from __future__ import annotations from typing import Dict AA_ALPHABET = "ACDEFGHIKLMNPQRSTVWY" def compute_sequence_features(sequence: str) -> Dict[str, float]: """Compute simple amino-acid composition and coarse biochemical summaries.""" seq = sequence.strip().upper() length = max(len(seq), 1) features: Dict[str, float] = {f"aa_frac_{aa}": seq.count(aa) / length for aa in AA_ALPHABET} aromatic = set("FWY") polar = set("STNQ") charged = set("KRHDE") features.update( { "seq_length": float(len(seq)), "frac_aromatic": sum(1 for aa in seq if aa in aromatic) / length, "frac_polar": sum(1 for aa in seq if aa in polar) / length, "frac_charged": sum(1 for aa in seq if aa in charged) / length, } ) return features