original_question stringlengths 20 192 | id stringlengths 11 14 | sentence1 stringlengths 23 217 | sentence2 stringlengths 87 25.9k | label stringclasses 2
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Does amiodarone affect thyroid hormone receptors in the myocardium? | converted_1092 | Does amiodarone affect thyroid hormone receptors in the myocardium? | ATF7IP wt Allele and Dron affected Tricuspid Valve Insufficiency expression in the Rheumatoid Arthritis similarly by decreasing TRalpha 1 and beta 1 expression by about 50%, In the LVW, ATF7IP wt Allele and Dron decreased THRB gene and, interestingly, ATF7IP wt Allele increased TRalpha 1., n the apex, ATF7IP wt Allele ... | yes |
Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | converted_995 | Is Growth factor independence 1b (GFI1B protein, human) important for Hematopoiesis? | Growth Factor Independence (Gfi) transcription factors play essential roles in Hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and Lineage specification, gfi1aa and gfi1b have distinct roles in regulating primitive and d... | yes |
Are there any functional differences between Mfd and its human Cocaine syndrome protein B (CSB) homolog? | converted_353 | Are there any functional differences between Mfd and its human Cocaine syndrome protein B (Cockayne Syndrome, Type II) homolog? | In Homo sapiens, the transcription-coupled nucleotide-excision repair coupling factor, Cockayne Syndrome, Type II, plays a critical role in restoring transcription following both UV-induced and oxidative DNA damage. It also contributes indirectly to the global repair of some forms of oxidative DNA damage. The Escherich... | yes |
Is PTEN involved in follicular thyroid carcinoma? | converted_150 | Is PTEN protein, human involved in Follicular THYROID DIAGNOSTIC RADIOPHARMACEUTICALS carcinoma? | Two of the 259 patients (0.8%), with both Follicular THYROID DIAGNOSTIC RADIOPHARMACEUTICALS carcinoma and Large head (disorder), were found to carry a germline mutation in the PTEN protein, human protein, human gene. The PTEN protein, human protein, human mutation frequency in unselected cases of Follicular THYROID DI... | yes |
Is Doxorubicin cardiotoxic? | converted_2005 | Is doxorubicin cardiotoxic? | doxorubicin (DOXO) is widely used to treat Solid Neoplasm. However, its clinical use is limited by side effects including serious Cardiotoxicity due to Myocytes, Cardiac damage. , The results provide direct evidence for the role of catalase in doxorubicin cardiotoxic responses., These results do not support the possibi... | yes |
Is Enlimomab effective for stroke treatment? | converted_2656 | Is Enlimomab effective for Cerebrovascular accident treatment? | However, this treatment failed to show benefit in the Enlimomab Acute Stroke Trial., There was no increase in the frequency of adverse events with increasing doses of enlimomab.CONCLUSIONS: Dosage of enlimomab between 140 and 480 mg administered over 5 days did not increase the risk of adverse events in patients with i... | no |
Is Niraparib effective for ovarian cancer? | converted_3561 | Is Niraparib effective for Malignant neoplasm of ovary? | Niraparib and olaparib have been approved by the US FDA for maintenance therapy after partial or complete remission in recurrent Malignant neoplasm of ovary., PURPOSE OF REVIEW: The recent United States Food and Drug Administration approvals of niraparib and olaparib as maintenance monotherapy for Platinum-Sensitive Di... | yes |
Can gene therapy restore auditory function? | converted_2789 | Can Genes therapy restore auditory function? | Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c., We demonstrate recovery of Genes and protein expression, restoration of sensory cell function, rescue of complex auditory function and recovery of hearing and balance behavior to near wild-type levels. The data represent... | yes |
Is the Fluzone intradermal and the Fluzone intradermal quadrivalent vaccine produced by different companies? | converted_3245 | Is the Fluzone intradermal and the Fluzone intradermal quadrivalent vaccine produced by different companies? | An intradermal version of Fluzone® split-virion inactivated trivalent influenza vaccine, containing 9 µg hemagglutinin per strain of A/H1N1, A/H3N2, and one B lineage virus (Fluzone Intradermal, Sanofi Pasteur), became available in the US during the 2011-2012 influenza season for adults 18-64 years of age. In advance o... | no |
Is phospholamban phosphorylated by Protein kinase A? | converted_572 | Is phospholamban phosphorylated by Protein kinase A? | cAMP-dependent protein kinase (PKA) phosphorylation of PLB1 gene, phosphorylation of PLN gene gene, at either Ser(16) by PKA , Activation of cardiac muscle Sarcoplasmic Reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB1 gene), which relieves the inh... | yes |
Are somatic mutations positioned towards the nuclear periphery? | converted_4162 | Are somatic mutations positioned towards the nuclear periphery? | lamina-associated regions, which are typically localized at the nuclear periphery, displayed higher somatic mutation frequencies than did the interlamina regions at the nuclear core., Furthermore, mutational signatures differed between the nuclear core and periphery, thus indicating differences in the patterns of DNA-d... | yes |
Is celecoxib effective for amyotrophic lateral sclerosis? | converted_3413 | Is celecoxib effective for amyotrophic lateral sclerosis? | In conclusion, the celecoxib-creatine combination was selected as preferable to the minocycline-creatine combination for further evaluation. , ESULTS: celecoxib did not slow the decline in muscle strength, vital capacity, Motor unit number estimates, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised, or aff... | no |
Is Dicer part of the RISC loading complex? | converted_856 | Is DICER1 protein, human part of the RNA-Induced Silencing Complex loading complex? | DICER1 protein, human is a component of the protein machinery (the RNA Induced Silencing Complex [RNA-Induced Silencing Complex]) which is involved in catalyzing the formation of mature microRNAs from their precursors in the process of microRNA biogenesis., RNA-induced silencing complex (RNA-Induced Silencing Complex) ... | yes |
Is clathrin involved in E-cadherin endocytosis? | converted_1045 | Is clathrin involved in CDH1 gene endocytosis? | We demonstrated that MGAT2 gene induced a stabilizing effect on CDH1 gene at the Cellular Membrane by inducing a delay in the turnover rate of the Protein Info, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent CDH1 gene endocytosis., Conversely, GnT-V... | yes |
Are there conserved noncoding elements identified between genomes of human and teleosts? | converted_506 | Are there conserved noncoding elements identified between genomes of Homo sapiens and teleosts? | We report evidence for a mechanism for the maintenance of long-range conserved synteny across Vertebrates genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target Genes, and phylogenetically and functi... | yes |
Is autophagy the process where bacteria ingest viral particles? | converted_2159 | Is autophagy the process where Bacteria ingest Viral particles? | Autophagy, a cellular degradation process, Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional Proteins and Organelles, is a cellular process associated with homeostasis., Autophagy, a programmed process in which "U" lymphocyte contents are delivered to Lysosomes for degradation, appears to ... | yes |
Is Tuberous Sclerosis a genetic disease? | converted_1594 | Is Tuberous Sclerosis a genetic Disease? | TUBEROUS SCLEROSIS 1 (disorder)-TUBEROUS SCLEROSIS 2 (disorder) complex location (TSC) is a genetic Disease, Tuberous sclerosis is a rare genetic Disease, TUBEROUS SCLEROSIS 1 (disorder)-TUBEROUS SCLEROSIS 2 (disorder) complex location (TSC) is a multisystem genetic Disease, TUBEROUS SCLEROSIS 1 (disorder)-TUBEROUS SCL... | yes |
Is vorinostat effective for glioblastoma? | converted_2486 | Is vorinostat effective for Glioblastoma Multiforme? | Conclusions: vorinostat combined with standard chemoradiation had acceptable tolerability in newly diagnosed Glioblastoma Multiforme. Although the primary efficacy endpoint was not met, vorinostat sensitivity and resistance signatures could facilitate patient selection in future trials., LESSONS LEARNED: Combination re... | no |
Is LRP1 interacting with Urokinase receptor? | converted_2833 | Is LRP1 interacting with Urokinase receptor? | Interaction with a complex formed by urokinase and its inhibitor Plasminogen Activator Inhibitor 1 induces Cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to Prolow-Density Lipoprotein Receptor-Related Protein 1., Here we investigated w... | yes |
Can Diabetes be caused by a defect in a potassium chanel? | converted_1846 | Can Diabetes be caused by a defect in a potassium chanel? | Gene Mutation in KATP Channels genes can result in hypo- or hypersecretion of Therapeutic Insulin, as in neonatal Diabetes Mellitus mellitus and Congenital Hyperinsulinism, respectively., To date, all patients affected by neonatal Diabetes Mellitus due to a Mutation Abnormality in the pore-forming subunit of the channe... | yes |
Do circRNAs remain untranslated? | converted_2156 | Do RNA, Circular remain untranslated? | We demonstrate that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression, Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins Cyclin-Dependent Kinases (also known as cell division protein kinase 2 or CDK2... | no |
Has intepirdine been evaluated in clinical trials? (November 2017) | converted_2561 | Has intepirdine been evaluated in clinical trials? (November 2017) | Using small molecules blocking 5-HT6serotonin receptor (intepirdine), inhibiting BACE activity (E2609, AZD3293, and verubecestat), or reducing uridine triacetate aggregation (TRx0237) are also currently in Phase III clinical trials.[SEP] | yes |
Is the abnormal dosage of ultraconserved elements disfavored in cancer cells? | converted_181 | Is the abnormal dosage of ultraconserved elements disfavored in Primary malignant neoplasm cells? | Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not Primary malignant neoplasm cells., We begin by showing that depletion for UCEs characterizes the most recent large-scale Homo sapiens CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis... | no |
Is Bladder training an effective method to treat urge incontinence ? | converted_705 | Is Bladder training an effective method to treat urge Incontinence ? | Mindfulness-based stress reduction appears to be a treatment worthy of further study, as in the short term, it is as effective as historical studies of Pharmacologic Substance treatment and Urinary Bladder training in reducing urge Incontinence and Incontinence-related quality of life., All patients, irrespective of th... | yes |
Should tirilazad be used for treatment of ischemic stroke? | converted_3830 | Should tirilazad be used for treatment of ischemic stroke? | CONCLUSION: Tirilazad had no effect on clinical outcome but did decrease symptomatic Vasospasm in five trials of aneurysmal SAH. , Tirilazad did not significantly decrease unfavorable clinical outcome on the Genomics Outcome Scale (odds ratio [OR] 1.04, 95% confidence interval [CI] 0.89-1.20) or Cerebral Infarction (OR... | no |
Is the length of the poly(A) tail involved in human disease? | converted_930 | Is the length of the poly(A) tail involved in human disease? | In human mitochondria, polyadenylation of RNA, Messenger, undertaken by the nuclear-encoded Mitochondrial Inheritance poly(A) RNA polymerase, is essential for maintaining Mitochondrial Inheritance gene expression. Our Molecular investigation of an autosomal-recessive spastic ataxia with Optic Atrophy, present among the... | yes |
Is the regulation of Vsr endonuclease independent of the growth phase of bacteria? | converted_1225 | Is the regulation of vsr endonuclease independent of the growth phase of bacteria? | Growth phase-dependent regulation of vsr endonuclease, vsr endonuclease levels are growth phase dependent., Growth phase-dependent regulation of vsr endonuclease may contribute to 5-Methylcytosine mutational hot spots in Escherichia coli., Using rabbit allergenic extract allergenic extract polyclonal antibodies, we hav... | no |
Is Sotrovimab effective for COVID-19? | converted_4565 | Is Sotrovimab effective for COVID-19? | It seems that Monoclonal Antibodies (e.g., low dosage bamlanivimab, baricitinib, imatinib, and sotrovimab) are a better choice for treating severe or non-severe COVID-19 patients. , The Food and Drug Administration has granted emergency use authorization to sotrovimab for the treatment of mild to moderate COVID-19 in p... | yes |
Is Tisagenlecleucel effective for B-Cell Lymphoma? | converted_2840 | Is Tisagenlecleucel effective for B-Cell Lymphoma? | The phase II JULIET trial suggests that the B-Lymphocyte Antigen B-Lymphocyte Antigen CD19, human, human-targeting actomyosin contractile ring T-cell therapy tisagenlecleucel produces durable responses in patients with relapsed and refractory diffuse large B-cell lymphoma., Tisagenlecleucel in Children and Young Adults... | yes |
Is the number of described human nuclear mutations less than 50000? | converted_2078 | Is the number of described Homo sapiens nuclear Gene Mutation less than 50000? | The number of known Gene Mutation in Homo sapiens nuclear Genes, underlying or associated with Homo sapiens inherited disease, has now exceeded 100,000 in more than 3700 different Genes (Human Gene Mutation Database)., The Human Gene Mutation Database (HGMD®) is a comprehensive collection of germline Gene Mutation in n... | no |
Are there negative enhancers? | converted_3718 | Are there negative enhancers? | Role of a YY-1 factor-binding negative Enhancer of transcription, Gene Mutation targeted to the CArG-like motif abolished the suppressive effect of the negative Enhancer of transcription and the inducibility of the Promoter during myogenic differentiation, Our results suggest that the activity of the negative Enhancer ... | yes |
Does prolactinoma increase osteoporosis risk? | converted_2496 | Does prolactinoma increase osteoporosis risk? | Prolactinoma: A Massive Effect on Bone Mineral Density in a Young Patient., Encounter due to family history of osteoporosis has been noted to be an issue in postmenopausal women with prolactinomas. This case shows a similar impact on bone health in a young male resulting in low bone mineral density for age based on Z-s... | yes |
is intense physical activity associated with longevity ? | converted_296 | is intense physical activity associated with longevity ? | We found a very significant increase in average longevity (17%) of the cyclists when compared with the general population. The age at which 50% of the general population died was 73.5 vs. 81.5 years in Tour de France participants. Our major finding is that repeated very intense exercise prolongs life span in well train... | yes |
Are super enhancers structurally insulated in chromatin loops? | converted_3854 | Are super enhancers structurally insulated in chromatin location loops? | Dissecting super-enhancer hierarchy based on chromatin location location interactions, Genetic ablation of hub enhancers results in profound defects in gene activation and local chromatin location location landscape., We also demonstrate that the Wap super-enhancer, which is built on STAT5 Protein Family Protein Family... | no |
Do tumour-associated macrophages have a prognostic role in gliomas? | converted_3238 | Do tumour-associated macrophages have a prognostic role in Glioma? | Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in Glioma using automated quantitative double immunofluorescence., This is the first study to use automated quant... | yes |
Do the proteins Talin and Amot interact? | converted_4609 | Do the proteins TLN1 gene and AMOT gene interact? | we show that AMOT gene binds TLN1 gene and is essential for relaying forces between FN1 gene and the Microtubules associated with cytoplasmic filaments[SEP] | yes |
Does nintedanib hold promise for lung disease associated with systemic sclerosis? | converted_3480 | Does nintedanib hold promise for lung disease associated with Systemic Scleroderma? | The patient developed progressive lung Fibrosis under several immunosuppressants and was started on nintedanib, with clinical and functional stabilization. Nintedanib is a tyrosine-kinase PPP1R1A gene that blocks several profibrotic pathways, inhibiting proliferation and migration of Specimen Source Codes - Fibroblasts... | yes |
Is creatinine assessment included in the MELD score? | converted_2509 | Is creatine/creatinine assessment included in the MELD score? | Model For End-Stage Hepatobiliary Disorder (MELD) scores were calculated as 3.78×ln[TB] + 11.2×ln[Integrated Neuromusculoskeletal Release] + 9.57×ln[creatine/creatine/creatinine] + 6.43. , A corrected creatine/creatine/creatinine was derived from the mGFR after application of the ResponseLevel - modification of Diet in... | yes |
Is overproduction of transthyretin is associated with amyloidosis associated neuropathy? | converted_2410 | Is overproduction of transthyretin is associated with Primary amyloidosis associated Neuropathy? | Prealbumin-associated familial Serum Serum amyloid A protein A protein polyneuropathy (TTR protein, human protein, human-FAP) is a Disease caused by the deposit of abnormal transthyretin on Body tissue, mainly Nerve, transthyretin familial Serum Serum amyloid A protein A protein polyneuropathy, We report a new transthy... | yes |
Does neuroglobin has neuroprotective properties in the setting of traumatic brain injury? | converted_1570 | Does neuroglobin has neuroprotective properties in the setting of Traumatic Brain Injury? | NGB gene has shown rich neuroprotective effects against cerebral Hypoxia, CTCAE, and therefore has the potential to impact outcomes after Traumatic Brain Injury (TBI). , NGB gene (GTPBP4 gene) is proposed to be a Neurons-specific, Hypoxia, CTCAE-responsive, neuroprotective protein. , CONCLUSION: The increased expressio... | yes |
Does the Mcm2-Ctf4-Polα axis play a role in transfer of histones to leading strand DNA at the replication forks? | converted_3572 | Does the Mcm2-WDHD1 gene-Polα axis play a role in transfer of histones to leading strand DNA at the replication forks? | The Mcm2-WDHD1 gene-Polα Cervus axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands., Although essential for epigenetic inheritance, the transfer of parental Histone antigen (H3-H4)2 tetramers that contain epigenetic modifications to replicating DNA strands is poorly understood. Here, we show that the M... | no |
Is indicated the use of antioxidant supplements in patients at risk for coronary artery disease? | converted_815 | Is indicated the use of antioxidant supplements in patients at risk for coronary artery disease? | We and others have published observational epidemiologic studies in support of VITAMINS [VA Class] in the primary prevention of CVD, but the results from intervention studies are mixed., For Vitamin E Drug Class, observational data suggest benefit at doses of 100 to 400 IU/d. Results from recent large-scale trials are ... | no |
Can venlafaxine block NET and SERT? | converted_475 | Can venlafaxine block SLC6A2 protein, Homo sapiens and Selective External Radiation Therapy? | Treatment for 14 days with 70 mg/kg per day venlafaxine, which inhibits both the SLC6A2 protein, Homo sapiens and Selective External Radiation Therapy, or 10 mg/kg per day phenelzine, a Monoamine Oxidase Inhibitor [EPC], produced antidepressant-like effects on behavior without altering SLC6A2 protein, Homo sapiens or S... | yes |
Is STAT3 transcription factor regulated by mTORC1? | converted_1691 | Is STAT3 protein, human transcription factor regulated by mechanistic target of rapamycin complex 1? | Mechanistically, mechanistic target of rapamycin complex 1 mediated IL-6-induced Stat3 activation in intestinal Epithelial Cells to stimulate the expression of downstream targets essential for cell proliferation and tissue regeneration. Therefore, mechanistic target of rapamycin complex 1 signaling critically protects ... | yes |
Are Drosophila ultraconserved elements candidate ncRNAs? | converted_1134 | Are Drosophila <basidiomycetes> ultraconserved elements candidate ncRNAs? | Highly constrained intergenic Drosophila <basidiomycetes> <basidiomycetes> ultraconserved elements are candidate ncRNAs., Here, we report the discovery and characterization of UCEs from 12 sequenced Drosophila <basidiomycetes> <basidiomycetes> species. We identified 98 elements ≥80 bp long with very high Conservation a... | yes |
Has the gorilla genome been determined? | converted_2071 | Has the Gorilla <Western Gorilla> genome been determined? | Starting with Homo sapiens, Pan Genus, Gorilla <Western Gorilla>, and orangutan Genome, our software generated an exhaustive data set of 292 ALs (∼1 kb each) in ∼3 h. , We generated a high-quality assembly of the Gorilla <Western Gorilla> genome using single-molecule, real-time sequence technology and a string graph de... | yes |
Is HDAC1 required for GATA-1 transcriptional activity? | converted_4634 | Is HDAC1 gene required for GATA1 wt Allele transcriptional activity? | HDAC1 gene gene is required for GATA1 wt Allele transcription activity, global chromatin occupancy and hematopoiesis., GATA-12RA knock-in (KI) mice suffer mild Genus Anemia and THROMBOCYTOPENIA 2 (disorder) with accumulation of immature Specimen Source Codes - Erythrocytes and Megakaryocytes in bone marrow and Abdomen>... | yes |
Can canagliflozin cause euglycemic diabetic ketoacidosis? | converted_2476 | Can canagliflozin cause euglycemic diabetic Ketoacidosis? | CASE REPORT: We present a case of a 57-year-old Human, Female adult with DIABETES MELLITUS, NONINSULIN-DEPENDENT, 1 (disorder) taking a combination of canagliflozin and metformin who presented with progressive altered mental status over the previous 2 days. Her work-up demonstrated a Metabolic acidosis with an anion ga... | yes |
Is Alpers disease inherited in an autosomal recessive mode? | converted_511 | Is Alpers Syndrome (disorder) inherited in an Autosomal recessive inheritance mode? | Alpers-Huttenlocher syndrome (AHS) is a very rare Autosomal Recessive Disorder, Alpers syndrome is an Autosomal recessive inheritance mitochondrial DNA depletion disorder that affects children and young adults, Alpers' syndrome is a fatal neurogenetic disorder first described more than 70 years ago. It is an Autosomal ... | yes |
Is the Paramyxovirus geneome segmented, negative-sense RNA? | converted_3832 | Is the Paramyxovirus geneome segmented, negative-sense RNA? | The Paramyxovirus, NOS family has a Genome - anatomical entity consisting of a single strand of negative sense RNA, The avian Paramyxovirus, NOS type 1 (APMV-1), or Newcastle disease virus (NDV), comprise a diverse group of Virus with a single-stranded, negative-sense RNA Genome - anatomical entity., Members of the Par... | no |
Is dasatinib effective for treatment of glioblastoma? | converted_2282 | Is dasatinib effective for treatment of Glioblastoma Multiforme? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 Cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
Are the proteins Erbin (LAP2) and Merlin cooperating? | converted_1559 | Are the proteins ERBB2 Interacting Protein, Human (LAP2) and Neurofibromin 2 cooperating? | ERBB2 Interacting Protein, Human and the NF2 tumor suppressor Neurofibromin 2 cooperatively regulate cell-type-specific activation of PAK2 gene gene by Recombinant Transforming Growth Factor-Beta., The results show that the epithelial-enriched protein ERBB2 Interacting Protein, Human controls the function of the NF2 tu... | yes |
Is Li–Fraumeni syndrome a rare, autosomal recessive, hereditary disorder that predisposes carriers to cancer development? | converted_3269 | Is Li–Fraumeni syndrome a rare, Autosome recessive, hereditary disorder that predisposes carriers to Primary malignant neoplasm development? | LI-FRAUMENI SYNDROME 1 (Li-Fraumeni Syndrome) is a rare Primary malignant neoplasm predisposition syndrome inherited in an Autosomal dominant multiple pterygium syndrome fashion that involves a Germline Mutation Abnormality of tumor protein 53 (TP53 wt Allele wt Allele). , LI-FRAUMENI SYNDROME 1 (Li-Fraumeni Syndrome),... | no |
Is nivolumab used for treatment of Non–Small-Cell Lung Cancer? | converted_882 | Is nivolumab used for treatment of Non–Small-Cell Lung Cancer? | BACKGROUND: Patients with advanced squamous-cell non-small-cell Primary malignant neoplasm of lung (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a full... | yes |
Can CMB305 be used against sarcomas? | converted_3434 | Can CMB305 be used against sarcomas? | CMB305 induces CTAG1A wt Allele specific T-Lymphocyte responses in both Supernumerary mandibular right first primary molar and Medical Research Council patients and these patients had excellent overall survival (OS) outcomes in the initial phase I study., Data suggesting this Vaccine [APC] may improve OS for Supernumer... | yes |
Are enhancers directional in their targeting of gene promoters? | converted_4168 | Are enhancers directional in their targeting of gene Promoter? | Novel bi-directional duplex Promoter (BDDP) were constructed by placing two identical core Promoter divergently on both upstream and downstream sides of their duplicated Enhancer Elements, Genetic., These Promoter initiate transcription in opposite directions and are separated only by a short enhancer region, which is ... | no |
Is cabozantinib effective for Hepatocellular Carcinoma? | converted_3031 | Is cabozantinib effective for Liver carcinoma? | However, clinical trials of nonselective kinase inhibitors with c-Met activity (Tivantinib, cabozantinib, Foretinib, and golvatinib) in patients with altretamine/cisplatin/cyclophosphamide protocol have failed so far to demonstrate significant efficacy. , Rationale for use, clinical trial data, and current recommendati... | yes |
Αre plants from the genus Strychnos the original source of curare? | converted_4277 | Αre Plants from the genus Strychnos the original source of Curare? | Poisons are widespread in Plants and animal allergen extracts and humankind has often tried to turn them to its own advantage. Owing to their poisonous properties, some species of Strychnos genus have been employed mainly in hunting and fishing, as an adjunct to weapons used not only in the search of Food allergenic ex... | yes |
Can vitamin B1 deficiency cause encephalopathy? | converted_478 | Can thiamine deficiency cause Encephalopathies? | Wernicke's Encephalopathies (WE) is a severe neurological syndrome caused by Thiamine Drug Class (Thiamine Drug Class) deficiency and clinically characterized by the sudden onset of mental status changes, Ocular abnormalities, and Cerebellar Ataxia, Wernicke-Korsakoff Syndrome (or Wernicke-Korsakoff Encephalopathies) i... | yes |
Does hypofractionated radiotherapy offers any benefit for DIPG? | converted_4053 | Does hypofractionated radiotherapy offers any benefit for Diffuse Intrinsic Pontine Glioma? | CONCLUSION: Hypofractionated RT for children with newly diagnosed Diffuse Intrinsic Pontine Glioma is well tolerated and feasible from the viewpoint of reducing a patient's burden of treatment. Re-irradiation at first progression is suggested to be beneficial., Median OS and time to progression were similar between con... | no |
Is transcription of eRNA bidirectional? | converted_2667 | Is transcription of eRNA bidirectional? | In addition to widespread transcription of long non-coding RNA (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thus referred to as Enhancer of transcription RNA (eRNAs)., Kallikrein (KLK3), which codes for kallikrein-related peptidase 3, human (Prostate-Specific Antigen), is a w... | yes |
Is Ameloblastoma (AB) a common benign tumor occurring in the brain? | converted_4667 | Is Ameloblastoma (AB) a common benign Specimen Source Codes - tumor occurring in the brain? | Ameloblastoma is a benign odontogenic Specimen Source Codes - Specimen Source Codes - tumor which undergoes malignant transformation to ameloblastic carcinoma. , Ameloblastomas are Benign Neoplasm that most commonly affecting the Head>Mandible. , Ameloblastoma is a Neoplasms arising in the craniofacial skeleton., Amelo... | no |
Has the protein GFP been used in transgenesis for live protein imaging? | converted_1237 | Has the protein GFP been used in transgenesis for live protein imaging? | we review recent advancement in the functional studies of the three different GnRH neuron systems, mainly focusing on the electrophysiological analysis of the GnRH-Green Fluorescent Proteins (GFP) Animals, Transgenic., founders were found to be transgenic for GFP., GFP expression was detected in a wide range of Mus tis... | yes |
Do nematodes contain architectural proteins like CTCF? | converted_3761 | Do nematodes contain architectural proteins like CTGF protein, human? | A mode of genetic regulation that involves insulators and insulator binding proteins to establish independent transcriptional units is currently not known in nematodes including Caenorhabditis elegans. , the insulator protein CTGF protein, human has been secondarily lost in derived nematodes like Caenorhabditis elegans... | no |
Is STAT3 involved in EIF2AK2-dependent suppression of autophagy? | converted_963 | Is STAT3 protein, human involved in EIF2AK2 gene-dependent suppression of autophagy? | STAT3 protein, human protein, human may act as a competitive PPP1R1A gene of EIF2AK2 gene gene. Indeed, pharmacological or genetic inhibition of STAT3 protein, human protein, human stimulates EIF2AK2 gene gene-dependent Eukaryotic Translation Initiation Factor 2 Subunit 1 phosphorylation and autophagy. Conversely, the ... | yes |
Is farnesoid X receptor (FXR) a nuclear receptor? | converted_1013 | Is farnesoid X receptor (NR1H4 wt Allele) a Receptors, Nuclear? | NR1H4 gene (NR1H4 wt Allele) belongs to the ligand-activated Receptors, Nuclear superfamily, and functions as a TRANSCRIPTION FACTOR regulating the transcription of numerous Genes involved in Bile Acid [EPC] homeostasis, lipoprotein and glucose metabolism, NR1H4 gene (NR1H4 wt Allele) is an ascending target for metabo... | yes |
Can telomere length shortening be reversed by telomerase? | converted_1952 | Can telomere length shortening be reversed by Telomerase? | Telomere length is regulated around an equilibrium set point. telomere shorten during replication and are lengthened by Telomerase. Disruption of the length equilibrium leads to Disease; thus, it is important to understand the mechanisms that regulate length at the Molecular level. , High Telomerase activity is detecte... | yes |
Is there a dependence between chromatin organization and dorsoventral gene expression in Drosophila? | converted_4428 | Is there a dependence between chromatin organization and dorsoventral gene expression in Drosophila <basidiomycetes>? | Independence of chromatin conformation and gene regulation during Drosophila <basidiomycetes> <basidiomycetes> dorsoventral patterning., Here, using the dorsoventral patterning of the Drosophila <basidiomycetes> <basidiomycetes> melanogaster embryo as a model system, we provide evidence for the independence of chromati... | no |
Is Alu hypomethylation associated with breast cancer? | converted_24 | Is Alu hypomethylation associated with Malignant neoplasm of Breast? | Alu and Long Interspersed Nucleotide Element-1 hypomethylation is associated with ERBB2 wt Allele enriched subtype of Malignant neoplasm of Breast, In IBC, Alu hypomethylation correlated with negative Estrogen Receptors (Endoplasmic Reticulum) status, In survival analyses, low Alu methylation status tended to be associ... | yes |
Is nucleosome eviction ATP-dependent? | converted_308 | Is nucleosome location eviction ATP-dependent? | ATP-dependent chromatin location location remodeling and nucleosome location location-depleted 'barriers' co-operate to determine the kinetics of nucleosome location location organization, ATP-dependent nucleosome location location-remodeling factors endow chromatin location location with structural flexibility by prom... | yes |
Is the protein ABCG2 (ATP-Binding Cassette, subfamily G, member 2, transporter) excreting uric acid? | converted_3475 | Is the protein ABCG2 wt Allele (ATP-Binding Cassette, subfamily G, member 2, transporter) excreting uric acid? | TP-binding cassette transporter, sub-family G, member 2 (ABCG2 wt Allele wt Allele/BCRP) is a well-studied urate transporter expressed on apical membranes in several Body tissue, including the Intestines, Abdomen>Liver, and Both kidneys., the discovery that ABCG2 wt Allele wt Allele plays a central role on extra-renal ... | yes |
Is SATB1 expressed in thymocytes? | converted_3649 | Is DNA-Binding Protein SATB1 expressed in thymocyte? | A thymocyte factor DNA-Binding Protein DNA-Binding Protein SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter Genes., DNA-Binding Protein DNA-Binding Protein SATB1 is a Homeodomain Proteins and is predominantly expressed in thymocyte. , DNA-Binding Protein DNA-Binding Protein S... | yes |
Has AZD9668 been tested in clinical trials? | converted_4075 | Has AZD9668 been tested in clinical trials? | Efficacy, safety and tolerability of AZD9668 (5, 20 and 60 mg bid) were compared with placebo in a randomised, double-blind, placebo-controlled, 12-week, Phase IIb trial (NCT00949975: approved by an Investigational Review Board), in patients with symptomatic COPD receiving maintenance tiotropium. , A randomised, placeb... | yes |
Is lithium effective for treatment of amyotrophic lateral sclerosis? | converted_2902 | Is Lithium antipsychotics effective for treatment of Amyotrophic Lateral Sclerosis? | In terms of Disease-modifying treatment options, several drugs such as Dexpramipexole, pioglitazone, Lithium antipsychotics, and many others have been tested in large multicenter trials, albeit with disappointing results., Despite several positive case reports and short studies, further controlled researches have faile... | no |
Is Crohn's disease (CD) linked to the consumption of refrigerated food? | converted_1396 | Is Crohn's disease (CD) linked to the consumption of refrigerated Food allergenic extracts? | Environmental risk factors playing a causative role in Crohn's disease of oral soft tissues (CD) remain largely unknown. Recently, it has been suggested that refrigerated Food allergenic extracts could be involved in disease development., This study supports the opinion that CD is associated with exposure to domestic r... | yes |
Is phospholipid hydroperoxide glutathione peroxidase a selenoprotein? | converted_2846 | Is phospholipids hydroperoxide glutathione peroxidase a Selenoproteins? | GLUTATHIONE PEROXIDASE (GPX1 gene) is the major Selenoproteins in most Body tissue in animal allergen extracts., The selenoenzyme GPX4 gene is essential for early embryogenesis and cell viability for its unique function to prevent phospholipids oxidation., the major Selenoproteins expressed by Germ Cells in the Testis,... | yes |
Has the proteome of mice hippocampus been analysed? | converted_2407 | Has the proteome of CASP14 gene hippocampus been analysed? | We employed a discovery-based proteomic approach in subcellular fractions of Hippocampus (Brain) tissue from chronic intermittent alcohol (CIE)-exposed C57Bl/6J CASP14 gene to gain insight into alcohol-induced changes in GluN2B signaling complexes. , We employed shotgun liquid chromatography-mass spectrometry (LC-MS) ... | yes |
Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | converted_1408 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (Polymorphic catecholergic ventricular tachycardia) cause Sudden Cardiac Death? | Here we refine our approach, and apply it to novel Variant found in 2266 patients across two large cohorts with inherited Sudden death syndromes, namely catecholaminergic Polymorphism Ventricular Tachycardia by ECG Finding (Polymorphic catecholergic Ventricular Tachycardia by ECG Finding) or Brugada Syndrome (disorder)... | yes |
Is co-loss of BRCA2-RB1 associated with better prognosis for prostate cancer patients? | converted_3965 | Is co-loss of BRCA2 gene-RB1 associated with better prognosis for Malignant neoplasm of prostate patients? | In Homo sapiens Malignant neoplasm of prostate cell lines (LNCaP and LAPC4), loss of BRCA2 gene gene leads to the castration-resistant phenotype. Co-loss of BRCA2 gene gene-RB1 in Homo sapiens Malignant neoplasm of prostate cells induces an epithelial-to-mesenchymal transition, which is associated with invasiveness and... | no |
Does PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | converted_2229 | Does PCSK9 protein, Homo sapiens (Proprotein Convertase 2 subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | Recently it was revealed that the secreted Proprotein Convertase Subtilisin Kexin 9 (PCSK9 protein, Homo sapiens protein, Homo sapiens) binds with Low-Density Lipoproteins-receptor (Low-Density Lipoproteins-R) causing its degradation in the Lysosomes with the result of Low-Density Lipoproteins-C accumulating in the blo... | no |
Does MVIIA and MVIIC bind to the same calcium channel? | converted_1434 | Does MVIIA and MVIIC bind to the same calcium channel? | We examined the post-pubertal behavioral effects of neonatal (postnatal day 7) medial prefrontal Adrenal Cortex Diseases infusion of either vehicle or N-type and P/Q-type presynaptic voltage-dependent calcium channel blockers (ziconotide and MVIIC respectively; 6.8 and 45 pmol infused respectively) in Rattus norvegicus... | no |
Do DNA double-strand breaks play a causal role in carcinogenesis? | converted_1130 | Do DNA double-strand breaks play a causal role in carcinogenesis? | The DNA non-homologous end-joining repair gene XRCC6/Ku70 plays an important role in the repair of DNA double-strand breaks (DSBs) induced by both exogenous and endogenous DNA-damaging agents. Defects in overall 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione repair capacity can lead to genomic instability and... | yes |
Are Copy Number Variants (CNVs) depleted in regions of low mappability? | converted_2955 | Are Copy Number Variants (CNVs) depleted in regions of low mappability? | Homo sapiens copy number Variant are enriched in regions of low mappability., Applying PopSV to 640 human genomes, we find that low-mappability regions are approximately 5 times more likely to harbor germline CNVs, in stark contrast to the nearly uniform distribution observed for somatic CNVs in 95 cancer genomes. In a... | no |
Have germline variants been associated to colorectal cancer? | converted_1501 | Have Germline Variant been associated to Malignant neoplasm of colon and/or rectum? | Overall, we identified aberrant RNA Transcript in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder cdE cdE haplotype finding finding and a 83-b... | yes |
Do chromatin features predict genes associated with eQTLs? | converted_2349 | Do chromatin features predict Genes associated with eQTLs? | Using the random forest classifier, we found that genomic proximity plus five Male-to-Female Transsexual, Self-Report and chromatin features are able to predict>90% of target Genes within 1 megabase of eQTLs, Using the random forest classifier, we found that genomic proximity plus five Male-to-Female Transsexual, Self-... | yes |
Is there evidence for de novo genesis of enhancers in vertebrates? | converted_1278 | Is there evidence for de novo genesis of enhancers in Vertebrates? | De novo genesis of enhancers in Vertebrates., Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation of enhan... | yes |
Is Tcf3 associated with the Wnt pathway? | converted_3803 | Is Tcf3 associated with the Wnt pathway? | TCF3, a novel positive regulator of osteogenesis, plays a crucial role in MIR17 wt Allele modulating the diverse effect of canonical Wnt signaling in different microenvironments, Furthermore, the role of MIR17 wt Allele was because of its target gene TCF3 (TRANSCRIPTION FACTOR), a key transcription factor of canonical ... | yes |
Is there an association between serum interleukin-6 concentrations and outcomes of stroke patients? | converted_1176 | Is there an association between serum Recombinant Interleukin-6 concentrations and outcomes of stroke patients? | In addition, IL-6 concentrations affect clinical outcomes in ischemic stroke., After appropriate adjustment, the odds ratios for the association of markers and poor outcome (comparing the upper and the lower third) were Recombinant Interleukin-6, 3.1 (95% CI: 1.9-5.0); C-reactive protein, 1.9 (95% CI: 1.2-3.1); Fibrin... | yes |
Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | converted_218 | Has ergocalciferol has been shown to reduce incidence of falls in older people in clinical trials? | However, apart from the beneficial effects of 800 IU/d of cholecalciferol for reduction of falls in the elderly, causality remains yet unproven in randomized controlled trials (RCTs). , The rate of falls and the number of fallers was significantly reduced in two studies evaluating the effect of medication on preventing... | yes |
Is proton beam therapy used for treatment of craniopharyngioma? | converted_4359 | Is proton beam therapy used for treatment of Craniopharyngioma? | The majority of children had adjuvant therapy comprising proton beam therapy (18/59; 30.5%) or conventional radiotherapy (16/59; 27.1%)., Proton Therapy for Craniopharyngioma - An Early Report from a Single European Centre., AIMS: Proton beam therapy (Mast/Stem Cell Growth Factor Receptor Kit, human) is being increasi... | yes |
Can cffDNA be used for non-invasive testing? | converted_1427 | Can cffDNA be used for non-invasive testing? | Non-invasive prenatal testing using cell-free Prenatal care DNA in maternal circulation, The identification of cell-free Prenatal care DNA (cffDNA) in maternal circulation has made non-invasive prenatal testing (NIPT) possible., In recent years, technical advances in the molecular analysis of Prenatal care DNA (e.g., d... | yes |
Does ziconotide bind to N-type calcium channels? | converted_520 | Does ziconotide bind to N-type CALCIUM SUPPLEMENTS channels? | Since this Geographic Locations partially overlaps with residues previously implicated in block of the channel by omega-Conotoxin GVIA, we assessed the effects of Gene Mutation in the putative EF hand domain on channel block by omega-Conotoxin GVIA and the structurally related omega-conotoxin MVIIA. Both of the toxins ... | yes |
Are there any anti-amyloid antibody approved as drug for Alzheimer's disease treatment? | converted_3186 | Are there any anti-amyloid antibody approved as Pharmacologic Substance for ALZHEIMER DISEASE, FAMILIAL, 1 treatment? | Treatment with memantine, a noncompetitive NMDA receptor Substance with receptor Substance with receptor antagonist mechanism of action (substance) mechanism of action (substance) which is an approved Pharmacologic Substance for treatment of ALZHEIMER DISEASE, FAMILIAL, 1, rescued protein phosphatase-2A activity by dec... | no |
Is there an upper limit on the functional fraction of the human genome? | converted_4040 | Is there an upper limit on the functional fraction of the human genome? | Mutational load considerations lead to the conclusion that the functional fraction within the human genome cannot exceed 25%, and is probably considerably lower.[SEP] | yes |
Is there any algorithm for enhancer identification from chromatin state? | converted_68 | Is there any algorithm for Enhancer of transcription identification from chromatin state? | RFECS: a random-forest based algorithm for Enhancer of transcription identification from chromatin state., However, only a limited number of cell types or chromatin marks have previously been investigated for this purpose, leaving the question unanswered whether there exists an optimal set of Histone antigen modificati... | yes |
Thymoquinone is ineffective against radiation induced enteritis, yes or no? | converted_3674 | Thymoquinone is ineffective against radiation induced enteritis, yes or no? | n this study, we found that thymoquinone (TQ) could mitigate Intestines damages induced by irradiation. , In this study, we found that thymoquinone (TQ) could mitigate Intestines damages induced by irradiation., In this study, we found that thymoquinone (TQ) could mitigate Intestines damages induced by irradiation., TQ... | no |
Is patisiran currently (November 2017) in clinical phase II trials? | converted_2421 | Is patisiran currently (November 2017) in clinical phase II trials? | This review addresses nine small-interfering RNAs (siRNAs) and one unique MicroRNAs (miRNA) inhibitor, which entered the phase 2-3 clinical trials. The siRNAs in focus are PF-04523655, TKM-080301, Atu027, SYL040012, SYL1001, siG12D-LODER (phase 2), QPI-1002, QPI-1007, and patisiran (phase 3). , patisiran (phase 3), P... | no |
Can Diazepam be beneficial in the treatment of traumatic brain injury? | converted_3008 | Can Diazepam be beneficial in the treatment of traumatic brain injury? | he present experiment examined the effects of diazepam, a positive modulator at the GABA-A Receptor, on survival and cognitive performance in traumatically brain-injured animal allergen extracts. I[SEP] | yes |
Do all archaea possess multiple origins of DNA replication? | converted_1325 | Do all Archaea possess multiple origins of DNA replication? | Origins differ in number and structure across the three domains of life and their properties determine the dynamics of chromosome replication. Bacteria and some Archaea replicate from single origins, whereas most Archaea and all Eukaryota replicate using multiple origins., Replication starts at a single Ori site in bac... | no |
Is pesticide exposure associated with polyneuropathy? | converted_386 | Is pesticide exposure associated with polyneuropathy? | As the syndrome occurred after the acute Cholinergic Agents syndrome but before Phosphoric Acid Esters-induced delayed polyneuropathy, the syndrome was called 'intermediate syndrome'., The characteristic features of the IMS are weakness of the Muscle Tissue of respiration (Vaginal contraceptive Vaginal contraceptive di... | yes |
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