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Western Michigan University is a university based in Kalamazoo, Mich. that is home to around 20,000 undergraduates. The school has a strong sports tradition (Go Broncos!) and its urban campus offers many benefits for its students. Alumni responses to PayScale's salary questionnaire form the basis for this outline.
Former WMU students are professionally suited for a wide range of fields including the manufacturing industry, the education industry, and the health care industry. Among WMU grads, the automotive manufacturing industry is a commonly chosen career field. Median pay for those who graduated from WMU amounts to $59K.
Male graduates of WMU out-earn their female counterparts significantly, earning an average of $67K versus $54K for women.
WMU grads who become Mechanical Engineers are compensated well above average — these folks are top-earners among their graduating class, making an average $68K yearly. Also notably well-paid are Software Engineers and Operations Managers; their salaries approach around $66K and approximately $64K, respectively. On the lower end, Buyers report making about $55K.
Infamous for its meager salaries (average pay is the lowest at $55K), about one in six WMU students still call Kalamazoo, Mich. their home after graduation. On the opposite end of the pay scale is Detroit, Mich., a top-paying city for WMU grads looking to earn a larger-than-average sum (this city has a median pay of around $67K). Other cities of interest include Chicago, Ill. and Battle Creek, Mich.
WMU students with a Master of Business Administration (MBA), Finance can expect to make the most money (about $95K on average per year) compared to their fellow graduates. The degree that warrants the lowest level of financial compensation is a B.A. in Bachelor of Arts and Science (BASc) (approximately $48K on average annually).
Former Broncos with Engineering Design abilities can expect to make 24 percent more than their former classmates ($73K). WMU grads are usually competent in Project Management, and one in seven alumni continue practicing this skill in their career. Experience with Microsoft Excel, Microsoft Office, and Data Analysis is highly valued as well.
Only one in three grads for this school enjoy paid vacation days and about one-fifth of alumni get paid sick time. Health insurance benefits extend to a large number of respondents, and a strong majority of respondents sign up for dental plans. A large number of grads save up for retirement through a 401(k) plan. Alumni of Western Michigan University also take in a casual working environment, a company-subsidized cell phone, life insurance, and tuition reimbursement.
West Virginia University grads bring in salaries of around $59K, making them the most similar to WMU alumni in terms of earnings. The University of Toledo, the University of Wisconsin-Milwaukee, and Northern Illinois University are also similar to WMU.
* SAT critical reading score is not included.
* SAT math score is not included.
* SAT writing score is not included.
|
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"timestamp": "2019-04-24T07:06:57",
"url": "https://www.payscale.com/research/US/School=Western_Michigan_University_(WMU)/Salary",
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"timestamp": "2019-04-23T07:52:23",
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Get ready for breath-taking charm and architectural details as we head to Hyde Park for a peek inside this week’s Listing of the Week.
This stunning home is a Hyde Park classic. It features a spacious beautiful yard with a detached garage house and a circular side driveway. The exquisite glass windows, molding, and details throughout are just what you’re looking for. There is a finished 3rd floor with a game room, 2 bedrooms, and a full bath.
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"timestamp": "2019-04-22T08:37:49",
"url": "http://www.cincychic.com/uncategorized/listing-of-the-week-2561-observatory-ave",
"language": "en",
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Now, you can see her live on Friday, May 3rd at Dominion Energy Center.
Tickets will go on sale to the general public on Friday, March 8th at 10:00am local time and are available at the Dominion Energy Center and Altria Theater box office, by phone at (800) 514-3849 and online at etix.com.
Tickets will also be available at the Dominion Energy Center box office on the day of the on-sale and the day of the show. For more information, visitdominionenergycenter.com.
Sykes was previously seen on several television shows over the past two years. Her Own special “Herlarious” which aired in July highlighted female comics. Last year she made a return to HBO’s “Curb Your Enthusiasm” starring opposite Larry David. In 2010 she starred on her own late night talk show on FOX, “The Wanda Sykes Show”.
In 2009 her second HBO stand up special “I’ma Be Me” premiered. It was taped at the Warner theatre in Washington DC where she tackled topics like the first black president, gay cruises, being a new mom and aging.
The special was nominated for two 2010 Primetime Emmy awards: Outstanding Variety, Music or Comedy Special and Outstanding Writing for a Variety, Music or Comedy Special.
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One thing I can never understand is the law requiring the use of seat belts in cars. Of course, seat belts are a good thing and no one can argue with the logic that seat belts help save lives in accidents. However, I personally do not like using seat belts as I find them restrictive and I think this is one area where the choice of belting up or not should be left to the individual.
It is to the credit of the Traffic Police that they have adopted a soft approach and have enforced this law by reminding rather than fining offenders strictly but I feel this issue is a little like euthanasia. If I have a death wish, this is my choice and my problem right? After all, people who knowingly put themselves at risk of death such as smokers and alcoholics are not fined for their bad habits.
The real reason is probably the Gahmen needs to find more reasons to collect money from citizens. They have already managed to tax the smokers badly but this seatbelt thing is one area that they could get their hands on..
You have got to be kidding me. Are you running out of reasons or what?! Seems to me like you're clutching at straws and imaginary reasons to hate Singapore.
I mean seriously! Why should we give way? We don't need traffic lights, it's a waste of taxpayers' money! Let's just use our INSTINCT, I say!
You are good,yo. Keep churning the other few hundred, retarded, oops, I mean, compelling reasons, yo. We are all looking forward to some lemons everyday!
you are so crazy. hope you die from a car accident while ya dont wear seatbelt. fyi, in alot of countries including australia, seatbelt rules are even more strict.
CAN YOU JUST SHUT UP. PLEASE,if you have a death wish, just die yourself. Don't make others die. By enforcing this law, its for Singaporeans' own good. So if you dont wanna put on your seatbelt, just shut ur mouth up.
I know this is an old post, but it did make me chuckle.
Have you seen the damage a body can do when it is ejected from a car at speed?
It will happily go through several windscreens. I will let your imagination do the rest.
Are you THAT bored? Obviously you won't make it 1001. Know why? You're a fool who gave himself the right to whine about SIngapore. You're a coward. A coward who hides behind a computer a screen.
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"url": "http://ihatesillypore.blogspot.com/2009/01/reason-0015-compulsory-seat-belts.html",
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I'm going to be a bit busy this week, so I thought I'd regale you with tales from my illustrious past...which is to say, here are all the reviews, interviews & articles I contributed to ComiX-Fan, the website where I cut my interviewing and reviewing teeth in late 2005! The website was moved but all the links work all over again. Who cares if there are no pictures? Now you can see how diverse my comics tastes really are! Entries are sorted by type of feature and date. Dig in!
Enjoy, and I'll be back later this week with more fun stuff!
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{
"timestamp": "2019-04-25T01:53:33",
"url": "http://www.delusionalhonesty.com/2011/09/from-vault-comixfan-reviews-interviews.html",
"language": "en",
"source": "c4"
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Our 5×7 Pro Live Pitch Screen is perfect for softball BP. Live pitching is what this frame does best!
Our 5 x 7 Pro Live Pitch Screen is a great alternative to the original Pro 5 x 7 flip screen. It was designed for softball but also works well for baseball underhand flip! Pro wheels allow easy maneuverability on and off the field. It is available with different netting options along with all welded aluminum or galvanized steel construction. All Burbank frames are made here in the USA at our facility by an experienced welder.
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"timestamp": "2019-04-25T14:16:21",
"url": "https://burbanksportnets.com/product/5x7-pro-live-pitch-screen/",
"language": "en",
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Amongst the chaos within the Demon Imperial Hall, the Little Demon Empress and Yun Che had finally arrived. It could be said that they had arrived just in time, yet it was extremely thrilling. That was because if they had arrived just a moment later, as soon as Yun Qinghong’s blood colored lightning exploded, he would undoubtedly die.
On their return trip to the Demon Imperial Hall, Yun Che had thought of tens of different kinds of dazzling entrances, along with a similar number of sufficiently tyrannical and mighty scripts. After all, he had the Little Demon Empress beside him as backup, so even facing Duke Ming, he could show off to his heart’s content.
The chaos in the Demon Imperial Hall made him scrunch his eyebrows, and the moment he saw the state in which Yun Qinghong and Mu Yurou were in, all of his plans were immediately tossed out the window. He shouted startledly, without care for anything else, he rushed down with his fastest speed.
Based on Yun Che’s abilities, he could tell with a single glance that even though Mu Yurou was injured, she was not in dire straits. However, Yun Qinghong’s face was white and lips were purple; his shirt was mostly stained red with blood, and not only was he seriously injured, his vital energy had been mostly used up, so Yun Che did not even spend even a moment thinking He immediately pressed his right palm onto Yun Qinghong’s chest and channeled the Great Way of the Buddha at full power, absorbing the essence of heaven and earth and imbuing it into his body.
“Che’er… you’re still alive… my Che’er is not dead… very good… very good…” Mu Yurou did not care where she was, and currently, nothing else mattered to her anymore. She simply threw herself and tightly hugged her son; her tears fell like rain, sobbing without sound.
“Good... “ Yun Qinghong shut his eyes, and it was only a single, short word, yet it carried an enormous amount of gratification. At that moment, his body was heavily injured and had lost an enormous amount of blood essence. Although the Little Demon Empress had returned, they were still surrounded by powerful enemies, and based on the strength which Duke Huai possessed, they still had not escaped the crisis. Yet at the moment, he still smiled in tears; he was not a single bit anxious, resentful, or wrathful, only gratified and satisfied… Their whole family had finally been reunited, and this was an extravagant wish which he thought he would never achieve in his lifetime ever again.
The Little Demon Empress’ voice brought along a wave of extremely heavy pressure... heavier by who knew how many times it was in the past. Even if one did not look at her, just by hearing her voice, one would not be able to breathe and feel their whole body go stiff.
The Little Demon Empress, who originally was thought dead, appeared on the day of the new Emperor’s ascension, even bringing along the Golden Crow’s imprint and returning with the awakened Golden Crow’s bloodline! This was undoubtedly the Illusory Demon Realm’s most shocking and most embarrassing sight.
The Demon Empress’ fury, that wave of shocking pressure, caused everyone to choke for a moment. Several of those who had hurriedly defected to Duke Huai over the last few months were in a confused state of mind. They were scared witless, completely at a loss. However, even more of the powerhouses… especially those who had belonged to Duke Huai Palace since long ago, looked at each other’s expressions, and gradually, their initial confusion faded away So what if the Little Demon Empress had risen from the grave? The strength of Duke Huai’s side had long surpassed that of the Little Demon Empress’. Within the past few short months, it had once again inflated by a large degree… Apart from the tens of thousands of years of prestige and might the Demon Emperor’s clan possessed, what did the Little Demon Empress have to compete with Duke Huai!!
The appearance of the Little Demon Empress was simply another inconvenience in this ascension ceremony! Today, not to even mention the Little Demon Empress, even if the former Demon Emperor was revived… they had no intentions of stopping Duke Huai’s ascension!
Facing the Little Demon Empress, Duke Zhong words were fierce with no trace of politeness, criticising loudly with absolutely no apprehension. Evidently he did not take her to be the emperor of the Illusory Demon any longer.
“You…” The moment Yun Che spoke, Helian Kuang’s heart violently bulged. The shadows from four months ago suddenly awakened, causing him to not dare to talk back for a moment.
Yun Che’s words silenced the entire hall for a moment. Duke Huai gave a cold laugh and said darkly, “Yun Che, you have said enough! This emperor originally had some respect for your Yun family, however… today, you have greatly disappointed this Emperor! Yun Qinghong belittled this emperor, this emperor could tolerate. Now that you, Yun Che, have appeared, this emperor already knew that you would also say the same things as Yun Qinghong… just as expected! Your Yun Family has spared no effort to frame this emperor!
Yun Che looked at him coldly with his eyes expressing his playfulness as if watching a clown striving to give a good performance.
Duke Huai’s expression became even darker. “Your Yun Family is doing your utmost to frame this emperor Even though it is shameless to the extreme, it could be considered a type of loyalty to the Demon Emperor bloodline, thus this emperor can tolerate it! However… Little Yun Che, you could have simply stopped at slandering this emperor, you actually went as far as to slander my royal father’s reputation!
The Little Demon Empress’ grey clothes swept out as she suddenly stretched out her hand, and the imprint on her palm instantly radiated a pure gold brilliance.
Duke Huai’s bodyguards flashed, wanting to rush in front of him. However, in the very next instant, though nobody could see any other movements from the Little Demon Empress, a flame glowed on Duke Huai’s body, and after that, an ear-piercing “ping” of something shattering could be heard.
Duke Huai’s personal space was directly shattered, releasing a jade seal with the glow of a scarlet flame, and under the gaze of everyone present, it flew out of Duke Huai’s shattered personal space, then flew straight into the Little Demon Empress’ hand under a wave of irresistible suction force, leaving a scarlet trace.
The hall was completely silent for a moment, and even the faces of the experts on Duke Huai’s side had completely changed. Their expressions were full of fear, and Duke Huai’s expression was even more stiff.
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Bullseye Purple Opalescent Powder Frit.
Gold Purple is a colour which strikes or matures to target. After firing to a full fuse the colour changes from a dark blue to a deep purple.
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{
"timestamp": "2019-04-25T10:07:48",
"url": "https://www.warm-glass.co.uk/product_reviews_write.html?products_id=3155&cPath=98_160",
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Bathroom Bowed Shower Curtain Rod Small Shower Curtain Rod Lace Curtains With Attached Valance Touch Up Bathroom Curtain Ideas Lace. Extra. Valance.
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"timestamp": "2019-04-22T07:14:30",
"url": "http://www.aimeescoffeehouse.com/touch-up-bathroom-curtain-ideas/bowed-shower-curtain-rod-small-shower-curtain-rod-lace-curtains-with-attached-valance/",
"language": "en",
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Greg Vetter came in and showed me how to manage the onslaught of emails and requests coming in. His system allowed me to get to “Inbox Zero” every night! AND I have time now to handle my real job! I am very grateful to report that since working with Greg my business has completely turned around.
I cannot say enough how thankful I am to have found you, and brought you on board to improve my productivity. I’ve been through many seminars on time management and the like, and your consultation is one of two life changing experiences I have had in my professional career.
I now have been using Greg Vetter’s organizational system for one year, and in that year have found that my organizing, planning and productivity levels have skyrocketed…The ultimate compliment I can pay regarding this system is the fact that I am now arranging for each of my 18 new direct reports to be “Vetterized” in order to increase our team’s productivity.
...the amount of work that I can now do for the bank has doubled.
We all work hard at NationsBank, but I can safely say that the amount of work that I can now do has doubled.
Vetter Productivity has given me at least two more hours of work time each day.
...the most direct impact on my productivity.
I found your course to offer the most direct impact on my productivity, than any other training course or seminar I’ve attended.
...Vetter Productivity was cited as one of the strengths of our operation.
The work you have done with our team to develop “lean office” work flow and record keeping practices has increased our productivity and the accuracy of our information.
Our audit was very successful with the auditors describing our operation as the new “gold standard” for the Coca-Cola operations. CSP was the first operation to have “Strengths” identified and our implementation of Vetter Productivity was cited as one of the strengths of our operation.
The auditors were impressed at how quickly (5 seconds) we could produce the instrument calibration, analytical results, COAs, lot information, etc. that they audited.
My production is up over 70% since you began working with me.
In two days’ time I accomplished what previously would have taken me a week to accomplish.
...really making a difference in people’s lives.
Congratulations on and thank you for an outstanding performance. Greg, what you are doing is really making a difference in people’s lives.
I can put my hands on anything I need within a fraction of a SECOND.
Thank you for helping me create a work environment that WORKS! I can put my hands on anything I need within a fraction of a SECOND. This is exciting stuff. Not only do I work better, I feel better because I am in control.
I asked someone to time me... It took only 11 minutes.
Recently we had new carpet installed. Each person had to pack everything, except furniture, in boxes, place them in the hall and reverse the process the next day after the carpet was installed.
It took me 30 minutes to pack my office in boxes, mark them and move the boxes outside my office. I asked someone to time me the next morning when I restored my office. It took only 11 minutes. Some employees spent days restoring their office.
As I have assumed additional responsibilities and travel more, I would have been totally lost and overburdened without the Vetter Way. Your system is an organized approach to living and succeeding in a very busy, over-communicated, technical world. With all the memos, e-mails, faxes, phone calls and people coming at me each and every day, your system provides order, solutions, and a way to function with a positive mind and attitude.
Hands down – YOUR’S WAS THE BEST!
I have spent the last 22 years with three major corporations: Proctor and Gamble, Kayser Roth and Coca-Cola. During that career I have participated in excellent training seminars and workshops. Hands down – YOUR’S WAS THE BEST!
...it has changed my life.
This comes to thank you for your productivity seminar–it has changed my life.
I’ve earned more than I’ve paid him in the time he has saved me.
It’s difficult to measure all the time and effort he saved, but I roughly calculate that the new system–in force for nearly two months–has added no less than 1 billable hour each day to my workday. I’ve earned more than I’ve paid him in the time he has saved me.
Weinstein, Rosenthal, Tobin & Caldwell, P.C.
The system’s greatest benefit is not that my desk is organized, but that I have clarity of mind to focus on priorities and not get sucked into the evils desk management that add no value.
The participants are still talking about how helpful your system will be in their office. I appreciate the time and effort you obviously put into the presentation. It was well organized and professionally presented in an interesting and energetic manner.
I feel I am about 20% more productive.
Productivity has increased by twenty-five percent.
...very relevant to the work place.
Unlike a lot of highly-promoted seminars available which promise grandiose results, your program is specific, disciplined and very relevant to the work place.
Your system is simple yet quite effective.
Your system is simple yet quite effective. I wish I could change all of my bad habits as easy as you helped me change my organization skills.
I wanted to take the time to thank you for making the best investment in myself and my business that I have ever made.
...but this is the only one I would recommend.
I probably only use the program at 75 percent of its capacity and it has made an unbelievable difference…I could be a spokesman for your company because I feel so strongly about how much more efficient it has made me… I have had many time management classes and seminars in my career but this is the only one I would recommend.
...you’ve given me a tool and a process which are really working.
Now that I count myself among the ranks of the ‘converted’, I can honestly say I have improved my ability to: focus on priorities; delegate more effectively; communicate more clearly and concisely. In short, you’ve given me a tool and a process which are really working.
...hours worked per week has decreased from 75 to 55.
The number of hours worked per week has decreased from 75 to 55.
Awesome to say the least! I always thought I was pretty organized but knew I could use some improvement. What I did not realize is how much improvement I needed, I was happy finding stuff in five minutes and thought you were crazy with the thought to find it in 5 seconds! I will definitely be using many if not all of what we covered in our short 4 hour class.
...best trainings I have had in operating in our electronic age.
I took your course at EPA a few years ago and it was one of the best trainings I have had in operating in our electronic age.
...quite an impact on our organizational style.
Because of your hands-on-approach and clear presentation, you had quite an impact on our organizational style.
I would highly recommend this system to anyone who is trying to gain some sanity and bring some control into their life.
...my work environment has been truly transformed.
There is no doubt in my mind and the mind of others who walk into my office in amazement, that my work environment has been truly transformed.
I learned more...than in my total M.B.A. program.
In these important areas of need, I learned more and was helped more by you in our twelve hours of intensive effort together, than I did in my total M.B.A. program.
Thanks for the kind words and good wishes Greg. You have left an indelible mark on my life and for that I am grateful. I will stay in touch.
I am already seeing huge benefits!
I really enjoyed your presentation at our conference the other day and have already started using Outlook for my action items as you suggested. I am already seeing huge benefits! I wish I had heard that message years ago! Thank You!
...one of the most valuable days of my life.
Thank you for one of the most valuable days of my life.
I have to admit, I was skeptical at first. But your system does work.
I now feel completely in control of my work environment and not so victimized.
In using your organization system, my productivity and that of my secretary has increased tremendously.
I have never been so productive.
I am still using the system. I have never been so productive.
Thanks for your help, especially your follow-up after our sessions. I am very much aware of your sincere interest in helping your clients achieve success with your program.
Just a quick note to say your system saved us money and time and everything for a decade at the NBA. NOW it has done the same for my Dean of Students office for the last decade! If you work in my office you must use the Vetter Productivity System! Just thought I’d let you know how universal, transformational and helpful all your teachings and learnings with me still are!
...changed our organization... in a number of positive ways.
The Vetter Productivity System is a comprehensive and thought-out plan for personal and organizational productivity which changed our organization and our employees in a number of positive ways.
I can easily recommend Greg Vetter as a person whose product is sound and whose approach is solid.
We began the year at approximately a 20% rejection rate. We challenged the team with a mid-year goal of bringing this down below 7% and they have achieved it!!
As a complex we have reached a rate of 5.89% leading the Region which overall came in at 9.37%, the Division at 9.56%, and the Firm at 10.35%.
...better system for how I work.
Understanding the difference between processing and producing and separating those tasks was huge for me. Giving up working from my In-Box has been an eye opener. Unplugging every day to produce has been great. In addition I’m getting better at “batching” work and it’s downright exciting to become more efficient. I’m more effective now, contributing at a higher level, and I have more time for good decision making.
I now have a system of not only organization – but a better system for how I work.
...what I learned ... was life changing for me.
I wanted to let you know that what I learned in your training session was life changing for me. I’m being very serious. I did what you advised, customized it to fit my work life and have been doing and managing my work load so much better. I even have applied some of it to my home life. I just want to say thank you for teaching me how to change the way I “THINK” about working in both work and life. I wish I could teach this to my son but he is only 1 yrs. old. Please note that the change for me wasn’t an easy one – I had to work on it but it has been so worth it!
|
{
"timestamp": "2019-04-23T03:53:38",
"url": "http://vetterproductivity.com/testimonials/",
"language": "en",
"source": "c4"
}
|
Make sure you’re enrolled to vote to have your say in this year's local elections.
The voting period starts on Friday 16 September 2016. Election day is Saturday 8 October 2016 and voting closes at midday on that day.
If you're a resident of Nelson City and already enrolled on the parliamentary electoral roll for the general election, you're automatically enrolled to vote in the 2016 local elections.
If you're not on the parliamentary electoral roll in the Nelson City area and want to enrol, or if you're not sure if you're enrolled and want to check, visit www.elections.org.nz/enrol or call 0800 36 76 56.
To get an enrolment form, pop into any PostShop or freetext your name and address to 3676.
If you own and pay rates on a property in Nelson City, but don’t live in the area, you may be eligible to enrol on the non-resident ratepayer electoral roll.
A company or society paying property rates can also qualify as a ratepayer elector.
For more information on this year’s elections visit the Local Councils' website.
|
{
"timestamp": "2019-04-19T19:07:41",
"url": "http://www.nelson.govt.nz/council/elections-2019/previous-elections/elections-2016/how-to-vote",
"language": "en",
"source": "c4"
}
|
The Smithsonian Channel ought to give us some interesting stuff to view. We anticipated that the Mystery of the Hope Diamond might be that bauble of historical documentaries. Instead, they try to debunk their own information.
Ostentatious beyond all blue diamonds, yet still mysteriously cut down after it was stolen in 1792, the Hope Diamond remains a big draw. And that is despite its legendary curse.
Blue diamonds are considered the least happy for those who want a date with carbon facets. This one, purportedly, served as the eye of an Hindu goddess unceremoniously snatched by a thief.
Yes, like King Tut’s tomb, the Hope Diamond gives its owners a run for their lives, and their money. It cost Marie Antoinette her head as she so admired it.
There are gaps in its history—long disappearances—as we do not know who cut the diamond down to its present 45-carat size. It once weighed in at 70 big carats.
And we can’t say that fool who pared it down was toast soon thereafter. We presume so, based on this pedestrian documentary astutely narrated by Kim Basinger.
Of all the intriguing details that pop out of this 46-minute featurette, it is that in the 1960s, scientists discovered that ultra-violet light has a weird effect on the diamond: causing it to glow in the dark like a red ember.
Size does not fit all curses: speculators think size makes the red shine last longer than most diamonds sitting in the dark after basking in ultra-violet light. Who knows when it comes to cursed stones?
The curse may take longer than six months to hit the owner, but when it does, look out. It’s a tough nut for sure, about the size of a cheap walnut.
Right now, the crown jewel of diamonds is housed in a bullet-proof and bomb-proof case at the Smithsonian, donated there by Harry Winston because you can’t get a good price for the damn thing on the market.
The Hope Diamond is named after a greedy banker named Hope, not Bob, one of its cursed 19th century holders. It now is on display and has as many visitors as Mona Lisa every year. Look, but don’t own up to it.
The film falls on its own lightweight when it tries to prove the curse of the diamond is fake news. Their expert insists only old people (already apparently facing death) have expired upon owning it. This undercuts their own information about the young family members who were collateral deaths from ties to the diamond.
This diamond is nobody’s best friend.
|
{
"timestamp": "2019-04-22T22:03:25",
"url": "https://ossurworld.com/tag/smithsonian/",
"language": "en",
"source": "c4"
}
|
Dunlop`s Grandtrek PT2 is designed for SUVs and 4WDs and delivers a comfortable, quiet on-road ride rather than a tyre designed with off-road capabilities in mind.
Noise and ride comfort optimising block rigidity and to reduce irregular wear.
The Grandtrek PT2 demonstrates four key characteristics that focus on comfort, quietness, high speed stability and wet performance.
|
{
"timestamp": "2019-04-23T03:58:16",
"url": "https://www.blackcircles.com/tyres/brands/dunlop/grandtrek-pt2a",
"language": "en",
"source": "c4"
}
|
Brown, Driver, Briggs and Gesenius. "Hebrew Lexicon entry for B@mow". "The KJV Old Testament Hebrew Lexicon". .
|
{
"timestamp": "2019-04-19T13:10:06",
"url": "https://www.biblestudytools.com/lexicons/hebrew/kjv/bemow.html",
"language": "en",
"source": "c4"
}
|
Health Benefits from Swimming. Are you suffering from a back injury, a knee injury, arthritis or Chronic pain? Did you know that water exercise therapy and swimming are the most widely used rehabilitation programs subscribed by doctors? Many positive results can be obtained by simply exercising in a swimming pool. Some of these health benefits include strength improvement, weight loss, muscle gain, aerobic cardiovascular improvement that reduces the risk of heart disease and good mental health. Swimming is the most recommended exercise by doctors because of it's resistance when training in water and it's low impact on joints. There is no pounding or compression on the joints or spine when swimming in comparison to jogging, running, biking or aerobic classes. Swimming will definitely strengthen your muscles. Whether you swim for exercise or you want to try it for rehabilitation, the benefits of swimming are unmatched. At any age or shape swimming or water exercise will improve your lifestyle. Visit this link to learn more about the great health benefits from swimming when experiencing back or chronic pain. Call Merodyamic Pools today for your free in ground swimming installation consultation.
|
{
"timestamp": "2019-04-25T23:41:46",
"url": "https://merodynamicpools.com/health-benefits-from-swimming/",
"language": "en",
"source": "c4"
}
|
Dance performances are simultaneously streamed and recorded using Matrox Monarch HDX.
Dance is a form of artistic expression. Poetry in motion. Freedom for the body and soul. Nobody knows this better than Dr. Ross McKim, who was Principal and Artistic Director at the internationally recognised Rambert School of Ballet & Contemporary Dance for 30 years. Rambert School is one of a small group of first-level professional dance schools in the world and is located in London. It is a place of dance and choreographic innovation offering a foundation degree and BA in ballet and contemporary dance.
A farewell celebration to honour Dr. McKim’s retirement was the impetus for the school to invest in live streaming equipment because many invitees from around the world—past, present and prospective students and staff; potential donors; critics; and interested parties from the wider dance community—could not attend in person. The school also wanted an easy means of recording and archiving the event.
In addition, Amanda Britton, the school’s current Principal and Artistic Director, wanted a way to record student performances for teachers to provide feedback and for use on websites and social media that was faster and easier than using a cumbersome DVD recording process.
After a thorough study of available products, Mark Underwood, an independent technical consultant, encouraged the school to select the Matrox Monarch HDX dual-channel H.264 encoding appliance. It provides both the streaming and recording capabilities they were looking for, is cost-effective, compatible with their existing SDI and HDMI cameras, and easy to use.
Large events like the farewell celebration are held in-house or at external venues, such as the Lilian Baylis Studio Theatre. For these, a Panasonic HE2 camera provides a wide shot of the stage and two GoPro Hero4 cameras provide alternate angles. The cameras are connected to a switcher. From the switcher, an HDMI output goes to the Monarch HDX appliance for streaming and recording. Analogue audio is mixed separately and fed into the Monarch HDX from the sound desk. The Monarch HDX keeps the audio and video in perfect synchronisation.
While one Monarch HDX encoding channel outputs an RTMP-compliant stream to a Wowza server for internet distribution, the other channel is used concurrently for recording. If the event is held in-house, the recording is done directly to storage on the network. Local USB storage or an SD card is used for external events.
For simple shows and assessments in-house, the Panasonic HE2 camera is connected straight to Monarch HDX via HDMI. Both of Monarch HDX’s encoding channels are used for recording. One output is sent to a central archive for school records while the other is directed to network storage for immediate playback and performance assessment. Some recordings are edited and uploaded as dance videos to the school’s website or to social media.
School’s stage where events and performances are recorded using Matrox Monarch HDX.
Unlike the pirouettes, adages and jumps that require hours and hours of training and practice, the Monarch HDX is so simple to use that any of the students or the rehearsal director can learn to operate the pre-configured unit via on-device buttons in a moment. Student dancers with absolutely no A/V experience are able to record their own personal videos.
The new process with Monarch HDX’s H.264 encoding makes recordings available to students and teachers immediately, in a shared network location.
Monarch HDX’s versatility lets them simultaneously stream to the school’s website using Wowza Streaming Engine, ensuring every online attendee access to the performance, and record to network storage or an external drive, depending on the event’s requirement.
As envisioned, the school streamed Dr. McKim’s farewell celebration on its website without any hitches. The quality of the streams was not compromised despite having to use a low bitrate of 700 Kbps due to the limited internet upload bandwidth of 1 Mbps at the school. Absentee invitees were thrilled to be able to view the program live and pay tribute to this exceptional leader.
|
{
"timestamp": "2019-04-23T11:57:21",
"url": "https://www.matrox.com/video/en/press/insights/Rambert-School-of-Ballet/",
"language": "en",
"source": "c4"
}
|
Competition – SPFL Premiership match: Dundee United v Dundee, Sunday 24th May.
Disciplinary Rule 202: In that the above match you committed an act of Excessive Misconduct by biting Jim McAlister of Dundee FC upon his leg to his injury. That this act constituted an A2 Sending-Off Offence of Violent Conduct as provided for in Section 3 of Annex C to the Judicial Panel Protocol, and was aggravated by the degree of physical violence used.
|
{
"timestamp": "2019-04-18T22:33:33",
"url": "https://www.scottishfa.co.uk/news/notice-of-complaint-nadir-ciftci-dundee-united-fc/",
"language": "en",
"source": "c4"
}
|
The FoodShare program is an entitlement program for those who are eligible to assist them in purchasing food. The goal of the program is to make it easier for people to have a healthy, adequate diet. The program has income guidelines for eligibility. The amount of the FoodShare benefit is based on household size and income.
Once eligible for the FoodShare program, families will receive a QUEST card which can be used to make their food purchases. Further information on the FoodShare program can be seen online.
|
{
"timestamp": "2019-04-24T20:28:25",
"url": "http://investozaukee.org/302/FoodShare",
"language": "en",
"source": "c4"
}
|
On the drug route from Afghanistan, Pakistan has the highest number of addicts globally.
Pakistan is struggling with the highest number of drug addicts in the world, according to medical authorities there.
Officials have said there are at least five million people using heroin, opiates, or other mind altering substances across the country.
The United Nations office on drugs and crime estimates around 40 per cent of Afghanistan's heroin and morphine goes through Pakistan, and some of that is used by the more than 600,000 Pakistani opiate abusers.
Nai Zindagi, or New Life in English, is the country's biggest rehabilitation programme. Every day it helps around 22,000 addicts across Pakistan.
It gives clean needles to stop the spread of HIV, advises on health issues and gives addicts the chance of getting clean.
Al Jazeera's Alan Fisher reports from Bara Koh in Pakistan.
|
{
"timestamp": "2019-04-23T18:39:17",
"url": "https://www.aljazeera.com/news/asia/2010/01/201011283214750225.html",
"language": "en",
"source": "c4"
}
|
Remote consultations (over the phone, via video link or online) are on the increase. They can save doctors’ time, benefit patients and help meet public demand for faster access to medical advice.
Following guidance is key as there are potential patient safety risks to consulting remotely. It's important to identify and manage those risks, and to recognise that remote consultations are not always the right choice.
Is a remote consultation appropriate?
The 3Cs - consent, capacity and continuity of care - are key issues to remember when you are advising or prescribing treatment for a patient via remote consultation.
Give patients information about all the options available to them (including the option not to treat) in a way they can understand.
Tailor the information you give, and the way you give it, to patients’ individual needs, and check that they’ve understood it.
If you’re not sure a patient has all the information they want and need, or that they’ve understood it, consider whether it is safe to provide treatment and whether you have valid consent.
You must make sure you can assess a patient's capacity. If a patient lacks capacity to make a decision, consider whether remote consultation is appropriate, including whether you can meet the requirements of mental capacity law.
If you’re not the patient’s GP, ask the patient for consent to get information and a history from their GP and to send details of any treatment you’ve arranged.
If the patient refuses, explore their reasons and explain the potential impact of their decision on their continuing care.
If the patient continues to refuse, consider whether it is safe to provide treatment.
Make record of your decision and be prepared to explain and justify it if asked to do so.
Dr Best works for an online pharmacy, assessing patients’ requests for private prescriptions.
Dr Best reviews the questionnaire submitted by a 28 year old patient, Lauren, who has requested painkillers for acute back pain. Lauren has indicated that the pain was the result of an accident – she tripped and fell in the street.
Dr Best is concerned about the request since the painkillers Lauren has asked for are very strong. He also notes from the pharmacy’s records that Lauren has received the same medication for the same problem on three previous occasions. Dr Best is concerned that this may indicate an underlying issue – with the injury, Lauren’s pain management or possibly medicines misuse.
Prescribe the painkillers to help Lauren with her immediate pain, but tell her that next time she should see her own GP?
Decline to prescribe and advise Lauren to seek face-to-face medical advice about her back problem?
Contact Lauren asking for further information about her injury, current pain levels and previous prescription requests?
As Lauren’s request was submitted online, Dr Best can’t discuss the request with her or carry out an examination. He also has limited opportunities for follow-up. As there is doubt about the cause of Lauren’s pain, which he isn’t able to resolve, Dr Best decides not to prescribe painkillers for her. He recommends that she make an appointment to see her GP or another doctor who can assess her condition and treatment needs appropriately.
Remote consultations (online or via telephone or video link) can improve patient access to advice and treatment, but they are not always an appropriate alternative to seeing a patient face-to-face.
When consulting remotely, it’s important to consider the limitations of the medium by which you are communicating with the patient. You should not prescribe unless you are satisfied that you have sufficient information to do so safely.
"We welcome innovations in medical practice that enable good care for patients, and support the use of remote prescribing that follows our clear prescribing guidance used in consultation with a patient in person or online."
Follow the GMC guidance on consent and good practice in prescribing.
|
{
"timestamp": "2019-04-19T18:23:50",
"url": "https://www.gmc-uk.org/ethical-guidance/ethical-hub/remote-consultations",
"language": "en",
"source": "c4"
}
|
Download the most popular free messaging app of "WhatsApp Messenger APK" which is easily obtainable for Android phones and all other smartphones. It has been considering as the most secure communicating application. Make unlimited free voice and video calls to your family members, friends, co-workers and business partners throughout the countries with WhatsApp APK. Talk to the people whom you love most for a long time for all around the world without paying any charges. It just uses your phone's internet connection to make video and audio calls globally. It is really simple, reliable and useful app to send free messages and free calls. Share videos, documents, send voice and text messages all is free with WhatsApp. Make free video calls and talk face to face with your loved through WhatsApp. It is really responsive so you can send instant messages with it. Speak freely with WhatsApp. The calls and messages are fully secured so, only you and the person you are communicating with can read or listen to them. The features of this useful messenger app are not ended here scroll down to read more interesting and useful features.
Say what is on your mind with WhatsApp. Simply tap and speak and send your voice message to your contacts. It is really perfect app to say a quick hello or long conversation. Now your voice message says it all.
whenever you fail get notifications due to interruption of data network or turn off your phone due to charge, WhatsApp will save your recent messages up to the next time you use the app. and you can also send the messages even your contact is offline or out of Internet connection when your contact is in the range of Internet or Wi-Fi he/she will get your message.
Sharing of documents is easier than ever with WhatsApp APK. You can send documents of any format through WhatsApp. Share or send PDFs, MS office documents, slideshows, spreadsheets and many other forms without the hassle of email or file sharing applications. You send or share documents up to 100 MB, so it is easy now send or share documents through WhatsApp APK.
It is a really good application to instantly share photos, videos and share other moments that matter you. You can even take a picture or capture a moment or share a make video with a built-in camera of your Android device and share it directly with WhatsApp.
WhatsApp keeps safe of your most personal data and moments as you share on it. The end-to-end encryption of this amazing app make your messages and calls more secured so, only your and the person you are communicating with can read or listen to them and nobody in between, not even WhatsApp itself cannot access your privacy. It is really secure communicating app ever.
Speak freely with WhatsApp APK after download and install it on your Android smartphone from below given download URL link. With free video calls, you can have face to face talk with your family members, friends and loved ones even they are living abroad in the country. You can also make voice calls to your loved ones, family member and even all your contact with WhatsApp free APK. For video and voice calls it to use your phone’s Internet data instead of your cell plan’s calling packages. So, you don’t need to worry about costly calling rates. But remember that data charges may apply.
WhatsApp is very simple and much reliable messaging application that allows you to send and receive text messages from your friends, colleagues, and family for free of cost. It just uses your mobile data to send messages so; you don’t need to pay extra charges for texts messages.
You can easily make a different category of groups such as a group of friends, coworkers, family and so on to keep in touch with them. Make a group of up to 256 people at once. You can share messages, photos, videos and audios; group chats, and shares other files with the groups. Name your group according to your taste of style and get notifications from them and more.
What more you can get with WhatsApp APK?
This App uses your phone's Internet connection (2G/3G/4G/EDGE or Wi-Fi, as available) to let you call and message to your friends, loved ones and family, for that you don't have to pay any charges for every call or message. Moreover, there is no subscription fee to use WhatsApp.
By using this App you can easily send and receive documents, videos, photos, and Voice Messages. These are known as multimedia messages.
You can easily send videos, photos, documents and other stuff up to 100 MB on WhatsApp at super fast speed.
With WhatsApp calling you can call your friends and family without any charges, even they are abroad. No extra charge to send WhatsApp messages internationally. Chat with your family and friends throughout the world without paying international SMS charges.
WhatsApp provides you group chat. Enjoy group chats with your family or friends. So you can easily stay in touch with your friends or family and your contacts.
You can make a group of up to 256 people and can share photos, videos and send them messages at a time.
Send funny stickers, emojis, reactions and more with WhatsApp.
By using WhatsApp WEB, You can also send and receive messages right from your computer's browser. It does not need any username or PIN. The App works with your phone number, just like SMS, and integrates effortlessly with your phone's present address book.
You are always logged in with this App; so you don't slip messages. No more confusion about whether you're logged in or logged out.
WhatsApp quickly connects with your contacts. For that, your address book is used to rapidly and easily connect you with your contacts who have this App so there's no need to add hard-to-remember usernames.
WhatsApp works for you, Even if you turn off your phone or miss your notifications, it will save your current messages until the next time you use the app.
The unique usage of the App is, you can share your location, email chat history, exchange contacts, broadcast messages to more than one contact at a time, set custom wallpapers and notification sounds, and much more!
Download the latest version and feature-rich APK file of WhatsApp Messenger from below given link for free. Install the app on your android device or smartphones and start saying hello to your friends and family for free throughout the world.
This useful and must have application is offered by WhatsApp Inc and it requires Android 4.0.3 and up.
You are just a click away to download the latest APK.
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"timestamp": "2019-04-24T12:49:10",
"url": "https://www.apksfile.com/2016/03/whatsapp-latest-version-apk-free-for-android.html",
"language": "en",
"source": "c4"
}
|
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At the opening of the thinkport VIENNA, I had the opportunity to drive and test electric cargo-bikes. Such bikes are not just fun to drive around, they are furthermore a promising alternative for last-mile distribution in urban city centers. With a focus on restaurant deliveries, a simulation and optimization-based decision support system was developed in recent work to facilitate sustainable city logistics. It considers urban consolidation points to transship goods as well as deliveries of cooked meals by cargo-bikes and cars.
The following problem setting was considered: A logistics provider performs the delivery of food products for multiple competing restaurant operators. All deliveries to customers are performed by cargo bikes within a guaranteed delivery duration, while motorized vehicles can be used to bring goods closer to the demand area. Therefore, multiple consolidations points are operated, where goods are transshipped from cars to cargo-bikes. Consequently, long trips from the periphery of the city are performed by cars, while the last-mile distribution in the city center is done by cargo-bikes, which are less impacted by traffic conditions and parking restrictions. The objective is to both reduce delays and minimize travel distance.
The developed decision support system enables one, among others, to investigate the impact of operating consolidation points as well as to study how the guaranteed delivery duration influences travel distances and delays. Therefore, various uncertainties are considered within the simulation such as random ordering patterns of customers, who are located throughout the city. Furthermore, as cargo-bikes are often operated by freelancers, their availability varies over time within the simulation framework.
Results highlight that for successful cargo-bike operations, guaranteeing a sufficient number of freelancers is of importance. Furthermore, operating consolidation points to enable the transhipment of goods allows one to substantially shorten delivery times. By the developement of a computer-aided decision support system, specific problem settings can be investigated and tested in a flexible and risk free manner. This enables one to design real-world implementation to facilitate sustainable and efficient last-mile distribution.
Consequently, driving cargo-bikes is not just a lot of fun, it can also help to improve urban food deliveries and create a wide range of business opportunities.
Christian Fikar is a post-doctoral researcher at the Institute for Production Management at Vienna University of Economics and Business (WU). His research fields include logistics, supply chain management and related decision support systems to investigate and optimize delivery processes, particularly for humanitarian and food logistics operations.
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Parkinson’s disease happens when there is a problem with certain nerve cells in the brain. This disease affects the way you move because of inadequate production of dopamine, which is an important chemical that sends signals to the part of the brain that controls movement. Parkinson’s is a progressive disease whose symptoms take few years to surface.
Parkinson’s is an illness that affects the central nervous system with a direct blow on the brain, and spinal cord and usually only affects adults. More specifically, this disease damages a group of nerve cells in the deepest part of the brain called the Basal Ganglia. There are quiet a few reasons leading to Parkinson’s disease, including aging and poisons in the environment. To cure Parkinson’s disease, stem cell treatment is highly popular.
These nerve cells make and use a brain chemical called dopamine to send messages to other parts of the brain to coordinate body movements. When someone suffers from Parkinson’s disease, the dopamine levels are low. So, the body doesn’t get the right messages required to move normally.
About 1 million people in the United States alone have Parkinson’s, and both men and women can be affected by it. It usually affects the elderly population someone older than 50 and it becomes common as people get older.
Many people wonder if you’re more likely to inherit the Parkinson’s disease due to hereditary or not. The role that heredity plays isn’t completely understood, however, if someone has a close relative with Parkinson’s the chances of developing the disease becomes very high. But Parkinson’s disease is not transmittable. You can’t get it by simply being around someone who has it. An effective Parkinson’s disease stem cell treatment in Delhi, India that StemCellCareIndia offers can prove to be a boon for you.
Tremor, which essentially means shaking or trembling. Tremor may affect your hands, arms, or legs.
The symptoms of Parkinson’s disease include tremors or trembling (shaking hands are often the most telltale signs of Parkinson’s, including difficulty in maintaining balance and coordination; trouble standing or walking; stiffness; and general loss in swiftness.
Over the years, a person with Parkinson’s may have trouble smiling, talking, or swallowing. Their faces may appear flat and expression less, but people with Parkinson’s have feelings – even though their faces don’t always show it. Sometimes people with the disease can have trouble with thinking and remembering, too. Stem cell treatment for Parkinson’s is quiet popular and effective.
Because of problems with balance, some people with Parkinson’s frequently loose balance and fall, which can result in broken bones. Some people with Parkinson’s may also feel sad or depressed and lose interest in the things they used to do.
The symptoms of Parkinson’s disease appear gradually and get worse over time. But because Parkinson’s disease usually develops slowly, most people who suffer from it can live a long and relatively healthy life. Parkinson’ disease stem cell treatment in India is popular and trusted.
Blood tests may be done to check for abnormal thyroid hormone levels or liver damage.
An imaging test (such as a CT scan or an MRI) may be used to check for signs of a stroke or brain tumor.
PET, sometimes may detect low levels of dopamine in the brain, a key feature of Parkinson’s. But PET scanning isn’t commonly used to evaluate Parkinson’s because it’s costly, not available in many hospitals, and only used experimentally.
Latest researches have revealed that Umbilical Cord Mesenchymal Stem Cells can differentiate into nerve cells, neovascularise (formation of blood vessels) immunomodulate when injected into the affected area, thereby improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed at managing only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.
In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating MS. WJ-MSCs offers cost-effective and pain-free collection method that may be cryogenic ally stored, and is extremely favorable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of the following.
Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for any further process of the procedure.
Source Extraction: With guidance and approval from experienced physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine the tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well-being. The only limitation of allogenic stem cell treatment is that this procedure carries the risk of developing Graft vs host disease GVHD, wherein the patient’s body rejects the donor stem cells. Human leukocyte antigens (HLA) can help minimize the risk. In this procedure, the HLA of the patient and donor are matched as closely as possible.
Parkinson’s disease stem cell Treatment Aftercare: The patients will be asked to visit the doctors for evaluation. You will be provided counseling for speedy recovery.
What causes Parkinson’s Disease?Parkinson’s is caused by progressive deterioration of neurons within the brain region referred to as nucleus Niger. Neurons once signals usually they manufacture a form of neurochemical referred to as monoamine neurotransmitter that controls sleek and balanced muscular movement. A down regulation of monoamine neurotransmitter might end in associate degree abnormal nerve functioning resulting in loss of ability and dominant body movements.
What are the dangerous factors related to the disease?Although the basic cause continues to be unknown, the disorder is principally related to the genetic disease.
What are the signs and symptoms of Parkinson’s’ Disease?Involuntary tremors, shaking voice, unrest head, tremors that worsen throughout emotional stress and reduce with rest, problem with balance, muscular rigidity, changes in walking pattern and posture etc.
How is it conventionally diagnosed & treated?Conventionally drug medical aid and therapeutic rehabilitation approach were applied as a treatment for Parkinson’s, but the treatment failed to convince being effective in reversing the injury. In addition, long run use of hormone drugs might be terribly fatal, hospitable alternative unwanted facet effects. Parkinson’s stem cell treatment hospitals suffice and provide stem cell treatment for this particular disease.
How will stem cells be helpful to treat?Undifferentiated adult autologous stem cells are changeable and might metamorph into unnamable range of cells as per the necessity. This outstanding property of stem cells is utilized for treating the spread of diseases. These cells are isolated from the foremost potent sources of our own body referred to as animal tissue and Bone Marrow. Upon implanting into the body, these cells start to speedily multiply to revive broken neurons, regularize the assembly of neurotransmitters together with monoamine neurotransmitter to retain the brain’s traditional performance back.
Additionally to somatic cell medical aid, a stimulation medical aid also can be applied, whereby the organ is excited to multiply resident stem cells and secrete growth factors to make microenvironment. The stem cell treatment for Parkinson’s can act as a booster to market regeneration.
Why is stem cells treatment higher than standard treatment approach?Conventional treatment approach is extremely invasive related to the several facet effects. Though stem cells naturally heal the body from injury and regenerate the lost neurons to enhance the impaired functions. In addition, since body’s own cells are used for repairing, the complete treatment is minimally invasive with none facet effects, which is why Parkinson’s disease stem cell treatment in Delhi has gained popularity.
7. How do I do know if I’m the proper candidate for the stem cells treatment?
There are several necessary problems that need to be addressed before choosing the treatment, which might provide satisfactory answer solely by consultants. Thus, it’s forever sensible to consult, and choose the proper stem cells treatment pattern.
I am Janet and until few months, was a sufferer of Parkinson’s disease. My life was nothing less than hell. Then, I approached StemCellCareIndia and guess what, all my miseries got cured!
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Codub Consulting work with our customer to provide the levels of support that they need. We will provide a priority web based System Administration support system to ensure that any inquiries are dealt within the fastest way possible. We employ a dedicated and knowledgeable Technical Support Team available to resolve issues and assist with questions quickly and easily.
Normal business hours are [9:00 am] to [5:00 pm] [Monday through Friday] UK time but can arrange additional cover outside these times. Codub Consulting provide and maintain an electronic system (Ticket System). This enables our Customers to raise requests via a portal at support.codubconsulting.com. Once a ticket is created an email will be sent to our technical team immediately and you the customer should also receive an acknowledgement email. Also, an email will be sent to you as the ticket is updated till completion. The response time will be agreed with you and defined in your Service Level Agreement (SLA).
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but now front edge of hood will not come down.Both bumpers are off underneath so thats not the problem. Tryed everything. If i loosen up both bolts on the side of the hingge and tilt hood down in front the back sticks up over 1/2 inch. Possible i have to open slots up even more than from the factory on my hood hinges???
Helpfull hint, after studying the problem i took rear mounting bolt out of the hinges, that had a very large washer behind the head of the bolt. I simply replaced them with a bolt without a washer and hood now fits 80% better.
Now for a little tweaking!!! Washer was hitting the hinge frame.
All times are GMT -3. The time now is 07:49PM.
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Wastegates Performance Racing Products for International Sales from SSAutochrome Inc.
Included in the kit are a 50mm BOV (Black) and a 60mm wastegate. Both come with complete accessories as shown in images.
Both of the BOV and the wastegate are available in BLACK, BLUE, SILVER and RED colors. Please let us know your choice of color by leaving a message when bidding on this listing. Black will be sent if not otherwise specified.
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"url": "http://ssautochrome.com/level.itml/icOid/1544",
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Home›Yoga Tips›What are some of the recommended yoga positions for beginners?
What are some of the recommended yoga positions for beginners?
I do not pretend to be a Yoga professional like Adriene and nothing better than her videos to introduce you to the different postures of Yoga.
There must be hundreds, but here are the ones that do me the most good and which for me are basic to master. Namaste girls!
This posture, also called Surya Namaskar, is best done in the morning and in the evening, in front of the sun, because it represents a source of life in yoga culture. It also usually serves as a warm up before a full session. It also helps strengthen your muscles and promote weight loss, not bad right?
Put your hands and forearms on the ground, your elbows along the body.
Your legs and feet should be stretched and joined.
Stand slowly while inspiring and keeping the body members in the basic posture.
Look far ahead and then throw your head back while arching.
Return to departure by exhaling.
This posture affects the functioning of the kidneys and promotes digestion.
Sit down, bend one leg with your foot against your buttock, then bend your other leg, this time placing your foot against your knee. You follow ?
Put one hand on it, then the other hand on the ground.
Then swivel the hips so your shoulders are in line with your legs.
Like any yoga posture, your back should be straight.
Look behind you while breathing calmly.
Inhale while raising your arms straight to the sky, in line with your shoulders.
While swiveling your hips, place your right hand on the opposite foot. Your gaze is directed towards your left hand always raised towards the sky.
Breathe then return to the center and start again with the left hand.
This posture refines the size and eliminates fat.
Come on, we complicate a little!
Lie on your back, hands flat along your body.
Straighten your legs vertically and hop, raise your pelvis off the ground.
Your legs in the vertical should gradually tilt so that your feet touch the ground behind your head.
Hold posture while breathing slowly. No more than 15min anyway!
Gently return to the starting position and blow.
This posture acts on the spine and blood circulation. It also promotes the digestive system and limits fat deposits.
Bring your hands to your chest, inhale while raising your hands to the sky.
Exhale and return to departure.
Repeat the posture by bending this time one leg, put the foot against the thigh or groin.
Try to hold the position as long as possible by closing your eyes.
This posture helps to work the physical balance and concentration.
With the lotus, we relax! To finish a session well, you must first refocus and breathe.
Sit cross-legged. The exercise should be done while inhaling and exhaling slowly.
Fold your right leg by placing your foot on your left thigh and vice versa for your left leg.
Rock your pelvis forward and stand straight (imagine a thread hanging on the top of your skull, it works pretty well). Your knees should be closest to the ground.
On an inspiration, join both hands in front of your solar plexus (your chest) and exhale.
Then put your mans on your knees, palms apart, to the sky.
Perform about fifteen breaths while focusing on the rhythm of it.
Relaxation settles as you go, you are ready to face life with serenity.
READ What are the principles of mindfulness meditation?
On an expiration, lean forward fully. The head should touch the ground (finally as far as possible of course).
Then, gently go back on an inspiration.
During this exercise, the back is always straight and the buttocks on the ground.
Ideal for working lumbar and promote your digestive system.
What yoga exercise reduces hair fall?
How did practicing mindfulness help you in your life?
To drink or not to drink water during a yoga practice?
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"The demand for intelligence drives innovations and this is where we see the integration of Artificial Intelligence (AI) in Robots!"
one’s financial assistant to aid in decision making. With the successful demonstration of the efficacy of these robots, the emphasis is now on infusing Intelligence capabilities to allow robots to be fully autonomous in their functioning and decision-making. The demand for intelligence drives innovations and this is where we see the integration of Artificial Intelligence (AI) in Robots!
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{
"timestamp": "2019-04-22T14:26:52",
"url": "https://robotics.apacciooutlook.com/cxoinsights/artificial-intelligence-programmed-robots-will-they-complement-nwid-3588.html",
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What's your décor style? Our voluminous wallpaper collections include styles to please any taste! From country-chic to clean and modern, vintage Victorian and traditional elegance, or perhaps just a fine wallpaper border to define a space, you will find compelling designs to complement your style. View below some of our favorites from Contemporary to tropical.
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In our program Dr. Georgy discusses each of the following topics in his 4 hour video presentations. Additionally, each of the topics below are covered in our interactive test questions, so you will get ample practice with every possible topic covered on the ISEE and SSAT.
We are very happy with the course and videos that we bought from the website.
We actually used the account for our son (who is upper level) and our daughter (who is lower level) so it was a real bargain for us. The cost was the same as sending the kids to a tutor for just one lesson.
I thought I'd send a quick email that you can use on your site if you want to.
This system is excellent, full of practice questions and even videos with actual tutors.
If anyone is on the fence they should really consider buying it, it is great value.
We spent about $2000 on tutoring for our boy before the exam, which was a lot of money.
Just came across your website and bought the package, so much great information. I'm sure he will get a lot of help from this and it is so cheap in comparison.
After 3 months of spending $85/hour for a private tutor, my son was still not ready.
We are so glad that we bought your program. My son enjoyed doing the practice questions and watched the videos instead of TV. He really felt confident when he tested. Thank you.
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On Teclast.com there is a new image with the date 2.29 and Four years unique if my google translation is any good. Does this mean on the 29th will we see some new tablets announced? With Cube’s i9 Intel Skylake Core M3 already out in China, one can only assume Teclast must have their own Core M model up their sleeves. Maybe a new Atom Z8X50 powered tablet since Z8500 supplies must be low now and Intel should have the refreshed Cherry Trail ready for next month.
Echo from Shenzhen OKQI Electronics Mall also told me today that the Teclast X98 Plus Dual OS is coming in March with 3G support. Thanks Echo for the tip.
There where bay trail models…But only this in 2016.
i whish 4g whith band 1700 for Sudamerica.
I think it will be a 8300 with 3g support… nothing more.
I also think this, shame. But maybe too early for their Core M3 tablet.
Alcatel at Mobile World Congress 2016 has announced ALCATEL PLUS 10 a 10′ windows 10 tablet with 8350 intel soc.
Specs are not so good but 8350 intrigues me.
I think it became the X98 Plus 3G. 4G modems are still too expensive I recall Teclast saying to price them for the market they aim for – low end / budget.
X98 Plus with 3G sounds cool!
I hope 4g with 800mhz support not only 3g.
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Home remedies #1: A high-potency multivitamin and multimineral daily.
Beta-carotene. Take 25,000 international units daily.
Vitamin-B complex. Take a supplement containing 100 milligrams of most of the major B vitamins. Also take an additional 50 milligrams of biotin daily.
Vitamin C. Take 1,000 milligrams twice a day.
Vitamin E. Take 400 international units daily, with 100 micrograms of selenium to aid its absorption.
Iron. Take 50 milligrams daily.
Zinc. Take 50 milligrams daily, with food and with 2 milligrams of copper.
Silica. Take 250 milligrams twice a day.
Free-form amino acid complex. Take 2 grams (2,000 milligrams) three times a day, before or after meals.
In addition to correcting any vitamin deficiencies, women whose hair loss is due to physical trauma, crash diets, or heavy menstrual periods can benefit from supplementation with a high-potency multivitamin and 50 milligrams of iron, together with 1,000 milligrams of vitamin C to boost iron absorption.
Thinning hair can be a sign of poor nutrient absorption, which in turn can be due to an insufficient supply of stomach acid or bacterial overgrowth in the stomach. Taking one tablet of hydrochloric acid (HC1) and one digestive enzyme capsule after starting each meal, plus 1/2 teaspoon of powdered acidophilus dissolved in 2 ounces of water twice a day between meals, can aid in nutrient absorption.
• Inositol with choline has been found to stimulate hair regrowth in some people with nonscarring alopecia. Take 200 milligrams twice a day.
Saw palmetto is the first choice of many herbalists for male pattern bald ness. Saw palmetto blocks the formation of dihydrotestosterone, a hormone thought to kill off hair follicles and lead to androgenic alopecia. Take 160 milligrams twice a day.
DS Some people have had success using aloe. It is suggested that you apply the gel to the scalp every night before bed, and also take 2 tablespoons of aloe juice orally each day.
Arnica can be applied to the scalp twice a day in the form of a cream, ointment, or hair rinse made from arnica tincture diluted with warm water. Arnica increases local blood circulation, and may thereby help promote hair growth.
Jojoba oil may help with hair loss when applied to the scalp.
Emu oil, or kalaya oil, is recommended as a moisturizer and hair-root stimulant to promote hair growth.
Licorice also contains a chemical that prevents testosterone from being changed to dihydrotestosterone. You can add licorice tincture or extract to your favorite shampoo.
Rosemary has long been believed to keep hair healthy and lush. Add one part rosemary oil to two parts almond oil and massage the mixture into your scalp for twenty minutes a day.
Sage has been believed for centuries to help prevent hair loss. Like licorice, sage extract can be added to your favorite shampoo. Or you can use double-strength sage tea daily as a hair rinse to encourage hair growth.
Safflower is considered to be a good vasodilator. Massage your scalp with safflower oil for twenty minutes a day to increase local blood flow and stimulate hair growth.Jojoba oil may help with hair loss when applied to the scalp.
Essential oils may be the rescue you’re looking for. Using them as part of your hair care routine can breathe new life and luster into your hair. Essential oils also infuse your hair with a burst of fragrance.
For centuries, people have used essential oils for a variety of medicinal and cosmetic purposes. The beauty industry eventually caught on, marketing luxurious aromatherapy shampoos, serums, and other hair care products -- with equally luxurious prices.
Today, you don't have to spend a fortune for essential oils. Many health food stores sell inexpensive versions. Here are some essential oils that experts recommend for dry hair.
Almond oil soothes and moisturizes the scalp.
You only need a few drops of an essential oil -- mix one or more types in a shampoo or conditioner. Or mix the drops into 2 ounces of a "carrier" oil, such as olive or jojoba. Experts suggest these combos.
After you apply the oil mixture, cover your head in a towel or shower cap.
You can either wash out the treatment after 30 minutes or leave it on overnight and shampoo in the morning.
Remember to wash out oils completely. When you leave them in too long, they weigh down hair, leaving it limp and oily.
If you apply some essential oils directly to your scalp, they may cause irritation. Diluting them is the answer. Read label instructions for how to dilute oils, and never use them in higher-than-recommended amounts.
If you're allergic to plants such as ragweed, test the oil on a small area of your skin or hair to see if you have a reaction.
A lysine deficiency may cause hair loss. The hair across your scalp may appear sparse or your hair may break easily while you are washing or brushing it. Excessive hair loss may be embarrassing to certain people; however, normal hair growth typically returns once your lysine levels return to normal.
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Last weekend Shawn and I were discussing where we would put all of Henry's new toys after Christmas time. Spoiled baby. My living room floor looks like a day care.
He has a decent sized room with a huge closet but we don't seem to play in there as often as we do in other areas of the house. We have a cozy little house with plenty of room for us right now, but I'd kill for an extra playroom. We have an extra bedroom but I think it would be best to leave it as our office/guestroom for now so it's free for baby #2- hopefully it will be needed sooner than later;) So that leaves our formal dining room! We use it maybe 2x a year so why waste that glorious extra square footage!?
The room is right off the entry and has a large arched entry. I'd love to be able to put up some kind of door- to keep the kids (and noise) contained. A couple of doors on a barn door track may do the trick.
It would have to be mounted on the inside of the room but I think it could totally work!
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We're about to alleviate your SEO fears with these small business SEO basics. These tips will by no means make you an expert, but it's a great place to start!
What comes to mind whenever you hear Search Engine Optimization? Difficult. I know!
I had the same impression when I first heard about it, but remember that first impressions aren't always correct. Small business SEO isn't as difficult as it may appear.
"Search engine optimization (SEO) is the process of optimizing your online content so that a search engine likes to show it as a top result for searches of a certain keyword."
SEO is indeed a powerful modern marketing strategy that can catapult a small business to success. However, SEO doesn't have to be difficult.
As long as you know what you need to focus on you'll make significant progress with your small business SEO strategy.
You have the option to do SEO for your small business yourself. My goal in this article is to give you some tools and tips if you choose to go this route.
You may choose to hire a SEO expert. Before you go this route, it's really important you are prepared to ask the right questions to properly qualify any SEO expert.
SEO puts your small business in the "seen zone" of the internet world.
SEO is more of a strategy on how to get the word out about who you are and what you do. Building a website isn't enough anymore for the world to notice your small business.
SEO is a great investment.
It does require time, money, and patience to be successful and it will be an ongoing project for your business. But, it's kind of like the "gift that keeps on giving" because the return on investment will keep coming in as long as you do it right. SEO is not difficult to learn. If you don't have the luxury of time, hire a consultant or an agency to do the job for you.
SEO can help boost sales.
If coupled with proper research, it can bring more visitors to your website which translates to more profit. More profit means infinite opportunity for your small business.
When done correctly, SEO doesn't have to break the bank. It can be cost-effective, very targeted and it can be applied locally, nationally or even internationally.
The results you get from SEO are very trackable.
Google Analytics is a great tool that will give you access to these results. It can tell how many potential customers are coming to your website, what keywords they use to find you, and many more factors that will help you determine the progress and ROI of your SEO efforts.
SEO can put your website on top of the search engines like Google, Yahoo, and Bing. SEO, when done properly, will tell people that your business is reputable and trustworthy.
Paid tools can be really helpful and make the process quicker if you have the budget. The Definitive Guide below has some great recommendations for paid keyword research tools.
Once you've got great keywords to optimize for SEO you need to optimize the page you want to rank by optimizing specific areas of the web page. This is called on-page SEO. Here is some of the common terminology of on-page SEO with some quick tips.
Title Tags are an HTML element that specifies the title of a web page. Title tags should be 60 characters or less and should contain your main focus keyword. If possible, it's great to have the keyword start the title tag but it's not absolutely necessary.
Meta Description is the 160 character or less snippet used to summarize a web page’s content. Make it descriptive of the content, but don't stuff your keyword all over the place. Try using synonyms or variations of your main focus keyword.
Heading Tags are tags to let search engines know about the headings on a page. They have a top-down hierarchy from H1 to H6. Your H1 heading tag may be the same as your Title tag or a slight variation of it and should have your main focus keyword in it. Your subheadings should be H2 or H3 heading tags.
Keyword Density tells you how often keywords or keyword phrases appear in a text in relation to the total number of words a webpage contains. You should try to use your main focus keyword a few times in the text, but keep it natural.
Schema markup is a code that you put on your website to help search engines like Google to return more informative results for users. This is pretty advanced and I would recommend you enlist the help of a SEO expert before diving into this. Schema is still relatively new, but it is an SEO ranking factor and will help your SEO efforts if you use it.
Backlinko wrote a great article about best practices for On-Page SEO that will give you some more details on all of this. I'd highly recommend checking it out.
Content marketing simply means producing articles, blogs, images, and videos consistently to stir interest from your audience and maintain existing relationships.
Content marketing is essential for any successful, long-term SEO strategy today. You must have content as part of your SEO strategy, otherwise, any results you see will be fleeting.
Your content should offer tons of value.
Your content should be specific to your target market.
You should have an effective content distribution strategy.
If you have to choose between short, frequent content and longer, in-depth content I would focus on longer, in-depth content.
Don't be afraid to try different content formats.
Always personalize content for users.
Ask for feedback to improve content.
Target long tail keywords to maximize the effectiveness of your content for SEO.
For some additional resources check out this article for effective content marketing tactics.
Backlinks are achieved when other websites link to your website from their own page. In general, the more sites that link to your site the higher you will rank in search engines like Google.
Write guest articles on reputable websites in your niche.
Interview people within your industry and include their thoughts on your blog. Publish the post that includes them, then ask them to share the post on their social network. Ask if they can also link back to your site.
Check your competitor’s backlinks and if possible replicate the best backlinks from them.
Find broken links on other sites that are relevant to a blog article you wrote. Email the site owner letting them know about the broken link with a link to your article as a replacement.
Want even more ideas for getting backlinks? Here are some additional ideas for getting backlinks.
SEO is constantly evolving, but it doesn't have to be difficult. Focus by starting on the small business SEO basics we've provided you here and I'm sure you will see improvement in your website's rankings.
Track your results and make tweaks as necessary...even the best in SEO are learning new things every day.
When you are ready for more detailed info, we put together a list of the best SEO articles of 2017.
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Silver Purple Wedding Invitation Template Kit Suite Inside Invitations Plan 49 is one of pictures thet are related with the picture before in the collection gallery. If you would like to see the Silver Purple Wedding Invitation Template Kit Suite Inside Invitations Plan 49 in High Resolution [HD Resolution] version, please press the right click on picures/image then choose "Save as Image" option, and done. You will get Silver Purple Wedding Invitation Template Kit Suite Inside Invitations Plan 49 pictures that you want. The exactly dimension of Silver Purple Wedding Invitation Template Kit Suite Inside Invitations Plan 49 was 900x771 pixels. You can also look for some pictures by collection on below this picture. Find the other picture or article about Purple Wedding Invitations here. We hope it can help you to get information of the picture.
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The search for a 12-year-old girl swept out to sea at New Hampshire’s Hampton Beach ended today with the grim discovery of her body, in waist-deep in water just south of where she disappeared.
The body of Nayelin Encarnacion, of Lawrence, Mass., was located just after 1 p.m., about 100 yards south of where she was last seen struggling against the current.
She and her 20-year-old brother, Walter Maldonado, were swimming about 75 yards off-shore just before 8 p.m. Monday when both began struggling to get back to shore, Seacoastonline.com reported.
A bystander heard their cries for help and was able to guide Madonado back to shore, but Nayelin disappeared from sight. The water temperature at the time was 55 degrees, officials say.
Police received their first reports of swimmers in distress at the popular beach at 7:50 p.m. An intensive search and rescue effort involving numerous boats and a helicopter from the Coast Guard’s Cape Cod station was under way when her body was located. The New Hampshire medical examiner was called to the scene.
Lifeguards, who had been on-duty at the beach on Memorial Day until 5 p.m., were called back to assist in the search. They were told to stop their search efforts at 9:30 p.m. Monday because of darkness and the chilly water temperature, according to Seacoastonline.com.
Nayelin and her brother were with friends on a one-day outing to the beach when it happened.
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America owes $6 trillion to China, our sprawling military complex often appears helpless against disparate threats abroad, and the War on Terror has stripped us of the moral high ground. Washington is paralyzed by bitter partisanship, our children are falling behind their international peers, and our middle class is no longer the world’s most affluent. But we’ve been warned about America’s decline before. Remember Sputnik? Yes, times are tough, but America is recovering from the Great Recession faster than almost any other advanced country, an energy boom could add billions to the GDP, we’re still a leader in technological innovation, and our military strength and geopolitical advantages remain unrivaled. Are our best days behind us, or should the world still bet on America?
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Why Having Kids Is Awesome!
Having children is one of the biggest decisions you will ever make. Being a parent is exciting, fun and interesting but also knackering, hard work and never ending. There are many brilliant reasons to have children and here are a few reasons why I think having kids is awesome!
Kids have a lot of toys. Noisy toys, soft toys, pull along toys….I have really enjoyed buying toys for my girls but I’ve also used it as a bit of an excuse.
When I was a child, I had a Big Yellow Teapot (remember them?) I loved playing with it and it’s a real throwback to my childhood. When the children came along it was the perfect excuse to get hold of another Big Yellow Teapot. Purely for The Toddler to play with of course.
It’s not just me either. I found a train set on Facebook the other day which I thought the girls would enjoy. When I showed my husband, his face lit up and he spent the rest of the evening setting up the most elaborate train track you’ve ever seen. He didn’t even notice when The Toddler wandered off to play with something else.
Your boring workmate has invited you to his latest “bring a fact” party and you can’t think of a polite way to decline. Ah hah! You have kids now. They are the perfect excuse. From suffering from various coughs and colds to being let down last minute by childcare, you have the ultimate “get out of jail” free card. Just remember that if you use the excuse that you had to stay home because the kids are sick, don’t then post photos on Facebook about your fun trip to the zoo that day!
Children are really gullible. You could poetically say they are innocent and trusting and they believe in magic but no, let’s call a spade a spade, they are flipping gullible! They will believe ANYTHING! This is great fun as you can literally tell them anything and they will believe you. Oh, the possibilities…..
I took the Toddler trick or treating this Halloween. She’s only 2 but she soon realised all she had to do was knock on the door and say “twick or teat” and she was given sweeties. Unfortunately, quite a few of them were unsuitable for her as she’s just too young. As any responsible parent should do, I went through her bag and “got rid of” all the sweets she couldn’t have. I put them to one side in a box with the idea of disposing of them later (read that as scoffing the lot). Annoyingly my husband found the box and “got rid of them” for me. Thanks, hubby!
I love Christmas but it is made extra special when you are experiencing it through the eyes of your children. The Toddler is already getting excited over all the “pretty lights” that are popping up in shop windows. I’m desperate to put up our tree but I will hold off until December. At her age she doesn’t even know about the present part, she’s just getting excited over the decorations! She is going to love it this year. I can’t wait!
What do you think is the best thing about having kids?
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Come and help us celebrate in style as we celebrate six fun years.
Huge discounts on all apparel stock.
Giant goodie bags & giveawys all afternoon!
honeyeater. turns six! at honeyeater.
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I am writing to this mailing list to inquire some more information about the MD5-crypt implementation in John the Ripper. I am currently writing my master thesis which is titled 'On the Security of Password Hashing Schemes regarding Advances in Graphic Processing Units' and I am doing research to see if password hashing schemes like MD5-crypt can be implemented efficiently on GPU hardware to see if the security of those schemes is still preserved when performing exhaustive search on the password input space.
I used Poul-Hennig Kamp's code to produce a CUDA compatible implementation of MD5-crypt that can perform exhaustive search on GPU's (which already performs 30 times faster than an equally priced CPU). However, when I tried to unravel the FreeBSD MD5 implementation in John the Ripper (more specifically, 'void MD5_std_crypt()' in MD5_std.c), I could not determine why you only need 500 iterations (instead of 1000) to calculate the final hash. I searched for some design/implementation documents/comments in this mailing list, but without success. Can somebody explain this to me?
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Don’t worry if you don’t understand a word he says – it’s still hilarious to watch this Swiss member of parliament try to make it through his very serious speech without laughing.
Shouldn’t your country have a happiness minister?
The UAE’s minister for happiness opens the conference.
I am back from Dubai where I spent 3 days at the World Government Summit along with 4,000 other delegates.
One theme running through the entire event was how government policies can further the happiness of citizens. I was invited to participate as an expert in happiness at work.
And the event was REALLY fascinating. They had many of the biggest names in the field come and speak, including Ed Diener, Sir Richard Layard, Jeffrey Sachs and the prime minister of Bhutan where they have been focusing the country’s development on happiness for the last 15-20 years.
The closing speakers were the economist Joseph Stiglitz and Elon Musk.
I am hugely impressed with the scope of the event and also with the consistent focus on how governments can focus on the wellbeing of their citizens, rather than just on economic growth. I think this is a fascinating vision for the future of public policy making.
So shouldn’t your country have a happiness minister? I wish mine did!
Job lock vs. flexicurity. What would you prefer?
I rarely go into politics or public policy on this blog, but I’m going to make an exeption today.
I’ve been following the US debate on health care pretty closely and the biggest issue currently in play is whether or not the US government should offer health care in addition to the private insurance companies.
Millions of Americans are in what’s called “job lock.” They can’t leave their jobs because they feel they can’t get the same health insurance benefits on their own or at the next job.
In other words, you may hate your job but if you quit you and your family no longer have health insurance. This article looks at job lock in detail.
In Denmark on the other hand, we have pretty much the exact opposite: Health care is public and paid for through our taxes. In addition, Denmark has a unique labor market approach called flexicurity.
Flexicurity means that on one hand it’s easy for companies to fire employees but on the other hand, you get very generous unemployment benefits, ie. 90% of your salary.
The drawback to this system is obvious: Very high taxes.
The advantages are many, though. First of all, the Danish economy has been doing very well. Even now, during the financial crisis, we’re doing better than most of Europe and unemployment is still below 5%.
From a standpoint of happiness at work, there is no doubt that the Danish system is best. When it’s easy and safe to quit a job there is much less risk in leaving a job you hate. Even if you choose not to quit, just knowing that you could makes things more bearable. Hating you job AND knowing that you can’t quit makes everything worse.
Even the fact that it’s easy to fire people increases happiness at work. Seriously! It means that companies can fire employees who don’t perform well or who don’t fit in.
In countries with very strong labour protection laws, it can be almost impossible to fire anyone – meaning that underperforming employees stay in their jobs and everyone else has to pick up the slack. Also, remember that unhappiness at work is highly contagious, so one unhappy employee can easily drag down the whole department.
So in my opinion (and I am NOT an economist, so take this with a grain of salt) the flexicurity model makes Danes happier at work – and as I’ve previously mentioned happy workplaces are more productive, innovative and profitable.
The American model on the other hand, makes people less happy at work and thus decreases productivity.
What do you think? Have you ever experienced job lock? What advantages or drawbacks can you see to the US or the Danish model?
The 10 worst excuses for not quitting a crappy job.
Top 10 signs you’re unhappy at work.
Steve Forbes was in Denmark this week on a European tour, meeting with political and business leaders. His main message was that while Denmark has arguably the strongest economy in Europe right now, the high danish taxes are limiting our economic growth.
And danish taxes are very high: The highest tax bracket kicks in after only 40.000$ earned, and you pay 60% taxes on everything you earn over that. This money is used to finance a very high level of public services, including free health care, schools and universities for everybody.
The high tax level also finances what is called the danish flex-security model: In Denmark it’s relatively easy to fire employess (flexibility) but unemployed danes enjoy great benefits (security). Compare this to Sweden where it’s very, very difficult to lay employees off because the unions have enormous influence or to the US where unemployment benefits are not as generous.
I think he’s wrong, wrong, wrong, and I’ll tell you why!
Politics has become a game of meaningless, mindless battles, conducted by unscrupulous methods and people, designed to transform even the most serious policy debates into sport.
I’m speaking at the Reboot conference in Copenhagen on june 1-2. My topic is how we can reboot democracy, which is absolutely necessary because I believe politics is broken.
Leading up to the conference, I was interviewed by podcaster extraordinaire Nicole Simon. We had a great chat about politics, why people don’t care for it and what it would take to get us all involved in creating the future of the world (main keyword: It has to be fun!).
the official place of registration for Danish Businesses. In parallel the DCCA administers legislations regulating Businesses, amongst others the Companies Act and the Company Accounts Act.
Before you get too many images of a dusty, boring government agency rubberstamping it old-skool, I’ll have you know that they’re actually pretty with-it.
How can we know that? Because they made we are funky one of their core values. Yep, that’s right, a government agency that wants to be funky. This is great news, and a good sign that public work places can actually be very modern and fun to work at.
It’s time for us to take back politics. Let’s discuss how we can use existing web technologies to create a political process where you and I can contribute directly and regularly, instead of just voting every four years. Because politics is too important to leave to the politicians.
The internet, if kept open and accessible to all, is a tool we can use to reform our politics and create new democratic processes and institutions. By using the internet and building upon its open decentralized architecture, we can help give every person a voice and offer them a forum to participate in creating a healthy politics. The internet provides the tools to build bottom-up systems that are both globally interconnected and locally controlled.
I have a deep feeling, that introducing a new, bottom-up political process is the best way to solve many of todays problems, and the only way to really develop our societies. Let’s do it! I wrote about this previously here and here.
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At the end of June I sold some jewellery in my church Arts and Crafts show. I made a bunch of money, which was nice, and here's some photos of my displays. Not super professional, but whatever. I was under SO much pressure that week, it was RIDICULOUS. Exams, arts and crafts, birthday, music stuff, church strife, guests… it was crazy times. So I'm amazed I got anything in the show at all!
I used some empty picture frames to display my stuff, with fabric-covered cardboard to stick the pins in. It worked pretty well!
As well as selling earrings, necklaces and brooches, I made and sold hair bows. I made quite a few sets. They're actually really difficult to make, plus I kept getting fond of them. I made about 7 sets, but ended up keeping 3. They work well on bags and cardigans as well as on hair! I'm really getting into these kinds of accessories.
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A great read, and so important, on so many levels!
Aug 21, 2014 1 of 1 found this helpful.
Boost your confidence levels and watch your dreams become reality!
Awesome combo that you'll read again and again!
We counted 23 reviews for this product over the span of 195 days, an average of 0.1 reviews per day. If these reviews were created randomly, there would be a 99.9% chance that we would see 2 or fewer reviews on any given day.
7 of the 23 total reviews for this product are unverified purchases. This is within an acceptable range and it does not appear to be significantly affecting the overall rating for this product.
11 of the 23 reviewers have substantial overlapping product review history. This is within an acceptable range and it does not appear to be significantly affecting the overall rating for this product.
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At Larson Dental, we can provide patients with implant supported dentures to give them a dependable and durable alternative to dentures, dental bridges, and traditional dental implants. If you live in Salt Lake City, UT or the surrounding area, we encourage you to call (801) 290-6386 and schedule a consultation so we can examine you and determine if you are a good candidate for this procedure.
When it is time for the implant procedure, we will have you come back in and numb your gums and provide you with anesthesia. Typically, we will then place four small implants under your gum line. These implants will serve as anchors that your new set of teeth can attach to. Once they are firmly in place, we can snap in your dentures. These implants are an alternative to simply hoping your dentures stay in place or using adhesive to ensure they do. With implants to secure to, your teeth will not fall out, even if you are going on a run or eating pizza. For more information, call our Salt Lake City, UT dental office at 801-290-6386.
Check out what others are saying about our implant supported denture services on Yelp: Implant Supported Dentures Salt Lake City.
No, if you live in the Salt Lake City area, only certain dentists offer this type of prosthetic. We perform the procedure on a regular basis, and understand the clear benefit of providing patients with a durable set of replacement teeth.
For the most part, everyone can get the procedure. However, there are a few health factors to consider. We need to examine you to determine if you have any signs of gum disease or other infections that need to be corrected first. Simultaneously, there may be other health conditions that impact the procedure. Diabetics, for example, can receive implant supported dentures, but may need to wait for their blood sugar to be under control before we can begin. We can examine you in our Salt Lake City dental office and let you know if we anticipate any roadblocks.
No, when you visit our office, we will provide you with any necessary sedation. At Larson Dental, we understand that dental procedures can be intimidating, and we will take steps to ensure that you remain comfortable and relaxed during the appointment.
Traditional dentures are designed to come out every night. They remain in place by wrapping around your gums and creating a suction effect enhanced by denture paste. This can be messy, and if your dentures slip, it can be uncomfortable and inconvenient. With implant dentures, your dentures snap into position, secured in place by the implants themselves. Your new teeth will look natural and be entirely secure, adding further enjoyment to your daily life. To learn more about this procedure, call 801-290-6386. We will be happy to meet with you and discuss all your options.
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Our talented engineers devise innovative Boardroom audio visual solutions for your complex problems and business needs. Our engineers go beyond the stated manufacturer's claims and recommendations to get the best out of your equipment. They know each product’s limitations and how to troubleshoot any issues that may arise.
At JVN systems, we use advanced audio and video teleconferencing techniques to bring your callers and meetings to life. We can generate this experience even for clients who choose to work with less expensive video conferencing equipment that isn’t manufactured for advanced HD telepresence purposes. We can often find innovative video conference room solutions at a fraction of the cost of other conference room technology suppliers, and our clients appreciate all we do for them.
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Now I get it. Thank you, Harlan. In a world where we buy, buy, buy we writers are truly needed. I think we have somehow lost the ability to express the love we feel for our friends and family.
Perhaps we need to challenge ourselves to spend more time putting our love into words instead of dollars into silly gifts. But that takes time and thought and digging deep into our souls. That is the gift that is most dear, the one that money can’t buy. It is the gift of sharing our true self.
What one true gift can you give this year?
That is a beautiful gift Sadje.
So good! You said it exactly! Heartfelt words are more valuable than anything you can buy.
Thanks Jo and they sure do!
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A combined article, contributors Ruud Vos, Wim Das, Kees Otten, Roger Soupart and Cor van Gent.
Due to budget cuts the Open Days will be held every two years now.
In this overview we limit ourselves to a photographic impression, though we have a short story as well !
Not for nothing it is said: 'As finishing touch, God created the Dutch !' They show !
Beware... don't mess with this machine !
Another reason was the first landing of the C017 Globemaster from Papa, flown with entire Dutch crew !
On page two of this impression you can find a complete article about this exclusive Globemaster event !
.... ready to make it's demonstration for the public.
Oh... too much: Also the Turkish demonstrator 'Soloturk'.
See more of the Turkish 100 Years airforce celebration on this website !
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The World Mission Group meets on the second Monday of the month at 2 pm. The group meets in members’ homes and is open to all who are interested.
The focus of the group is missions and missionaries. Brian Rude, a missionary in El Salvador, is one of the missionaries, as is the Watts family currently in Burundi.
Copyright © 2004–2019 Messiah Lutheran Church of Camrose All Rights Reserved.
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We are looking for fitters of air-conditioning systems and machines, as well as for installers of cleanrooms. While some experience is preferred, it is not essential. Knowledge of the German language is desirable. If you think you fit this description send us your CV to: info@opikar.com.
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Take exit #210, go West on Fruitville Road until it dead ends at US 41. Turn Left (South) onto US 41, continue to second traffic light, then turn Right on Marina Plaza into Marina Jack – Sarasota Bay Front. The Key Breeze is docked at slip E-19 on the North side of the restaurant.
Go North on Tamiami Trail (US 41) to the traffic light at Ringling Boulevard. Pass Ringling Boulevard and turn Left (West) at the next traffic light, Marina Plaza. Once in the parking lot, take an immediate Right and park. Take gate E-1 to slip E-19 where The Key Breeze is docked.
Go South on Gulf Drive, Gulf of Mexico Drive through St Armands Circle and over the Ringling Causeway to Tamiami Trail (US 41). Turn Right (South), continue to first traffic light and turn Right (West) on Marina Plaza (opposite Main Street) into Marina Jack – Sarasota Bay Front. The Key Breeze is docked at slip E-19 on the North side of the Marina Jack restaurant.
Go South on Tamiami Trail (US 41) to #2 Marina Plaza (opposite Main Street). Turn Right (West) on Marina Plaza into Marina Jack – Sarasota Bay Front. The Key Breeze is docked at slip E-19 on the North side of the restaurant.
NOTE: Take the Marina Plaza light (not the Ringling Boulevard light) and once in the marina, turn Right into the parking lot and park immediately. We are between the main restaurant and the statue of the sailor kissing the nurse. Go in any E Gate and find us at E-19 near the Flying Fish Charter Fleet.
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GIVE TO LIFE : What Are You Significant For?
I am Jide Jammal and am the Ceo of this great blog and you are welcome on time out with Jaynaija.
I hope we are still Hungry For Success. I also hope we have set and laid down goals and objectives that we look up to achieving in order to climb the ladder of success in our various field of life.
The Question i have for you today is ; What Are You Significant For? Ask yourself that Question right now. What am i significant for? What do people see you best for?
What is that quality? It is the quality of being noticeable or having effect, impact or influence. When people see you, there is an image you create in their head.
Some People are significant in a certain department, company, field, area or country. Everyone needs to do something to add value to those around us.
When people see Wizkid, Starboy!!! they see him as an icon, not just an icon now, Music Icon, they see him as a music idol not an actor or photographer. The Goals and Objectives Wizkid had set for himself is in the field of music and that’s the picture image on your head when they mention his name or you see him. You can’t hear wizkid now and be thinking of Photographer.
Popular Nollywood Actor, Mr Odunlade Adekola, what is he significant for? Is he significant for playing football or hockey, No!!! He is noticeable for acting. When you talk of actors in Nigeria, if you have not mentioned his names, your list is not complete.
However, our lives should not be the only focus on proving our significance, We should strive to make others significant. Yes, everyone wants to be significant, to be significant, you have to help others to be significant too.
For Jaynaija to become a significant blog when it was first started, it started to promote artistes bringing out the best in them, promoting their musics and Videos and making upcoming Artistes significant like celebrities too. Many individuals are significant because they have taken care of a lot of people and have helped a lot of individual to become successful.
What Are You Significant for? By Contributing to someone else’s success, we become someone who is significant to others.
Want to be Signicant today?
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Published November 8, 2018 at 340 × 457 in 57 Beautiful Photograph Of Hinged Laundry Basket.
This kind of graphic (Hinged Laundry Basket Luxury Nest Of 3 Rattan Baskets with Hinged Lids) over is actually classed together with:published by means of Diane Ellis in 2018-11-08 07:10:18. To determine all graphics throughout astonishing Models Of Hinged Laundry Basket photos gallery remember to adhere to this kind of website link.
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Paparazzi | Truitt Insurance & Bonding, Inc.
Part of the fun we have at Truitt is being able to spend time with our clients, friends and neighbors. We try to stay as active as possible in our community, the associations we are involved in, and with our charitable partners. To us, the relationships we have built are what matter most at the end of the day.
We invite you to share in some of the memories we have captured in our slideshow. We try to be everywhere so you never know, you might even see yourself in here.
BBA's ER VI on the William Penn (2008).
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This is a placeholder page for Collin Houk, which means this person is not currently on this site. We do suggest using the tools below to find Collin Houk.
You are visiting the placeholder page for Collin Houk. This page is here because someone used our placeholder utility to look for Collin Houk. We created this page automatically in hopes Collin Houk would find it. If you are not Collin Houk, but are an alumni of Montpelier High School Montpelier, VT, register on this site for free now.
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Adam Sandler just made another movie – and that may not seem particularly relevant.
He also plays a character called Max Kessler, which is again, not really relevant.
But when you’re an accountant from New York and you look just like Adam Sandler, and your name is also Max Kessler, that’s when it’s relevant.
23-year-old real-life Max Kessler posted a photo of him to Imgur and Reddit after seeing the trailer for Sandler’s new Netflix movie Do-Over, according to Entertainment Daily.
The name of Adam Sandler’s character in his new movie, The Do-Over is Max Kessler. My name is Max Kessler.
Oh yeah, and I look just like him.
While there’s a 20-year difference between the two, it’s hard to deny that the resemblance isn’t uncanny.
Kessler’s post has since been viewed nearly 7.5 million times. But the only view that really mattered was the one from Adam Sandler himself.
If you’re thinking this guy is lying about his name just so he could bag a free trip to LA, you’re not alone.
Max ended up meeting Sandler for the first time at the premiere, where Sandler called him the ‘younger better looking version of me’, and even gave him the nickname Maxy.
Guess it really pays off to have a celebrity doppelganger.
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For dependable corrugated packaging in Crewe, look no further than Cheshire Packaging, the corrugated packaging experts. For more than 25 years, we have been designing and manufacturing high performance corrugated packaging which is suitable for goods of all sizes, values, and weights. From straight forward corrugated boxes designed for heavy duty transit, to reusable corrugated plastic packaging, we have the solution for you at an affordable price. We operate to BSEN ISO 9001:2008 standards and all our packaging can be made bespoke to your exact needs and requirements. So, if you’re in need of corrugated packaging in Crewe, choose Cheshire Packaging today!
At Cheshire Packaging, we have a reputation for always delivering excellent quality and value for money. Nowhere is this clearer than through our corrugated packaging in Crewe. With over two decades worth of experience working with some of the UK’s leading brands, we understand our customers’ needs completely which is why we produce corrugated packaging which is designed specially to keep your goods as safe and secure as possible at all times.
Our conventional corrugated packaging solutions can be shaped to your requirements and it is the number one choice for brands and industries nationwide. Durable and Eco-friendly, we can provide customers with standard slotted containers with protective foam inserts, or die cut custom boxes which are manufactured to your exact specifications.
Our corrugated plastic packaging, or Correx as it is also known, is the go to choice for those looking for corrugated packaging in Crewe which can be returned and re-used. Although initially more expensive, Correx is cost effective in terms of its long term use and the fact that it is waterproof and adaptable. Like our conventional corrugated packaging, Correx can be fully recycled and it can also be easily cut and shaped to suit any design requirements.
Whether you’re looking for a short term solution with corrugated packaging in Crewe, or you’re in need of a long term solution to keep your goods safe and secure during transit and storage, Cheshire Packaging can help! We offer competitive prices and you are guaranteed a high quality product and service which puts your needs first. For more information about our products, or to request a quotation, please contact a member of our team today!
Do you need corrugated packaging in Crewe?
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110" Stroker Motor with Tons of Torque!!
Delivers a perfect amount of Horsepower for Riding on the Street!
Don't be fooled by larger displacement motors that deliver way too much HP and results in broken drive belts, cracked frames-swing arms and transmission failure caused by over-torquing!!!
NOTE: Shipping for Alaska, Hawaii, Puerto Rico and Guam have a surcharge. For foreign freight rates contact us before buying.
Polished Engine Case & Cylinders.
110 Cubic Inch Evolution Style Motor (1788cc).
111 Rated HP, with 125 HP @ Rear Wheel.
Triple Plated Dark Chrome Covers.
Cast from C355 Aluminum (Military Grade).
Pistons: Mahle Forged "Racing Pistons & Rings".
Carburetor: 50.95 mm w/manual choke.
Fuel: 93 Octane Minimum Gasoline.
Air Filter: Mesh High Flow Washable.
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ACDelco Professional Cabin Air Filters will help clear the air - literally. High-quality filtration media removes most airborne allergens and particulates before they reach the vehicle's ventilation system.
* whichever comes first. To the original retail purchaser. Parts only; installation not included. See your local ACDelco Distributor or independent service center that offers ACDelco Parts for details.
• Highly durable and reliable, ACDelco Cabin Air Filters fit most vehicles equipped with cabin air filtration systems.
• Advanced filter media technology helps reduce particles that reach the vehicle's interior for more comfort.
• Highly durable and reliable.
• Removes most allergens from the air before entering the vehicle's ventilation system.
The Filtration System prevents contaminants from entering the engine and transmission while allowing enough fluid or airflow to keep them running properly. A cabin air filter prevents airborne particles from entering the vehicle’s interior. Some designs also remove odours, fumes and smoke.
Excessively dirty filter element, poor cabin ventilation/airflow (blower motor damage could occur if a plugged filter goes unchanged for a long period of time).
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In the last show of the season, the Tiger Dragon Mixed Martial Arts Dojo team dominated the field of schools that participated in the 1st Annual Yellow Elder tournament.
The mixed martial artists fought in three categories on Saturday, at the event which was held on the Yellow Elder Park.
After a brilliant display in each practice, the artists were paired off where they went head-to-head on the mat. Picking up a win over Michael Moss, in the Sanda division, was John Brown. Gino Turner got the best of Stephon Bowleg and George Turner stopped Gabriel Newbold. Marco Fernander and Rashard Gilbert were also winners in the division.
Only one match was held in the Technique division, teammates Kenrick Whyte and Marnarrey Lightbourne battled Actlange Liberal and Jamaal Nabbie. When the artists were separated by the referee, White and Lightbourne emerged as winners. The two represented the Neisi Goju Ryu school and Liberal and Nabbie were members of the Tiger Dragon Mixed Martial Arts Dojo.
Artists in the Kata division were separated based on the degree. The white belt fighters were Lavardo Henfield who won over Lightbourne. Tapping out to Lakeisha Curry was Malik Johnson, in the green belt fight. Whyte won in the purple belt fight.
Clement Eneas, lead instructor at the Tiger Dragon Mixed Martial Arts Dojo, said the artists enrolled in his program do more fighting than the other institutions which rely on forms. He added that the mixed martial arts style combines boxing and kicking, which requires a very high level of training.
He said: ”I am pleased with the way the fighters performed today. They showed great skills and techniques during their matches. We had a good representation and I am very impressed. They did a tremendous job striking, throwing and kicking. The clinching was awesome.
According to Eneas, the school will perform in local and international shows. He said next year’s calendar is almost set and encourages persons to join the growing sport.
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This is just a quick post here. Going through my files, I came across an older video that I filmed of me making a frappe. So I figured hey, why not share it with you guys! I apologise in advance for the shoddy camera work and editing, this was one of the very first videos I made!
This is an idea that I came up with one day when I was obviously very bored lol. It’s a beauty of an idea though! I even had my most skeptical friends of mine taste test this to verify that it tastes good!
This frappe has zero sugar, zero calories, zero dairy, and it only takes minutes to make!
Not exactly rocket science, hey! We’re making a “frappe” made from calorie-free cream soda and instant coffee!
Of course you can pimp yours with added Stevia, protein powder, almond milk, cinnamon, cocoa powder etc etc. Just keep in mind that this will alter the nutritional content if you start adding calories. Keep in mind that they way I have made it, it is literally no calories at all!
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We are justly very proud of Lincroft Academy – it is a school with an excellent reputation, which is well-deserved. We provide outstanding teaching and pastoral care for the students and we achieve excellent standards. Our sporting achievements, musical and dramatic traditions are also really second to none! In addition, Lincroft is a ‘Teaching School’ with well over 100 trainee teachers based at our ‘Pilgrim Centre’, which provides development opportunities for teachers across the region from qualifying through to senior leadership training. Lincroft is recognised as a National Support School, working alongside schools in several local authorities, sharing best practice and improving teaching as a consequence.
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Umar Gul and Shahid Afridi get themselves clicked in their welcome ride.
The iconic Sharjah stadium came alive as over fifteen thousand fans witnessed the opening ceremony of the first ever-international T10 tournament on Thursday evening.
His Excellency Sheikh Nahyan Bin Mubarak Al Nahyan, Minister of Tolerance cut the ribbon, unveiled the trophy and set the tournament underway after hailing the power and skill needed to play this shortest version of the game.
Sheikh Nahyan congratulated Shaji Ul Mulk, the man behind the initiative in his capacity as Chairman of the T10 League, as well all those owners and directors who came out and unstintingly supported this version of cricket. Also present was Dr Nowhera Shaik, Founder & CEO Heera Group, the title sponsor and Salman Iqbal, President, T10 Cricket League.
In a delightful and relaxed manner after the formalities, the six teams did a round of honor of the field each accompanied by dancers from the specific region the teams represent and appropriate music in the background. A riveting display by performance artists and choreographed dances on stage plus a light and sound spectacle truly heralded a great start to the four-day tournament.
Sarfraz Ahmed and the dignitaries at the opening ceremony.
Well known players like Shahid Afridi,Virender Sehwag, Darren Sammy and Shakib Al Hasan received lusty cheers as they walked past. Not to mention the warm welcome received by celebrity attendees including Bollywood actress Bipasha Basu, the wrestler the Great Khali, Suneil Shetty, Arbaaz Khan and Sohail Khan, to name a few.
Kerala Kings defeated the Bengal Tigers by eight wickets in the first T10 international ever played. In the second match, the Pakhtoons defeated the Maratha Arabians by 25 runs.
Kerala Kings beat Bengal Tigers in the opening match.
Friday will see four matches being played starting at 4pm.
Team Fujisoft Falcons were crowned B Division champions of the Y AXIS InSportz Indoor Cricket League after beating Team SFS by 22 runs.
Batting first, SFS scored two runs in their allotted 16 overs with Abdul Raheem Masood top-scoring with 15 runs.
With a low score, Team Fujisoft Falcons cruised to victory with Barjinder Singh (4), Sandeep Nazareth (7) and Muhammed Zaidi (9) impressing with the bat.
Hariharan Gurumurthi of Fujisoft Falcons was named player of the tournament, after scoring 57 runs as well as taking nine wicket for -4 runs.
In the C Division final, Khaleej Times defeated Infinity by 25 runs.
West Indies star Sammy is one of the big names on show.
A new chapter in cricket will be marked on Thursday evening when the T10 League gets underway in Sharjah and before a ball is even bowled, elite cricketers are eager to play their part in making it a big success.
England limited-overs captain, Eoin Morgan, World T20-winning skipper Darren Sammy, ex-Pakistan captain Shahid Afridi and pacer Mohammad Amir are just some of the biggest names to have signed up for the four-day competition at Sharjah Cricket Stadium.
With the 10-over matches lasting just over 90 minutes, the players will be stepping into the unknown of what to expect but Bengal Tigers’ all-rounder Sammy says he has a responsibility to “entertain” the crowd in the stands.
“This format could well create a window and we all have to embrace it,” said the West Indian.
Despite the popularity of the sport worldwide especially the popularity of T20, cricket is yet to be included in the Olympic Games.
But Sammy is convinced the format ticks all the boxes that IOC officials would be looking for.
“If you see Twenty20 matches it brings so much excitement, so then you don’t really know what 10 overs will do,” said Sammy, whose Bengal Tigers’ side open the tournament against Morgan’s Kerala Kings tonight.
6 teams. 10 overs. 90 minutes.
The teams are arriving in style, filled with the greatest cricketers, all set to change the dimension of the game.
For Amir, he’s part of the Maratha Arabians squad that will be coached by Pakistan legend Wasim Akram. His team open their campaign against Pakthoons in the second game tonight and the 25-year-old believes that with the latest of the four matches starting at 22:00, the conditions could well suit him.
“To be honest, it is the new ball,” he said of what would be his biggest challenge.
When asked on the opportunity of working with one of his idols – Wasim, he replied: “I am very excited and I want to learn as much as possible from him in the four days,” he said.
This year’s competition is made up of six teams and organisers have ambitious plans to hold the event in other countries from next year as well as expanding the number of franchises.
And Morgan, captain of Kerala Kings, whose side includes Kieron Pollard and Liam Plunkett, believes even if it’s increased, it wouldn’t impact the tournament.
“It’s the start of something new and excites everybody particularly the concept of a tournament that will start and finish in four days which is unheard of in cricket,” said the 31-year-old.
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Create, run and analyze application performance tests. Help test teams validate scalability, availability and reliability.
This video demonstrates hoLearn how w to use RTP to scale up the load by using IBM cloud resources.
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(Host) The House at this hour is debating legislation that would change the way that many Vermonters receive health care coverage beginning in 2014.
The heart of the bill is a consumer marketplace exchange where individuals and all small businesses would be required to purchase their health insurance.
(Kinzel) House Health Care Chairman Michael Fisher says the legislation will make coverage more affordable for middle-income Vermonters because they’ll be eligible for sizeable federal subsidies.
Fisher says the goal is to encourage small businesses to drop their employee coverage so that their workers can take advantage of these subsidies. He says this approach is good for employers and their employees.
(Fisher) "This is a middle class tax relief bill. It will greatly expand regular Vermonters’ ability to afford access to care. This bill gives us a new freedom for small businesses to focus on what they do best."
(Kinzel) The key issue in the daylong debate was whether or not participation in the exchange should be mandatory or voluntary. Many Republicans, like Milton Rep. Ron Hubert supported the voluntary approach.
(Hubert) "Trust me, if I find that at the end of the first year that I could save $800 by being in the exchange, I’d probably be one of the first ones there. But at the outset, one of the things that we don’t want to be is, we don’t want to be the guinea pigs."
(Kinzel) And Vergennes Rep. Gregory Clark said it was wrong to force people into the exchange.
(Clark) "Vermonters are always willing to be led to the water trough. But, man, they get irritated when they’re heads get forced into the trough."
(Kinzel) But Fisher argued that it’s essential to have a mandatory approach to have as many Vermonters as possible to take full advantage of the federal subsidies.
(Fisher) "So I appreciate the concern about not wanting to mandate and let things roll out the way they want in their own timeline. But we’re talking about significant help for Vermonters here that I don’t want to let go by."
(Kinzel) And Barre City Rep. Paul Poirier said the new system would have the best chance for success if participation in the exchange is mandatory.
(Poirier) "The worst thing we can do for health care reform, Mr. Speaker, is to create a system that we’re setting up to fail. And that’s why I believe we need to all be in."
(Kinzel) The voluntary approach was rejected by a vote of 80-57.
House Speaker Shap Smith provides an outlook on the budget, the tax bill and the governor’s health care bill. Also, Congressman Peter Welch discusses the causes of and solutions for rising gas prices.
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All animals possess some type of tissue repair mechanism. In some species, the capacity to repair tissues is limited to the healing of wounds. Other species, such as echinoderms, posses a striking repair capability that can include the replacement of entire organs. It has been reported that some mechanisms, namely extracellular matrix remodeling, appear to occur in most repair processes. However, it remains unclear to what extent the process of organ regeneration, particularly in animals where loss and regeneration of complex structures is a programmed natural event, is similar to wound healing. We have now used the sea cucumber Holothuria glaberrima to address this question.
Animals were lesioned by making a 3–5 mm transverse incision between one of the longitudinal muscle pairs along the bodywall. Lesioned tissues included muscle, nerve, water canal and dermis. Animals were allowed to heal for up to four weeks (2, 6, 12, 20, and 28 days post-injury) before sacrificed. Tissues were sectioned in a cryostat and changes in cellular and tissue elements during repair were evaluated using classical dyes, immmuohistochemistry and phalloidin labeling. In addition, the temporal and spatial distribution of cell proliferation in the animals was assayed using BrdU incorporation. We found that cellular events associated with wound healing in H. glaberrima correspond to those previously shown to occur during intestinal regeneration. These include: (1) an increase in the number of spherule-containing cells, (2) remodeling of the extracellular matrix, (3) formation of spindle-like structures that signal dedifferentiation of muscle cells in the area flanking the lesion site and (4) intense cellular division occurring mainly in the coelomic epithelium after the first week of regeneration.
Our data indicate that H. glaberrima employs analogous cellular mechanisms during wound healing and organ regeneration. Thus, it is possible that regenerative limitations in some organisms are due either to the absence of particular mechanisms associated with repair or the inability of activating the repair process in some tissues or stages.
For years, researchers have been perplexed by the differences in regeneration capabilities between animal species [1–6]. On the one hand, some species such as Planaria, Hydra or starfish can readily regenerate lost organs or body parts in a remarkable way. In contrast, other species, such as most vertebrates, Drosophila or C. elegans have limited regenerative capacities. Nonetheless, all species have some capacity to heal wounds produced by external factors encountered during their existence. What, if any, is the relationship between these two processes? There are some indications that these processes might differ at the cellular and molecular levels. For example, in sea urchins it has been suggested that healing of broken spines occurs by a morphallactic mechanism involving recruitment of differentiated cells, while regeneration of removed spines and pedicellaria occurs by an epimorphic process involving undifferentiated precursors . And in zebra fish, studies on fin regeneration have found that a fish mutant (dob- devoid of blastema) fails to regenerate the fin but has normal wound healing responses . More recently it has been shown that both wound healing and regeneration in the axolotl are dependent on epithelial/mesenchymal interactions, the formation of the wound epidermis, the restructuring of the extracellular matrix and other cellular/molecular events . These similarities led these authors to suggest that the regeneration capacities of these amphibians is basically a process of superhealing.
A related question that surfaces is whether regenerative processes in animals where regeneration is a common occurrence that follows autotomy or programmed organ loss, differ from those associated with wound healing? This has been suggested to occur in some animals where autotomy usually occurs in localized breakage zones giving rise to the possibility that the regeneration capacities of cells within these zones differ from those of cells in other parts of the animal. In fact, it has been proposed that animals that autotomize organs or appendages, such as echinoderms and arthropods, show a higher potency for regeneration [10, 11].
In answering these questions, it is crucial to determine what mechanisms are shared or differ between the processes of organ regeneration and that of wound healing. We have now used the holothurian or sea cucumber, Holothuria glaberrima, to study the relationship between the two processes. Holothurians are echinoderms, a group that comprise animals renowned for their regeneration capabilities [12, 13]. When exposed to noxious stimuli, H. glaberrima undergoes a programmed evisceration process where most of the digestive tract and associated organs are expelled from the body cavity [14, 15]. Following evisceration, it then regenerates new viscera, being the digestive system the first to be formed. Our group has used this model system extensively, showing that, following evisceration, a new intestine forms from a thickening in the remaining mesentery [14, 15]. The initial intestinal primordium consists of a solid tube that connects the esophagus with the cloaca. Eventually, a lumen is formed and the tube is organized into a functional intestine. The process of intestinal regeneration in H. glaberrima includes, cell division, cell migration, extracellular matrix remodeling and muscle de-differentiation [14, 16–19].
We now extend the use of this model system to study wound healing and to compare the events that take place during wound healing with those previously shown to occur during organ regeneration. To this end, a technique was developed to be able to cause an incision in the bodywall. In particular, the incision was made from the coelomic cavity side of the bodywall; a region that would normally not be subjected to wounds generated from the external environment and therefore cannot be considered a normal programmed event. The incision damaged nerve, muscle, dermal tissues and coelomic epithelia among others. Healing of the wound was then studied during the following 4 weeks. Changes in cellular and tissue elements during healing were evaluated using classical dyes, immmuohistochemistry and phalloidin labeling. Our results show that wound healing in these organisms makes use of the same mechanisms previously shown to occur during organ regeneration, to restore epithelial, dermal, and muscular tissues.
Upon dissecting the animals, the wound was observed under the dissection microscope prior to removing the bodywall section for further processing. The wound by 2 dpi was easily recognized as an oval-shaped fissure, perpendicular to the long axis of the pair of longitudinal muscles, whose borders presented clean cut edges. Inside this gap some tattoo ink could be seen scattered in the tissues; as well, the coelomic fluid contained round bodies 2–4 mm in diameter full of tattoo ink. Some scar tissue was already visible at the injury site by 6 dpi, especially in the dermis of the wall; furthermore, the muscle terminals had a rather smooth appearance and were slanted toward their respective wound edges. At 12 dpi, a connection of provisional matrix that linked the two separated longitudinal muscle terminals was visible; this connection was particularly evident in the medial region of the longitudinal axis of the muscles. The amount of this provisional matrix at the injury site continued increasing and expanding laterally throughout the subsequent healing stages, serving eventually to seal the wound. By 20 dpi the cavity had almost been filled and now only two small oval-shaped apertures parallel to the longitudinal muscles were visible, one at each side of the medial plane of the longitudinal muscle pair. However, the composition and appearance of this matrix was not that of the surrounding muscular tissue, being more translucent and not as dense. The wound was completely sealed by 28 dpi; nonetheless, it could be identified after careful inspection of the tissue, being somewhat recessed in relation to the rest of the muscle. Aside from this, the muscles seemed completely healed and even had the characteristic furrow between them, below which runs the radial nerve and the water canal.
In order to understand the changes that occur during wound healing, it is necessary to have a clear picture of the normal, non-injured bodywall. Fig. 1 provides two different, but complementary portrayals of the bodywall and its different tissues. Staining with the metachromatic stain Toluidine Blue the bodywall dermis, circular and longitudinal muscles and coelomic epithelium can be clearly identified. Alternatively, the use of other markers with fluorescent probes serves to specifically highlight particular tissues. In this case phalloidin labeling shows the muscle tissues while HgCol labeling shows the dense layer of collagen in the bodywall adjacent to the circular muscle.
Bodywall tissue organization. Longitudinal sections of H. glaberrima bodywall depicting its major components, (A) stained with Toluidine blue and (B) double labeled with rhodamine-labeled phalloidin (red) and monoclonal antibody against holothurian collagen (HgCol, green). The main muscle systems and their relationship to the dense and loose connective tissue of the bodywall can be seen. BL-basal lamina of the coelomic epithelia, CB-collagen band, CE-coelomic epithelia, CM-circular muscle, D-dermis, including the loose (lCT) and dense (dCT) connective tissue, LM-longitudinal muscle, M-morulas. Arrowheads identify the ampulla within the bodywall. Bar = 300 μm.
Using Toluidine Blue, we were able to analyze the changes that occurred in the bodywall tissues during the wound healing process (Fig. 2). At 2 dpi the wound site presented a V-shaped structure with a mean distance across the dense connective tissue most proximally to the coelom of 386 μm; the inside edges of this wound had been layered with scarring tissue. The longitudinal muscles and the inner connective tissue of the dermis were exposed and tissue debris and tattoo ink were present within the surrounding area. The vicinity of the wound had been infiltrated by a considerable number of basophilic spherule-containing cells. Interestingly, the staining pattern near the edges had changed, staining darker shades of fuchsia than in non-injured animals. At 6 dpi, the staining near and at the wound edges reached its uppermost intensity coinciding with a substantial decline in the amount of debris at the injury site and its periphery. This stage was also characterized by having an accumulation of provisional matrix in the wound that served as scaffolding, bridging the separation created in the dermis as a result of the injury. This scaffold stained light fuchsia and was infiltrated by basophilic cells; also noticeable, was the presence of small nuclear bodies. In addition, threads of connective tissue appeared to anchor the muscle terminals to the scar. Fusion of the dermal gap at the injury site was completed by 12 dpi, when the dermal substratum beneath the longitudinal muscles was complete. The location where the circular muscle band had been ruptured was occupied by a dense basophilic connective tissue with large number of tightly packed cells. The segment of connective tissue that was in direct contact with the coelomic contents was nearly completely covered by coelomic epithelium that was contiguous with that of adjacent terminals from the circular muscle bands. Nevertheless, dermal tissue architecture was not similar to that of a normal bodywall. It is noteworthy to mention that from 6–12 dpi the laminae of dermal connective tissue in the areas peripheral to the wound appeared separated from one another, suggesting a diminished cohesiveness. Tissue organization was noticeably improved by 20 dpi, when a solid bridge of connective tissue between the muscle stumps had formed and some muscle fibers were present within it; however, there were areas that still consisted mostly of connective tissue. Additionally, dermal tissue architecture improved dramatically by this stage, appearing much more homogeneous in texture and in cellular composition, resembling more closely that of a normal bodywall. Restoration of all tissue components to a practically normal state was attained at 28 dpi; even so, it is important to mention that even at this stage some tattoo ink can still be observed within the bodywall dermis.
Stages in wound healing following transection of H. glaberrima bodywall. Longitudinal tissue sections of injured body wall at (A) 2, (B) 6, (C) 12, (D) 20 and (E) 28 days post injury (dpi) were stained with Toluidene Blue. (A) At 2 dpi the area is filled with debris and a clot has been formed. (B) By 6 dpi, the wound area is filled with a transitory matrix that appears to contain some of the clot material as well as new extracellular material. The muscle has healed and the stumps appear to be regenerating. (C) By 12 dpi the bodywall connective tissue has recovered some of its original organization, although its composition appears different from the non-injured tissue. The longitudinal muscle stumps have grown but have not rejoined. (D) By 20 dpi the connective tissue still appears slightly disorganized but the muscle stumps have connected forming a continuous longitudinal muscle. (E) At 28 dpi, both the muscle and the connective tissue have recovered much of the structure and organization found within non-injured tissue. CM-circular muscle, D-dermis, LM-longitudinal muscle, LMS-longitudinal muscle stump, RN-radial nerve. X's denote the injury site; Asterisks show the presence of tattoo ink used to label the injury site; arrowheads signal the ampulla structures within the bodywall. Bar = 300 μm.
Although classical histology showed that after a partial musclectomy of the longitudinal muscles, H. glaberrima was capable of regenerating muscle fibers across the injury site, the use of Phalloidin allowed for a much more detailed analysis of how the muscle regenerative process occurred (Fig. 3). At 2 dpi the injured longitudinal muscle showed rounded stumps. Discrete muscle fibers could be seen to have extended from some muscle stumps by 6 dpi. However, at this stage they were few in numbers and were only present within 200 um from the stump. Soon after, at 12 dpi, the number and length of fibers had increased and now reached an average of 700 μm into the intervening substratum between opposing muscle stumps. Regenerating muscle fibers seemed to originate from proliferating or migrating myocytes in the muscular tissue, as these fibers were always continuous with the stumps and were never seen isolated as islets of tissue labeled with Phalloidin. A sharp increase in the number of muscle fibers across the injury site was observed by 20 dpi. These were now bundled together and formed a meshwork of muscle bundles between opposing stumps that spanned the wound site; nonetheless, the orientation of these bundles was disarrayed. By 28 dpi, the regenerated segment of muscle possessed tightly packed bundles of fibers that had the same orientation; still, there were few areas within it that were still devoid of muscular tissue, suggesting that some additional time would be necessary for the longitudinal muscle to achieve the compact structure present in normal, non-injured animals.
Wound healing of longitudinal muscle following transection. Body wall sections from animals at (A) 2, (B) 12, (C) 20 and (D) 28 days post-injury (dpi) were labeled with rhodamine-labeled phalloidin to determine the temporal changes in the longitudinal muscle during wound healing. (A) In the 2 dpi animal, only the muscle stumps created by the wound were labeled. (B) By 12 dpi muscle fibers projecting from the wounded muscle terminals can be found across the injury site. (C) Muscle bundles from opposing stumps can be seen to make contact and cover the injury site by 20 dpi but still show a high degree of disorganization. (D) Muscle organization improves by 28 dpi and the density of the muscle bundles increases; however, organization of muscle bundles is still not fully normal, lacking the compact dense structure found in non-injured muscles (see Fig. 1). CM-circular muscle, LM-longitudinal muscle, LMS-longitudinal muscle stumps. X's mark the injury site; The presence of circular muscle depends on the plane of section since the bands of circular muscle are discontinuous. Asterisks show the area where the circular muscle can be found in nearby sections. Bar = 200 μm.
To determine to what extent the process of cell division played a key role in the process of wound healing, dividing cells were labeled with BrdU and measured at different stages (2, 6, 12, 20 and 28 dpi). Dividing cells were easily recognized by double labeling nuclei with Hoescht dye and immunolocalizing the BrdU in cells of animals injected with BrdU the day before. An apparent increase in cell division was observed in the coelomic epithelia and in the longitudinal muscles close to the injury site during the early stages of regeneration when compared to distal tissues or to animals at later stages or controls (Fig. 4). In addition, the number of cells within the coelomic epithelia close to the injury site was observed to increase, probably due to the increase in cell division causing an increase in the width of the epithelia. For purposes of comparison, cell proliferation was quantified at the injury site (mainly connective tissue) and in areas that were both proximal (500 μm) and distal (5 mm) to the injury site (Fig. 4).
Patterns of cell proliferation in response to wound healing. Longitudinal sections were labeled with an antibody against BrdU (green) and Hoescht dye (red) to determine cell proliferation in the longitudinal muscle (LM) and coelomic epithelia (CE). (A) Actively dividing cells were mainly observed in the coelomic epithelia proximal to the injury at 6 dpi. Note that not only the number of dividing cells appears higher but the coelomic epithelium has increased in width. Some cell division is also observed in the muscle layer (arrows) (B) An area distal to the injury site shows much less cell proliferation and a thinner coelomic epithelium. (C) Control (sham-operated) animal at 6 dpi only shows modest cell division and a very thin coelomic epithelium. (D) Minimal cell division is observed at 20 dpi suggesting the stage-dependent role that cell division plays in wound healing. (E) Quantification of cell division at the injury site shows a peak in cell proliferation at 6 dpi. (F) The coelomic epithelia of experimental animals show the largest percentage of diving cells also peaking at 6 dpi. Values of control animals increase slightly but remain significantly lower than experimental animals. (G) Cell division in the longitudinal muscles follows a similar pattern with a sudden peak in cell division at 6 dpi, however the percentage of proliferating cells is much lower than for the coelomic epithelium. CE-coelomic epithelia, LM-longitudinal muscle. PE-Proximal epithelium, PE-C Proximal epithelium-Control, PM Proximal muscle, PM-C Proximal muscle-Control. Bar = 25 μm. Each point represents the mean ± S.E. of at least three animals. *p < .05, **p < .01.
At the injury site, none or little cell division was observed in 2 dpi animals. Cell division began at 6 dpi when about 12% of the cells were observed undergoing division (Fig. 4E). Soon after, by 12 dpi, division levels declined to about 6% and remained constant throughout the subsequent stages.
In the coelomic epithelia, cell division was scarce at 2 dpi; whether one looked at the coelomic epithelium proximal or distal to the injury site only an average of 2 % of cells were observed to be dividing (Fig. 4F). However, at 6 dpi an abrupt increase in cell division occurred both proximally and distally to the injury site. Although both proximal and distal coelomic epithelia showed an increase in cell division, the magnitude in the proximal epithelium was much higher. This increase was even more dramatic if one takes into account that the width of the coelomic epithelium increases during wound healing. In the sham-operated animals there was an increase in cell division in the coelomic epithelia in comparison to normal non-injured animals, but this was still significantly lower than in experimental animals. Furthermore, these control animals did not present the enlarged coelomic epithelium observed in injured animals. A substantial reduction in the extent of cell division took place in both proximal and distal epithelia at 12 dpi, where they exhibited a similar level of cell division. Still, cellular division in the proximal epithelia of injured animals was significantly higher in comparison to control animals. By 20 dpi and forward cell division in the proximal and distal epithelia returned to levels comparable to those of 2 dpi and control animals.
Little or no cell division occurred within the longitudinal muscles at 2 dpi (Fig. 4G). This was followed by a sudden peak in cell division proximal to the injury site at 6 dpi. Control animals presented a small number of scattered BrdU-positive cells within the proximal longitudinal muscle. These numbers were higher than those seen in animals that had not been sham-operated but still remained significantly different when compared those in experimental animals. At 12 dpi, the difference in cell division in the proximal muscle had diminished but remained significantly higher than in control animals. From this stage forth, cell division continued decreasing steadily until 28 dpi, when no cell division was observable in the proximal muscle. Cell division distal to the injury site remained similar from 2 dpi until 20 dpi; beyond this stage practically no cell division was detected distally.
Our group has shown that regeneration of the intestinal system is accompanied by a dramatic process of extracellular matrix remodeling. One of the key signals that ECM remodeling is occurring is the disappearance of matrix components, particularly collagen fibers. To determine if ECM remodeling was taking place during bodywall healing we used the monoclonal antibody HgCol, specific for holothurian collagen . In the dermis of a normal bodywall HgCol recognized a lattice of collagen fibers in the loose connective tissue, immediately below the circular muscle band (Fig. 5). In the dense connective tissue of the bodywall, collagen bundles extended through the dermis, parallel to the longitudinal muscles with collagen bundles appearing to be of a much lesser thickness. It is important to note that the collagen bundles recognized by HgCol did not show an even distribution in the dermis; they were closely packed in the area proximal to the coelom than on the area closer to the epidermis. Aside from this, HgCol also recognized the collagenous component of the thin basal lamina of the coelomic epithelia.
Changes in collagen immunoreactivity during wound healing. Longitudinal bodywall sections of (A) non-injured animals and animals at (B) 6, (C) 12, and (D) 20 days post-injury (dpi) labeled with an antibody against holothurian collagen. The normal distribution of collagen found in non-injured animals (A) is disrupted during wound healing. (B) Initially (6 dpi), collagen is lost close to the wound site; dotted line delimits the area depleted of collagen labeling. (C) However, in subsequent stages (12 dpi) the area where collagen disappears extends over a much wider area. (D) Latter stages (20 dpi) show collagen reappearing as the wound heals. All sections were photographed using the same exposure time (30 sec) to depict the actual differences in labeling intensity. CB-collagen band, CM-circular muscle, lCT-loose connective tissue, dCT-dense connective tissue. Arrowheads signal the ampulla within the bodywall; asterisks mark areas where the tattoo ink denotes the injury site. Bar = 200 μm.
During bodywall regeneration striking changes in the collagenous content recognized by HgCol were observed in the connective tissue of the dermis. Alterations in collagen distribution were observed as soon as 2 dpi, where most of the collagen bundles near the injury site had disappeared and the remaining few appeared largely disorganized. At this stage, remodeling of the ECM was limited to about a 1 mm radius of connective tissue around the injury site. Collagen disappearance was even more evident at 6 dpi; less collagen labeling was found and the connective tissue area from where the collagen had disappeared had extended as far as 2 mm from the injury site. By 12 dpi reappearance of collagen bundles in the bodywall was seen in the dense connective tissue of the dermis, proximal to the coelomic cavity. Still, the arrangement of collagen bundles was disordered. Reconditioning of the ECM to a state resembling non-injured dermis was observed by 20 dpi; at this stage collagen bundles were again parallel and well-stretched. In spite of this, it is important to mention that, even at 28 dpi, collagen labeling was not present in the connective tissue deposited directly at the wound site.
Previous experiments in our laboratory have shown changes in the spherule-containing cell population during intestinal regeneration. In order to determine if similar changes occur during wound healing we followed two spherule-containing cell populations: one labeled with Toluidine blue (named morulas) and one labeled by our monoclonal antibody Sph2 (named spherulocytes). Double labeling experiments showed that when tissue sections were stained with Toluidine Blue and observed under light microscopy, the cytoplasm and spherules of most spherulocytes appeared colorless, while most of the toluidine-stained morula cells were not labeled by our antibody (Fig. 6). Only about 5% of the cells were labeled by both markers.
Changes in spherule-containing cells during wound healing. Tissue sections (6 dpi) stained with (A) Toluidine blue and (B) Monoclonal antibody Sph2, show two sub-populations of spherule-containing cells: (A) morulas and (B) spherulocytes within the body wall connective tissue far from the injury site. The typical round or oval morphology with well defined spherules is observed. (C-D) At the injury site both cell types undergo dramatic change in morphology, and their spherules are no longer clearly discernable. Sph2-labeled cells, in particular, appear to be releasing their cellular content into the surrounding extracellular matrix. Cell counts show that both spherulocytes (E) and morulas (F) increase in number near the injury site during the first two weeks of wound healing. Their numbers return to levels found in non-injured animals (dotted line) during the third week. A concomitant decrease in cell numbers distal to the injury site is also observed during the first 2 weeks. Dotted line denotes the number of cells found within the bodywall of non-injured animals and of controls. dCT-dense connective tissue, lCT-loose connective tissue, PN- peripheral nerve. Asterisks show the tattoo ink; used to label the injury site; X's denote the injury site; arrows indicate morulas; arrowheads indicate spherulocytes. Bar = 50 μm. Each point represents the mean ± S.E. of at least three animals. **p < .01.
We observed changes in both cellular populations during the wound healing process. The spherulocyte population appeared to increase near the injury site. Spherulocytes were also observed to go through a striking alteration in their morphology. Cells that were present distant to the injury site, similar to those found in controls and non-injured animals, were round or oval and possessed well defined spherules within their cytoplasm. When these cells were in close proximity to the injury their spherules were no longer discernable and the labeling appeared less intense and seemed to extend into the extracellular matrix. To quantify the changes in the spherulocyte population, the number of cells were counted near the injury site and compared with cell numbers distant to the site and in control animals (Fig. 6E). By 2 dpi, the spherulocyte population already showed a twofold increase in numbers. The changes in cell number and morphology continued during 6–12 dpi. At latter stages (20–28 dpi) cell numbers returned to levels comparable to those of non-injured animals, however, some cells still showed morphological alterations; their spherules were not clearly discernable. An important observation that needs to be emphasized was that while the number of spherulocytes near the injury site increased during the wound healing period, a 32 % decline in their numbers was detected in areas of the dermis distal to the injury site, suggesting that cells were migrating from non-injured areas to the injury site.
The second spherule-containing cell population, the morulas, was also observed to increase in number in response to injury (Fig. 6F). Clustering of these cells near and at the dermal edge created by the incision began as early as in the 2 dpi stage, when a three-fold increase in their numbers could be observed. This peak in cell number was maintained until 12 dpi, after which cell numbers declined to quantities similar to those in normal animals. These cells also showed a parallel decline in their numbers distally to the injury site at stages where an increase from basal levels was registered proximally. A distinctive characteristic of this cell population was that, although they appeared to migrate to the injury site, only a few showed a change in morphology.
Previous studies from our laboratory have shown that dedifferentiation of cells within the intestinal mesentery occurs during regeneration of the digestive tract in H. glaberrima . One of the hallmarks of this dedifferentiation is the formation and elimination of spindle-like structures (SLS's) made from the contractile apparatus of the dedifferentiating muscle cells. To determine if formation of SLS was also occurring after bodywall lesioning we used the fungal toxin Phalloidin, which binds the polymeric form of actin in the muscle contractile apparatus. Labeling of SLS's using this marker showed the presence of an astonishing amount of SLS's throughout the wound healing process, not only at the injured site, but also in areas distal to the injury. At the injury site, SLS's were present from stage 2 dpi, probably originating from the muscle fibers that had been damaged by the incision (Fig. 7A). As expected, SLS's were shown not to contain nuclei (lack of co-labeling with Hoescht) and were mainly found within the clot or temporary matrix that had formed at the injury site.
Formation of spindle-like structures (SLS) by muscle cells during wound healing. (A) Double labeling of muscle tissue with rhodamine-labeled phalloidin (green) and Hoescht (red) shows the presence of SLS at the injury site. The lack of nuclei within or near the SLS shows the non-cellular nature of these structures. (B) Rhodamine-labeled phalloidin shows the circular muscle band at 6 dpi proximal to the injury site and the released SLS's (arrows) in the bodywall dermis. (C) Double labeling with rhodamine-labeled phalloidin (red) and an antibody against holothurian collagen (green) shows a magnification of the circular muscle and the SLS in the dermal connective tissue of the body wall. Cell extensions or linkers labeled with phalloidin can be observed (arrowhead). (D-G) Longitudinal muscle sections labeled with Rhodamine-labeled phalloidin. (D) At 6 dpi, proximal to the injury site, showing the loose arrangement of the muscle bundles and the presence of SLS's. (E) Magnification of D shows the large number of SLS's present around and within the muscle fibers at this stage. (F) At 28 dpi the muscle bundles are largely organized, and few SLS are observed. (G) Magnification of F showing the reduced number of SLS at the muscle terminals. (H) Quantification of SLS's shows an increase during the first week of regeneration, from 2–6 dpi. At later stages the number of SLSs decreases, although their numbers remain higher than in sham-operated controls or non-injured animals. Dotted line denotes the number of cells found within the bodywall of non-injured animals and of controls. CB-collagen band, CC-coelomic cavity, CM = circular muscle, lCT loose connective tissue, LM-longitudinal muscle, SLS's-spindle-like structure. Arrowhead indicates the SLS phalloidin-positive linker. Bar = (A&C) 10 um, (B) 25 μm, (D& F) 200 μm, (E & G) 50 μm. Each point represents the mean ± S.E. of at least three animals. **p < 0.01.
Formation of SLS's, was observed within the cells of the circular muscle bands during the healing process. These muscles encircle the coelomic cavity and are surrounded on the dermal side by a dense lattice of collagen fibrils and on the coelomic side by the coelomic epithelium. In the area where the circular muscle band had been ruptured by the injury, SLS's were first noticeable in both muscle sides at 2 dpi. At 6 dpi, they began appearing farther away from the lesion point, on the muscle band contiguous with the terminals created by the injury (Fig. 7B). Peak occurrence of SLS's in the circular muscle bands also took place at 6 dpi, followed by a sudden decline in their frequency at 12 dpi. From this point forward they gradually disappeared to the point of no being detected at 28 dpi. It is noticeable that SLS's ejected from muscle cells into the collagen rich lacunae of the bodywall appeared to remain attached to the dedifferentiating muscle cell by the presence of a cellular extension or linker that labels with Phalloidin and was mainly observed during the 6–12 dpi period (Fig. 7C). In contrast, SLS's discarded to the coelomic surface appeared to be unattached to the remaining muscle cells.
A similar tendency in SLS's formation was observed within the cells of the longitudinal muscle. At 2 dpi, formation of SLS's was restricted to the terminals of muscle tissue adjacent to the lesion. However, at 6 dpi SLS's were present farther away from the lesion area and in the distal regions of the muscle band (Fig. 7D–E). An abrupt deterioration in the muscle organization was also observed, specifically a reduction in the cohesiveness of muscles bundles to the point where individual bundles could be seen. SLS formation decreased at later wound healing stages (Fig. 7F–G).
Quantification of SLS formation was performed to determine the temporal aspects of changes in the muscle structure (Fig. 7H). SLS's were counted per field of view at different wound healing stages. The peak in SLS formation was shown to occur at 6 dpi. Not only were there more SLS's counted per area, but these could be detected as far as 6 mm from the lesion point. By 12 dpi muscle fibers organization was greatly improved and the presence of SLS's confined once more to muscle terminals. From 12 dpi and forth SLS's continued declining, where at 28 dpi little or none could be seen, and muscle organization was virtually comparable to that of an unlesioned animal. If SLS's were present at this stage these were mostly restricted to the injured muscle or to where the overlapping muscle bundles from opposing stumps were in contact. At all stages, formation of SLS's in the longitudinal muscle was predominantly restricted to the coelomic surface of the muscle.
Retractor muscles in the papillate podia, or non-locomotory protrusions, of H. glaberrima were also observed to form SLS's in their muscle cells in response to the injury. This phenomenon was more conspicuous in the retractor muscles immediately below the injury. At 2 dpi, these muscles presented an intermediate level of SLS's occurrence. It was at 6 dpi when most SLS's were observed and a large of number accumulated inside the papillate pits. At 12 dpi SLS's had decreased drastically; and from there on little if any SLS's were observed in these tissues.
Here we have described the process of wound healing in the echinoderm H. glaberrima and some of the cellular events that take place during this process. We will first discuss the healing process itself in view of what has been described in the literature for other echinoderm species. However, our main interest in undergoing this study was to compare the cellular events that occur during wound healing to those that occur during organ regeneration. By far what has attracted the attention of scientists to the echinoderms has been their capacity to regenerate following autotomy, where the detachment of the limbs or organs serves a defensive function . In most cases regeneration following autotomy involves not only the restitution of particular tissues but the complete formation of an organ or arm. Nonetheless, certain aspects of regeneration, particularly those that occur early in the process and are involved with the healing of the cut or severed surface, can serve as points of comparison to our results.
Therefore, the main part of this discussion will focus on the four events studied: (1) cell proliferation (2) increase in spherule-containing cells (3) ECM remodeling and (4) SLSs formation (and its association with muscle dedifferentiation) and the comparison to intestinal regeneration.
There are surprisingly few studies describing wound healing in echinoderms and even those that study wound healing show some differences between them. Two studies have focused on cutaneous wound healing: one in Stichopus badionotus and a second one in Thyone briareus . Both groups of investigators show that wounds heal rapidly (2–3 weeks) with little or no cell division during the early healing stages, but with abundant cell migration. However, they report different findings on the type of cells that migrate and might be involved in the healing process. Our results are consistent in also showing rapid wound healing, little cell proliferation during early stages and changes in cell number that suggest cellular migration toward the wound site. However, our results are not wholly comparable since the previous studies were done following cutaneous injuries that did not affect the musculature while our injury was done on the coelomic side of the bodywall and caused damage to muscular, nervous and dermal tissues. In addition our results show other cellular events that went unnoticed to the previous investigators probably due to, differences in species, in wound type or most probably because of technical limitations.
As mentioned above, there has been some controversy as to the role of the spherule-containing cells in wound healing in holothurians. For the sake of this discussion, we would refer to two types of spherule-containing cells: morula cells, that are labeled with classical histological dyes [21–23] and spherulocytes that are labeled by our monoclonal antibodies . An initial study on the morula cells during superficial cutaneous wound healing in the sea cucumber Stichopus badionotus found no significant change in their numbers, thus, suggesting that this cell type does not play an important role . However, more recent works in two other sea cucumber species, Thyone briareus and Eupentacta quinquesemita question this conclusion [22, 23]. They found that numerous morula cells accumulate in the hypodermis of the wound area during the first two days following excision of a portion of the integument . They also report that in incision wounds, the morula cells invade the wound area in large numbers. Similarly, studies of the changes that occur in E. quinquesemita during introvert dermis evisceration and regeneration, suggest that morula cells accumulate in regenerating extracellular matrix and provide some of the ground substance material for tissue repair .
Our results are in accordance with an important role for morula cells in the wound healing process of holothurians. The increase in number at the injury site during the early stages of wound healing surely suggests that they are somehow involved in the process. Moreover, the fact that their numbers in nearby (non-injured) areas diminish also suggest that morula cells are being actively recruited into the injured area. Differences of these studies with others could be due to the latter only doing superficial injuries or to species differences.
When wound healing is compared to intestinal regeneration one observes, that in contrast to their role in wound healing, morula cells do not appear to play an important role in intestinal regeneration. Although they are present within the regenerating intestine, their numbers actually decrease during the initial stages of regeneration .
Spherulocytes appear to be also involved in the process of wound healing. Moreover the changes observed in these cell types during wound healing parallel those observed during intestinal regeneration . In both wound healing and regeneration the number of these cells, localized in the connective tissue, increases. In addition, during both processes they also undergo a dramatic change in their morphology. Complementary to this change in morphology is the alteration seen in the labeling pattern, which is no longer restricted to the interior of the cells but seems to be on the extracellular matrix suggesting that they are releasing their vesicular components into the extracellular matrix. Finally, during wound healing spherulocytes appear to migrate from the adjacent dermis into the wound site. Similarly, during intestinal regeneration, spherulocytes appear to migrate into the regenerating intestine via the mesentery connective tissue .
Finally, our results provide for some interesting comparisons between the morula and spherulocyte populations. It has been proposed that the different spherule-containing cell populations reflected cells at different stages of maturation, where the deeply stained cells were younger, and as they matured, their granules were only weakly stained . Based on this, we had previously proposed that spherulocytes were morula cells at a later stage in their maturation . However, the present data questions this interpretation since they show that both morula and spherulocyte populations increase concomitantly, and both appear to migrate into the wound area. Moreover, less than 5% of the cells are labeled with both the antibody and the histological stain. Thus, the data is more consonant with both cell types being independent cell types rather than being the same cell type at different maturation stages.
The consensus among investigators that have studied holothurians is that little cell proliferation occurs during the early stages of wound healing and that most of the repair in the early stages is accomplished by displacement of cells rather than by proliferation. This has been reported in the sea cucumbers Stichopus badionotus and Thyone briareus where no significant mitotic figures were observed during the early stages of cutaneous wound healing [21, 22]. Our result showing that less than 2% of cells are dividing at 2 dpi certainly fits within what has been found in other studies.
Although the small amount of cellular proliferation that takes place during the early stages of wound healing might seem surprising, this is somewhat similar to what has been found to occur during regenerative events in holothurians. In our previous studies using BrdU labeling during intestinal regeneration in H. glaberrima, a small level of proliferation was documented during the early days of intestinal regeneration, while the increase in cellular proliferation occurs between 7–14 days . Similar results have been documented in other species using other techniques; in Stichopus mollis by counting mitotic figures and in Eupenctata fraudatrix using radioactive thymidine [26–29]. Thus, once again in the sea cucumber, the wound healing events are similar to those found during organ regeneration.
Another resemblance between wound healing and intestinal regeneration, is that in both processes the coelomic epithelium stands out as a center of cell proliferation. This was observed in our previous studies of intestinal regeneration in H. glaberrima where the division of the coelomic epithelial cells was much higher than those within the connective tissue . Similar percentages in cellular division of the coelomic epithelia were found in this study following wound healing. The important role of the coelomic epithelia in cell proliferation during regenerative events seems to be a common theme to many echinoderm species, having been shown to occur in crinoid arm regeneration and in arm and pyloric caeca regeneration in starfish [31, 32]. Moreover, the proliferation of the coelomic epithelia appears to play a significant role in the restitution of echinoderm tissues since it has been proposed these cells give rise to other cellular types and not only coelomic cells [18, 29, 33, 34].
Cell proliferation also plays an important role in the wound healing of other animals. In mammals, where it has been best studied, a proliferative phase takes place usually 3–5 days following injury [35, 36]. Some of the proliferating cells are fibroblast that migrate and proliferate in response to growth factors and eventually play a role in the synthesis and deposition of ECM.
There is little discussion of changes within the ECM in previous reports of holothurian wound healing or for that matter in reports of regeneration following autotomy. There are reports of loosening of the ECM fibrils near the wound site and of a zone of degeneration in the deeper collagen bundles , but little additional descriptions are provided. Collagen deposition appears to occur rather fast, within a few days of cutaneous wounding in S. badionotus . The difference between this report and our findings where, collagen deposition occurs much later might be due to the limited amount of damage in previous studies, where only the epidermis needs to be restored prior to the new ECM being deposited. In contrast, in our studies where other tissues, such as muscle and nerve, need to be healed it might be necessary to maintain a temporary matrix for a longer period prior to the deposition of the permanent one. However, the differences between the previous report and our data might also be explained by technical limitations in identifying particular ECM molecules or changes in ECM, at the time those experiments were performed.
Previous experiments from our laboratory have shown that during regeneration of the intestine in H. glaberrima there is a striking remodeling of the extracellular matrix within the mesentery . Among the features of this ECM remodeling are changes in ECM components, activation of matrix metalloproteases and the increased presence of cells involved in matrix degradation and matrix deposition [16, 19, 24]. One of the hallmarks of the ECM remodeling is the disappearance of ECM collagen, particularly from the mesenterial ECM close to the regenerating intestine. Our results with wound healing show noteworthy similarities to the events that occur during intestinal regeneration. In particular, the disappearance of collagen immunoreactivity in the wounded area and in areas adjacent to the wound, and the temporal scheme in which this occurs. Collagen immunoreactivity diminishes greatly within the two weeks that follow the injury and this decrease occurs not only in the tissue that has been wounded but extends to nearby tissue. During regeneration, collagen also disappears from the mesentery adjacent to the regenerating intestine and a gradient in its disappearance is also observed as one moves from the mesentery edge towards the bodywall.
That ECM changes occur during wound healing of the sea cucumber bodywall is not surprising, since such changes have been associated with the healing of wound in all, if not most, animals where it has been studied. For example, during skin wound healing in mammals, the ECM collagen is degraded and replaced with a temporary matrix [35, 37]. This temporary matrix is eventually degraded once the tissues are regenerated and collagen is once again restituted . Similar events have been documented in other organisms following injury . However, one of the consistent findings that differentiate the holothurians from other species is the timing of the response. Collagen disappearance occurs during a 1–2 week period following either injury or evisceration and the reposition of collagen occurs 1–2 weeks afterwards. In contrast in mammals and other species, collagen is degraded and restituted much faster.
Recent findings from our laboratory have shown that muscle cells in the mesentery of H. glaberrima undergo a process of dedifferentiation during intestinal regeneration . This process can be followed by the appearance of spindle-like structures (SLS's) that are formed from the muscle contractile apparatus. In fact, the formation of SLS's has been shown to be a definite signal of muscle dedifferentiation in echinoderms [27–29, 34]. During intestinal regeneration in H. glaberrima, these SLS's are formed by the muscle cells located in the mesentery and are then eliminated either into the coelomic cavity or phagocytized by amebocytes in the connective tissue.
There are various similarities between the process of muscle dedifferentiation in intestinal regeneration and wound healing. First, cellular dedifferentiation as determined by SLS's formation occurs during the first and second week following the traumatic event. Second, some of the SLS's are eliminated into the coelomic cavity. An additional similarity is that the dedifferentiation process appears to occur in a gradient, showing high levels close to the injury site and lower levels as one moves distant from the injury site. Such a gradient suggests the presence of a soluble diffusing molecule that might be responsible for muscle dedifferentiation. In this respect, it is interesting that a soluble factor from serum that appears to play a similar role in the dedifferentiation of amphibian myocytes has been partially characterized .
Muscle dedifferentiation and formation of SLS's is not restricted to holothurian species. It has been documented in various other echinoderm species undergoing regenerative processes including visceral and longitudinal muscles of sea cucumbers [27, 28, 34, 41, 42] and crinoid arm muscle [34, 42]. Likewise, elimination of the contractile apparatus and formation of de-differentiated cells from muscle cells has been documented in many other invertebrate and vertebrate species during regenerative procedures. Examples of these are the muscle cell dedifferentiation that occurs during annelid regeneration [43, 44] and in amphibian tail and limb regeneration [45–47]. Thus, available data strongly suggest that muscle dedifferentiation is an important component of regeneration processes.
To summarize the comparison between the cellular events that occur during wound healing and those that occur during regeneration, we have prepared graphs showing the relative extent of the event during four weeks following the injury or evisceration process (Fig. 8). The similarities in terms of magnitude and timing of these events are striking. Except for the increase in spherulocytes all other events follow almost identical temporal sequences in regeneration and in wound healing. The difference in the spherulocytes can be ascribed to the fact that these cells appear to be migrating from the bodywall during the regenerative process and thus, take longer to reach the intestinal primordia. In contrast, these cells are quite numerous within the bodywall and therefore are readily available near the wound site. Nonetheless, it is important to emphasize that spherulocytes are still numerous during the second week of wound injury, thus, although the increase in number begins earlier than in regeneration, they still are present in high numbers at the same time their number peak during regeneration, suggesting a similar role in both processes.
Comparison of the cellular events that occur during wound healing and organ regeneration. The four cellular events highlighted in this study were compared to those that occur during intestine regeneration [14, 16, 19, 24]. For this the magnitude of the events was assigned a relative value between 0 and 5 at the various time points where they had been studied. Each event shows a particular expression profile, nonetheless, a stunning similarity is observed between regeneration and wound healing in both the temporal pattern of the event and the peak of occurrence. Additional details provided in the text. (A) Spindle-like structure (SLS) formation, (B) cell proliferation, (C) Extracellular matrix (ECM) remodeling and (D) increase in spherulocyte population.
The graphs also serve to highlight the temporal sequence of the evisceration/wound healing related events. It seems, that the cellular event that occurs earlier in both processes is the dedifferentiation of muscle cells. The highest numbers of SLS's are usually observed within the first two weeks and decay thereafter. Other events peak during the second week of regeneration/wound healing. Of particular interest is the fact that little cell division occurs during the days following injury or evisceration and that most of the cell division occurs at the end of the first week or during the second week, thus suggesting that the initial cells involved in wound healing and regeneration processes are mainly cells already found within the tissues or cells that result from the dedifferentiation event. Experiments are in progress to determine the role that the dedifferentiated cell population plays in the regeneration and wound healing processes.
In an essay entitled "What controls organ regeneration?", Davenport states that in order to understand the mysteries of regeneration it will be necessary to determine what separates the human (or mammal) wound healing process from that of animals that are able to regenerate. Our data provides some light into this issue. Two of the cellular events, cell proliferation and ECM remodeling, are observed in non-regenerating species during wound healing. However, there might still be some differences between these processes and those found in animals capable of organ regeneration. For example, cell division usually is documented to occur much faster in mammalian wound healing than what we have documented for holothurians. But in other regenerating species cell proliferation is known to occur widely. In fact, regeneration processes have been traditionally divided into epimorphic processes where high cell proliferation occurs within a blastema and morphallactic processes where little or no cell division occurs and the new organ is formed from pre-existing cells [3, 13]. Thus, it is unlikely that the pattern of cell division can serve to differentiate animals capable of extensive regeneration from those whose regenerative properties are limited.
In contrast, there appears to be some notable differences among regenerating and non-regenerating animals in terms of ECM remodeling. In H. glaberrima ECM remodeling extends over weeks rather than days and the peak in both collagen disappearance as well as in its deposition appears to be much later than during wound healing in mammals. ECM remodeling has been highlighted as one of the mechanisms that is found to occur widely in animals capable of organ and limb regeneration. It has been shown to occur during newt limb regeneration [39, 49–52] rat liver regeneration , Hydra head regeneration [54, 55] and zebrafish fin regeneration . In mice, ECM remodeling, and in particular the activity of the matrix metalloproteinases, has been shown to correlate with the regeneration ability of two mice species: those where the activity of the enzymes is higher and last longer show better healing of ear wounds . Therefore, the timing and extent of ECM remodeling might be an important factor associated with the enhanced regeneration capacities.
Comparisons between regenerating and non-regenerating animals, in terms of the population of spherulocytes are not practical at this time. First, because, their role in holothurians is not clear. They have been associated to the production of a transitory ECM [23, 24] but have also been implicated in defense mechanisms [58–60]. Second, because it is uncertain if they have analogous cell type in other species. Some investigators have suggested they are similar to mast cells [21, 22, 24] but this possibility remains undetermined. Nonetheless, the association of this cell type with the process of wound healing and regeneration in holothurians is worth further exploration, particularly in view of their capacity to release their vesicular contents which might include not only ECM components but growth factors, cytokines and other molecules associated with the cellular events that have been observed.
Out of the four cellular events that occur during holothurian wound healing and regeneration, the only one that appears to be prominent in regenerating species but not to occur in poor regenerators is the dedifferentiation of muscle cells. As discussed above, this process has been documented in various animal species ranging from annelids to amphibians. Moreover, the process could be the source of stem cells that eventually provide the different cell phenotypes necessary for the formation of the new organ [61, 62]. Such a possibility has been explored by the laboratory of Tanaka [6, 47] showing that, in amphibian tadpoles, cells that originate from muscle cell dedifferentiation gave rise to a variety of cell types. The process of dedifferentiation is not limited to muscle cells. In fact, other cells have been shown to dedifferentiate during the process of regeneration. The best documented is the dedifferentiation of the dorsal iris cells to produce the new lens in salamanders . While recently, it has been shown that dedifferentiation of digestive cells into blastema-like cells occurs in Hydra during head regeneration . Therefore, cell dedifferentiation might be one of the key processes that separate good regenerators from poor regenerators. Thus as has been suggested by Han and colleagues "gaining access to developmentally regulated programs (dedifferentiation) lies at the heart of the regeneration problem in mammals".
The cellular events that occur during wound healing in H. glaberrima, namely the pattern of cell division, increase in the spherulocyte population, ECM remodeling, and muscle dedifferentiation are similar to those that take place during intestinal regeneration. Thus, our results show that, at least in H. glaberrima, but probably in most echinoderms that undergo organ or arm regeneration following autotomy, the same processes that are used for regeneration of complex structures are used for wound healing. Of the four events, muscle dedifferentiation appears to be a common mechanism to animals that posses a high regeneration capacity thus suggesting that this mechanism is of great importance to the regeneration process in metazoans.
Holothuria glaberrimaspecimens were collected in the northeast coast of Puerto Rico and maintained in the laboratory in recirculating seawater aquaria with constant oxygenation.
Animals were eviscerated by injecting 0.35 M KCl (3–5 ml) into the coelomic cavity. One hour following evisceration, animals were anesthetized by submersion in 0.2% 1,1,1-Trichloro-2-methyl-2-propanol hydrate (chlorobutanol) in sea water. Once they were fully relaxed, approximately 10 min, exposure of the longitudinal muscle was achieved by pushing the bodywall from the outside with a blunt rod through the cloaca. This left exposed nearly 2 cm of the dorsal wall that faces the coelomic cavity, hence, providing accurate and easy access to the longitudinal muscle. The injury was performed by making a perpendicular incision with a scalpel between the longitudinal muscle bands, 3–4 cm anterior to the cloaca and about 2 cm from the point of stress. Injured tissues included longitudinal muscle, circular muscle, radial nerve, water canal, bodywall dermis and coelomic epithelia. Control animals were subjected to the same inversion procedure except that no lesion was made. In the experimental animals, the injury extended 1–1.5 mm into the inner dense layer of the dermis and the lesion site was then marked with red tattoo ink to be able to identify it later during dissection. Animals were returned to the aquaria and allowed to heal for different days (2, 6, 12, 20, and 28) post-injury (dpi). Before sacrificed, animals were again anesthetized with chlorobutanol, dissected, pinned and initially fixed with 4% paraformaldehyde poured directly into the dissecting dish for 30 min. The area around the incision was then localized and a 6 mm × 12 mm rectangle was dissected and kept overnight in 4% paraformaldehyde. Tissues were maintained in 30% sucrose until use. All dissections were carried out using a Wild-M5A dissecting microscope (Wild Heerbrugg, Switzerland).
Bodywall fragments were embedded in OCT embedding medium (Tissue Tek OCT; Miles Inc.), frozen at -20°C and longitudinally sectioned (20 μm) in a cryostat (Leica CM 1900). Sections were recovered on poly-lysine-treated slides, left to dry for at least 1 hr under cold air and stored until use. All sections used for data analysis were from bodywall tissues not farther away than 200 μm from the medial plane of the longitudinal muscle pair, where the distance across the injury was greatest. Proximal regions were 0.5 mm from the injury site while distal regions were 5 mm away, approximately. Images were recorded and analyzed using the MetaVue software (version 6.0; Universal Imaging, Inc.).
To assess the progress of wound healing, the distance between muscle stumps labeled with phalloidin were measured from 10× micrographs at different stages (2, 6, 12, 20, 28 dpi). For each specimen, five to ten sections were analyzed under fluorescence microscopy and the shortest distance, for each animal, between the muscle terminals was recorded.
Also, the extent of muscle regeneration was quantified by measuring the length of the regenerated fiber from the muscle stump to the farthest point in the regenerating front. For each animal, five to six measurements were taken and the mean value was calculated for each animal, pooled with other values for that same stage, then a final mean was calculated.
Slides with longitudinal sections of the bodywall were used to determine the temporal progress of healing in the injured tissues. Cryostat tissue sections were treated with Toludine blue as described by Presnell and Schreibman . In brief, the sections were rinsed in PBS for 2 min, and then immersed in dye solution for 2 min. They were then rinsed in PBS, mounted in buffered glycerol phosphate and viewed under the microscope. In some cases, staining was done on tissue sections previously processed for immunohistochemistry (see below).
The immunohistochemical procedures used have been described elsewhere [14–16, 18, 65] Cryostat tissue sections were treated with goat serum (1:50), permeabilized with 0.5% Triton X-100 and incubated overnight with the corresponding primary antibody: Anti-BrdU (1:5, Amersham), Sph2 supernatant or HgCol supernatant in a humid chamber. The following day, sections were rinsed in PBS and treated with the FITC-labeled goat-anti-mouse secondary antibody (1:50, BioSource Int.). For double labeling, phalloidin-rhodamine (1:200, Sigma) was added together with the primary antibody. Sections were rinsed again in PBS and mounted in buffered glycerol. Double or triple labeling with Hoechst nuclear dye (Sigma) was done by immersing slides in 1 μM Hoescht for 15 min after the primary antibody [14, 18]. Sections were examined and photographed using a Nikon E600 microscope equipped with FITC, R/DII and DAPI filters. Images were recorded using the MetaVue software (version 6.0; Universal Imaging, Inc.).
The number of spherule-cells labeled by immunological (Sph2) and histological (Toluidine blue) stains were quantified by counting the number of labeled cells in an area of 280 mm2 (the microscope field of view using the 40× objective). For these experiments we used longitudinal sections of the bodywall labeled with Sph2 and stained with Toluidine Blue simultaneously; previous testing confirmed that the dye Toluidine Blue did not affect Sph2 labeling. Cell numbers were obtained from the inner (dense) layer of dermis proximal and distal to the injury site at various stages during the wound healing period. Cell counts were done in two fields of view chosen at random for each corresponding area in every animal and in at least three animals per stage of regeneration. Student's t test and ANOVA's were used for statistical analyses.
Previous work from our laboratory and that of others has shown that muscle cells can dedifferentiate forming spindle-like structures [19, 27]. To examine if muscle cell de-differentiation was taking place during wound healing and the possible extent of this occurrence, the numbers of SLS's present in longitudinal muscles of similar width were tallied. Measurements were made at all stages, both distally and proximally to the injury site, in two fields of view (20×) for each corresponding area in at least three animals per stage. Student's t test and ANOVA's were used for statistical analyses.
Analysis of the changes in the extracellular matrix during wound healing was possible on account of the HgCol antibody . For this purpose, 10× micrographs of labeled tissue sections of the wounded areas were taken with the microscope under the same illumination conditions and time exposure settings. To quantify collagen disappearance, the total area in the dermis of the bodywall with no immunoreactivity for collagen was determined. Images were recorded and analyzed using the MetaVue software (version 6.0; Universal Imaging, Inc.).
The temporal and spatial distribution of cell proliferation in the healing animals was assayed using BrdU incorporation. Animals were injected intracoelomically at 2, 6, 12, 20 and 28 dpi with 100 μl of a 1 mg/ml BrdU solution (approximately 0.01 mg/g wet weight) and sacrificed 24 hrs after. Tissues were fixed and treated as described above for immunohistochemistry. Antibodies against BrdU (Amersham) were used to detect cells that had incorporated BrdU. Immunocytochemistry was performed as described above including an additional bath of 0.05 N HCl for 1 h prior to addition of the BrdU antibody, to improve the accessibility of the antibody to the BrdU epitope, followed by an additional 15 min PBS wash.
The labeling index was obtained by counting the number of cells labeled with BrdU divided by the total number of Hoescht-labeled nuclei per microscope field of view. For the longitudinal muscles and their epithelia a mean value for two corresponding areas in each animal was calculated. At least 3 different animals were used for each wound healing stage. Measurements were made at the injury site as well as proximal and distal from the injury site.
Funded by NSF (IBN-0110692), NIH-MBRS (S06GM08102), NIH-RCMI (RRO-3641-01) and the University of Puerto Rico. JSMR is a fellow of the NIH-MARC Program.
JSMR carried out most of the experiments and helped in the analyses of data and preparation of the manuscript. JEGA conceived the study, participated in its design, data analyses and helped in manuscript preparation. All authors read and approved the final manuscript.
|
{
"timestamp": "2019-04-20T08:44:59",
"url": "https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-7-115",
"language": "en",
"source": "c4"
}
|
One of the 2017-season's most exciting new motorhome launches was Malibu's. Now well-established since its 2013 launch, the Carthago sub-brand's line-up grows for 2017. Hitherto, only Malibu van conversions have been available in the UK, but this is going to change, with low-profiles set to make their way across the Channel. They’ll be joined by a brand new A-class range, comprising three models, plus two additions to the panel van conversion range. And we're delighted that these are coming to the UK, as it's an impressive line-up – read on!
All motorhomes in the 2017 Malibu range are based on the recently-revealed Fiat Ducato, powered by the Italian brand's Euro 6-compliant engines.
As we said, two new panel van conversions have been added to the Malibu portfolio for this season: the Van 540 and the Van 600 LE.
The Malibu Van 540 is, as its name suggests, 5.4m-long. It is a two-berth with a rear transverse double bed, that’ll be as much at home on city streets as it is on winding country lanes. Its layout may not break new ground, but the fixtures and fittings are of a very high standard indeed.
Joining the 540 is the 6m-long Van 600 LE. This model has front-to-back rear beds that use the extra length of the base vehicle to offer more legroom than a transverse bed.
Rounding out the new items for Malibu's panel van conversions is a ‘Charming’ style collection (available on two models), while the 600 and 620 models can be specified in the ‘Life’ trim, which adds an electrically-operated drop-down bed and increased storage space by moving some of the ’van’s services.
This is where the biggest changes are in Malibu's 2017 line-up, the existing low-profile ’vans now to be offered to be British buyers, while an all-new A-class range has been introduced.
All models in these segments share the same floorplans, so their kitchens, washrooms and lounges are virtually identical. Where they differ is in the provision of the rear sleeping arrangements, and the possibility to have a drop-down bed above the lounges in the A-class motorhomes.
The T or I 410 features a transverse rear bed and a multifunction washroom, while the T or I 460 opts for twin single beds, again with a multifunction washroom. The T or I 440 has a pull-out island bed, accompanied by a washroom with the luxury of a separate shower compartment.
|
{
"timestamp": "2019-04-21T12:26:53",
"url": "https://www.practicalmotorhome.com/news/39653-new-malibu-motorhomes-for-2017-thinking-big",
"language": "en",
"source": "c4"
}
|
Browse our website and shop online for Freightliner, Navistar International, Isuzu, Mack, Kenworth, VOLVO truck parts and accessories featuring all truck models. PERIPARTS ships truck parts and body parts from over 120 manufacturers to customers' doors worldwide. We sell OEM and replacement truck parts including electrical parts, engine parts, cooling & air parts, drivetrain parts, oil pumps, water pumps, air coolers, condensers, & hd radiators & more with low prices and worldwide shipping on all orders.
Searching for and buying truck parts is both overwhelming and time consuming. Save your time and money - buy truck parts online from PERIPARTS! We offer great savings on every order. You can find over 1,000,000 truck parts in our online store. Contact us now, and we will ensure the best quality and prices.
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{
"timestamp": "2019-04-26T16:07:45",
"url": "https://www.peri-parts.com/other-brands/truck-parts",
"language": "en",
"source": "c4"
}
|
We stepped into the wiring market for a reason. To release what we feel is the highest quality and easiest to install conversion harness available. We’ve used several of our competitor’s harnesses and in short, we felt the need to make several improvements based on the flaws we encountered. Just like every other K-Tuned product, they don’t leave our hands unless we feel that it is a top quality part that we would use on our own personal cars.
A K-swap conversion harness is a must-have part for any K-series engine swap. The harness is required to join up the factory K-series engine harness to the factory dash harness of the swapped car. It is designed integrate the K-series ecu and all of the related electrical functions get them operating properly. Functions like the fuel pump, tach, speedo, starter signal, O2 sensors, etc.
The K-Tuned harness is 99% plug and play and takes very little time to install. The harness is constructed with quality mil-spec spec, oem colored wire and finished with a nice clean looking mil-spec nylon sleeving for protection. Our harnesses come complete with installation instructions and a very cool wire cutter / stripper tool. The end result is a very high quality conversion harness at the best possible price. Several applications are available so get yours to make sure your K-swap is wired up right!
|
{
"timestamp": "2019-04-25T03:48:25",
"url": "https://nipponpower.com/ktuned/ktuned-harness-kswap-conversion/g-63062.aspx",
"language": "en",
"source": "c4"
}
|
Elf Elfonsinio is a Christmas-themed arcade game. Elf was called to Claus Clausie's office. He have done a bad thing—carved toothpicks from Clausie's sleights. As a punishment he has to help Clausie in dressing the Christmas Tree.
Player's task is to hang christmas tree decorations on assigned place. You can choose between seven types of ornaments. Every good spot is scored, but if you hang a wrong bubble, you will pay for it by decreasing all of the score earlier received. When you loose all lifes, your game is over. Short game with good sound and music and pleasureable Christmas theme.
|
{
"timestamp": "2019-04-19T10:55:29",
"url": "https://kalafiorgames.com/elf-elfonsinio",
"language": "en",
"source": "c4"
}
|
Award-winning charcuterie company, Good Game, has been awarded £40k of EU funding, matched by a further £40k investment of their own as part of a growth strategy.
To support the company’s ambition to increase production by 300%, the Topsham based manufacturer has completed its custom-built premises at Darts Business Park. Compared to their previous warehouse in Clyst Vale, the new spacious location will allow Good Game to hang meat, develop new products, package products and create additional office space.
Best known for producing naturally dried game and cured meats made from hand-reared pigs on the Powderham Estate and neighbouring farms, Good Game are on a mission to champion the best tasting charcuterie in the world. Just like artisanal Italian charcuterie, Good Game make everything they produce by hand, using only salt and natural air. Whilst this process takes significantly longer than commercial products, owners Steve Williams and Pete Woodham Kay believe the traditional approach is best. They have also recently secured an organic certification meaning they are one of the only organic and nitrate free producers in the world.
The announcement comes as they unveiled seven new products to their portfolio; rabbit salami, chilli chorizo, nduja (spreadable spicy salami), organic pastrami and salt beef, face bacon, mortadella and frankfurters, injecting further excitement into the UK charcuterie sector.
Good Game currently sell their products to pubs, restaurants, retailers, at their Topsham-based barbecue restaurant, The Pig and Pallet, and online at www.good-game.co.uk.
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{
"timestamp": "2019-04-23T18:34:14",
"url": "http://southwestnews.co.uk/local-news/devons-good-game-set-expand-securing-80k-investment-deal",
"language": "en",
"source": "c4"
}
|
>>NEW IN / 25th JULY.
FINAL SALE DON’T MISS OUT!
SUMMER SALE PETITE ITEM !
>>NEW IN / 18th JULY.
SUMMER SALE RE STOCK !
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{
"timestamp": "2019-04-26T08:38:01",
"url": "http://staffblog.m-i-d.co.jp/official/2018/07/",
"language": "en",
"source": "c4"
}
|
Nanotechnology is having the ability and the knowledge to manufacture products at the nanoscale—one billionth of a meter. All materials that are one-billionth of a meter are invisible to the human eye. The naked eye can see to about 20 microns. A micron (10-6) is one-millionth of a meter. Even using an optical microscope that uses light energy, we can only see materials that are about 1 micron in size.
In Chapter 1 you read about a number of nanotechnology products that are sold today. These products included pants that are stain-resistant, sunscreens that protect the skin against sun rays, medical dressings that are used for burn victims and special nanoparticles used to make tennis rackets and hockey sticks. So, how can you "see," manipulate, and make products at the nanometer scale, the size of atoms and molecules?
• how to manipulate matter at a scale of 1 to 100 nanometers.
|
{
"timestamp": "2019-04-21T01:18:11",
"url": "https://www.texaspowerfulsmart.com/nanotechnology-initiative/the-science-of-nanotechnology.html",
"language": "en",
"source": "c4"
}
|
After the wait, Andrew Bayer finally officially released ‘In My Next Life‘ on Above & Beyond‘s label, Anjunabeats. It’s an album which takes the tracks from his experimental ‘In My Last Life‘, and turns them into club-ready songs.
Fans were introduced to some of those mixes through his performance at Group Therapy 300 in Hong Kong. ‘Immortal Lover‘ and ‘Open End Source,’ both featuring Alison May, saw earlier releases. Those releases were accompanied by Andrew’s collaboration with Genix to remix ‘Love You More‘ featuring Ane Brune. The two’s efforts happen to be the only collaboration on the album.
First on the newer album releases, a fresh club take on ‘Tidal Wave.’ An ethereal pad rises to introduce the hushed and grainy vocal layers, carrying a soft tone. Pads and a lead then propel it into an uplifting club track. Going forward, ‘Hold On To You‘ rockets into an abrasive and dark intro from the start, with the vocals pushing through. It hosts a beautiful breakdown highlighting the melody, with the piano and vocal encompassing it. The string section finally flows the track into the drop section.
The fifth song on the album, ‘In My Last Life‘, has a gentle progression adding elements as the track builds. It cultivates into a hopeful and energetic sound bringing all the elements together. Second to last, ‘Your Eyes‘ intros with a deep and vibrant bass, with a synth melody topping it. Breaking down, the vocals are left with the bass only to kick back into the clubby sound. As soon as you think the track will rise, it falls into an ethereal and bright pad. It’s soon interrupted by a sharp and metallic synth leading into a simultaneously heavy and ethereal chorus. Finally, ‘End Of All Things‘ closes out the album on uplifting and harmonious emotions.
The stark contrast between ‘In My Last Life‘ and ‘In My Next Life‘ cannot be overlooked. Bayer took a chance creating something totally out of the ordinary and nailed it- only to reinvent those same tracks into club-ready anthems. Well done from Mr. Bayer.
|
{
"timestamp": "2019-04-24T14:57:20",
"url": "https://houseofshakes.com/andrew-bayer-releases-reinvented-club-ready-album-in-my-next-life/",
"language": "en",
"source": "c4"
}
|
Stark Reagan represents secured and unsecured creditors, creditor committees, trustees, and debtors in bankruptcy litigation, state court proceedings, negotiated out-of-court workouts, and debt restructuring. Our lawyers use their experience to counsel clients in the process of forming reasonably achievable goals and to represent those clients throughout the process of achieving those goals.
At Stark Reagan, we also represent companies in commercial bankruptcy proceedings and debt collection actions. We can often negotiate a loan modification or forbearance in order to allow companies the time they need to regain their financial footing.
Banks frequently prefer the modification of an existing loan rather than a foreclosure. Depending on the financial situation of your company, it may be possible to work out a loan modification that allows you to stay in business and avoid bankruptcy. Loan modifications and workouts may reduce monthly payments while extending the loan term or may alter the applicable interest rate.
|
{
"timestamp": "2019-04-23T16:55:53",
"url": "https://www.starkreagan.com/Litigation/Bankruptcy-Creditors-Rights.shtml",
"language": "en",
"source": "c4"
}
|
Not even eight propellers could get me to ride this crazy machine.
In this footage captured during a test flight back in May, one of Omni Hoverboards' fantastic creations takes a ride around a lake. From the video, it looks like the device is lifting an adult thanks to eight propellers working overtime underneath.
The propellor approach is good at lifting a person into the air, though it's a contrast to the majority of the new hoverboards we've seen coming out, such as the one from Lexus, that use magnetism to float objects. Omni's website isn't exactly stocked with technical details about the board, though apparently they have patents pending.
The shaky start to the test pretty quickly smooths out. It looks like a wild ride.
The company looks like it's aiming to make the boards commercially available by 2017, which just might be far enough in the future for me to get on board.
|
{
"timestamp": "2019-04-20T00:14:01",
"url": "https://www.popularmechanics.com/flight/a17190/omni-hoverboard-test/",
"language": "en",
"source": "c4"
}
|
Gretchen Keyworth announced the founding of the Fuller Craft Museum in Brockton, Mass., in 2004. New England news services report that she plans to retire as director and chief curator on March 26. She says she looks forward to returning to the pottery studio and pursuing consulting opportunities. She will remain involved with the museum as director emeritus. Read more here.
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{
"timestamp": "2019-04-22T00:47:43",
"url": "https://buyersmarketblog.typepad.com/wholesalematters/",
"language": "en",
"source": "c4"
}
|
Several RV parks are found in South Carolina within 20 miles from Interstate 20, which runs east and west from North Augusta to Florence, where it intersects with I-95. It also crosses I-26 and I-77 along the way, near Columbia. RV parks are found in state recreation areas and in privately owned campgrounds, many near lakes, hiking and other recreation.
In Aiken, there are RV Parks near Augusta, the Georgia state line and Lake Hartwell. Aiken RV Park is only one mile from Interstate 20 and offers full hookup sites in wooded and grassy areas with cable television and free wireless Internet, pet and picnic areas, and nearby golfing. RV camping also is available at the 1,000-acre Aiken State Natural Area, which offers 25 sites with electrical and water hookups, fishing and boating in rivers and lakes and hiking trails.
A few RV parks are near historic downtown Columbia and I-20. Just a few miles from the interstate, The Barnyard RV Park offers daily and extended rates, as well as discounted rates for AAA and AARP members for full hookup sites with 24-hour security. The pet-friendly park has a duck pond, meeting room and flea market. Sesquicentennial State Park is northeast of the city near Fort Jackson and features more than 80 RV sites with water and electrical hookups, an on-site dog park and a 30-acre lake.
West of Columbia, Lake Murray is a destination for bass fishing and boating and other water sports. Siesta Cove Marina is about four miles from I-20, offering RV hookups with daily, weekend and extended rates and amenities like a swimming pool, boat ramps and storage, fishing services and a picnic area. About 20 miles from the interstate, Dreher Island State Recreation Area has almost 100 sites, some lakefront, with boat ramps and fishing areas, all on about 350 acres.
Near the Georgia state line, with an entrance about 20 miles away from I-20 and Augusta, the 700-acre Hamilton Branch State Recreation Area in Plum Branch has RV camping near the 70,000-acre Strom Thurmond Lake with two boat ramps, fishing areas, boating, swimming and bike trails. Less than 20 miles from Interstate 20, Lick Fork Lake Recreation Area offers paved parking campsites with grills and picnic tables, swimming, a fishing pier and a boat ramp for nonmotorized boats and hiking trails.
In Bishopville, Lee State Natural Area is right off I-20 and has RV campsites with water and electrical hookups, fishing in the Lynches River and on the Artesian Lake, horseback riding, trail hiking and an education center. Columbia/Camden RV Park is situated between Columbia and Camden directly off the Interstate in Lugoff, offering more than 80 spaces for nightly and extended rentals, a pond and Internet access.
Floyd, Lisa. "South Carolina RV Parks Near I-20." Travel Tips - USA Today, https://traveltips.usatoday.com/south-carolina-rv-parks-near-i20-51442.html. Accessed 19 April 2019.
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Are you feeling stuck in YOUR business? That’s ok, I think everyone feels stuck at some point. I’ve also felt stuck before in my business growth journey and I can tell you that there were one of the following things involved. Feelings are real, they affect your business because they affect YOU! Read up about what a feeling really is all about in this definition.
If I was inspired to do something, and I didn’t know where to get started, it was an easy way to feel stuck. The good thing is that this didn’t keep me stuck long once I learned to be resourceful – to find answers/solutions. You know that GOOGLE is MY best friend and it should be yours too!
This one is pretty easy to resolve considering there is so much information available at your fingertips, right?
Too much information…wha…wha…yes, you heard that right!
And to take it a step further – find ONE mentor in that area to avoid the overwhelm of too much advice in the same area. It’s like asking directions from a bunch of different people. You only need one path/blueprint and begin taking action to get there. Don’t let your own personal feelings get in the way of making sound business decisions.
Fear – yup – it’s a feeling!
Everyone has felt fear at some point, but the only difference is what do you do with it at that moment? You either can shrink to listen to the “False, Evidence, Appearing, Real” or you can face it using tools and techniques. This way the fear is transformed into something helpful or exciting. Imagining the best case scenario (as opposed to imagining the worst case scenario, which is usually what the fear brings up). Whatever you do, don’t catastrophize because this is the worst thing you can do. There’s nothing worse than beginning with the “fear” and ending with “I quit because I’ll never make it! STOP ALREADY WITH THAT!
If you feel any fear or just plain stuck in your business, I’d like to invite you to help you transform your “stuckness” with me. I offer group mentoring as well as individual mentoring to other Virtual Service Providers (VSP’s). Yup, that is my magical super-power!
Let me help…contact me below and let’s set up a chat so you can move forward with your business and get out of being stuck.
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Orbitas is part of a national scheme which supports bereavement services by recycling metals recovered following cremations. The scheme, aims to benefit the environment and provide a lasting legacy to charities providing bereavement care and support services to people and families within the community through the recycling of metals which have been involved in the cremation process.
This year Orbitas staff decided to support Winston’s Wish, a charity that provides specialist child bereavement support across the UK, giving hope to grieving children and their families.
“Following a cremation, remains can contain metals such as items used in the construction of the coffin and, on some occasions, orthopaedic implants such as hip and knee replacement joints. These items can be recycled but this is only carried out with the explicit prior written consent of bereaved families, and in accordance to strict Environment Agency guidelines.
“We hope that those families suffering bereavement will take some comfort from the fact that a much-loved and worthy cause is benefitting in some way”.
"The support of Orbitas, Bereavement Services and all the bereaved families who have made this donation possible means so much to Winston's Wish.
This amazing gift could fund our Freephone National Helpline number for a year. Last year our helpline provided vital immediate support for more than 4,500 callers.
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After 24 hours in Santa Fe we can’t wait to go back- here’s what I learned about things to do in Santa Fe. The ultimate guide to things to do in Santa Fe!
Our family went to the 2017 Balloon Fiesta in Albuquerque New Mexico and we loved it- from spending time on Balloon Fiesta field to taking tons of gorgeous photos of the balloons, we will definitely go back. On our way home from Albuquerque to Denver, we decided to spend 24 hours in Santa Fe. While that’s not nearly enough time to spend, I’m writing this list of what we did and loved so that we can do the same when we go back!
We stayed at the Santa Fe Sage Inn and LOVED it. It is absolutely nothing fancy, but we loved it for the following reasons: It was super clean, quite, and the beds were awesome. The included breakfast was delicious, and it was only about a 15 minute walk to downtown. There was also a shuttle that ran frequently downtown. Cost? $85 plus tax. And it was next to Whole Foods and the AH-MAZING Shake Foundation Restaurant.
We ate SO well in Santa Fe. I really wanted to eat traditional New Mexican food in Santa Fe and we definitely did. However, we ate first at Shake Foundation– a local burger joint right by our hotel. Not only was the food incredible, there were lots of local families eating and playing there as well, which allowed us to dream about what it would be like to live in Santa Fe some day.
We ate dinner at the Coyote Cafe and Cantina right in the heart of downtown Santa Fe. We had been recommended to eat at The Shed or Pascual’s but weren’t able to because they were totally full. The food at Coyote was delicious- they had these pan fried cornbread fingers unlike anything I had ever tasted. It is a cantina though- the music was loud, there wasn’t a kids meal (they did give us quesadillas), and the seating was all outdoors. I liked it- but we were definitely the only family with young children dining there.
We ate our last lunch at El Parasol. It’s a takeout only place wit super traditional New Mexican fare. Cheap, fast and totally local, I honestly had 5 tacos. The food was delicious, the portions hefty, and we ate a picnic on the sidewalk outside.
One of the reasons that I wanted to go to Santa Fe was to buy fun Mexican flatware, plates and decorations to use for my food photography. The best place to do so is apparently the artesian market near the cathedral, but it only happens on Sunday afternoons and I was too late. There is also an artesian market inside the Farmer’s Market building on Sundays from 12-5, but I was also too late for that.
We went to Jackalope, which has TONS of kitschy souvenirs and lawn decorations from both local and Mexican vendors. It was a fun place to tool around, but the prices were a bit high. I much preferred El Camino Real which was just down the road, had higher quality merchandise and lower prices.
We didn’t get to head over to Meowolf this time- and we are really sad that we missed it. So that is a definitely family “must do” for next time! There are so so so many fun things to do in Santa Fe with kids and we can’t wait to go back and explore.
And that’s it! I can’t wait to go back to Santa Fe and check out the Native American pueblos, do some hiking, go to a spa or two, and of course eat more food. What are your favorite places to go and things to do in Santa Fe, New Mexico? Let us know in the comments below!
Looking for more family travel reviews from Pura Vida Moms?
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The percentage of overweight children has more than doubled in the last 30 years. Overweight children are at high risk of becoming overweight adolescents and adults, placing them at risk of developing chronic diseases such as heart disease and diabetes later in life.
Children become overweight for a variety of reasons. The most common causes are genetic factors, lack of physical activity, unhealthy eating patterns or a combination of these factors. Only in rare cases is being overweight caused by a medical condition such as an endocrine disorder.
Although weight problems run in families, not all children with a family history of obesity will be overweight. Children whose parents, brothers or sisters are overweight may be at an increased risk of becoming overweight themselves, but this can be attributed to shared family behaviors such as eating and activity habits.
A child's total diet and activity level play an important role in determining a child's weight. Today, many children spend a lot of time being inactive.
The best person to determine whether or not a child is overweight is the child’s doctor. If you think that your child is overweight, it is important to arrange an appointment with the child's doctor. In determining whether or not a child is overweight, the doctor will measure the child's weight and height to determine if his or her weight is within a healthy range. The doctor will also consider the child's age and growth patterns. Assessing obesity in children can be difficult, because children can grow in unpredictable spurts.
If your child is overweight, it is very important you let him or her know you are supportive. Children's feelings about themselves often are based on their parents' feelings about them. It is also important to talk to your children about their weight, allowing them to share their concerns with you.
Plan family activities that provide everyone with exercise, like walking, biking or swimming.
Whatever approach parents choose to take, the purpose is not to make physical activity and healthy eating a chore, but to make the most of the opportunities you and your family have to be active.
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This video takes a look at tiny black stoneflies that were hatching while we were out steelheading on March 29, 2009 on the Maitland River in Southern Ontario. These small stoneflies are one of the first insects, aside from midges, to begin hatching in the spring in Ontario. If you plan to be out for steelhead in early spring, consider tying up some tiny black stonefly nymph patterns.
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In a world where technology is advancing so rapidly, it makes sense that more and more work is completed online. From ecommerce businesses to social media marketing, you can actually earn a decent salary by working from your computer in 2019. Not only can online work pay for your life expenses, it gives you the freedom to work from home or from across the world.
For these reasons and more, lots of individuals are deeming themselves as “digital nomads”. This term was coined several years ago in the wake of technological advancements and online-based businesses. To be a digital nomad basically means using your computer and an internet connection to earn a living – from anywhere in the world.
Sounds nice, right? As long as you have a computer and a solid WiFi connection, you can start earning money today. Here are some of the top jobs for digital nomads in 2019.
Teaching English overseas or online can actually be a lucrative position. Depending on your credentials and your hiring company, you could be earning $22-$25 USD per hour. There are tons of platforms for teaching English online, and some of them don’t require you to have any experience at all.
These jobs involve you teaching basic English skills to someone overseas (typically in China). You’ll have one-on-one (and sometimes group) sessions with your student(s) and teach over through your computer screen. The most reputable company for online teaching is VIPKID, but VerbalPlanet and QKids are also popular.
This one takes some programming knowledge, but if you have that you can start developing websites to make some cash on the road. If you have basic web developing skills you can use platforms like WordPress to create beautiful sites for your clients. You’ll be responsible for creating the layout, design style, and overall functionality of a site.
There is no major brand or celebrity out there that does not have a strong social media presence and following. Typically these popular social media accounts are managed by experts called social media marketers. A position like this involves scheduling future posts and commenting to fans and customers.
Basically a social media marketer is responsible for maintaining a brand’s reputation and keeping followers happy. Since this position requires you working for another person or company, chances are you’ll have to apply and interview to show your worth. Check out this resume summary to help you build a flawless resume for a social media marketing position.
Where do you think all of that writing content on the internet comes from? A good portion of the time it is created by a digital nomad who is working as a freelance writer. Writing content is what makes websites, social media accounts, advertisements, and much of the internet possible.
Many freelance writers are hired as SEO content creators. This means that they write informative articles for a client in order for the brand or product to rank higher on a search engine. SEO is the lifeblood of digital marketing, and the need for SEO writers is constant. Words are everywhere, and someone needs to write them… so why can’t it be you?
According to Smallbiztrends, 50% of startups fail in the first four years. A business is actualized from just an idea to a reality. The excitement of having a new venture is uncontrollable, and sometimes you want to try everything that looks like a growth factor.
For a business to be successful, it needs a lot of input and cooperation from the owner to the employees.
How do you make your startup successful?
A business plan could either make or break your business. How do you plan to finance your business? Most people have savings intended for their startups. However, you may need extra funding as your capital may not be enough.
A clearly written business plan will help you find financiers. As long as you can demonstrate how profitable the business will, you can get venture capitalists or angel investors willing to fund you.
Funds are an integral part of the business. They are a huge determinant of your business’s success. Inadequate funds could lead to bankruptcy which in turn hurts your credit score. However, there’s a way on how to remove a bankruptcy so that it does not deter you from getting future financing.
According to a survey by PWC, 59% of consumers in the U.S. will stop using a brand they love after a series of one bad experience, while 17% will be after just one bad experience. This shows how much customer service is crucial in the business. Today you could have 1,000 clients, but after the employees talking rudely to them, only a handful will return. And that is the power of customer service.
Customer service is a delicate matter which could see you make over 100% profit or 0% depending on how you treat the clients.
Invest in staff training or merely hire somebody to deal with customer queries.
If you value your clients and treat them right, they’ll keep coming back and referring their friends who will see you grow your client base.
Most people nowadays are spending more time online, and they want to find what they need quickly. Coming up with a website for your company is an excellent way for them to find you.
A website is almost a must-have tool that gives your business visibility. Make your site SEO-friendly such as making the loading speed more efficient and ensuring the content on it is relevant.
A great thought-out marketing strategy will definitely see your startup grow.
Always remember that employees are crucial to making your company grow. From the hiring process to the retention of employees, you need to have the right strategy. Hire people who share the company’s visions and objectives as they are more likely to stay.
Employee motivation should be a consideration all the time as they hold the success or failure of a business. Simple appreciation gestures such as acknowledging when they achieve a set target goes a long way in making them know you value them.
Salary increments once in a while also motivates them to even working harder as their efforts are rewarded.
Who are your competitors in the industry? What is that they do differently? What are their loopholes? Identify a few competitors you think they have made it. Scrutinize them and see if there is anything you could leverage on.
Most often, there will be something different which you could incorporate into your business. Find unique ways to relay your new product messages.
Finances should be something you always have to be keen on when making both long-term and short-term goals. Get a good accountant who can keep all the accounting records for the business. Get to know how the company is fairing on and how much profit you are making. Such information helps you make financial decisions that will propel the business.
A business requires persistence and sacrifices. Most times, you’ll have to put in more time than already existing companies especially when starting out. Be ready to spend less time with your loved ones as you create a foundation for it.
Have mentors who’ve been in the same business as yours who will walk with you through the journey. A support system helps you get back up even when you think you can’t.
The growth of a business depends on your input. The above seven tips will help you make the right decisions affecting your business.
Although a business plan is recommended for all businesses and entrepreneurs, the reality is that most small businesses only both when they need to acquire funding. Any investor or bank will require a well-researched and thorough business plan, with feasible financial forecasts and (if you’ve been running for a while) all of your existing profit and loss information.
However, a good business plan really should be something you produce even if you’re not actively looking for funding, as it can help you validate your business idea and bring into focus any challenges or difficulties you might encounter.
Similarly, a business plan can help you understand the finances of your business. Whether it’s through a complex Excel sheet with multiple years, forecasts and calculations, or a more informal list of how you expect to spend and make money. Often, entrepreneurs will be surprised by how much money they are actually going to need, and don’t discover this potentially critical problem until they sit down and complete a financial forecast. Just make sure you double check all of your data, particularly if you’re using a spreadsheet – there are numerous examples of businesses losing substantial sums of money due to a minor Excel error!
Moving away from the financial side of things, a business plan can also help you understand your market, policies and guidelines you need to follow, how you will market your product or services and, crucially, who you will market them to. The difference this can make to the overall success of your small business cannot be overstated, and it allows you to move forward with a clear plan of action. Having a roadmap and an understanding of how you will approach your business and any potential problems can be the difference between success and failure, particularly in competitive industries.
So, if you’re running a small business and you’ve never really sat down to complete a business plan, now might be the time to start. Even if you’ve been up and running for several months or years, it’s never too late to think about the future of your business. If you’re struggling, this simple guide will help you understand how to write a business plan and what you should include.
One of things that few entrepreneurs battle is disasters. The expectation is that bad things don’t happen that are sufficiently grave to warrant pre-planning to either head them off or better deal with them should they occur. However, many times a major loss of a key person at the business due to a death or a fire at the premises is enough to decimate the operation and bring the company to its knees within mere months.
Here are a few examples of mini and major disasters and how to plan for them or resolve them.
A hard drive failure on a work PC can spell disaster for whichever employee it affects. Some companies will have spare hard drives on hand and personnel who are knowledgeable to fit them, but recovering the data is another matter entirely. In most cases, unless your business has someone trained in computer engineering or repairs, then seeking out a professional service like Secure Data Recovery to assist you is a good idea.
Zero downtime with storage technology is a hot trend right now. Your best bet to achieve this is to have either a spare hard drive or a spare PC sitting ready while sending the hard drive off to be repaired or the data recovered. While not all the data may be recoverable from a damaged or worn out drive, at least some of it might be. In the meantime, ensure you have a solid backup procedure in place. This way, staff can get back up and running quickly using a backup service.
A fire breaking out at the office is not seen as a likely event, but it is often unrecoverable. Not only due to the risk to personnel and the office, but the equipment too. One of the greatest business risks of a possible fire is the potential loss of confidence with client. A serious lack of preparation causing office downtime often results in a temporary shutdown of services. The setback can be so severe that no amount of reassurance or advertising can replace the trust in the business operations after the company is back up and running once more.
There are companies that provide emergency office space within a certain number of hours to move right into. A phone service along with internet is usually available immediately. Alternatively, companies can hire a temporary office from a short-term office rental company for their employees to work in until the matter has been resolved. When there’s a fire disaster recovery plan already in place, most companies tend to survive an unexpected fire; ones that have no plan often fold soon after.
The loss of a key person from the business due to a death is a sad event that affects a company profoundly. It can be the CEO or a President or Vice President, with their loss affecting the ability of the company to survive. Finding a suitable replacement tends to take longer the more senior the position.
To protect against the loss of someone important, insurance companies offer key person insurance to businesses which is essentially life insurance cover for companies. Covering the people who are crucial to the business with a substantial payout to the company should they die unexpectedly, provides time for the company to recover and replace them with someone suitable to keep the company alive.
It’s possible for an entrepreneur to protect their business if they plan well. Covering the sudden loss of key personnel, a technology failure or fire at the premises requires not ignoring each potential problem and addressing it before it ever happens.
Everyone can take photographs, but not everyone can take great photographs. Photography is a skill which is learned, and although there are some who are innately talented, even these individuals need to have their talents harnessed and enhanced in the proper way. If you have an eye for photography and would like to be a great amateur photographer or establish a career as a professional photographer, adequate training is important. But there are certain things you can do to help you on your way, too. Here are some top tips for photography beginners: what you should know.
As a photography beginner, you are probably inspired by things you see everywhere around you. And this is why it’s important to bring your camera with you at all times. You never really know when inspiration will strike – it could strike when you’re walking down the street, it could strike whilst you’re having supper, and so on. There are many opportunities to hone your craft, and the best way to improve is to take as many photographs as you can.
If you can’t bring your camera with you all the time, there’s another thing you can do: note it down. When you are outside or at work, bring a notebook with you so you can note down the different things you see which you might want to go back to when you have your equipment. You should also note down the different aspects such as the lighting (when is the best time of day to come back?), the weather, the crowd, etc. By doing this, you can go back to something that inspired you, take proper photos, and eagerly await the results.
Learning to be a good photographer involves being inspired by everything around you. Look at your surroundings with a ‘photographer’s eyes’ and you’ll see the most ordinary, mundane objects turn into objects of inspiration. Enjoy the process of learning – even the most skilled and veteran photographers will tell you that they enjoy learning something new every day. It’s an art, after all, and the only way you can produce something great is if you enjoy it and are passionate about it.
An amateur considers a professional camera a delicate piece of equipment – and it is. But you will need to learn how to be comfortable with your equipment, so don’t be afraid to experiment, particularly when it comes to the settings of your camera. Go through the manual and take photos using different settings so you can see what you like and what works for your style.
If you are serious about enhancing your skills as a photographer, you should take advantage of whatever resources are available. Take the right photography courses for beginners, so you can learn how to use your equipment properly and learn about basic elements that make up great photography, such as exposure, light, depth of field, composition, and so on. By knowing these aspects, you can at least broaden your knowledge about your favourite hobby (or, eventually, profession if you so choose).
Many people dream of starting their own creative company, and the good news is this: with the right mindset and a bit of hard work, it’s definitely possible! So whether you’re into craftwork and needlework or you’ve got ambitions to open your own studio, there are all sorts of creative entrepreneurship choices out there. Check out these top tips and take them on board to make your journey towards creative self-employment as easy as possible.
It’s quite common for people to say that they’re “not creative” or that they “don’t have a creative bone” in their bodies. But in truth, everyone has a creative skill of one sort or another. Some people find that they can sit down at an easel and paint a gorgeous picture without having to really try. Other people have an amazing idea for a novel in their heads, and once they sit down and write it becomes the next big bestseller. Others, even, find that they’re always getting compliments about their cooking, and once they open their own restaurant their innovative recipes are great hits.
It doesn’t matter what you’re good at: everyone has something creative that they can do. The secret to success in the world of creative entrepreneurship, though, is locating what it is that you can do and how you can monetise it. If you choose the wrong talent or you fail to choose a talent at all, there’s no chance of success.
When it comes to launching a creative business, the financial aspect might not be the most interesting thing to think about – but it’s the most important. Without an adequate funding system in place, it may not be possible to get the cash you need to buy or lease equipment, hire essential staff or cover your living costs before you break even financially. There are various sources of start-up funding that you can go for. Investors will provide up-front cash, but they can be hard to come by and are likely to also demand ownership of a portion of your firm.
Other alternatives include bank loans, funding from family and friends, and “bootstrapping” – where you cut your costs so low that you don’t need the help of outsiders. Of course, you can always play the lottery and hope your numbers come up! It might be a long shot but there’s nothing like the anticipation buzz of checking all of the California winning numbers to see if you have the CA lottery winning numbers. It’s a hope that can prompt you to start dreaming big for your business and, who knows, maybe it will get your creative juices flowing.
One of the most complex areas of law is the intellectual property sphere. There are all sorts of rules and regulations surrounding what can and can’t be patented as your own work, but in theory if you create something (which, let’s face it, you will certainly have to do as a creative entrepreneur) then it is your property and nobody else’s.
With the help of a specialist lawyer, you may find that you are able to secure this in law and enjoy the benefits that brings. You can maximize your chances of a successful IP case by keeping as many drafts, documents and other items you produce as possible and finding a way to get it all dated so that you can verify the process you went through in any future legal case.
The fantastic thing about a creative business is that it can often be built and scaled from a small starting point. If you’re not quite ready to give up the security of a pay check just yet, why not go part time or simply work on your creative business outside of your full-time work hours? Even by devoting an hour a day to your business, you can enjoy both the security of your job and the satisfaction your business gives you until you get to a point where your business can cover your living costs.
In the end, your business is only going to go one of two ways – towards success, or failure. Entrepreneurs instinctively know when things are working out and when they’re not, and it’s essential for you to develop the skills needed to recognise the signs. If things don’t work out as you’d hoped, it’s time to face up to the truth and change your course – either to a new creative endeavor which works out better, or to something else altogether.
Starting up on your own can sometimes seem like a scary business, but that doesn’t always have to be the case. By following our top tips for creative business success, you too can join the ranks of people who are developing a side hustle or a full-time project of their own. Where will your powers of creative entrepreneurship take you next?
You might think of photographers as people who take pictures at weddings and schools or as part of an elite, jetting around the world photographing catwalk models and media stars. Then there’s the paparazzi, lurking about wherever they might get a juicy snap of a celeb in a compromising situation. There is in fact far more to being a photographer, and there are many niches that it is possible to specialize in. With the rising demand in picture media for advertising and the internet, the prospects of being able to make a living out of photographing your favorite things are very good.
Sport photography could be considered a niche in itself, but a lot of photographers concentrate on one type of sport, such as ball games, swimming or equestrian sports or even exclusively on one individual sport. Live action shots are always popular, but there’s plenty of scope for mood shots, training, views of sports fans, the stadium or location of the event, family members and friends, famous visitors and so on. Having an understanding of the game and what will be of most interest to people is a necessary attribute of the sports photographer. A food photographer doesn’t need to be a chef in order to take stunning pictures, but for sports, the photographer needs to be familiar with the rules, tactics, and participants to take the best photos.
Publishers are always in need of expertly shot food pictures, given the popularity of cookbooks and the proliferation of food-related websites. Good quality, well-structured photos that make the food look mouth-wateringly delicious are key to capturing peoples’ attention. Some food looks and sounds so good it is a joy to photograph, like the blueberry pancakes at Pocket Change Gourmet. Other dishes can be a little more challenging, for example, there is a huge appetite across the world for insects as food, but how would you photograph dishes made from crickets or mealworms to make them look appealing to a Western audience?
The travel industry is a massive business, and it’s expanding all the time. Travelers are looking for new and exciting places to visit, cityscapes are changing all the time, new hotels and resorts are being built, and alternative styles of vacation are being launched on a regular basis. Then there are the activities, facilities, restaurants, native flora and fauna, local people, tourist landmarks that can be taken as travel photography. All these aspects need to be photographed for websites and brochures, and regularly updated to reflect the most current appearance of a location. There is also the transport side of travel; airlines, cruise ships, car rentals. The list of associated opportunities is long and varied.
If you have a passion for a subject and some knowledge to match, then using your photographic skills to capture the action and take photos that inspire and move people can be a very rewarding career. Whether your passion is for archaeology, rare mammals or car engines, there will be someone who needs photos of those things, and if you have specialist skills, your work could be very valuable.
Is It Really Possible To Make Money From YouTube?
The internet has provided a convenient and easy to use platform for sharing content and making money. Just about anything can be monetized if there is a willing audience. Content creators have constantly found new opportunities for making money from platforms such as YouTube. Most people are aware that there are now individuals who have become millionaires on the backs of their YouTube videos, but how exactly are these videos turned into cold, hard cash?
Making money on YouTube sounds easy and straightforward. You post some videos, attract millions of viewers, and cash out on the huge ad revenue. The actual process is a little bit more complicated than this and it isn’t nearly so simple and painless. If it really were that simple, everyone would be making their money on YouTube! The reality is that YouTube isn’t a get-rich-quick scheme and you will need time for your channel to gain subscribers.
Advertisers are certainly willing to pay a decent amount of money to promote their products and services through YouTube, but even so, only a portion of the money that they spend will go directly to the content creators. The majority of the funds will be taken by YouTube themselves. Because of this, if you want YouTube to become the source of a full-time wage for you, then you will need to be one of the most viewed channels on there. Fortunately, however, advertising revenue isn’t the only way of making money from YouTube.
YouTube is a powerful marketing platform, especially for small businesses, and it provides an excellent way to sell your products and services to an audience. It is now incredibly easy to set up an e-commerce website. In fact, it requires absolutely no prior knowledge of web design or coding. There are now a number of services, such as Etsy and Shopify, which allow anyone to easily sell their products over the internet.
By using your YouTube videos as a means to advertise your products to consumers, as well as giving them first-hand demonstrations of them, then it is easy to use the site to drive up your own sales.
Just as you can now easily sell products on the internet, it is also easy to sell on-demand media content such as videos. Using these services, it is possible for content creators to make money directly from their videos and to not have to depend on indirect methods such as advertising through YouTube. YouTube videos can be a very effective means of building up your brand’s reputation. Once you have made an impression on YouTube, you can then direct viewers to visit your main site or store.
If you are planning on selling videos, then they need to be of superb technical quality. Check out indreviews.com for reviews of webcams and other tools necessary to YouTubers success.
Making money from YouTube is far from easy, especially if you are hoping for the kind of revenue that will replace a normal, full-salaried job. However, it is definitely possible to make money directly through YouTube, as well as taking advantage of the possibilities that it offers such as, being able to travel and work, as a way of promoting other businesses and interests that you might have.
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Get them while they’re fresh! Hot, horny, and just the way God made them. These all natural girls are eager to please a man like only a young girl can!
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Giving is not just about making a donation. It is about making a difference."
When you can't put your prayer into words, God hears your heart.
Lord, Make my life a window for your light to shine through and a mirror to reflect your love to all I meet. Amen.
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Pursuing for The Program 7 Book Series Ebook Download Do you really need this book of The Program 7 Book Series Ebook Download It takes me 13 hours just to get the right download link, and another 7 hours to validate it.... The Reedsy Book Editor is a free online writing tool allowing any author to format and create professional ePub and print-ready files in seconds. The @ReedsyHQ Book Editor allows you to write, format, edit and export � for free!
Writing Skills, by Diana Hanbury King, is a comprehensive writing program for beginning, struggling, at-risk, or reluctant writers. For these writers, this structured program � effectiveness of internal control system pdf Adobe� Lightroom� users have a Blurb-powered book creation tool built right into the program. Our Book module lets Lightroom users make a gorgeous photography book without needing to leave the Lightroom workflow.
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Download Advice To The Writer written by Stephen Koch and has been published by Modern Library this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-25 with Reference categories.
Adobe� Lightroom� users have a Blurb-powered book creation tool built right into the program. Our Book module lets Lightroom users make a gorgeous photography book without needing to leave the Lightroom workflow.
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Service Manual Chery Tiggo is good choice for you that looking for nice reading experience. We hope you glad to visit our website. Please read our description and our privacy and policy page.
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Austrian Crystal Angel Pins Each with goldtone accents. Each piece bar coded. 1/2"
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His self less sacrifice to do his targets actually indicates that Martin Luther King Jr among the most courageous men as well as women in history. Courage is an extremely commended characteristic in some one. The bravery to accept that reality is possibly the only lasting one we’ll locate. Courage remains used by political inspiration. It’s a several -faceted quality and you will find several ways in which you can compose about it. It is probably one of the most important characteristics in a guy because without it he WOn’t manage to show his other merits. It really is one of the characteristic that may set a person besides the rest of the folks. I’ve noticed that sometimes it can require bravery to merely awaken and initiate the evening clean. It demands courage to touch diverse folks’s lifestyles collectively with permit yours be handled.
Physical bravery relies on one’s physical strength. You can purchase essay written from scratch for you, purchase an essay being re written, purchase composition on-line editing or proofreading. Buying essays is substantially simpler task as compared with essay conclusion for sure. For those who have ever employed essay composing services, you will be below the perception it charges a good deal. Thus, you should find someone to assist you do your paper. You won’t ever discover such a fantastic strategy in any entirely free paper in the internet. Every study should confirm its foundation, and that is where that is completed, even whenever foundation for the research is that tiny other investigation in the special location was done. Nevertheless, it didn’t, clearly, any more than an absence of wings announced cowardice.
Public careers offer the class with an interesting and educational alternative.
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It doesn’t make a distinction what it’s dieing for the lifetime of someone else or getting money to cover the children instruction. With the absolutely free accessibility to the live chat, you’ve got an exclusive chance to keep in touch through your writer any moment during the approach. It is simply too crucial to spend less about it. Let’s look at the many distinctive characteristics of courage. It is not feasible to hand in a plagiarized paper whenever you’re a postgraduate. He’s a guy of fantastic integrity and intelligence. Barely any guys on earth receive the Nobel Prize for Peace. To the contrary, it is something which an individual develops over a time period Completely any man or woman can purchase essay from expert writers. Being a terminally patient and knowing your ending is close could force you to create the guts to have the inevitable.
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Bluestone Paver Guys in Weslaco, TX is a team of professionals who have the necessary knowledge, experience and expertise in providing its customers around the Weslaco, TX with all kinds of services on Bluestone Pavers. Our service providers have been in business for a very long time and have gained the necessary experience that enables the Bluestone Paver Guys to still be the number one Bluestone Pavers service provider around Weslaco, TX.
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I’m so pleased that I found a key lime pie recipe that doesn’t involve excessive amounts of condensed milk. In fact, this one is primarily made out of Greek yogurt, a protein-packed powerhouse. I had a tub of Greek yogurt sitting in the fridge, and as I perused the weekly circulars, I saw that limes were going on sale at 5 for $1. (This is how I generally decide what to make. a) what I have in the pantry; b) what I can buy cheaply.) I put two and two together, and brainwave – I shall make a key lime pie! I did some digging around, and found this recipe from Obama Foodorama, a blog dedicated to the food initiatives of the White House. No surprises that they found a way to make a healthier key lime pie!
I didn’t actually use key limes, but regular limes worked fantastic too. I really enjoyed the simplicity of the recipe. A lot of key lime pies require some kind of artificial or unhealthful ingredient, like gelatin, sweetened condensed milk or key lime-flavored yogurt – but the stiffer texture of Greek yogurt was sufficient to hold the filling together. I also invented a crust made out of an unconventional ingredient – not graham crackers, but bran flakes. I know, bran flakes in your pie crust might sound a little suspect, but with the addition of butter and sugar and a quick bake in the oven, it came out caramelized with a nice toothsome chew. You’re not going to mistake it for a graham cracker crust, but it held its own against the smooth tangy creaminess of the pie filling.
2. Stir bran flakes crumbs, sugar, and butter in a bowl until combined. Then press mixture evenly into bottom and up the sides of a 9″ pie plate.
3. Bake crust 10 minutes, then remove from oven to cool.
1. Whisk together yogurt, egg yolks, honey, and sugar; add juice and whisk until well combined.
2. Pour filling into crust, and bake for 20 minutes in 350°F oven (mixture will not be firm).
another recipe i found recommended *freezing* the pie (and keeping it in there) — you could try that and see if it ended up being more like a frozen yogurt pie..?
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Our band Silence was formed in 1990, today we are: Nadja & Thomas Lauwiner (voc), René Eberhard (bass), Michael Röthlisberger (keys), Alex Strässle (perc), Stephan Streit (flutes, guit) und Fritz Rentsch (Mix) We created many original compositions in the first ten years of the band’s history and performed these songs in concerts and on three CD releases. Biblical messages were always a theme of our lyrics and continue as our main theme even now.
After a 14 year break, our band reunited. We began to score Psalms into music, thereby achieving a long held aspiration.The process of making each composition that we scored, brought us closer to the Psalms, and each became a spiritual gift. We found that the words of the Psalms, as translated in the English Standard Version, proved to be a perfect fit between musical phrasing and the structure of the lyrics, allowing us to express harmony and melody in our compositions. With the scoring of Psalms we want to carry on their original message to show relevance to our modern time. In doing so we would like to work in the service of the Most High and His Word. It is our hope that, through our musical interpretation, people will discover the wealth of wisdom which the Bible holds, especially the Book of Psalms.
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Enjoy Your FREE AUDIO Lessons Below!
Gratitude Daily is a 21-day audio journey to help you build your gratitude skills through science-backed practices. Each day, you'll receive a 10–15 minute lesson that will help you experience more joy and less stress right away—plus, you’ll build resiliency for when times get tough.
You can cultivate a nourishing and sustainable gratitude practice without radically changing your life.
Most of us have heard about the benefits of gratitude. It’s been shown time and again to be a critical ingredient for a happy, healthy life. But actually remembering to be grateful is another story . . .
The thing is, the more you practice your gratitude skills, the better they work—little acts of gratitude each day have a much bigger impact on your overall well-being than the occasional big event.
This is why Gratitude Daily brings you short, fun lessons every day for 21 days. By the end of the journey, you’ll not only have created a solid gratitude habit, you’ll have actually changed your brain in ways that bring you more joy, better health, and greater resiliency going forward.
”Gratitude isn't a feeling you get from something outside of you—it's a skill that you can learn and improve through regular practice.
Your guide on this journey is world-renowned happiness expert Nataly Kogan.
Nataly is an entrepreneur, speaker, and the founder and CEO of Happier—a global learning platform that has helped more than 1 million people live happier lives.
Nataly is the author of Happier Now: How to Stop Chasing Perfection and Embrace Everyday Moments (Even the Difficult Ones). Her work has been featured in hundreds of media outlets, including the New York Times, the Wall Street Journal, TEDx Boston, SXSW, the Harvard Women’s Leadership Conference, and The Dr. Oz Show.
My life’s mission is to help you find more joy in everyday moments and get through difficult ones with compassion and resilience.
What I've learned—both through research and working with tens of thousands of people from all walks of life—is that genuine emotional well-being doesn't come from making everything in our lives perfect. It comes from allowing ourselves to feel all that we feel and accepting ourselves and the world as best we can. Then, from that as a starting point, we can practice skills like gratitude to experience more moments of joy, connection, kindness, and beauty in our daily lives.
Happiness isn't something you feel—it's something you do. It's a skill you can improve through practice, and gratitude is the single most powerful, impactful, and essential skill to cultivate for lasting emotional well-being.
I’m dedicated to helping you make simple-yet-profound science-backed gratitude practices part of your daily life—and to have fun while you do!
A regular gratitude practice really does make you healthier, happier, and more resilient—and a growing body of research tells us exactly why.
Thanks to our inherent “negativity bias,” our brains are overly focused on negative experiences. When you make gratitude a regular part of your day, you train your brain to notice the good in your life—and being happier becomes a habit!
The connection between stress and sickness is well documented—and these days, we’re pretty much always under stress. Luckily, gratitude is a science-backed way to reduce stress and keep you healthy.
Several studies have linked gratitude with resilience. By making a conscious choice to focus on something positive even when things may be challenging, you develop more strength to get through whatever life may bring your way.
Gratitude works—and it works best when you do it every day. Most of us know it’s good for us, but we only experience the benefits if we actually practice.
” You’re not failing at happiness because you feel sad or angry. Let yourself feel what you feel, but don’t lose sight of the little moments of beauty that are always there, even if you have to wipe away your tears to see them.
Gratitude Daily is a 21-day journey to bring more gratitude into your life so you can feel happier, healthier, and more resilient. Each day you’ll receive a 10–15 minute lesson introducing a new gratitude practice. By the end of your 21-day journey, you’ll have a wealth of resources for living a life of gratitude and joy.
Part 1 of this program introduces you to science-backed gratitude practices that are especially useful for days when you feel stressed out, frustrated, or just not in a good mood. These practices aren’t about telling yourself to feel happy when you really don’t—they’re proven techniques to bring you greater well-being even when you’re going through challenges, change, or uncertainty. You’ll learn how to ease your daily stress and increase your resilience for the really tough times.
Part 2 begins your shift into a full-on attitude of gratitude. Here, you’ll explore how to integrate gratitude into your everyday life, learning little practices to do throughout each day. These practices are designed to become daily habits, so no matter how busy or distracted you get, you’ll naturally and effortlessly experience feelings of gratitude and joy. Most of them take just a few minutes!
In Part 3, you’ll strengthen your relationships through gratitude. Time and again, our relationships with others are shown to be some of the most important factors for our happiness and health. As you practice expressing gratitude to others, you’ll begin to feel a greater sense of human connection. You’ll see your relationships improve, feel more supported, and notice your own state of well-being grow even stronger.
In Part 4, you’ll turn toward your relationship with yourself. Many of us think that if we’re not hard on ourselves, we’ll get lazy or self-indulgent. But the truth, according to countless scientific studies, is that self-compassion actually increases motivation and helps us live happier and more productive lives—and gratitude is a wonderful way to create a kinder, more compassionate relationship with yourself.
Part 5 will help you expand your gratitude practice so you begin to see the world through a gratitude lens. You’ll practice noticing the beauty, kindness, and goodness that already exist all around you and begin to feel more in harmony with all of life. The culminating sessions in your journey will leave you feeling literally more appreciative of your blessings and inspired to continue living with a grateful heart.
I feel this gratitude course is helping to improve not only my happiness but also my life! Almost all aspects of my life have improved . . . I feel closer to friends, family, and my partner.
I wanted to thank you for reminding me that gratitude and happiness aren't just random emotions we sometimes feel, but choices in how to live.
[Gratitude] changed my entire outlook on everything—I don't worry as much, I sleep soundly, and I'm a much more positive person now!
Begin your Gratitude Daily journey today!
We unconditionally guarantee your satisfaction with all Sounds True products for one year when purchased via our website. However, if you are not 100% satisfied for any reason, simply return it with receipt for a full refund.
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You can access the gifts here.
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|
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Williamsburg is a perfect destination for families to combine fun with a little bit of learning. The area is filled with outdoor activities to keep your kids engaged and entertained.
Watch history come alive in the Historic Triangle’s biggest draw, Colonial Williamsburg. Walk through the colonial village, interact with townspeople in authentic dress, and watch daily colonial life unfold in front of you. It's a short drive to see more living history at the Jamestown Settlement, where you can explore the original colony complete with reproductions of the ships and the colonists' fort. At the Yorktown Victory Center, relive the final days of the Revolutionary War through a soldier’s eyes at a recreation of a Continental Army camp site.
If you prefer your history a little less "alive," check out the renovated Bassett Hall and accompanying gardens in Williamsburg, once home to John D. Rockefeller Jr. and his wife Abby. Moore House and Nelson House in Yorktown offer additional insights into our colonial roots. Historic Jamestowne, where the first Europeans settled in the New World, is a great place to watch history in action as archaeologists unearth more of the original settlement every day. These sites are perfect for older kids, who may be a little skeptical about the living history parks, to learn about the area.
If you need a special treat for kids who are desperate for some more modern entertainment, Williamsburg has plenty of solutions. Stretch the educational experience a little bit further at Busch Gardens Williamsburg, an amusement park with an Old World European theme to go with its roller coasters. To cool off in summer, Water Country USA refreshes families with slides, rides, and pools. Great Wolf Lodge is open all year with a water park, arcade, bowling, mini-golf, and fantasy-themed kid adventures. The Lodge also offers on-site accommodations, including cabin-themed suites for the family.
Take some time out to explore nature on the array of scenic walks and bike trails around the Historic Triangle. Take the Island Loop Drive surrounding the Jamestown Rediscovery Project for beautiful views of marshlands, the James River, and the original settlement. Head over to Freedom Park for a multitude of hiking and biking trails, in addition to beautiful scenery and places of historical interest. Don’t forget to wander down to the campus of William & Mary College, which hosts ten miles of trails on campus and in the accompanying College Woods.
Thanks to its proximity to both the James and York rivers, there are plenty of water-related adventures to enjoy on your vacation. Rent a kayak or canoe at James City County Marina to explore the riverfront around the Jamestown settlement. In Yorktown, head over to the Riverwalk Landing Marina to experience the historic flair of the waterfront on one of the tall-ship cruises on the Alliance and Serenity schooners. Try your hand at manning the sail, or simply relax as you breathe in the sea air. Delight the kids with a pirate cruise by Yorktown Sailing Charters, where they learn all about local pirate lore while helping to sail the ship.
Immerse the family further into the world of the 1700s with kids' costume rentals at the Colonial Williamsburg Regional Visitor Center. Authentic reproduction dresses and hats (as well as complete adult ensembles) are available at many shops inside Colonial Williamsburg. While you’re there, stop into the William Pitt Shop for historical games and toys, or visit the Market House, which sells toys, hats, costumes, and more. Finish up at Merchants Square's Wythe Candy & Gourmet Shop for homemade fudge, candied apples, and every other sugary delight that you could ever want.
If you want to soak up the picturesque scenery without tramping through the great outdoors with your family, try one of the area’s many scenic drives. Take Colonial Parkway, which connects Yorktown, Jamestown, and Williamsburg and winds through places of historical significance and natural beauty. Jamestown’s stunning Island Loop Drive has plenty of areas to pull off the road and snap pictures. Or take one of the two self-guided driving tours of the Yorktown Battlefield; informational brochures and maps are available at the Yorktown Visitor Center.
Take a break from all the history with a little outdoor adventure. Swing from the treetops with Go Ape Treetop Adventures, a rope-swing and zip-line course in Freedom Park. They have an advanced course for adults and a junior course for the kids, so the whole family can get a thrill high above the ground. If you're feeling the need for speed, race around the tracks at Go-Karts Plus. For more low-key fun, try a mini-golf course. Choose your favorite theme, and either enjoy a 30-foot-high waterwheel at Gold Rush Miniature Golf (in the Go-Karts Plus park), or walk the plank at Pirate's Cove Adventure Golf.
For a rainy day—or for more in-depth explanations of history—Williamsburg has a few historical museums that are worth checking out. The Nathalie P. & Alan M. Voorhees Archaearium displays findings from the ongoing historical dig. Find out what the experts have unearthed about the real Pocahontas, the earliest settlers, and colonial cannibalism! The Historic Jamestowne Visitor Center Museum is a great place to learn about the original settlement, and the Watermen’s Museum in Yorktown is dedicated to the Chesapeake Bay sailors that defended the nation and worked the waters.
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ORDER TAB WAS TAKEN DOWN ON DEADLINE DATE.
THANK YOU FOR YOUR BUSINESS & HAVE A GREAT SEASON!
2XL & UP HAVE EXTRA FEE.
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Ventura, CA -- (SBWIRE) -- 01/4/2006 -- 21st Century Associates, LLC. (21st Century) signed a non-exclusive agreement with FranTech International Licensing, Inc. (FranTech), of Ventura, California, which grants FranTech the right to market 21st Century's growth assistance programs through FranTech's network of agents in 220 countries to governments around the world.
The company explained that the 21st Century’s growth assistance programs are uniquely suited to meet the needs of emerging growth companies in most countries. 21st Century has been in the business directly and indirectly assisting emerging growth companies, both domestically and internationally.
J. Michael Valo, President of 21st Century, said, "We chose FranTech because of their tremendous geographic reach and proven track record in establishing licensing agreements. With more than 35 years of experience, FranTech knows international trade policy, law, marketing, investment banking, and technology research. Its broad expertise, coupled with access to key governmental decision makers, provides services uniquely valuable to 21st Century overseas."
Philip Nadeau, CEO of FranTech, said, "We see a tremendous market worldwide for assistance programs for emerging companies and already have interest from several countries. We plan on developing brand name recognition and positioning of 21st Century with many governmental agencies where we already have relationships in place."
21st Century’s programs aid in assembling a team that has the ability of taking a company from initial formation to the growth and status that they cannot achieve alone.
21st Century’s strength lies in its organizational, developmental and analyzing abilities. The company has arranged and assisted in funding of over 50 million dollars. The fields most directly included are communications, energy and the marketing of consumer products thru all forms of media exposure. 21st Century is uniquely positioned to address the worldwide needs of developing nations economic development as well as the business growth needs of industrial nations around the world.
About FranTech International Licensing, Inc.
FranTech consists of core partners surrounded by interlocking networks of consultants and affiliates in key trading countries and disciplines. They have over thirty-five years of experience with their proven partners. In addition, FranTech has proven track records in assembling, negotiating and consummating trade, licensing, technological and financial agreements; they pool strengths drawn from experience in international trade policy, law, marketing, investment banking and technology research. This broad expertise, coupled with access to key governmental and business decision makers, provides services uniquely valuable to 21st Century in the restructuring global economy. 21st Century is pleased to commence a strong working relationship with FranTech.
FranTech’s mission is to foster the development of the Global Economy by providing a Global Perspective to developers, marketers, manufactures, and innovators of newly emerging and preemptive technologies. They offer world-class solutions for the licensing and transfer of USA innovations to emerging economies in 220 countries worldwide for over thirty-five years.
For information on this exclusive technology contact FranTech at (805) 653-5264.
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Source: FranTech International Licensing, Inc.
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{
"timestamp": "2019-04-22T02:27:13",
"url": "http://www.releasewire.com/press-releases/release-4750.htm",
"language": "en",
"source": "c4"
}
|
The Long Awaited Performance Plug-In Hybrid Unveiled in Malaysia.
Following the Malaysian launch of the updated BMW i8 Coupé last August 2018, BMW Group Malaysia has also unveiled the First-Ever BMW i8 Roadster a month after (last September 2018), in conjunction with the Conference of the Electric Power Supply Industry (CEPSI) 2018, at which BMW Group Malaysia was the official E-Mobility partner.
Conceptualised and unveiled as the BMW i8 Concept Spyder in 2012, the BMW i8 Roadster is an open-top 2 seater sibling to the BMW i8 Coupé with main differences being the roof section, the +2 seating at the rear section of the coupé and the coupé/roadster design lines of the rear section. Visual difference is noticeable immediately by looking at the C-pillars, where the designation of either "Roadster" or "Coupé" will be in place.
The +2 seats of the coupé were cleverly traded in for approximately 92 litres of additional storage space. When opened, the Roadster's broad roof retracts fully into the rear end - where a unique mechanism allows the soft-top to be folded into a compact package and stowed away in a perpendicular position. The electric roof opens and closes quietly in 15 seconds, a process which could be initiated while travelling up to 50 km/h.
Dropping down the roof raises the rear window by around 30 millimetres where it also serves as a wind deflector that reduces turbulence for the occupants. The height of this fully retractable rear window can be varied as desired by just a touch of a button.
The designers at BMW i were also able to retain the Coupé's distinctive dihedral doors for the Roadster, designing new frameless units made from carbon fibre reinforced polymer (CFRP) overlaid with aluminium while the windscreen frame is made entirely from CFRP. With CFRP, which is an ultra-strong high-tech material, the rigidity of the car is of exceptional strength but without the weight load, and this further maximises the car's occupant's protection. The BMW i8 Roadster is only 60kg heavier than the Coupé at 1,595 kg, which is a remarkably low figure for an open-top vehicle.
The other improvements and upgrades, which were made to the updated BMW i8 Coupé were also reflected on the BMW i8 Roadster. These includes the improved plug-in drivetrain with bigger EV range - increased output by 9 kW to a total 105 kW and EV range extension to 53 kilometres.
The combined system output of the BMW i8 Roadster produced by both the electric motor and engine acting in unison has also increased to 275 kW or 374 hp - and accelerates from 0 to 100 km/h in just 4.6 seconds, just a mere 0.2 seconds shy of the BMW i8 Coupé sibling.
As for the interior cockpit area, the BMW i8 Roadster spots similar layouts and improvements as the BMW i8 Coupé - which could further be read here.
The BMW i8 Roadster is available in the signature E-Copper with Accaro interior design at all BMW i dealerships with a retail price (on the road, without insurance) from RM 1,508,800.00.
With the Balloon Financing Plan from BMW Group Financial Services Malaysia, the New BMW i8 Coupé can be owned with monthly instalment plans starting from RM 17,268.00 (based on estimates of an 80% loan on a five-year tenure).
• BMW 5-Year Unlimited Mileage Warranty with Free Scheduled Service Program.
• BMW 2-Year/ 24 Month Tyre Warranty Program for its Run Flat Tyre offering and services.
• BMW Roadside Assistance and Accident Hotline.
• The BMW Group Loyalty+ Mobile App - BMW White Card.
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{
"timestamp": "2019-04-21T06:47:45",
"url": "https://thegridasia.com/refuel/the-new-bmw-i8-roadster-in-brief",
"language": "en",
"source": "c4"
}
|
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