OTAR3088/ChEMBL_dict_annotated · Datasets at Hugging Face

data dict	annotations listlengths 1 1
{ "text": "Materials and methods Statistical analysis All experiments were performed at least three times. A one-way ANOVA followed by a Tukey's post-hoc test was used to compare the RT-qPCR signals from the treated cells and the ELISA results. For comparison of RT-qPCR signals from treated cells to the hypothetical ...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 3473, "end": 3479, "text": "cannot", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Introduction The introduction of antiretroviral therapy (ART) has successfully limited the spread of Human Immunodeficiency Virus (HIV) and improved patient clinical outcomes. However, a complete cure for HIV infection remains out of reach, as the transcriptionally silent but replication-competent provirus...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 3416, "end": 3422, "text": "Jurkat", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Introduction The persistence of replication-competent, but transcriptionally inhibited HIV-1 proviral DNA in long-lived, latent cellular reservoirs is a significant barrier to the development of a functional cure [1,2] Even after long-term, suppressive antiretroviral therapy (ART), spontaneous reactivation...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 16663, "end": 16674, "text": "lymphocytes", "labels": [ "Cell" ] } }, { "from_name": "lab...
{ "text": "2. results 3. discussion Müller glial cells play fundamental roles in retinal tissue functions. Therefore, studies into their biology and functions may contribute to understanding the causes of retinal pathologies and to develop strategies to alleviate their outcomes. The aim of this study was to investiga...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 2564, "end": 2571, "text": "neurons", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Introduction Antiretroviral therapy (ART) has been highly effective at suppressing human immunodeficiency virus (HIV) replication, thus significantly reducing disease progression and mortality in infected individuals. However, ART is not curative and does not meaningfully impact persistent viral reservoirs...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 10297, "end": 10308, "text": "splenocytes", "labels": [ "Cell" ] } }, { "from_name": "lab...
{ "text": "2. results 3. discussion Cell surface receptors and their coupled intracellular signaling pathways have been intensively studied in many physiological and pathological processes over five decades. Due to the critical feature of these receptor-mediated signaling in promoting malignant proliferation, invasio...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 1092, "end": 1099, "text": "neurons", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Results Dcas9-targeted hiv-1 ltr-interactome analysis identified prmt3 as a ltr-binding factor Seeking host factors that specifically associate with the HIV-1 LTR, we conducted an LTR-interacted proteome analysis based on a refined version of a previously described nuclease-deficient Cas9 (dCas9)-targeted ...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 16487, "end": 16490, "text": "Raw", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Materials and methods Statistical analysis The data were described as mean ± standard deviation (SD) and the statistical significance was determined by one-way ANOVA before LSD test for multiple comparisons and independent-sample t-test for comparison between the two groups. The level of p *Results* Di...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 1396, "end": 1405, "text": "NCI-H1299", "labels": [ "Cell" ] } }, { "from_name": "label",...
{ "text": "Methods The cytotoxic effects of the A. incana DCM fraction were evaluated in a dose-dependent manner using the MTT assay on several cancer cell lines, with particular emphasis on HeLa cells. Flow cytometry was used to assess cell cycle arrest and apoptosis, while RT-qPCR quantified changes in the expressi...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 180, "end": 184, "text": "HeLa", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "2. results 3. discussion Conifer bark, the medicinal use of which dates back more than 2000 years, contains bioactive alkaloids, flavonoids, lignans, phenolic acids, proanthocyanidins, stilbenes, and terpenoids that contribute to its therapeutic potential. Various conifer bark extracts are used nowadays in...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 596, "end": 599, "text": "Don", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Introduction Hepatocellular carcinoma (HCC) is an exceedingly fatal malignancies, with mortalities that approximate the incidence rates worldwide [1]. HCC is usually diagnosed at advanced stages owing to late symptom manifestations with limited therapeutic options, leading to ineffective intervention and p...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 1723, "end": 1730, "text": "MCF-10A", "labels": [ "Cell" ] } }, { "from_name": "label", ...
{ "text": "Results IFN-γ significantly induced STAT1 phosphorylation, leading to a time-dependent upregulation of PD-L1 expression. Immunofluorescence confirmed that p-STAT1 is translocated to nucleus. Curcumin treatment inhibited STAT1 phosphorylation by 68% (p p *Conclusion* Curcumin effectively inhibits IFN-γ-...	[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 502, "end": 507, "text": "NSCLC", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Materials and methods Statistical analysis All experiments were performed at least three times. A one-way ANOVA followed by a Tukey's post-hoc test was used to compare the RT-qPCR signals from the treated cells and the ELISA results. For comparison of RT-qPCR signals from treated cells to the hypothetical ...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 3473, "end": 3479, "text": "cannot", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Introduction The introduction of antiretroviral therapy (ART) has successfully limited the spread of Human Immunodeficiency Virus (HIV) and improved patient clinical outcomes. However, a complete cure for HIV infection remains out of reach, as the transcriptionally silent but replication-competent provirus...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 3416, "end": 3422, "text": "Jurkat", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Introduction The persistence of replication-competent, but transcriptionally inhibited HIV-1 proviral DNA in long-lived, latent cellular reservoirs is a significant barrier to the development of a functional cure [1,2] Even after long-term, suppressive antiretroviral therapy (ART), spontaneous reactivation...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 16663, "end": 16674, "text": "lymphocytes", "labels": [ "Cell" ] } }, { "from_name": "lab...

{ "text": "2. results 3. discussion Müller glial cells play fundamental roles in retinal tissue functions. Therefore, studies into their biology and functions may contribute to understanding the causes of retinal pathologies and to develop strategies to alleviate their outcomes. The aim of this study was to investiga...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 2564, "end": 2571, "text": "neurons", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Introduction Antiretroviral therapy (ART) has been highly effective at suppressing human immunodeficiency virus (HIV) replication, thus significantly reducing disease progression and mortality in infected individuals. However, ART is not curative and does not meaningfully impact persistent viral reservoirs...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 10297, "end": 10308, "text": "splenocytes", "labels": [ "Cell" ] } }, { "from_name": "lab...

{ "text": "2. results 3. discussion Cell surface receptors and their coupled intracellular signaling pathways have been intensively studied in many physiological and pathological processes over five decades. Due to the critical feature of these receptor-mediated signaling in promoting malignant proliferation, invasio...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 1092, "end": 1099, "text": "neurons", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Results Dcas9-targeted hiv-1 ltr-interactome analysis identified prmt3 as a ltr-binding factor Seeking host factors that specifically associate with the HIV-1 LTR, we conducted an LTR-interacted proteome analysis based on a refined version of a previously described nuclease-deficient Cas9 (dCas9)-targeted ...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 16487, "end": 16490, "text": "Raw", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Materials and methods Statistical analysis The data were described as mean ± standard deviation (SD) and the statistical significance was determined by one-way ANOVA before LSD test for multiple comparisons and independent-sample t-test for comparison between the two groups. The level of p ***Results*** Di...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 1396, "end": 1405, "text": "NCI-H1299", "labels": [ "Cell" ] } }, { "from_name": "label",...

{ "text": "Methods The cytotoxic effects of the A. incana DCM fraction were evaluated in a dose-dependent manner using the MTT assay on several cancer cell lines, with particular emphasis on HeLa cells. Flow cytometry was used to assess cell cycle arrest and apoptosis, while RT-qPCR quantified changes in the expressi...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 180, "end": 184, "text": "HeLa", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "2. results 3. discussion Conifer bark, the medicinal use of which dates back more than 2000 years, contains bioactive alkaloids, flavonoids, lignans, phenolic acids, proanthocyanidins, stilbenes, and terpenoids that contribute to its therapeutic potential. Various conifer bark extracts are used nowadays in...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 596, "end": 599, "text": "Don", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Introduction Hepatocellular carcinoma (HCC) is an exceedingly fatal malignancies, with mortalities that approximate the incidence rates worldwide [1]. HCC is usually diagnosed at advanced stages owing to late symptom manifestations with limited therapeutic options, leading to ineffective intervention and p...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 1723, "end": 1730, "text": "MCF-10A", "labels": [ "Cell" ] } }, { "from_name": "label", ...

{ "text": "Results IFN-γ significantly induced STAT1 phosphorylation, leading to a time-dependent upregulation of PD-L1 expression. Immunofluorescence confirmed that p-STAT1 is translocated to nucleus. Curcumin treatment inhibited STAT1 phosphorylation by 68% (p p ***Conclusion*** Curcumin effectively inhibits IFN-γ-...

[ { "result": [ { "from_name": "label", "to_name": "text", "type": "labels", "value": { "start": 502, "end": 507, "text": "NSCLC", "labels": [ "Cell" ] } }, { "from_name": "label", ...