""" mjm_1_nlevel / mjm_2c_nlevel: Generalized N-level cascaded encoder-decoder. Extends the original 3-level mjm_1 to support arbitrary number of hierarchy levels. Used for Kukanja (4-level) and other multi-level datasets. Architecture (N levels): X -> E1->h1 -> E2->h2 -> ... -> EN->H (latent) D1->C1 D2->C2+C1 DN->CN+C(N-1) + ReconDecoder head1 head2 headN """ import torch import torch.nn as nn import torch.nn.functional as F from src.models.mjm import RMSNorm, SwiGLU, FFN, _make_dec_block class mjm_1_nlevel(nn.Module): """ N-level cascaded encoder-decoder with cross-layer residual classification. Encoder chain: E1 (Linear+FFN) -> E2 (FFN) -> ... -> EN (FFN+Linear->latent) Decoder chain: D1(h1)->C1, D2(h2)+C1->C2, ..., DN(H)+C(N-1)->CN Heads: head_i(Ci) -> logits_i Residual modes: 'feature': C_{i+1} = D_{i+1}(...) + C_i 'logit': C_{i+1} = D_{i+1}(...) + proj(logits_i) 'none': no residual """ def __init__(self, input_dim=266, latent_dim=20, e_layers=3, d_layers=1, enc_hidden_dim=256, dec_hidden_dim=128, expansion_factor=2.67, dropout=0.3, output_num=None, residual_mode='feature', ): super().__init__() if output_num is None: output_num = [13, 14, 25, 27] assert len(output_num) >= 2, f"Need at least 2 levels, got {len(output_num)}" assert residual_mode in ('feature', 'logit', 'none') self.n_levels = len(output_num) self.output_num = output_num self.residual_mode = residual_mode self.latent_dim = latent_dim self.enc_hidden_dim = enc_hidden_dim # -- Encoders -- # E1: Linear(input_dim -> enc_hidden_dim) + FFN # E2..E(N-1): FFN only # EN: FFN + Linear(enc_hidden_dim -> latent_dim) encoders = [] for i in range(self.n_levels): if i == 0: encoders.append(nn.Sequential( nn.Linear(input_dim, enc_hidden_dim), FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), )) elif i == self.n_levels - 1: encoders.append(nn.Sequential( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), nn.Linear(enc_hidden_dim, latent_dim), )) else: encoders.append( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout) ) self.encoders = nn.ModuleList(encoders) # -- Decoders -- # D1..D(N-1): input from enc_hidden_dim # DN: input from latent_dim decoders = [] for i in range(self.n_levels): in_dim = latent_dim if i == self.n_levels - 1 else enc_hidden_dim decoders.append(_make_dec_block(in_dim, dec_hidden_dim, d_layers, expansion_factor, dropout)) self.decoders = nn.ModuleList(decoders) # -- Classification heads -- self.heads = nn.ModuleList([ nn.Linear(dec_hidden_dim, n_cls) for n_cls in output_num ]) # -- Residual projections (logit mode only) -- if residual_mode == 'logit': self.residual_projs = nn.ModuleList([ nn.Linear(output_num[i], dec_hidden_dim) for i in range(self.n_levels - 1) ]) # -- Reconstruction decoder -- self.recon_decoder = SwiGLU(latent_dim, input_dim, dropout=dropout) def forward(self, x): # -- Encode -- h_list = [] h = x for i, enc in enumerate(self.encoders): h = enc(h) h_list.append(h) H = h_list[-1] # latent representation # -- Decode + classify with residual chain -- logits_list = [] C_prev = None for i in range(self.n_levels): Ci = self.decoders[i](h_list[i]) if i > 0 and self.residual_mode == 'feature': Ci = Ci + C_prev elif i > 0 and self.residual_mode == 'logit': Ci = Ci + self.residual_projs[i - 1](logits_list[-1]) logits_i = self.heads[i](Ci) logits_list.append(logits_i) C_prev = Ci # -- Reconstruct -- recon = self.recon_decoder(H) return recon, logits_list, H class mjm_nlevel(nn.Module): """ N-level flat encoder + hierarchical decoder (generalizes mjm base). Encoder: Linear(input_dim -> enc_hidden_dim) -> FFN -> Linear(-> latent_dim) Decoder: N independent decoder blocks from latent, with optional residual chain. """ def __init__(self, input_dim=266, latent_dim=20, e_layers=3, d_layers=1, enc_hidden_dim=256, dec_hidden_dim=128, expansion_factor=2.67, dropout=0.3, output_num=None, is_hierarchical=True, ): super().__init__() if output_num is None: output_num = [13, 14, 25, 27] self.n_levels = len(output_num) self.output_num = output_num self.is_hierarchical = is_hierarchical self.encoder = nn.Sequential( nn.Linear(input_dim, enc_hidden_dim), FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), nn.Linear(enc_hidden_dim, latent_dim), ) self.recon_decoder = SwiGLU(latent_dim, input_dim, dropout=dropout) self.decoders = nn.ModuleList([ SwiGLU(dec_hidden_dim, dec_hidden_dim, dropout=dropout) for _ in range(self.n_levels) ]) self.input_proj = nn.Linear(latent_dim, dec_hidden_dim) if latent_dim != dec_hidden_dim else nn.Identity() self.heads = nn.ModuleList([ nn.Linear(dec_hidden_dim, n_cls) for n_cls in output_num ]) def forward(self, x): z = self.encoder(x) recon = self.recon_decoder(z) h = self.input_proj(z) logits_list = [] curr = h for i in range(self.n_levels): if self.is_hierarchical: curr = curr + self.decoders[i](curr) logits_list.append(self.heads[i](curr)) else: logits_list.append(self.heads[i](self.decoders[i](h))) return recon, logits_list, z class mjm_lr_nlevel(nn.Module): """ N-level flat encoder + LR heads (generalizes mjm_lr). Encoder: Linear -> FFN -> Linear -> latent Heads: N x Linear(latent_dim -> n_cls) """ def __init__(self, input_dim=266, latent_dim=20, e_layers=3, enc_hidden_dim=256, expansion_factor=2.67, dropout=0.3, output_num=None, # unused, kept for CLI compatibility d_layers=1, dec_hidden_dim=256, is_hierarchical=True, ): super().__init__() if output_num is None: output_num = [13, 14, 25, 27] self.n_levels = len(output_num) self.output_num = output_num self.encoder = nn.Sequential( nn.Linear(input_dim, enc_hidden_dim), FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), nn.Linear(enc_hidden_dim, latent_dim), ) self.recon_decoder = SwiGLU(latent_dim, input_dim, dropout=dropout) self.heads = nn.ModuleList([ nn.Linear(latent_dim, n_cls) for n_cls in output_num ]) def forward(self, x): z = self.encoder(x) recon = self.recon_decoder(z) logits_list = [h(z) for h in self.heads] return recon, logits_list, z class mjm_1_lr_nlevel(nn.Module): """ N-level cascaded encoder + LR heads (generalizes mjm_1_lr). Encoder chain: E1(Linear+FFN) -> E2(FFN) -> ... -> EN(FFN+Linear->latent) Heads: head_i(h_i) -> logits_i (direct Linear, no decoder blocks) """ def __init__(self, input_dim=266, latent_dim=20, e_layers=3, enc_hidden_dim=256, expansion_factor=2.67, dropout=0.3, output_num=None, # unused, kept for CLI compatibility d_layers=1, dec_hidden_dim=128, residual_mode='feature', ): super().__init__() if output_num is None: output_num = [13, 14, 25, 27] assert len(output_num) >= 2 self.n_levels = len(output_num) self.output_num = output_num self.enc_hidden_dim = enc_hidden_dim # Encoders (same structure as mjm_1_nlevel) encoders = [] for i in range(self.n_levels): if i == 0: encoders.append(nn.Sequential( nn.Linear(input_dim, enc_hidden_dim), FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), )) elif i == self.n_levels - 1: encoders.append(nn.Sequential( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), nn.Linear(enc_hidden_dim, latent_dim), )) else: encoders.append( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout) ) self.encoders = nn.ModuleList(encoders) self.recon_decoder = SwiGLU(latent_dim, input_dim, dropout=dropout) # LR heads: direct linear from encoder outputs self.heads = nn.ModuleList([ nn.Linear(latent_dim if i == self.n_levels - 1 else enc_hidden_dim, n_cls) for i, n_cls in enumerate(output_num) ]) def forward(self, x): h_list = [] h = x for enc in self.encoders: h = enc(h) h_list.append(h) H = h_list[-1] recon = self.recon_decoder(H) logits_list = [self.heads[i](h_list[i]) for i in range(self.n_levels)] return recon, logits_list, H class mjm_2c_nlevel(nn.Module): """ N-level mjm_1 + FiLM modulation of h1 conditioned on disease score + spatial coords. Context = [disease_score(1), x_coord(1), y_coord(1)] -> [B,3] FiLM: gamma, beta -> h1_mod = (1+gamma)*h1 + beta """ def __init__(self, input_dim=266, latent_dim=20, e_layers=3, d_layers=1, enc_hidden_dim=256, dec_hidden_dim=128, film_hidden=64, film_input_dim=3, expansion_factor=2.67, dropout=0.3, output_num=None, residual_mode='feature', ): super().__init__() if output_num is None: output_num = [13, 14, 25, 27] assert len(output_num) >= 2 assert residual_mode == 'feature', "mjm_2c only supports feature residual" self.n_levels = len(output_num) self.output_num = output_num self.residual_mode = residual_mode self.enc_hidden_dim = enc_hidden_dim # -- Encoders (same structure as mjm_1_nlevel) -- encoders = [] for i in range(self.n_levels): if i == 0: encoders.append(nn.Sequential( nn.Linear(input_dim, enc_hidden_dim), FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), )) elif i == self.n_levels - 1: encoders.append(nn.Sequential( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), nn.Linear(enc_hidden_dim, latent_dim), )) else: encoders.append( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout) ) self.encoders = nn.ModuleList(encoders) # -- Decoders -- decoders = [] for i in range(self.n_levels): in_dim = latent_dim if i == self.n_levels - 1 else enc_hidden_dim decoders.append(_make_dec_block(in_dim, dec_hidden_dim, d_layers, expansion_factor, dropout)) self.decoders = nn.ModuleList(decoders) # -- Classification heads -- self.heads = nn.ModuleList([ nn.Linear(dec_hidden_dim, n_cls) for n_cls in output_num ]) # -- Reconstruction decoder -- self.recon_decoder = SwiGLU(latent_dim, input_dim, dropout=dropout) # -- FiLM context network -- self.film_net = nn.Sequential( nn.Linear(film_input_dim, film_hidden), nn.SiLU(), nn.Linear(film_hidden, enc_hidden_dim * 2), ) def forward(self, x, disease_score, spatial_norm): """ Args: x: [B, input_dim] gene expression (log1p) disease_score: [B, 1] disease conditioning score spatial_norm: [B, 2] normalized spatial coordinates """ # -- E1 -- h1 = self.encoders[0](x) # -- FiLM modulation -- context = torch.cat([disease_score, spatial_norm], dim=-1) film_params = self.film_net(context) gamma, beta = film_params.chunk(2, dim=-1) h1_mod = (1.0 + gamma) * h1 + beta # -- E2..EN -- h_list = [h1_mod] h = h1_mod for enc in self.encoders[1:]: h = enc(h) h_list.append(h) H = h_list[-1] # -- Decode + classify -- logits_list = [] C_prev = None for i in range(self.n_levels): Ci = self.decoders[i](h_list[i]) if i > 0: Ci = Ci + C_prev logits_i = self.heads[i](Ci) logits_list.append(logits_i) C_prev = Ci recon = self.recon_decoder(H) return recon, logits_list, H class mjm_2c_lr_nlevel(nn.Module): """ N-level mjm_1_lr + FiLM modulation (generalizes mjm_2c_lr). Cascaded encoder with FiLM on h1, LR classification heads. Context = [disease_score(1), x_coord(1), y_coord(1)] -> [B,3] """ def __init__(self, input_dim=266, latent_dim=20, e_layers=3, enc_hidden_dim=256, film_hidden=64, film_input_dim=3, expansion_factor=2.67, dropout=0.3, output_num=None, # unused, kept for CLI compatibility d_layers=1, dec_hidden_dim=128, residual_mode='feature', ): super().__init__() if output_num is None: output_num = [13, 14, 25, 27] assert len(output_num) >= 2 self.n_levels = len(output_num) self.output_num = output_num self.enc_hidden_dim = enc_hidden_dim # Encoders (same as mjm_1_lr_nlevel) encoders = [] for i in range(self.n_levels): if i == 0: encoders.append(nn.Sequential( nn.Linear(input_dim, enc_hidden_dim), FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), )) elif i == self.n_levels - 1: encoders.append(nn.Sequential( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout), nn.Linear(enc_hidden_dim, latent_dim), )) else: encoders.append( FFN(n_layers=e_layers, model_dim=enc_hidden_dim, expansion_factor=expansion_factor, dropout=dropout) ) self.encoders = nn.ModuleList(encoders) self.recon_decoder = SwiGLU(latent_dim, input_dim, dropout=dropout) # LR heads self.heads = nn.ModuleList([ nn.Linear(latent_dim if i == self.n_levels - 1 else enc_hidden_dim, n_cls) for i, n_cls in enumerate(output_num) ]) # FiLM context network self.film_net = nn.Sequential( nn.Linear(film_input_dim, film_hidden), nn.SiLU(), nn.Linear(film_hidden, enc_hidden_dim * 2), ) def forward(self, x, disease_score, spatial_norm): # E1 h1 = self.encoders[0](x) # FiLM modulation context = torch.cat([disease_score, spatial_norm], dim=-1) film_params = self.film_net(context) gamma, beta = film_params.chunk(2, dim=-1) h1_mod = (1.0 + gamma) * h1 + beta # E2..EN h_list = [h1_mod] h = h1_mod for enc in self.encoders[1:]: h = enc(h) h_list.append(h) H = h_list[-1] recon = self.recon_decoder(H) logits_list = [self.heads[i](h_list[i]) for i in range(self.n_levels)] return recon, logits_list, H