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Can methylenetetrahydrofolate reductase (MTHFR) gene mutations cause homocystinuria? | converted_2090 | Can methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase (NADPH)) Gene Mutation cause Homocystinuria? | Methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase (NADPH)) deficiency is a rare Autosomal Recessive Disorder. , Several mutations seen in methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase (NADPH)) give rise to the formation of Hyperhomocysteinemia and Homocystinuria, a cons... | yes |
Is Wnt16b secreted in response to chemotherapy? | converted_1129 | Is Wnt16b secreted in response to chemotherapy? | In this study, we found WNT16B could be expressed and secreted into the microenvironment by Homo sapiens ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation., In a recent article in Nature Medicine, Sun et al. show that increased expression of Wnt family member wingles... | yes |
There is no drug available to prevent HIV infection, Pre-exposure prophylaxis (PrEP), yes or no? | converted_2965 | There is no drug available to prevent Human immunodeficiency virus II infection, Pre-exposure prophylaxis (HIV: PrEP and PEP), yes or no? | pre-exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London - analysis of pharmacokinetics, safety and outcomes., The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (tenofovir dis... | no |
Has the protein TIEG1 been associated with apoptosis? | converted_147 | Has the protein TIEG1 been associated with apoptosis? | Recombinant Transforming Growth Factor-Beta) inducible early gene 1 (TIEG1) is known to induce apoptosis in Recombinant Transforming Growth Factor-Beta sensitive pancreatic Tumor Cells, malignant, yet its effect on Recombinant Transforming Growth Factor-Beta resistant Tumor Cells, malignant remains unclear, overexpress... | yes |
Have the promoter regions of the genes implicated in Rett Syndrome been characterized with CAGE? | converted_1899 | Have the promoter regions of the genes implicated in MECP2 protein, Homo sapiens gene been characterized with CAGE? | CAGE-defined promoter regions of the genes implicated in MECP2 protein, Homo sapiens protein, Homo sapiens Genes., Gene Mutation in three functionally diverse genes cause MECP2 protein, Homo sapiens protein, Homo sapiens Genes. Although the functions of FOXG1 Genes (FOXG1), Methyl-CpG-Binding Protein 2 (MECP2 protein, ... | yes |
Does smoking increase risk for glioblastoma? | converted_1125 | Does Location characteristic ID - Smoking increase risk for glioblastoma? | Glioma risk has consistently been inversely associated with allergy history but not with Location characteristic ID - Smoking history despite putative biologic plausibility., No relation was observed between Glioma risk and Location characteristic ID - Smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P ... | no |
Has istadefylline been considered as a treatment for Parkinson's disease? | converted_3602 | Has istadefylline been considered as a treatment for Parkinson Disease? | istradefylline (Urethral intrinsic sphincter deficiency) is a new Pharmacologic Substance developed for the treatment of Parkinson Disease (Lugano Lymphoma Response Classification Progressive Disease by PET). It is an adenosine receptor A2A antagonists that will represent an important option for patients with advanced ... | yes |
Should minocycline be used for mild Alzheimer disease? | converted_3984 | Should minocycline be used for mild Alzheimer disease? | Conclusions and Relevance: minocycline did not delay the progress of cognitive or functional impairment in people with mild cytarabine/daunorubicin protocol during a 2-year period. [SEP]Relations: minocycline has relations: drug_effect with Arthritis, drug_effect with Arthritis, contraindication with kidney disease, co... | no |
Are there clinical trials on stem cells in multiple sclerosis | converted_1057 | Are there clinical trials on stem Cells in Multiple Sclerosis | Cells are generally given intravenously. Multiple sclerosis, Rheumatoid Arthritis and Discoid Discoid lupus erythematosus erythematosus have been successfully treated in Homo sapiens clinical trials, Human multipotent mesenchymal stem cell (selenomethylselenocysteine) therapies are currently being tested in clinical tr... | yes |
Is amantadine effective for treatment of disorders conciousness? | converted_129 | Is amantadine effective for treatment of disorders conciousness? | We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from Apraxia, oculomotor, Cogan type. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, lea... | yes |
Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | converted_108 | Are Stress Granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | Shprintzen-Goldberg syndrome have been linked to several pathologies including inflammatory diseases, Primary malignant neoplasm, Virus Diseases, and Neurodegenerative Disorders such as AMYOTROPHIC LATERAL SCLEROSIS 1 (ALS) and frontotemporal dementia (Frontotemporal dementia)., Like several other ALS-associated Protei... | yes |
Is muscle lim protein (MLP) involved in cardiomyopathies? | converted_828 | Is Muscle Tissue lim Protein Info (MARCKSL1 gene) involved in cardiomyopathies? | Muscle LIM Protein Info (MARCKSL1 gene) has been proposed to be a central player in the pathogenesis of Cardiomyopathies. In line with this notion, the homozygous loss of MARCKSL1 gene results in Cardiac - anatomy qualifier hypertrophy and Cardiomyopathy, Dilated. Moreover, MARCKSL1 gene is induced in several models of... | yes |
Can multiple myeloma patients develop hyperviscosity syndrome? | converted_2451 | Can Multiple Myeloma patients develop Hyperviscosity syndrome? | Multiple myeloma (millimeter) is an immedicable malignancy of the human plasma cells producing abnormal Antibodies, in vitro diagnostic (also referred to as Paraproteins) leading to kidney problems and Hyperviscosity syndrome. , This skin condition may be observed in patients with the following condtions, such as prima... | yes |
Is Loss of function one of the cardinal signs of inflammation? | converted_2390 | Is Loss of function one of the cardinal signs of Inflammation? | The concept of the four cardinal signs of acute Inflammation comes from antiquity as Redness et tumor cum calore et dolore, (Erythema and Swelling with heat and Pain:-:Point in time:^Patient:-) extended later by functio laesa (loss of function)., As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Cels... | yes |
Does the Oncotype DX test work with paraffin embedded tissues? | converted_1713 | Does the Oncotype DX Breast Cancer Assay test work with paraffin embedded tissues? | The Oncotype-DX Breast Cancer Assay (Genomic Health, Redwood City, CA) quantifies gene expression for 21 Genes in Malignant neoplasm of breast tissue by performing reverse transcription polymerase chain reaction (RT-PCR) on formalin-fixed paraffin-embedded (FFPE) tumour blocks that are obtained during initial surgery (... | yes |
Does Yersinia pestis causes a respiratory infection? | converted_2040 | Does Yersinia pestis causes a respiratory Communicable Diseases? | Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing Pneumonia, Yersinia pestis causes the fatal Respiratory Tract Diseases pneumonic plague., Pulmonary Communicable Diseases by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fat... | yes |
Is there any research that relates the function of Notch Signaling with Alzheimer Disease? | converted_1491 | Is there any research that relates the function of Notch Signaling with Alzheimer Disease? | RALBP1 gene regulates signaling pathways by abrogating or releasing signaling molecules. Since the discovery, already >15 years ago, of its catalytic component, Presenilin-1, and even much earlier with the identification of Amyloid beta-Protein Precursor as its first substrate, γ-secretase has been commonly associated ... | yes |
Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | converted_1883 | Is there any tool that facilitates the functional analysis of cis-regulatory regions in Zebrafish? | Zebrafish Enhancer of transcription detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in Zebrafish., he cis-regulatory sequences control when, where, and how much Genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. ... | yes |
Does TRIM37 gene mutation causes Mulibrey nanism? | converted_1595 | Does TRIM37 Protein Info, Homo sapiens gene Mutation Abnormality causes Mulibrey nanism? | OBJECTIVE: We studied pubertal development and fecundity in males with Mulibrey nanism (TRIM37 Protein Info, Homo sapiens wt Allele) caused by Gene Mutation in the TRIM37 Protein Info, Homo sapiens Protein Info, Homo sapiens gene., In TRIM37 Protein Info, Homo sapiens wt Allele, Gene Mutation in TRIM37 Protein Info, Ho... | yes |
Is FKBP52 encoding a chaperone ? | converted_4296 | Is tacrolimus binding protein 4 encoding a chaperone ? | HSP90AA1 wt Allele co-chaperones tissue-factor-pathway inhibitor 2 and FKBPs, The co-chaperone FK506-binding protein 51 (FKBP5 wt Allele), co‑chaperone tacrolimus binding protein 4 [SEP]Relations: tau protein binding has relations: molfunc_protein with FKBP4, molfunc_protein with FKBP4, molfunc_protein with PRKAA1, mol... | yes |
Is subacute sclerosing panencephalitis caused by the Measles vaccine? | converted_2562 | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | Subacute Sclerosing Panencephalitis (SSPE) is a potentially fatal complication of measles. , Subacute Sclerosing Panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk f, Subacute Sclerosing Panencephalitis should be eliminated by measles vaccination, T... | no |
Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer? | converted_15 | Is the monoclonal immunoglobulin complex location trastuzumab (Herceptin) of potential use in the treatment of Malignant neoplasm of Pelvis>Prostate? | Herceptin is widely used in treating Her2-overexpressing Breast cancer. However, the application of Herceptin in Malignant neoplasm of Pelvis>Prostate is still controversial., Our data demonstrate that Re-188-labeled Herceptin effectively inhibited the growth of DU145 cells compared to the Herceptin- and Re-188-treated... | yes |
Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | converted_2721 | Is Brucella species abortus the organism that causes brucillosis known to cause spontaneous Abortions:Number:Point in time:^Patient:Quantitative:Reported in Homo sapiens? | . Brucellosis is a major cause of Fever of unknown origin (Pyrexia of unknown origin (excl puerperal)), Brucellosis is the most common Bacterial Zoonoses, and causes a considerable burden of Disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to Communicable Diseases with Brucell... | no |
Is Rucaparib effective for ovarian cancer? | converted_2602 | Is rucaparib effective for ovarian cancer? | INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and Loss of Heterozygosity high Platinum-Sensitive Disease ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type Loss of Heterozygosity low carcinomas., High Loss of Heterozygosity is associated... | yes |
Does a tonsillectomy affect the patient's voice? | converted_2286 | Does a tonsillectomy affect the patient's TelecommunicationCapabilities <voice>? | Group B had a better awareness of tooth damage (78% vs 30% of patients, P ≤ .001), TelecommunicationCapabilities <TelecommunicationCapabilities <voice>> change (61 vs 19%, P = .005), and Burn injury to Lip structure and mouth (44% vs 8%, P = .005). Finally, 35% more patients from group B rated their understanding of t... | yes |
Has ZP-PTH been tested in a phase II clinical trial? | converted_3387 | Has ZP-PTH been tested in a phase II clinical trial? | This system was successfully tested in a Phase 2 clinical trial for the treatment of post-menopausal women with Encounter due to family history of Encounter due to family history of osteoporosis.[SEP]Relations: stenosis or atrophy of the coronary ostium has relations: disease_disease with abnormal origin or aberrant co... | yes |
Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | converted_1105 | Are Thyroid Hormones receptor alpha1 mutations implicated in Thyroid Hormones resistance syndrome? | Gene Mutation in Homo sapiens TRα1 mediate RTH with features of Hypothyroidism in particular Body tissue (e.g. skeleton, Multisection:Find:Pt:Abdomen+Pelvis>Gastrointestinal tract:Doc:US), but are not associated with a markedly dysregulated pituitary-thyroid axis., Clinical phenotype of a new type of Thyroid Hormones r... | yes |
Is Fanconi anemia presented as a genetically and clinically heterogeneous disease entity? | converted_1274 | Is Fanconi Genus Anemia presented as a genetically and clinically heterogeneous Disease entity? | Fanconi Anemia (doxorubicin/fluorouracil protocol) is a rare, Autosomal recessive inheritance, genetically complex, DNA repair deficiency syndrome in man. Patients with doxorubicin/fluorouracil protocol exhibit a heterogeneous spectrum of clinical features. The most significant and consistent phenotypic characteristics... | yes |
Is pazopanib an effective treatment of glioblastoma? | converted_2868 | Is pazopanib an effective treatment of glioblastoma? | RESULTS: The six-month progression-free survival (PFS) rates in phase II (n = 41) were 0% and 15% in the PTEN/EGFRvIII-positive and PTEN/EGFRvIII-negative cohorts, respectively, leading to early termination. , Single-agent pazopanib did not prolong PFS in this patient population but showed in situ biological activity a... | no |
Are long non coding RNAs as conserved in sequence as protein coding genes? | converted_63 | Are long non coding RNAs as conserved in sequence as protein coding genes? | Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally., hey are under stronger selective pressure than neutrally evolving sequences-particularly in their Promoter Regions, Genetic, which display levels of selec... | no |
Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | converted_1223 | Is there any association of the chromosomal region harboring the gene ITIH3 gene with SCHIZOPHRENIA 2 (disorder)? | The most widely shared subset of genes-common to five of six disorders-included ANK3 gene gene, AS3MT gene gene, CACNA1C gene gene, CACNB2 gene gene, CNNM2 gene gene, CSMD1 protein, human protein, human, MUCL3 gene, ITIH3 gene gene, NT5C2 gene gene, PPP1R11 gene gene, SYNE1 gene gene, TCF7L2 protein, human, TENM4 gene ... | yes |
Is there a role for TET proteins in invariant natural killer T cells (iNKT) cell fate? | converted_3670 | Is there a role for TET proteins in invariant natural killer T cells (iNKT) cell fate? | TET proteins regulate the lineage specification and transcription-coupled nucleotide-excision repair-mediated expansion of Invariant Natural Killer T-Cells., We found that simultaneous Gene Deletion Abnormality of Probable Methylcytosine Dioxygenase TET2 and Methylcytosine Dioxygenase TET3 in Mus sp. CD4+CD8+ double-po... | yes |
Does replication timing affect the rate of somatic mutations? | converted_888 | Does replication timing affect the rate of somatic Gene Mutation? | Here we observe that Mutation Abnormality rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human Genome - anatomical entity, ll classes of substitutions are affected, suggesting a generalized mechanism involving replication ti... | yes |
Is g-H2AX a marker for double strand breaks? | converted_3610 | Is g-H2AX a marker for double strand breaks? | The specific phosphorylation of histone H2AX on serine residue 139, described as γ-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs). , expression of the DNA double-strand break marker gamma-H2AX (γH2AX) , pH2AX, a marker of the DNA double-strand break (DSB)[SEP]Relations: Serine has relation... | yes |
Is intraoperative radiotherapy used for treatment of glioblastoma? | converted_2166 | Is intraoperative radiotherapy used for treatment of glioblastoma? | 1) Intraoperative radiotherapy ( indolepyruvate ferredoxin oxidoreductase activity , 1,000-2,000 rad) was applied in 13 cases; the 2-year survival was 41.6%. , The median survival time after IORT was 12 months for 9 patients with glioblastoma or Anaplastic astrocytoma, while it was 51 months for 8 patients with less i... | no |
Can sorafenib activate AMPK? | converted_328 | Can sorafenib activate AMP-Activated Protein Kinases? | Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMP-Activated Protein Kinases), in a manner that involves either upstream LKB1 or CAMKK2 gene gene. , Persistent activation of AMP-Activated Protein Kinases by sorafenib finally led to the impairment of glucose metabolism both in MCF-7 and SKB... | yes |
Are there interactomes available for POU5F1 and SOX2? | converted_1226 | Are there interactomes available for POU5F1 protein, human and SOX2 protein, human? | The interactomes of POU5F1 protein, human protein, human and SOX2 protein, human protein, human enhancers in human embryonic stem cells., We assayed long-range chromosomal interactions on putative enhancers of POU5F1 protein, human protein, human and SOX2 protein, human protein, human Genes in human embryonic stem cell... | yes |
Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | converted_364 | Is alemtuzumab effective for remission induction in patients diagnosed with T-Cell Prolymphocytic Leukemia? | Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-Cell Prolymphocytic Leukemia, A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its combination with the curre... | yes |
Tocilizumab is an anti-TNF antibody, yes or no? | converted_3168 | tocilizumab is an anti-Recombinant Tumor Necrosis Factor Family Protein antibody, yes or no? | was treated with tocilizumab, an anti-Interleukin 6 Receptor Monoclonal Antibody [EPC] , tocilizumab (TCZ) is a humanized Monoclonal Antibody [EPC] against Recombinant Interleukin-6 receptor licensed in 2009 that has demonstrated clinical efficacy in various adult Rheumatoid Arthritis populations. Rheumatoid Arthritis ... | no |
Does atemoya juice inhibit the CYP1A2 enzyme? | converted_4587 | Does atemoya juice inhibit the CYP1A2 enzyme? | Atemoya juice significantly inhibited CYP1A2 activity in Homo sapiens liver microsomes, but not the activities of Cytochrome p450 Cytochrome p450 CYP2C9 enzyme enzyme and cytochrome P450 3A., This suggests that the intake of an excess amount of atemoya juice is necessary to cause a change in the pharmacokinetics of phe... | yes |
Is retinol binding protein 4 an adipokine? | converted_4686 | Is retinol binding protein 4 an Adipokines? | Systematic Quantification of Neurotrophic Adipokines RBP4 protein, human protein, human, SERPINF1 wt Allele, Homo sapiens, and CLU gene in Homo sapiens Cerebrospinal Fluid and Serum., Retinol-binding protein 4 (RBP4 protein, human protein, human) is a prominent Adipokines i, alpha-2-HS-Glycoprotein and Retinol Binding ... | yes |
Has protein citrullination been implicated in rheumatoid arthritis? | converted_944 | Has protein citrullination been implicated in Rheumatoid Arthritis? | : Citrullination has become a hot topic within recent years due to its involvement in diseases such as Rheumatoid Arthritis (RA), Multiple Sclerosis and Fibrosis. , Current literature suggests that increased levels of citrullinated Proteins are found in several if not all inflammatory diseases. , Antibodies, in vitro d... | yes |
Are BBS mutations involved in syndromic Hirschsprung disease? | converted_525 | Are Bardet-Biedl Syndrome Gene Mutation involved in syndromic Hirschsprung disease? | Epistasis between ret unit of radiation dose and Bardet-Biedl Syndrome Gene Mutation modulates enteric innervation and causes syndromic Hirschsprung disease, Here, we report 3 families with Bardet-Biedl Syndrome and HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1 with concomitant Gene Mutation in Bardet-Biedl Syndrome genes... | yes |
Is aggrephagy a variant of autophagy? | converted_3813 | Is aggrephagy a variant of autophagy? | The selective branch of autophagy that deals with identification, capture and degradation of Protein Info aggregates is called aggrephagy., Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded Protein Info aggregates, , , it is largely unknown how misfolded polypeptides form aggr... | yes |
Is there an upper limit on the functional fraction of the human genome? | converted_4040 | Is there an upper limit on the functional fraction of the human genome? | Mutational load considerations lead to the conclusion that the functional fraction within the human genome cannot exceed 25%, and is probably considerably lower.[SEP] | yes |
Can mogamulizumab be used for the treatment of cutaneous T-cell lymphoma? | converted_3027 | Can mogamulizumab be used for the treatment of Lymphoma, T-Cell, Cutaneous? | In the large international phase III MAVORIC trial, patients with previously treated Lymphoma, T-Cell, Cutaneous who received the anti-CCR4 monoclonal antibody mogamulizumab experienced significantly longer progression-free survival and higher response rates, as well as better quality of life, than those who received v... | yes |
Are microRNA (miR) regulated through DNA methylation of their promoters? | converted_1369 | Are MicroRNAs (miR) regulated through DNA methylation of their promoters? | We found that TCF7L1 gene down-regulation in the context of constitutively active Wnt signaling does not result from Promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (histone H3 trimethyl Lys4 ... | yes |
Have studies shown that there is no link between DNA methylation patterns and Post Traumatic Stress Disorder? | converted_2130 | Have studies shown that there is no link between DNA methylation patterns and Post Traumatic Stress Disorder? | Using pre-deployment SKA2 gene gene methylation levels and childhood Wounds and Injuries exposure, we found that the previously published suicide prediction rule significantly predicted post-deployment PTSD symptoms (AUC=0.66, 95% CI: 0.53-0.79) with an optimal sensitivity of 0.81 and specificity of 0.91. Permutation a... | no |
Are the members of the KRAB-ZNF gene family promoting gene repression? | converted_3471 | Are the members of the KRAB-ZNF Genes family promoting Genes repression? | The Proteins encoded by these genes, whose expression is often tissue-specific, act as epigenetic suppressors contributing to the addition of repressive chromatin marks and DNA methylation., Here, using a reporter system, we show that TRIM28/KRAB-ZNFs alter DNA methylation patterns in addition to Histone H3 Trimethyl ... | yes |
Are astronauts in higher risk for developing cancer? | converted_3557 | Are astronauts in higher risk for developing cancer? | Understanding space radiation health effects is critical due to potential increased morbidity and mortality following spaceflight. , No significant associations between space radiation dose and mortality were found using logistic regression with an internal reference group, adjusting for medical radiation., Despite ye... | no |
Are cyclophilins proteins that bind to prolines? | converted_297 | Are cyclophilins Proteins that bind to prolines? | Cyclophilins are ubiquitously expressed Proteins that bind to prolines and can catalyse CISH protein, human/trans isomerization of proline residues., a characteristic of the cyclophilin family of Proteins that bind prolines and often act as CISH protein, human-trans peptidyl-prolyl isomerases. , The cyclophilins are wi... | yes |
Have yeast prions become important models for the study of the basic mechanisms underlying human amyloid diseases? | converted_2973 | Have Saccharomyces cerevisiae Prions become important models for the study of the basic mechanisms underlying human Serum amyloid A protein diseases? | Endogenous Saccharomyces cerevisiae amyloids that control heritable traits and are frequently used as models for human Serum Serum amyloid A protein A protein diseases are termed Saccharomyces cerevisiae Prions, Fibrous cross-β aggregates (amyloids) and their transmissible forms (Prions) cause diseases in Mammals (incl... | yes |
Is RUNX1T1 associate with obesity? | converted_4243 | Is RUNX1T1 associate with BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20? | RUNX1T1 rs34269950 is associated with BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20 and Metabolic Syndrome X., Of these Single Nucleotide Polymorphism only rs34269950 located in the 'RRACH' motif, the most common N-methyladenosine (METTL3 gene) methylation modification site (recognized by FTO protein, human protein, huma... | yes |
Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | converted_159 | Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth Disease? | Charcot-Marie-Tooth Disease, Type 2D (CMT2D) is an autosomal-dominant axonal peripheral Neuropathy characterized by impaired motor and sensory function in the distal extremities. Gene Mutation in the glycyl-tRNA synthetase (GARS) gene cause CMT2D, Dominant mutations in GARS cause rare forms of Charcot-Marie-Tooth Disea... | yes |
Is Cabotegravir effective for HIV prevention? | converted_4240 | Is Cabotegravir effective for HIV Infections prevention? | A new paradigm for antiretroviral delivery: long-acting cabotegravir and rilpivirine for the treatment and prevention of HIV Infections Infections., PURPOSE OF REVIEW: Cabotegravir (Carbonic Anhydrase 1 (enzyme), Human) and rilpivirine (RPV) is the first long-acting injectable antiretroviral therapy (ART) option approv... | yes |
Is Hirschsprung disease one of the characteristics of the Mowat-Wilson syndrome? | converted_747 | Is Hirschsprung disease one of the characteristics of the Mowat-Wilson syndrome? | Mowat-Wilson syndrome is a genetic disease caused by heterozygous Gene Mutation or Gene Deletion of the zinc finger E-box-binding homeobox 2 (ZEB2 gene gene) gene. The syndrome is characterized by typical Facial features, moderate-to-severe mental retardation, Epilepsy and variable Congenital Abnormality, including Hir... | yes |
Is there a role for CADM1 in Myelodysplastic syndrome (MDS)? | converted_4413 | Is there a role for CADM1 gene in Myelodysplastic syndrome (MDS)? | Together with the frequent simultaneous Gene Deletion of MLL protein, human, ammonium tetrathiomolybdate and Cytophaga-like bacteria and Gene Mutation of Putative Polycomb Group Protein Putative Polycomb Group Protein ASXL1, Splicing Factor 3B Subunit 1, human and Cytophaga-like bacteria, we show that CADM1 gene gene m... | no |
Has silicon been used in treatment of incontinence ? | converted_1447 | Has silicon been used in treatment of incontinence ? | an artificial anal sphincter. Worldwide, there are two established devices on the market: the artificial bowel sphincter® (CONSTRICTING BANDS, CONGENITAL) from A. M. S. (Minnetonka, MNSs Blood-Group System, USA) and the soft anal band® from A. M. I. (Feldkirch, Austria). How to implant the artificial anal sphincter? Bo... | yes |
Is Olaparib effective for prostate cancer? | converted_3871 | Is olaparib effective for Malignant neoplasm of Pelvis>Prostate? | We hypothesized that metastatic, castration-resistant Pelvis>Prostate Malignant Neoplasms with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP1 wt Allele) inhibition with olaparib.METHODS: We conducted a phase 2 trial in which patients with metastatic, Hormone refractory Ma... | yes |
Does epidural anesthesia for pain management during labor affect the Apgar score of the the infant? | converted_2844 | Does epidural anesthesia for pain management during labor affect the Apgar score of the the infant? | We retrospectively analyzed 93 consecutive single-pregnancy patients who underwent cesarean section with combined spinal-epidural anesthesia. The patients were divided into two groups, depending on the use of 6% Idiopathic Hypereosinophilic Syndrome 130/0.4: group A (461 ± 167 ml of saline-based Idiopathic Hypereosino... | no |
Can mitochondria pass through membrane nanotubes? | converted_3176 | Can Mitochondria pass through membrane nanotubes? | Membrane nanotubes (MNTs) act as "highways" between Cells to facilitate the transfer of multiple signals and play an important role in many diseases. Our previous work reported on the transfer of Mitochondria via MNTs between Myocytes, Cardiac (Myasthenic Syndromes, Congenital) and cardiac myofibroblasts (Marfan Syndro... | yes |
Can RNASeq be used for the analysis of nascent transcripts? | converted_1391 | Can RNASeq be used for the analysis of nascent transcripts? | Here, we utilize nascent RNA sequencing to document dosage compensation during transcriptional elongation., Here we show that RNA-seq can also be used for studying nascent RNAs undergoing transcription, Conversely, the nuclear fraction shows an enrichment of unprocessed RNA compared with total RNA-seq, making it suitab... | yes |
Does the histidine-rich Ca-binding protein (HRC) interact with triadin? | converted_895 | Does the histidine-rich cyclophosphamide/doxorubicin protocol-binding Protein Info (HRC) interact with TRDN gene? | The HRC effects on Ryanodine Receptor Calcium Release Channel complex location may be regulated by the cyclophosphamide/doxorubicin protocol(2+)-sensitivity of its interaction with TRDN gene., In rabbit allergenic extract allergenic extract skeletal and Myocardium, HRC binds to Sarcoplasmic Reticulum (SNCG wt Allele) m... | yes |
Is fusobacterium associated with Lemierre's syndrome? | converted_4316 | Is fusobacterium associated with Lemierre's syndrome? | Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome: an 8-year Swedish nationwide retrospective study., Lemierre's syndrome is defined as an oropharyngeal Communicable Diseases due to Fusobacterium necrophorum,, Lemierre's syndrome is a rare but life-threatening condition characterized by a... | yes |
Is adenosine signaling prognostic for cancer outcome? | converted_4194 | Is adenosine signaling prognostic for cancer outcome? | Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response., There are several agents in early clinical trials targeting components of the adenosine pathway including ADORA2A wt Allele and 5'-NUCLEOTIDASE. The identification of Malignant Neoplasms with a significant a... | yes |
Can valproic acid act as an activator of AMPK? | converted_238 | Can valproic acid act as an activator of AMPK? | Here we demonstrate that valproic acid is a novel activator of AMP-Activated Protein Kinases (AMPK), a key regulator of cellular metabolism, using primary mouse and human hepatocytes., These studies are the first to establish valproic acid and its Metabolite as in vitro activators of AMPK.[SEP]Relations: Valproic acid ... | yes |
Have thyronamines effects on fat tissue? | converted_1596 | Have thyronamines effects on fat tissue? | Intraperitoneal or central injection of 3-T(1)AM or T(0)AM into CASP14 gene, Rattus norvegicus, or Djungarian hamsters caused various prompt effects, such as metabolic depression, Hypothermia due to exposure, negative chronotropy, negative inotropy, Glucose in blood specimen above reference range, reduction of the resp... | yes |
Is DNA methylation correlated with nucleosome occupancy? | converted_2330 | Is DNA methylation correlated with nucleosome location occupancy? | Here I show that CpG Islands were associated not only with methylation-free promoters but also with nucleosome location location-free promoters., Nucleosome-free regions were observed only in promoters containing a CpG island, In contrast to the methylation-and nucleosome location location-free states of CpG-island pro... | yes |
Is Ozanimod effective for Ulcerative Colitis? | converted_4250 | Is Ozanimod effective for Ulcerative Colitis? | Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis., CONCLUSIONS: Ozanimod was more effective than placebo as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis., CONCLUSIONS: There was a high rate of continued study participation and long-term benefit ... | yes |
Is there a genetic cause of craniostenosis? | converted_4366 | Is there a genetic cause of Craniosynostosis? | Apert syndrome - TWIST1 Genes - is a rare Autosomal Dominant Disorder representing 1:65 000 cases of living newborns. Characteristic malformations of the Apert syndrome are early Craniosynostosis, microviscerocranium and II-V finger syndactyly of hand and toes with proximal phalanx of the bilateral thumb "in delta"., A... | yes |
Is there evidence to suggest that triiodothyronine has neuroprotective properties in traumatic brain injury? | converted_818 | Is there evidence to suggest that triiodothyronine has neuroprotective properties in Traumatic Brain Injury? | Exogenous SLC25A5 gene administration provides neuroprotection in a Mus model of Traumatic Brain Injury., Treatment with SLC25A5 gene (1.2μg/100g body weight, i.p.) 1h after TBI resulted in a significant improvement in motor and cognitive recovery after CCI, as well as in marked reduction of lesion volumes. , Western b... | yes |
Can SUMO affect calcium homeostasis? | converted_450 | Can SUMO affect calcium homeostasis? | Increasing SUMOylation levels correlated inversely with calcium influx in Sensory Receptor Cells., DPYSL2 gene deSUMOylation by SUMO proteases SENP1 protein, human protein, human and SUMO1 protein, human wt Allele normalized calcium influx to those in the CRMP2AAA mutant., Thus, our results identify a novel role for SU... | yes |
Is Downs syndrome associated with decreased risk of leukemia? | converted_2227 | Is Down Syndrome associated with decreased risk of leukemia? | The association of Down's syndrome and leukemia has been documented for over 50 years. Multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population., We present a case of congenital Leukemia, Myelocytic, Acute manifesting from th... | no |
Is there a role for transcription factories in genome organization? | converted_926 | Is there a role for transcription factories in Genome - anatomical entity organization? | The mammalian nucleus is a highly complex structure that carries out a diverse range of functions such as DNA replication, cell division, RNA processing, and Nuclear (incident type) export/import. Many of these activities occur at discrete subcompartments that intersect with specific regions of the Genome - anatomical ... | yes |
Do selenoproteins and selenium play a role in prostate cancer prevention? | converted_941 | Do Selenoproteins and selenium play a role in Pelvis>Prostate Primary malignant neoplasm prevention? | The selenoprotein-deficient mice exhibited accelerated development of Lesion associated with Pelvis>Prostate Primary malignant neoplasm progression, implicating Selenoproteins in Primary malignant neoplasm risk and development and raising the possibility that selenium prevents Primary malignant neoplasm by modulating t... | no |
Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | converted_187 | Are Proteasome inhibitors, antineoplastic agent good candidates for treatment of leukemia and solid Neoplasms? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo Solid Neoplasm models and inhibited organ infiltration in an RUNX1 gene model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target, We further found that ATO targets Mi... | yes |
Are there any urine biomarkers for chronic kidney disease? | converted_79 | Are there any urine biomarkers for chronic Both kidneys disease? | Kidney and urine proteomic biomarkers are considered as promising diagnostic tools to predict Chronic Kidney Diseases progression early in Diabetic Nephropathy, facilitating timely and selective intervention that may reduce the related health-care expenditures., Both blood and urine biomarkers are reviewed in this pape... | yes |
Are functional tests a good biomarker for Duchenne Muscular Dystrophy? | converted_4530 | Are functional tests a good biomarker for Duchenne Muscular Dystrophy? | North Star Ambulatory Assessment is practical and reliable., allow assessment of high-functioning boys with Duchenne muscular dystrophy., agnosis and tracking of symptom progression of Muscular Dystrophy, Duchenne usually relies on creatine kinase tests, evaluation of patient performance in various ambulatory assessmen... | yes |
Is galcanezumab effective for treatment of migraine? | converted_3006 | Is galcanezumab effective for treatment of Migraine Disorders? | Importance: galcanezumab (LY2951742), a Monoclonal Antibody [EPC] against CALCA gene (Calcitonin Gene-Related Peptide), is one of a novel class of new medicines for Migraine Disorders prevention., Conclusions and Relevance: Monthly subcutaneous injections of galcanezumab, both 120 mg and 300 mg, demonstrated efficacy (... | yes |
Can simvastatin alleviate depressive symptoms? | converted_2799 | Can simvastatin alleviate depressive symptoms? | Simvastatin-treated patients experienced significantly more reductions in HDRS scores compared to the placebo group by the end of the trial (p=0.02). Early improvement and response rates were significantly greater in the simvastatin group than the placebo group (p=0.02 and p=0.01, respectively) but remission rate was n... | yes |
Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | converted_1414 | Are Genes symmetrically distributed between leading and lagging DNA Genomic Orientation in Bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in Mutagenesis Procedure, among other damages. Because head-on collisions are more deleterious than codirectional collisions, Genes should be preferentially encoded on the leading Genomic Orientation to ... | no |
Does teplizumab hold promise for diabetes prevention? | converted_3440 | Does teplizumab hold promise for Diabetes Mellitus prevention? | Anti-CD3 Antigens Antigens teplizumab and muromonab-CD3 Antigens Antigens otelixizumab have been shown to provide C-peptide, Human, Human preservation. , Underway are secondary prevention studies with teplizumab and with abatacept., INTERPRETATION: Findings of exploratory analyses suggest that future studies of immunot... | yes |
Is Nanog repressed in pluripotent stem cells? | converted_4098 | Is Nanog repressed in pluripotent Stem Cells? | Aggregation of embryonic Stem Cells induces Nanog repression and primitive Endoderm differentiation, Interestingly, cell aggregation by itself induced Nanog repression at the outer layer, which was essential for aggregation-induced primitive Endoderm formation, early embryonic development, when downregulation of Nanog ... | no |
Does Groucho related gene 5 (GRG5) have a role only in late development? | converted_2938 | Does Groucho related gene 5 (TLE5 gene) have a role only in late development? | Groucho related gene 5 (TLE5 gene) is a HSD17B4 gene that has been implicated in late Embryo and postnatal Mus sp. development. Here, we describe a previously unknown role of TLE5 gene in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of function approaches we de... | no |
Is there any software for automated analysis of FISH images? | converted_160 | Is there any software for automated analysis of FISH images? | he study demonstrated the feasibility of automated FISH signal analysis that applying a cyclophosphamide/dacarbazine/doxorubicin protocol scheme to the automated generated 2-D projection images., A color imaging technique, multiplex fluorescent in situ hybridization (M-FISH), has been developed to ease the analysis of ... | yes |
Is there a role for TFII-I in megakaryopoiesis? | converted_4112 | Is there a role for TFII-I in megakaryopoiesis? | TFII-I/Gtf2i and Erythro-Megakaryopoiesis., TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams Syndrome (Beckwith-Wiedemann Syndrome) is caused b... | yes |
Is Tofacitinib effective for Ulcerative Colitis? | converted_2434 | Is Tofacitinib effective for Ulcerative Colitis? | Tofacitinib, inhibiting signalling via all JAK1 protein, human family members, was effective in phase 2 and 3 trials in moderate-severe ulcerative colitis., Among them, JAK1 protein, human (JAK1 protein, human) inhibitors seem to have the lead, since tofacitinib has received regulatory approval in 2012 for the treatmen... | yes |
Can IFNg induce the expression of IDO? | converted_4390 | Can IFNg induce the expression of indoleamine 2,3-dioxygenase activity? | interferon type II inducible IDO1 gene activity/GTPCH inflammation cascade, interferon type II-induced up-regulation of Indoleamine 2,3-Dioxygenase, human gene (IDO1 gene activity), IFN-γ-induced indoleamine-2,3-dioxgenase (IDO1 gene activity) , strong and positive correlation between Indoleamine 2,3-Dioxygenase, human... | yes |
Is Hunter's disease is associated with the X Chromosome? | converted_3889 | Is Hunter's Disease is associated with the X Chromosome? | Segregation analysis on five samples of families with Hunter's syndrome (158 cases overall) shows that the mutant allele segregates in agreement with Mendelian expectations for an X linked recessive, The utility of polymerase chain reaction (PCR) amplification of amelogenin Genes as a reliable and rapid means of determ... | yes |
Is the CADM2 gene associated with differences in information processing speed? | converted_3368 | Is the CADM2 gene gene associated with differences in information processing speed? | GWAS for executive function and processing speed suggests involvement of the CADM2 gene gene gene., A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=... | yes |
Is there a role of regorafenib for sarcoma treatment? | converted_1768 | Is there a role of regorafenib for Malignant neoplasm of soft tissue treatment? | regorafenib has been approved for third-line therapy., Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue Malignant neoplasm of soft tissue: a multinational, randomized, placebo-controlled, phase II trial., DISCUSSION: The design of this trial allows an assessment of regorafeni... | yes |
Is there any link between conserved noncoding elements and alternative splicing in vertebrates? | converted_1187 | Is there any link between conserved noncoding elements and alternative splicing in Vertebrates? | Some of the most highly conserved sequences occur in Genes encoding RNA-Binding Proteins, particularly the RNA splicing-associated SR Genes. Differences in sequence conservation between Plants and animal allergen extracts are likely to reflect differences in the biology of the Organism, with Plants being much more able... | yes |
Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | converted_218 | Has ergocalciferol has been shown to reduce incidence of falls in older people in clinical trials? | However, apart from the beneficial effects of 800 IU/d of cholecalciferol for reduction of falls in the elderly, causality remains yet unproven in randomized controlled trials (RCTs). , The rate of falls and the number of fallers was significantly reduced in two studies evaluating the effect of medication on preventing... | yes |
Is serotonin transported by platelets? | converted_4560 | Is serotonin transported by Blood Platelets? | activated Blood Platelets, which carry peripheral serotonin,, Platelet serotonin response was measured by serotonin augmented platelet aggregation and platelet serotonin receptor density. , Selective External Radiation Therapy was studied in the 1970s and 1980s using membrane vesicles isolated from blood Blood Platele... | yes |
Do polycomb group proteins (PcG) mediate the formation of chromatin loops? | converted_3845 | Do polycomb group Proteins (Polycomb-Group Proteins) mediate the formation of chromatin loops? | A chromatin insulator driving three-dimensional Polycomb response element (Pure Spanish horse breed (organism)) contacts and Polycomb association with the 30 nm Chromatin Fiber, the Drosophila <basidiomycetes> <basidiomycetes> gypsy insulator behaves as a conformational chromatin border that is able to prohibit contact... | yes |
Is DNA methylation an epigenetic modification of chromatin related to gene expression? | converted_994 | Is DNA methylation an epigenetic modification of chromatin related to gene expression? | DNA methylation is a Structural Modifier of DNA involved in the regulation of gene expression by controlling the access to the DNA Sequence. , Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development., DNA methylation patterns... | yes |
Do circRNAs remain untranslated? | converted_2156 | Do RNA, Circular remain untranslated? | We demonstrate that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression, Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins Cyclin-Dependent Kinases (also known as cell division protein kinase 2 or CDK2... | no |
Have the rotavirus vaccines changed the predominant rotavirus genotypes? | converted_3804 | Have the Rotavirus sp. Vaccines changed the predominant Rotavirus sp. genotypes? | This study describes the distribution and diversity of Rotavirus sp. genotypes before and after Rotavirus sp. vaccine introduction into the Australian DUOXA1 gene., G1P[8] was the dominant Genotype determination nationally in the prevaccine era (1995-2006). Following vaccine introduction (2007-2015), greater Genotype d... | yes |
Is it possible to determine the proteome of a formalin fixed and paraffin embedded (FFPE) tissue? | converted_1468 | Is it possible to determine the proteome of a formalin fixed and paraffin embedded (FFPE) Tissue Specimen Code? | ver the last few years, advances in methodology have made it possible to recover Peptides from FFPE tissues that yield a reasonable representation of the Proteins recovered from identical fresh or frozen specimens., Thus, laser capture microdissection of FFPE Tissue Specimen Code coupled with downstream proteomic analy... | yes |
Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | converted_166 | Are there any statistical methods for normalizing and identifying differential regions in histone modification Chromatin Immunoprecipitation Sequencing data? | ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification Chromatin Immunoprecipitation Sequencing libraries., In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize Chromatin Immunoprecipitation Sequencing data, and to find differential ... | yes |
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