import argparse import json from pathlib import Path from typing import Any, Dict, List, Optional import matplotlib.pyplot as plt DEFAULT_BUCKET_ORDER = ["low", "mid", "high"] def parse_args(): parser = argparse.ArgumentParser( description="Plot homework results for the DeepSTARR / GENERator assignments" ) parser.add_argument( "--task1_test_results", type=str, default="results/deepstarr_regression/test_results.json", help="Path to task 1 test_results.json", ) parser.add_argument( "--task2_generation_summary", type=str, default="results/deepstarr_sft_valid/generation_summary.json", help="Path to task 2 generation_summary.json", ) parser.add_argument( "--task3_generation_summary", type=str, default="results/deepstarr_sft_conditioned_valid/generation_summary.json", help="Path to task 3 generation_summary.json", ) parser.add_argument( "--task3_scoring_summary", type=str, default="results/deepstarr_conditioned_scoring/scoring_summary.json", help="Path to task 3 scoring_summary.json", ) parser.add_argument( "--output_dir", type=str, default="report/figures", help="Directory to save plots", ) return parser.parse_args() def load_json(path: str) -> Optional[Dict[str, Any]]: p = Path(path) if not p.exists(): print(f"[WARN] Missing file: {p}") return None with open(p, "r", encoding="utf-8") as f: return json.load(f) def configure_matplotlib(): plt.style.use("seaborn-v0_8-whitegrid") plt.rcParams["figure.dpi"] = 180 plt.rcParams["savefig.dpi"] = 220 plt.rcParams["font.size"] = 11 plt.rcParams["axes.titlesize"] = 13 plt.rcParams["axes.labelsize"] = 11 def plot_task1_regression_metrics(task1: Dict[str, Any], output_dir: Path) -> Optional[Path]: pearson_values = [ task1.get("test_pearson_label_0"), task1.get("test_pearson_label_1"), task1.get("test_pearson"), ] r2_values = [ task1.get("test_r2_label_0"), task1.get("test_r2_label_1"), task1.get("test_r2"), ] if any(value is None for value in pearson_values + r2_values): return None labels = ["Label 0", "Label 1", "Overall"] colors = ["#2C7FB8", "#41B6C4", "#253494"] fig, axes = plt.subplots(1, 2, figsize=(11.5, 4.6)) for ax, values, title, ylabel in [ (axes[0], pearson_values, "Task 1 Pearson Correlation", "Pearson"), (axes[1], r2_values, "Task 1 R2 Score", "R2"), ]: bars = ax.bar(labels, values, color=colors, width=0.62) ax.set_ylim(0.0, max(0.85, max(values) + 0.08)) ax.set_ylabel(ylabel) ax.set_title(title) for bar, value in zip(bars, values): ax.text( bar.get_x() + bar.get_width() / 2, bar.get_height() + 0.015, f"{value:.3f}", ha="center", va="bottom", ) fig.suptitle("Homework 1: Enhancer Activity Prediction", y=1.02, fontsize=14) fig.tight_layout() output_path = output_dir / "task1_regression_metrics.png" fig.savefig(output_path, bbox_inches="tight") plt.close(fig) return output_path def plot_generation_comparison( task2: Dict[str, Any], task3: Dict[str, Any], output_dir: Path ) -> Optional[Path]: metrics = [ ("mean_bp_accuracy", "BP Accuracy"), ("valid_dna_rate", "Valid DNA Rate"), ("unique_rate", "Unique Rate"), ] if any(task2.get(key) is None or task3.get(key) is None for key, _ in metrics): return None labels = [label for _, label in metrics] task2_values = [task2[key] for key, _ in metrics] task3_values = [task3[key] for key, _ in metrics] x = list(range(len(labels))) width = 0.34 fig, ax = plt.subplots(figsize=(8.8, 5.2)) bars1 = ax.bar( [i - width / 2 for i in x], task2_values, width=width, color="#3182BD", label="Task 2 Unconditional", ) bars2 = ax.bar( [i + width / 2 for i in x], task3_values, width=width, color="#E6550D", label="Task 3 Conditioned", ) ax.set_xticks(x) ax.set_xticklabels(labels) ax.set_ylim(0.0, 1.1) ax.set_ylabel("Value") ax.set_title("Task 2 vs Task 3: Generation Quality Comparison") ax.legend() for bars in [bars1, bars2]: for bar in bars: ax.text( bar.get_x() + bar.get_width() / 2, bar.get_height() + 0.02, f"{bar.get_height():.3f}", ha="center", va="bottom", fontsize=9, ) fig.tight_layout() output_path = output_dir / "task23_generation_comparison.png" fig.savefig(output_path, bbox_inches="tight") plt.close(fig) return output_path def _get_bucket_summary(task3_scoring: Dict[str, Any]) -> Optional[Dict[str, Dict[str, Any]]]: if "by_activity_bucket" in task3_scoring: return task3_scoring["by_activity_bucket"] if "by_condition_token" in task3_scoring: return task3_scoring["by_condition_token"] return None def _ordered_buckets(bucket_summary: Dict[str, Dict[str, Any]]) -> List[str]: present = list(bucket_summary.keys()) ordered = [bucket for bucket in DEFAULT_BUCKET_ORDER if bucket in present] remainder = [bucket for bucket in present if bucket not in ordered] return ordered + sorted(remainder) def plot_task3_bucket_prediction_sum( task3_scoring: Dict[str, Any], output_dir: Path ) -> Optional[Path]: bucket_summary = _get_bucket_summary(task3_scoring) if not bucket_summary: return None buckets = _ordered_buckets(bucket_summary) generated = [bucket_summary[b]["mean_generated_prediction_sum"] for b in buckets] reference = [bucket_summary[b]["mean_reference_prediction_sum"] for b in buckets] x = list(range(len(buckets))) width = 0.34 fig, ax = plt.subplots(figsize=(8.6, 5.2)) bars1 = ax.bar( [i - width / 2 for i in x], reference, width=width, color="#9ECAE1", label="Reference Sequence", ) bars2 = ax.bar( [i + width / 2 for i in x], generated, width=width, color="#08519C", label="Generated Sequence", ) ax.set_xticks(x) ax.set_xticklabels([bucket.capitalize() for bucket in buckets]) ax.set_ylabel("Predictor Score Sum") ax.set_title("Task 3: Predictor Score by Activity Bucket") ax.axhline(0.0, color="black", linewidth=0.8) ax.legend() for bars in [bars1, bars2]: for bar in bars: y = bar.get_height() offset = 0.03 if y >= 0 else -0.07 ax.text( bar.get_x() + bar.get_width() / 2, y + offset, f"{y:.3f}", ha="center", va="bottom" if y >= 0 else "top", fontsize=9, ) fig.tight_layout() output_path = output_dir / "task3_bucket_prediction_sum.png" fig.savefig(output_path, bbox_inches="tight") plt.close(fig) return output_path def plot_task3_bucket_deltas( task3_scoring: Dict[str, Any], output_dir: Path ) -> Optional[Path]: bucket_summary = _get_bucket_summary(task3_scoring) if not bucket_summary: return None buckets = _ordered_buckets(bucket_summary) delta_l0 = [bucket_summary[b].get("mean_prediction_delta_label_0", 0.0) for b in buckets] delta_l1 = [bucket_summary[b].get("mean_prediction_delta_label_1", 0.0) for b in buckets] delta_sum = [bucket_summary[b].get("mean_prediction_delta_sum", 0.0) for b in buckets] positive_rate = [bucket_summary[b].get("positive_delta_rate", 0.0) for b in buckets] x = list(range(len(buckets))) width = 0.25 fig, axes = plt.subplots(1, 2, figsize=(11.2, 4.8)) bars_l0 = axes[0].bar( [i - width / 2 for i in x], delta_l0, width=width, color="#31A354", label="Delta Label 0", ) bars_l1 = axes[0].bar( [i + width / 2 for i in x], delta_l1, width=width, color="#756BB1", label="Delta Label 1", ) axes[0].axhline(0.0, color="black", linewidth=0.8) axes[0].set_xticks(x) axes[0].set_xticklabels([bucket.capitalize() for bucket in buckets]) axes[0].set_ylabel("Prediction Delta") axes[0].set_title("Task 3: Label-wise Delta by Bucket") axes[0].legend() for bars in [bars_l0, bars_l1]: for bar in bars: y = bar.get_height() offset = 0.03 if y >= 0 else -0.06 axes[0].text( bar.get_x() + bar.get_width() / 2, y + offset, f"{y:.3f}", ha="center", va="bottom" if y >= 0 else "top", fontsize=8, ) bars_sum = axes[1].bar( [i - width / 2 for i in x], delta_sum, width=width, color="#E6550D", label="Delta Sum", ) bars_rate = axes[1].bar( [i + width / 2 for i in x], positive_rate, width=width, color="#FDD0A2", label="Positive Delta Rate", ) axes[1].axhline(0.0, color="black", linewidth=0.8) axes[1].set_xticks(x) axes[1].set_xticklabels([bucket.capitalize() for bucket in buckets]) axes[1].set_ylabel("Value") axes[1].set_ylim(min(-0.25, min(delta_sum) - 0.08), max(1.0, max(positive_rate) + 0.1)) axes[1].set_title("Task 3: Overall Shift by Bucket") axes[1].legend() for bars in [bars_sum, bars_rate]: for bar in bars: y = bar.get_height() offset = 0.03 if y >= 0 else -0.06 axes[1].text( bar.get_x() + bar.get_width() / 2, y + offset, f"{y:.3f}", ha="center", va="bottom" if y >= 0 else "top", fontsize=8, ) fig.tight_layout() output_path = output_dir / "task3_bucket_deltas.png" fig.savefig(output_path, bbox_inches="tight") plt.close(fig) return output_path def save_compact_snapshot( task1: Optional[Dict[str, Any]], task2: Optional[Dict[str, Any]], task3_gen: Optional[Dict[str, Any]], task3_score: Optional[Dict[str, Any]], output_dir: Path, ) -> Path: snapshot = { "task1": task1, "task2_generation": task2, "task3_generation": task3_gen, "task3_scoring": task3_score, } output_path = output_dir / "metrics_snapshot.json" with open(output_path, "w", encoding="utf-8") as f: json.dump(snapshot, f, indent=2, ensure_ascii=False) return output_path def main(): args = parse_args() output_dir = Path(args.output_dir) output_dir.mkdir(parents=True, exist_ok=True) configure_matplotlib() task1 = load_json(args.task1_test_results) task2 = load_json(args.task2_generation_summary) task3_gen = load_json(args.task3_generation_summary) task3_score = load_json(args.task3_scoring_summary) generated_paths = [] if task1 is not None: path = plot_task1_regression_metrics(task1, output_dir) if path is not None: generated_paths.append(path) if task2 is not None and task3_gen is not None: path = plot_generation_comparison(task2, task3_gen, output_dir) if path is not None: generated_paths.append(path) if task3_score is not None: path = plot_task3_bucket_prediction_sum(task3_score, output_dir) if path is not None: generated_paths.append(path) path = plot_task3_bucket_deltas(task3_score, output_dir) if path is not None: generated_paths.append(path) snapshot_path = save_compact_snapshot(task1, task2, task3_gen, task3_score, output_dir) generated_paths.append(snapshot_path) print("Generated files:") for path in generated_paths: print(f" - {path}") if __name__ == "__main__": main()