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Necrobiosis lipoidica (nl) is a rare chronic granulomatous dermatitis first described in 1929 by oppenheim that usually appears in the lower extremities that affects about 0.31.2% of diabetic patients, the majority of whom have type 1 diabetes . We report a case of a 16 y old girl who developed lesions on the lower ext... |
Primary immunoglobulin light chain amyloidosis (al amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system . Cases of atypical al amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the management and cli... |
Conduit artery flow - mediated dilation (fmd) is a widely used noninvasive method to assess endothelial function . Diminished fmd is widely assumed to reflect impaired dilator function of nitric oxide (no), based on several studies reporting the absence or substantial attenuation of fmd following infusion of the no syn... |
Bacterial activity has proved to be the main causative factor for placement and replacement of restorations . It was confirmed histologically that fermentative organisms remained viable under non - antispetic restorations for as long as 139 days and that only a portion of the tooth is sterile after termination of routi... |
Flurodeoxyglucose (f - fdg) positron emission tomography / computed tomography (pet / ct) has become the imaging modality of choice for initial staging, follow - up and treatment response assessment in patients with hodgkin's lymphoma and has proved superior to contrast enhanced ct (cect) in these settings . F - fdg pe... |
Superficial leiomyosarcomas are rare malignant tumors that account for only 510% of all soft tissue sarcomas . They can be subdivided into two types according to its primary site of origin: deep subcutaneous and superficial cutaneous types . Primary cutaneous leiomyosarcoma (pcl) is a rare subtype with few isolated cas... |
In some beyond li - ion battery concepts, li metal is used as the anode, e.g., in li / air, li / sulfur, and some redox flow batteries . Li metal benefits from a high theoretical specific capacity (3860 ma h g), low density (0.59 g cm), and the lowest negative electrochemical potential (3.04 v vs the standard hydrogen ... |
With the introduction of ovulation - inducing agents in the late 1960s and assisted - reproductive techniques in the 1970s, the frequency of multiple pregnancies and multiple birth have been increasing (1 - 5). In korea, the frequency of twins has recently been increased by three times for the past 20 yr (6). To date, ... |
The sign of leser - trelat historically has been characterized as the sudden eruption of numerous seborrheic keratoses and considered an ominous sign of internal malignancy, as it is classically described before the diagnosis of malignancy . The seborrheic keratoses themselves are benign and, in some cases, have been r... |
Thirty bilingual (english - malayalam) individuals (16 males and 14 females) diagnosed with alzheimer's disease in the age range of 65 - 88 years (mean 77.4, sd 6.6) participated in the study . Participants were diagnosed by a medical team including a neurologist, a neuropsychiatrist and experts in geriatrics . On the ... |
Gastrointestinal stromal tumors (gists) are the most common type of mesenchymal tumors in the gastrointestinal tract . Their biological behavior correlates with clinicopathological parameters such as mitotic rate, tumor size and tumor location, as well as with the molecular alterations of kit and pdgfr . Imatinib is a ... |
Anterior cervical discectomy and fusion (acdf) is commonly performed to treat one- and two - level cervical spondylosis . Favorable fusion rates have been reported; nonunion rate i4% for single level plated acdf with allograft.1,2 however, fusion success declines with the number of treated levels.3 reported pseudarthro... |
Nowadays, one - dimensional (1-d) nanomaterials (nanorods, nanowires, nanobelts and nanotubes) have been attractive due to their physical and chemical properties . These nanostructures, that have great potential applications in the next generation of nanodevices . Various methods such as chemical vapor deposition (cvd)... |
The idiopathic retinitis, vasculitis, aneurysms and neuroretinitis (irvan) syndrome is a retinal vascular disorder of unknown etiology characterized by three major criteria (multiple leaking aneurysmal dilations, retinal vasculitis and neuroretinitis) and three minor criteria (peripheral capillary nonperfusion, retinal... |
Sinonasal teratocarcinosarcoma (sntcs) is a very unusual and aggressive neoplasm first characterized as a separate entity by heffner and hyams in 1984.1 it is currently defined by the world health organization as a complex malignant sinonasal neoplasm combining features of teratoma and carcinosarcoma that typically inc... |
An estimated 18.8 million adults in the united states are reported to have diabetes mellitus . . Studies with intensive glycemic control reveal significant reductions in microvascular complications and possible long - term reductions in macrovascular disease . Several professional organizations (american diabetes assoc... |
Epilepsy affects 12% of the population worldwide and can be considered one of the most prevalent neurological illnesses . Furthermore, between 20 and 25% of epileptic patients are resistant to drug treatment . The most common type of drug - resistant epilepsy is temporal lobe epilepsy (tle); however, patients with this... |
Hcv infection is a major concern for human health with an estimated 3% of the world's population infected . Hcv primarily infects hepatocytes in the liver culminating in serious and progressive liver disease including chronic hepatitis, cirrhosis, and hepatocellular carcinoma . However, only a fraction of patients resp... |
The increase in atmospheric co2 concentrations has led to a continuous increase in the partial pressure of co2 and decrease in ph in the oceans since pre - industrial times, a process called ocean acidification (oa). Since then, the ocean water ph has declined from approximately 8.2 to 8.1, and will reach ph 7.8 by the... |
Probiotics are defined as live microorganisms which when administered in adequate amounts confer a health benefit to the host . In acute infections, probiotics may boost the protection afforded by commensal microbiota through competitive interactions and direct antagonism of pathogens due in part to the production of a... |
Congenital adrenal hyperplasia (cah) is the commonest cause of adrenal insufficiency (ai) in childhood and 21-hydroxylase deficiency is the most frequently occurring form, accounting for approximately 95% of cases and having an incidence of between 1 in 9,000 and 1 in 20,000 births [13]. 21-hydroxylase deficiency is au... |
Situs inversus totalis (sit) is a rare congenital anomaly with an incidence of 1 in 10,00050,000 persons . Sit refers to complete right - left transformation or a mirror image of the normal arrangement of body organs . The anatomic arrangement in a patient with sit is complete transposition of all viscera in the thorac... |
Laceration of the lumbar artery during renal biopsy has been reported only in four instances . A 58-year - old lady presented with swelling of face that progressed to involve abdomen and feet, along with oliguria, cola colored urine and breathlessness on minimal exertion . On examination, she had puffiness of eyelids a... |
A genome - wide approach opens up the possibility of obtaining new information in the field of genome instability . Nevertheless, every method has its own restrictions . In our comments, we compare cytological, genetic and genome - wide molecular analyses of mobile element transposition rates in hybrid genomes . The mo... |
The success of endodontic treatment is based on the effective decontamination of the root canal system, whereas microbial agents are essential for the development and maintenance of pathological processes that damage the pulp and periapical region . Despite technological and scientific advances in endodontics, the pers... |
Severe congenital neutropenia (scn) is a disorder of neutrophil production predisposed to recurrent and severe bacterial infection from early infancy . Although many genetic aberrations responsible for this condition were reported, scn largely derives from elane gene mutations which are known to be correlated with more... |
Improving the effectiveness and efficiency of the informed consent process is a critical health policy issue . Informed consent is an essential element of ethical biomedical research, with federal regulatory requirements that are intended to ensure autonomy of the research participant s decision to engage in research a... |
Denture lining materials are widely used for the base of a denture to reduce pain or to improve the fit between the denture and mucous membrane.1 they act as a cushion and provide an even distribution of functional load onto the stress - bearing mucosa.2 application of a soft lining material to the dentures can also in... |
Respiration is the exchange of blood and oxygen via the lungs, which are the essential part of the ventilation system1 . The major inspiratory muscles that engage during inspiration are the diaphragm and external intercostal muscles . Meanwhile, the accessory inspiratory muscles that engage spine movement are the stern... |
Perceptual learning involves relatively long - lasting changes to organism's perceptual systems that improve its ability to respond to its environment . In an experimental setting, this generally translates to an improvement in performance on a perceptual task with training . One of the defining characteristics of perc... |
Micrornas (mirnas) are genome - encoded single - stranded rna molecules of ~22 nt in length, which play a significant role in regulation of gene expression in eukaryotes . Many details on biogenesis and interactions of mirnas are known (see recent reviews, e.g., [1, 2]). Briefly, mirnas can be encoded by mirna genes, b... |
In a 2009 review paper, puhl and heuer documented the incredible scope of discrimination faced by overweight individuals, including in health care settings, the workplace, and media . In addition, they discuss the relatively sparse data on interventions aiming to eradicate these conditions (puhl and heuer, 2009). Indee... |
A diagnostic colonoscopy can be performed safely without prior consultation with a gastroenterologist, which increases efficiency and reduces delays and costs 2 3 4 . This practice of open access endoscopy (oae) has gained popularity, particularly in the western world . Despite these benefits, concerns exist about impr... |
The ghna nutrition survey was administered online and included 3030 participants from the united states (n = 1022), germany (n = 1002), and the united kingdom (united kingdom; n = 1006) using a convenience - based sample with recruitment completed by instantly (formerly usamp), a marketing and research firm . The sampl... |
Microglia - mediated neuroinflammation and t cell infiltration constitute major hallmarks for neurodegeneration, yet the molecular and cellular crosstalk between microglia and t cells is poorly understood . Lipopolysaccharide (lps) from rhodobacter sphaeroides (lps - rs) is a potent tlr4 antagonist in both human and mu... |
In today's cost - conscious health care environment, equity and efficiency are becoming increasingly important considerations in managing and evaluating health care systems, especially as pressure to contain further growth in health care expenditures increases . Equity and efficiency are an integral and essential part ... |
The marketing, distribution, prescription and use of drugs in a society, with special emphasis on resulting medical, social and economic consequences is known as drug utilization research . It is an important tool to study the clinical use of drugs in populations and its impact on health - care system . The critical ca... |
Leishmania parasites are obligatory intracellular protozoa living in macrophages of humans and many other vertebrates . L. major is one of the main causes of the cutaneous form of the leishmaniasis in the world (1). Most of leishmania studies have yet been focused on leishmania itself or the immunogenicity and pathogen... |
Osteoporosis is defined by the who as a bone mineral density (bmd) of 2.5 standard deviations or more below the young normal mean . On this basis 26 million people in america are osteoporotic.1, 2 most of the fractures in the osteoporotic individuals occur in the proximal humerus, distal forearm, vertebrae, pelvis, hip... |
Ocular siderosis (os) is a severe sequel of retained iron - containing intraocular foreign body (iofb). A ferrous iofb undergoes dissociation resulting in the deposition of iron in the intraocular epithelial structures, notably the lens epithelium, iris and ciliary body epithelium, and the sensory retina, where it exer... |
Positive peritoneal washings are considered to be an important factor in management of patients with gynecological malignancies . Patients with positive peritoneal washings have been found to have worse prognosis than patients without malignant cells in cytology . Positive peritoneal washing in endometrial cancer is as... |
Vitamin d is a hormone with multiple physiological actions, many effects of which have been found to occur outside its classical role in calcium homeostasis . We now know that vitamin d receptors (vdrs) are expressed in many cell types, including various immune cells, suggesting the role of vitamin d on immune system .... |
Il-18 is a pleiotropic proinflammatory cytokine that stimulates production of ifn-, tnf-, il-1, il-2, adhesion molecules and apoptosis factors, increasing t - lymphocyte proliferation, and enhancing the lytic activity of nk - cells . It participates in the cellular and humoral immune response, both innate and adaptive ... |
Recurrent pregnancy loss (rpl) or habitual miscarriage is the loss of three or more consecutive pregnancies before the 20 week of gestation (1). The world health organization (who) has defined a miscarriage as the loss of a fetus or embryo weighing 500 g, which would normally be at 2022 weeks of gestation . It varies w... |
Pigment - epithelium - derived factor (pedf) is a glycoprotein that belongs to the superfamily of serpin protease inhibitor proteins without inhibitory function, encoded by the gene serpinf1 located on chromosome 17p13 which is well conserved in evolution . It is a protein of 418 amino acids, with a size of 50 kda and ... |
Topical steroid - dependent face is a common condition resulting from misuse of topical steroids over the face which may lead to erythema, burning and scaling . . The common indications are conditions such as psoriasis, lichen planus, eczema, lichen simplex chronicus, and other steroid - responsive dermatoses . However... |
In developed countries, the population of elderly people is steadily increasing, which is associated with increased needs for permanent institutional care . In 2009 in poland, 13.3% of people were aged 65 years or older, and the annual growth for this age group is about 57,000 people . Approximately 17,500 persons in t... |
Acute appendicitis and typhlitis are the most common causes of gastrointestinal surgical complications in children undergoing chemotherapy for acute leukemia with reported incidences of 0.54.4% and 1.76.7% respectively [14]. Early diagnosis by radiologic imaging is essential as appendicitis usually requires emergent su... |
The perioperative period of major oncological surgery is marked by several potential causes for renal injury such as hypotension, volume depletion, self - regulation disorders of the kidney, surgical trauma and drug - induced nephrotoxicity . On the other hand, patients with oncological malignancies are susceptible to ... |
Natural killer t (nkt) cells are recently discovered innate - like subset of lymphocytes expressing both nk and t cell markers . Nkt cells are a phenotypically and functionally diverse subset of t cells that recognize self- and microbial lipids [1, 2]. Most nkt cells are restricted by mhc - i like molecule cd1, which c... |
Due to the limited capacity of our visual system, selective attention needs to efficiently filter relevant stimuli from the incoming stream of visual information . Which stimuli are selected for further processing is a complex process that depends on various factors such as physical salience (e.g., [1, 2]), task - rele... |
Though aortic dissection is very rare in young children,1) this abnormality is certainly recognized, particularly in those with congenital heart disease, connective tissue disorders, or severe trauma.2) early diagnosis and treatment is crucial for this life - threatening abnormality.3) aortic dissection type b is defin... |
Among technical errors which might cause misinterpretation of the us image of the examined focal lesion one can number inter alia artifacts resulting from the volumetric averaging in near and far field . An artifact in the near field can result in lesions localized at depths up to 10 mm not being visualized and small h... |
Matrix tablets offer a great potential as oral drug delivery system due to their simplicity, cost effectiveness, reduced risk of systemic toxicity, and minimal chance of dose dumping [1, 2]. They exclude complex production procedures such as coating and pelleatization during manufacturing, and drug release rate from th... |
Emotional health is a state of emotional and psychological wellbeing in which the individual perceives his surroundings realistically, copes with routine stressors of life, is capable of interacting with others, realizes his potentials, and functions fruitfully (1). According to world health organization statistics, in... |
Sarcomatoid variant of urothelial carcinoma (suvc) is rare and because of its rarity most practitioners including urologists and oncologists may not have encountered the disease . The literature on sarcomatoid variant of urothelial carcinoma has been reviewed in the ensuing paper . Sarcomatoid variant of urothelial car... |
He presented with a 10-year history of voiding difficulty . Before this presentation, a digital rectal examination revealed bilateral enlargement of the prostatic lobes . Under a clinical diagnosis of bph, he was administered tamsulosin 0.2 mg once with the insertion of a urethral foley catheter . Transrectal ultrasono... |
Hypothalamic - pituitary - adrenal (hpa) axis dysfunction in mood disorders is one of the most robust findings in biological psychiatry . However, considerable debate surrounds the nature of the core abnormality, its cause, consequences and treatment implications . To review the evidence for the role of hpa axis dysfun... |
In sub - saharan africa, hiv prevalence trends differ between individuals with different socioeconomic backgrounds . Hiv infections were concentrated among those with higher levels of education or wealth in sub - saharan africa before 1996 in many countries . It therefore seems that during the 1980s and 1990s, in the a... |
Cardiovascular disease (cvd), including heart attack, angina, and stroke, is ranked as the number one cause of mortality worldwide . Statins, cholesterol - lowering drugs, are first choice drugs for reducing the chance of suffering a cvd event . Although not thought of traditionally as antimicrobials, statins have been... |
Systemic lupus erythematosus (sle) is an autoimmune disease characterized by immune system dysfunction and the production of autoantibodies that lead to inflammation and tissue damage . T - lymphocytes (t - cells) promote inflammation through producing co - stimulatory signals and cytokines that activate dendritic cell... |
Oculogyric crisis (ogc), classified as eyeball dystonia, was first described in patients suffering from encephalitis lethargica.1 nowadays, this symptom is more frequently observed as a side effect of treatment with dopamine receptor - blocking drugs (drbds).2 it manifests as spasmodic deviations of the eyeballs, mainl... |
It arises from the superior margin of the sphenopalatine foramen and accounts for 0.05% of all head and neck neoplasms . The typical histopathologic appearance of jna is numerous wide, irregular vessels with a single layer of endothelial cells embedded in fibrous stroma . The abundant vascular component is responsible ... |
A secondary neoplasm of the thyroid gland is a distinctly uncommon cause of thyroid enlargement, the reported prevalence of which range from 2% to 3% of all thyroid malignancies, autopsy series, however, report a prevalence varying from 1.25% to 24% these tumors mimic primary thyroid gland tumors and often lead to diag... |
Hepatocellular carcinoma (hcc) is the sixth most common cancer worldwide, and it is the third most common cause of death from cancer . Recent studies demonstrated clinical features of multiple primary malignancies involving hcc [2, 3]. However, hcc patients bearing other malignancies with distal metastasis are not only... |
In humans, cryoglobulinemia can be responsible for a membranoproliferative glomerulonephritis (mpgn), which is characterized by the formation and/or deposition of immunoglobulins (igs) and complement in the glomeruli, followed by an influx of inflammatory cells [1, 2, 3]. Since the early studies to investigate compleme... |
Despite the availability of a large number of therapeutic agents for the management of type 2 diabetes (t2d), patients continue to present with high levels of glycated hemoglobin a1c (hba1c) in actual clinical practice . Insulin is the most potent therapy for t2d; however, physicians often take a conservative approach ... |
The sequencing of several genomes and the hapmap project, coupled to high - density genotyping technologies and new statistical tools, have made possible the systematic interrogation of the genetic basis of complex traits in humans . Largely consistent with the community's expectations, the past two years have seen a l... |
Evidence is accumulating that enteric glial cells (egc) are the morphological and functional equivalent of the astrocytes found in the central nervous system (cns).recent studies have demonstrated that egc participate in homeostasis of the gastrointestinal tract . In transgenic mouse models in which egc are selectively... |
Out of any other entities in the world of pharmaceuticals, perhaps penicillin needs no introduction . Right from the time of world war ii, penicillin, the first discovered -lactam antibiotic (la), has been and still is one of the most widely used antibiotic agents, in terms of annual bulk production (~3 10 kg / year), ... |
Biomarkers for the early diagnosis, management, and treatment of alzheimer's disease (ad) are important . In vivo cross - section imaging during an annual comprehensive eye exam with a dilated pupil has been available for a decade for glaucoma and macular degeneration, and this same imaging, using optical coherence tom... |
In our rush to embrace th17 cells as the purveyors of tissue damage, we should not forget that cytokines produced by th1 cells and other cell types are critical in promoting various forms of inflammation . Administration of ifn-, for example, worsened disease in patients with ms (13). And blocking tumor necrosis factor... |
But, considered little more than cellular garbage cans acting to discard unwanted molecular components, exosomes remained little studied for the next 10 years . Over the past few years, however, evidence has begun to accumulate that the vesicles are like signaling payloads containing cell - specific collections of prot... |
A substantial amount of research has focused on biomarkers that identify people at higher risk of developing cardiovascular disease.1 one indicator that seems to play a pivotal role is dysfunction of the autonomic nervous system . Specifically, increased sympathetic and/or decreased parasympathetic activity has been as... |
Epilepsy is the second most prevalent neurological disorder (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document}} {} \(\sim 1\) \end{document}%... |
It is currently recognized as a dynamic process since periods of demineralization alternate with periods of remineralization through the action of calcium, fluoride, and phosphorous present in the saliva . It is, therefore, viewed as a biofilm induced disease cause by an imbalance in physiologic equilibrium between too... |
The generation and preservation of the microenvironment of the tear film is guaranteed by the biological interplay between the ocular surface together with the related glands and local neural interconnections, that represent the core players for the protection of the transparency of the cornea and the health of the ocu... |
Even under normal operation of nuclear power plants (npps) discharges of radioactive substances into the atmosphere take place . Considerable attention is given to monitoring of radioactive noble gases, iodine, c, fission and activation products in particulate form in airborne effluents . The annual discharged activiti... |
Biological or biopharmaceuticals are drugs produced from living cells through the biological process, and mimic natural biological substances such as hormones . Biosimilars are copy drugs similar to biological drugs that has already been authorized (the biological reference medicine), hence similar but not identical . ... |
An incisional biopsy from mandibular region of a 45-year - old female patient was submitted to our department of oral pathology and microbiology with the history of pain and swelling in the right lower back teeth region for past 2 months . The clinical details given to us were, swelling in the right lower cheek region ... |
Genetically modified plant - pesticidal crops with constitutive expression of insecticidal protein (such as the cry proteins derived from the bacterium bacillus thuringiensis) require some form of resistance management program to delay the rapid evolution of resistance in targeted insects to expressed toxins . Because ... |
High - throughput genotyping technologies contribute greatly to the hunt for susceptibility genes for complex diseases by constantly improving the precision of and the capacity for parallel genotyping 1, 2, 3 . Driven by these emerging technologies, some challenging projects, such as hapmap phase iiii 4, 5, encode 6, 7... |
Early atherogenesis is characterized by the recruitment of circulating leukocytes (e.g., monocytes / macrophages and t - lymphocytes etc .) Into artery wall, the formation of foam cells in the vessel intima, leading to the development of atherosclerotic lesions . The inflammatory responses in the atherosclerotic lesion... |
Alopecia areata (aa) is a chronic, organ specific autoimmune disease, probably mediated by autoreactive t cells, which affects the hair follicles and sometimes the nails . There is a high frequency of a family history of aa in affected persons, ranging from 10% up to 42% of cases . Clinically, the disease manifests as ... |
Polycystic ovary syndrome (pcos), also known as stein - leventhal syndrome, is a common endocrine disorder that occurs in 510% of women of reproductive age . According to the 2003 rotterdam criteria, it is usually defined by presence of at least 2 out of the following 3 features: i) oligoovulation or anovulation, ii) c... |
Polycythemia vera (pv) is a myeloproliferative neoplasm (mpn) which is characterized by the proliferation of red blood cells independent of a normal control mechanism . The majority of patients have a mutation of the janus kinase 2 (jak2) gene . Diagnosis can be obtained by the examination of a complete blood count (cb... |
Ohtahara syndrome is a devastating infantile epileptic encephalopathy, which has an onset within the first few weeks of life, is associated with predominantly tonic seizures, and shows suppression - burst background on eeg . It is one of the epileptic encephalopathies that are characterized by frequent and medically in... |
The online version of this article (doi:10.1007/s00227 - 011 - 1643 - 5) contains supplementary material, which is available to authorized users . White sharks, carcharodon carcharias, observed off the coast of california belong to a genetically distinct population unique to the eastern pacific (jorgensen et al . 2010)... |
For many patients with multivessel disease, pci is a definitive alternative to coronary artery by - pass graft (cabg) [1, 2]. Complete revascularization remains a desirable goal, and a satisfactory outcome may be obtained with complete revascularization with ptca or cabg [4, 5]. However, complete revascularization may ... |
One - dimensional (1d) nanostructured magnesium salts with different morphologies, such as needle, rod, wire, tube, and belt, have attracted much attention because of their unique properties and potential applications in nanotechnical fields . Up to now much work has been focused on the control of the morphologies of 1... |
Voluntary euthanasia (ve) is the act of requesting deadly medical practices in order to terminate one s life (1). The process of decision making (like that for ve) is composed of two interwoven brain based components (2). One is the conscious power of analyzing the condition and utilizing algorithmic like strategies, w... |
Benign acute childhood myositis (bacm) is a self - limiting process characterized by sudden onset of muscle pain, more often calf pain, manifested by walking difficulty . Since many clinicians are not familiar with bacm, it is often misdiagnosed and interpreted as a more severe and complex disease . We report the case ... |
One of the measures of child health and the health status of the general populace is infant mortality or mortality, which is well studied in jamaica and the wider caribbean[111]. The simple rationale for the use of mortality in evaluating health status is owing to its ease in which it can be used to precisely measure i... |
Succinic acid is a member of the four - carbon dicarboxylic acid family in tricarboxylic acid cycle (tca) and has a wide range of applications in the fields of surfactants, green solvents, and pharmaceutical intermediates as an important four - carbon intermediate compound . Succinic acid is classified as the most prom... |
We selected nine cases of rlh, 78 cases of dlbcl, 13 cases of ptcl - nos, and 13 cases of nktcl based on the criteria that the paraffin blocks were well preserved with a sufficient amount of tissue for evaluation . Ihc reactions were performed on paraffin tissue sections using an automated ihc stainer (ventana benchmar... |
In men, testosterone concentrations decline gradually with age, unlike the dramatic fall in estrogen levels at the time of menopause in women . Testosterone deficiency is common in men with type 2 diabetes and it may contribute to not only impaired performance, mood, and libido, but also insulin resistance and metaboli... |
We reviewed data on mumps cases reported to the registration system for notifiable infectious diseases in the netherlands (osiris) during september 1, 2009august 31, 2012 . Notification criteria for mumps include> 1 related symptom (i.e., acute onset of painful swelling of the parotid or other salivary glands, orchitis... |
Posttranslational modifications on proteins offer spectacular diversity and functional variety to an organism's otherwise constrained proteome . Sumoylation is one such ptm whose vast expanse of biological implications in organisms has brought it under attention; still till now many of its functional outcomes are not k... |
Historically, among various cultures, weight gain has been viewed as a sign of wealth and prosperity but as the dynamics of food production and consumption have changed, the world now faces an epidemic of obesity . According to the world health organization (who), worldwide prevalence of obesity has doubled since 1980 ... |
Women of reproductive age (wra) in poor countries are at high risk for micronutrient deficiencies, particularly iron and zinc . Who estimates that 30.2% of nonpregnant and 41.8% of pregnant women suffer from anemia, much of it due to iron deficiency [13]. Some 1.2 billion people worldwide are at risk of inadequate zinc... |
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