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OTAR3088
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BioData-CellLine_annotated

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PMC10547921
If these agonists can be further optimized, they have the potential to revolutionize the field of immunotherapy.
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PMC9429973
No significant difference was found in the ORR and CR rates according to pts treated with CT vs. NT of 67% vs. 69% and 47% vs. 55%, respectively.
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PMC10747160
To prepare the dilutions, 100 mg of mannan was dissolved in 40 mL of ultrapure water to create a 2.5 mg mL stock solution of mannan.
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PMC11092382
The plasma clearance rate was 9.15 ± 2.58 mL/min, with 32.0% ± 7.0% of the excreted sophocarpine remaining unchanged in the urine within 24 h, indicating a renal clearance fraction of 0.32 ± 0.07.
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PMC10440586
The correlation between CD99 expression and hypoxia-related metabolic pathways in the TCGA datasets. (
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PMC10538569
Briefly, TZM.bl cells are derived from HeLa cells that have been transduced to express HIV-1 receptors and co-receptors CD4, CCR5, and CXCR4, respectively (34).
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PMC9429973
The 15-year cumulative risk of MDS/AML was 4.6% [2.8;6.3] for patients (Fig. 1c) and the median overall survival following secondary MDS/AML was only 7 months.
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PMC9429973
Descriptive statistics, frequency, or percentage were used to analyze outcomes.
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PMC4355729
The activation of the PI3K/AKT pathway has been reported to induce differentiated cells to transform into highly tumorigenic and cancer stem-like cells44.
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PMC11774112
Tumor growth was significantly less inhibited in the Blank-PHRD group than the PHRD-DTIC, PHRD-miRNA and Co-PHRD groups.
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PMC11185260
Significantly higher levels of SMARCB1 mRNA were detected in BT-12 cells treated with the scL-SMARCB1 nanocomplex across all time points, but not in BT-12 cells treated with scL-vec, than in untreated cells.
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PMC10582049
A set of canonical cell markers were used to assign all detected cell clusters to 10 cell populations.
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PMC11087766
Import of GFPmut1 is lost if a surface-exposed phenylalanine (F99) is mutated and partially lost if a nearby surface-exposed methionine (M153) is mutated (10), suggesting the signals that target proteins to the nucleus may be encoded in amino acids distant in sequence but located on the same surface in the folded protein.
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PMC11371747
Most culture conditions are described in the papers cited in the legend of Table 1.
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PMC11659921
To assess the immune scores associated with angiogenesis and stemness‐related genes in OV, we employed immunedeconv, an R package that incorporates six sophisticated algorithms: TIMER, xCell, MCP‐counter, CIBERSORT, EPIC, and quanTIseq.
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PMC8557138
Yan et al. used HeLa cell-laden silk fibroin hydrogel implants in CAM models to show the induction of apoptosis mediated by conformational changes in the 3D structure of the hydrogel.
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PMC9777812
Hawke et al. reported that skeletal muscle regeneration of CDKN1A-/- mouse was significantly enhanced compared with wild type muscle .
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PMC11757230
Representative dot plots and the frequency of apoptotic cells under different culture conditions are shown for (a) CLC, (b) CLK, (c) Ema, (d) CL-1, (e) UL-1, and (f) GL-1.
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PMC4355729
Thirteen of patients were male and the rest were female.
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PMC11621493
B, C) (Lyso)phospholipase activity of partially purified murine PLA2G4D and the mS370A mutant in the absence and presence of 1 mM CaCl2.
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PMC11787651
A and B, volcano plots illustrating differentially expressed histone PTM marks for entinostat–control samples observed using the 10-min and 55-min methods.
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PMC11680982
The ratio of firefly to Renilla luciferase activity was used to assess relative luciferase activity.
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PMC10818573
Nevertheless, no mention of A-431 cells containing EBV fragments within their genes has been reported in the published literature to date.
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PMC11682224
In certain tumors, the CHD1L gene may undergo abnormalities through mechanisms such as gene amplification and mutations, leading to abnormally high levels of CHD1L protein expression.
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PMC11139449
This study was performed to develop a cost-effective protocol using the CRISPR-Cas9 system combined with the HITI strategy for simultaneous CASP8AP2 gene deletion/insertion in CHO cells and to assess its impact on cell viability and protein expression.
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PMC11085211
These data may fuel further studies searching for novel treatments in GIST, including additional strategies that augment the existing treatments, resulting in better patient outcomes.
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PMC11640555
In this context, VEGF and CD34 remain the key molecules thought to drive ECs growth, migration, vessel dilation, and permeability .
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PMC10538569
To determine transgene expression, 3 X 10 mock-, pRRL-GPI-scFv X5 or AB65-2A-GFP-transduced human primary CD4 T cells were stained with rabbit anti-HA tag antibody at 4C for 40 min.
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PMC9429973
Results: We identified in the CAR-T cell transfusion bags 5 distinct CAR-T morphological sub groups prior to transfusion: regular, activated, apoptotic, multinucleated and cells in mitosis (Fig. 1A).
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PMC11777207
P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ns, P > 0.05.
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PMC10123657
Briefly, cells were placed in 200 μL of PBS 1× with 2% FBS on ice and anti Sca-1 was added, mixed, and incubated for 30 min.
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PMC2118063
This multistep process of differentiation is governed by an interlocking chain of transcription factors, some of which function as “master regulators” of developmental decision points, each with its own set of target genes (2–4).
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PMC9429973
Of note, only 16.0% of the patients were vaccinated with 2 or more doses of vaccine at the onset of COVID-19.
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PMC11747949
Changes in percentage of surface protein expression of these markers: CCR2, CAIX, VEGFR, PD‐L1, and CD44, when 143B cells are gown in mono‐culture (brown circles) or when they are exposed to PBMC cells in a transwell assay (purple squares), either under normoxia (empty shapes) or hypoxia (filled shapes). (
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PMC9429973
The algorithm also provides an accurate prediction of disease severity, enabling ophthalmology services to triage patients so that timely care is provided to those in greatest need.
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PMC9429973
Thereof, 7 reported PROs inconsistently.
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PMC11718817
Methods going beyond sheer size measurement and infiltration counts are also employed by other groups working on tumor spheroids.
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PMC11742670
Therefore, the FRS has been employed for feature selection in this phase.
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PMC11783017
The main reasons for this include the high heterogeneity, invasiveness, and metastatic nature of OS and the limited effectiveness of conventional radiotherapy and chemotherapy interventions for OS .
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PMC11740573
Therefore, future studies should also consider the effect of live bacteria on the inflammatory response in the presence of calcitriol, as this will better reflect the dynamics of changes occurring in vivo.
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PMC11767793
Besides the lab-made Au-PEI@NIST and Au-PEG-COOH@NIST, commercially available Au-PEI@Cs from Nanopartz Inc. (Loveland, CO, USA) and nanoComposix (San Diego, CA, USA) and Au-PEG-COOH@C (Nanopartz Inc.) were also obtained for comparison purposes in terms of the physicochemical properties, colloidal stability, and cytotoxicity.
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PMC11297139
Each dot represents the ARID1A concentration from a unique cell.
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PMC11119602
Its calcium-dependent activity results in the synthesis of glutamyl-lysyl isopeptide cross-links and/or a range of post-translational modifications of proteins, including deamidation and amine incorporation into reactive glutaminyl side-chains of protein substrates .
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PMC11737091
We analysed its expression patterns, prognostic and diagnostic value, and potential mechanisms.
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PMC11464982
Only food enzymes included in the European Union (EU) Community list may be placed on the market as such and used in foods, in accordance with the specifications and conditions of use provided for in Article 7(2) of Regulation (EC) No 1332/20081 on food enzymes.
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PMC10391797
THP-1 co-cultured with CAR-T cells and a minute dose of HDACi (VPA 0.5 mM and 1.0 mM) in a 1:5 effector/target (E/T ratio could improve the lysis effect of CAR-T cells. (
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PMC10850553
The images of immunofluorescent staining of IA lesions for C5ar1 (green), TNF-α (red), IL-1β (red), COX-2 (red), and merged images with nuclear staining by DAPI (blue) are shown.
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PMC11095939
As the experiment progressed, the experimenter became blind to the group allocation, and the principal investigator only knew the allocation at each stage.
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PMC9429973
Summary/Conclusion: The programme was feasible and satisfactory due to the adherence shown by most of the patients.
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PMC11247842
Moreover, a bivariate association analysis of the QTL at DGAT1 showed pleiotropic effects on mastitis resistance and milk yield .
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PMC9910796
Altogether, the predicted topology in combination with the biochemical and immunocytochemical evidence, indicate that pEP84R localizes in the inner envelope that encloses the viral core.
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PMC11772449
After the cells were fixed, the formation of autophagosomes showing green fluorescence was observed under a fluorescence microscope.
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PMC11655536
We demonstrated that HA induced MM cell death.
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PMC11257203
MN, Micronucleus; PCE, polychromatic erythrocyte; Indo, indomethacin; Cur, curcumin.
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PMC11513011
Cell proliferation was significantly suppressed in all cell lines, and apoptotic cells increased in the KK-47 and T24 cell lines after DIB.
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PMC11754432
Cell lines were purchased in April 2022 and routine mycoplasma testing was performed using Vendor®GeM clasic (Minerva Biolabs, Berlin, Germany).
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PMC11441402
Values greater than 100% indicated increased cell proliferation compared to the untreated control, values between 0% and 100% indicated inhibition of cell proliferation, and negative values indicated cell death.
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PMC11772449
The data of p38α (A, B), p38β (C, D), p38γ (E, F) and p38δ (G, H) in the Ualcan database website were analyzed.
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PMC11791478
Taken together, these data indicate that the use of zovodotin as the linker–payload in XB002 improved exposure and the toxicology profile compared with the use of a vedotin as the linker–payload.
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PMC8557138
Thus, this model allowed examining the responses of anti-angiogenic compounds as well as drug testing applications.
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PMC11715644
By the differential levels of actomyosin contractility, leader-follower hierarchy within the migrating epithelial cluster is established and forward movement is ensured.
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PMC9895440
Mechanistically, our ex vivo results show that SNX9 KO Tex have a lower expression of NR4A1, NR4A3, and TOX, which have been implicated in T cell exhaustion.
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PMC9429973
Ten pts discontinued due to AEs (n=3), proceeding to transplant (n=3), consent withdrawal (n=2), or disease progression (n=2).
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PMC11802929
We categorized peptides as weak-binders (column BindLevel = 0), medium-binders (column BindLevel = WB), or strong-binders (column BindLevel = SB) based on NetMHCpan prediction.
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PMC11768281
Several trials also utilized controlled human malaria infection (CHMI) and infection, treatment, and vaccination (ITV) with drug prophylaxis to understand the role of T-cells as a part of adaptive immunity against malaria.
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PMC8540692
However, NaBu mildly demethylated the promoter region of RASSF1A in A-172 and U-138 MG cells and, in the latter cell line, the combination treatment of CCM and NaBu was also effective.
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PMC11695623
The results show that it mainly involves biological processes such as DNA methylation, DNA replication, CD22 mediated BCR regulation, PD 1 signaling and so on.
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PMC10490530
Also, decreased expression of BCL2 when cells were treated with doxorubicin or TNFα and doxorubicin combination indicated a negative impact of p53 stabilization on NF-κB transcriptional activity (Supplementary Figure S8).
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PMC5386478
Cell cultures under hypoxic conditions were performed in 1% O2 gas mixture using a modulator incubator chamber.
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PMC10547921
The pharmacophore consists of two hydrophobic regions I and II and two hydrogen bonding regions that interact with Asp179β and Asn329α, laying the foundation for the rational design of ADC payloads with high specificity, strong affinity, and high efficiency.
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PMC11754436
Subsequently, Transfection at room temperature for 72 h, the cells were continuously cultured for 1 week using complete medium containing puromycin (ST551; 10 µg/ml; Beyotime Institute of Biotechnology) to construct cell lines with stable DHRS4-AS1 knockdown or overexpression.
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PMC11279397
For instance, Eugenol combined with acyclovir synergistically inhibited herpes virus replication in vitro , while the combination of germacone and oseltamivir demonstrated an additive effect in suppressing influenza virus infection both in vitro and in vivo ; these findings provided new insights for developing more effective strategies for antiviral therapy and drug combinations.
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PMC11521786
For example, HER2–HER3 signaling is highlighted as a relevant oncogenic driver in breast carcinomas that overexpress HER2.
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PMC10243817
GO analysis for differentially expressed genes was implemented by KOBAS software (version: 2.1.1) with a P < 0.05 to judge statistically significant enrichment.
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PMC11332076
After transfection, myc-tagged F-iIR, F-iIGF1R, iIR, and iIGF1R were detected in Cos-7 cells (upper panel in Fig. 1B).
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PMC11732628
Notably, the 143B cells had the lowest miR-490-3p expression; thus, we chose 143B cells for the subsequent studies.
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PMC11555465
Recent studies have explored the potential anticancer properties of T. gondii, demonstrating its ability to invade and destroy various human cancer cell lines, such as breast cancer cells (21), colon cancer cells (22) and lung cancer cells (23).
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PMC10877303
The structures were drawn using MarvinSketch software.
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PMC8414691
The sense and antisense gene-specific DOM-A primers were as follows: for-TCTGGTGCTCAGATCGTGTC; rev-GTTGTCTGCAGCACCTTCAA.
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PMC11695623
The cell precipitation was re-suspended in 100 μl binding buffer (TONBO, USA), 5 μl of AnnexinV-FITC and 5 μl of AAD-7 were added, and 400 μl of binding buffer was added after 15 min of incubation at room temperature.
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PMC11760643
All statistical analyses were conducted, and graphs were assembled, using GraphPad Prism software v8.0.2.
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PMC10890055
Differences in the media’s composition probably improved the cell fitness and decreased the cytotoxic effect of extracts in DMEM/Ham’s F-12 (rich medium) compared to the MEM medium (minimal medium), similarly to our previous study with ZnCl2 solutions in MEM and DMEM .
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PMC11400680
Once getting the precision and recall values, a precision-recall curve can be generated by plotting the precision against recall for different confidence threshold values.
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PMC9429973
Lenalidomide also induces immune modulation independent of del(5q) and has multiple effects on T-cell signaling; however, the molecular and cellular determinants that mediate this immunomodulatory function remain elusive.
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PMC9822769
Indeed, Kastner et al. aged seven diacetato Pt(IV) complexes at 37°C for 24 h in phosphate buffer at different pH values.
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PMC9596868
Synergistic effect of quercetin and MST-312 in A2780cisR and HCT116 cells. (
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PMC11024707
Furthermore, these mi-RNAs were not studied in terms of subthreshold autistic characteristics in non-autistic individuals.
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PMC11737091
Upon DBF4 knockdown, the tumor volume and weight were dramatically decreased in a xenograft model (Fig. 9A-C, n = 6), indicating that the tumor growth capability of ccRCC cells was reduced.
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PMC9878562
VAL-ACKR3-ΔC poorly scavenged CXCL11_12 AF647 indicating that the C-terminus of ACKR3 is required for scavenging and receptor internalization ( Figures S1B, C ), consistent with previous findings (6, 43).
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PMC11759543
Cytotoxicity of vorinostat for 24 h treatment.
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PMC9429973
However this report should be understood as a first effort for a much-needed national registry that would be of great importance to homogenize the study and management of this disease in Mexico.
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PMC10812665
This occurred at toxicant concentrations that did not deplete ATP.
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PMC7342409
There was no significant difference in the tumor volume between the drug-resistant group and the normal group.
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PMC7185206
Cells in this figure were numbered where helpful.
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PMC5386478
Importantly, TGM2-v1 silencing caused a marked and significant reduction of MPM cell viability in hypoxic conditions when compared with normoxia.
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PMC11790599
Given that macropinocytosis is a hallmark of cancer cells carrying oncogenes, further investigation into these intricate signaling pathways has the potential to unearth additional chemical and physiological stimuli responsible for initiating this unconventional mode of cell death, thereby enhancing our understanding and potentially opening new avenues for cancer treatment and therapeutic intervention.
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PMC11763126
H RIP assay revealing the interaction between YTHDF2 and TRPM3 mRNA.
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PMC11679326
We classified marine-derived lectins and lectin-like molecules according to their ability to cover aberrant glycosylation patterns in brain tumors to encourage exploration of the potential of these molecules for precision diagnostics and personalized therapy.
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PMC7723249
To further support our observation, studies using CCHFV clinical isolates instead of the CCHFV laboratory strain Ibar10200 used in this study has to be conducted.
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PMC11531735
We assessed the preventive potential of orally administered ER121 in countering MMTV-erbB2-driven tumors in a transgenic mouse model that develops HER2 tumors (see Figure 4).
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