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converted_634 | Could Arimidex (anastrozole) cause hot flashes? | More than a third of breast cancer patients undergoing aromatase inhibitor (AI) treatment report joint pain., In the first 6 weeks, emergence of joint pain was associated with increase in general pain, fatigue, disturbed sleep, hot flashes, vaginal dryness, and decreased sexual activity., Antiestrogen therapy can cause... | yes |
converted_573 | Are there telemedicine applications for chronic pain management? | An integrated cognitive-behavioral and physical therapy group protocol has been developed and then implemented at remote sites using videoconferencing technology to provide pain management for veterans. , Tele-pain management: use of videoconferencing technology in the delivery of an integrated cognitive-behavioral and... | yes |
converted_2282 | Is dasatinib effective for treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_300 | Is alternative splicing of apoptotic genes playing a role in the response to DNA or mitochondrial damage? | Apoptosis promoted by UV in cells lacking p53 is prevented when the change in AS of the apoptotic gene bcl-x is reverted, confirming the relevance of this mechanism., We demonstrate that E2F1 requires SC35 to switch the alternative splicing profile of various apoptotic genes such as c-flip, caspases-8 and -9 and Bcl-x,... | yes |
converted_3371 | Does clinical trial data support the use of minocycline for amyotrophic lateral sclerosis? | Two double-blind, randomized, placebo-controlled feasibility trials of minocycline in ALS were conducted. , This pilot study shows that minocycline and riluzole can be taken safely together. Further trials are needed to assess efficacy of such treatment., It reduces apoptosis in mouse models of Huntington's disease and... | no |
converted_4120 | Are Gram positive bacteria able to release extracellular vesicles? | Gram-negative and Gram-positive bacteria release a variety of membrane vesicles through different formation routes. , Release of extracellular vesicles (EVs) is a common feature among eukaryotes, archaea, and bacteria. However, the biogenesis and downstream biological effects of EVs released from gram-positive bacteria... | yes |
converted_245 | Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | Gene regulation in Drosophila spermatogenesis: analysis of protein binding at the translational control element TCE., We have previously identified a 12 nucleotide long sequence element, the TCE, that was demonstrated to be necessary for translational control of expression in the male germ line of Drosophila melanogast... | yes |
converted_3245 | Is the Fluzone intradermal and the Fluzone intradermal quadrivalent vaccine produced by different companies? | An intradermal version of Fluzone® split-virion inactivated trivalent influenza vaccine, containing 9 µg hemagglutinin per strain of A/H1N1, A/H3N2, and one B lineage virus (Fluzone Intradermal, Sanofi Pasteur), became available in the US during the 2011-2012 influenza season for adults 18-64 years of age. In advance o... | no |
converted_4351 | Are circRNAs susceptible to degradation by RNase R? | Currently, an increasing body of evidence has demonstrated that 1) majority of circRNAs are evolutionarily conserved across species, stable, and resistant to RNase R degradation, , Circular RNA (circRNA) has a closed-loop structure, and its 3' and 5' ends are directly covalently connected by reverse splicing, which is ... | no |
converted_384 | Is nintedanib effective for Idiopathic Pulmonary Fibrosis? | In this review, we present the positive results of recently published clinical trials regarding therapy for IPF, with emphasis on pirfenidone and nintedanib., Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis, In the Phase II TOMORROW trial, treatment with 150 mg of nintedanib twice d... | yes |
converted_4433 | Should perampanel be used for amyotrophic lateral sclerosis? | RESULTS: Six participants were enrolled. All had adverse events, mostly behavioral. Two completed the trial and the other four withdrew due to adverse events. All participants reported resolution of these events after discontinuation of the drug. The trial was halted due to the large number of adverse events.DISCUSSION... | no |
converted_1861 | Is treatment resistant depression related to vitamin B9? | Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agents in ... | yes |
converted_2592 | Are there sex differences in the transcriptome of the mouse hippocampus? | To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively., The bulk of these differ... | yes |
converted_4439 | Are circular RNAs implicated in diseases of the eye? | n this review, we summarized the function of circRNAs and indicated their roles in the pathogenesis of DR, which may provide new therapeutic targets for clinical treatment., This study aimed to determine whether circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for proliferative d... | yes |
converted_4148 | Is the glucocorticoid receptor a transcription factor? | GR and KLF4, both pioneer transcription factors,, The glucocorticoid receptor (GR) is a ligand-binding dependent transcription factor that ultimately regulates vital biological processes and inflammation response through specific gene expression control, thus representing a notable drug target to explore. , The glucoco... | yes |
converted_3339 | Can MVA85A confer immunity against smallpox? | We assessed the safety, immunogenicity, and efficacy of a candidate tuberculosis vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), in adults infected with HIV-1., Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised,... | no |
converted_3348 | Is Figitumumab effective for non-small cell lung cancer? | A phase III study failed for carboplatin, paclitaxel, with or without figitumumab in first-line treating metastatic non-small cell lung cancer (NSCLC)., CONCLUSION: Adding figitumumab to standard chemotherapy failed to increase OS in patients with advanced nonadenocarcinoma NSCLC., Median OS was 8.6 months for figitumu... | no |
converted_2670 | The TRPM2 gene is associated with development of spontaneous thromboembolism? | TheTransientReceptorPotentialMelastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. TRPM2 is involved in Ca2+signaling in various cells as an endogenous redox sensor for o... | no |
converted_724 | Are there any clinical trials of the effect of evening primrose oil on postmenopausal symptoms ? | To analyze whether the time (morning/evening) of administration of a compound containing 60 mg of dry soy seed extract (glycine max) with 40% of total isoflavones, primrose oil and α-tocopherol modifies the effect on the climacteric syndrome., The object of this study was to evaluate the effect of different doses of a ... | yes |
converted_1414 | Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collision... | no |
converted_249 | Does burning mouth syndrome preferentially affect post-mepopausal women? | It is observed principally in middle-aged patients and postmenopausal women and may be accompanied by xerostomia and altered taste., It occurs more commonly in middle-aged and elderly women and often affects the tongue tip and lateral borders, lips, and hard and soft palate. , BMS is a chronic disorder that frequently ... | yes |
converted_2617 | Is there a link between nuclear position and DNA repair pathway choice? | Nuclear position dictates DNA repair pathway choice., We demonstrate that DSBs induced at the nuclear membrane (but not at nuclear pores or nuclear interior) fail to rapidly activate the DNA damage response (DDR) and repair by homologous recombination (HR). Real-time and superresolution imaging reveal that DNA DSBs wit... | yes |
converted_3012 | Is pimavanserin effective for Parkinson's disease psychosis? | Two cases of Parkinson's disease with an unusual delusional misidentification, intermetamorphosis, are presented, along with their improvement with pimavanserin, a novel atypical antipsychotic medication., RATIONALE: Pimavanserin, a selective serotonin 2A receptor inverse agonist, is a promising candidate for treating ... | yes |
converted_4053 | Does hypofractionated radiotherapy offers any benefit for DIPG? | CONCLUSION: Hypofractionated RT for children with newly diagnosed DIPG is well tolerated and feasible from the viewpoint of reducing a patient's burden of treatment. Re-irradiation at first progression is suggested to be beneficial., Median OS and time to progression were similar between conventionally fractionated and... | no |
converted_1394 | Are shadow enhancers associated with development? | Critical developmental control genes sometimes contain "shadow" enhancers that can be located in remote positions, including the introns of neighboring genes, These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-res... | yes |
converted_1360 | Is triadin involved in cardiac function? | Junctin (JCN), a 26-kd sarcoplasmic reticulum (SR) transmembrane protein, forms a quaternary protein complex with the ryanodine receptor, calsequestrin, and triadin in the SR lumen of cardiac muscle. Within this complex, calsequestrin, triadin, and JCN appear to be critical for normal regulation of ryanodine receptor-m... | yes |
converted_933 | Are patients with marfan syndrome at increased risk of arrhythmias? | Marfan syndrome (MFS) is a variable, autosomal-dominant disorder of the connective tissue. In MFS serious ventricular arrhythmias and sudden cardiac death (SCD) can occur., Marfan's patients carry increased risk for cardiac arrhythmias. , Ventricular arrhythmias were present in 21% and were associated with increased le... | yes |
converted_3544 | Is AND-1/Ctf4 essential for proliferation? | AND-1 fork protection function prevents fork resection and is essential for proliferation., AND-1/Ctf4 bridges the CMG helicase and DNA polymerase alpha, facilitating replication. Using an inducible degron system in avian cells, we find that AND-1 depletion is incompatible with proliferation, owing to cells accumulatin... | yes |
converted_124 | Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | DITPA normalized the elevated serum T(3) and TSH when the dose reached 1 mg/kg · d and T(4) and rT(3) increased to the lower normal range., The identification of 3,5-diiodothyropropionic acid (DITPA) that binds to both α- and β-type TRs with relatively low affinity was unique in that this analog improves left ventricul... | yes |
converted_1674 | Has field-programmable gate array (FPGA) technology been used to solve sequence alignment problems? | A linear error model for the raw intensity data and Burrows-Wheeler transform (BWT) based alignment are combined utilizing a Bayesian score function, which is then globally optimized over all possible genomic locations using an efficient branch-and-bound approach. The algorithm has been implemented in soft- and hardwar... | yes |
converted_1978 | Do histone variant mH2A (macro-H2A) levels decrease upon differentiation? | Through manipulation of macroH2A isoforms, we further demonstrate that macroH2A2 is the predominant barrier to reprogramming., In particular, we find macroH2A isoforms to be highly enriched at target genes of the K27me3 demethylase, Utx, which are reactivated early in iPS reprogramming, Therefore, we propose that macr... | no |
converted_2512 | Is celiac disease caused by gliadin-induced transglutaminase-2 (TG2)-dependent events ? | Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. , Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response to... | yes |
converted_1910 | Could plasmepsins be used as targets for developing anti-malaria drugs? | Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors., Given that the parasite needs the resulting amino acid building blocks for its growth and development, plasmepsins are an important antimalarial drug target. , Due to early crystallographic evidence, plasmepsin II (Plm II) emerged... | yes |
converted_3273 | Has the drug Afrezza been approved by the FDA? | In contrary, MannKind Corporation started developing its ultra-rapid-acting insulin Afrezza in a bold bid, probably by managing the issues in which Exubera was not successful. Afrezza has been marketed since February, 2015 by Sanofi after getting FDA approval in June 2014.[SEP]Definitions: bid defined as following: Two... | yes |
converted_1369 | Are microRNA (miR) regulated through DNA methylation of their promoters? | We found that Tcf3 down-regulation in the context of constitutively active Wnt signaling does not result from promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (H3K4me3 and H3-acetylation) and t... | yes |
converted_2128 | Is Beta-Thalassemia is associated with a mutation or deletion of the gene that codes for alpha globin? | Beta-thalassemia, one of the most common single-gene disorders, is the result of reduced or absent production of β-globin chains, The beta-thalassemia syndromes are a heterogeneous group of genetic disorders characterized by reduced or absent expression of the beta-globin gene[SEP]Definitions: Beta-thalassemia defined ... | no |
converted_1102 | Is cocaine use associated with increased risk for intracerebral hemorrhage? | Stroke in crack-cocaine abusers is increasingly recognized., There were significant differences between crack-cocaine cases and controls in age (48.7 years vs. 55 years) (P = 0.0001), male gender (65.6% vs. 40.9%) (odds ratios, OR = 1.64, 95% CI 1.22-2.21), arterial hypertension (61.1% vs. 83.9%) (OR = 0.30, 95% CI 0.1... | yes |
converted_2657 | Are AAV vectors considered for the treatment of retinal dystrophies? | These novel gene vectors aim to more safely and efficiently transduce retinal cells, expand the gene packaging capacity of AAV, and utilize new strategies to correct the varying mechanisms of dysfunction found with inherited retinal dystrophies. [SEP]Definitions: retinal dystrophies defined as following: A group of di... | yes |
converted_3132 | Can you computationally predict Molecular Recognition Features (MoRFs) regions in Intrinsically Disordered Proteins (IDPs)? | Predicting Functions of Disordered Proteins with MoRFpred., Intrinsically disordered proteins and regions are involved in a wide range of cellular functions, and they often facilitate protein-protein interactions. Molecular recognition features (MoRFs) are segments of intrinsically disordered regions that bind to partn... | yes |
converted_3792 | Is tocilizumab a csDMARD? | The task force agreed on 5 overarching principles and 12 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GCs); biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, inflixim... | no |
converted_2357 | Is Kummell’s disease an avascular necrosis of the vertebral body? | Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterised by the gradual development in time of a vertebral body collapse following a trivial spinal trauma, involving a worsening back pain associated with a progressive kyphosis., Kumme... | yes |
converted_4697 | Is disruption of immune regulation mechanisms associated with adverse pregnancy outcomes, including preeclampsia (PE)? | Maternal systemic and placental inflammatory responses participate in the pathogenesis of hypertensive disorders of pregnancy including preeclampsia, a pregnancy-specific syndrome, although the role of inflammation remains unclear. , Our results indicate these proteins are new factors that play important roles in the ... | yes |
converted_1447 | Has silicon been used in treatment of incontinence ? | an artificial anal sphincter. Worldwide, there are two established devices on the market: the artificial bowel sphincter® (ABS) from A. M. S. (Minnetonka, MN, USA) and the soft anal band® from A. M. I. (Feldkirch, Austria). How to implant the artificial anal sphincter? Both devices consist of a silicon cuff which can b... | yes |
converted_1917 | Is there a role for gamma knife in treatment of Obsessive-Compulsive Disorder? | OBJECTIVE Functional Gamma Knife radiosurgery (GKRS) procedures have been increasingly used for treating patients with tremor, trigeminal neuralgia (TN), and refractory obsessive-compulsive disorder., METHODS The authors constructed a linear-quadratic model of BED in functional GKRS with a dose-protraction factor to co... | yes |
converted_2176 | Is dexamethasone recommended for treatment of intracerebral hemorrhage? | Dexamethasone and other glucocorticoids should be avoided. , During the third interim analysis, the death rate at the 21st day was identical in the two groups (dexamethasone vs. placebo, 21 of 46 vs. 21 of 47; chi-square = 0.01, P = 0.93). In contrast, the rate of complications (mostly infections and complications of d... | no |
converted_2637 | Is there a disease or condition called Exploding Head Syndrome? | This case report describes the first-ever diagnosis of exploding head syndrome in a patient with longstanding epilepsy and novel nocturnal events. , Exploding head syndrome (EHS) is characterized by loud noises or a sense of explosion in the head during sleep transitions., Exploding head syndrome is characterized by th... | yes |
converted_2049 | Are the genes for marneral biosynthesis scattered in the genome of A. thaliana? | Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary events that have led to cluster formation, Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thalia... | no |
converted_1092 | Does amiodarone affect thyroid hormone receptors in the myocardium? | AM and Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50%, In the LVW, AM and Dron decreased TRbeta 1 and, interestingly, AM increased TRalpha 1., n the apex, AM also increased TRalpha 2., Both in treated and untreated mice, TRalpha2 mRNA had the highest density i... | yes |
converted_1542 | Is thyroid hormone therapy indicated in patients with heart failure? | Patients with chronic heart failure and subclinical hypothyroidism significantly improved their physical performance when normal TSH levels were reached., Early and sustained physiological restoration of circulating L-T3 levels after MI halves infarct scar size and prevents the progression towards heart failure. This b... | no |
converted_3383 | AhR ligands are attractive drug targets for pharmaceutical development due to their induction of Cyp1a1, yes or no? | Based on our review of the data, there is little evidence to support the indiscriminate exclusion of AhR activators/Cyp1a1 inducers from early drug developmental pipelines. We also found no evidence that short-term treatment with RMAhRLs produce "dioxin-like toxicity", However, recent discoveries of new AhR ligands wi... | yes |
converted_2259 | Does TUC.338 inhibit colorectal cancer? | TUC.338 promotes invasion and metastasis in colorectal cancer., Until now, the role of TUC.338 in colorectal cancers remains undefined. This study revealed that TUC.338 is significantly up-regulated in colorectal cancers (CRC) tissue and CRC cell lines, and the up-regulated TUC.338 is associated with lymph node metasta... | no |
converted_1901 | Is there any role for Pds5b in cohesion establishment? | Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres., Here, we demonstrate that Pds5 proteins are essential for cohesion establishment by allowing Smc3 acetylation by the cohesin acetyl transferases (CoATs) Esco1/2 and binding of Sororin. While both proteins contribute to telomere and ... | yes |
converted_1486 | Does ventriculoperitoneal shunt improve normal pressure hydrocephalus? | Clinical improvement depends not only on the capability to restore the cerebrospinal fluid dynamic, but also on the ability of cerebral parenchyma to recover the metabolic function., After shunting, the global CMRglu significantly increased (2.95 ± 0.44 vs 4.38 ± 0.68, p = 10(-7)) in all INPH patients with a mean perc... | yes |
converted_3856 | Does an antiphlogistic promotes inflammation? | The therapeutic effect of olipiphate was demonstrated for chronic inflammation of advanced arthritis and concanavalin A-related acute edema. The best systemic effect was obtained with 50 mg/kg, symptomatic--100 mg/kg. Skin wounds treated with 5% olipiphate (26 + 2) healed faster than those treated with 2% solcoseryl (3... | no |
converted_848 | Is there a pharmacogenetic test for trastuzumab? | The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing., the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therap... | yes |
converted_2271 | Is davunetide being considered for the treatment of progressive supranuclear palsy? | Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy., Davunetide's efficacy and tolerability are being tested in a placebo-controlled study in PSP patients, making it the most advanced drug candidate in this indication. This review examines the disease characteristics of PSP,... | yes |
converted_4585 | Are Tregs CD4(+)CD25(+) regulatory T cells a positive regulator of the immune response? | The immunosuppressive effects of CD4+ CD25 high regulatory T cells (Tregs) interfere with antitumor immune responses in cancer patients., Alteration of regulatory T cells (Tregs) may contribute to ineffective suppression of proinflammatory cytokines in type 1 diabetes.AIM, Regulatory T cells (Tregs) suppress excessive ... | no |
converted_4695 | Was ALVAC-HIV effective for HIV prevention in the HVTN 702 trial? | During the 24-month follow-up, HIV-1 infection was diagnosed in 138 participants in the vaccine group and in 133 in the placebo group (hazard ratio, 1.02; 95% confidence interval, 0.81 to 1.30; P = 0.84).CONCLUSIONS: The ALVAC-gp120 regimen did not prevent HIV-1 infection among participants in South Africa despite prev... | no |
converted_2790 | Is the PINES framework being used for the prediction of coding variants? | PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants., Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the functional impact of noncoding variants by integrating epigenetic annotations in a phenotype-dependent... | no |
converted_1000 | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | PTH can induce skeletal synthesis of another potent phosphaturic hormone, fibroblast growth factor 23 (FGF23), , Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that has recently been identified as a CKD-related factor affecting CRS. , circulating phosphaturic hormone fibroblast growth factor-23 levels,... | yes |
converted_253 | Can life style changes reduce oxidative stress | The CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis. Antioxidant treatment and life style changes are indicated ... | yes |
converted_402 | Is paroxetine effective for treatment of premenstrual dysphoric disorder? | To evaluate the cost effectiveness of the four medications with a US FDA-approved indication for PMDD: fluoxetine, sertraline, paroxetine and drospirenone plus ethinyl estradiol (DRSP/EE)., All SSRIs (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and clomipramine) were effective in reducing premenstrual ... | yes |
converted_1778 | Is NADPH oxidase 5 expressed in rodents? | Because the Nox5 gene is absent in rodents, we generated transgenic mice expressing human Nox5 in a podocyte-specific manner (Nox5(pod+)). , The NADPH oxidase 5 (NOX5) gene is present in humans but not rodents. , The data document that the NOX5 gene was expressed in cells of lagomorphs unlike rodents, making the rabbit... | no |
converted_2791 | Is erythropoietin effective for treatment of amyotrophic lateral sclerosis? | This study was performed to validate the ALS-MITOS as a 6-month proxy of survival in 200 ALS patients followed up to 18 months.METHODS: Analyses were performed on data from the recombinant human erythropoietin RCT that failed to demonstrate differences between groups for both primary and secondary outcomes., CONCLUSION... | no |
converted_3396 | Autophagy is the process where a virus obtains nutrients from it's host, yes or no? | In this study, we demonstrate that autophagy is a critical mediator of the viral degradation pathway and that this pathway is not HIV-1 specific., Autophagy is important in cellular homeostasis for the cell survival mechanism., Autophagy is a cellular survival pathway that is necessary for the degradation of cellular c... | no |
converted_653 | Is delayed enhancement documented in patients with non-ischemic dilated cardiomyopathy? | Myocardial fibrosis was present in 30% of patients, the majority of which was mid-myocardial (63%). , DCM patients frequently have myocardial fibrosis detected on CE-CMR, the majority of which is mid-myocardial., Fifty (40%) patients showed myocardial DE, representing 12±7% of LV mass., one case was dilated cardiomyop... | yes |
converted_3145 | Can TAD disruption lead to disease? | its perturbation will lead to human disease, highlighting the accumulating evidence that links the diverse 3D genome architecture components to a multitude of human diseases and the emerging mechanisms by which 3D genome derangement causes disease phenotypes., TAD boundaries are insulators of genomic neighborhoods. In ... | yes |
converted_839 | Are seizures among the neurological symptoms of incontinentia pigmenti? | High-dose glucocorticoid therapy in the management of seizures in neonatal incontinentia pigmenti, Incontinentia pigmenti is an X-linked dominant disorder resulting from a mutation of IKBKG. This disorder has a classic dermatologic presentation, but neurologic involvement, with seizures and cortical infarction, can ari... | yes |
converted_1701 | Is the protein KCNQ2 associated with idiopathic epilepsy? | Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated ... | yes |
converted_2755 | Is Baloxavir effective for influenza? | Baloxavir marboxil (Xofluza™; baloxavir) is an oral cap-dependent endonuclease inhibitor that has been developed by Roche and Shionogi. The drug blocks influenza virus proliferation by inhibiting the initiation of mRNA synthesis. In February 2018, baloxavir received its first global approval in Japan for the treatment ... | yes |
converted_3937 | Are mucins glycosylated proteins? | Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion., Mucin is a glycoprotein that is the primary component of the mucus overlaying the epithelial tissues. ... | yes |
converted_3486 | Are there lncRNAs that control the extent of neuronal outgrowth? | Regulation of Neuroregeneration by Long Noncoding RNAs., Here, we profiled gene expression following sciatic nerve crush in mice and identified long noncoding RNAs (lncRNAs) that act in the regenerating neurons and which are typically not expressed in other contexts. We show that two of these lncRNAs regulate the exten... | yes |
converted_3744 | Has tocilizumab been assessed against Covid-19? | Preliminary clinical results have indicated that antagonism of the IL-6 receptor (IL-6R), including with the FDA-approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID-19 while maintaining a good safety profile.[SEP]Definitions: IL-6 receptor defined as fo... | yes |
converted_1535 | Are immune cells affected in Amyotrophic Lateral Sclerosis? | Therapeutic immunization of mSOD1 mice with a myelin-derived peptide led to CP activation, and was followed by the accumulation of immunoregulatory cells, including IL-10-producing monocyte-derived macrophages and Foxp3(+) regulatory T cells, and elevation of the neurotrophic factors IGF-1 and GDNF in the diseased spin... | yes |
converted_1365 | Is Mammaprint approved by the United States Food and Drug Administration? | an FDA-cleared 70-gene signature of MammaPrint panel , on MammaPrint, the first and only assay for breast cancer management that has been cleared by the FDA., The MammaPrint assay has the advantages of a 510(k) clearance by the US Food and Drug Administration, a larger gene number which may enhance further utility, and... | yes |
converted_2316 | Can the CEP290 gene mutations be targeted by AAV-mediated gene therapy? | The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy.[SEP] | no |
converted_3336 | Are genomic regulatory blocks (GRBs) any different than TADs? | Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation., Clusters of CNEs define the span of regulatory inputs for many important developmental regulators and have been described previously as genomic regulatory blocks (GRBs). Their function and dis... | no |
converted_334 | Is exome sequencing efficient for the detection of germline mutations? | Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas, Whole exome sequencing is sensitive, rapid and efficient for detection of PCC/PGL germline mutations., These results from deep sequencing demonstrate a higher mutational... | yes |
converted_1950 | Do T-Cells regulate neuropathic pain? | here is evidence for a considerable impact of the immune system also in neuropathic pain. However, the role of the adaptive immune system is still unclear., Our investigation revealed a clear shift of T-cell subsets towards anti-inflammation in patients with neuropathic pain. , GITRL expressed on macrophages drives c... | yes |
converted_3151 | Can oleuropein aglycone interfere with amyloid aggregation? | Oleuropein, a phenolic secoiroid glycoside, is the main polyphenol in the olive oil. It has been reported that the aglycone form of Oleuropein (OleA) interferes in vitro and in vivo with amyloid aggregation of a number of proteins/peptides involved in amyloid, particularly neurodegenerative, diseases avoiding the growt... | yes |
converted_1013 | Is farnesoid X receptor (FXR) a nuclear receptor? | Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism, Farnesoid X receptor (FXR) is an ascending target for metabolic and infl... | yes |
converted_3695 | Are Chernobyl survivors at increased risk for breast cancer? | Results: A more aggressive course of breast cancer is observed in patients exposed to radiation from the Chernobyl accident under the age of 30 years (P < .01). , A significant excess of multiple myeloma incidence [standardized incidence rate (SIR) 1.61 %, 95% confidence interval (CI) 1.01-2.21], thyroid cancer (SIR 4.... | yes |
converted_4277 | Αre plants from the genus Strychnos the original source of curare? | Poisons are widespread in plants and animals and humankind has often tried to turn them to its own advantage. Owing to their poisonous properties, some species of Strychnos genus have been employed mainly in hunting and fishing, as an adjunct to weapons used not only in the search of food and clothes, but also for prev... | yes |
converted_2277 | Are TAD boundaries in Drosophila depleted in highly-expressed genes? | Furthermore, we find that these TAD boundaries are present irrespective of the expression and looping of genes located between them., In particular, Hi-C revealed that chromosomes of animals are organized into topologically associating domains (TADs), evolutionary conserved compact chromatin domains that influence gene... | no |
converted_4586 | Is Mediator present at super enhancers? | BRD4 and Mediator were found to co-occupy thousands of enhancers associated with active genes., Master transcription factors and mediator establish super-enhancers at key cell identity genes, Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expr... | yes |
converted_1215 | Is zolpidem an antibiotic? | Zolpidem is a short-acting imidazopyridine hypnotic drug that is metabolized mainly by CYP3A4., FGIN-1-27 and alpidem, like the neurosteroid 3 alpha,21-dehydroxy-5 alpha-pregnane-20-one (THDOC), clonazepam and zolpidem (the direct allosteric modulators of gamma-aminobutyric acidA receptors) delay the onset of isoniazid... | no |
converted_2246 | Is NEMO a zinc finger protein? | To better understand the thermodynamics and dynamics of the zinc finger of NEMO (NF-κB essential modulator), an alteration in the zinc finger domain of NEMO (K392R) , CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis., our simulations of the zinc finger NEMO, An important re... | yes |
converted_1489 | Is there any role for long noncoding RNAs in adipogenesis? | Long noncoding RNAs regulate adipogenesis., Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound ... | yes |
converted_4283 | Is AZD9668 a VEGF mRNA drug? | AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD., AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses of 60 mg bid during Phase I/IIa development.[SEP]Definitions: bid defined as following: Two times per day, at unspecified times.. neutrophil... | no |
converted_1526 | Is there an association between presenteeism and depression? | Presenteeism was positively associated with severity of depression (Health and Work Performance Questionnaire, P < 0.0001; WPAI, P < 0.0001)., Statistically significant correlations (0.32-0.53) were found between presenteeism and increasing disability, fatigue, depression, anxiety, and reduced quality of life. , Presen... | yes |
converted_2491 | Has ATF4 transcription factor been linked to cancer and neoplastic transformation? | aken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC, s a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2... | yes |
converted_4422 | Is pRETRO-SUPER an adenoviral vector? | In this study, we investigated the effect of small interfering RNA (siRNA) of connective tissue growth factor (CTGF) by pRetro-Super (PRS) retrovirus vector on the expression of CTGF and related extracellular matrix molecules in human renal proximal tubular cells (HKCs) induced by high glucose, to provide help for ren... | no |
converted_3812 | Can secondary glioblastoma be caused by brain irradiation? | Prolonged survival in secondary glioblastoma following local injection of targeted alpha therapy with , [Radiation induced glioblastoma: a case report]., We report a surgical case of a 54-year-old woman with a radiation induced glioblastoma., Glioblastoma multiforme following cranial irradiation and chemotherapy for ac... | yes |
converted_3344 | Is marimastat effective for small-cell lung cancer? | The phase III trial in small cell lung cancer was discontinued when the results of study 140 were released in February 2001 showing that marimastat was not significantly more effective than placebo in prolonging the survival of small cell lung cancer patients., CONCLUSION: Treatment with marimastat after induction ther... | no |
converted_4291 | Is histone variant H3.3K27M associated with gliomas? | Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling., Well-known oncohistones, with mutations on both H3.1 and H3.3, include H3K36M in chondroblastoma, H3K27M in glioma, Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children w... | yes |
converted_1507 | Do thyroid hormone receptors change after brain injury? | For example, the T3 receptor alpha was predominantly expressed in stroke-tissue, indicating that regeneration of nerves in stroke tissue may be facilitated by increased T3 receptor alpha expression., TRα expression was also increased in human infants with IVH. , Thus, in infants with IVH the combined elevation in deiod... | yes |
converted_3959 | Are PDXK mutations linked to polyneuropathy? | PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation., To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy.METHODS: We performed genome-wide sequencing, homozygosity mapping, and segregation ana... | yes |
converted_1345 | Are DNA methylation maps applicable to the diagnosis of non-small-cell lung carcinomas? | Here we present a genome-wide DNA methylation analysis of NSCLC samples and paired lung tissues, where we combine MethylCap and next generation sequencing (MethylCap-seq) to provide comprehensive DNA methylation maps of the tumor and paired lung samples., Analysis of the MethylCap-seq data revealed a strong positive co... | yes |
converted_47 | Is Weaver syndrome similar to Sotos? | Overgrowth conditions are a heterogeneous group of disorders characterised by increased growth and variable features, including macrocephaly, distinctive facial appearance and various degrees of learning difficulties and intellectual disability. Among them, Sotos and Weaver syndromes are clinically well defined and due... | yes |
converted_1929 | Can NADPH oxidase be inhibited by apocynin and diphenylene iodonium? | Ang II treatment also led to a significant increment in intracellular reactive oxygen species generation, which could be fully abolished by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors apocynin or diphenylene iodonium, indicating that Ang II enhanced oxidative stress via a NADPH oxidase-depend... | yes |
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