id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 28.4k | label stringclasses 2
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converted_733 | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enter... | yes |
converted_3936 | Is cabergoline used for treatment of the Nelson's syndrome ? | Due to a rapid regrowth of the tumour, the patient did not receive gamma-knife therapy and was treated with cabergoline and somatostatin analogue for some time. , Identification of D(2) receptors in corticotroph tumors led to clinical trials of cabergoline therapy in limited cases of Nelson's syndrome, ectopic ACTH-sec... | yes |
converted_2854 | Is pacritinib effective for treatment of myelofibrosis? | Pacritinib and its use in the treatment of patients with myelofibrosis who have thrombocytopenia., Pacritinib, a dual JAK2 and FLT3 inhibitor which also inhibits IRAK1, has demonstrated the ability to favorably impact MF-associated splenomegaly and symptom burden, while having limited myelosuppression with manageable g... | yes |
converted_1937 | Does NADPH oxidase 5 require any subunit for function? | Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain., While Nox1-4 require regulatory subunits, including p22phox, Nox5 activity does not depend on any subunits. , Thus, Nox5 forms a catalytically active oligomer in the membrane that is mediated by its dehydrogenase domain. , Coe... | no |
converted_2284 | Has IVIG been tested in clinical trials for the treatment of Alzheimer's disease? | Clinical trials of intravenous immunoglobulin for Alzheimer's disease., Preclinical and clinical studies have shown that IVIG has anti-amyloid and immune modulatory properties relevant to treating neurodegenerative disorders. In early stage AD clinical trials, IVIG was found to reduce cognitive decline and increase bra... | yes |
converted_2874 | Are phagosomal proteins ubiquitinated? | Phagosomal proteins are ubiquitylated, and ubiquitylation was found to be required for formation of acidic multivesicular structures., membranes of the bacterial phagosome are enriched with ubiquitinated proteins in a way that requires its Dot/Icm type IV secretion system, suggesting the involvement of effectors in the... | yes |
converted_4587 | Does atemoya juice inhibit the CYP1A2 enzyme? | Atemoya juice significantly inhibited CYP1A2 activity in human liver microsomes, but not the activities of CYP2C9 and CYP3A., This suggests that the intake of an excess amount of atemoya juice is necessary to cause a change in the pharmacokinetics of phenacetin when the IC50 values for CYP1A2 inhibition by atemoya and ... | yes |
converted_1071 | Are there any specific antidotes for dabigatran? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. ,... | no |
converted_1900 | Has "RNA interference" been awarded Nobel prize? | Since the first unequivocal description of RNA interference (RNAi) in 1998, it has remained one of the hottest topics under investigation, culminating in the award of a Nobel Prize to its discoverers in 2006., RNA interference (RNAi) is considered one of the most powerful genomic tools which allows the study of drug di... | yes |
converted_328 | Can sorafenib activate AMPK? | Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. , Persistent activation of AMPK by sorafenib finally led to the impairment of glucose metabolism both in MCF-7 and SKBR3 cells as well as in the highly glycolytic MDA-MB-231 cell... | yes |
converted_2851 | Is TIAM1 favoring tumor progression in colorectal cancer (CRC)? | Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling. We demonstrate that TIAM1 shuttles between the cytoplasm and nucleus antagonizing TAZ/YAP by distinct mechanisms in the two compartments. In the cytoplasm, TIAM1 localizes to the destruction c... | no |
converted_1447 | Has silicon been used in treatment of incontinence ? | an artificial anal sphincter. Worldwide, there are two established devices on the market: the artificial bowel sphincter® (ABS) from A. M. S. (Minnetonka, MN, USA) and the soft anal band® from A. M. I. (Feldkirch, Austria). How to implant the artificial anal sphincter? Both devices consist of a silicon cuff which can b... | yes |
converted_166 | Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries., In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize ChIP-seq data, and to find differential regions in the genome, given two libraries of histone modificati... | yes |
converted_847 | Is transcription-associated mutagenesis (TAM) related to gene expression levels? | These mutations were frequent in plasmid-borne lacS expressed at a high level but not in single-copy lacS in the chromosome or at lower levels of expression in a plasmid., The results suggest that important DNA repair or replication fidelity functions are impaired or overwhelmed in pJlacS, with results analogous to tho... | yes |
converted_2428 | Is autosomal dominant inheritanced form of Osteogenesis imperfecta caused by mutations in the genes associated with collagen production? | steogenesis imperfecta (OI) is a heterogeneous bone disorder characterized by recurrent fractures. Although most cases of OI have heterozygous mutations inCOL1A1orCOL1A2and show autosomal dominant inheritance,, Osteogenesis imperfecta (OI) is a group of hereditary disorders characterized by decreased bone mass and incr... | yes |
converted_573 | Are there telemedicine applications for chronic pain management? | An integrated cognitive-behavioral and physical therapy group protocol has been developed and then implemented at remote sites using videoconferencing technology to provide pain management for veterans. , Tele-pain management: use of videoconferencing technology in the delivery of an integrated cognitive-behavioral and... | yes |
converted_2630 | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis., Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expr... | yes |
converted_2106 | Does GATA-1 regulate ribosomal protein genes? | Mutations in exon 2 interfere with the synthesis of the full-length isoform of GATA-1 and lead to the production of a shortened isoform, GATA-1s. These mutations have been found in patients with Diamond-Blackfan anemia (DBA), a congenital erythroid aplasia typically caused by mutations in genes encoding ribosomal prote... | yes |
converted_49 | Are ultraconserved elements often transcribed? | Starting from a genome-wide expression profiling, we demonstrate for the first time a functional link between oxygen deprivation and the modulation of long noncoding transcripts from ultraconserved regions, termed transcribed-ultraconserved regions (T-UCRs), Our data gives a first glimpse of a novel functional hypoxic ... | yes |
converted_1145 | Could RG7112 be used as cancer therapy? | RG7112 is a potent and selective member of the nutlin family of MDM2 antagonists currently in phase I clinical studies., Our findings offer a preclinical proof-of-concept that RG7112 is effective in treatment of solid tumors expressing wild-type p53., On the other hand, JNJ-26854165, a novel tryptamine derivative and R... | yes |
converted_1281 | Is TNNI3K a cardiac-specific protein? | cardiomyocyte-specific kinase TNNI3K , We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase,, TNNI3K, a cardiac-specific kinase, , The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy, Human cardiac t... | yes |
converted_3234 | Anaplasma phagocytophilum is an obligate gram-negative, intracellular bacterium, yes or no | The genus Anaplasma belonging to the Anaplasmataceae family (order Rickettsiales) comprises obligate intracellular Gram-negative bacteria of veterinary and public health importance. Six species and five types of strains genetically related are currently assigned to the genus Anaplasma including Anaplasma marginale, A. ... | yes |
converted_4629 | Is covid-19 induced anosmia caused by disruption of nuclear architecture? | Disruption of nuclear architecture as a cause of COVID-19 induced anosmia., Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory receptors (ORs) as well as key components... | yes |
converted_1563 | Are cyclophilins ubiquitously expressed? | Cyclophilin from Leishmania donovani (LdCyp) is a ubiquitous peptidyl-prolyl cis-trans isomerase, Cyclophilins (CYPs) and FK506-binding proteins (FKBPs) are ubiquitous proteins belonging to the peptidyl-prolyl cis/trans isomerase (PPIase) family., However, their wide distribution and ubiquitous nature signifies their ... | yes |
converted_3479 | Is modified vaccinia Ankara effective for smallpox? | BACKGROUND: Modified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. , The three MVA lots induced equivalent antibody titers two weeks after the second vaccination, with seroconversion rates of 99·8% (PRNT) and 99·7% (ELISA). , INTRODUCTION: To guide the ... | yes |
converted_2274 | Is autophagy modulated in a circadian fashion? | TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in behavior and plasticity of L2 interneurons in the brain of Drosophila melanogaster., Our results indicate that the TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in the behavior and plast... | yes |
converted_4263 | Is FTY720 FDA approved? | FTY720 (Fingolimod) is a known sphingosine-1-phosphate (S1P) receptor agonist that exerts strong anti-inflammatory effects and was approved as the first oral drug for the treatment of multiple sclerosis by the US Food and Drug Administration (FDA) in 2010. [SEP]Relations: Fingolimod has relations: drug_drug with WIN 55... | yes |
converted_3707 | Has MLE4901 been tested in phase III clinical trials? | METHODS
This phase 2, randomised, double-blind, placebo-controlled, single-centre, crossover trial assessed the effectiveness of an oral neurokinin 3 receptor antagonist (MLE4901) on menopausal hot flushes., Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double... | no |
converted_388 | Is there an association between borna virus and brain tumor? | Borna disease virus (BDV), a nonsegmented, negative-strand RNA virus, infects a wide variety of mammalian species and readily establishes a long-lasting, persistent infection in brain cells. , To investigate the biological characteristics of field isolates of Borna disease virus (BDV), as well as to understand BDV infe... | no |
converted_3174 | Was stelara developed by Amgen? | NICE does not specifically recommend switching from one biologic to another, and only ustekinumab (UST; STELARA®, Janssen Pharmaceuticals, Inc., Horsham, PA, USA) is recommended after anti-tumour necrosis factor failure.[SEP]Relations: Ustekinumab has relations: drug_drug with AMG 108, drug_drug with AMG 108, drug_drug... | no |
converted_2790 | Is the PINES framework being used for the prediction of coding variants? | PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants., Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the functional impact of noncoding variants by integrating epigenetic annotations in a phenotype-dependent... | no |
converted_3897 | Can Freund's complete adjuvant induce arthritis? | complete Freund's adjuvant (CFA) induced RA, The RA model was established using Freund's complete adjuvant, , Rheumatoid arthritis (RA) was induced by Freund's Complete Adjuvant (FCA; 1 mg/0.1 ml paraffin oil), injected subcutaneously on days 0, 30 and 40, The rats were made arthritic using a subcutaneous injection wi... | yes |
converted_4701 | Is ASF1 phopshorylated by the Tousled-like kinases? | Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-like kinases (TLKs). , The Tousled-like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaperone, The Tousled-like kinases (TLKs) are involved in chromatin assembly, DNA repair, and transcription. T... | yes |
converted_4370 | Is hemoglobin antimicrobial? | the α137-141 peptide, a natural antimicrobial peptide, can be obtained after hydrolysis of hemoglobin, the main constituent of blood red part, Beyond its physiological activity, hemoglobins are able to inhibit the growth of several microorganisms., A novel AMP, T. granosa hemoglobin-derived peptide (TGH1), was identifi... | yes |
converted_831 | Have 5q35 microdeletions been implicated in Sotos syndrome development? | Loss-of-function mutations of NSD1 and 5q35 microdeletions encompassing NSD1 are a major cause of Sotos syndrome (Sos), which is characterized by overgrowth, macrocephaly, characteristic facies, and variable intellectual disability (ID), We observed a novel 3.5 Mb 5q subtelomeric deletion in a 3-year-old girl with deve... | yes |
converted_1691 | Is STAT3 transcription factor regulated by mTORC1? | Mechanistically, mTORC1 mediated IL-6-induced Stat3 activation in intestinal epithelial cells to stimulate the expression of downstream targets essential for cell proliferation and tissue regeneration. Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulation of inflammation-... | yes |
converted_1848 | Is rucaparib used for ovarian cancer treatment? | While olaparib is the first PARP inhibitor to receive approval for ovarian cancer treatment, others including rucaparib and niraparib are clearly effective in this disease and, within the next year or two, the results of ongoing randomised trials will clarify their respective roles. , Similar trials with other PARP inh... | yes |
converted_1272 | Is curcumin a phytochemical? | we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals, The phytochemical, curcumin, has been reported to play many beneficial roles., Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chemopreventive p... | yes |
converted_3440 | Does teplizumab hold promise for diabetes prevention? | Anti-CD3 teplizumab and anti-CD3 otelixizumab have been shown to provide C-peptide preservation. , Underway are secondary prevention studies with teplizumab and with abatacept., INTERPRETATION: Findings of exploratory analyses suggest that future studies of immunotherapeutic intervention with teplizumab might have incr... | yes |
converted_4478 | Is Phospholemman a membrane protein? | the transmembrane lipoprotein phospholemman (FXYD1), Phospholemman (FXYD1) is a single-transmembrane protein regulator of Na,K-ATPase, expressed strongly in heart, skeletal muscle, and brain and phosphorylated by protein kinases A and C at Ser-68 and Ser-63, respectively., We previously identified FXYD1 (encoding phos... | yes |
converted_4165 | Is belimumab effective for the lupus nephritis? | Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results., CONCLUSIONS: Combined B-cell targeted therapy with RTX and BLM prevented full B-cell repopulation including DN B cells, with concomitant specific reduction of SLE-relev... | yes |
converted_1835 | Do statins cause diabetes? | Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic control in T2DM patients, The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of preventing ... | yes |
converted_3884 | Is there high nucleotide diversity in the Drosophila suzukii species? | Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here, we investigate the genetic population str... | yes |
converted_3042 | Is Semagacestat effective for treatment of Alzheimer's disease? | However, a large phase 3 trial of semagacestat, a potential non-transition state analog (non-TSA) GSI, in patients with Alzheimer's disease (AD) was terminated due to unexpected aggravation of cognitive deficits and side effects., BACKGROUND: In a recent report, 76 weeks' treatment with a gamma-secretase inhibitor (sem... | no |
converted_3928 | Is the Apis mellifera genome available? | Mining Apis mellifera sequences made it possible to identify the honey bee subspecies both at the mitochondrial and nuclear genome levels., Honey bee research is believed to be influenced dramatically by colony collapse disorder (CCD) and the sequenced genome release in 2006, but this assertion has never been tested.,... | yes |
converted_211 | Is long QT syndrome a cause for sudden cardiac death in athletes? | A diversity of cardiovascular disorders including hypertrophic cardiomyopathy, congenital coronary anomalies, arrhythmogenic right ventricular dysplasia, dilated cardiomyopathy, aortic rupture due to Marfan syndrome, myocarditis, valvular disease and electrical disorders (Wolff-Parkinson-White syndrome, long QT syndrom... | yes |
converted_1959 | Are Ultra-conserved elements (UCEs) enriched in segmental duplications? | Here we address the process by which CNVs become depleted of UCEs., We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are significantly depleted for UCEs., In strikin... | no |
converted_501 | Is Kanzaki disease associated with deficiency in alpha-N-acetylgalactosaminidase? | Kanzaki disease (OMIM#104170) is attributable to a deficiency in alpha-N-acetylgalactosaminidase (alpha-NAGA; E.C.3.2.1.49), which hydrolyzes GalNAcalpha1-O-Ser/Thr. , Our findings suggest that the association of alpha-NAGA with its substrates is strongly affected by the amino acid substitution at R329 and that the as... | yes |
converted_4559 | Is there an association between pyostomatitis vegetans and Crohn's disease? | Among the main oral manifestations of IBD are cobblestoning of the oral mucosa, labial swellings with vertical fissures, pyostomatitis vegetans, angular cheilitis, perioral erythema, and glossitis. , Pyostomatitis Vegetans: A Clue for Diagnosis of Silent Crohn's Disease., We present a case of Pyostomatitis vegetans inv... | yes |
converted_3970 | Does erenumab target the calcitonin gene-related peptide? | Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab).[SEP]Relations: CALCRL has relations: drug_protein with Erenumab, drug_protein with Erenumab, molfun... | no |
converted_169 | Are there any specific antidotes for rivaroxaban? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs., ... | no |
converted_653 | Is delayed enhancement documented in patients with non-ischemic dilated cardiomyopathy? | Myocardial fibrosis was present in 30% of patients, the majority of which was mid-myocardial (63%). , DCM patients frequently have myocardial fibrosis detected on CE-CMR, the majority of which is mid-myocardial., Fifty (40%) patients showed myocardial DE, representing 12±7% of LV mass., one case was dilated cardiomyop... | yes |
converted_2021 | Is siltuximab effective for Castleman disease? | Siltuximab: a targeted therapy for idiopathic multicentric Castleman disease., The recent approvals in North America, Europe and Brazil of siltuximab, a monoclonal antibody against IL-6, for iMCD now provide a safe and effective therapy that targets a key aspect of pathogenesis. In the first ever randomized, placebo-co... | yes |
converted_420 | Are messenger RNA molecules epigenetically methylated? | The most abundant mRNA post-transcriptional modification is N(6)-methyladenosine (m(6)A), which has broad roles in RNA biology., N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate., Recently, methylation patterns have also been revealed ... | yes |
converted_2327 | Is ACI-35 a passive vaccine? | Two active vaccines targeting either nonphosphorylated (AAD-vac1) and phosphorylated tau (ACI-35) have entered Phase I testing.[SEP] | no |
converted_3710 | Has ORMD-0801 been tested in patients? | Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study., In efforts to provide patients with a more compliable treatment method, Oramed Pharmaceuticals tested the capacity of its oral insulin capsule (ORMD-0801, 8 mg insulin) in addressing this res... | yes |
converted_2970 | Does allele phasing improve the phylogenetic utility of ultraconserved elements? | Allele Phasing Greatly Improves the Phylogenetic Utility of Ultraconserved Elements., Our empirical analyses of Ultraconserved Element (UCE) locus data collected from the South American hummingbird genus Topaza demonstrate that phased allele sequences carry sufficient phylogenetic information to infer the genetic struc... | yes |
converted_2933 | Is there a deep-learning algorithm for protein solubility prediction? | DeepSol: a deep learning framework for sequence-based protein solubility prediction., Protein solubility plays a vital role in pharmaceutical research and production yield. For a given protein, the extent of its solubility can represent the quality of its function, and is ultimately defined by its sequence. Thus, it is... | yes |
converted_3834 | Does the use of bDMARDs during pregnancy impact neonatal development? | Exposure to bDMARDs during pregnancy does not seem to interfere with post-natal development up to infancy., Long-term follow-up data about newborns exposed to bDMARDs during pregnancy are however scarce. [SEP] | no |
converted_1671 | Is LPS a microbial product? | and microbial translocation [lipopolysaccaride (LPS), microbial 16S rDNA and sCD14] , Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections, bacterial lipopolysaccharide (LPS), sterile bacterial wall lipopolysaccharide (LPS) to investigate the changes in inna... | yes |
converted_2316 | Can the CEP290 gene mutations be targeted by AAV-mediated gene therapy? | The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy.[SEP]Relations: CEP290 has relations: protein_protein with CEP43, protein_protein with CEP43, disease_protein with Joubert syndrome, disease_protein with Joubert syndrome, disease_protein with Joubert s... | no |
converted_545 | Have hESC been tested for the treatment of age-related macular degeneration? | Development of human embryonic stem cell therapies for age-related macular degeneration, In this review, we describe recent approaches to develop cell-based therapies for the treatment of AMD. Recent research has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell... | yes |
converted_2016 | Is ocular melanosis a risk factor for uveal melanoma? | Ocular/oculodermal (oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of uveal melanoma, estimated at 1 in 400 affected patients., Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every 6 or 12 ... | yes |
converted_3459 | Is the protein ABCG2 transmembrane? | the transmembrane ATP-binding cassette transporter G2, ATP-binding cassette (ABC) transporters are transmembrane efflux transporters mediating the extrusion of an array of substrates ranging from amino acids and lipids to xenobiotics, and many therapeutic compounds, including anticancer drugs., The ATP-binding cassette... | yes |
converted_1548 | Is the gene SLC6A2 associated with orthostatic intolerance? | Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. , Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intol... | yes |
converted_2668 | Is the protein pelota a ribosomal rescue factor? | a novel binding partner of the ribosome recycling protein Pelota, n eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation. , In eukaryotes, the protein complex of Pelota (yeast Dom34) and Hbs1 translational GTPase recognizes the stalled ribosome cont... | yes |
converted_2156 | Do circRNAs remain untranslated? | We demonstrate that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression, Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK... | no |
converted_1173 | Do Parkinson's disease patients experience stridor? | The authors describe a patient experiencing stridor and dysphagia with confirmed pulmonary restriction and aspiration following subthalamic nucleus deep brain stimulator adjustment, with a resolution of symptoms and signs when the stimulator was switched off., Stridor was not noted during sleep at night. Endoscopic exa... | yes |
converted_676 | Has proteomics been used in the study of Pick's disease? | In Pick's disease, increased AGE, CML, CEL, HNE and MDAL bands of about 50 kDa were observed in the frontal cortex (but not in the occipital cortex) in association with increased density of glial acidic protein bands., Thus, brain and cerebrospinal fluid (CSF) samples from patients with Alzheimer's disease, Down syndro... | yes |
converted_15 | Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer? | Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial., Our data demonstrate that Re-188-labeled Herceptin effectively inhibited the growth of DU145 cells compared to the Herceptin- and Re-188-treated cohorts. This implies... | yes |
converted_3465 | Are lamina-associated domains (LADs) associated with transcriptional activation? | Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains., Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes., Such lamina-associated dom... | no |
converted_1980 | Could divalent metal transporter 1 deficiency lead to anemia? | The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Loss of DMT1 function results in microcytic anemia. , Dysfunction of human DMT1 is associated with several pathologies such as iron deficiency anemia hemochromatosis, Parkinson's disease and Alzheimer's ... | yes |
converted_1510 | Is gastro esophageal reflux related to burning mouth syndrome? | Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients., As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS from those... | no |
converted_1302 | Does thyroid hormone signaling affect microRNAs expression in the heart? | e show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a., On the other hand, T₃ treatment increased miR-35... | yes |
converted_1409 | Does Apolipoprotein E (ApoE) have anti-inflammatory activity? | have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 ("classic") to M2 ("alternativ... | yes |
converted_1416 | Is c-myc subject to regulation by the circadian clock? | The current study encompasses the investigation of simultaneous expression of four circadian clock genes (Bmal1, Clock, Per1 and Per2) and three clock-controlled cell cycle genes (Myc, Cyclin D1 and Wee1), Our results suggest that aberrant expression of circadian clock genes can lead to aberrant expression of their dow... | yes |
converted_2598 | Does MC1R palmitoylation reduce pigmentation? | The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signalling and melanin production and enhances DNA repair after ultraviolet irradiation. , MC1R palmitoylati... | no |
converted_3414 | Is the protein MCL-1 anti-apoptotic? | increased expression of anti-apoptotic proteins (Bcl-xL, Mcl-1 and XIAP) , repression of anti-apoptotic proteins (Mcl-1, Bcl-xl and XIAP), anti-apoptotic BCL-2 family members, such as BCL-2, BCL-XL or MCL-1[SEP]Relations: BCL2L1 has relations: protein_protein with MCL1, protein_protein with MCL1, protein_protein with A... | yes |
converted_3704 | Does radiotherapy for prostate cancer increase bladder cancer risk? | External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis., On multivariable competing risk regression analyses, treatment with EBRT was independently associated with the risk of developing a second prima... | yes |
converted_1487 | Does Serca2a bind PLN in the heart? | The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase., Moreover, PLN-R14Del did not co-immunoprecipitate with SERCA2a (as did WT-PLN),, n this review, we attempted to highlight the functional significance of PLN in vertebrate cardiac physiology. We will refer to ... | yes |
converted_1395 | Does prudent diet reduce cardiovascular risk? | Using this approach, large prospective studies have reported reductions in CVD risk ranging from 10 to 60% in groups whose diets can be variously classified as ‘Healthy’, ‘Prudent’, Mediterranean’ or ‘DASH compliant’., Our findings suggest that a heart healthy dietary pattern is associated with moderately reduced risk ... | yes |
converted_1354 | Has the presence of delayed enhancement been documented in athletes performing strenuous exercise? | Atypical findings such as marked cardiac dilation, reduced deformation, or small patches of delayed gadolinium enhancement may be commonly encountered in well-trained athletes, but, at present, the prognostic significance of such findings is unknown. , On CMR, DGE localized to the interventricular septum was identified... | yes |
converted_3460 | Can radiotherapy cause radiation induced osteosarcoma? | A case of radiation-induced osteosarcoma of the skull presenting as a cutaneous epidermotropic tumor with a short latent period., Radiation-induced sarcoma (RIS) is an unusual but well documented tumor. , We report a case of a 34-year-old female who developed an osteosarcoma of the scalp, over a previous craniotomy sca... | yes |
converted_3189 | Have apolipoprotein mimetics been used in clinical trials? | One of these (AEM-28) has recently been given orphan drug status and is undergoing clinical trials.[SEP] | yes |
converted_3168 | Tocilizumab is an anti-TNF antibody, yes or no? | was treated with tocilizumab, an anti-interleukin-6 receptor monoclonal antibody , Tocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptor licensed in 2009 that has demonstrated clinical efficacy in various adult RA populations. RA management guidelines and recommendations consider TCZ as one of the ... | no |
converted_1343 | Are conserved noncoding elements associated with the evolution of animal body plans? | Here, we discuss the evidence that CNEs are part of the core gene regulatory networks (GRNs) that specify alternative animal body plans. The major animal groups arose>550 million years ago. We propose that the cis-regulatory inputs identified by CNEs arose during the "re-wiring" of regulatory interactions that occurred... | yes |
converted_3810 | Can AGY be used as antidiuretic replacement therapy? | AGY, a Novel Egg Yolk-Derived Anti-gliadin Antibody, Is Safe for Patients with Celiac Disease., Oral egg yolk anti-gliadin antibody (AGY) is a novel treatment to neutralize gluten and may improve the efficacy of the GFD., To determine the safety, tolerability, and potential efficacy of AGY in patients with CD., Most pa... | no |
converted_4351 | Are circRNAs susceptible to degradation by RNase R? | Currently, an increasing body of evidence has demonstrated that 1) majority of circRNAs are evolutionarily conserved across species, stable, and resistant to RNase R degradation, , Circular RNA (circRNA) has a closed-loop structure, and its 3' and 5' ends are directly covalently connected by reverse splicing, which is ... | no |
converted_2846 | Is phospholipid hydroperoxide glutathione peroxidase a selenoprotein? | Glutathione peroxidase (Gpx1) is the major selenoprotein in most tissues in animals., The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation., the major selenoprotein expressed by germ cells in the testis, the phospholipid hydroperoxide gl... | yes |
converted_3602 | Has istadefylline been considered as a treatment for Parkinson's disease? | Istradefylline (ISD) is a new drug developed for the treatment of Parkinson's disease (PD). It is an adenosine receptor A2A antagonists that will represent an important option for patients with advanced PD where it has been demonstrated efficacy in decreasing daily OFF time and is well tolerated. , The objective of thi... | yes |
converted_367 | Is bapineuzumab effective for treatment of patients with Alzheimer's disease? | Thus far, results from two large phase 3 trial programs with bapineuzumab and solaneuzumab, respectively, have brought rather disappointing results., More recently, in phase III studies, bapineuzumab has been discontinued because it did not prove clinically effective (despite its significant effect on biomarkers), whi... | no |
converted_577 | Is paramyxovirus involved in human subacute thyroiditis? | Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Barr virus, and adenovirus. Influenza immunization or infection may cause subacute thyroiditis., Coxsackie virus has been reported to be one of the viruses associated with the disease., The etiology o... | no |
converted_1948 | Do IEG create a ripple effect of transcription? | Rapid induction of immediate-early genes (IEGs) in response to growth factor stimulations is accompanied by co-upregulation of their neighbouring genes., Even in surrounding intergenic regions, transcriptional activation took place at the same time. , Here we show that intensive transcription at one locus frequently sp... | yes |
converted_3489 | Can radiation induced meningiomas be treated with radiosurgery? | This is a case report of a patient treated with radiosurgery for radiation induced meningiomas, 30 years after childhood whole brain radiation. , This article reviews the unique characteristics and unusual response to the radiation induced meningiomas to radiosurgery. , Gamma knife stereotactic radiosurgery for radiati... | yes |
converted_1523 | Can siRNA affect response to afatinib treatment? | On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab), These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation), but were... | yes |
converted_4634 | Is HDAC1 required for GATA-1 transcriptional activity? | HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis., GATA-12RA knock-in (KI) mice suffer mild anemia and thrombocytopenia with accumulation of immature erythrocytes and megakaryocytes in bone marrow and spleen. Single cell RNA-seq analysis of Lin- cKit+ (LK) cells further ... | yes |
converted_259 | Is oxidative stress affected by FOXO expression? | Forkhead-box class O (FoxO) transcription factors regulate mechanisms of cellular aging, including protein quality control, autophagy and defenses against oxidative stress., Statin-mediated upregulation of klotho expression and differential regulation of FoxO expression promote resistance to CsA-induced oxidative stres... | yes |
converted_1468 | Is it possible to determine the proteome of a formalin fixed and paraffin embedded (FFPE) tissue? | ver the last few years, advances in methodology have made it possible to recover peptides from FFPE tissues that yield a reasonable representation of the proteins recovered from identical fresh or frozen specimens., Thus, laser capture microdissection of FFPE tissue coupled with downstream proteomic analysis is a valid... | yes |
converted_4585 | Are Tregs CD4(+)CD25(+) regulatory T cells a positive regulator of the immune response? | The immunosuppressive effects of CD4+ CD25 high regulatory T cells (Tregs) interfere with antitumor immune responses in cancer patients., Alteration of regulatory T cells (Tregs) may contribute to ineffective suppression of proinflammatory cytokines in type 1 diabetes.AIM, Regulatory T cells (Tregs) suppress excessive ... | no |
converted_2789 | Can gene therapy restore auditory function? | Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c., We demonstrate recovery of gene and protein expression, restoration of sensory cell function, rescue of complex auditory function and recovery of hearing and balance behavior to near wild-type levels. The data represent ... | yes |
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