id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 19.2k | label stringclasses 2
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converted_362 | Is there a package in R/bioconductor for classification of alternative splicing? | spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data., Recent software improvements in full-length transcript deconvolution prompted us to develop spliceR, an R package for classification of alternative splicing and prediction of coding potential., splice... | yes |
converted_3561 | Is Niraparib effective for ovarian cancer? | Niraparib and olaparib have been approved by the US FDA for maintenance therapy after partial or complete remission in recurrent ovarian cancer., PURPOSE OF REVIEW: The recent United States Food and Drug Administration approvals of niraparib and olaparib as maintenance monotherapy for platinum-sensitive, high-grade ova... | yes |
converted_1396 | Is Crohn's disease (CD) linked to the consumption of refrigerated food? | Environmental risk factors playing a causative role in Crohn's Disease (CD) remain largely unknown. Recently, it has been suggested that refrigerated food could be involved in disease development., This study supports the opinion that CD is associated with exposure to domestic refrigeration, among other household facto... | yes |
converted_2141 | Is osteocrin expressed exclusively in the bone? | Evolution of Osteocrin as an activity-regulated factor in the primate brain., Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons., Osteocrin (Ostn) is a recentl... | no |
converted_4392 | Are TAMs good anticancer therapeutic targets? | Integrating therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results in preclinical trials and warrants further investigation to determine its translational benefit in human cancer patients.[SEP] | yes |
converted_2275 | Is Drk essential for anesthesia-resistant memory (ARM) in Drosophila? | Anesthesia-resistant memory (ARM) was described decades ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memory inDrosophilaremain poorly understood. Whether the several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in one or more ... | yes |
converted_2266 | Are neurexins localized at pre-synapses? | Neurexins and neuroligins are two distinct families of single-pass transmembrane proteins localized at pre- and postsynapses, respectively. , presynaptic neurexins, best-characterized transsynaptic interactions are formed by presynaptic neurexins, which bind to diverse postsynaptic ligands., presynaptic neurexin[SEP] | yes |
converted_516 | Is there an association between TERT promoter mutation and survival of glioma patients? | Mutations lead to TERT upregulation and are associated with aggressive clinical behavior in glioblastomas., Kaplan-Meier's survival analysis showed that TERT promoter mutation (P=0.037), Isocitrate dehydrogenase (IDH) mutation (P<0.001), and 1p/19q codeletion (P<0.001) were associated with favorable overall survival (O... | yes |
converted_2430 | Are splicing speckles associated with transcription? | We show here that RNA splicing speckled domains (splicing speckles) fluctuate in constrained nuclear volumes and remodel their shapes., We present a model where recycling splicing factors return as part of small sub-speckles from distal sites of RNA processing to larger splicing speckles by a directed ATP-driven mechan... | no |
converted_4162 | Are somatic mutations positioned towards the nuclear periphery? | lamina-associated regions, which are typically localized at the nuclear periphery, displayed higher somatic mutation frequencies than did the interlamina regions at the nuclear core., Furthermore, mutational signatures differed between the nuclear core and periphery, thus indicating differences in the patterns of DNA-d... | yes |
converted_1182 | Is macroautophagy a selective degradation process? | Selective autophagy, Macroautophagy (autophagy) is a bulk degradation system for cytoplasmic components and is ubiquitously found in eukaryotic cells, Here we show that selective autophagy downregulates Ty1 transposition, We propose that selective autophagy safeguards genome integrity against excessive insertional muta... | yes |
converted_436 | Is progesterone effective for treatment of patients with traumatic brain injury based on clinical trial data? | BACKGROUND: Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. , The proportion of patients with a favorable outcome on the Glasgow Outcome Scale (good recovery or moderate disability) wa... | no |
converted_727 | Is the optogenetics tool ChR2 light-sensitive? | Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology., Light-sensitive genes chiefly including the genetically targeted light-gated channels channelrhodopsin-2 (C... | yes |
converted_3373 | Is the drug Exubera currently (March 2020) available? | Despite discontinuation of the first inhalable insulin, Exubera®, due to suboptimal market acceptance, development of orally inhaled insulin delivery systems has been galvanized by the recent approval of Afrezza® and several others awaiting approval.[SEP] | no |
converted_1992 | Is there a role of proton beam therapy in medulloblastoma treatment? | All papers directly compared outcomes from protons with photons, five papers included medulloblastoma, four papers each included craniopharyngioma and low grade gliomas and three papers included ependymoma., There are many indications of protontherapy for paediatric brain tumours in curative intent, either for localize... | yes |
converted_4502 | Is autism thought to be related to the Arginine Vasopressin Peptide (AVP)? | However, we recently found that cerebrospinal fluid (CSF) concentration of the "social" neuropeptide arginine vasopressin (AVP) is significantly lower in pediatric ASD cases vs. controls., A large number of controlled trials demonstrated that exogenous oxytocin or arginine-vasopressin administration can mitigate social... | yes |
converted_2522 | Does Uc.160 promote cancer? | We previously discovered the downregulation of T-UCR expression in gastric cancer (GC), indicating that T-UCRs could play an important role in GC biology. Uc.160+, a T-UCR reported to be downregulated in human cancer, has not been examined in GC.METHODS: We analyzed the expression pattern of Uc.160+ in nonneoplastic an... | no |
converted_2868 | Is pazopanib an effective treatment of glioblastoma? | RESULTS: The six-month progression-free survival (PFS) rates in phase II (n = 41) were 0% and 15% in the PTEN/EGFRvIII-positive and PTEN/EGFRvIII-negative cohorts, respectively, leading to early termination. , Single-agent pazopanib did not prolong PFS in this patient population but showed in situ biological activity a... | no |
converted_3572 | Does the Mcm2-Ctf4-Polα axis play a role in transfer of histones to leading strand DNA at the replication forks? | The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands., Although essential for epigenetic inheritance, the transfer of parental histone (H3-H4)2 tetramers that contain epigenetic modifications to replicating DNA strands is poorly understood. Here, we show that the Mcm2-Ctf4-Polα axis fa... | no |
converted_480 | Are epigenetic modifications implicated in cardiovascular development and disease? | Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored., The study of epigenetic markers is, therefore, a very promising frontier of scienc... | yes |
converted_227 | Can DNA intercalators function as topoisomerase inhibitors? | The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding a... | yes |
converted_712 | Is PER3 required for CHK2 activation in human cells? | Per3, a circadian gene, is required for Chk2 activation in human cells., Depletion of Per3 by siRNA almost completely abolished activation of checkpoint kinase 2 (Chk2) after inducing DNA damage in human cells., Per3 overexpression induced Chk2 activation in the absence of exogenous DNA damage,, Per3 overexpression als... | yes |
converted_187 | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target, We further found that ATO t... | yes |
converted_3457 | Is Rad4/XPC a DNA damage sensing protein? | Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex., Kinetic gating mechanism of DNA damage recognition by Rad4/XPC., These findings indicate that the lesions recognized by Rad4/XPC thermodynamically destabilize the Watson-Crick double helix in a manner that facilitates t... | yes |
converted_4699 | Are there roles for cohesin mutations in AML? | Several landmark studies have shown that cohesin mutations perturb the balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPC). Emerging data now begin to uncover the molecular mechanisms that underpin this phenotype. Among these mechanisms is a role for cohesin in the control... | yes |
converted_1354 | Has the presence of delayed enhancement been documented in athletes performing strenuous exercise? | Atypical findings such as marked cardiac dilation, reduced deformation, or small patches of delayed gadolinium enhancement may be commonly encountered in well-trained athletes, but, at present, the prognostic significance of such findings is unknown. , On CMR, DGE localized to the interventricular septum was identified... | yes |
converted_3237 | Is the crystal structure of Pim-1 available? | Recent crystallographic studies of Pim-1 have identified unique structural features but have not provided insight into how the kinase recognizes its target substrates. , a co-crystal structure of lead molecule (HS38) in complex with DAPK3, a dual Pim/DAPK3 inhibitor (HS56), The crystal structure of this compound with P... | yes |
converted_3475 | Is the protein ABCG2 (ATP-Binding Cassette, subfamily G, member 2, transporter) excreting uric acid? | TP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a well-studied urate transporter expressed on apical membranes in several tissues, including the intestine, liver, and kidney., the discovery that ABCG2 plays a central role on extra-renal uric acid excretion,[SEP] | yes |
converted_3408 | Is cathepsin L active in endosomes? | Cathepsin L in the Late Endosome/Lysosome, endosomal cathepsin L, Immunofluorescence and immunoblotting investigations revealed the presence of cathepsin L in the nuclear compartment in addition to its expected endo-lysosomal localization in colorectal carcinoma cells., cleavage by the endosomal/lysosomal protease cath... | yes |
converted_3753 | Is Bcl-2-like protein 1 an pro apoptotic protein? | Extensively established key effectors of such apoptotic bypass mechanisms, the antiapoptotic BCL-2 (apoptosis regulator BCL-2) proteins, determine the response of cancer cells to chemotherapeutics, decreasing the expression of anti-apoptotic factors, including apoptosis regulator Bcl-2 and Bcl-2-like protein 1 in FaDu ... | no |
converted_4055 | Is progeria caused by an autosomal recessive gene? | Hutchinson-Gilford progeria syndrome (HGPS) is an autosomal-dominant genetic disease that leads to accelerated aging and often premature death caused by cardiovascular complications. , Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric segmental premature aging disease., Progeria is sp... | yes |
converted_2975 | Is dupilumab effective for treatment of asthma? | The appropriate use of these biologics, and of those in development (e.g., benralizumab and dupilumab), should be aided by further understanding of asthma phenotypes and endotypes, utilizing appropriate biomarkers., Simultaneous targeting of both IL-4 and IL-13 by blocking IL-4 receptor α using dupilumab has yielded mo... | yes |
converted_4210 | Is the zelda transcription factor a chromatin remodeller? | ncreasing the number of Zelda binding sites accelerates the kinetics of nuclei transcriptional activation regardless of their transcriptional past, Zelda facilitates transcriptional activation by accumulating in microenvironments where it could accelerate the duration of multiple pre-initiation steps., Zelda acts throu... | yes |
converted_3486 | Are there lncRNAs that control the extent of neuronal outgrowth? | Regulation of Neuroregeneration by Long Noncoding RNAs., Here, we profiled gene expression following sciatic nerve crush in mice and identified long noncoding RNAs (lncRNAs) that act in the regenerating neurons and which are typically not expressed in other contexts. We show that two of these lncRNAs regulate the exten... | yes |
converted_2286 | Does a tonsillectomy affect the patient's voice? | Group B had a better awareness of tooth damage (78% vs 30% of patients, P ≤ .001), voice change (61 vs 19%, P = .005), and burns to lips and mouth (44% vs 8%, P = .005). Finally, 35% more patients from group B rated their understanding of tonsillectomy as good or very good (P = .017)., Some patients complaint for dry... | yes |
converted_1556 | Is CHEK2 involved in cell cycle control? | Moreover, cell-cycle progression genes [i.e. E2F transcription factor (E2F) family and histone deacetylase ( HDAC )] and DNA-repair genes [i.e. growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased., As CHEK2 is a cell-cycle master contro... | yes |
converted_2795 | Is chlorotoxin a peptide? | chlorotoxin peptide , Chlorotoxin (CTX) is a 36-amino-acid disulfide-containing peptide derived from the venom of the scorpion Leiurus quinquestriatus., The mature Odontobuthus doriae chlorotoxin peptide has a 35-amino-acid residue and four disulfide bounds. , Chlorotoxin (CTX), a disulfide-rich peptide from the scorpi... | yes |
converted_4694 | Are there any R packages that help with visualizing data on spirals? | spiralize: an R package for Visualizing Data on Spirals., Spiral layout has two major advantages for data visualization. First, it is able to visualize data with long axes, which greatly improves the resolution of visualization. Second, it is efficient for time series data to reveal periodic patterns. Here we present t... | yes |
converted_676 | Has proteomics been used in the study of Pick's disease? | In Pick's disease, increased AGE, CML, CEL, HNE and MDAL bands of about 50 kDa were observed in the frontal cortex (but not in the occipital cortex) in association with increased density of glial acidic protein bands., Thus, brain and cerebrospinal fluid (CSF) samples from patients with Alzheimer's disease, Down syndro... | yes |
converted_1974 | Does mTOR regulate the translation of MAPKAPK2? | mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype., Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show p... | yes |
converted_1655 | Are ultraconserved elements depleted among copy number variants (CNVs)? | We have demonstrated that nonexonic UCEs are depleted among segmental duplications (SDs) and copy number variants (CNVs) and proposed that their ultraconservation may reflect a mechanism of copy counting via comparison. Here, we report that nonexonic UCEs are also depleted among 10 of 11 recent genomewide data sets of ... | yes |
converted_4558 | Do mutations in KCNT2 only cause phenotypes with epilepsy? | KCNT2 variants resulting in substitutions affecting the Arg190 residue have been shown to cause epileptic encephalopathy and a recognizable facial gestalt. We report two additional individuals with intellectual disability, dysmorphic features, hypertrichosis, macrocephaly and the same de novo KCNT2 missense variants af... | no |
converted_1989 | Does CRISPR inversion of CTCF sites alter genome topology? | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function, To test the functional significance of this observation, we combined CRISPR/Cas9-based genomic-DNA-fragment editing with chromosome-conformation-capture experiments to show that the location and relative orientations of CBSs determine... | yes |
converted_4679 | Is there any role of the 'Greek islands' in olfactory receptor choice? | Chromatin conformation capture using in situ Hi-C on fluorescence-activated cell-sorted olfactory sensory neurons and their progenitors shows that olfactory receptor gene clusters from 18 chromosomes make specific and robust interchromosomal contacts that increase with differentiation of the cells. These contacts are o... | yes |
converted_933 | Are patients with marfan syndrome at increased risk of arrhythmias? | Marfan syndrome (MFS) is a variable, autosomal-dominant disorder of the connective tissue. In MFS serious ventricular arrhythmias and sudden cardiac death (SCD) can occur., Marfan's patients carry increased risk for cardiac arrhythmias. , Ventricular arrhythmias were present in 21% and were associated with increased le... | yes |
converted_673 | Does the protein mTOR regulate autophagy? | autophagy is negatively regulated by the mammalian target of rapamycin receptor (mTOR), Subjecting cells to starvation or rapamycin efficiently induces autophagy by inhibiting the MTOR signaling pathway triggering increased autophagic flux. , Several pathways, including mTOR, have been shown to regulate autophagy., the... | yes |
converted_728 | Is the Prostate- Specific Antigen (PSA) test relevant only for prostate cancer? | rostate cancer (PCa) is the most frequently diagnosed malignancy and the second leading cause of cancer death in men, PSA is known to be prostate specific, but not PCa specific, deficiencies of serum PSA as a prostate-cancer-specific diagnostic test are well recognized., medical debate surrounding the use of the prosta... | no |
converted_3363 | Is bortezomib a Proteasome inhibitor? | The proteasome-inhibitor bortezomib, The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. , Proteasome inhibitor bortezomib , The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently explored for activity in solid tumors including non-small cell ... | yes |
converted_3493 | Is there a BRCA mutation analysis in the Greek population? | Comprehensive BRCA mutation analysis in the Greek population. Experience from a single clinical diagnostic center., Germline mutations in the BRCA1 and BRCA2 genes are associated with hereditary predisposition to breast and ovarian cancer. Sensitive and accurate detection of BRCA1 and BRCA2 mutations is crucial for per... | yes |
converted_167 | Is CD84 genetically associated with arthritis? | The SNP is predicted to disrupt transcription factor binding site motifs in the 3' UTR of an immune-related gene, CD84, and the allele associated with better response to etanercept was associated with higher CD84 gene expression in peripheral blood mononuclear cells (P = 1 × 10(-11) in 228 non-RA patients and P = 0.004... | yes |
converted_3931 | Is cadherin a plasma membrane marker? | the plasma membrane-bound E-cadherin protein, VE-cadherin protein levels were also increased in the plasma membrane fraction. , recycling of VE-cadherin to the plasma membrane,, E-cadherin, a central component of the adherens junction (AJ), is a single-pass transmembrane protein [SEP] | yes |
converted_245 | Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | Gene regulation in Drosophila spermatogenesis: analysis of protein binding at the translational control element TCE., We have previously identified a 12 nucleotide long sequence element, the TCE, that was demonstrated to be necessary for translational control of expression in the male germ line of Drosophila melanogast... | yes |
converted_2616 | Is Tocilizumab effective for Giant-Cell Arteritis? | Emerging evidence for adjunctive therapy with tocilizumab, methotrexate, aspirin, angiotensin receptor blockers, and statins is encouraging and may lead to a more mainstream role for these therapies among patients with GCA., TNF-α blockers are ineffective in giant cell arteritis, while observational evidence and a pha... | yes |
converted_2844 | Does epidural anesthesia for pain management during labor affect the Apgar score of the the infant? | We retrospectively analyzed 93 consecutive single-pregnancy patients who underwent cesarean section with combined spinal-epidural anesthesia. The patients were divided into two groups, depending on the use of 6% HES 130/0.4: group A (461 ± 167 ml of saline-based HES was administered; 43 patients) and group B (HES not ... | no |
converted_4600 | Is NfL (neurofilament light chain) a biomarker of neurodegeneration? | Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). , Neurofilament light chain (NfL) is a new, non-disease specific, widely studied biomarker indicative of axonal injury and degeneration, the neurodegeneration biomarker neurofilament light chain (NfL) ,... | yes |
converted_3871 | Is Olaparib effective for prostate cancer? | We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.METHODS: We conducted a phase 2 trial in which patients with metastatic, castration-resistant prostate cancer were treated w... | yes |
converted_1768 | Is there a role of regorafenib for sarcoma treatment? | Regorafenib has been approved for third-line therapy., Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial., DISCUSSION: The design of this trial allows an assessment of regorafenib activity over placebo in... | yes |
converted_3674 | Thymoquinone is ineffective against radiation induced enteritis, yes or no? | n this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation. , In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation., In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation., TQ... | no |
converted_2637 | Is there a disease or condition called Exploding Head Syndrome? | This case report describes the first-ever diagnosis of exploding head syndrome in a patient with longstanding epilepsy and novel nocturnal events. , Exploding head syndrome (EHS) is characterized by loud noises or a sense of explosion in the head during sleep transitions., Exploding head syndrome is characterized by th... | yes |
converted_818 | Is there evidence to suggest that triiodothyronine has neuroprotective properties in traumatic brain injury? | Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury., Treatment with T3 (1.2μg/100g body weight, i.p.) 1h after TBI resulted in a significant improvement in motor and cognitive recovery after CCI, as well as in marked reduction of lesion volumes. , Western blot analysis reve... | yes |
converted_1548 | Is the gene SLC6A2 associated with orthostatic intolerance? | Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. , Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intol... | yes |
converted_4444 | Can epigenetic modifications be heritable? | Epigenetic alterations (epimutations) could thus contribute to heritable variation within populations and be subject to evolutionary processes such as natural selection and drift. [SEP] | yes |
converted_506 | Are there conserved noncoding elements identified between genomes of human and teleosts? | We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target genes, and phylogenetically and functio... | yes |
converted_1392 | Do RNA:DNA hybrids preferentially form in high or low GC regions? | Intrinsic termination signals for multisubunit bacterial RNA polymerases (RNAPs) encode a GC-rich stem-loop structure followed by a polyuridine [poly(U)] tract, and it has been proposed that steric clash of the stem-loop with the exit pore of the RNAP imposes a shearing force on the RNA in the downstream RNA:DNA hybrid... | yes |
converted_4677 | Is Ameloblastoma (AB) a benign tumor that never metastasizes? | Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart of benign epithelial odontogenic tumor of ameloblastoma (AB) by the WHO classification, AC develops pulmonary metastasis in about one third of the patients and reveals a poor prognosis, Amelo... | no |
converted_835 | Is metabolic syndrome related with cardiovascular disease? | The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). , As a molecular link between metabolic signals, i... | yes |
converted_3406 | Does xaliproden improve prognosis of amyotrophic lateral sclerosis? | Treatment for crampsThere is evidence (13 RCTs, N = 4012) that for the treatment of cramps in MND, compared to placebo:- memantine and tetrahydrocannabinol (THC) are probably ineffective (moderate-quality evidence);- vitamin E may have little or no effect (low-quality evidence); and- the effects of L-threonine, gabapen... | no |
converted_1729 | Are mutations in the STXBP1 gene associated with epilepsy? | Folinic acid responsive epilepsy in Ohtahara syndrome caused by STXBP1 mutation., A novel mutation in STXBP1 gene in a child with epileptic encephalopathy and an atypical electroclinical pattern., Mutations in STXBP1 gene, encoding the syntaxin binding protein 1, have been recently described in Ohtahara syndrome, or ea... | yes |
converted_4100 | Are synonymous sites in primates and rodents functionally constrained? | To resolve this contradiction between expectations and observations, we used processed pseudogenes as a model for strict neutral evolution, and estimated selective constraint on synonymous sites using the rate of substitution at pseudosynonymous and pseudononsynonymous sites in pseudogenes as the neutral expectation. A... | no |
converted_15 | Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer? | Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial., Our data demonstrate that Re-188-labeled Herceptin effectively inhibited the growth of DU145 cells compared to the Herceptin- and Re-188-treated cohorts. This implies... | yes |
converted_356 | Is the yeast Μac1 transcription factor induced upon copper deficiency? | Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces cerevisiae., The copper-depletion induced CTR2 transcription can be abrogated by genetic deletion of copper-sensing transcription factor Mac1p, Taken together, our results suggest that Mac1p can activate the ... | yes |
converted_172 | Is cytisine superior to nicotine replacement therapy for smoking cessation? | The effectiveness of cytisine for continuous abstinence was superior to that of nicotine-replacement therapy at 1 week, 2 months, and 6 months. In a prespecified subgroup analysis of the primary outcome, cytisine was superior to nicotine-replacement therapy among women and noninferior among men., CONCLUSIONS: When comb... | yes |
converted_967 | Are CTCF and BORIS involved in genome regulation and cancer? | CTCF is ubiquitously expressed and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal interactions, nuclear compartmentalisation, and alternative splicing. CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in cancer. The ... | yes |
converted_4439 | Are circular RNAs implicated in diseases of the eye? | n this review, we summarized the function of circRNAs and indicated their roles in the pathogenesis of DR, which may provide new therapeutic targets for clinical treatment., This study aimed to determine whether circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for proliferative d... | yes |
converted_888 | Does replication timing affect the rate of somatic mutations? | Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome, ll classes of substitutions are affected, suggesting a generalized mechanism involving replication time-dependent DNA damage, We show... | yes |
converted_552 | Is zyxin a focal adhesion protein? | zyxin from FAs, zyxin relocation from focal adhesions , . Here we systematically examined the expression, localization, and function of zyxin, a focal adhesion protein, focal adhesion protein zyxin, Focal adhesions formed in the absence of α-actinins are delayed in their maturation, exhibit altered morphology, have de... | yes |
converted_3482 | Is PF-05190457 an inverse agonist of the ghrelin receptor? | Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects., To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults., PF-05190457 is a well-tolerated first-in-cl... | yes |
converted_688 | Is Ctf4 involved in sister chromatid cohesion establishment? | In addition to Eco1, several other factors contribute to cohesion establishment, including Ctf4, Ctf18, Tof1, Csm3, Chl1 and Mrc1, but little is known about their roles. Here, we show that each of these factors facilitates cohesin acetylation. Moreover, the absence of Ctf4 and Chl1, but not of the other factors, causes... | yes |
converted_2618 | Can non ubiquitinated Tomm20 promote mitophagy? | A total of 338 new targets were identified and from these we validated glycogen synthase kinase 3β (Gsk3β), which can phosphorylate α-synuclein, and translocase of outer mitochondrial membrane 20 (Tomm20), a mitochondrial translocase that, when ubiquitinated, promotes mitophagy, as SCFFbxo7substrates both in vitro and... | no |
converted_2797 | Is selenocysteine an aminoacid? | Selenocysteine (Sec), a rare genetically encoded amino acid with unusual chemical properties, is of great interest for protein engineering., Selenocysteine (SeC) is a naturally available Se-containing amino acid that displays splendid anticancer activities against several human tumors. [SEP] | yes |
converted_4604 | Is Daprodustat effective for anemia? | CONCLUSIONS: Oral daprodustat was noninferior to CERA in achieving and maintaining target hemoglobin levels in Japanese ND patients. , BACKGROUND: The Anemia Studies in chronic kidney disease (CKD): Erythropoiesis via a Novel prolyl hydroxylase inhibitor (PHI) Daprodustat-Dialysis (ASCEND-D) trial will test the hypothe... | yes |
converted_4226 | Is phosphoenolpyruvate carboxykinase 1 (PCK1) the rate-limiting enzyme in gluconeogenesis? | Phosphoenolpyruvate carboxykinase (PEPCK) is a metabolic enzyme in the gluconeogenesis pathway,, PEPCK, a key enzyme involved in gluconeogenesis associated with a decrease in the expression of master genes involved in the VLDL synthesis , Transcriptome analysis of rate-limiting enzymes involved in hepatic gluconeogenes... | yes |
converted_2316 | Can the CEP290 gene mutations be targeted by AAV-mediated gene therapy? | The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy.[SEP] | no |
converted_4296 | Is FKBP52 encoding a chaperone ? | Hsp90 co-chaperones Pp5 and FKBPs, The co-chaperone FK506-binding protein 51 (FKBP51), co‑chaperone FKBP52 [SEP] | yes |
converted_1335 | Is there increased incidence of incontinence in athletes? | Urinary incontinence affects women of all ages, including top female athletes, but is often under-reported. The highest prevalence of urinary incontinence is reported in those participating in high impact sports., The prevalence of female stress urinary incontinence is high, and young adults are also affected, includin... | yes |
converted_1145 | Could RG7112 be used as cancer therapy? | RG7112 is a potent and selective member of the nutlin family of MDM2 antagonists currently in phase I clinical studies., Our findings offer a preclinical proof-of-concept that RG7112 is effective in treatment of solid tumors expressing wild-type p53., On the other hand, JNJ-26854165, a novel tryptamine derivative and R... | yes |
converted_1272 | Is curcumin a phytochemical? | we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals, The phytochemical, curcumin, has been reported to play many beneficial roles., Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chemopreventive p... | yes |
converted_2848 | Is inositol effective for trichotillomania? | Patients assigned to inositol failed to show significantly greater reductions on primary or secondary outcomes measures compared with placebo (all P>0.05)., This is the first study assessing the efficacy of inositol in the treatment of trichotillomania, but found no differences in symptom reductions between inositol an... | no |
converted_2009 | Can Pentraxin 3 predict outcomes of sepsis? | As compared with low serum PTX3and sTWEAK cases, cirrhotic patients with high serum PTX3/sTWEAK levels a have higher probability of new severe infections, severe sepsis, septic shock, type 1 hepatorenal syndrome, in-hospital, and 3-month follow-up mortalities. , Neonates with high nPTX3 concentrations also have lowered... | yes |
converted_4177 | Should cerebrolysin be used for aneurysmal subarachnoid hemorrhage? | No significant difference was detected in the proportion of patients with favorable six-month GOSE in either study group (odds ratio (OR): 1.49; 95% confidence interval (CI): 0.43-5.17). Secondary functional outcome measures for favorable six-month recovery i.e. a mRS of 0 to 3 (OR: 3.45; 95% CI 0.79-15.01) were compar... | no |
converted_345 | Are circRNAs associated with diseases and traits? | Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits., Circular RNAs play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. Their interaction with disease associated miRNAs indicates that circular RNAs are... | yes |
converted_711 | Do proton pump inhibitors affect thyroxine absorption? | Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption, Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfe... | yes |
converted_3834 | Does the use of bDMARDs during pregnancy impact neonatal development? | Exposure to bDMARDs during pregnancy does not seem to interfere with post-natal development up to infancy., Long-term follow-up data about newborns exposed to bDMARDs during pregnancy are however scarce. [SEP] | no |
converted_4514 | Do angiotensin-converting-enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) increase the likelihood of severe COVID-19? | These findings suggest that the use of ACE-I and ARB is not associated with adverse outcomes and may be associated with improved outcomes in COVID-19, which is immediately relevant to care of the many patients on these medications., There are theoretical concerns that angiotensin-converting enzyme inhibitors (ACEIs) an... | no |
converted_1965 | Is butterfly rash a symptom of Systemic lupus erythematosus? | Diagnosing SLE can be challenging because of the myriad of clinical features and substantial variability between patients. Cutaneous involvement is present in about 60% of cases and typically manifests as a malar or butterfly rash., The prevalence of systemic lupus erythematosus (SLE) is 28 per 100,000. , We report a 1... | yes |
converted_502 | Is Mycobacterium avium less susceptible to antibiotics than Mycobacterium tuberculosis? | The prevalence of MAC lung infection in two inner city hospitals was four times higher than that of TB., Most patients with combined infection were clinically consistent with MTB and responded to anti MTB treatment alone., The triplex PCR developed by us could be used to detect and differentiate M. tuberculosis, M. avi... | yes |
converted_1129 | Is Wnt16b secreted in response to chemotherapy? | In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation., In a recent article in Nature Medicine, Sun et al. show that increased expression of Wnt family member wingless-type ... | yes |
converted_2630 | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis., Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expr... | yes |
converted_1959 | Are Ultra-conserved elements (UCEs) enriched in segmental duplications? | Here we address the process by which CNVs become depleted of UCEs., We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are significantly depleted for UCEs., In strikin... | no |
converted_1177 | Could bioprinting be used in regenerative medicine against bone disease? | Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. , It is expecte... | yes |
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