original_question stringlengths 21 168 | id stringlengths 11 13 | sentence1 stringlengths 26 211 | sentence2 stringlengths 132 24k | label stringclasses 2
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Is the protein Papilin secreted? | converted_0 | Is the protein Papilin secreted? | Using expression analysis, we identify three Genes that are transcriptionally regulated by HLH-2: the PROTOCADHERIN 3 cdh-3, and two Genes encoding secreted Extracellular Matrix Proteins, ERBB Receptor Feedback Inhibitor 1/papilin and him-4/hemicentin. We found that ERBB Receptor Feedback Inhibitor 1 encodes long (MIG... | yes |
Are long non coding RNAs spliced? | converted_1 | Are long non coding RNAs spliced? | Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths. For alternative exons and long noncoding RNAs, splicing tends to occur later, and the latter might remain unspliced in some ca... | yes |
Is RANKL secreted from the cells? | converted_2 | Is TNFSF11 protein, human wt Allele secreted from the Cells? | Osteoprotegerin (Panoramic Radiography) is a soluble secreted factor that acts as a TNFRSF10C gene for receptor activator of NF-κB ligand (TNFSF11 protein, human protein, human wt Allele) Osteoprotegerin (Panoramic Radiography) is a secreted glycoprotein and a member of the Tumor Necrosis Factor Receptor superfamily. ... | yes |
Does metformin interfere thyroxine absorption? | converted_3 | Does metformin interfere thyroxine absorption? | LT4 absorption is unchanged by concomitant metformin ingestion. It has been hypothesized that metformin may suppress serum thyrotropin (TSH) concentrations by enhancing LT4 absorption or by directly affecting the hypothalamic-pituitary axis.[SEP]Relations: Metformin has relations: contraindication with thymus gland dis... | no |
Has Denosumab (Prolia) been approved by FDA? | converted_4 | Has Denosumab (Prolia) been approved by FDA? | Denosumab is a RANK-ligand antibody that was approved by the FDA in 2010 for the prevention of skeletal fractures in patients with bone metastases from Solid Neoplasm. The authors present the imaging findings and technical report of an attempted percutaneous vertebroplasty in the only patient found to be actively unde... | yes |
Are transcription and splicing connected? | converted_5 | Are transcription and splicing connected? | , as splicing is often cotranscriptional, a complex picture emerges in which splicing regulation not only depends on the balance of RNA Splicing Factors binding to their mRNA Precursor target sites but also on transcription-associated features such as Protein Info recruitment to the transcribing machinery and elongatio... | yes |
Is Alu hypomethylation associated with breast cancer? | converted_6 | Is Alu hypomethylation associated with Malignant neoplasm of Breast? | Alu and Long Interspersed Nucleotide Element-1 hypomethylation is associated with ERBB2 wt Allele enriched subtype of Malignant neoplasm of Breast In IBC, Alu hypomethylation correlated with negative Estrogen Receptors (Endoplasmic Reticulum) status In survival analyses, low Alu methylation status tended to be associat... | yes |
Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | converted_7 | Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3). Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a. Here, we described the high quality draft genome sequence, annotations and the features ofArthrobactersp. B6. Complete genome s... | yes |
Do mutations of AKT1 occur in meningiomas? | converted_8 | Do Gene Mutation of AKT1 protein, human occur in Meningioma? | The recent identification of somatic Gene Mutation in components of the SHH-GLI1 and AKT1 protein, human protein, human-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of Meningioma. A Mutation Abnormality in PIK3CA gene gene or AKT1 protein, human protein, human was ... | yes |
Does physical activity influence gut hormones? | converted_9 | Does physical activity influence gut hormones? | Increases in blood Peptide YY, human(3-36) levels were dependent on the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in Glucagon-Like Peptide 1 levels were similar between two different exercise sessions. A decrease in serum leptin levels (-48.4%, p < 0.001) was observed after interve... | yes |
Is irritable bowel syndrome more common in women with endometriosis? | converted_10 | Is Irritable Bowel Syndrome more common in women with Endometriosis? | CONCLUSIONS: Comorbid pain syndromes, mood conditions and Asthma are common in adolescents and young women with Endometriosis. There are many etiologies of Pelvic pain female that present with symptoms resembling those of Endometriosis-associated Pelvic pain female that are not diagnosable with laparoscopy, such as Chr... | yes |
Does BNP increase after intensive exercise in athletes? | converted_11 | Does nesiritide increase after intensive exercise in athletes? | NT-pro-nesiritide was significantly elevated postexercise in both adults and adolescents and remained above baseline at 24 h in both groups. NT-pro-nesiritide concentrations increased significantly (28 +/- 17.1 vs 795 +/- 823 ng x L, P < 0.05), whereas postrace Troponin T, Cardiac Muscle were elevated in just five athl... | yes |
Are there web based self management strategies for chronic pain ? | converted_12 | Are there web based self management strategies for Chronic Pain:-:Point in time:^Patient:- ? | Fibromyalgia Symptom Reduction by Online Behavioral Self-monitoring, This study aimed to evaluate effects of a web-based, self-monitoring and symptom management system (SMARTLog) that analyzes personal self-monitoring data and delivers data-based feedback over time. Moderate use (3 times weekly x 3 months) increased l... | yes |
Is Weaver syndrome similar to Sotos? | converted_13 | Is Weaver syndrome similar to Sotos? | Overgrowth conditions are a heterogeneous group of disorders characterised by increased growth and variable features, including Macrocephaly, distinctive facial appearance and various degrees of Learning difficulties and Intellectual Disability. Among them, Sotos and Weaver syndromes are clinically well defined and due... | yes |
Is peripheral neuroepithelioma related to Ewing sarcoma? | converted_14 | Is Peripheral Neuroectodermal Tumor, Primitive related to Ewing sarcoma? | The term "small round-cell tumor" describes a group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with high Nuclear (incident type) to cytoplasmic ratios. This group includes Ewing's sarcoma of bone of Specimen Type - Bone (ES), Peripheral Neuroectodermal Tumor... | yes |
Is c-met involved in the activation of the Akt pathway? | converted_15 | Is c-met involved in the activation of the Proto-Oncogene Proteins c-akt pathway? | Amplification of methionine has been reported in approximately 5%-22% of Lung Neoplasms with acquired resistance to small-molecule inhibitors of the epidermal growth factor receptor (Epidermal Growth Factor Receptor). Resistance to Epidermal Growth Factor Receptor inhibitors is likely mediated through downstream activa... | yes |
Is pregnancy an additional risk during during H1N1 infection? | converted_16 | Is pregnancy an additional risk during during H1N1 Communicable Diseases? | H1N1 influenza in pregnancy can be associated with severe complications This case series confirms a high number of complications in pregnant women due to pandemic H1N1/09. Pregnant women might be at increased risk for complications from pandemic H1N1 Virus Communicable Diseases. Pregnant women are at increased risk for... | yes |
Are long non coding RNAs as conserved in sequence as protein coding genes? | converted_17 | Are long non coding RNAs as conserved in sequence as protein coding genes? | Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally. hey are under stronger selective pressure than neutrally evolving sequences-particularly in their Promoter Regions, Genetic, which display levels of select... | no |
Is TENS machine effective in pain? | converted_18 | Is Transcutaneous Electric Nerve Stimulation machine effective in pain? | Transcutaneous electrical nerve stimulation is widely used in pain management but its effectiveness depends on the stimulation being targeted appropriately hypoalgesic effects of transcutaneous electrical nerve stimulation upon experimentally induced ischaemic pain. The results of this study have provided evidence of t... | yes |
Is there any algorithm for enhancer identification from chromatin state? | converted_19 | Is there any algorithm for Enhancer of transcription identification from chromatin state? | RFECS: a random-forest based algorithm for Enhancer of transcription identification from chromatin state. However, only a limited number of cell types or chromatin marks have previously been investigated for this purpose, leaving the question unanswered whether there exists an optimal set of Histone antigen modificatio... | yes |
Are transcribed ultraconserved regions involved in cancer? | converted_20 | Are transcribed ultraconserved regions involved in cancer? | Although most cancer research has focused in RNA, Messenger, non-coding RNAs are also an essential player in tumorigenesis. In addition to the well-recognized microRNAs, recent studies have also shown that epigenetic silencing by CpG Islands hypermethylation of other classes of non-coding RNAs, such as transcribed ultr... | yes |
Do patients with Pendred syndrome present congenital deafness? | converted_21 | Do patients with Pendred's syndrome present Congenital Hearing Loss, Partial? | Pendred Syndrome can be characterized by the triad composed of familial goitre, abnormal perchlorate discharge and Congenital Hearing Loss, Partial. Pendred's syndrome is an Autosomal Recessive Disorder characterized by Congenital Hearing Loss, Partial and goiter. Pendred's syndrome comprises congenital sensorineural ... | yes |
Is CD56 useful in Ewing sarcoma prognosis? | converted_22 | Is NCAM1 wt Allele useful in Ewings sarcoma prognosis? | Excellent prognosis in a subset of patients with Ewings sarcoma identified at diagnosis by NCAM1 wt Allele using flow cytometry There was a highly significant correlation between NCAM1 wt Allele expression and progression-free survival (PFS; 69% in low/negative expression versus 30% in high expression groups, P = 0.024... | yes |
Are there any urine biomarkers for chronic kidney disease? | converted_23 | Are there any urine biomarkers for chronic Both kidneys disease? | Kidney and urine proteomic biomarkers are considered as promising diagnostic tools to predict CKD progression early in Diabetic Nephropathy, facilitating timely and selective intervention that may reduce the related health-care expenditures. Both blood and urine biomarkers are reviewed in this paper and offer a conside... | yes |
Is valproic acid effective for glioblastoma treatment? | converted_24 | Is valproic acid effective for glioblastoma treatment? | A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma Multiforme Multiforme. PURPOSE: valproic acid (VPA) is an antiepileptic agent with Histone Deacetylase Inhibitor [EPC] therapy (HDACi) activity shown to sensitize glioblastom... | yes |
Can Levoxyl (levothyroxine sodium) cause insomnia? | converted_25 | Can Levoxyl (levothyroxine sodium) cause insomnia? | METHODS: Seventy-one patients diagnosed with Acquired hypothyroidism were randomly allocated into two study groups: the first group received usual dose of levothyroxine and the second group received combination of levothyroxine and liothyronine for at least 4 months. The main outcomes were psychosocial problems (Goldbe... | yes |
Is fatigue prevalent in patients receiving treatment for glioblastoma? | converted_26 | Is fatigue prevalent in patients receiving treatment for glioblastoma? | By contrast, fatigue worsened over time, with a difference in mean score of 5.6 points between baseline and 4-month follow-up (P=.02). In the GB cohort, the most common side effects were fatigue (56 %), Diarrhea (44 %), Neutrophil count decreased (31 %), and THROMBOCYTOPENIA 2 (disorder) (25 %). A total of 37 patients... | yes |
Does the CTCF protein co-localize with cohesin? | converted_27 | Does the CTGF protein, Homo sapiens protein co-localize with cohesins? | To investigate cohesins-non-CTGF protein, Homo sapiens (CNC) binding events in vivo we mapped cohesins and CTGF protein, Homo sapiens, as well as a collection of tissue-specific and ubiquitous transcriptional regulators using Chromatin Immunoprecipitation Sequencing in primary Mus sp. liver. In contrast to regions of t... | yes |
Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | converted_28 | Are Stress Granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | Shprintzen-Goldberg syndrome have been linked to several pathologies including inflammatory diseases, Primary malignant neoplasm, Virus Diseases, and Neurodegenerative Disorders such as AMYOTROPHIC LATERAL SCLEROSIS 1 (ALS) and frontotemporal dementia (Frontotemporal dementia). Like several other ALS-associated Protein... | yes |
Does TGF-beta play a role in cardiac regeneration after myocardial infarction? | converted_29 | Does Recombinant Transforming Growth Factor-Beta play a role in cardiac regeneration after myocardial infarction? | We then performed a chemical screen and identified several small molecules that increase or reduce Myocytes, Cardiac proliferation during heart development. These compounds act via Subfamily Erinaceinae, Insulin-Like Growth Factor I or Transforming growth factor β signaling pathways. Here, we report that the balance b... | yes |
Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | converted_30 | Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | DITPA normalized the elevated serum T(3) and Thyrotropin:-:Pt:Ser/Plas:- when the dose reached 1 mg/kg · d and T(4) and rT(3) increased to the lower normal range. The identification of 3,5-diiodothyropropionic acid (DITPA) that binds to both α- and β-type threonine-tRNA ligase activity with relatively low affinity was ... | yes |
Is MammaPrint cleared by the United States Food and Drug Administration? | converted_31 | Is MammaPrint cleared by the United States Food and Drug Administration? | Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX Breast Cancer Assay Breast Cancer Assay recurrence score assay panel.[SEP]Relations: salivary gland type cancer of the breast has relations: disease_disease wit... | yes |
Is amantadine effective for treatment of disorders conciousness? | converted_32 | Is amantadine effective for treatment of disorders conciousness? | We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from Apraxia, oculomotor, Cogan type. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, lea... | yes |
Is GAGA associated with nucleosome-free regions (NFR)? | converted_33 | Is Gaga associated with nucleosome location-free regions (NFR)? | One of the three nuclease hypersensitive sites in the Fab-7 boundary, EEF1A2 wt Allele, contains multiple consensus-binding sequences for the Gaga factor, a Protein Info known to be involved in the formation and/or maintenance of nucleosome location location-free regions of chromatin location location. The SPHEROCYTOSI... | yes |
Is amiodarone a class I anti-arrhythmic drug? | converted_34 | Is amiodarone a Canadian Cardiovascular Society Grading Scale Class I Antiarrhythmic [EPC] drug? | Common Canadian Cardiovascular Society Grading Scale Class I agents are excluded due to the inherent abnormal cardiac structure and function in the setting of Shock, Cardiogenic. Class III drug options include dofetilide and amiodarone. amiodarone has been used as an Antiarrhythmic [EPC] drug since the 1970s and has an... | no |
Has the protein TIEG1 been associated with apoptosis? | converted_35 | Has the protein TIEG1 been associated with apoptosis? | Recombinant Transforming Growth Factor-Beta) inducible early gene 1 (TIEG1) is known to induce apoptosis in Recombinant Transforming Growth Factor-Beta sensitive Malignant neoplasm of pancreas Cells, yet its effect on Recombinant Transforming Growth Factor-Beta resistant cancer Cells remains unclear overexpression of T... | yes |
Is PTEN involved in follicular thyroid carcinoma? | converted_36 | Is PTEN protein, human involved in Follicular THYROID DIAGNOSTIC RADIOPHARMACEUTICALS carcinoma? | Two of the 259 patients (0.8%), with both Follicular THYROID DIAGNOSTIC RADIOPHARMACEUTICALS carcinoma and Large head (disorder), were found to carry a germline mutation in the PTEN protein, human protein, human gene. The PTEN protein, human protein, human mutation frequency in unselected cases of Follicular THYROID DI... | yes |
Does strenuous physical activity affect thyroid hormone metabolism? | converted_37 | Does strenuous physical activity affect Thyroid Hormones metabolism? | The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T(3) syndrome liothyron... | yes |
Is the gene MAOA epigenetically modified by methylation? | converted_38 | Is the gene MAOA protein, human epigenetically modified by methylation? | Evidence that the methylation state of the MAOA protein, human protein, human gene (MAOA protein, human protein, human) gene predicts brain activity of Monoamine Oxidase A Enzyme [APC] in healthy men. We found significant interindividual differences in methylation status and methylation patterns of the core MAOA protei... | yes |
Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | converted_39 | Is Glycine-tRNA Ligase Genes involved in the development of Charcot-Marie-Tooth Disease? | Charcot-Marie-Tooth Disease type 2D (Charcot-Marie-Tooth Disease, Type 2D) is an autosomal-dominant axonal peripheral neuropathy characterized by impaired motor and sensory function in the distal extremities. Mutations in the Glycine-tRNA Ligase (GARS) Genes cause Charcot-Marie-Tooth Disease, Type 2D Dominant Gene Muta... | yes |
Is there any software for automated analysis of FISH images? | converted_40 | Is there any software for automated analysis of FISH images? | he study demonstrated the feasibility of automated FISH signal analysis that applying a cyclophosphamide/dacarbazine/doxorubicin protocol scheme to the automated generated 2-D projection images. A color imaging technique, multiplex fluorescent in situ hybridization (M-FISH), has been developed to ease the analysis of t... | yes |
Is there an increased risk for cancer in Dyskeratosis Congenita? | converted_41 | Is there an increased risk for cancer in Dyskeratosis Congenita? | People with DC are at increased risk for progressive Bone marrow hypocellularity (Bcl-2-Modifying Factor), MYELODYSPLASTIC SYNDROME (Miller Dieker syndrome) or acute myelogenous leukemia (Leukemia, Myelocytic, Acute), Solid Neoplasm (usually Anal Anal squamous cell carcinoma of the head/neck or anogenital cancer), and ... | yes |
Does MicroRNA-21 (miR-21) contribute to cardiovascular disease? | converted_42 | Does MicroRNA-21 (MIR21 gene) contribute to Cardiovascular Diseases? | The synergistic effect of MIR21 gene and miR-1 were functionally validated for their significant influences on Myocardial apoptosis, Cardiac - anatomy qualifier hypertrophy and Fibrosis. Taken together, we found a novel reciprocal loop between MIR21 gene and TGFβRIII in Cardiac - anatomy qualifier Fibrosis caused by My... | yes |
Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | converted_43 | Are there any statistical methods for normalizing and identifying differential regions in histone modification Chromatin Immunoprecipitation Sequencing data? | ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification Chromatin Immunoprecipitation Sequencing libraries. In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize Chromatin Immunoprecipitation Sequencing data, and to find differential r... | yes |
Is CD84 genetically associated with arthritis? | converted_44 | Is CD84 gene genetically associated with arthritis? | The Single Nucleotide Polymorphism is predicted to disrupt transcription factor binding site motifs in the 3' Untranslated Regions of an immune-related gene, CD84 gene gene, and the Alleles associated with better response to etanercept was associated with higher CD84 gene gene gene expression in Peripheral blood mononu... | yes |
Are there any specific antidotes for rivaroxaban? | converted_45 | Are there any specific antidotes for rivaroxaban? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of Cerebral Hemorrhage (HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO). However, two facts make this situation complicated: First, the risk of Hematoma expansion is unknown for NOACs. Second, there is no specific ... | no |
Is cytisine superior to nicotine replacement therapy for smoking cessation? | converted_46 | Is cytisine superior to nicotine replacement therapy for smoking cessation? | The effectiveness of cytisine for continuous abstinence was superior to that of nicotine-replacement therapy at 1 week, 2 months, and 6 months. In a prespecified subgroup analysis of the primary outcome, cytisine was superior to nicotine-replacement therapy among women and noninferior among men. CONCLUSIONS: When combi... | yes |
Is the abnormal dosage of ultraconserved elements disfavored in cancer cells? | converted_47 | Is the abnormal dosage of ultraconserved elements disfavored in Primary malignant neoplasm cells? | Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not Primary malignant neoplasm cells. We begin by showing that depletion for UCEs characterizes the most recent large-scale Homo sapiens CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis ... | no |
Does thyroid hormone regulate calcium transient in the myocardium? | converted_48 | Does Thyroid Hormones regulate CALCIUM SUPPLEMENTS transient in the myocardium? | 3-iodothyronamine (T(1)AM) is a novel endogenous relative of Thyroid Hormones, able to interact with trace amine-associated receptors, a class of Plasma membrane G protein-coupled receptors, and to produce a negative inotropic and chronotropic effect In adult rat cardiomyocytes acute exposure to 20 microM T(1)AM decrea... | yes |
Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | converted_49 | Are Proteasome inhibitors, antineoplastic agent good candidates for treatment of leukemia and solid Neoplasms? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an RUNX1 gene model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target We further found that ATO targets Minera... | yes |
Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | converted_50 | Is there any link between WDHD1 gene and CTF18 during sister chromatid cohesion? | Our results suggest that ATAD5 wt Allele, Ctf4, and CHTF18 gene may coordinate the relative movement of the replication fork with respect to the cohesins ring These data defined two cohesion pathways, one containing CSM3, TOF1, WDHD1 gene, and DDX11 gene, and the second containing MRC1 gene gene, CTF18, CHTF8 gene, and... | yes |
Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | converted_51 | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | This study reports the consequences of levothyroxine treatment over a prolonged period of time in 2 of the first patients with a heterozygous Mutation Abnormality in TRα1. Here we show that the dysregulation of the pituitary-thyroid axis was worsened by the lack of Tricuspid Valve Insufficiency alpha1 in Tricuspid Valv... | yes |
Does administration of triiodothyronine improve outcome following coronary artery bypass grafting? | converted_52 | Does administration of liothyronine improve outcome following coronary artery bypass grafting? | Serum SLC25A5 gene concentrations were significantly higher with fewer patients having SLC25A5 gene concentrations below the normal range in the SLC25A5 gene group than the placebo group throughout the postoperative period. Hemodynamic variables, postoperative inotrope requirement, and outcome variables showed no diffe... | no |
Is long QT syndrome a cause for sudden cardiac death in athletes? | converted_53 | Is Long QT Syndrome a cause for sudden cardiac Cessation of life in athletes? | A diversity of Cardiovascular Diseases including Hypertrophic obstructive cardiomyopathy, congenital coronary anomalies, ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA 1, Cardiomyopathy, Dilated, Aortic Rupture due to Marfan syndrome, Myocarditis, Valvular disease and electrical disorders (Wolff-Parkinson-White Syndrome, L... | yes |
Is protein M3/6 a dual specificity phosphatase? | converted_54 | Is protein M3/6 a dual specificity Phosphoric Monoester Hydrolases? | Involvement of the Dual-Specificity Phosphatases M3/6 in c-Jun N-terminal kinase inactivation following Cerebral Infarction in the Rattus norvegicus hippocampus. The results revealed upregulation of Dual-Specificity Phosphatases M3/6 (DUSP8 gene gene) activity at 4 h of reperfusion in Rattus norvegicus hippocampi. Thi... | yes |
Are there focused databases from which you can retrieve gene expression data on renal disease? | converted_55 | Are there focused databases from which you can retrieve gene expression data on renal disease? | Proteomics database in Chronic Kidney Diseases Naturally occurring Homo sapiens urinary peptides for use in diagnosis of Chronic Kidney Diseases[SEP]Relations: Chronic kidney disease has relations: disease_phenotype_positive with glycogen storage disease, disease_phenotype_positive with glycogen storage disease, diseas... | yes |
Are there any DNMT3 proteins present in plants? | converted_56 | Are there any DNMT3 proteins present in plants? | De novo DNA methylation in Arabidopsis sp. sp. thaliana <Plant allergen> is catalyzed by the methyltransferase DRM2, a Homologous Gene of the Mammals de novo methyltransferase DNMT3. Here we describe DNA Modification Methylases Genes from both Arabidopsis sp. sp. and maize that show a high level of Sequence - Parameter... | yes |
Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | converted_57 | Has ergocalciferol has been shown to reduce incidence of falls in older people in clinical trials? | However, apart from the beneficial effects of 800 IU/d of cholecalciferol for reduction of falls in the elderly, causality remains yet unproven in randomized controlled trials (RCTs). The rate of falls and the number of fallers was significantly reduced in two studies evaluating the effect of medication on preventing ... | yes |
Has depression been shown to be a predictor of frailty? | converted_58 | Has Cancer patients and suicide and depression been shown to be a predictor of frailty? | significant role of frailty as a predictor of Cancer patients and suicide and Cancer patients and suicide and depression in a relatively younger old Chinese population significant relationships between frailty and Depressive Symptoms and mortality at 1 year These findings suggest that Malnutrition is a major predictor ... | yes |
Is there any association between Jarid2 and miR-155 in Th17 cells? | converted_59 | Is there any association between JARID2 gene and miR-155 in Th17 Cells? | JARID2 gene links MicroRNA and Chromatin in Th17 Cells. In this issue of Immunity, Escobar et al. (2014) bring MicroRNAs and Chromatin together by showing how activation-induced miR-155 targets the Chromatin protein JARID2 gene to regulate proinflammatory cytokine production in T helper 17 Cells. miR-155 activates cyto... | yes |
Is it safe to take isotretinoin during pregnancy? | converted_60 | Is it safe to take isotretinoin during pregnancy? | isotretinoin is a remarkably effective Pharmacologic Substance for severe, recalcitrant Acne Vulgaris vulgaris. a number of important adverse effects were reported even the most recent pregnancy prevention program (iPledge) is no more successful than prior programs; there will likely always be a small number of female ... | no |
Can DNA intercalators function as topoisomerase inhibitors? | converted_61 | Can DNA Intercalating Agents function as Topoisomerase II inhibitors? | The aporphine Alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar Molecule lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a Topoisomerase II II (EC 5.99.1.3) PPP1R1A gene and also was active in a DNA unwind... | yes |
Do orphan and gene related CpG islands follow power-law-like distributions? | converted_62 | Do orphan and Genes related CpG islands follow power-law-like distributions? | Orphan and Genes related CpG Islands follow power-law-like distributions in several genomes: evidence of function-related and taxonomy-related modes of distribution. Here, an investigation of their distributional characteristics in a variety of genomes is undertaken for both whole CGI populations as well as for CGI sub... | yes |
Can valproic acid act as an activator of AMPK? | converted_63 | Can valproic acid act as an activator of AMP-Activated Protein Kinases? | Here we demonstrate that valproic acid is a novel activator of AMP-activated protein kinase (AMP-Activated Protein Kinases), a key regulator of cellular metabolism, using primary mouse and human hepatocytes. These studies are the first to establish valproic acid and its Metabolite as in vitro activators of AMP-Activate... | yes |
Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | converted_64 | Is the Drosophila <basidiomycetes> Translational Control Element (Tethered Capsule Endomicroscopy) involved in spermatogenesis? | Gene regulation in Drosophila <basidiomycetes> <basidiomycetes> spermatogenesis: analysis of protein binding at the translational control element Tethered Capsule Endomicroscopy. We have previously identified a 12 nucleotide long sequence element, the Tethered Capsule Endomicroscopy, that was demonstrated to be necessa... | yes |
Is low T3 syndrome a prognostic marker in patients with renal insufficiency? | converted_65 | Is low SLC25A5 gene syndrome a prognostic marker in patients with renal insufficiency? | Low SLC25A5 gene was particularly common (44.3 %), and clearly associated with increased 6- and 12-month mortality and decreased overall survival (log rank test, P=0.007). Increased rT3 may be more common in Kidney Failure, Chronic patients than previously described, and together with decreased SLC25A5 gene it may ser... | yes |
Does burning mouth syndrome preferentially affect post-mepopausal women? | converted_66 | Does burning mouth syndrome preferentially affect post-mepopausal women? | It is observed principally in middle-aged patients and postmenopausal women and may be accompanied by Xerostomia and altered taste. It occurs more commonly in middle-aged and elderly women and often affects the tongue tip and lateral borders, Lip structure, and hard and soft palate. BMS is a Chronic disease that frequ... | yes |
Can life style changes reduce oxidative stress | converted_67 | Can life style changes reduce oxidative stress | The Chronic Fatigue Syndrome group had an unfavorable lipid profile and signs of oxidative stress induced damage to Lipids and Proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for Arteriosclerosis. Antioxidant treatment and life style ... | yes |
Is oxidative stress affected by FOXO expression? | converted_68 | Is oxidative stress affected by FOXO expression? | Forkhead-box class O (FOXO Family) TRANSCRIPTION FACTOR regulate mechanisms of cellular aging, including protein quality control, autophagy and defenses against oxidative stress. Statin-mediated upregulation of KL wt Allele expression and differential regulation of FOXO Family expression promote resistance to CsA-induc... | yes |
Is the Dictyostelium discoideum proteome known? | converted_69 | Is the Dictyostelium discoideum proteome known? | The Negative Proteome Database (neodymium pyrocatechin disulfonate) is populated with pair-wise protein Sequence - ParameterizedDataType comparisons between each of the following proteomes: Homo sapiens, House mice, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae or Saccharomyces cerevisiae ce... | yes |
Is single-cell analysis (SCA) possible in proteomics? | converted_70 | Is single-cell analysis (Structure of superior cerebellar artery) possible in proteomics? | Toward Single Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry. he advent of proteomics and genomics at a single-cell level has set the basis for an outstanding improvement in analytical technology and data acquisition. The new-generation technology of single-cell analysis ... | no |
Is shotgun lipidomics the direct infusion of a lipid sample into a mass spectrometer? | converted_71 | Is shotgun lipidomics the direct infusion of a lipid sample into a mass spectrometer? | In direct infusion/injection (or shotgun) lipidomics An efficient shotgun lipidomics strategy was established and optimized for fast phospholipid profiling of Viscera from three fish species: Lateolabrax japonicas, Grass Carp (fish), and Carassius carassius x Carassius carassius x Carassius auratus auratus auratus. Thi... | yes |
Is apixaban effective for treatment of acute venous thromboembolism? | converted_72 | Is apixaban effective for treatment of acute venous thromboembolism? | Apixaban is a direct inhibitor of Factor Xa, and is a potential alternative for the treatment of acute venous thromboembolism. These results suggest a lack of clear superiority of apixaban relative to enoxaparin. Apixaban is an Oral Route of Drug administration alternative with similar efficacy and safety to existing ... | yes |
Is the tricarboxylic acid (TCA) cycle affected in inflammation? | converted_73 | Is the Tricarboxylic Acids (Tricyclic Antidepressant [EPC]) cycle affected in Inflammation? | In this study, the levels of Antifibrinolytic Antifibrinolytic amino acids and trichloroacetic acid (Tricyclic Antidepressant [EPC]) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (Ulcerative Colitis) were profiled by gas chromatography/mass spectrometry (GC/MS), with the ai... | yes |
Are reduced-nicotine cigarettes effective for smoking cessation? | converted_74 | Are reduced-nicotine cigarettes effective for Location characteristic ID - Smoking cessation? | CONCLUSIONS: In this 6-week study, reduced-nicotine cigarettes versus standard-nicotine cigarettes reduced nicotine exposure and dependence and the number of cigarettes smoked. RESULTS: Significant reductions in nicotine intake were observed between usual brand Location characteristic ID - Smoking (∼1.2 mg nicotine) a... | yes |
Is the Wnt protein modified by notum? | converted_75 | Is the Wnt protein modified by notum? | NOTUM gene deacylates Wnt Proteins to suppress signalling activity. Kinetic and mass spectrometric analyses of NR4A2 protein, human show that NOTUM gene is a carboxylesterase that removes an essential palmitoleate moiety from Wnt Proteins and thus constitutes the first known extracellular protein deacylase. the Wnt PPP... | yes |
Is ospemifene effective for treatment of dyspareunia? | converted_76 | Is ospemifene effective for treatment of Have Dyspareunia question? | Ospemifene, a novel selective Estrogen Receptor Modulators, has been developed for the treatment of Vulvovaginal atrophy and Have Dyspareunia question in postmenopausal women. For the comparison of short-term ospemifene with placebo, parabasal cells (the standardized mean difference [Spondylometaphyseal dysplasia] = -... | yes |
Is pregabalin effective for treatment of patients with restless leg syndrome? | converted_77 | Is pregabalin effective for treatment of patients with restless leg syndrome? | CONCLUSIONS: This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole. Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole. CONCLUSIONS: pregabalin provided signif... | yes |
Can zinc finger nucleases be used to combat disease? | converted_78 | Can Zinc Fingers nucleases be used to combat disease? | Genetic engineering has emerged as a powerful mechanism for understanding biological systems and a potential approach for redressing Congenital Disorders. This is of particular importance, given the momentum currently behind ZFNs in moving into phase I clinical trials. This study provides a historical account of the or... | yes |
Is RET the major gene involved in Hirschsprung disease? | converted_79 | Is ret unit of radiation dose the major Genes involved in HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1? | The ret unit of radiation dose Proto-Oncogenes is the major Genes associated to HSCR with differential contributions of its rare and common, coding and noncoding Gene Mutation to the multifactorial nature of this pathology The ret unit of radiation dose Proto-Oncogenes is the major Genes for HSCR with differential cont... | yes |
is intense physical activity associated with longevity ? | converted_80 | is intense physical activity associated with longevity ? | We found a very significant increase in average longevity (17%) of the cyclists when compared with the general population. The age at which 50% of the general population died was 73.5 vs. 81.5 years in Tour de France participants. Our major finding is that repeated very intense exercise prolongs life span in well train... | yes |
Are cyclophilins proteins that bind to prolines? | converted_81 | Are Cyclophilins Proteins that bind to prolines? | Cyclophilins are ubiquitously expressed Proteins that bind to prolines and can catalyse CISH protein, human/trans isomerization of proline residues. a characteristic of the cyclophilin family of Proteins that bind prolines and often act as CISH protein, human-trans peptidyl-prolyl isomerases. The Cyclophilins are wide... | yes |
Can a given genotype exhibit opposite fitness effects (beneficial and detrimental) within the same environment? | converted_82 | Can a given genotype exhibit opposite fitness effects (beneficial and detrimental) within the same environment? | Mutations beneficial in one environment may cause costs in different environments, resulting in antagonistic pleiotropy. Here, we describe a novel form of antagonistic pleiotropy that operates even within the same environment, where benefits and deleterious effects exhibit themselves at different growth rates. The hfq ... | yes |
Has the protein SETMAR (Metnase) a transposase domain? | converted_83 | Has the Protein Info SETMAR gene (Metnase) a Transposase Superkingdom (taxonomic category)? | Metnase (SETMAR gene gene) is a Parameterized Data Type - Set-Transposase fusion Protein Info that promotes nonhomologous end joining (Non-Homologous DNA End-Joining) repair in Homo sapiens. The Transposase Superkingdom (taxonomic category) Protein Info Metnase/SETMAR gene gene suppresses chromosomal translocations. M... | yes |
Is nucleosome eviction ATP-dependent? | converted_84 | Is nucleosome location eviction ATP-dependent? | ATP-dependent chromatin location location remodeling and nucleosome location location-depleted 'barriers' co-operate to determine the kinetics of nucleosome location location organization ATP-dependent nucleosome location location-remodeling factors endow chromatin location location with structural flexibility by promo... | yes |
Is TREM2 associated with Alzheimer's disease in humans? | converted_85 | Is TREM2 protein, human associated with ALZHEIMER DISEASE, FAMILIAL, 1 in humans? | Genetic deficits and loss of function for the triggering receptor expressed in Myeloid Cells (TREM2 protein, human protein, human; encoded at chr6p21.1), a fully spanning the plasma membrane spanning stimulatory receptor of the immunoglobulin/lectin-like Genes superfamily, have been associated with deficiencies in phag... | yes |
Have mutations in the Polycomb group been found in human diseases? | converted_86 | Have mutations in the Polycomb group been found in human diseases? | We identify a novel Mutation Abnormality in PHC1 Genes Genes, a human orthologue of the Drosophila polyhomeotic member of polycomb group (Polycomb-Group Proteins), which significantly decreases PHC1 Genes Genes protein expression, increases GMNN protein, human protein level and markedly abolishes the capacity to ubiqui... | yes |
Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | converted_87 | Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (Necrotic changes (finding) and apoptosis), Myocyte hypertrophy, angiogenesis, cardiac Fibrosis, and Myocardial dysfunction. I In addition, MIR21 gene, -24, -133, -210, -494, and -499 appear to protect Muscle Cells against I/R-indu... | yes |
Can sorafenib activate AMPK? | converted_88 | Can sorafenib activate AMP-Activated Protein Kinases? | Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMP-Activated Protein Kinases), in a manner that involves either upstream LKB1 or CAMKK2 gene gene. Persistent activation of AMP-Activated Protein Kinases by sorafenib finally led to the impairment of glucose metabolism both in MCF-7 and SKBR... | yes |
Is Vortioxetine effective for treatment of depression? | converted_89 | Is Vortioxetine effective for treatment of Cancer patients and suicide and depression? | Vortioxetine is an orally administered small Molecule developed by Lundbeck A/S for the once-daily treatment of major depressive disorder (Major Depressive Disorder) and generalized anxiety disorder (Generalized Anxiety Disorder). Vortioxetine received its first global approval for Major Depressive Disorder in the USA ... | yes |
Is exome sequencing efficient for the detection of germline mutations? | converted_90 | Is exome sequencing efficient for the detection of germline Gene Mutation? | Whole exome sequencing is an efficient and sensitive method for detection of germline Gene Mutation in patients with phaeochromcytomas and PARAGANGLIOMAS 5 Whole exome sequencing is sensitive, rapid and efficient for detection of PCC/PGL germline Gene Mutation. These results from deep sequencing demonstrate a higher mu... | yes |
Is it feasible to determine the complete proteome of yeast? | converted_91 | Is it feasible to determine the complete proteome of Saccharomyces cerevisiae? | or model organisms like Saccharomyces cerevisiae or Saccharomyces cerevisiae cerevisiae, we can now quantify complete proteomes in just a few hours. A complete mass-spectrometric map of the Saccharomyces cerevisiae or Saccharomyces cerevisiae cerevisiae proteome applied to quantitative trait analysis. So far, attempts ... | yes |
Are circRNAs associated with diseases and traits? | converted_92 | Are circRNAs associated with diseases and traits? | Circ2Traits: a comprehensive database for circular RNA potentially associated with Disease and traits. Circular RNA play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the MicroRNAs. Their interaction with Disease associated MicroRNAs indicates that circular RNA ... | yes |
Could the Menzerath-Altmann law be proved mathematically trivial in genomes? | converted_93 | Could the Menzerath-Altmann law be proved mathematically trivial in Genome? | Here we review the statistical foundations of that test and consider three non-parametric tests based upon different correlation metrics and one parametric test to evaluate if Upper case Roman letter Upper case Roman letter Z ∼ 1/X in Genome. The most powerful test is a new non-parametric one based upon the correlation... | yes |
Are there studies representing the involvement of Notch mutations in neurodegenerative diseases such as Down syndrome, Pick's and Prion's disease, and cadasil syndrome? | converted_94 | Are there studies representing the involvement of Notch Gene Mutation in neurodegenerative diseases such as Down Syndrome, Pick's and Prion's disease, and cadasil syndrome? | he Notch signaling pathway plays a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis, and is a highly conserved signaling pathway that regulates normal development in a context- and dose-dependent manner. Dysregulation of Notch signaling has been suggested to be key even... | yes |
Are there any functional differences between Mfd and its human Cocaine syndrome protein B (CSB) homolog? | converted_95 | Are there any functional differences between Mfd and its human Cocaine syndrome protein B (Cockayne Syndrome, Type II) homolog? | In Homo sapiens, the transcription-coupled nucleotide-excision repair coupling factor, Cockayne Syndrome, Type II, plays a critical role in restoring transcription following both UV-induced and oxidative DNA damage. It also contributes indirectly to the global repair of some forms of oxidative DNA damage. The Escherich... | yes |
Is the yeast Μac1 transcription factor induced upon copper deficiency? | converted_96 | Is the Saccharomyces cerevisiae Μac1 transcription factor induced upon Hypocupremia? | Low-affinity copper transporter SLC31A2 gene is regulated by copper-sensing transcription factor Mac1p in Saccharomyces cerevisiae or Saccharomyces cerevisiae cerevisiae or Saccharomyces cerevisiae or Saccharomyces cerevisiae cerevisiae cerevisiae. The copper-depletion induced SLC31A2 gene transcription can be abrogate... | yes |
Have thyronamines effects on fat tissue? | converted_97 | Have thyronamines effects on fat tissue? | In conclusion, trace amines and thyronamines are negative inotropic agents. Their in vivo administration induces effects opposite to those induced by Thyroid Hormones, including lowering of body temperature.[SEP]Relations: response to Thyroid Hormones has relations: bioprocess_protein with GBA, bioprocess_protein with ... | no |
Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | converted_98 | Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its combination with the curren... | yes |
Is there an association between TERT promoter mutation and survival of glioblastoma patients? | converted_99 | Is there an association between TERT wt Allele promoter mutation and survival of glioblastoma patients? | Glioblastoma Multiforme Multiforme patients with TERT wt Allele wt Allele mutations showed a shorter survival than those without TERT wt Allele wt Allele mutations in univariate analysis (median, 9.3 vs. 10.5 months; P = 0.015) and multivariate analysis after adjusting for age and gender (plant-type hypersensitive resp... | yes |
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