanol-chloroform-H2O precipitations were performed on the samples as described above, and then dissolved in 100 μl of lysis buffer.
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PMC11190538
IC50 was determined by SPSS Incprobit analysis (IBM Corp., Armonk, NY, USA).
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PMC11727306
In those cells abrin appeared to promote ribosomal activity, as demonstrated by the secretion of cytokines in pre-stimulated T-cells, where production of newly synthesized proteins would be necessary.
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PMC11257203
The effect of indomethacin and curcumin (27 μg/mL) on lipid peroxidation was observed in human peripheral blood lymphocytes.
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PMC11738017
At time 0, the cells were seeded at 1 × 10 cells per mL with or without GSI at a dose of 200 nM. The supernatant was collected at the respective time points and the sBCMA levels analyzed by enzyme-linked immunosorbent assay.
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PMC10291556
Phagocytosis was evaluated using flow cytometry (BD FACSVerse), and data were analyzed with FCS Express 7 (DeNovo software; Glendale, CA).
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PMC10213199
The double-stranded PCR products from the previous step were denatured and circularized using splint oligo sequences to obtain the final library.
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PMC6892818
Equal loading for human epithelial cell lysate was confirmed by CK18 detection (see Methods).
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PMC11394386
Further examination of HOTAIR expression in CC cell lines showed consistent results, with HOTAIR notably overexpressed in the HeLa cell line compared to non-tumor cell lines (Figure 1C).
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PMC11747467
The differences in ERBB2 mRNA expression across different types of CNV were further analyzed.
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PMC10713411
Meanwhile, the downregulation of TRIB3 promoted the apoptosis and autophagy process and decreased the expression levels of proteins related to DNA damage repair.
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PMC5963610
Interestingly, combination treatment increases tumor infiltrating CD4T, CD8T and NK-cells.
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PMC11087301
Previous studies reported that EMT can be induced via a modulatory network organized through a variety of pathways specifically transforming growth factor beta 1 (TGF-β1) as a crucial driver .
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PMC10577955
Small nuclear RNAU6 (RNU6B; Applied Biosystems Inc.) was used for normalization.
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PMC11502443
No significant differences in Emax were observed for AKT, ERK1/2 or CREB phosphorylation.
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PMC11637820
Pathogens-associated molecular patterns (PAMPs) are microbial structures and DNA which are crucial for survival and virulence and are recognized by evolutionarily conserved pattern recognition receptors (PRRs) in eukaryotic cells, thereby activating innate immune responses.
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PMC11335267
Previous research shows that deficiency of the transcription factor Alx3 alters pancreatic islet-dependent glucose homeostasis.
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PMC11678368
The SI values for the compounds were calculated from the data presented in Table S7 in the Supplementary Materials.
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PMC11794847
Meanwhile, the immunotherapy responders quantified by TIDE analysis has a higher HVEM level (Fig. 1E); the patients with high HVEM level have a higher level of immune dysfunction (Fig. 1F).
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PMC9429973
Median duration of 3L therapy was 17.0 months.
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PMC9429973
Methods: Patients must have failed at least one prior induction course of therapy or have a relapse or have a persistent MRD-positive disease after consolidation treatment.
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PMC9429973
Prevalence of hemoglobinopathy disorders in Saudi Arabia is high.
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PMC11768927
Similarly, Alajez et al. utilized a vascular disrupting agent, ZD6126, in combination with VSV-MΔ51, which resulted in increased VSV-mediated oncolysis in vitro and improved survival in an in vivo mouse model with hypopharyngeal squamous cell carcinoma xenografts.
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PMC11637284
Note that the alignment contains some gaps due to small insertions and deletions relative to the T. brucei sequence (S4 Fig).
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PMC9429973
The study is ongoing, and additional safety and efficacy data will be provided at the meeting.
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PMC11310713
This fundamental difference may contribute to the disparity in potential side effects between the 2 methods.
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PMC11365427
Schematic of the DARTS-proteomics. (
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PMC11319300
Interactions at higher resolutions can be predicted using the HiP-HoP polymer simulation scheme (Rico et al., 2022).
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PMC9412887
Researchers proposed that the optimal size of nanoparticles is approximately 100 nm for long blood circulation and tumor accumulation .
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PMC11412721
Clones were obtained by seeding cells at low density (1 cell/5 wells) in 96-well plates, expanded, then subdivided into two parts, half for storage in liquid nitrogen and half for ACKR4 genotyping by Sanger DNA sequencing (see Supplementary file 3 for primer sequences).
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PMC2193049
Using this approach, we obtained strong evidence in favor of the involvement of the proteasome in the final proteolytic step leading to the generation of the antigenic peptide MAGE-3271–279, notwithstanding the possibility that distinct cellular proteases may be involved at other stages in the processing of the MAGE-3 protein into precursor peptide fragments.
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PMC11543853
The data for single-particle analysis were collected using the same microscope and camera as with the cryo-ET data.
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PMC10999934
GO analysis. (
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PMC11761919
The Fiber2-specific IgG levels in the groups orally administered with Micro-E/Fiber2-inulin and Micro-E/Fiber2-PINs were significantly higher than those in E. faecalis/Fiber2 and Micro-E/Fiber2 groups (p < 0.01).
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PMC11365983
CNS phenotypes include cerebellar vermis hypoplasia, posterior fossa enlargement, and lateral ventricular dilation: example from an individual with a missense mutation (p.S82T).
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PMC10218459
In the case of melanoma, even in vivo studies have been carried out with a combination of CPP and chemotherapy, and they showed a pronounced anti-tumoral effect in reducing tumor size .
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PMC11695546
It is imperative that we develop a successful strategy to combat H. pylori to prevent possible associated conditions (Yahya et al. 2022; Qanash et al. 2023a).
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PMC10994876
Following 48 h, the Mock and NT groups displayed a VCD of 3.25 × 10 ± 0.29 and 4.55 × 10 ± 0.06 cells/ml, respectively, whereas the OE-YAP5SA group exhibited a significantly higher VCD of 9.05 × 10 ± 0.21 cells/ml.
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PMC11758416
Assays performed without anti-CD3 loading on the L cells resulted in significantly less killing of target L cells, indicating that the cell death is induced by TCR ligation.
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PMC8873393
5Spatial-temporal transcriptional dynamics of long noncoding RNAs upon UV exposure.
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PMC10114490
4PD diHLC-T perform hepatocyte functions.
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PMC11787355
ACT.
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PMC11680578
.
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PMC11711127
Mechanisms of T cell resistance are widely targeted to either boost or reduce immune responses in the context of cancer or autoimmunity, respectively.
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PMC11787355
92% of APVAC1-vaccinated patients developed MHC class I (MHCI)-dependent immunogenicity.
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PMC11013014
M.p.
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PMC10993311
We found statistically significant differences in TC and TG between the two groups but not in the other parameters, probably because the pregnant women in the two groups investigated were healthy and had a similar and adequate pre-pregnancy BMI.
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PMC11549062
In addition, acetylated LDL/cholesterol‐loaded lysosomes could be transported from macrophages into VSMCs .
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PMC5925824
Panned phages were screened for the presence of scFv that blocked the interaction of PD-L1 with both PD-1 and CD80.
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PMC9429973
B-CLL cells secrete high levels of major angiogenic factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hypoxia inducible factor 1 alpha (HIF1α).
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PMC10747160
Our initial hypothesis to explain this phenomenon was that the aforementioned cross-linking capabilities of Griffithsin could tether multiple viruses together, thereby allowing a single DC-SIGN receptor to capture more than one virion .
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PMC9429973
Image: Summary/Conclusion: ASCT before Ly-apheresis may result in a higher prevalence of “exhausted” T-cells.
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PMC2777936
Total cellular RNA was isolated using TriReagent (Molecular Research Center, OH) and cDNA was synthesized from 1 μg of total RNA according to the manufacturer's instructions (SABioscience).
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PMC11407042
Shake the dish gently and observe under the inverted microscope to ensure cells have spread evenly.k.
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PMC6642070
Total and phosphorylated MDM2 (Ser166) protein levels with fluvastatin (10 μΜ) treatment in A-204 cells for 48 h. (c) Cytosolic extract of A-204 cells treated with fluvastatin (10 μΜ) for 48 h were immunoprecipitated (IP) with control IgG or anti-p53 antibody.
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PMC11673128
The highest rates of phagocytosis were evident in those conditions (i.e., AS4, H3122, CLB-Ga-LR1000) where the long-term administration of TKIs was employed, in accordance with the upregulation of CD47 found after at least one week of TKIs incubation (Figure 3A–C).
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PMC11684821
In 5 of 6 donors, one of the top 10 responding clonotypes expanded after priming with C1R-MR1*01 targets used TRAJ42 paired with 5 different TRAV genes to give the same CAXYGGSQGNLIF motif, with X representing 3–5 amino acids, and the CDR3-α being 15–17 amino acids in length (Supplemental Figure 5, A and B).
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PMC11723947
The research carried out in this study complies with all relevant ethical and legal rules.
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PMC9429973
Methods: 14 acute lymphoblastic leukemia (ALL) patients (2 T-ALL and 12 B-ALL, 9 males and 5 females) who received CD7 or CD19 CAR-T therapy bridging allogeneic hematopoietic stem cell transplantation(allo-HSCT) were enrolled from September 2019 to January 2022 in Beijing Lu Daopei hospital.
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PMC11519788
Besides, Nanog is also a direct STAT3 target gene to contribute to self-renewal of liver CSC 45.
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PMC11509278
This NAFLD pathway is induced by dietary cholesterol through activation of the ligand-activated nuclear receptor liver X receptor , which is consistent with the downregulation of the metabolite cholesterol in this study.
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PMC9429973
The Janus Kinase (JAK) 1/2 inhibitor ruxolitinib (RUX) suppresses cytotoxic T cell activation and inhibits production of interferon gamma and tumor necrosis factor alpha in models of graft-versus-host disease.
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PMC11612794
DNA was stained with DAPI.
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PMC3888431
This approach combines the advantages of reference-based and de novo assemblies within one tool.
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PMC10705095
Kaplan–Meier survival analysis revealed that patients with lung adenocarcinoma with high HBQ1 expression had significant differences in OS and FP.
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PMC9599726
Next, 5% sulfosalicylic acid (SSA) was added to the supernatant to precipitate and remove proteins from the sample and to protect GSH oxidation.
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PMC10729469
= 1.5 μg/μL).
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PMC8068766
The Kaplan Meier plots were generated for selected DEGs in HCC patients in liver cancer RNA-seq dataset by considering Overall Survival data.
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PMC7823217
The co-culture models can be seeded both following cancer MCTS formation or simultaneously with tumor cells in non‐adherent conditions .
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PMC10772747
The cell pellet was resuspended in a solution of PI (50 μg/mL in PBS containing 1% Triton X-100 (Merck)) and DNase-free RNase A (20 μg/mL), and incubated for 30 min at 37°C.
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PMC11194678
Representative DIC images of STAU1 droplets with the increasing amounts of MTOR 5′UTR RNA.
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PMC11806182
Among these, miR-142 (up-regulated in PCOS), miR-424, and miR-331 (both down-regulated in PCOS) were identified as protective factors.
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PMC10994876
Error bars represent the standard deviation (S.D) Apoptosis analysis of OE-YAP5SA EPO-CHO compared to control cells: We examined the cells using Annexin V-PE and 7-AAD staining.
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PMC8316344
Labile iron was measured by Iron Assay Kit before and after TRIB2 was knocked out in Bel-7404 cells with siRNA-mediated knockdown for indicated iron regulators.
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PMC11488203
Data represent the mean ± s.d.
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PMC9429973
The primary endpoint was safety with efficacy secondary.
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PMC10969097
This protein is linked to resistance to anthracyclines, vinca alkaloids, actinomycin D, Taxol (e.g., paclitaxel) and other substances .
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PMC11453018
In the non-ES cell line pool, we included diverse cancer cell lines such as breast carcinoma (T-47D), rhabdomyosarcoma (A204), synovial sarcoma (Fuji), and osteosarcoma (HOS, U2-OS).
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PMC11488203
Expression of exosome-specific proteins like the tetraspanins CD9, CD63, and CD81, and TSG101 as an integral protein of the ESCRT (endosomal sorting complex required for transport) machinery were detectable in all MSC-derived exosome preparations (Fig. 1A; suppl.
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PMC11060216
To quench endogenous peroxidase activity, the sections were blocked with 3% hydrogen peroxide at room temperature for 15 min.
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PMC9370419
Cell survival rate curves and IC50s were calculated using GraphPad Prism.
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PMC11400680
In this study, we calculate mAP50 which uses IoU (0.5 or 50%), and mAP75 which uses IoU (0.75 or 75%).
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PMC9429973
None of the study patients experienced grade IV mucositis.
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PMC7189327
In the present study, we performed an integrated bioinformatics analysis using five microarray datasets about BCC.
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PMC11543885
Prepare and coat the 6-well plate as described above.
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PMC11802929
Combining all PG-TCR groups, we observed that persisting cells at the post-acute timepoint showed higher expression of genes that were associated with long-lived memory signatures (such as CCR7, IL7R, HLA-DR, MKI67, etc) (Supplementary Fig. 9f), in agreement with previous studies.
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PMC11155445
Experimental electrochemical study showed that the compounds (53 and 54) undergo irreversible redox potential processes (Fig. 9).
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PMC11747467
For locally advanced and metastatic bladder cancer, current treatment options are limited.
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