original_question stringlengths 21 168 | id stringlengths 11 13 | sentence1 stringlengths 21 168 | sentence2 stringlengths 132 19.7k | label stringclasses 2
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Is the protein Papilin secreted? | converted_0 | Is the protein Papilin secreted? | Using expression analysis, we identify three genes that are transcriptionally regulated by HLH-2: the protocadherin cdh-3, and two genes encoding secreted extracellular matrix proteins, mig-6/papilin and him-4/hemicentin. We found that mig-6 encodes long (MIG-6L) and short (MIG-6S) isoforms of the extracellular matrix... | yes |
Are long non coding RNAs spliced? | converted_1 | Are long non coding RNAs spliced? | Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths. For alternative exons and long noncoding RNAs, splicing tends to occur later, and the latter might remain unspliced in some ca... | yes |
Is RANKL secreted from the cells? | converted_2 | Is RANKL secreted from the cells? | Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily. It usually functions in bone remodeling, by inhibiting osteoclastogenesis thro... | yes |
Does metformin interfere thyroxine absorption? | converted_3 | Does metformin interfere thyroxine absorption? | LT4 absorption is unchanged by concomitant metformin ingestion. It has been hypothesized that metformin may suppress serum thyrotropin (TSH) concentrations by enhancing LT4 absorption or by directly affecting the hypothalamic-pituitary axis.[SEP]Relations: Metformin has relations: contraindication with thymus gland dis... | no |
Has Denosumab (Prolia) been approved by FDA? | converted_4 | Has Denosumab (Prolia) been approved by FDA? | Denosumab is a RANK-ligand antibody that was approved by the FDA in 2010 for the prevention of skeletal fractures in patients with bone metastases from solid tumors. The authors present the imaging findings and technical report of an attempted percutaneous vertebroplasty in the only patient found to be actively under ... | yes |
Are transcription and splicing connected? | converted_5 | Are transcription and splicing connected? | , as splicing is often cotranscriptional, a complex picture emerges in which splicing regulation not only depends on the balance of splicing factor binding to their pre-mRNA target sites but also on transcription-associated features such as protein recruitment to the transcribing machinery and elongation kinetics. rece... | yes |
Is Alu hypomethylation associated with breast cancer? | converted_6 | Is Alu hypomethylation associated with breast cancer? | Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer In IBC, Alu hypomethylation correlated with negative estrogen receptor (ER) status In survival analyses, low Alu methylation status tended to be associated with poor disease-free survival of the patients. Alu hypomethylation is pro... | yes |
Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | converted_7 | Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3). Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a. Here, we described the high quality draft genome sequence, annotations and the features ofArthrobactersp. B6. Complete genome s... | yes |
Do mutations of AKT1 occur in meningiomas? | converted_8 | Do mutations of AKT1 occur in meningiomas? | The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas. A mutation in PIK3CA or AKT1 was found in around 9 % of the cases. AKT1E17K mutations cluster with meningothelial and ... | yes |
Does physical activity influence gut hormones? | converted_9 | Does physical activity influence gut hormones? | Increases in blood PYY(3-36) levels were dependent on the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in GLP-1 levels were similar between two different exercise sessions. A decrease in serum leptin levels (-48.4%, p < 0.001) was observed after intervention without changes in total p... | yes |
Is irritable bowel syndrome more common in women with endometriosis? | converted_10 | Is irritable bowel syndrome more common in women with endometriosis? | CONCLUSIONS: Comorbid pain syndromes, mood conditions and asthma are common in adolescents and young women with endometriosis. There are many etiologies of pelvic pain that present with symptoms resembling those of endometriosis-associated pelvic pain that are not diagnosable with laparoscopy, such as interstitial cyst... | yes |
Does BNP increase after intensive exercise in athletes? | converted_11 | Does BNP increase after intensive exercise in athletes? | NT-pro-BNP was significantly elevated postexercise in both adults and adolescents and remained above baseline at 24 h in both groups. NT-pro-BNP concentrations increased significantly (28 +/- 17.1 vs 795 +/- 823 ng x L, P < 0.05), whereas postrace cTnT were elevated in just five athletes (20%). [NT-pro-BNP] was observe... | yes |
Are there web based self management strategies for chronic pain ? | converted_12 | Are there web based self management strategies for chronic pain ? | Fibromyalgia Symptom Reduction by Online Behavioral Self-monitoring, This study aimed to evaluate effects of a web-based, self-monitoring and symptom management system (SMARTLog) that analyzes personal self-monitoring data and delivers data-based feedback over time. Moderate use (3 times weekly x 3 months) increased l... | yes |
Is Weaver syndrome similar to Sotos? | converted_13 | Is Weaver syndrome similar to Sotos? | Overgrowth conditions are a heterogeneous group of disorders characterised by increased growth and variable features, including macrocephaly, distinctive facial appearance and various degrees of learning difficulties and intellectual disability. Among them, Sotos and Weaver syndromes are clinically well defined and due... | yes |
Is peripheral neuroepithelioma related to Ewing sarcoma? | converted_14 | Is peripheral neuroepithelioma related to Ewing sarcoma? | The term "small round-cell tumor" describes a group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with high nuclear to cytoplasmic ratios. This group includes Ewing's sarcoma (ES), peripheral neuroepithelioma (aka, primitive neuroectodermal tumor or extraskelet... | yes |
Is c-met involved in the activation of the Akt pathway? | converted_15 | Is c-met involved in the activation of the Akt pathway? | Amplification of MET has been reported in approximately 5%-22% of lung tumors with acquired resistance to small-molecule inhibitors of the epidermal growth factor receptor (EGFR). Resistance to EGFR inhibitors is likely mediated through downstream activation of the phosphoinositide 3-kinase /AKT pathway. Simultaneous t... | yes |
Is pregnancy an additional risk during during H1N1 infection? | converted_16 | Is pregnancy an additional risk during during H1N1 infection? | H1N1 influenza in pregnancy can be associated with severe complications This case series confirms a high number of complications in pregnant women due to pandemic H1N1/09. Pregnant women might be at increased risk for complications from pandemic H1N1 virus infection. Pregnant women are at increased risk for complicatio... | yes |
Are long non coding RNAs as conserved in sequence as protein coding genes? | converted_17 | Are long non coding RNAs as conserved in sequence as protein coding genes? | Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally. hey are under stronger selective pressure than neutrally evolving sequences-particularly in their promoter regions, which display levels of selection compa... | no |
Is TENS machine effective in pain? | converted_18 | Is TENS machine effective in pain? | Transcutaneous electrical nerve stimulation is widely used in pain management but its effectiveness depends on the stimulation being targeted appropriately hypoalgesic effects of transcutaneous electrical nerve stimulation upon experimentally induced ischaemic pain. The results of this study have provided evidence of t... | yes |
Is there any algorithm for enhancer identification from chromatin state? | converted_19 | Is there any algorithm for enhancer identification from chromatin state? | RFECS: a random-forest based algorithm for enhancer identification from chromatin state. However, only a limited number of cell types or chromatin marks have previously been investigated for this purpose, leaving the question unanswered whether there exists an optimal set of histone modifications for enhancer predictio... | yes |
Are transcribed ultraconserved regions involved in cancer? | converted_20 | Are transcribed ultraconserved regions involved in cancer? | Although most cancer research has focused in mRNA, non-coding RNAs are also an essential player in tumorigenesis. In addition to the well-recognized microRNAs, recent studies have also shown that epigenetic silencing by CpG island hypermethylation of other classes of non-coding RNAs, such as transcribed ultraconserved ... | yes |
Do patients with Pendred syndrome present congenital deafness? | converted_21 | Do patients with Pendred syndrome present congenital deafness? | Pendred Syndrome can be characterized by the triad composed of familial goitre, abnormal perchlorate discharge and congenital deafness. Pendred syndrome is an autosomal recessive disorder characterized by congenital deafness and goiter. Pendred syndrome comprises congenital sensorineural hearing loss, thyroid goiter, ... | yes |
Is CD56 useful in Ewing sarcoma prognosis? | converted_22 | Is CD56 useful in Ewing sarcoma prognosis? | Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry There was a highly significant correlation between CD56 expression and progression-free survival (PFS; 69% in low/negative expression versus 30% in high expression groups, P = 0.024) In patients with loca... | yes |
Are there any urine biomarkers for chronic kidney disease? | converted_23 | Are there any urine biomarkers for chronic kidney disease? | Kidney and urine proteomic biomarkers are considered as promising diagnostic tools to predict CKD progression early in diabetic nephropathy, facilitating timely and selective intervention that may reduce the related health-care expenditures. Both blood and urine biomarkers are reviewed in this paper and offer a conside... | yes |
Is valproic acid effective for glioblastoma treatment? | converted_24 | Is valproic acid effective for glioblastoma treatment? | A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma. PURPOSE: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in precli... | yes |
Can Levoxyl (levothyroxine sodium) cause insomnia? | converted_25 | Can Levoxyl (levothyroxine sodium) cause insomnia? | METHODS: Seventy-one patients diagnosed with primary hypothyroidism were randomly allocated into two study groups: the first group received usual dose of levothyroxine and the second group received combination of levothyroxine and liothyronine for at least 4 months. The main outcomes were psychosocial problems (Goldber... | yes |
Is fatigue prevalent in patients receiving treatment for glioblastoma? | converted_26 | Is fatigue prevalent in patients receiving treatment for glioblastoma? | By contrast, fatigue worsened over time, with a difference in mean score of 5.6 points between baseline and 4-month follow-up (P=.02). In the GB cohort, the most common side effects were fatigue (56 %), diarrhea (44 %), neutropenia (31 %), and thrombocytopenia (25 %). A total of 37 patients were treated, and treatment... | yes |
Does the CTCF protein co-localize with cohesin? | converted_27 | Does the CTCF protein co-localize with cohesin? | To investigate cohesin-non-CTCF (CNC) binding events in vivo we mapped cohesin and CTCF, as well as a collection of tissue-specific and ubiquitous transcriptional regulators using ChIP-seq in primary mouse liver. In contrast to regions of the genome where cohesin and CTCF colocalize, CNC sites coincide with the binding... | yes |
Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | converted_28 | Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | SGs have been linked to several pathologies including inflammatory diseases, cancer, viral infection, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Like several other ALS-associated proteins, CREST is recruited to induced stress granules. Our data indicate... | yes |
Does TGF-beta play a role in cardiac regeneration after myocardial infarction? | converted_29 | Does TGF-beta play a role in cardiac regeneration after myocardial infarction? | We then performed a chemical screen and identified several small molecules that increase or reduce cardiomyocyte proliferation during heart development. These compounds act via Hedgehog, Insulin-like growth factor or Transforming growth factor β signaling pathways. Here, we report that the balance between the reparati... | yes |
Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | converted_30 | Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | DITPA normalized the elevated serum T(3) and TSH when the dose reached 1 mg/kg · d and T(4) and rT(3) increased to the lower normal range. The identification of 3,5-diiodothyropropionic acid (DITPA) that binds to both α- and β-type TRs with relatively low affinity was unique in that this analog improves left ventricula... | yes |
Is MammaPrint cleared by the United States Food and Drug Administration? | converted_31 | Is MammaPrint cleared by the United States Food and Drug Administration? | Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX recurrence score assay panel.[SEP]Relations: salivary gland type cancer of the breast has relations: disease_disease with breast cancer, disease_disease with br... | yes |
Is amantadine effective for treatment of disorders conciousness? | converted_32 | Is amantadine effective for treatment of disorders conciousness? | We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from coma. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, leading sometimes to dramatic ... | yes |
Is GAGA associated with nucleosome-free regions (NFR)? | converted_33 | Is GAGA associated with nucleosome-free regions (NFR)? | One of the three nuclease hypersensitive sites in the Fab-7 boundary, HS1, contains multiple consensus-binding sequences for the GAGA factor, a protein known to be involved in the formation and/or maintenance of nucleosome-free regions of chromatin. The HS3 sequence contains consensus binding sites for the GAGA factor,... | yes |
Is amiodarone a class I anti-arrhythmic drug? | converted_34 | Is amiodarone a class I anti-arrhythmic drug? | Common class I agents are excluded due to the inherent abnormal cardiac structure and function in the setting of cardiogenic shock. Class III drug options include dofetilide and amiodarone. Amiodarone has been used as an anti-arrhythmic drug since the 1970s and has an established role in the treatment of ventricular ta... | no |
Has the protein TIEG1 been associated with apoptosis? | converted_35 | Has the protein TIEG1 been associated with apoptosis? | TGF-beta) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-beta sensitive pancreatic cancer cells, yet its effect on TGF-beta resistant cancer cells remains unclear overexpression of TIEG1, protected ALL cells against chemotherapy-induced cell death TIEG1 might be involved in mediating this effect fr... | yes |
Is PTEN involved in follicular thyroid carcinoma? | converted_36 | Is PTEN involved in follicular thyroid carcinoma? | Two of the 259 patients (0.8%), with both follicular thyroid carcinoma and macrocephaly, were found to carry a germline mutation in the PTEN gene. The PTEN mutation frequency in unselected cases of follicular thyroid carcinoma was 4.8% The frequency of germline pathogenic PTEN mutations in an unselected series of patie... | yes |
Does strenuous physical activity affect thyroid hormone metabolism? | converted_37 | Does strenuous physical activity affect thyroid hormone metabolism? | The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T(3) syndrome 3,5,3'-tr... | yes |
Is the gene MAOA epigenetically modified by methylation? | converted_38 | Is the gene MAOA epigenetically modified by methylation? | Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. We found significant interindividual differences in methylation status and methylation patterns of the core MAOA promoter. In the present study, DNA methylation patterns in the MAOA regula... | yes |
Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | converted_39 | Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | Charcot-Marie-Tooth disease type 2D (CMT2D) is an autosomal-dominant axonal peripheral neuropathy characterized by impaired motor and sensory function in the distal extremities. Mutations in the glycyl-tRNA synthetase (GARS) gene cause CMT2D Dominant mutations in GARS cause rare forms of Charcot-Marie-Tooth disease and... | yes |
Is there any software for automated analysis of FISH images? | converted_40 | Is there any software for automated analysis of FISH images? | he study demonstrated the feasibility of automated FISH signal analysis that applying a CAD scheme to the automated generated 2-D projection images. A color imaging technique, multiplex fluorescent in situ hybridization (M-FISH), has been developed to ease the analysis of the process. Using an M-FISH technique each chr... | yes |
Is there an increased risk for cancer in Dyskeratosis Congenita? | converted_41 | Is there an increased risk for cancer in Dyskeratosis Congenita? | People with DC are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML), solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis Clinical progression of the disease can lead to aplastic anemia... | yes |
Does MicroRNA-21 (miR-21) contribute to cardiovascular disease? | converted_42 | Does MicroRNA-21 (miR-21) contribute to cardiovascular disease? | The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis. Taken together, we found a novel reciprocal loop between miR-21 and TGFβRIII in cardiac fibrosis caused by myocardial infarction in mice, and targeting this ... | yes |
Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | converted_43 | Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries. In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize ChIP-seq data, and to find differential regions in the genome, given two libraries of histone modificatio... | yes |
Is CD84 genetically associated with arthritis? | converted_44 | Is CD84 genetically associated with arthritis? | The SNP is predicted to disrupt transcription factor binding site motifs in the 3' UTR of an immune-related gene, CD84, and the allele associated with better response to etanercept was associated with higher CD84 gene expression in peripheral blood mononuclear cells (P = 1 × 10(-11) in 228 non-RA patients and P = 0.004... | yes |
Are there any specific antidotes for rivaroxaban? | converted_45 | Are there any specific antidotes for rivaroxaban? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. h... | no |
Is cytisine superior to nicotine replacement therapy for smoking cessation? | converted_46 | Is cytisine superior to nicotine replacement therapy for smoking cessation? | The effectiveness of cytisine for continuous abstinence was superior to that of nicotine-replacement therapy at 1 week, 2 months, and 6 months. In a prespecified subgroup analysis of the primary outcome, cytisine was superior to nicotine-replacement therapy among women and noninferior among men. CONCLUSIONS: When combi... | yes |
Is the abnormal dosage of ultraconserved elements disfavored in cancer cells? | converted_47 | Is the abnormal dosage of ultraconserved elements disfavored in cancer cells? | Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells. We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are significa... | no |
Does thyroid hormone regulate calcium transient in the myocardium? | converted_48 | Does thyroid hormone regulate calcium transient in the myocardium? | 3-iodothyronamine (T(1)AM) is a novel endogenous relative of thyroid hormone, able to interact with trace amine-associated receptors, a class of plasma membrane G protein-coupled receptors, and to produce a negative inotropic and chronotropic effect In adult rat cardiomyocytes acute exposure to 20 microM T(1)AM decreas... | yes |
Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | converted_49 | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target We further found that ATO ta... | yes |
Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | converted_50 | Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | Our results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring These data defined two cohesion pathways, one containing CSM3, TOF1, CTF4, and CHL1, and the second containing MRC1, CTF18, CTF8, and DCC1 Here we show that three proteins require... | yes |
Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | converted_51 | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | This study reports the consequences of LT4 treatment over a prolonged period of time in 2 of the first patients with a heterozygous mutation in TRα1. Here we show that the dysregulation of the pituitary-thyroid axis was worsened by the lack of TR alpha1 in TR betaPV mice, and severe impairment of postnatal growth was m... | yes |
Does administration of triiodothyronine improve outcome following coronary artery bypass grafting? | converted_52 | Does administration of triiodothyronine improve outcome following coronary artery bypass grafting? | Serum T3 concentrations were significantly higher with fewer patients having T3 concentrations below the normal range in the T3 group than the placebo group throughout the postoperative period. Hemodynamic variables, postoperative inotrope requirement, and outcome variables showed no differences between the groups We c... | no |
Is long QT syndrome a cause for sudden cardiac death in athletes? | converted_53 | Is long QT syndrome a cause for sudden cardiac death in athletes? | A diversity of cardiovascular disorders including hypertrophic cardiomyopathy, congenital coronary anomalies, arrhythmogenic right ventricular dysplasia, dilated cardiomyopathy, aortic rupture due to Marfan syndrome, myocarditis, valvular disease and electrical disorders (Wolff-Parkinson-White syndrome, long QT syndrom... | yes |
Is protein M3/6 a dual specificity phosphatase? | converted_54 | Is protein M3/6 a dual specificity phosphatase? | Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus. The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4 h of reperfusion in rat hippocampi. This study examines the molecular mechanism u... | yes |
Are there focused databases from which you can retrieve gene expression data on renal disease? | converted_55 | Are there focused databases from which you can retrieve gene expression data on renal disease? | Proteomics database in chronic kidney disease Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease[SEP]Relations: Chronic kidney disease has relations: disease_phenotype_positive with glycogen storage disease, disease_phenotype_positive with glycogen storage disease, disease_phenoty... | yes |
Are there any DNMT3 proteins present in plants? | converted_56 | Are there any DNMT3 proteins present in plants? | De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3. Here we describe DNA methyltransferase genes from both Arabidopsis and maize that show a high level of sequence similarity to Dnmt3, suggesting that they encode plant d... | yes |
Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | converted_57 | Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | However, apart from the beneficial effects of 800 IU/d of vitamin D3 for reduction of falls in the elderly, causality remains yet unproven in randomized controlled trials (RCTs). The rate of falls and the number of fallers was significantly reduced in two studies evaluating the effect of medication on preventing falls... | yes |
Has depression been shown to be a predictor of frailty? | converted_58 | Has depression been shown to be a predictor of frailty? | significant role of frailty as a predictor of depression in a relatively younger old Chinese population significant relationships between frailty and depressive symptoms and mortality at 1 year These findings suggest that malnutrition is a major predictor of frailty or the "failure to thrive" syndrome in older persons.... | yes |
Is there any association between Jarid2 and miR-155 in Th17 cells? | converted_59 | Is there any association between Jarid2 and miR-155 in Th17 cells? | Jarid2 links MicroRNA and chromatin in Th17 cells. In this issue of Immunity, Escobar et al. (2014) bring microRNAs and chromatin together by showing how activation-induced miR-155 targets the chromatin protein Jarid2 to regulate proinflammatory cytokine production in T helper 17 cells. miR-155 activates cytokine gene ... | yes |
Is it safe to take isotretinoin during pregnancy? | converted_60 | Is it safe to take isotretinoin during pregnancy? | Isotretinoin is a remarkably effective drug for severe, recalcitrant acne vulgaris. a number of important adverse effects were reported even the most recent pregnancy prevention program (iPledge) is no more successful than prior programs; there will likely always be a small number of female patients becoming pregnant w... | no |
Can DNA intercalators function as topoisomerase inhibitors? | converted_61 | Can DNA intercalators function as topoisomerase inhibitors? | The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding a... | yes |
Do orphan and gene related CpG islands follow power-law-like distributions? | converted_62 | Do orphan and gene related CpG islands follow power-law-like distributions? | Orphan and gene related CpG Islands follow power-law-like distributions in several genomes: evidence of function-related and taxonomy-related modes of distribution. Here, an investigation of their distributional characteristics in a variety of genomes is undertaken for both whole CGI populations as well as for CGI subs... | yes |
Can valproic acid act as an activator of AMPK? | converted_63 | Can valproic acid act as an activator of AMPK? | Here we demonstrate that VPA is a novel activator of AMP-activated protein kinase (AMPK), a key regulator of cellular metabolism, using primary mouse and human hepatocytes. These studies are the first to establish VPA and its metabolites as in vitro activators of AMPK.[SEP]Relations: Valproic acid has relations: drug_d... | yes |
Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | converted_64 | Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | Gene regulation in Drosophila spermatogenesis: analysis of protein binding at the translational control element TCE. We have previously identified a 12 nucleotide long sequence element, the TCE, that was demonstrated to be necessary for translational control of expression in the male germ line of Drosophila melanogaste... | yes |
Is low T3 syndrome a prognostic marker in patients with renal insufficiency? | converted_65 | Is low T3 syndrome a prognostic marker in patients with renal insufficiency? | Low T3 was particularly common (44.3 %), and clearly associated with increased 6- and 12-month mortality and decreased overall survival (log rank test, P=0.007). Increased rT3 may be more common in ESRD patients than previously described, and together with decreased T3 it may serve as an indicator of poor prognosis in... | yes |
Does burning mouth syndrome preferentially affect post-mepopausal women? | converted_66 | Does burning mouth syndrome preferentially affect post-mepopausal women? | It is observed principally in middle-aged patients and postmenopausal women and may be accompanied by xerostomia and altered taste. It occurs more commonly in middle-aged and elderly women and often affects the tongue tip and lateral borders, lips, and hard and soft palate. BMS is a chronic disorder that frequently af... | yes |
Can life style changes reduce oxidative stress | converted_67 | Can life style changes reduce oxidative stress | The CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis. Antioxidant treatment and life style changes are indicated ... | yes |
Is oxidative stress affected by FOXO expression? | converted_68 | Is oxidative stress affected by FOXO expression? | Forkhead-box class O (FoxO) transcription factors regulate mechanisms of cellular aging, including protein quality control, autophagy and defenses against oxidative stress. Statin-mediated upregulation of klotho expression and differential regulation of FoxO expression promote resistance to CsA-induced oxidative stress... | yes |
Is the Dictyostelium discoideum proteome known? | converted_69 | Is the Dictyostelium discoideum proteome known? | The Negative Proteome Database (NPD) is populated with pair-wise protein sequence comparisons between each of the following proteomes: Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Dictyostelium discoideum, Chlamydomonus reinhardti, Escherichia coli K12, Arabidop... | yes |
Is single-cell analysis (SCA) possible in proteomics? | converted_70 | Is single-cell analysis (SCA) possible in proteomics? | Toward Single Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry. he advent of proteomics and genomics at a single-cell level has set the basis for an outstanding improvement in analytical technology and data acquisition. The new-generation technology of single-cell analysis ... | no |
Is shotgun lipidomics the direct infusion of a lipid sample into a mass spectrometer? | converted_71 | Is shotgun lipidomics the direct infusion of a lipid sample into a mass spectrometer? | In direct infusion/injection (or shotgun) lipidomics An efficient shotgun lipidomics strategy was established and optimized for fast phospholipid profiling of viscera from three fish species: Lateolabrax japonicas, Ctenopharyngodon idellus, and Carassius auratus. This strategy relies on direct infusion of total lipid e... | yes |
Is apixaban effective for treatment of acute venous thromboembolism? | converted_72 | Is apixaban effective for treatment of acute venous thromboembolism? | Apixaban is a direct inhibitor of factor Xa, and is a potential alternative for the treatment of acute venous thromboembolism. These results suggest a lack of clear superiority of apixaban relative to enoxaparin. Apixaban is an oral alternative with similar efficacy and safety to existing anticoagulant therapies. A fi... | yes |
Is the tricarboxylic acid (TCA) cycle affected in inflammation? | converted_73 | Is the tricarboxylic acid (TCA) cycle affected in inflammation? | In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (UC) were profiled by gas chromatography/mass spectrometry (GC/MS), with the aim of evaluating whether the clinical state induced by UC leads to variations ... | yes |
Are reduced-nicotine cigarettes effective for smoking cessation? | converted_74 | Are reduced-nicotine cigarettes effective for smoking cessation? | CONCLUSIONS: In this 6-week study, reduced-nicotine cigarettes versus standard-nicotine cigarettes reduced nicotine exposure and dependence and the number of cigarettes smoked. RESULTS: Significant reductions in nicotine intake were observed between usual brand smoking (∼1.2 mg nicotine) and the 0.3 and 0.05 mg nicoti... | yes |
Is the Wnt protein modified by notum? | converted_75 | Is the Wnt protein modified by notum? | Notum deacylates Wnt proteins to suppress signalling activity. Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase. the Wnt inhibitor notum the... | yes |
Is ospemifene effective for treatment of dyspareunia? | converted_76 | Is ospemifene effective for treatment of dyspareunia? | Ospemifene, a novel selective estrogen receptor modulator, has been developed for the treatment of vulvovaginal atrophy and dyspareunia in postmenopausal women. For the comparison of short-term ospemifene with placebo, parabasal cells (the standardized mean difference [SMD] = -37.5, 95% confidence interval [CI] = -41.... | yes |
Is pregabalin effective for treatment of patients with restless leg syndrome? | converted_77 | Is pregabalin effective for treatment of patients with restless leg syndrome? | CONCLUSIONS: This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole. Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole. CONCLUSIONS: Pregabalin provided signif... | yes |
Can zinc finger nucleases be used to combat disease? | converted_78 | Can zinc finger nucleases be used to combat disease? | Genetic engineering has emerged as a powerful mechanism for understanding biological systems and a potential approach for redressing congenital disease. This is of particular importance, given the momentum currently behind ZFNs in moving into phase I clinical trials. This study provides a historical account of the orig... | yes |
Is RET the major gene involved in Hirschsprung disease? | converted_79 | Is RET the major gene involved in Hirschsprung disease? | The RET proto-oncogene is the major gene associated to HSCR with differential contributions of its rare and common, coding and noncoding mutations to the multifactorial nature of this pathology The RET proto-oncogene is the major gene for HSCR with differential contributions of its rare and common, coding and noncoding... | yes |
is intense physical activity associated with longevity ? | converted_80 | is intense physical activity associated with longevity ? | We found a very significant increase in average longevity (17%) of the cyclists when compared with the general population. The age at which 50% of the general population died was 73.5 vs. 81.5 years in Tour de France participants. Our major finding is that repeated very intense exercise prolongs life span in well train... | yes |
Are cyclophilins proteins that bind to prolines? | converted_81 | Are cyclophilins proteins that bind to prolines? | Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyse cis/trans isomerization of proline residues. a characteristic of the cyclophilin family of proteins that bind prolines and often act as cis-trans peptidyl-prolyl isomerases. The cyclophilins are widely expressed enzymes that cataly... | yes |
Can a given genotype exhibit opposite fitness effects (beneficial and detrimental) within the same environment? | converted_82 | Can a given genotype exhibit opposite fitness effects (beneficial and detrimental) within the same environment? | Mutations beneficial in one environment may cause costs in different environments, resulting in antagonistic pleiotropy. Here, we describe a novel form of antagonistic pleiotropy that operates even within the same environment, where benefits and deleterious effects exhibit themselves at different growth rates. The hfq ... | yes |
Has the protein SETMAR (Metnase) a transposase domain? | converted_83 | Has the protein SETMAR (Metnase) a transposase domain? | Metnase (SETMAR) is a SET-transposase fusion protein that promotes nonhomologous end joining (NHEJ) repair in humans. The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. Metnase (also termed SETMAR) is a fusion of a histone methylase and transposase protein that arose specifically in p... | yes |
Is nucleosome eviction ATP-dependent? | converted_84 | Is nucleosome eviction ATP-dependent? | ATP-dependent chromatin remodeling and nucleosome-depleted 'barriers' co-operate to determine the kinetics of nucleosome organization ATP-dependent nucleosome-remodeling factors endow chromatin with structural flexibility by promoting assembly or disruption of nucleosomes and the exchange of histone variants. remodelin... | yes |
Is TREM2 associated with Alzheimer's disease in humans? | converted_85 | Is TREM2 associated with Alzheimer's disease in humans? | Genetic deficits and loss of function for the triggering receptor expressed in myeloid cells 2 (TREM2; encoded at chr6p21.1), a transmembrane spanning stimulatory receptor of the immunoglobulin/lectin-like gene superfamily, have been associated with deficiencies in phagocytosis and the innate immune system in Alzheimer... | yes |
Have mutations in the Polycomb group been found in human diseases? | converted_86 | Have mutations in the Polycomb group been found in human diseases? | We identify a novel mutation in PHC1, a human orthologue of the Drosophila polyhomeotic member of polycomb group (PcG), which significantly decreases PHC1 protein expression, increases Geminin protein level and markedly abolishes the capacity to ubiquitinate histone H2A in patient cells. In clinical specimens of head a... | yes |
Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | converted_87 | Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. I In addition, miR-21, -24, -133, -210, -494, and -499 appear to protect myocytes against I/R-induced apoptosis, whereas miR... | yes |
Can sorafenib activate AMPK? | converted_88 | Can sorafenib activate AMPK? | Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. Persistent activation of AMPK by sorafenib finally led to the impairment of glucose metabolism both in MCF-7 and SKBR3 cells as well as in the highly glycolytic MDA-MB-231 cells... | yes |
Is Vortioxetine effective for treatment of depression? | converted_89 | Is Vortioxetine effective for treatment of depression? | Vortioxetine is an orally administered small molecule developed by Lundbeck A/S for the once-daily treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD). Vortioxetine received its first global approval for MDD in the USA in September 2013 and regulatory approval for its use in this indicat... | yes |
Is exome sequencing efficient for the detection of germline mutations? | converted_90 | Is exome sequencing efficient for the detection of germline mutations? | Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas Whole exome sequencing is sensitive, rapid and efficient for detection of PCC/PGL germline mutations. These results from deep sequencing demonstrate a higher mutational d... | yes |
Is it feasible to determine the complete proteome of yeast? | converted_91 | Is it feasible to determine the complete proteome of yeast? | or model organisms like yeast, we can now quantify complete proteomes in just a few hours. A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis. So far, attempts to generate such maps for any proteome have failed to reach complete proteome coverage. Here we use a strategy based... | yes |
Are circRNAs associated with diseases and traits? | converted_92 | Are circRNAs associated with diseases and traits? | Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits. Circular RNAs play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. Their interaction with disease associated miRNAs indicates that circular RNAs are ... | yes |
Could the Menzerath-Altmann law be proved mathematically trivial in genomes? | converted_93 | Could the Menzerath-Altmann law be proved mathematically trivial in genomes? | Here we review the statistical foundations of that test and consider three non-parametric tests based upon different correlation metrics and one parametric test to evaluate if Z ∼ 1/X in genomes. The most powerful test is a new non-parametric one based upon the correlation ratio, which is able to reject Z ∼ 1/X in nine... | yes |
Are there studies representing the involvement of Notch mutations in neurodegenerative diseases such as Down syndrome, Pick's and Prion's disease, and cadasil syndrome? | converted_94 | Are there studies representing the involvement of Notch mutations in neurodegenerative diseases such as Down syndrome, Pick's and Prion's disease, and cadasil syndrome? | he Notch signaling pathway plays a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis, and is a highly conserved signaling pathway that regulates normal development in a context- and dose-dependent manner. Dysregulation of Notch signaling has been suggested to be key even... | yes |
Are there any functional differences between Mfd and its human Cocaine syndrome protein B (CSB) homolog? | converted_95 | Are there any functional differences between Mfd and its human Cocaine syndrome protein B (CSB) homolog? | In humans, the TCR coupling factor, CSB, plays a critical role in restoring transcription following both UV-induced and oxidative DNA damage. It also contributes indirectly to the global repair of some forms of oxidative DNA damage. The Escherichia coli homolog, Mfd, is similarly required for TCR of UV-induced lesions.... | yes |
Is the yeast Μac1 transcription factor induced upon copper deficiency? | converted_96 | Is the yeast Μac1 transcription factor induced upon copper deficiency? | Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces cerevisiae. The copper-depletion induced CTR2 transcription can be abrogated by genetic deletion of copper-sensing transcription factor Mac1p Taken together, our results suggest that Mac1p can activate the ex... | yes |
Have thyronamines effects on fat tissue? | converted_97 | Have thyronamines effects on fat tissue? | In conclusion, trace amines and thyronamines are negative inotropic agents. Their in vivo administration induces effects opposite to those induced by thyroid hormone, including lowering of body temperature.[SEP]Relations: response to thyroid hormone has relations: bioprocess_protein with GBA, bioprocess_protein with GB... | no |
Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | converted_98 | Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its combination with the curren... | yes |
Is there an association between TERT promoter mutation and survival of glioblastoma patients? | converted_99 | Is there an association between TERT promoter mutation and survival of glioblastoma patients? | Glioblastoma patients with TERT mutations showed a shorter survival than those without TERT mutations in univariate analysis (median, 9.3 vs. 10.5 months; P = 0.015) and multivariate analysis after adjusting for age and gender (HR 1.38, 95 % CI 1.01-1.88, P = 0.041). However, TERT mutations had no significant impact on... | yes |
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