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ADHD Genetics Research Data Manifest
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Downloaded: 2026-02-05
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Location: C:\flask-structural-api\data\research\adhd_genetics\
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SOURCE 1: PGC ADHD GWAS 2022 (Demontis et al.)
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Citation: Demontis D, et al. "Genome-wide analyses of ADHD identify 27 risk loci,
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refine the genetic architecture, and implicate several cognitive domains."
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Nature Genetics. 2023;55(2):198-208. PMID: 36702997
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DOI: 10.1038/s41588-022-01285-8
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Figshare: https://doi.org/10.6084/m9.figshare.22564390
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License: CC BY 4.0
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Study size: 38,691 ADHD cases + 186,843 controls = 225,534 participants
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Cohorts: iPSYCH (Denmark), deCODE (Iceland), PGC (international)
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Files downloaded:
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pgc/ADHD2022_iPSYCH_deCODE_PGC.meta.gz 191.3 MB GWAS summary statistics
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- Format: Tab-separated, gzipped
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- Columns: CHR SNP BP A1 A2 FRQ_A FRQ_U INFO OR SE P Direction Nca Nco
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- Contains: 6,774,224 SNPs
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- Genome-wide significant (p < 5e-8): 1,428 SNPs across 27 independent loci
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- MD5: ea57120c720e880e34f67f57483dcbb4
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pgc/ADHD2022_README.pdf 96.9 KB Study metadata document
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- MD5: 0a753096083de3e62d9292c46a089676
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pgc/ADHD2022.xlsx 15.2 KB Cohort metadata
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- Sheet 1: Study descriptors (preparor, PMID, DOI, etc.)
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- Sheet 2: Cohort details (iPSYCH1, iPSYCH2, deCODE, PGC subgroups)
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- MD5: a261cca2af06c2c13fa2fd9e80814b34
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Also available but NOT downloaded (older versions):
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ADHD 2019 (Demontis et al, Nat Genet 2019): 344 MB
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Figshare: https://doi.org/10.6084/m9.figshare.14671965
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ADHD 2018 Sex-Specific (Biol Psychiatry):
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Figshare: https://doi.org/10.6084/m9.figshare.19383299
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ADHD 2010 (JAACP):
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Figshare: https://doi.org/10.6084/m9.figshare.14671962
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SOURCE 2: ADHDgene Database (adhd.psych.ac.cn)
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Citation: Zhang L, et al. "ADHDgene: a genetic database for attention deficit
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hyperactivity disorder." Nucleic Acids Research. 2012;40(D1):D1003-D1009.
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URL: http://adhd.psych.ac.cn/
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License: Research use only (contact: wangjing@psych.ac.cn)
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Database contains: 361 curated studies of ADHD-associated genetic variants
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Files downloaded (7 XLS files):
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adhdgene/ADHDgene_SNP.xls 1.9 MB SNP variants and annotations
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- Contains: 1,391 SNPs from candidate gene studies
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- Extracted: 5,050 unique rs numbers
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adhdgene/ADHDgene_Gene.xls 2.3 MB Gene annotations
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- Contains: 359 published genes associated with ADHD
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- Extracted: 3,493 gene-like identifiers
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adhdgene/ADHDgene_CNV.xls 106 KB Copy number variants
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- Contains: 398 CNV entries
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adhdgene/ADHDgene_Other_Variant.xls 50 KB VNTRs, microsatellites, STRs
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- Contains: 173 other variant entries
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adhdgene/ADHDgene_Region.xls 32 KB Chromosomal regions
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- Contains: 128 published regions
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adhdgene/ADHDgene_PBA_Pathway.xls 19 KB Pathway-based analysis results
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- Contains: 8 PBA pathways
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adhdgene/ADHDgene_Publication.xls 149 KB Publication references
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- Contains: 361 curated studies
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NOTE: XLS files are in old OLE2 format. Require xlrd or pandas with xlrd to read
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properly as spreadsheets. Binary string extraction was used for rs number lists.
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SOURCE 3: OpenSNP Archived Data
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URL: https://archive.org/details/opensnp_data_dumps
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Status: NOT DOWNLOADED (21.4 GB, not ADHD-specific)
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OpenSNP shut down April 2025. Data archived at Internet Archive.
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Single file: opensnp_datadump.2017-12-08.zip (21.4 GB, 3,570 genotype files)
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License: CC0 (public domain)
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See: opensnp/README.txt for download instructions
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DERIVED DATA (snp_lists/)
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