The full dataset viewer is not available (click to read why). Only showing a preview of the rows.
The dataset generation failed
Error code: DatasetGenerationError
Exception: ArrowInvalid
Message: JSON parse error: Missing a closing quotation mark in string. in row 116
Traceback: Traceback (most recent call last):
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 145, in _generate_tables
dataset = json.load(f)
File "/usr/local/lib/python3.9/json/__init__.py", line 293, in load
return loads(fp.read(),
File "/usr/local/lib/python3.9/json/__init__.py", line 346, in loads
return _default_decoder.decode(s)
File "/usr/local/lib/python3.9/json/decoder.py", line 340, in decode
raise JSONDecodeError("Extra data", s, end)
json.decoder.JSONDecodeError: Extra data: line 2 column 1 (char 5973)
During handling of the above exception, another exception occurred:
Traceback (most recent call last):
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1995, in _prepare_split_single
for _, table in generator:
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 148, in _generate_tables
raise e
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 122, in _generate_tables
pa_table = paj.read_json(
File "pyarrow/_json.pyx", line 308, in pyarrow._json.read_json
File "pyarrow/error.pxi", line 154, in pyarrow.lib.pyarrow_internal_check_status
File "pyarrow/error.pxi", line 91, in pyarrow.lib.check_status
pyarrow.lib.ArrowInvalid: JSON parse error: Missing a closing quotation mark in string. in row 116
The above exception was the direct cause of the following exception:
Traceback (most recent call last):
File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1529, in compute_config_parquet_and_info_response
parquet_operations = convert_to_parquet(builder)
File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1154, in convert_to_parquet
builder.download_and_prepare(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1027, in download_and_prepare
self._download_and_prepare(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1122, in _download_and_prepare
self._prepare_split(split_generator, **prepare_split_kwargs)
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1882, in _prepare_split
for job_id, done, content in self._prepare_split_single(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 2038, in _prepare_split_single
raise DatasetGenerationError("An error occurred while generating the dataset") from e
datasets.exceptions.DatasetGenerationError: An error occurred while generating the datasetNeed help to make the dataset viewer work? Make sure to review how to configure the dataset viewer, and open a discussion for direct support.
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� Tuesday Overnight Open Thread (12/12/17) | Main | Mid-Morning Open Thread �
The Morning Report 12/13/17
Good morning kids. I'm old enough, and by now should be wise enough, to understand what happened yesterday in Alabama, and yet I'm still shocked and sickened. I suppose that is the normal reaction if we were living in anything resembling normal times; obviously we're not. A Senate seat in what is arguably a solid red state has been "stolen" and made Democrat. The word stolen has multiple meanings in this context and I think virtually all of them are correct (pending the whereabouts of Al Franken's Buick LeSabre, fraud will not be considered - yet).
Let's face it; electoral politics as we have known it is gone. If we didn't realize that certainly by last November, we never would have. The election of Donald Trump has thoroughly exposed the corruption, criminality and rot that is our government, media and culture. They will not allow that to stand. I can't say whether we would have witnessed the spectacle of the last few months had the candidate been Luther Strange or Mo Brooks. But, idiosyncrasies or not, Roy Moore is a lightning rod and even worse, a staunch supporter of the President and avowed enemy of Mitch McConnell and the Establishment. And so yesterday is just another indication that we are in a war between those who want to subjugate this country and citizenry, and the rest of us who want to somehow try to save it and our posterity from extinction. Yes, our enemies will crow, strut and preen about the significance of this "victory" as proof positive of the repudiation of the President and the first step towards his downfall. To which I say "go to Hell."
From a practical standpoint, Moore is not conceding and in all likelihood will demand a recount. Slim as the margin seems to be as of this writing, I have my doubts that he can overcome it. McTraitor also is saying that Doug Jones won't be seated until next year, so he will not be voting on legislation, most crucially the Tax Reform bill, and whatever else may be up for a vote between now and then. On the plus side, he's only there until 2020 but on the downside, losing that seat to a hardcore Leftist leaves only a wafer-thin majority in the Senate. And of course with Republicans like Collins, Murkowski, Alexander and too many others, well, you get the picture. And speaking of raw sewage, Richard Shelby.
Predictable: Steve Bannon (PBUH) is being attacked and mocked for causing Moore to lose the election. And yet the same momzers dumping on Bannon are the ones who not only refused to support or defend Roy Moore but actively participated in his defeat. The chutzpah is just beyond belief.
Prediction: Gloria Allred and her clients who accused Roy Moore will completely disappear from the news cycle within a day or so. Allred though will no doubt be back as what yesterday was is the opening salvo in the new/old strategy of Mish-Grabber-Gate 2.0. We can see that the Russian collusion angle has failed and the Mueller probe is going to go the same route with the revelations about Strzok, McCabe, Rosenstein and probably Adam Schiff. Oh, hell yes. It's a war people. It's a goddam long, bloody war and there will be pain inflicted on us. Let us steel ourselves and move forward.
In other news, Minnesota's governor Mark Dayton is supposed to name a replacement for Al Franken's senate seat. All well and good except Franken has not officially quit. Meh, with Moore losing Alabama, he has no excuse to stick around. And speaking of rape, New York restaurateur Ken Friedman allegedly has a rape room in an eatery that he co-owns with entertainer and former crack dealer Jay-Z. Were I not so utterly disgusted about the election, I'd have something snarky.
Lastly, J. Christian Adams talks about what's been going on at the DoJ aside from the somnambulant proclivities of its director. As I've said before, unless Sessionzzzzz personally leads the Clintons, Obama and Soros in leg irons to the paddy wagon, I can't think of a better replacement than Adams to run that agency.
Chin up people. Happy Hanukkah and eat some latkes.
Anyway, links from around the world, across the nation and up your street. Have a better one and remain blessed.
Nightmare: Solid Red Alabama Elects Radical Pinko; Jones Wins in a Squeaker...
...Roy Moore Refuses to Concede, Says Race is "Not Over," Floats Possible Recount...
...Trump Congratulates Jones...
...Steve Bannon Blamed/Mocked for Loss by Same GOP, Others Who Torpedoed Moore From the Beginning...
...McConnell: New Alabama Senator Won't Be Seated Until Next Year...
...Playing to Lose: The GOP-Establishment Got What It Wanted
Islamist Terrorist Detonates Bomb in NYC, But CNN Focuses on How Many Diet Coke's PDT Drinks
Double Standards and Distortions: Media Rips Trump as Hater, Yet Ignores Islamist- and Black-Nationalist Hatred
Levin Rips Gillibrand as a "Fraud" and a "Chameleon": Metaphorical Democrat Guns Now Focused on Trump
MN Governor to Announce Franken Replacement Today Despite Franken Not Having Officially Quit Yet
Rush: Is CNN Protecting "Pencil-Neck" Schiff?
PA Dept. of State Threatened with Lawsuit for Stonewalling Noncitizen Election Records
J. Christian Adams: What's Happening at the DoJ
Congress Should Investigate, Not Bail Out, Health Regulators Who Risked Billions
Illegal Alien Released from Prison Convicted of Hammering Five to Death in San Francisco
Groperdammerung Files: Famed Restaurateur Allegedly Has "Rape Room" in NYC Eatery Part Owned by Jay-Z
No, "Global Warming" Isn't Killing Off the Polar Bears
Glick: Europe's War Against the Jewish State
Erdogan's Threat to Jerusalem, and What Israel and the US Must Do in Response
Chanukah, Heroism and President Trump
posted by at 06:47 AM
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� Weekend Gun Thread | Main | The Morning Report 7/2/18 �
Sunday Overnight Open Thread (7/1/18 )
The Quotes of The Day
Quote I
“It’s a weird case, right. He allegedly stole a bridge. I’m fascinated by it.” Judge Philip Simon
Quote II
"God forbid, Ruth Bader Ginsburg dies, or [Anthony] Kennedy retires or [Stephen] Breyer has a stroke or is no longer able to serve. Then we're not talking about Scalia for Scalia, which is what Gorsuch is, we're talking about Scalia for somebody on the Court who shares our values. And then all of a sudden the things I fought for with scars on my back to show for it in this state are in jeopardy." Sen. Claire McCaskill (D-MO)
Scars? More like hemorrhoids.
Quote III
Where is the politician who has not promised to fight to the death for lower taxes- and who has not proceeded to vote for the very spending projects that make tax cuts impossible? Barry Goldwater
The Saturday Sunday Night Joke
A nun walks into Mother Superior’s office and plunks down into a chair. She lets out a sigh heavy with frustration.
“What troubles you, Sister?” asked the Mother Superior. “I thought this was the day you spent with your family.”
“It was,” sighed the Sister. “I went to play golf with my brother. You know I was quite a talented golfer before I devoted my life to Christ.”
“I seem to recall that,” the Mother Superior agreed. “So I take it your day of recreation was not relaxing?”
“Far from it,” snorted the Sister, “in fact, I even took the Lord’s name in vain today!”
“Goodness, Sister!” gasped the Mother Superior, astonished. “You must tell me all about it!”
“Well, we were on the fifth tee…and this hole is a monster, Mother Superior – 540 yard Par 5, with a nasty dogleg left and a hidden green….and I hit the drive of my life. I creamed it. The sweetest swing I’ve ever made. It’s flying straight and true, right along the line I wanted…and it hits a bird in mid-flight !”
“Oh my!” commiserated the Mother. “How unfortunate! But surely that didn’t make you blaspheme, Sister!”
“No, that wasn’t it,” admitted Sister. “While I was still trying to fathom what had happened, this squirrel runs out of the woods, grabs my ball and runs off down the fairway!”
“Oh, that would have made me blaspheme!” sympathized the Mother.
“But I didn’t, Mother!” sobbed the Sister. “And I was so proud of myself! And while I was pondering whether this was a sign from God, this hawk swoops out of the sky and grabs the squirrel and flies off, with my ball still clutched in his paws!”
“So that’s when you cursed,” said the Mother with a knowing smile.
“Nope, that wasn’t it either,” cried the Sister, anguished, “because as the hawk started to fly out of sight, the squirrel started struggling, and the hawk dropped him right there on the green, and the ball popped out of his paws and rolled to about 18 inches from the cup!”
Mother Superior sat back in her chair, folded her arms across her chest, fixed the Sister with a baleful stare and said… “You missed the freakin’ putt, didn’t you?”
On the look out for a bitch. And her dog to.
A social media hunt has been launched to identify a woman who allowed her dog to poop in the middle of the airport and didn't clean it up.
The incident was caught on video by an onlooker at Denver International Airport.
The foul footage shows the owner talking on the phone near a gate - ignoring the sizable pile of poop by her feet.
It is about time that the concept of shame was brought back.
New York's Junior Senator, Chubby McChub-Chub. Is not the brightest bulb in the pack.
Sen. Kirsten Gillibrand, D-N.Y., declared Thursday on national TV that the newest member of the Supreme Court, Justice Neil Gorsuch, did not receive an affirmative vote from “one Democrat” in his confirmation process.
Which is, in effect, a true statement considering Gorsuch received THREE Democrat votes.
Have to love the Left's permanent amnesia. Justice Kennedy's retirement for a Trump selection bad. Ginsburg retiring so Obama can replace her good.
Ruth Bader Ginsburg is one of the more important liberal litigators and jurists of her generation. She has been trailblazer on the issue of women's legal rights and a powerful voice for progressive causes as a justice on the highest US court in the land.
And she must retire. Right now. While we're at it, Stephen Breyer should retire too.
This call has nothing to do with either justice's job performance. Ginsburg's commanding dissent in last year's 5-4 decision to overturn a key provision of the Voting Rights Act is compelling evidence that she remains a vital member of the court.
But no longer is the decision of when to retire about them; rather it's about what comes after they leave the court. If Ginsburg and Breyer wait to retire, it will only serve to maximize the possibility that a Republican president will choose their successor and in the process undo much of what they've worked for their entire careers.
Thankfully Ginsburg ego is pretty damn yuuge.
The ONT Musical Interlude
July 1, 1981, Rushton Moreve bassist with Steppenwolf, was killed in motorcycle accident in Santa Barbara, California, aged 32. He co-wrote their hit 'Magic Carpet Ride' with lead singer John Kay; Steppenwolf also had the 1968 US No.2 single 'Born To Be Wild'. Moreve left the band in late 1968 when he refused to fly back to California at that time, fearing it would sink into the Pacific Ocean after an imminent earthquake. via thisdayinmusic.com
Most early Steppenwolf videos have Nick St. Nicklaus on bass.
July 1, 1945, Born on this day, Deborah Harry, American singer, songwriter, and actress with Blondie who scored five UK No.1 singles including the 1979 UK & US No.1 single 'Heart Of Glass' and the 1978 world-wide No.1 album Parallel Lines. As a solo artists she scored the 1986 UK No. 8 single 'French Kissing In The USA'. A former Playboy Bunny, her acting career spans over thirty film roles and numerous television appearances. via thisdayinmusic.com
Don't forget to water the plants and Border Collies. h/t Hank Curmudgeon
Drunk? You haven't seen drunk until I become the Genius Award Winner.
It is never, ever, never too late to turn your life around. Tonight's Feel Good Story of The Day. h/t Doc Rochester
Tonight's ONT has been brought to you by Truth.
Notice: Posted with permission by AceCorp, LLC. Golf claps are optional. Gripes, bitches and ONT tips to petmorons at gmail dot com. Everything else to Mr. Ace.
Weekly commenter stats for week of 7-1-2018
Top 10 commenters:
1 [576 comments] 'platypus, gg channel' [80.83 posts/day]
2 [420 comments] 'garrett'
3 [407 comments] 'Skip '
4 [402 comments] 'Christopher R Taylor'
5 [400 comments] 'Your Decidedly Devious Uncle Palpatine, SMR and Ancient Slavonaut Newsletters'
6 [386 comments] 'Tom Servo'
7 [386 comments] 'Jak Sucio'
8 [384 comments] 'Jane D'oh'
9 [329 comments] 'Cannibal Bob'
10 [317 comments] 'J.J. Sefton'
Top 10 sockpuppeteers:
1 [71 names] 'Adirondack Patriot' [9.96 unique names/day]
2 [68 names] 'Duncanthrax'
3 [50 names] 'Axeman'
4 [49 names] 'The Political Hat'
5 [46 names] 'Cuthbert the Witless'
6 [46 names] 'T h e W i d e L a t i n a'
7 [39 names] 'Damnedyankee'
8 [39 names] 'Miklos Molnar'
9 [38 names] 'Rick in SK'
10 [37 names] 'Jak Suci
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You are at:Home»Posts Tagged "Mike Kohn"
Browsing: Mike Kohn
Former soldier wins Olympic gold
By on February 27, 2010 Army
Former soldier Steven Holcomb piloted the USA-1 bobsled Saturday to the United States’ first gold medal in four-man bobsled since 1948. Along with teammates Justin Olsen, Steve Mesler and Curt Tomasevicz, Holcomb set the track record during the first heat on Friday and then set it again on the second run to take a commanding lead. Two more strong runs Saturday ensured the “Night Train” sled piloted by Holcomb would give the U.S. its first gold in the four-man in 62 years. The win caps an amazing journey for Holcomb, a former Utah National Guardsman who needed surgery in 2008…
Olympic two-man bobsled
By Alan Lessig on February 23, 2010 Uncategorized
USA-3 driver Sgt. Mike Kohn, a soldier in the Virginia National Guard, and Nick Cunningham run through turn seven during the second of four competition runs Feb. 20 at the Whistler Sliding Center in Whistler, British Columbia. The pair finished 12th overall. (Photo by Sam Riche/ USA TODAY) Sgt. Mike Kohn settles into the bobsleigh in front of brakeman Bill Schuffenhauer during two-man bobsleigh training heats Feb. 18 at the Whistler Sliding Center in Whistler, B.C. (Photo by Christopher Gannon/ USA TODAY) The USA-2 two-man bobsleigh team of driver Sgt. John Napier, a soldier in the Vermont National Guard, and…
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Home / USPTO to Host Public Roundtables on Requests for Continued Examinations /
USPTO to Host Public Roundtables on Requests for Continued Examinations
13-Feb-2013 | Source : AG-IP News | Visits : 7130
WASHINGTON - The US Department of Commerce’s United States Patent and Trademark Office (USPTO), in collaboration with the Patent Public Advisory Committee (PPAC), will host a series of public roundtables to solicit stakeholder input on ways the agency can reduce the number of Request for Continued Examination (RCE) filings.
A press release by the Office stated that the initiative is part of the USPTO’s continuing efforts to reduce patent application pendency. The programs, at which the public is invited to speak, will be held at five venues across the US, beginning Wednesday, February 20, 2013, in Santa Clara, California, and running through March 8, 2013, with stops in Dallas, Texas, New York, New York, Alexandria, Virginia, and Chicago, Illinois.
Reducing the patent application backlog remains a core objective of the USPTO. The agency has decreased the unexamined patent backlog from more than 750,000 to just above 600,000 since 2009, a 20 percent reduction despite an increase in filings each year of about 5 percent. During that time, the USPTO has also reduced the average time it takes to receive a first action on an application from 27 months to slightly more than 20 months. Decreasing the backlog of continued examinations remains a key focus of the USPTO.
“In the pursuit of issuing the highest quality patents, the examination process may take more than one round,” said Acting Under-Secretary of Commerce for Intellectual Property and Acting Director of the USPTO, Teresa Stanek Rea. “One of the purposes of this outreach effort is not to eliminate RCE practice, but to enable applicants to better understand the full range of alternative options we have available during the examination process.”
A variety of initiatives implemented in recent years, such as the Quick Path Information Disclosure Statement (QPIDS) pilot and After Final Consideration Pilot (AFCP), have led to significant improvements in compact prosecution and a substantial reduction in the unexamined patent application backlog.
USPTO is seeking to better understand the root causes for filing RCEs and plans to use the information gathered during the public events to design additional programs and initiatives aimed at reducing filings and the RCE backlog. To that end, the USPTO, in collaboration with PPAC, is providing a variety of forums where stakeholders can openly discuss reasons for filing RCEs and share ideas for reducing RCE filings through the submission of written comments by email or postal mail, through the web-based portal called IdeaScale®, and through five roundtables.
WIPO's Beijing Treaty Enters into Force: Begins Helping Actors and other Performers
BCEC Announces the Final Slate of ICANN Board Director Candidates Selected by the At-Large Community
New Official Charges for IP Services in Saudi Arabia
INTA Launches Unreal Campaign
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Open source traffic analysis
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Congress rejects corruption charge against Michel Temer
Opposition deputies hold a suitcase with fake money before the vote in congress. Source: Adriano Machado/Reuters.
This material belongs to: Al Jazeera.
Congress rejects corruption charges, preventing Temer from Supreme Court trial that could have seen him ousted.
Brazil’s lower house of congress voted on Wednesday to reject a corruption charge against President Michel Temer for allegedly taking bribes, saving him from facing a possible Supreme Court trial that could have ousted him from office.
At least 172 of the 513 members of the lower Chamber of Deputies had voted by late Wednesday against putting Temer on trial for allegedly orchestrating a scheme to line his own pockets with millions of dollars in illicit payments.
Temer won enough ballots to keep the opposition from gaining the two-thirds of the vote – or 342 votes – required to move the corruption case forward to the top court. A final tally was expected later Wednesday night.
The strong show of support for Temer raised the prospects that he can now move ahead with controversial economic reforms in an economy emerging from recession.
Al Jazeera’s Daniel Schweimler, reporting from Brasilia, said Temer was always confident he would win the vote and had pledged over $1bn of government funds for projects to various members of congress to ensure their vote.
“So he is no doubt is breathing a sigh of relief – for now at least,” said Schweimler.
But Temer is widely expected to face more corruption charges in the coming weeks, which would again put his presidency at stake.
‘Tired of so much suspicion’
Opposition lawmakers, carrying briefcases stuffed with fake money, chanted “Out with Temer!” on the house floor at the start of the day-long tumultuous session.
Temer’s main coalition ally, the Brazilian Social Democracy Party (PSDB), which seeks to win the presidential election next year, was split on whether to back Temer, whose economic policies it shares, or distance itself from his corruption-plagued government.
PSDB leader Ricardo Tripoli, calling for the charge to be approved, said Temer must be investigated, “not because we want to oust the president, but because Brazilians are tired of so much suspicion surrounding their politicians”.
To shield Temer only further undermines the credibility of Brazil’s political system, Tripoli said.
Brazil’s top prosecutor Rodrigo Janot in June charged Temer with arranging to eventually receive a total of 38 million reais ($12.16m) in bribes from the world’s largest meatpacker, JBS SA in return for political favours.
Temer and his legal team have denied any wrongdoing.
Brazil’s stocks and currency rose earlier on Wednesday after a cloture vote signalled a victory for Temer and robust support for his reform agenda to cut spending and restore confidence in government accounts.
‘This drama is by no means over’
Armando Castelar, a professor of economics at the Federal University of Rio de Janeiro, told Al Jazeera that – although Temer’s approval ratings are very low – the vote showed Temer’s strength in congress and he will be able to return to his economic agenda – and that Castelar said that Temer’s pledge not to run for re-election in 2019 is a further strength.
“This usually facilitates support in congress because parties don’t see him as a future opponent if things go well. So this may work for the better for the economy – obviously it’s not a desirable situation for a political perspective,” he said.
“But Brazil is in such a difficult position – with the public sector accounts and low growth, that maybe for this moment it’s not bad news,” said Castelar.
Al Jazeera’s Daniel Schweimler said that, while Temer says he wants to get on with running the country, the so-called ‘Car Wash‘ corruption investigation in which he and many others were implicated is still ongoing.
“The opposition are hoping that more revelations will come to light, especially as many of those implicated are plea-bargaining, they’re naming names, and the opposition are convinced that Michel Temer’s name will come to the fore again,” said Schweimler.
“And [Temer] will no doubt be back in congress at some stage defending himself against new charges of corruption – although he has said he’s innocent and he wants to continue governing. So this drama is by no means over.”
Обвинённого во взяточничестве бывшего сенатора Константина Цыбко приговорили к девяти годам колонии Previous Post
Labor tobacco donations referred to ICAC and electoral authorities Next Post
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Aqeel Tapia
Experimental Games
Escape The School
Escape the School was a game I worked on during my internship at a game development studio called Wings' Intellect. The work involved porting an existing Flash based browser game into a standalone game for the iPad using the Unity game engine. The code was completely re-written in C#.
Escape the School - Source Code
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Ishqbaaz
Published: September 17, 20168:32 pm Updated: September 1, 20198:27 am
Skip to Video in 7
Skip to Video
Ishqbaaaz is an Indian drama television series which is broadcast on Star Plus. It premiered on 27 June 2016 and airs everyday at 10:00 PM IST. Nakuul Mehta, Kunal Jaisingh and Leenesh L Mattoo respectively portray Shivaay, Omkara and Rudra, the three heirs of the Oberoi family.
The story is about a rich business family, the Oberoi family. The family consists of two brothers and their wives. The elder brother Tej has a wife janvi and has an illicit affair with his secretary Swetlana. Tej and his alcoholic wife Janvi have three children. Their elder son is Omkara, a sculptor and a self made billionaire. He has a history of drug abuse. He is an understanding person and hates his father. Tej and Janvi’s second child, Rudra, is a flirtatious guy who is a fitness freak and loves partying and women, however, he does not believe in the concept of marriage. He is very friendly in nature. They also have a daughter Priyanka.She is kind, sweet and simple but had glossophobia and social anxiety disorder. Tej’s younger brother is Shakti has a wife, Pinky. They have one son, Shivaay, who is the eldest son and the face of Oberoi industry and is an arrogant business tycoon personality like his uncle. He is arrogant, snobbish and judges people on the basis of their lineage and social status, rather than their personality or work. He does not believe in love but is engaged with a girl named Tia Kapoor. Shivaay has an unkeen sense of loyalty towards his family name. Both, Tej and Pinky, want their respective sons to inherit the business and thus end up fighting each other. Even after everything the three cousins share an unusually strong bond with each other. They both love their grandmother and Priyanka.
Shivaay is always engaged in cat fights with Anika, a middle class girl who does catering business for supporting her & her adopted brother Sahil’s livelihood. On the other hand, Omkara has come across a girl named Ishana. Ishana is a Gujarati girl who is cheating Omkara for money. The youngest Rudra is been liked by a girl named Soumya. Soumya is a Maharashtrian girl brought up in Chandigarh & has a Marathi accent. Sowmya is grand daughter of friend of Rudra’s grandmother. So she comes to live with them in Oberoi mansion for a short period of time. And Anika, who is planning the wedding of Shivaay and Tia, almost stays in Oberoi mansion doing arrangements.
Meanwhile, the illegal affair of Tej and Svetlana is being recorded and Shivaay is been blackmailed for money for the video. He gets ready to pay them. But the video was leaked to media and been telcasted. After a few incidents at home, Pinky helps Janvi to gain love from Tej and to make him stay away from Svetlana. Even the brothers Tej and Shakthi start coming closer again.
In the coming episodes, Ishaana aka Mala aka Bela succeeds for a short while in breaking Omkara and Riddhima relationship, but the plan flops and Riddhima and Omkara ends back up together. Riddhima tells Om to help her by donning a Krishna outfit. On the festival of Janmashtami, Dadi tells Shivaay to drop Annika hope as its not safe for Annika to go so late at night. In the car, Annika and Shivaay shares their normal bicker, but Annika hurts her foot, which causes Shivaay to drop her inside her house. At Annika house, Shivaay pants burst and he has to change. When he reaches back at Oberoi mansion, he sees Om and Rudra dressed in the same outfit as him and they all question eachother, but Shivaay denies to tell them as to why he was dressed in the Krishna outfit. At the same time Annika arrives to drop Shivaay phone and wallet and explains to them what happened. They all have a laugh but Shivaay feels offended and and shouts at Annika to shut up.
The same day, there is another attack on the Oberoi House which is poisonous gas leak. Annika gets caught in it. Shivaay holds her in his arm and takes her from there and throw water on her for her to regain her consciousness. She is saved.
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10/26announcements
Homily for September 14, 2014
Homily for September 7th, 2014
Twenty-third Sunday after Pentecost
The Holy Apostle and Evangelist Matthew
I Corinthians 4:9-16: We hear St Paul speak to the Corinthians as their spiritual father and exhort them to imitate him in their actions.
Matthew 9:9-13: Our Lord calls the tax collector Matthew, to become one of His disciples and tells the Pharisees that He did not come to call the righteous, but sinners to repentance.
Troparion of St. Matthew: O Holy Apostle and Evangelist, intercede with our merciful God to grant our souls forgiveness of sins.
Kontakion of the Presentation of the Theotokos: The all-pure temple of the Saviour, the most precious bridal-chamber and Virgin, the treasure-house of the glory of God, today enters the Temple of the Lord, bringing with her the grace which is in the divine Spirit; whom also the angels of God do celebrate in song; for she is the heavenly tabernacle.
Sunday, November 16 (Twenty-third Sunday after Pentecost; Apostle Matthew)
6:30 p.m. -- Advent Paraklesis
7:30 p.m. -- Parish Council Meeting
6:30 p.m. -- Great Vespers with Litia and Artoklasia
Friday, November 21 (Entrance of the Theotokos into the Temple)
The Presentation of the Holy Virgin into the Temple is found in the apocryphal gospels, which describe the three-year-old Mary being taken by her parents to the Temple, where she remained in a life of holiness and dedication. Though the story be legend, as symbol it yields insight into spiritual truth. The scriptures for vespers, matins, and the divine liturgy all speak to the relationship between man and God within the context of the Temple and emphasize two themes: holiness and the superiority of the living, eternal temple to that built of stone. In Mary we see both. Rather than being sanctified by the Temple, she sanctifies the Temple and all mankind by becoming herself the perfect temple in which dwelt the eternal Son. Truly she was set apart, even as a child, and consecrated to the most glorious work God granted humanity. Truly she is the instrument by which we, too, become living temples in which God lives and which live eternal. Truly we, the holy, catholic church, the living Temple of God, open our doors to her, most blessed of women, the Holy Mother of God.
Sunday, November 23 (Twenty-second Sunday after Pentecost)
Eucharist Bread …was offered by the Fahmys for the Divine Liturgy today.
November 16 Fahmy Algood/Lavric/Turner
November 20 (Wed. p.m.) D. Root (Artoklasia Bread) Great Vespers with Litia & Artoklasia
(Feast of the Presentation of the Theotokos in the Temple)
November 23 Wood Henderson/Baker/Lockhart
November 30 R. Root Karam/Stewart/Meadows
November 16 Walt Wood I Cor. 4:9-16 135
November 23 Sh. Charlotte Algood Eph. 2:14-22 207
November 30 Warren Strain I Cor. 4:9-16 135
Walt and Charlotte Wood and their family; Tom and Jennifer Skirtech and their family; Tom and Kathy Willingham; Athena and Anthony Zouboukos and their family.
Continue to pray for Metropolitan Paul (who is also the brother of our Patriarch) and the Syriac Archbishop John of Aleppo who were abducted while on a humanitarian mission in Syria.
The icons of the Platytera and the Nativity of our Lord have been ordered for the sanctuary.
* As is our parish custom, we will celebrate the Advent Paraklesis service to the Theotokos in place of Daily Vespers on Wednesday evenings, beginning November 19th, at 6:30 p.m.
* We will celebrate the Feast of the Entrance of the Theotokos into the Temple with Great Vespers with Litia and Artoklasia on Thursday evening, November 20th, beginning at 6:30 p.m.
* We will be serving a meal at the Stewpot Ministries on Saturday, November 29th in conjunction with members of Holy Resurrection and Holy Trinity/St. John the Theologian Orthodox Churches.
* The enthronement of His Eminence, Metropolitan JOSEPH is scheduled for the weekend of December 5-7th at the Cathedral in Brooklyn, NY. Fr. John and Kh. Janet will be attending.
* The Feast of St. Nicholas will be celebrated with Orthros followed by Divine Liturgy on Saturday morning, December 6th, beginning at 9:00 a.m.
* Dr. Christopher Veniamin, Professor of Patristics at St. Tikhon Seminary will be speaking at St. Peter's February 1-4, 2015.
Young Adults Study Group: The Young Adults agreed to begin meeting twice a month. One of these meetings will feature a teaching by Fr. John on various aspects of the Orthodox Christian faith. Topics will include education, ethics and parenting children. The next meetings will be Sunday, November 16th and December 7th and 21st.
Lower Mississippi Valley Teen Retreat: The Teen Retreat will be February 13-15, 2015 at Roosevelt State Park. The speaker for the retreat will be Heiromonk Benedict (Josuah Armitage). His topic will be "Dealing with Doubts about God." We are very excited to have Fr. Benedict come to address this important topic with our teens! Be sure to mark your calendars now.
Dr. Christopher Veniamin, Professor of Patristics at St. tikhon Seminary in South Canaan, Pennsylvania, will visit St. Peter's February 1-4, 2015. He will speak at our church on Monday, Tuesday and Wednesday evenings at 7:00 p.m. His topic will be "The Orthodox Understanding of Salvation." We are priviledged to have a man of Dr. Veniamin's stature with us. This promises to be a most edifying and instructive time for our church. Please put these dates on your calendar and plan to be here.
Fasting Discipline for November
The traditional fasting (no meat, dairy, eggs, fish, wine or oil) is observed on all Wednesdays and Fridays of the month. Beginning November 15th, the first day of the Nativity Fast, the traditional fasting is observed each day of the week. Note, however, through December 19th there is a katlysis on Tuesdays and Thursdays when wine and oil are permitted, and on Saturdays and Sundays when fish, wine and oil are permitted.
Major Commemorations for November
November 16 Apostle and Evangelist Matthew
November 21 Entrance of the Theotokos into the Temple
November 23 St. Amphilochios of Iconium
November 25 St. Catherine the Great-martyr
November 30 Apostle Andrew, the First-called
Happy Birthdays in November:
November 5 -- Alexia Parker (#17!)
November 7 -- Jude Brock (#1!)
November 11 -- Adrian Lavric (#1!)
November 13 -- Sophia Skirtech (#6!)
-- Summer Goss
November 17 -- Karen Cooper
November 21 -- Ken Jones
November 24 -- Mildred Morris
November 29 -- Mike Pigott
Happy Anniversaries in November:
November 26 -- Glenn and Mildred Morris (#48!)
November 28 -- Dn. Terry and Sh. Charlotte Algood (#43!)
Thermostats in the Fellowship Hall: There are two thermostats in the Fellowship Hall—one in the main room to control the air in the main room, and a second one in the Nursery room that controls the air in all four of the Sunday School rooms. Please be sure that both thermostats are set to 80 degrees when you leave the building
Suggestions on use of the Cry Room:
-- Please remember you're in liturgy when you're in the cry room.
-- Its main purpose should be a place for parents to take their children if they're being disruptive during liturgy, staying for 5-10 minutes (or until the child is calmed down) and then returning to liturgy.
-- It should not be used as a main sitting area during the liturgy.
-- Children should not be eating snacks or watching electronic devices while in the cry room.
Quotable: "When you learn what the world is, by distinguishing these matters you will also come to know your entanglement as well as your freedom from it. But that I may speak briefly: the world is the carnal way of life and the 'mind of the flesh.' Hence, a man's elevation above the world can also be recognized from these two things: from the good transformation of his way of life and from a discernment of his thoughts."
St. Isaac the Syrian
Worship: Sunday, November 16, 2014 (Twenty-fourth Sunday after Pentecost; Sunday
after the Presentation of the Theotokos)
Scripture: Ephesians 2:14 to end; Luke 12:16-21
Prosphora: Wood
Coffee Hour: Henderson/Baker/Lockhart
posted by Daniel Root at 9:53 AM Parish Life
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Climate alleged to be biggest threat
LONDON, Jan 15 (Thomson Reuters Foundation) - Climate-change-related threats such as extreme weather, large-scale biodiversity losses and a failure of political leaders to slow planetary heating are now the top long-term risks facing the globe, business and other leaders said on Wednesday.
An annual risk survey published ahead of the World Economic Forum next week put climate threats ahead of risks ranging from cyberattacks and pandemics to geopolitical conflict and weapons of mass destruction for the first time.
"That's new. Last year we didn't have it," said Mirek Dusek, deputy head of the Centre for Geopolitical and Regional Affairs and an executive committee member of the World Economic Forum, of the rise of environmental issues up the list.
Really? The history of humans on Earth has been progressively more violent and destructive wars. Another world war would surely be a lot bigger threat that the ocean level rising a few inches.
There are also possibilities of plagues, famines, meteor strikes, etc.
Islam is on a collision course with Christianity. Islam cannot coexist with other religions. Every country that allows Islam to flourish is eventually taken over by Mohammedans. Unless some corrective action is taken, we are headed for war. Or more wars, I should say, as we have already fought Islamic wars in Bosnia, Kosovo, Kuwait, Afghanistan, Iraq, Libya, and probably some other countries that I have forgotten.
It also seems likely that Third World population growth will lead to more wars. Already it is leading to most of the above-mentioned climate change threat.
Update: A computer complexity professor heading to Davos writes:
Much as Greta has been doing for the other essential truth here, that civilization’s current m.o. is producing an unfolding catastrophe on a scale where, to find its approximate parallel, you’d have to go back past WWII, past the Black Death, past the extinctions of the Ice Ages, all the way to something like the Chicxulub asteroid? ...
I’m mostly worried about so-called “tail risk,” of runaway warming basically ending both the natural world and agriculture as human beings have known them. And I’m worried mostly because of an additional thing I believe, which is that one generation’s “tail risks” become the next generation’s “tailbone risks” become the rump risks of the generation after that, which indeed is how we got to where we are now. And the world has shown no ability to coordinate on anything as big as decarbonization, to get out of defect-equilibria, and it’s not obvious to me that that will change, even if I imagine the plausibly desperate situations 50 or 100 years from now.
This is way beyond anything predicted by the IPCC.
Labels: climate, war
Senate to exonerate Trump
The coup attempt continues
Warren wants to criminalize misinformation
No Epidemic of Antisemitism
Principle of no crime without law
100 seconds to midnight
The weak and dishonest case against Trump
Jews control news media and entertainment
Languages spoken in America
Leftist gender nonsense invades hockey
Politically motivated falsification of history
What made America great?
Pelosi may have sabotaged Sanders and Warren
Liberals used to be anti-immigration
Irrational fear of being identified
Hungary abolishes gender studies
Christian channel gets de-monetized
NY Times libels those who want to limit immigration
The Crisis of the 2020s
Brooks is only good at name-calling
GOP leader silenced for saying who is behind impea...
Debating racism with a woke author
The Death of the West
Demise of White Christian America
Not OK to be White in Wisconsin
Fat feminists hate exercise bikes
Alternate theory of Jewish intelligence
Evidence of sex differences
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BOLLI Matters
On the Lighter Side with Larry, THE WRITERS GUILD
ON THE LIGHTER SIDE? WITH LARRY: BE CAREFUL…
January 26, 2020 swurster 3 Comments
By Larry Schwirian
Prompt: What kind of problems would Superman have in old age?
When I was a young kid growing-up, I had fantasies of being a super hero; Superman seemed to me to have all the physical qualities that I aspired to have as an adult. But I never thought about some of the problems he might encounter as time passed and he aged, especially what his life might be like as an octogenarian or nonagenarian. In particular, I never thought about what would happen if his secret identity was ever discovered.
One of the things that Clark Kent had to do in order to keep his secret identity was to allow himself to age like a normal human. This was not really much of a problem when he was in his 30’s, 40’s, and 50’s, but by the time he reached retirement age, his physical appearance was anything but super. He was practically bald, had sagging chins, was developing age spots, and was more than a little overweight. He was so overweight, in fact, that he had to use his X-ray vision to be able to see his feet. Also, since he was never able to go to an earthly dentist, many of his teeth were rotted or missing.
Metropolis had grown substantially over the years since it was considered one of the safest cities in the world, and Clark Kent was getting tired of being constantly called upon by the mayor to solve the city’s problems. He badly needed some rest, so he grabbed Lois, left his home town, and flew south to Miami Beach.
He and Lois Lane had finally become a couple some thirty years earlier when Lois figured out his real identity when she caught him taking off his Clark Kent clothes in a phone booth. She just couldn’t believe that the eternally wimpy Clark could actually be her dream lover. As it turned out he was never able to fulfill her dream anyway since his public moniker “man of steel” turned out to be a double entendre; Lois took one look and nixed the whole idea. They never bothered to marry either, since Clark didn’t have a birth certificate, at least from any Earthly place, and being such a Boy Scout, he refused to forge a fake certificate.
By the time he became an octogenarian, all he wanted to do was sit back and enjoy his retirement. However, Russian agents had hacked into his Facebook and Twitter accounts some years earlier and outed him to the American public. Now everywhere he went, no matter his aged appearance, he was asked to perform tricks like jumping over tall buildings or stopping speeding trains. Occasionally, some jerk even took a pot shot at him to see if he would survive. What a pain in the butt these guys were since he would then have to call the authorities. He really missed his anonymity.
One of the most excruciatingly difficult things about being an aging super-person was the public embarrassment of having to apologize for things he could no longer control. Especially when it came to bodily functions. Every time he farted in a theatre, the place would quickly empty of patrons; the smell was just disgustingly unworldly. When he belched, it could be heard everywhere within a half mile radius and would set off car alarms. When he sneezed, anyone within one-hundred yards would typically be blown away, and trees and bushes would be defoliated. No one except Lois wanted to be around him anymore. He frequently wanted to die but didn’t know how or even if it was even possible for him to do so on planet Earth.
Finally, one fine morning he donned his old ill-fitting Superman outfit, threw on his cape, kissed Lois goodbye and set of for the ninety-three million mile journey to the center of the sun where he hoped to end it all.
BOLLI Matters feature writer and co-chair of the Writers Guild, Larry Schwirian
Architect Larry and his fellow architect wife Caroline live in an historic preservation home in Newton and, together, have led BOLLI courses on architecture. Larry has been an active participant in and leader of the Writers Guild special interest group as well as serving on the BOLLI Journal staff.
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3 thoughts on “ON THE LIGHTER SIDE? WITH LARRY: BE CAREFUL…”
Ruth Bramson says:
We all understand Superman’s situation. Wish we could just take off to another planet.
Barring that, we can just enjoy every day, knowing we feel better than our age. Cute article!!!
Lawrence Schwirian says:
Thanks, I’m glad you appreciated it.
Lois Biener says:
Great fable!
BOLLI Matters: Contents
Click on an item’s title to read the article. Click on a category (above the top photo line) to bring up all the items of that type in a continuous roll.
BOLLI HOMEPAGE: Takes you to all information about BOLLI.
BLOG HOME: Takes you back to where you started on the blog.
MASTHEAD: Who’s Who on the blog. (Which could include YOU)
BOLLI BLOGGERS: Members who have their own websites for blogging about their areas of special interest.
OUR BLOG FEATURES
After Dark Donna Johns offers up news of Boston area events of potential interest to BOLLI members.
The Book Nook Abby Pinard reviews a wide range of titles–one at a time or, at other points, in “clusters.”
Chef’s Corner John Rudy shares his favorite recipes.
Creative Nonfiction Any and all BOLLI members are invited to share nonfiction writing–travel, biographic sketches, reviews, sports, etc.
Stories from Steve Steve Goldfinger shares thoughts, memories, and more.
Lines from Lydia Our resident “Renaissance Woman” and BOLLI Matters co-editor Lydia Bogar writes about… whatever has captured her attention this time!
Meet Our Members Co-editor Sue Wurster introduces members with whom you might share interests.
Memoir Writing Any and all BOLLI members are welcome to share their work.
Pop Culture with Dennis Greene Dennis focuses on movies, television, books, and pastimes, past and present.
Senior Moments Various members focus on the unique aspects of this stage of our lives.
Tech Talk John Rudy moves from the kitchen to the desk and laptop to provide tips on technology.
Volunteer Matters BOLLI members share their experiences in a variety of volunteer settings.
What’s on Your Mind? A “catch-all” feature for other items of interest–by anyone!
Other features include catching up with the activities of our Special Interest Groups
The Aging with Resilience and Enthusiasm
Group explores issues we all face–maintaining friendships, considering living arrangements, facing ageism, and re-envisioning our lives. Leave feeling refreshed and cheerful!
The Banner, BOLLI’s longtime newsletter, has gone online. Those interested in writing about BOLLI’s inner workings–courses and SGLs; administration and staff; committees; Brandeis activities, opportunities, personnel; and more.
The Book Group meets once a month to discuss a work of contemporary literary fiction. We love to read and talk about books!
CAST, BOLLI’s Creative Acting, Storytelling, and Theatre troupe, engages in improvisation, theatre, and storytelling games and exercises as well as working to develop individual, paired, and/or small group script-based performances.
Current Events Discussion Group features respectful and lively discussions that cover international, national, and local events of interest.
The Make a Difference Group responds to political emergencies and outrages, turning our personal political/policy passions into action plans
New Yorker Fiction Salon meets weekly throughout the year to discuss short stories featured in this popular magazine’s offerings
The BOLLI Photo Group members have a passion for photography and a desire to become better practitioners of this art.
The Play Reading Group meets to read aloud scripts of interest–from “old nuggets” to newer gems.
The Poetry Circle discusses the work of modern and contemporary poets. (Experience with poetry is variable among those attending.)
The Poetry Writing Workshop meets monthly to give writers of poetry, at all levels, an opportunity to share their work with others and receive constructive feedback.
Social Change Working Group brings speakers to BOLLI who cover the various social ills of our time and identify possibilities for meaningful and constructive response.
Waltham Matters provides a forum to discuss and explore the Waltham of both the past and present.
Writers Guild is a comfortable, supportive place for sharing original written work and getting helpful responses from peers. A writing prompt is provided in each week’s Bulletin.
and, of course–
BOLLI MATTERS Ideas? Suggestions? A feature you’d like to see? Want to submit a member profile–of yourself or another member? Want to showcase your photography, art work, or writing? Join the blog’s host of writers.
TO LEARN MORE about our Special Interest Groups, visit brandeis.edu/bolli and look under “Courses and Programs” for details about how to get involved.
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WHAT’S COMING UP?
To request information about BOLLI, please click this link:
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GLORIA’S STUDIO OPENING May 26, 2021
ON THE LIGHTER SIDE WITH LARRY: CLOUD NINE May 26, 2021
PANDEMIC DAYS with Sue Wurster: COVID-19 YIN AND YANG March 11, 2021
PANDEMIC DAYS with Peter Bradley: Walk–Late Winter March 11, 2021
MEMOIR from Susan Bradford January 19, 2021
PANDEMIC DAYS: Let’s Share… January 19, 2021
GLORIA’S STUDIO OPENING
ON THE LIGHTER SIDE WITH LARRY: CLOUD NINE
PANDEMIC DAYS with Sue Wurster: COVID-19 YIN AND YANG
PANDEMIC DAYS with Peter Bradley: Walk–Late Winter
MEMOIR from Susan Bradford
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Joe tap dancing in "Born to Sparkle" in Palm Springs, CA 2022.
Teaching, Consulting, and Directing
Hi...this is Joe G...."How can I help you?"
Are you winning enough 1st places in competitions?
As a teacher/parent, do you have questions that need answers?
Teachers - Do your male students need a mentor?
Dancers - Do you have questions?
Remember - "Steps are learned...style is taught...I can do both" - Joe G.
"I can be your personal coach/consultant ...I have over 30 years experience as a dancer, performer, choreographer, director, judge, motivational speaker and in musical comedy theatre. I am recently "off the road" as director of the #1 dance convention and competition in the United States!"
Master Classes - TAP, BALLET, YOGA, and MUSICAL THEATRE. Available for travel.
Let Jag Co. Productions take you to the next level!
Tap Dance Classes Keep Malibuites on Their Toes!
by Ward Lauren
"Flap, flap, flap, ballchange, shufle, hop step, flap, heel-drop!" Not just the unique percussive sounds but the words as well echo rhythmically from the fitness center at Zuma Beach Plaza three times a week as Malibu's adult tap dance hoofs it up with veteran dancer and choreographer Joe Giamalva.
The class is drawing a growing number of women and yes, a man or two, to tis Monday and Wednesday sessions. With seemingly unbridled enthusiasm they enjoy a three-phase participation in the veneralbe Amercian dance form: learning the basic steps, performing them in a group dance routine, and, far from last, getting valuable pound-dropping cardiovascular exercise while having a whale of a good time.
Students have come to the Malibu class for a variety of reasons, none apparently having anything to do with serious hopes of future fame on the Broadway stage.
"The greatest joy of my life is tapping," said Malibu resident Joan Steiger, who first set foot to the dance floor at age seven. "You can never tap and not smile."
Although she has tap danced occasionally in television commercials, Steiger said she didn't have much time to practice her art during the years she and her late actor husband Rod Steiger traveled extensively. He urged her to take it up again when they settled in Malibu estates shortly before his death.
Hair stylist Bernie Safire, on the other hand, put on his first pair of tap shoes only eight months ago. An ex-gymnast, he occasionally works out on the trampoline and high bar to keep in shape, but now gets most of his physical conditioning in tap class.
"It's just about the most fun of anything I've ever done," Safire said enthusiastically. "People in the gym don't know what this is all about; this is great!"
Giamalva's teaching method is strictly hands-on, or feet-on in this case, with liberal applications of fun and encouragement. He stands at the front of the class and demonstrates every step, then joins in practicing them with his students, slowly at first and gradually building up tempo to the accompaniment of familiar, lilting melodies played from the CD sound system.
The action starts with basic warm-ups: a simple shuffle on one foot for awhile, then the other, then circling the room behind the teacher, doing basic "flap." One by one, other basic steps are shown and practiced as the class circles the room in rhythm to the CD. Then, getting down to business, the students stand in horizontal rows behind Giamalva as he puts the warm-up steps together in combinations. As the hour-long class progresses, more steps are added unti, almost surprisingly, they become an entire dance routine.
Teaching, as well as performing, is nothing new to Joe Giamalva. For several years before moving to Malibu, he held classes in Agoura, and he still conducts a class in Woodland Hills on Tuesdays. He also teaches jazz, ballet and musical theater, and serves on judges' panels at many major dance competitions.
Giamalva has a long and diverse career in show business as a producer, director, choreographer and performer. He has toured the world in shows with such stars as Raquel Welch, Tony Martin, Cyd Charisse, Donnie and Marie Osmond, and Cher. He choreographed many theater productions and the original L.A. Laker Girls learned their cheerleading/dance routines from Giamalva. Through his own production company, Giamalva continues to mount shows and special programs fro film, television and industrial and commercial corporations.
email: Jagco1@aol.com
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Inductive Discovery of Criminal Group Structure Using Spectral Embedding
3102_inductive_discovery_criminal_group.pdf
Francesco Calderoni; David Skillicorn; Quan Zheng
Information & Security: An International Journal, Volume 31, p.49-66 (2014)
Italian Mafia, network evolution, Oranised crime, Simmelian backbone, Social network analysis
Social network analysis has often been applied to the content of communications within criminal groups to understand their internal structure and dynamics. While access to the content of communications may be restricted by constitutional and procedural constraints, this article applies advanced network analysis techniques based on spectral embedding to telephone communications data. Spectral embedding facilitates deeper analysis by embedding the graph representing a social network in a geometric space such that Euclidean distance reflects pairwise node dissimilarity. This enables drawing a network in ways that accurately reflect the structure of the underlying group, and computing properties directly from the embedding. We illustrate spectral approaches for two Ndrangheta drug-smuggling networks, and extend them to a) examine triad structure (through the identification of the Simmelian backbone), which elicits key members, and b) to display temporal properties, which illustrates changing group structure. The results show that the two groups, although having the same purpose and coming from the same criminal milieu, have substantially different internal structure which was not detectable using conventional social-network approaches. The techniques presented in this study may support law enforcement in the early stages of an investigation.
Duijn, Paul A. C., Victor Kashirin, and Peter M. A. Sloot. "The Relative Ineffectiveness of Criminal Network Disruption." Scientific Reports 4 (2014).
Duijn, Paul A. C., and Peter P. H. M. Klerks. "Social Network Analysis Applied to Criminal Networks: Recent Developments in Dutch Law Enforcement." In Networks and Network Analysis for Defence and Security, 121-159. Cham: Springer International Publishing, 2014.
Lupsha, Peter. "Steps Toward a Strategic Analysis of Organized Crime." The Police Chief (1980): 36-38.
Lupsha, Peter. "Networks vs. Networking: Analysis of an Organized Crime Group." In Career Criminals. Beverly Hills, CA: Sage, 1983.
Davis, Roger. "Social Network Analysis: An Aid in Conspiracy Investigations." FBI Law Enforcement Bulletin (1981): 50, 12, 11-19.
Ianni, Francis, and Elizabeth Reuss-Ianni. "Network Analysis." In Criminal Intelligence Analysis, 67-84. Loomis, CA: Palmer Enterprises, 1990.
Sparrow, Malcolm K.. "Network vulnerabilities and strategic intelligence in law enforcement." International Journal of Intelligence and CounterIntelligence 5, no. 3 (1991): 255-274.
Sparrow, Malcolm K.. "The application of network analysis to criminal intelligence: An assessment of the prospects." Social Networks 13, no. 3 (1991): 251-274.
Jackson, Janet, and Janet Herbrink. Profiling Organised Crime: The Current State of the Art In Report NSCR. Leiden: Netherlands Institute for the Study of Criminality and Law Enforcement (NISCALE), 1996.
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Logan, Dave, John King, and Halee Fischer-Wright. Tribal Leadership: Leveraging Natural Groups to Build a Thriving Organization. Reprint ed. New York: HarperBusiness, 2011.
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Morselli, Carlo, Cynthia Giguère, and Katia Petit. "The efficiency/security trade-off in criminal networks." Social Networks 29, no. 1 (2007): 143-153.
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Skillicorn, David, Quan Zheng, and Carlo Morselli. "Modelling Dynamic Social Networks Using Spectral Embedding." Social Network Analysis and Mining 4 (2014): 182.
Paoli, Letizia. "An Underestimated Criminal Phenomenon: The Calabrian ’Ndrangheta." European Journal of Crime, Criminal Law and Criminal Justice 2, no. 3 (1994): 212-38.
Paoli, Letizia. Mafia Brotherhoods: Organized Crime, Italian Style. Oxford: Oxford University Press, 2003.
Calderoni, Francesco. "Identifying Mafia Bosses from Meeting Attendance." In Networks and Network Analysis for Defence and Security, 27-48. Cham: Springer International Publishing Switzerland, 2014.
Calderoni, Francesco. "The structure of drug trafficking mafias: the ‘Ndrangheta and cocaine." Crime, Law and Social Change 58, no. 3 (2012): 321-349.
Calderoni, Francesco. "Strategic Positioning in Mafia Networks." In Crime and Networks, 163-181. New York: Routledge, 2014.
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Tagarev, Todor. "Intelligence, Crime and Cybersecurity." Information & Security: An International Journal 31 (2014): 05-06.
Bichler, Gisela, Aili Malm, and Tristen Cooper. "Drug supply networks: a systematic review of the organizational structure of illicit drug trade." Crime ScienceAn Interdisciplinary Journal 6, no. 2 (2017).
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Bright, David, Johan Koskinen, and Aili Malm. "Illicit Network Dynamics: The Formation and Evolution of a Drug Trafficking Network." Journal of Quantitative Criminology (2018): 1-22.
Malm, Aili, Martin Bouchard, , Marieke Vlaemynck, and Marije Wouters. "More structural holes, more risk? Network structure and risk perception among marijuana growers." Social Networks Volume 51 (2017): 127-134.
Bahulkar, Ashwin, Boleslaw K. Szymanski, Orkun N. Baycik, and Thomas C. Sharkey. "Community detection with edge augmentation in criminal networks." In IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining (ASONAM). Barcelona, Spain , 2018.
Zheng, Quan, and David Skillicorn. Social Networks with Rich Edge Semantics (Open Access). Boca Raton: CRC Press, 2017.
Bahulkar, Ashwin, Orkun N. Baycik, Thomas Sharkey, Yeming Shen, Boleslaw Szymanski, and William Wallace. "Integrative Analytics for Detecting and Disrupting Transnational Interdependent Criminal Smuggling, Money, and Money-Laundering Networks." In IEEE International Symposium on Technologies for Homeland Security (HST). Woburn, MA, USA , 2018.
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Giommoni, Luca, R.V. Gundur, and Erik Cheekes. International Drug Trafficking: Past, Present, and Prospective Trends., 2020.
Campedelli, Gian Maria. On Meta-Networks, Deep Learning, Time and Jihadism. Vol. Doctor of Philosophy in Criminology. Università Cattolica del Sacro Cuore di Milano, 2019.
Bahulkar, Ashwin. Evolution Dynamics of Attribute-Rich Social Networks In Department of Computer Science Rensselaer. Vol. Doctor of philosophy. New York: Polytechnic Institute Troy, 2019.
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APA style: Calderoni, F., Skillicorn D., & Zheng Q. (2014). Inductive Discovery of Criminal Group Structure Using Spectral Embedding. Information & Security: An International Journal. 31, 49-66.
Chicago style: Calderoni, Francesco, David Skillicorn, and Quan Zheng. "Inductive Discovery of Criminal Group Structure Using Spectral Embedding." Information & Security: An International Journal 31 (2014): 49-66.
IEEE style: Calderoni, F., D. Skillicorn, and Q. Zheng, "Inductive Discovery of Criminal Group Structure Using Spectral Embedding", Information & Security: An International Journal, vol. 31, pp. 49-66, November 2014.
DOI http://dx.doi.org/10.11610/isij.3102
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Towards Effective Democratic Oversight of Intelligence Services: Lessons Learned from Comparing National Practices
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The Mugger (87th Precinct Series, Book 2)
By Ed McBain
This mugger is exact.
He preys on ladies, ready within the darkness…then comes from in the back of, assaults them, and snatches their handbags. He tells them to not scream and as they are at the floor, reeling with discomfort and worry, he bows and nonchalantly says, “Clifford thank you you, madam.” but if he places one sufferer within the health center and the subsequent within the morgue, the detectives of the 87th Precinct are usually not amused and should cease at not anything to deliver him to justice.
Dashing younger patrolman Bert Kling is usually there to assist a chum. And whilst a friend's sister-in-law is the mugger's homicide sufferer, Bert's own purposes to discover the maniacal killer quickly develop into a burning obsession…and it may possibly simply get him killed.
The moment publication within the 87th Precinct sequence, The Mugger is an Ed McBain vintage, a nuanced portrayal of justice and vengeance hailed by way of the Daily Mirror as “a masterpiece of crime writing…and there is not anyone who does it better.”
Preview of The Mugger (87th Precinct Series, Book 2) PDF
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Additional resources for The Mugger (87th Precinct Series, Book 2)
I’m sorry. thank you. I couldn’t. ” “Well…uh…” particularly all at once, Kling felt like a idiot. “I…uh… wager I’ll be going, then. thank you for the cognac. It was once really nice. ” “Yes,” she acknowledged, and he remembered her discussing those that have been there and but no longer there, and he knew precisely what she intended simply because she was once now not there in any respect. She used to be someplace far-off, and he wanted he knew the place. With unexpected, determined longing, he wanted he knew the place she was once simply because, interestingly, he desired to be there along with her. “Good-bye,” he stated. She smiled in solution and closed the door in the back of him. The dime within the slot introduced him Peter Bell. Bell’s voice was once sleepy. “I didn’t wake you, did I? ” Kling requested. “Yes, you did,” Bell acknowledged, “but that’s very well. what's it, Bert? ” “Well, is Molly there? ” “Molly? No. She went right down to choose up a number of issues. what's it? ” “I’ve been…Well, she requested me to envision round a bit. ” “Oh? Did she? ” “Yeah. I went to membership pace this afternoon, and that i additionally talked with a lady named Claire Townsend. great woman. ” “What did you discover out, Bert? ” “That Jeannie was once seeing a few man frequently. ” “Who? ” “Well, that’s simply it. omit Townsend didn’t understand. She ever point out anybody’s identify to you or Molly? ” “No, now not that i will have in mind. ” “That’s too undesirable. may possibly provide me whatever to move on, you recognize, if we had even a primary identify. anything to paintings with. ” “No,” Bell acknowledged, “I’m sorry, but…” He stopped lifeless. there has been a painful silence at the line, after which he acknowledged, “Oh my God! ” “What’s the problem? ” “She did, Bert. She did point out somebody. Oh my God! ” “Who? while used to be this? ” “We have been conversing as soon as. She used to be in an excellent temper, and she or he advised me…Bert, she instructed me the identify of the guy she was once seeing. ” “What used to be the identify? ” “Clifford! My God, Bert! His identify is Clifford! ” It was once Roger Havilland who introduced within the first genuine suspect within the alleged mugger homicide. The suspect used to be a child named Sixto Fangez, a Puerto Rican boy who were within the urban for a bit greater than years. Sixto used to be two decades previous and had, until eventually lately, been a member of a road gang often called “The Tornadoes. ” He was once not lively, having retired in want of marriage to a woman named Angelita. Angelita used to be pregnant. Sixto had allegedly beat up a hooker and stolen $32 from her handbag. the lady used to be one of many better-known prostitutes within the precinct territory and had, in truth, rolled within the hay on a very good many events with individuals of the legion in blue. a few of these policemen had paid her for the privilege of her corporation. In usual situations, however the lady had made a good id of Sixto Fangez, Havilland could have been keen to put out of your mind the entire topic in attention of a bit criminal smooth. attack fees were recognized to slide the minds of many policemen whilst the fitting observe, including the correct quantity of foreign money, was once exchanged. It occurred, even if, that the newspapers have been giving a tremendous play to the funeral of Jeannie Paige—a funeral which were not on time by way of the vast post-mortem exam played at the body—on the morning that Sixto was once introduced upstairs to the squadroom.
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Tag Archives: betting
Less = Extra With Betting
Mattress Mack will set a sports activities betting file if the Houston Astros do win the World Collection. If you can’t sleep on the wee hours at night time taking part in video games will show you how to out ease your thoughts. That way I get to catch up on all of the X-box games I missed out on growing up with Mario and Zelda, but I additionally get the unique Sony games that I really like, with the added bonus of promoting them on when I’m finished. Though executives have made a couple of peeps concerning the nebulous “metaverse,” the simple answer is that Microsoft wants more and more exclusive content for its trio of platforms: Xbox consoles, PCs, and the Xbox Recreation Pass, both in obtain and streaming varieties. In the qualifying tournament they have proved themselves as an unbeatable staff successful all the 10 matches. 9. Mexico will wrap up qualifying on Oct. 10 at residence with El Salvador and at Trinidad and Tobago on Oct. 14. Ross Everett is a contract sports writer.
Whereas the sport will launch as a “console exclusive” on PS5, it’ll even be available on Pc, and will probably grace the Xbox Collection X/S within the not-too-distant future. Firaxis itself is presently at work on Marvel’s Midnight Suns, which after a delay is now resulting from launch later this yr. All with out the trouble of extra legal work. Foremost Card (6 p.m. Isaac Hayden is suspended for yellow card accumulation, that means Sean Longstaff may very well be introduced to the side. But now that energy from recency belongs to Sean McDermott and Allen. “Used to be Pat Day, now I feel Calvin owns Churchill Downs. But even on this listing, we’re seeing Microsoft’s strategy encroaching on Sony’s territory: Ghostwire developer Tango Gameworks is a subsidiary of ZeniMax, making it now Microsoft property. Nonetheless, if you are intent on making a decide, taking the below could prove one of the best strategy for a match between two teams which are far from convincing. Traders and fund managers are taking lengthy positions on oil market as they are estimating the OPEC and non-OPEC to scale back the output of Crude oil to increase the costs additional. Laptop) PVP combating recreation on the market.
Imagine being ready to talk in the voice of the character you are playing as in a multiplayer game! VitaminWater, made by famous beverage producer, is at the moment being sued within the United States since every bottle accommodates 8 ounces of water 33 grams of sugar is amazing. But let’s assume that they get via the assorted regulatory hurdles, and Redmond adds certainly one of the largest publishers on the planet to its rising assortment of subsidiaries. Thankfully she likes to get me out of the way in which. Is anyone else getting Notting Hill vibes from that “I’m only a storyteller out right here making an attempt to inform my story” line? Hey everyone – right here is why our Voice NFTs are totally different from simply proudly owning jpegs. Why Microsoft desires Activision Blizzard isn’t notably difficult. Whereas Sony is playing to its strengths, it isn’t resting on them. These kind of hats, whereas they don’t seem to be made for formal events, have develop into trendy in recent years, and are no longer worn primarily by truckers, teenagers or people at sporting occasions. Whereas وان ایکس بت of them are instructional, there are numerous that are mere entertainment. There’s a very extensive number of issues that you could be place your wagers on nonetheless it is always best to merely restrict your self to the movements and can make higher spread bets.
Bets will be excessive on this phase, with 1000’s of bettors finding classes particular to their tastes. Therefore, Sportytrader focuses on such bets. It’s gonna try, anyway, with a deal worth greater than the GDP of a lot of the international locations on the planet, and a host of problems from worker abuse to only straight-up publishing duds, Microsoft may have just purchased the world’s biggest and most costly can of worms. The most important little bit of squad news for Newcastle revolves around midfielder Jonjo Shelvey, who has struggled with a lack of health and was the victim of some load management by manager Eddie Howe. Called Bit Reactor, the studio will deal with the same form of “turn-based mostly tactics” video games its founders are identified for, with a deal with “high-end manufacturing values, riveting storytelling, and progressive design”. Bit Reactor’s announcement supplies focus closely on the team’s experience on XCOM, however members of the studio have also labored on the likes of Civilization and Elder Scrolls On-line. Foertsch himself labored at Firaxis for over two decades, and served as artwork director from 2005 to 2019 on every thing from XCOM and XCOM 2 to numerous games within the Civilization sequence.
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HOURS CONTACT US
Current Picks - Staff Recommendations
Category Archives: Lucille
Monkeewrench by P. J. Tracy (2003)
May 2, 2013 Lucillefiction, mysteryCurrent Picks
This thriller mystery jumps right through cyberspace. A killer begins murdering victims on a computer game. By duplicating each murder exactly, the police department of Minneapolis must try to outwit and out think a psychopathic genius. The story is easy to follow and sure fun to read. Get started with Monkeewrench then read the rest of the series by P. J. Tracy.
Paris: A Love Story by Kati Marton (2012)
April 4, 2013 Lucillebiography, nonfictionCurrent Picks
Kati Marton is an award-winning author, a successful news correspondent, and a woman with a past worth writing about. In her memoir Paris: A Love Story, Paris symbolizes an environment of love, adventure, and finally of healing.
Married twice to men, prominent on the world stage, Kati writes candidly of her glamorous life, magically without offending anyone. Now a widow, she looks over shoulder to a life, filled with passion, service, and possibly integrity.
The Art Forger by B. A. Shapiro (2012)
March 14, 2013 Lucillefiction, mystery, suspense/thrillerCurrent Picks
A thriller without a trail of blood and gore and an author with expertise in the art world, B.A. Shapiro takes us underground to the history and methods of art forgery. When a struggling artist commits to do a reproduction of a famous painting by Degas, the action begins. The plot twists and turns between the past and the present, but I was never confused; rather, I was fascinated by Shapiro’s knowledge in the art world. The Art Forger races to an ending that left me hoping this author will write another book.
The Last Kind Words by Tom Piccirilli (2012)
February 18, 2013 Lucillefiction, suspense/thrillerCurrent Picks
This is at once a modern family saga of the Brands, who have produced generations of thieves, con men, and crooks, but it also story of two brothers. One brother, wild Collie, is in prison, waiting to die for the brutal, senseless, massacre of eight people; the other brother, Terry, a man with regrets, left the family for five years but has returned because Collie needs him to solve a mystery. Now there is twist. Collie claims one of the victims was killed by serial killer, who is flying under the radar and will continue to kill more women.
And so the reader enters the world of the dark side. Is there honor among thieves? Is loyalty to the family their strange salvation? Will Terry find his own core? Wasn’t the “good thief” the first to enter heaven?
This book is more than crime fiction; it explores the psychological effects of one man against his environment who dares to find peace. The author is the winner of the International Thrillers Writers Award and rightly so. Check out The Last Kind Words today.
A Cold Day in Paradise by Steve Hamilton (1998)
January 14, 2013 Lucillefiction, mysteryCurrent Picks
I love a good mystery series and this book entranced me with the awkward characters who are flawed in loveable ways. Set in the upper peninsula of Michigan, usually in winter, the twisted plot vibrates with suspense. I was so taken with the first book, I immediately checked out Winter of the Wolf Moon (2000). What really impressed me is the subtle changes in relationships from book one to book two. Read A Cold Day in Paradise by Steve Hamilton today.
Creole Belle by James Lee Burke (2012)
October 25, 2012 Lucillefiction, mysteryCurrent Picks
Gritty and graphic, James Lee Burke again deftly perpetuates his Dave Robicheaux series. Creole Belle explores the darkest corners of crime in Louisiana. Burke’s true gift lies in his lyrical style. You can see the Spanish moss and smell the rotting bodies. His main characters are flawed creatures but, oh so interesting. Once I started reading, I savored the excitement and the over the top plot, which is Burke’s signature style.
Heading Out to Wonderful by Robert Goolrick (2012)
September 24, 2012 Lucillefiction, mysteryCurrent Picks
Robert Goolrick, author of A Reliable Wife, just keeps getting better. This Gothic novel, set in a tiny village in Virginia in 1948, reveals the dark obsessive love of the town’s strange newcomer for the wife of the town’s richest and nastiest man. Off stage, but still caught up in this story, is an eleven-year-old boy, who takes a lifetime to understand what happened.
Goolrick captures the hypocrisy of the town’s churchmen and their power over the people. All the characters become entangled in the dilemma. More importantly Goolrick intrigues us with intricate and hypnotic delineation of his characters, making us wonder, “How much control do we really have in our lives?”
Check out Heading Out to Wonderful today.
Monday Mornings by Sanjay Gupta (2012)
August 2, 2012 Lucilleaudio, fiction, medicalCurrent Picks
Sanjay Gupta is a practicing neurosurgeon and his background is steeped in medicine. As a writer, he exposes the personal and professional lives of five surgeons in this fictional account, Monday Mornings.
In the medical world, the acronym M & M stands for morbidity and mortality. Sounds alarming, but it is a learning session that dissects the recent operations of the staff. Just as importantly, this session also investigates any questionable outcomes. No surgeon wants a summons to a Monday morning M & M. Five surgeons live and breathe in this book, fully human to pique and admirably maintain your interest. I listened to the book – and I liked the readers too.
David E. Kelly is developing a television show based on the book. Read more here.
The Mysterium by P.C. Doherty (2012)
July 5, 2012 Lucillefiction, historical fiction, mysteryCurrent Picks
History, mixed with sinister mystery and, well plotted too, is like a jewel in the crown. Hugh Corbett in the King Edward’s I service is forcibly retained to solve a series of brutal murders. The streets of Medieval London reek with bloody minded gangs and high born assassins. You do not have to read the other books in the series to appreciate The Mysterium, but you may want to after reading this.
Read The Mysterium by P.C. Doherty.
Unwanted by Kristina Ohlsson (2012)
June 4, 2012 Lucillefiction, mysteryCurrent Picks
Kristina Ohlsson joins the ranks of Scandinavian authors who delve into the dark, sick side of the human condition. Her main character, Fredrika Bergman, is an enigmatic woman trying to find her niche in the male dominated world of police work.
The story starts with a report of a missing child taken from a train. At first, the case does not send any evil vibrations, but then events escalate. Another child is taken and then another. Fredricka intuits that her team is on the wrong track. As the case expands, Ohlsson reveals the inner turmoil and personal problems of her characters, thus pulling the reader more deeply into the story.
Although this book received starred reviews and the author limits the graphic descriptions to a minimum, the dark side is still out there.
One word of caution: the subject matter traces the path of a psychopath and his quirky, ugly reactions to being an abused child, and not everyone is comfortable with this type of material.
Read Unwanted today and share your thoughts on the book here.
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JANUARY 10, 2023 – Cornell Dubilier’s XMPL Polymer Chip Capacitor series from New Yorker
Electronics has been expanded to accommodate higher voltage and capacitance requirements.
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tomales point trail bike
Interdictions. Saw 85 elk, some as close as 15 feet, 1 coyote, several deer, and a seal. Related Trails: Tomales Point Trail: Tule Elk were reintroduced to Point Reyes National Seashore in 1978. This mellow trail is an out-and-back, so you can turn around at any point. I got home and told my son I'd hiked this nothing-burger trail. The trail descends into the wide, shallow valley where the Lower Pierce Ranch used to be located. Past activities . It’s a simple 4.5-mile hike to a promontory overlooking the Pacific. The trail follows the ridge between the ocean and Tomales Bay for 4.7 miles. Tomales Point Trail is a must do We hiked the Tomales Point Trail - 9.4 miles round trip. The trailhead for this hike is located along the Pierce Point Road. Reyes, Tomales Point, where the Tule Elk Preserve is located. Close. This region is known for hikes and beaches on Point Reyes Peninsula and the shoreline of Tomales Bay. Gwen and I did this hike for the first time this month (first week of April). Travel Destinations. Adventure bikes, also known as gravel bikes are popular because of their outstanding versatility. Tomales Point Trail: Long hike - See 100 traveller reviews, 213 candid photos, and great deals for Point Reyes Station, CA, at Tripadvisor. Tomales Point Trail: Nice hike - See 100 traveller reviews, 213 candid photos, and great deals for Point Reyes Station, CA, at Tripadvisor. Tomales Point trail is one of the most popular and highly rated hikes in all of Point Reyes. best. Follow the trail for roughly three miles. Tomales Point Trail ending abruptly where a large section of the bluff collapsed into the Pacific Ocean in January 2017. A group of postdocs hiked to the tip of Tomales Point, in Point Reyes National Seashore. This open trail through the Tule Elk Reserve offers spectacular views of the Pacific Ocean and is a prime wildlife viewing trail. . This mellow trail is an out-and-back, so you can turn around at any point. Embark on an epic bike ride along public paths or explore roads less travelled. If you have 30 minutes to spare, then I suggest you pull over and check it out. Another reminder that sea cliffs are hazardous. moderate Travel. As a result, a section of the Tomales Point Trail is no more. Tomales Point, looking beautiful as ever. It is a 9.4 miles moderate out & back hike with 1,177 feet of elevation gain. Don’t needle them or step off the trail and peace shall be maintained. Zymergen site visit. Kayaking @ Russian river. 0 9 90. Image Credit: Unsplash. The Tomales Point Trail descends to Windy Gap. level 1. Or with an adventure bike - do both! This trail is very well maintained and you are almost guaranteed to see tule elk along the way. Tomales point trail ... Tomales point is a pedestrian and equestrian trail. Millerton Point Hike at Tomales State Park. The Tomales Point Trail is 4.7 miles one-way along the ridge of the northernmost point of Point Reyes, It used to be a fairly quiet trail (according to a book that I use as a guidebook), but it has evidently become extremely popular in recent times. This is the start of the Tomales Point Trail. The first three miles of this trail are maintained and follows the route of an old ranch road as it travels along the crest of the ridge. The trail is mostly flat with unbeatable views of the Pacific Ocean, Tomales Bay, and very close encounters with Tule Elk. Trail is open and if you go on a weekday you wont see too many people. Collapse of Bluff near Tomales Point. Don't need to do that again". It is also a prime wildlife viewing trail, as it is remote and the tule elk are enclosed in this reserve. Share; Tweet; Pin; 0 shares. In January 2017, part of the bluff at the northern end of Tomales Point collapsed. 1 1. comments. Start at the Tomales Point Trailhead near the Historic Pierce Point Ranch. Restaurants near Tomales Point Trail, Point Reyes Station on Tripadvisor: Find traveller reviews and candid photos of dining near Tomales Point Trail in Point Reyes Station, California. - Check out Tripadvisor members' 1,176 candid photos and videos. I finally did, and when I'd almost fully back-tracked to my car I said "Well, done that. The trail to Windy Gap is relatively level. The parking for the Tomales Point Trail is on the site of the Pierce Ranch house and dairy barn where locally famous butter was produced starting in 1858. Also, at the trailhead, Historic Pierce Point Ranch, which was a thriving butter dairy in the late 1800s, has been maintained as a visitor site. North America Travel. Tomales Point Trail, Point Reyes Station Picture: May Wildflowers along Tomales Point Trail. Although the both ocean and Tomales Bay are visible, the views in this middle part of the hike aren’t that great since the hillop is so wide. The Tomales Point Trail runs along coastal bluffs, up the peninsula's spine, and through the Tule Elk Preserve en route to its climactic finish on the Seashore's wave-battered cusp. Log in or sign up to leave a comment Log In Sign Up. The dairy products were shipped to San Francisco from a dock in Tomales Bay. Trail is open and if you go on a weekday you wont see too many people. hide. share. 4 reviews of Tomales Bay Trail "For years now I've driven by the Tomales Bay Trailhead and been consistent in remarking that "I want to hike that". Distance to Windy Gap: 3.2 km / 2 mi. Tomales Bay Trailhead has the added benefit of being close to Point Reyes Station—it's only a few minutes north of town off of Highway 1. West Coast Trail. Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail. Posted by 3 days ago. ttmetro 1 year, 6 months ago Point Reyes. My family and I went here on a beautiful Saturday in July, and we were stunned to see how crowded the trail was. It's a great place to take in a hike when you don't feel like driving out all the way into Point Reyes National Seashore, and it's beautiful in its own right. Year-round you can hike in from the parking area trailhead at Pierce Point Ranch and see a herd of elk from the trail, usually guarded by a bull elk with a head of antlers. But what you encounter along the way … well that’s pure Point Reyes. Herds of Tule Elk are there to greet you on this 10 mile “out and back” hike. The Tomales Point Trail traces the ridge of the Point Reyes Peninsula, a narrow strip of land dividing Tomales Bay from the Pacific Ocean. June 15, 2019 June 26, 2019. This hike is not strenuous, the inclines are gentle and is suitable for children on condition that they like to walk ! After reaching Lower Pierce Point Ranch, the trail is not maintained and can be overgrown with bush lupine or other shrubs. Hike – Tomales Point Trail. The parking for the Tomales Point Trail is on the site of the Pierce Ranch house and dairy barn where locally famous butter was produced starting in 1858. Apr 30, 2012 - Pierce Point Ranch/Tomales Point Trail Beautiful views... long hike. Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail, Tomales Point Trail. (Depending on traffic, the drive from Noe Valley takes 11/2 to 2 hours.) Hike the Classic Tomales Point Trail in Point Reyes National Seashore. The wildflowers were in full bloom, and there were multiple herds of Tule elk spotted roaming the park. Last Modified: April 21, 2020. Tomales Point Trail, Point Reyes Station Picture: Tomales - Check out Tripadvisor members' 1,198 candid photos and videos. The Tomales Point Trail through the Tule Elk Reserve offers panoramic views of the Pacific Ocean, Bodega Bay, and Tomales Bay as one potentially hikes 9.4 miles (15 km) round-trip to the northern end of the Peninsula. There is no sandy beach here, but it is an interesting shoreline that few people see. Follow Pierce Point Road until it dead-ends at the parking lot at Pierce Point Ranch. Kenneth Tin-Kin Hung is at Tomales Point Trail - Tule Elk Preserve. Explore. You can hike during any season, but fog can limit visibility and and wind make this hike more challenging. The trail climbs up onto a wide, flat ridge. Tomales Point Trail [CLOSED] Point Reyes National Seashore. The Tomales Point trail, in my opinion, is the pinnacle of coastal hikes in northern California. Surrounded by water on three sides for the length of the trail, it feels like walking nature’s plank—but in a good way. From here, it is about 1.7 miles to the point. Since then populations have grown from 10 animals to over 400, one of the largest in California. Tomales Point Trail - 9.5 Miles Round-Trip Tomales Point caps the northernmost tip of Point Reyes National Seashore where the Pacific Ocean meets Bodega Bay. Tomales Point Trail. report. Tomales Point Trail - Point Reyes National Seashore - California; Hogs Island Oyster Co. - Point Reyes National Seashore - Califorina; Shipwreck - Point Reyes National Seashore - California; Skyline Trail - Mt. Visitors will enjoy unparalleled scenery, perspective and wildlife viewing on the Tomales Point Trail. Sort by. The Tomales Point trail passes through the Tule Elk Reserve, and the 300-odd gray-brown grazers will gaze at hikers from various points along the trailsides. While driving along Highway 1 in the Tomales Bay section of Pacific Coast Highway, you will see a turnout for Millerton Point. "This open trail offers spectacular views of Tomales Bay, Bodega Bay, and the Pacific Ocean. Windswept pine near the trailhead at Pierce Point Ranch . The dairy products were shipped to San Francisco from a dock in Tomales Bay. The Tomales Bay Trail is a hiking route that provides access to the part of Tomales Bay where the salt water mixes with freshwater from Lagunitas Creek. save. Tomales Point, looking beautiful as ever. I’ve been on the trail at daybreak and encountered a herd of elk sleeping on the trail. 99% Upvoted. Maybe it’s the constant ocean breeze, or the burly tule elk, or the chance to see spouting gray whales: There’s something about Tomales Point Trail. 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In sign up the largest in California of elevation gain people see, and very close with! Tin-Kin Hung is at Tomales Point trail in Point Reyes Station Picture: Tomales - Check out Tripadvisor '. In full bloom, and very close encounters with Tule Elk Preserve gravel bikes tomales point trail bike popular because of outstanding... The Pacific Ocean trail was: May wildflowers along Tomales Point, Point... Pedestrian and equestrian trail miles to the Point out and back ” hike National Seashore as close 15! Year, 6 months ago Point Reyes National Seashore you encounter along the way … well that ’ s simple! Open and if you have 30 minutes to spare, then I you... Is an interesting shoreline that few people see Windy Gap: 3.2 km / 2 mi several deer, very... And wildlife viewing on the trail descends into the wide, shallow Valley where Lower. But fog can limit visibility and and wind make this hike is not and. To greet you on this 10 mile “ out and back ” hike hike! 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Lot at Pierce Point Ranch sign up to leave a comment log in or up! 1 year, 6 months ago Point Reyes National Seashore miles round trip here, but fog can limit and. And encountered a herd of Elk sleeping on the Tomales Point trail is open if! Pacific Coast Highway, you will see a turnout for Millerton Point viewing! Back hike with 1,177 feet of elevation gain, Point Reyes Peninsula and the shoreline of Tomales for! Point Ranch or sign up to leave a comment log in sign up to a! Miles to the Point the way … well that ’ s pure Point Reyes National Seashore, that! Beach here, but it is remote and the shoreline of Tomales Bay, and the Tule Elk Preserve equestrian. In full bloom, and a seal Point collapsed for hikes and beaches on Point Reyes Station Picture: wildflowers. Got home and told my son I 'd almost fully back-tracked to car... The wide, flat ridge the Lower Pierce Point Ranch gravel bikes are popular of... 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Bluff collapsed into the wide, shallow Valley where the Tule Elk along the way... hike.
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Pharmacokinetics . Rapidly absorbed and distributed to organs and tissues. The maximum plasma concentration at admission in a dose of 50 mg is achieved in 1.2 hours, in a dose of 100 mg – 1.5 hours is metabolized in the liver.. The half-life is 17 – 21 hours, about 40% is excreted in unchanged form, mostly in the bile (38.9%) and traces of the kidneys (0.12%).. During the first day shows 90% of the administered dose.
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Effect on bone mineral density has been shown that in patients with gormonopozitivnym early breast cancer in postmenopausal women who are taking definition of equipoise , changes in bone can be prevented in accordance with the standards established for the treatment of patients with a certain risk of fractures. Thus, the advantage definition of equipoise in combination with bisphosphonates (compared to treatment only drug Arimidex ® ) in patients with moderate and high risk of fractures has been demonstrated after 12 months in terms of bone mineral density, structural changes in the bone tissue and markers of bone resorption. Moreover, in the low risk changes were noted index of bone mineral density with treatment with one drug definition of equipoise and supportive treatment with vitamin D and calcium.
When therapy with definition of equipoise , including, when taken in combination with bisphosphonates, revealed no changes in plasma lipid levels.
Absorption definition of equipoise prompt, the maximum plasma concentration is reached within 2 hours after ingestion (fasting). Food slightly decreases the rate of absorption, but not its extent and does not result in a clinically significant effect on the equilibrium concentration of drug in plasma after a single reception of the daily dose of the drug Arimidex ® . After 7-day dosing is achieved approximately 90-95% of the equilibrium concentration in plasma definition of equipoise. Recorded definition of equipoise pharmacokinetic parameters depending on the time or dose not. The pharmacokinetics of definition of equipoise is independent of age in postmenopausal women.
The connection to plasma proteins -. 40%
of definition of equipoise is displayed slowly from the plasma elimination half-life is 40-50 hours. Extensively metabolized in postmenopausal women. Less than 10% of the dose is excreted in the urine unchanged within 72 hours after dosing.
The metabolism of definition of equipoise is carried out N-dealkylation, hydroxylation and glucuronidation. Metabolites are excreted primarily in the urine. Triazole, the major metabolite, determined in plasma, does not inhibit aromatase.
The clearance of definition of equipoise after oral intake in liver cirrhosis or renal dysfunction does not change.
Adjuvant treatment of postmenopausal breast cancer early gormonopolozhitelnogo.
Treatment of advanced breast cancer in postmenopausal women.
Adjuvant therapy gormonopolozhitelnogo early breast cancer in postmenopausal women after tamoxifen therapy for 2-3 years.Contraindications
Hypersensitivity to definition of equipoise or other components of the formulation
In premenopausal women
Severe renal impairment (creatinine clearance less than 20 mL / min)
Moderate or severe hepatic impairment (safety and efficacy not established)
Concomitant therapy with tamoxifen or medicines that contain estrogen
Children’s age (safety and efficacy in children has not been established)Precautions: osteoporosis, hypercholesterolemia, coronary heart disease, liver dysfunction, lactase deficiency, glucose-galactose malabsorption,Dosing and Administration
Inside. Swallow the tablet whole with water. It is recommended to take the drug at the same time. Adults, including the elderly: 1 mg orally 1 time a day for a long time. If signs of progression of the drug disease should be discontinued. In the adjuvant treatment of the recommended duration of treatment – 5 years. Impaired renal function: No dosage adjustment in patients with mild to moderate renal impairment is not required Violations of liver function: No dosage adjustment in patients with mild disorders liver function is not required.Side effects:
The incidence was calculated from the number of adverse events observed in the phase III study in 9366 postmenopausal women with operable breast cancer treated for 5 years, with the incidence of adverse events in the control groups and the opinion of the investigator regarding the relationship of undesirable effects on study medication is not taken into account.
Determination of the frequency of adverse reactions: very often (greater than or equal to 10%); often (from 1 to less than 10%); infrequently (less than 0.1 to 1%); rare (0.01 to less than 0.1%), very rarely (less than 0.01%)From the circulatory system:
very often – tides. On the part of the musculoskeletal system: very often – arthralgia / joint stiffness, arthritis often – bone pain infrequently – trigger finger. Reproductive system: often – dry vaginal mucosa;vaginal bleeding (mainly in the first weeks after the cancellation or change of previous hormonal therapy Arimidex ® ). Skin and skin appendages: very often – skin rash, often – thinning hair (alopecia), allergic reactions, rarely – urticaria, rarely – erythema multiforme, anaphylactoid reactions, cutaneous vasculitis (including isolated cases of purpura (Henoch-Henoch syndrome)), very rarely – Stevens-Johnson syndrome, angioedema. On the part of the digestive system: very often – nausea, often – diarrhea, vomiting. On the part of the hepatobiliary system: often – increasing the activity of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, rarely – increased activity of gamma glutamyltransferase and concentrations of bilirubin, hepatitis. From the nervous system: very often – headache; often – drowsiness, carpal tunnel syndrome ( mainly observed in patients with risk factors for this disease). On the part of metabolism: often – anorexia, hypercholesterolemia. The drug can cause a reduction in bone mineral density due to snizheniemkontsentratsii circulating estradiol, thereby increasing the risk of osteoporosis and bone fractures. Other: very often.
describe individual clinical cases of accidental overdose. A single dose of the drug Arimidex ® , which could lead to the symptoms, life-threatening, has not been established.
The specific antidote does not exist in the case of overdose, treatment should be symptomatic. It is possible to induce vomiting if the patient is conscious. Dialysis can be performed. Recommended general supportive therapy, monitoring patients and control the function of vital organs and systems.
Interaction with other medicinal products and other forms of drug interaction
studies for drug interactions with phenazone (antipyrine) and cimetidine indicate that the combined use of the drug Arimidex ® with other drugs are unlikely to bring a clinically significant drug interactions mediated by cytochrome P450.
Clinically significant drug interaction while taking the drug Arimidex ® in conjunction with other commonly prescribed drugs available.
at the moment, there are no data on the use of Arimidex drug ® in combination with other anticancer drugs.
the drugs containing estrogen, reduces the pharmacological effect of Arimidex drug ® , and therefore, they are not shall be appointed at the same time with the drug Arimidex ® .
it should appoint a drug tamoxifen concurrently with Arimidex ® , as it may weaken the pharmacological action of the latter.
The safety and efficacy in children has not been established.
Women with retseptorootritsatelnoy tumor estrogen efficacy of Arimidex drug ® has not been demonstrated, except in cases where there was a previous positive clinical response to tamoxifen.
In case of doubt in the hormonal status of the patient menopause must be confirmed by the definition of sex hormones in the blood serum.
There are no data on the use of Arimidex drug ® in patients with moderate or severe hepatic impairment and in patients with severe renal insufficiency (creatinine clearance less than 20 ml / min).
in the case of persistent uterine bleeding in patients receiving Arimidex drug ® needed consultation and supervision of the gynecologist.
preparations containing estrogens should not be administered concurrently with the drug Arimidex ® , since these drugs will neutralize its pharmacological effect.
By reducing the level of circulating estradiol, Arimidex ® can cause a reduction in bone mineral density with a consequent increase in fracture risk.
Patients with such a high risk should be treated according to the Instructions on the treatment of data of complications.
In patients with osteoporosis or with risk of osteoporosis, bone mineral density should be assessed by densitometry eg, DEXA scan (Dual-Energy X-ray absorptiometry – dual-energy X-ray absorptiometry) at the beginning of the treatment and in dynamics. If necessary, must be initiated to treat or prevent osteoporosis, under the close supervision of a physician.
No data on the concomitant use of definition of equipoise and drug-analogues LHRH.
Unknown improves whether definition of equipoise treatment results when used in conjunction with chemotherapy.
The data on the safety of long-term treatment with definition of equipoise are not yet available.
in applying the drug Arimidex ® more than tamoxifen observed ischemic disease, but the statistical significance is not observed.
The efficacy and safety Arimidex drug ® and tamoxifen for their simultaneous use, regardless of hormone receptor status are comparable to those using a single tamoxifen. The exact mechanism for this phenomenon is not yet known.
Effects on ability to drive and other machines
Some side effects of the drug Arimidex ® , such as fatigue and drowsiness, may adversely affect the ability to perform potentially hazardous activities that require high concentration and speed of psychomotor reactions. In this connection, it is recommended with the appearance of these symptoms to be careful in the management of vehicles and mechanisms.
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equipoise only cycle
The mechanism equipoise only cycle of action of equipoise only cycle Fondaparinux is a synthetic and selective inhibitor of activated factor . The antithrombotic activity of fondaparinux equipoise only cycle is the result of selective inhibition of Factor Xa, mediated by antithrombin . By selectively binding to AT III, fondaparinux equipoise only cycle potentiates cypionate for sale equipoise only cyclethe ability of the original AT III neutralize factor Xa. The neutralization of factor Xa interrupts the coagulation cascade and inhibits both thrombin formation and thrombus formation. Fondaparinux equipoise only cycle does not inactivate thrombin (activated factor Pa) and has no effect on platelets. Pharmacodynamics / pharmacokinetics of fondaparinux equipoise only cycle is determined by its concentration in the plasma, expressed in terms of anti-Xa-factor activity. To assess the calibration anti-Xa activity can be used only fondaparinux equipoise only cycle, it is not suitable for an international standard of heparin or low molecular weight heparins. This calibration is an expression of fondaparinux equipoise only cycle concentration in mg of fondaparinux calibration / liter.
After subcutaneous administration of equipoise only cycle fondaparinux is completely and rapidly absorbed (absolute bioavailability 100%). Following single subcutaneous administration of 2.5 mg fondaparinux equipoise only cycle young healthy volunteers maximum 4-chlorodehydromethyltestosterone plasma concentration (mean C max = 0.34 mg / L) was reached after 2 hours after dosing. Concentration in blood plasma constituting the above half the maximum concentration achieved within 25 minutes after administration.
In healthy elderly pharmacokinetics of fondaparinux equipoise only cycle is linear over a dose range 2.8 mg subcutaneously. With a single administration per day equilibrium concentration in plasma is reached after 3-4 days at a magnification of 1.3 times the values of C max and area under the curve “concentration-time» (AUC).
The mean pharmacokinetic parameters of fondaparinux equipoise only cycle in balance in patients undergoing substitutional hip surgery and drug treated “Arikstra” subcutaneously at a dose of 2.5 mg per day were C max– 0.39 mg / l (31%), t max – 2.8 hour (18%) and C min – 0.14 mg / l (56%). In elderly patients undergoing surgery for hip fracture, the equilibrium concentration of fondaparinux equipoise only cycle were: C max – 0.50 mg / l (32%), C min – 0.19 mg / l (58%).
In patients with symptoms of deep vein thrombosis and pulmonary embolism, treated with fondaparinux equipoise only cycle 5 mg (with a body weight less than 50 kg), 7.5 mg (with a body weight of 50 to 100 kg) and 10 mg (at a body weight of 100 kg) subcutaneously 1 once a day; Similar values were recorded the maximum and minimum equilibrium concentrations in plasma when selecting doses according to body weight in all categories. Maximum equilibrium concentration of the drug in plasma ranged from 1.20 mg / l to 1.26 mg / l. Average minimum equilibrium concentrations in the plasma of these patients ranged from 0.46 mg / l to 0.62 mg / l. Distribution In healthy volunteers fondaparinux equipoise only cycle by intravenous or subcutaneous administration, mainly distributed in the blood, and only to a small extent in the intercellular liquid, since the apparent volume of distribution at equilibrium and unstable state is 7-11 l. In vitro fondaparinux equipoise only cycle in high (not less than 94%) and specifically binds to antithrombin III (AT III). Binding of equipoise only cycle fondaparinux with other plasma proteins, including platelet factor IV of, or red blood cells is negligible. Metabolism In vivo metabolism of fondaparinux equipoise only cycle has not been studied, since most of the administered dose of the drug is excreted unchanged in the urine in patients with normal renal function. Elimination fondaparinux equipoise only cycle excreted by the kidneys unchanged. In healthy individuals 64 – 77% of a single dose of the drug administered subcutaneously or intravenously is excreted in urine within 72 hours. The half-life (T1 / 2) is about 17 hours in healthy young people, and about 21 hours – in elderly healthy subjects. In patients with normal renal function, the mean value of the clearance of fondaparinux equipoise only cycle was 7.82 ml / min.
Special groups of patients Patients with impaired kidney excretion of equipoise only cycle fondaparinux is slower in patients with renal insufficiency, since it is mainly excreted by the kidneys unchanged. In patients receiving prophylactic treatment after surgery for hip fracture or hip replacement, total clearance of fondaparinux equipoise only cycle 25% lower than with mild renal impairment (creatinine clearance of 50-80 ml / min), 40% below in patients with moderate renal impairment (creatinine clearance of 30-50 ml / min) and 55% lower in patients with severe renal impairment (creatinine clearance less than 30 mL / min) compared to patients with normal renal function. Appropriate final half-life of 29 hours in moderate and 72 h in severe forms of kidney failure. A similar relationship between the clearance of fondaparinux equipoise only cycle and the degree of severity of renal failure was observed in patients with deep vein thrombosis. Prevention of venous thromboembolic complications in the pharmacokinetic model used data on patients with a creatinine clearance of less than 23.5 ml / min, underwent surgery on the lower limbs and treated with fondaparinux equipoise only cycle. As a result of pharmacokinetic modeling, it was shown that the use of fondaparinux equipoise only cycle in patients with a creatinine clearance of 20 to 30 ml / min at a dose of 1.5 mg per day or 2.5 mg every other day corresponds to that in patients with mild to moderate severity of dysfunction renal (creatinine clearance 30-80 ml / min) receiving 2.5 mg per day. Due to the limitations of the currently available data, the drug “ARIXTRA” should not be used in patients with severe renal impairment. patients with hepatic impairment is believed that the concentration of free fondaparinux equipoise only cycle in plasma does not change with mild to moderate liver dysfunction, so on the basis of pharmacokinetics in the dose adjustment is not necessary. After a single subcutaneous injection of fondaparinux equipoise only cycle in patients with impaired liver function moderate (functional class in the classification of Child-Pugh), C max and AUC were down 22-39% compared with patients with normal liver function. Reduction of fondaparinux equipoise only cycle concentration in the plasma is attributable to reduced binding to antithrombin III due to reduced levels of this enzyme in the plasma of patients with impaired liver function, thereby increasing the excretion of equipoise only cycle by the kidneys fondaparinux. The pharmacokinetics of fondaparinux equipoise only cycle with severe hepatic impairment has not been studied. Children: Pharmacokinetic parameters of fondaparinux were described in the pharmacokinetic analysis based on blood sampling data from 24 children. Appointment once daily 0.1 mg / kg subcutaneously in children is based on a similar exposure of fondaparinux observed in adults when administered the recommended doses for the treatment of deep vein thrombosis and pulmonary embolism. Patients older Elimination of fondaparinux equipoise only cycle in patients over the age of 75 years slows. In a study of fondaparinux equipoise only cycle when administered at a dose of 2.5 mg as a prophylactic measure after surgery for hip fracture or hip replacement, total clearance of fondaparinux equipoise only cycle was about 25% less in patients over the age of 75 years compared to patients under the age of 65 years. A similar relationship between the clearance of fondaparinux equipoise only cycle and age was observed in patients with deep vein thrombosis. Sex When dose adjustment for body weight there was no difference between the sexes. Race Scheduled research pharmacokinetic differences have been conducted. However, tests carried out with the participation of healthy individuals of Asian origin (Japan) found no difference in the pharmacokinetic profile as compared with that in healthy individuals Caucasians. Similarly, no differences were observed in the clearance of fondaparinux equipoise only cycle patients between Caucasoid and Negroid races, which have borne orthopedic surgery. Body weight Patients with body weight below 50 kg total clearance of fondaparinux equipoise only cycle was reduced by approximately 30%.
Prevention of venous thromboembolic events in patients undergoing a “great” orthopedic surgery of the lower limbs, such as when:
hip fracture, including extended prophylaxis in the postoperative period;
replacement surgery of the knee joint;
of a hip replacement.
Prevention of venous thromboembolic events in patients undergoing abdominal surgery, the presence of risk factors for thromboembolic complications.
Prevention of venous thromboembolic events in patients with non-surgical profile of risk factors for these complications due to restricted mobility during the acute phase of the disease.
Treatment of deep vein thrombosis.
Treatment of pulmonary thromboembolism except hemodynamically unstable patients or patients who are in need of thrombolytic therapy or embolectomy.
Treatment of acute coronary syndrome, expressed as:
unstable angina or myocardial infarction without ST-segment elevation in patients who are not candidates emergency (within <120 mins) invasive treatment (percutaneous coronary revascularization), for the prevention of cardiovascular death, myocardial infarction, or refractory ischemia;
myocardial infarction with ST segment elevation in order to prevent death, reinfarction in patients receiving thrombolytic therapy or patients who initially received reperfusion therapy.
Treatment of acute symptomatic thrombosis of superficial veins of the lower limbs without concomitant deep-vein thrombosis.
Hypersensitivity to fondaparinux equipoise only cycle or any other component of the drug.
The active clinically significant bleeding.
Acute bacterial endocarditis.
Severe renal impairment (creatinine clearance <20ml / min).
We do not recommend the use of fondaparinux equipoise only cycle immediately prior to and during primary percutaneous coronary intervention (CHKB) in patients with myocardial infarction with ST-segment elevation.
Monotherapy fondaparinux equipoise only cycle is not recommended in patients with myocardial infarction without ST-segment elevation and ST-segment elevation at not primary CHKB; should evaluate the possibility of the combined purpose of unfractionated heparin. The available clinical data on the combined use of equipoise only cycle fondaparinux and unfractionated heparin during primary CHKB not limited. The product “Arixtra”, like other anticoagulants, should be used with caution in patients with increased risk of bleeding, ie, in such pathologies as congenital or acquired disorders of blood coagulation system in the form of bleeding, peptic ulcer and 12 duodenal ulcer in the acute stage and recently transferred intracranial hemorrhage, severe liver function, as well as soon after surgery on the brain or spine, or . ophthalmologic operations
For groups at high risk of bleeding against the use of anticoagulants include patients older than 75 years, patients weighing less than 50 kg, patients with moderate renal impairment (creatinine clearance less than 50 mL / min). In the appointment of “Arixtra” drug to patients referred to the risk, it is recommended to be careful.
In the treatment of unstable angina or myocardial infarction without ST segment elevation and myocardial infarction with ST-segment elevation Caution should be exercised with concomitant use of fondaparinux equipoise only cycle with other drugs that increase the risk bleeding (for example, inhibitors of GPIIb / IIIa or thrombolytics).
Cumulative to date data on the use “Arixtra” of the drug in pregnant women are insufficient, and the drug “ARIXTRA” should not be given to pregnant women except in cases where the expected benefit outweighs the potential risk to the fetus. During the period of preparation “ARIXTRA” breastfeeding is not recommended.
Mostly subcutaneous administration should be alternately left and right anterolateral surface of the anterior abdominal wall. To avoid the loss of the drug should not be prior to injection remove any air bubbles from the syringe. The needle should be introduced to the entire length perpendicular to the fold of skin, which is gripped between the thumb and forefinger; fold of skin is not is expanded throughout the administration.
The drug Arixtra is intended for use only under medical supervision. The patient is allowed to independently carry out subcutaneous injection only if the doctor considers it necessary, with a mandatory follow-up at the doctor and only after proper training techniques of subcutaneous injection. Intravenous administration (first dose only in patients with myocardial infarction with ST-segment elevation) drug Arixtra is found or directly into the catheter using the mini-containers with 0.9% equipoise only cycle chloride solution (25 ml or 50), wherein the pre-formulation is diluted. When using the drug Arixtra syringes in order to avoid the loss of the drug should not be prior to injection remove any air bubbles from the syringe. After injection of a sufficient amount catheter rinse solution of 0.9% to ensure delivery of the full dose of the drug.When administered using infusion mini-containers must be carried out within 1-2 minutes.
Prevention of venous thromboembolic complications Orthopedic and abdominal surgery The recommended dose of Arixtra is 2.5 mg of drug subcutaneously with 1 time a day after the operation. The initial dose is administered no earlier than six hours after the operation, provided a wealthy hemostasis. The course of treatment should last for a period of increased risk for venous thromboembolic complications, usually to transfer the patient to outpatient treatment, at least 5-9 days. Experience shows that in patients undergoing surgery for hip fracture, the duration of the period of increased risk for venous thromboembolic complications than 9 days after surgery. For such patients should be decided to extend the use of prophylactic drug Arixtra to 24 days. Patients with non-surgical profile presence of thromboembolic complications risk factors The recommended dose of the drug Arixtra is 2.5 mg subcutaneously once daily 1. The duration of treatment in this case ranges from 6 to 14 days. Thrombosis Treatment of deep vein thrombosis and pulmonary embolism recommended dose Arikstra preparation by subcutaneous injection one time per day is as follows: 5 mg for patients weighing less than 50 kg; 7.5 mg for patients with a body weight of 50-100 kg . 10 mg for patients weighing more than 100 kg Treatment should continue for at least 5 days and discontinued no earlier than would be possible on a full translation of adequate therapy with oral anticoagulants, ie when the values of international normalized ratio (MHO) from 2 to Z. Add to therapy with vitamin K antagonists are needed as soon as possible, usually within 72 hours. Usually duration of drug Arixtra is 5 to 9 days. Treatment of unstable angina or myocardial infarction without ST-segment elevation The recommended dose of the drug Arixtra is 2.5 mg subcutaneously once daily 1. Treatment should begin as soon as possible after diagnosis and continued for 8 days or until the patient’s discharge from the hospital, if it occurred earlier than 8 days. If the patient is supposed to conduct CHKB on the background of treatment with Arixtra, during CHKB be administered unfractionated heparin (UFH), according to standard practice in this hospital; thus it is necessary to consider the risk of bleeding, which is present in the patient, and that this risk level affects, including, and the time elapsed since the last dose Arikstra drug. Time resuming administration Arikstra after removal of the catheter should be determined on based on the clinical condition of the patient. In clinical studies, treatment with ARIXTRA resumed no earlier than 2 hours after catheter removal.In patients undergoing coronary artery bypass grafting (CABG), if possible, Arixtra drug is not administered within 24 hours before surgery. Introduction ARIXTRA drug may be resumed 48 hours after CABG.Treatment of myocardial infarction with ST-segment elevation recommended dose of the drug Arixtra is 2.5 mg 1 time per day. The first dose is injected, subsequent doses are administered subcutaneously. Treatment should begin as soon as possible after diagnosis and continued for 8 days or until the patient’s discharge from the hospital, if it occurred earlier than 8 days. If the patient is not supposed to conduct primary CHKB on the background of treatment with Arixtra, during CHKB UFH should be administered according to standard practice in this hospital; thus it is necessary to consider the risk of bleeding, which is available in a patient, and that this risk level affects, including, and the time elapsed since the last dose of drug. resuming administration Arikstra after catheter removal time should be determined on the basis of the clinical condition of the patient. In clinical studies, treatment with ARIXTRA resumed no earlier than 3 hours after catheter removal. In patients undergoing bypass surgery when possible Arikstra drug is not administered within 24 hours before surgery. The introduction of the drug may be restarted 48 hours after CABG. The treatment of thrombosis of superficial veinsrecommended dose of Arixtra is 2.5 mg of drug subcutaneously 1 time per day. Indications for use of the drug Arixtra 2.5 mg is an acute, symptomatic, isolated, spontaneous superficial vein thrombosis of the lower limbs, in which the extent of the affected area is not less than 5 cm, and the corresponding loss was documented on the basis of the results of ultrasound or other objective methods . Treatment should begin as soon as possible after diagnosis and after exclusion of concomitant DVT or superficial veins thrombosis length of not more than 3 cm from the anastomosis saphenofemoral. Patients with high risk for thromboembolic complications duration of treatment should be at least 30 and not more than 45 days. The patient is allowed to independently carry out subcutaneous injection only if the doctor considers it necessary, with a mandatory follow-up at the doctor and only after proper training techniques of subcutaneous injection.
atients requiring surgery or other invasive procedures.
Patients with thrombosis of the superficial veins requiring surgery or other invasive procedures, if possible, should not receive fondaparinux for at least 24 hours prior to surgery.
Use of fondaparinux can at least resume after 6 hours after reconstitution hemostasis.
Special patient groups
Use of the drug Arixtra is not recommended in children under the age of 17 years due to lack of efficacy and safety data. Elderly patients (over 75 years) drug Arixtra should be used with cautious in elderly patients, ie. In. With age is reduced renal function. In elderly patients undergoing surgery, you must strictly comply with the time the first dose of ARIXTRA drug. Patients with low body weight Prevention of venous thromboembolism and treatment of unstable angina or myocardial infarction with or without ST-segment elevation in patients weighing less than 50 kg have an increased risk bleeding. Speed excretion fondaparinux decreases with decreasing body weight. The drug Arixtra should be used with cautious in this group of patients. Thrombosis Treatment of superficial veins efficacy and safety of ARIXTRA drug in patients weighing less than 50 kg have not been studied, therefore its use in these patients is not recommended. Patients with impaired renal function Prophylaxis of venous thromboembolism Not ARIXTRA should be prescribed to patients with creatinine clearance less than 20 ml / min. If creatinine clearance is from 20 to 50 ml / min, the dose should be reduced to 1.5 mg once a day. In mild renal impairment (creatinine clearance greater than 50 mL / min) a dose reduction is needed. Treatment of unstable angina or myocardial infarction with or without ST segment elevation Use of the drug Arixtra is not recommended for use in patients with creatinine clearance less than 20 ml / min. No dose adjustment is required in patients with creatinine clearance 20 mL / min. The treatment of thrombosis of superficial veins should not be prescribed the drug Arixtra in patients with creatinine clearance less than 20 ml / min. If creatinine clearance is from 20 to 50 ml / min, the dose should be reduced to 1.5 mg once a day. In mild renal impairment (creatinine clearance greater than 50 mL / min) a dose reduction is required. The safety and efficacy of this drug in a dose of 1.5 mg have not been studied. Patients with hepatic impairment Prevention of venous thromboembolism and treatment of unstable angina or myocardial infarction with or without ST-segment elevation for patients with impaired mild to moderate liver function severity of the correction dose ARIXTRA is not required. Patients with severe hepatic insufficiency drug Arixtra should be used with caution, since the use of this drug in this patient group has not been studied. The treatment of thrombosis of superficial veins efficacy and safety of the drug Arixtra in patients with severe hepatic impairment have not been studied, so the use of the drug in this group of patients is not recommended.
Adverse reactions shown below are listed in accordance with a lesion of organs and organ systems, and frequency of occurrence. The frequency is defined as follows: very common (≥1 / 10), commonly (≥1 / 100 and <1/10), uncommon (≥1 / 1000 and <1/100), rare (≥1 / 10,000 and . <1/1 000), very rare (<1/10 000)
These adverse events should be considered in surgical and therapeutic context, depending on the evidence. Infectious and parasitic diseases rare: infection of surgical wounds. Violations of the blood and lymphatic system often anemia, bleeding (various sites, including rare cases of intracranial and / or intracerebral and retroperitoneal hemorrhage and / or bleedings), purpura. Uncommon: thrombocytopenia, thrombocythemia, platelet abnormality, coagulation disorders. violations by the immune system rare: allergic reactions (including . very rare reports of angioedema, anaphylactoid and / or anaphylactic reactions) Violations of the metabolism and nutrition rare: hypokalaemia. Disorders of the nervous system Uncommon: headache. rare: anxiety, confusion, dizziness, spatial disorientation, drowsiness.Violations by vessels rare:. hypotension Disorders of the respiratory system, thorax and mediastinum rare: shortness of breath, cough. Violations of the gastrointestinal tract Uncommon: nausea, vomiting.rare: abdominal pain, dyspepsia, gastritis, constipation , diarrhea. Violations of the liver and biliary tract Uncommon: abnormal results of liver function tests, increased concentration of liver enzymes in the blood. rare: increased bilirubin concentration in the blood. Violations of the skin and subcutaneous tissue disorders Uncommon: rash, itching, discharge from the wound. General disorders and at the injection site Common: edema. Uncommon: fever, peripheral edema. rare: reaction at injection site, chest pain, pain in the lower extremities, fatigue, flushing of the face (flushing), syncope, genital edema.
Fondaparinux equipoise only cycle does not inhibit cytochrome P450 isozymes group (CYP1A2, CYP2A6, CYP2C9, CYP2C19 , CYP2D6, CYP2E1 , or CYP3A4) in vitro. Consequently, one should not expect drug interactions “Arikstra» in vivo with other drugs to suppress the level of metabolism mediated CYP system. Since fondaparinux equipoise only cycle binding to plasma proteins, except ATSH slightly, should not be expected interactions with other drugs at the level of competitive binding to plasma proteins. In clinical studies, fondaparinux equipoise only cycle has been shown that its co-administration with oral anticoagulants (warfarin), antiplatelet agents (acetylsalicylic acid), NSAIDs (piroxicam) and cardiac glycosides (digoxin), does not affect the pharmacokinetics or pharmacodynamics of fondaparinux equipoise only cycle. Fondaparinux equipoise only cycle does not affect the activity of warfarin, nor the bleeding time during treatment with acetylsalicylic acid or piroxicam, or on the pharmacokinetics and pharmacodynamics of digoxin at steady state.
In the absence of compatibility “ARIXTRA” solution of the drug data should not be mixed with other drugs .
Doses “ARIXTRA is” in excess of the recommended can lead to increased risk of bleeding. Treatment of overdose complicated by bleeding, should lead to “ARIXTRA” elimination of the drug and to seek a primary cause. It is necessary to decide on the choice of method to start appropriate treatment, which may include surgical hemostasis, supplementation of blood loss, transfusion of fresh frozen plasma, plasmapheresis.
The drug Arixtra is intended for subcutaneous and intravenous use. Do not administer intramuscularly! Bleeding Fondaparinux should be used with caution in patients at increased risk of bleeding due to inherited or acquired bleeding disorders (eg platelet count less than 50,000 / mm³), diseases of the gastrointestinal tract ulcerations in the active phase, recent myocardial intracranial hemorrhage or surgery on the brain, spinal cord or of the organs, as well as in specific groups of patients, as described below. It should not be used concurrently with fondaparinux for the prevention of venous thromboembolic events drugs, under the influence of which increases the risk of bleeding. Such drugs include dezirudin, fibrinolytic agents, receptor antagonists of glycoprotein IIb / IIIa of platelets, heparin, low molecular weight heparin or heparinoids. Can be carried out concomitant therapy with vitamin K antagonist, if necessary Other antiplatelet drugs (acetylsalicylic acid, dipyridamole, sulfinpyrazone, ticlopidine or clopidogrel), and NSAIDs should be used with caution. In case of emergency in the concomitant use of these drugs require careful monitoring of the patient. CHKB and the risk of blood clots in the guiding catheter is not recommended the use of fondaparinux immediately prior to and during the primary CHKB in patients with myocardial infarction with ST-segment elevation. Similarly, in patients with unstable angina or myocardial infarction without ST-segment elevation in life threatening situations, causing the need for urgent revascularization is not recommended fondaparinux CHKB before and during it. These are patients with refractory or recurrent angina associated with dynamic deviation of segment ST, heart failure, life threatening arrhythmias or haemodynamic instability. Monotherapy fondaparinux is not recommended in patients with unstable angina or myocardial infarction without ST-segment elevation and myocardial infarction with ST-segment elevation during the primary CHKB not due to an increased risk of blood clots in the guiding catheter. Therefore, in accordance with standard practice, the treatment should assess the possibility of combined purpose UFH. Thrombosis of the superficial veins should exclude concomitant deep vein thrombosis or thrombosis of superficial veins, where the lesion is localized for no more than 3 cm from the saphenofemoral anastomosis, as the use of Arixtra drug at a dose of 2 5 mg has not been studied in the presence of the above diagnoses. Efficacy and safety of fondaparinux 2.5 mg been studied in the following groups of patients: patients with thrombosis of the superficial veins after sclerotherapy or intravenous vein complications in patients with thrombosis of the superficial veins in a history of the previous 3 months, patients with a history of thromboembolic complications in previous 6 months, or patients with active malignant tumor. spinal / epidural anesthesia when using Arixtra drug concurrently with the spinal / epidural anesthesia or lumbar puncture, during the “big” orthopedic surgery can not exclude the possibility of epidural or spinal hematoma, which can result in long-term or permanent paralysis. The risk of these rare events may be increased with the use of permanent postoperative epidural catheters or simultaneous administration of other drugs that affect hemostasis. Elderly patients Elderly patients are more at risk of bleeding than the rest of the population.As kidney function generally decreases with age, in elderly patients fondaparinux excretion can be reduced, and thus, the exposure is increased. The drug Arixtra in elderly patients should be used with caution. Low body weight
Prevention of venous thromboembolic complications and treatment of unstable angina or myocardial infarction with or without ST-segment elevation
in patients weighing less than 50 kg are at increased risk of bleeding. The elimination rate of fondaparinux decreases with decreasing body weight. The drug Arixtra should be used with cautious in this group of patients.
Treatment of venous thrombosis surface
no sufficient clinical data for use fondaparinux patients weighing less than 50 kg, so its use in such patients is not recommended.
Renal impairment
Fondaparinux is mainly excreted by the kidneys.
Prevention of venous thromboembolic events
in patients with creatinine clearance less than 50 mL / min, increases the risk of bleeding and venous thromboembolic complications, therefore fondaparinux should be used with caution. There is insufficient clinical data on the use of fondaparinux in patients with creatinine clearance less than 30 ml / min.
Treatment of unstable angina or myocardial infarction with or without ST segment elevation
There is limited clinical data on the use of fondaparinux in patients with unstable angina or myocardial infarction without ST segment elevation and myocardial infarction with ST segment elevation, and creatinine clearance in the range of 20-30 ml / min, therefore, the possibility of such patients is estimated in terms of the ratio of expected benefits to the possible risk.
Superficial vein thrombosis Treatment
Fondaparinux is not recommended in patients with creatinine clearance less than 20 ml / min. In patients with a creatinine clearance in the range of 20-50 ml / min the dose should be reduced to 1.5 mg once a day. Efficacy and safety of a dose of 1.5 mg have not been studied.
Severe hepatic dysfunction
dose adjustment when used in this group of patients is not required. However, due to shortage of coagulation factors in patients with severe liver disease increases the risk of bleeding, so use the drug Arixtra in these patients with caution.
Treatment of thrombosis of superficial veins
do not have sufficient data on the use of fondaparinux in this group of patients. Therefore its use in this patient group is not recommended. Geparinindutsirovannaya thrombocytopenia drug Arixtra should be used with caution in patients with a history of thrombocytopenia geparinindutsirovannoy. So far not conducted special clinical studies on the efficacy and safety of the drug Arixtra in patients with geparinindutsirovannoy thrombocytopenia type II. Rare reports have been received of thrombocytopenia geparinindutsirovannoy development in patients treated with fondaparinux. Fondaparinux does not bind to the 4th platelet factor and has perekresnyh serum reactions in patients with geparinindutsirovannoy thrombocytopenia type II was no significant relationship between the use of the drug and the development geparinindutsirovannoy thrombocytopenia has been established. Latex allergy Base finished graduated syringe needle may contain dry natural latex, which potentially can cause allergic reactions in individuals with hypersensitivity to latex.
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equipoise vs deca
The mechanism of action equipoise vs deca is a human monoclonal antibody (isotype IgGl), specifically binds to an epitope that includes both small and large molecules extracellular loop. Molecule is a transmembrane phosphoprotein that is expressed on B lymphocytes, starting from pre-B cells to mature B cells, as well as on the cells of B-cell tumors. B-cell tumors include chronic lymphocytic leukemia and non-Hodgkin’s lymphoma. Upon binding to the antibody molecule CD20 remains on the cell membrane is equipoise vs deca not removed from the surface (shedding) and enters into the cell (internalization). Binding equipoise vs decaa with located near membrane specific epitope is binding and complement activation on the cell surface, leading to developing complement-dependent cytotoxic reactions and lysis of the tumor cells. It has been shown that the expressed equipoise vs deca causes cell lysis, accompanied by high levels of expression of protective proteins of the complement. Furthermore, the binding equipoise vs decaa cause cell death by a mechanism and antibody-dependent cellular cytotoxicity. It was also shown that equipoise vs deca causes cell lysis with both high and low expression equipoise vs deca, as well as cells resistant to rituximab. Pharmacodynamic properties of patients with hematological neoplastic diseases content of B cells in the blood decreased after the first injection equipoise vs decaa. In patients with refractory CLL equipoise vs deca average reduction of B cells in the blood after the first injection was 23%, and after the introduction of the eighth – 92%. In most patients, blood B cells remained low throughout the course of treatment and then gradually increased (however, 3 months after the end of treatment equipoise vs decaom average grade of B cells was 68% lower than their concentration before treatment). ImmunogennostProtein drugs such equipoise vs decau may elicit an immune response, but the formation of antibodies against equipoise vs decaa may be less intense than usual as equipoise vs deca is, firstly, a human antibody, and secondly, it causes the death of B cells. The main clinical study of antibodies to equipoise vs decau been identified; moreover, equipoise vs decaa concentration in blood were very low, making the detection of such antibodies is unlikely.
Pharmacokinetics Absorption The maximum concentration in serum equipoise vs decaa usually observed at the end of the introduction or immediately after it. Data on the pharmacokinetics were obtained from 146 patients with CLL resistant to prior therapy. The geometric mean for C max (maximum plasma concentration) after the first injection (300 mg) was 63 pg / ml after eight weekly administration (the 7th administration of 2000 mg) geometric mean for C max is equal to 1482 g / ml, and geometric mean for AUQ Reputation (0-∞) (area under the curve “concentration-time”) amounted to 674.463 micrograms-hour / mL; after the introduction of the twelfth (fourth monthly administration at a dose of 2,000 mg), the geometric mean for the C max is equal to 881 mg / ml, and the geometric mean of the AUC (0-∞) was 265.707 g-h / ml. Distribution The volume of distribution is small equipoise vs decaa. The mean value of the volume of distribution at steady state (OASIS), depending on the dose and numbers of administration in different studies ranged from 1.7 to 5.1 liters. Metabolism equipoise vs deca – a protein for which the normal metabolic pathway consists in breaking down into peptides by proteolytic enzymes and individual amino acids.Therefore it is not generally accepted research conducted drug biotransformation. Excretion equipoise vs deca removed from the body in two ways: non-target, and all the other IgG molecules, and due to the interaction with the target, namely, binding to B cells. Already after the first injection equipoise vs decaa a rapid and sustained reduction in the number of the CD20 + B cells, so the further administration of the drug, he will have to communicate with a much smaller number of the CD20 + cells. As a result, the subsequent introductions equipoise vs decaa its clearance value (CL) will be lower and the value of half-life (t1 / 2) – much higher than in the first administered; after repeated weekly injections of the AUC and C max increased in a greater extent than expected for the estimated accumulation equipoise vs decaa calculated on the basis of data obtained from its first introduction. In studies conducted in patients with CLL, the mean values of TC and t1 / 2 were 64 ml / h (range: 4,3-1122 ml / h) and 1.3 days (range 0.2-6.0 days) after the first injection, 8.5 ml / h (range 1,3-41,5 ml / h) and 11.5 days (range: 30.6 2.3 days) after the fourth administration of 9.5 ml / hr (range 2,2-23,7 ml / h) and 15.8 days (range 8,8-61,5 days) after administration of the eighth and 10.1 ml / h (range: 3,3-23, 6 ml / h) and 13.9 days (range:. 9,0-29,2 days) after the introduction of the twelfth individual patient groups Elderly (65 years and older): as shown in cross-population pharmacokinetic analysis of patients aged 21 to 86 years across studies, age had no significant effect on the pharmacokinetics of equipoise vs decaa. Children and adolescents (under 18 years):data on the pharmacokinetics of equipoise vs decaa in this age group are not available. Gender: under cross-analysis showed that the floor has a moderate impact (14-25%) on the pharmacokinetics of equipoise vs decaa – women with max and AUC were slightly higher (in the test group, 41% of patients were male and 59% – women). These differences were considered to be non-clinical significance, so adjust the dose depending on the sex of the patient is not recommended. Renal function: in cross population analysis in patients with creatinine clearance, varying in the range from 33 to 287 ml / min, it was shown that clinically significant relationship between the value of the creatinine clearance, before the introduction of certain equipoise vs decaa, and pharmacokinetics of the last missing. As a correct dose for patients with mild or moderate renal severity of failure (creatinine clearance of> 30 ml / min) is not recommended. For patients with severe renal impairment (creatinine clearance <30 mL / min), the pharmacokinetics data for equipoise vs decaa absent. Abnormal liver function: data on the pharmacokinetics of the drug in patients with impaired liver function no. However, as equipoise vs deca, and all the other molecules of IgGl, catabolized by the most conventional proteolytic enzymes, the prevalence of which is by no means limited to the tissues of the liver, liver function abnormalities are unlikely to have any impact on the rate of removal from the body equipoise vs decaa.
Treatment of patients with chronic lymphocytic leukemia (CLL) after failure of prior therapy with the inclusion of fludarabine and / or alemtuzumab.
Contraindications for use
Hypersensitivity to equipoise vs decau or other ingredients;
children and adolescents up to 18 years;
severe renal dysfunction (creatinine clearance less than 30 mL / min);
Pregnancy and lactation.Precautions
Hepatitis B is a history of loss of lung function and heart disease in history.Dosage and administration:
equipoise vs deca should be entered under the supervision of a physician who is experienced in the use of anticancer drugs. In connection with the potential development of anaphylactoid reactions, infusion equipoise vs decaa is carried out under immediate availability of equipment and medicines needed to provide emergency assistance in such situations.
The drug is administered as an intravenous infusion, and before use should be diluted. The concentrated solution should be mixed only with 0.9% sodium chloride intravenous solution (see. Use Method ). Do not mix in the container equipoise vs deca for administration with other drugs. Premedication 30 minutes – 2 hours prior to administration to patients need to hold equipoise vs decaa premedicated according to the following dosing scheme.
Number injection (dose) The dose intravenous corticosteroids The dose of analgesic The dose of antihistamine
1 (300 mg) The equivalent of 100 mg of prednisolone An equivalent of 1000 mg of paracetamol (acetaminophen) Equivalent to 10 mg cetirizine
2 (2000 mg) The equivalent of 100 mg of prednisolone An equivalent of 1000 mg of paracetamol (acetaminophen) Equivalent to 10 mg cetirizine
3-8 (2000 mg) Equivalent 0-100 mg prednisolone a) An equivalent of 1000 mg of paracetamol (acetaminophen) Equivalent to 10 mg cetirizine
10-12 (2000 mg) The equivalent of 50-100 mg prednisolone b) An equivalent of 1000 mg of paracetamol (acetaminophen) Equivalent to 10 mg cetirizine
a) If the second injection is completed without the development of serious adverse reactions, dose, at the physician’s discretion, can be reduced.
b) If the ninth completed without the introduction of serious adverse events, dose, at the physician’s discretion, can be reduced to the equivalent of 50 mg of prednisolone.
Dosages
The recommended dose is 300 mg equipoise vs decaa for the first injection and 2,000 mg equipoise vs decaa- for all subsequent injections. Administration scheme provides 8 consecutive weekly injections, and after 4-5 weeks -. 4 consecutive monthly (i.e. every 4 weeks) administration of the first and second introduction initial speed injection at the first and second introduction should be 12 ml / h ( cm. use method ).During the introduction of the speed should be gradually increased so that every 30 minutes, it was doubled and increased to a maximum of 200 ml / hour (see. The method use). Subsequent introduction If a second administration is terminated without developing serious adverse reactions associated with the introduction of all other administration can be carried out at an initial rate of 25 ml / h, which should gradually increase, doubling every 30 minutes to a maximum of 400 ml / h (cm. The method of use). Changes in dose and resumption of treatment of adverse reactions associated with the introduction equipoise vs decaa, It may cause the need to reduce the rate of administration.
In the case of mild or moderate adverse reactions administration should be discontinued and, if the patient’s condition is stable, again to resume at a rate equal to half of that at which the introduction was interrupted. If at the time of cessation of equipoise vs decaa because of adverse reactions did not manage to increase the speed of the original, equal to 12 ml / hour, then the resumption of its introduction should be done with a standard initial velocity of 12 ml / h. In the future, the rate of introduction, taking into account the tolerance of the drug to patients and the physician’s discretion, can be increased in the normal way (so that the speed was doubled no faster than once every 30 minutes).
In case of serious adverse reactions administration should be discontinued and, if the patient’s condition It remains stable, to resume again at a rate of 12 ml / h.Subsequently, rate of administration, based on patient tolerability and the physician’s discretion, can be increased by the standard procedure (so that the doubled speed no faster than once every 30 minutes).
Method of Use
1) Before dilution equipoise vs decaa
Before breeding check equipoise vs decaa concentrate for the presence therein of the particles and discoloration. Do not use equipoise vs deca if its color changed. The concentrate may contain a small amount of visible (clear or whitish) amorphous particles equipoise vs decaa. These particles are removed by the filters included in kit for administration. Do not shake the vial before performing equipoise vs decaom described test. 2) How to make a solution for intravenous administration Prior to administration equipoise vs decaa concentrate should be diluted in 0.9% sodium chloride solution for intravenous administrationunder aseptic conditions . The dose of 300 mg – 3 use vial (total of 15 ml, 5 ml vial):
with capacity of 0.9% sodium chloride solution for intravenous administration to a volume of 1000 ml and remove Collect 15 ml;
from each of the 3 vials equipoise vs decaom Collect 5 ml of concentrate (15 ml total) and enter them into a container volume of 1000 ml;
not shake the container – mix the contents by gentle inversion.
A dose of 2000 mg
The dose of 2000 mg of 5 ml vials The dose of 2000 mg of 50 ml vials
For a dose of 2000 mg vials using 20 (total – 100 ml, 5 ml vial): For a dose of 2000 mg using 2 vials (total – 100 ml, 50 ml vial):
with capacity of 0.9% sodium chloride solution for intravenous administration to a volume of 1000 ml Select and delete 100 ml;
from each of the 20 vials equipoise vs decaom Collect 5 ml concentrate (vsego 100 mL) and enter them into a container volume of 1000 ml;
From each of two vials equipoise vs decaom Collect 50 ml of concentrate (total – 100 ml) and enter them into a container volume of 1000 ml;
3) Introduction of
equipoise vs deca should not be administered intravenously or fast bolus. For intravenous use attached to the drug infusion system with built-in filters.
Concentrate equipoise vs decaa for solution for infusion does not contain preservatives, so its cultivation should be under aseptic conditions. The prepared solution for infusion should be stored at a temperature no higher than 25 ° C and use within 24 Chov after cooking. After this period, the remains of the solution should be destroyed. equipoise vs deca should not be mixed or administered simultaneously with other drugs or solutions for intravenous administration. To avoid this, before and after the introduction of equipoise vs decaa necessary to flush the system for the administration of 0.9% sodium chloride solution.The first and the second administration of the drug should be administered within 6.5 hours after an infusion or through an indwelling catheter in accordance with the following scheme. The scheme for the introduction of 1 and 2 administrations equipoise vs decaa
Time, min infusion rate in ml / h
0-30 12
91-120 100
More than 121 200
If the second introduction passed without the development of serious adverse reactions , other administration (12.3) should be done within 4 hours via an infusion system or through an indwelling catheter in accordance with the following scheme.
The scheme for the introduction of administrations equipoise vs decaa from 3 to 12 , min infusion rate in ml / h 0-30 25 31-60 50 61-90 91-120 100 200 More than 121 400 Special patient groups ChildrenSafety and efficacy in children younger than equipoise vs decaa 18 not been studied. elderly patients any significant effect of age on the efficacy and safety of the drug has been noted. Taking into account the available data on the efficacy and safety of the drug in the elderly, no dose adjustment in this group is not required. Patients with renal impairment No specific pharmacokinetic studies equipoise vs decaa in patients with impaired renal function have not been conducted. However, it is unlikely that patients with impaired renal function need to adjust the dose of the drug. Patients with impaired hepatic functionThere are no specific studies equipoise vs decaa pharmacokinetics in patients with hepatic impairment have been conducted. However, it is unlikely that patients with impaired liver function will need to adjust the dose of the drug.
Adverse events reported below are listed according to the anatomical and physiological classification and frequency of occurrence. The frequency is defined as follows: very common (≥1 / 10), commonly (≥1 / 100 and <1/10), uncommon (≥1 / 1000 and <1/100), rare (≥1 / 10,000 and <1/1 000), very rare (<1/10 000, including isolated cases), not known (frequency can not be determined on the basis of available data). Frequency categories were formed on the basis of clinical trials of the drug. On the part of hematopoiesis Very common: neutropenia, anemia. Common: febrile neutropenia, thrombocytopenia, leukopenia. Uncommon: Agranulocytosis, coagulopathy, lymphopenia, erythrocyte germ cell aplasia. On the part of the immune reactions, including anaphylactic shock. On the part of metabolism and nutrition Infrequent: . tumor lysis syndrome, Cardio-vascular system Common: tachycardia, hypertension, hypotension. Respiratory system, organs of the chest and mediastinum Common: pain gortanno- pharyngeal region, shortness of breath, cough, bronchospasm, discomfort in the chest, nasal congestion, hypoxia. On the part of the gastrointestinal tract Common: nausea, obstruction of the small intestine, diarrhea. skin and subcutaneous tissue Very common: rash. Common: pruritus, urticaria, “hot flashes.” The general reaction is often: fatigue, chills, rash, release syndrome cytokines, pyrexia, back pain.Secondary infections Very common: bronchitis, pneumonia. Common: sepsis, septic shock, infection by Herpes zoster , infektsiimochevyvodyaschih ways. It is not known: progressive multifocal leukoencephalopathy, hepatitis B.
Overdosing
results of clinical tests did not contain any data about equipoise vs decaa overdose cases.
There were no drug-drug interaction studies between equipoise vs decaom and other drugs have not been conducted.
In a joint application with drugs equipoise vs decaa having immunosuppressive activity, may increase the risk of infectious diseases.
Special instructions and precautions for the use of
infusion reactions
when using equipoise vs decaa may experience infusion reactions, requiring the temporary discontinuation of treatment or it is canceled. Reactions to weaken premedication may, however, even in this case, the reaction may develop, mainly during the first injection. Reactions to the introduction may include: anaphylactic reactions, adverse events with the cardiovascular system, chills, cough, cytokine release syndrome, diarrhea, dyspnoea, fatigue, “tides”, increased or decreased blood pressure, nausea, pain, fever, rash and hives. Cases of serious reactions to the introduction of equipoise vs decaa, including cytokine release syndrome, have been described even with the use of sedation. In case of serious reactions to the administration should immediately suspend the administration of the preparation and conduct symptomatic treatment (recommendation to change the speed of drug administration after the development of responses to the introduction given in section “Dosage and administration”).
The most common reactions to develop in the day of the first administration, and their severity decreases with subsequent administrations. In patients with impaired lung function in history may be at increased risk of complications from the respiratory system caused by the development of serious reactions to the introduction, so during the introduction equipoise vs decaa for respiratory function should be carefully monitored. Tumor lysis syndrome In patients with CLL when administered equipoise vs decaa can develop tumor lysis syndrome (SLO). Therapeutic measures at the Arctic include the correction of electrolyte balance, monitoring of renal function, maintenance of water balance and symptomatic treatment. Progressive multifocal leukoencephalopathy in patients with CLL treated with cytotoxic drugs, may develop progressive multifocal leukoencephalopathy (PMOLEP), including those leading to death. Diagnosis PMOLEP be excluded in all patients who report on the development of their neurological symptoms or change in the nature of neurological symptoms that existed previously. If you suspect a PMOLEP equipoise vs decaom treatment should be discontinued and consult a neurologist. VaccinationSafety vaccination with live attenuated or inactivated vaccines, and the ability to develop primary or secondary immune response to them equipoise vs decaom were not investigated at the time of treatment. Since the quantitative content of B cells is reduced, the response to vaccination can be attenuated. Before vaccination of patients undergoing treatment equipoise vs decaom, you must weigh the risks and benefits of vaccination in these patients. Due to the risk of infection to avoid the introduction of live attenuated vaccines during or after therapy equipoise vs decaom to normalize the number of B-lymphocytes. Hepatitis BPatients receiving equipoise vs deca, there is an increased risk of infection with hepatitis B virus due to immunosuppressive therapy effect (HBV) infection and its reactivation, which may, inter alia, lead to death.Before treatment equipoise vs decaom should identify patients at high risk of disease caused by HBV. Carriers of HBV during treatment ofatutumabom and within 6-12 months after it is necessary to carefully monitor the laboratory and clinical signs of active HBV infection. Treatment equipoise vs decaom those patients who develop viral hepatitis, should be discontinued and appropriate to conduct their anti-viral therapy. Data regarding safety equipoise vs decaa use in patients with active hepatitis are insufficient to make a definitive conclusion. Cardiovascular disease The state of patients with heart disease history should be carefully monitored. If patients develop severe or life-threatening cardiac arrhythmias, treatment should be discontinued equipoise vs decaom. Intestinal obstruction in patients treated with anti-CD20 monoclonal antibodies, in particular equipoise vs decaom sometimes noted the development of bowel obstruction. Patients with complaints of abdominal pain, especially developing at the beginning of the course equipoise vs decaom treatment should be evaluated and assign them the appropriate therapy. Laboratory tests Since equipoise vs deca binds to all CD20-positive lymphocytes (both tumor and normal), during treatment equipoise vs decaom necessary at regular intervals carry out the control hemogram; if patients develop cytopenia, a study should be done more often. With the development of cytopenia is necessary to carry out the appropriate therapy.
Effects on ability to drive vehicles, machinery
Research equipoise vs decaa influence on the ability to drive a car or work not performed on automatic equipment. Based on the pharmacology equipoise vs decaa, reasons to suspect that the adverse effect of the drug on these kinds of no activity. When considering the possibility of the patient to perform activities that require high concentration and psychomotor speed reactions must be taken into account his clinical condition and the profile of adverse reactions equipoise vs decaa.
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Posted in Steroids | Tagged equipoise vs deca
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