The full dataset viewer is not available (click to read why). Only showing a preview of the rows.
The dataset generation failed
Error code: DatasetGenerationError
Exception: ArrowInvalid
Message: JSON parse error: Missing a closing quotation mark in string. in row 123
Traceback: Traceback (most recent call last):
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 153, in _generate_tables
df = pd.read_json(f, dtype_backend="pyarrow")
File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 815, in read_json
return json_reader.read()
File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1025, in read
obj = self._get_object_parser(self.data)
File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1051, in _get_object_parser
obj = FrameParser(json, **kwargs).parse()
File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1187, in parse
self._parse()
File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1403, in _parse
ujson_loads(json, precise_float=self.precise_float), dtype=None
ValueError: Trailing data
During handling of the above exception, another exception occurred:
Traceback (most recent call last):
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1997, in _prepare_split_single
for _, table in generator:
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 156, in _generate_tables
raise e
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 130, in _generate_tables
pa_table = paj.read_json(
File "pyarrow/_json.pyx", line 308, in pyarrow._json.read_json
File "pyarrow/error.pxi", line 154, in pyarrow.lib.pyarrow_internal_check_status
File "pyarrow/error.pxi", line 91, in pyarrow.lib.check_status
pyarrow.lib.ArrowInvalid: JSON parse error: Missing a closing quotation mark in string. in row 123
The above exception was the direct cause of the following exception:
Traceback (most recent call last):
File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1529, in compute_config_parquet_and_info_response
parquet_operations = convert_to_parquet(builder)
File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1154, in convert_to_parquet
builder.download_and_prepare(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1029, in download_and_prepare
self._download_and_prepare(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1124, in _download_and_prepare
self._prepare_split(split_generator, **prepare_split_kwargs)
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1884, in _prepare_split
for job_id, done, content in self._prepare_split_single(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 2040, in _prepare_split_single
raise DatasetGenerationError("An error occurred while generating the dataset") from e
datasets.exceptions.DatasetGenerationError: An error occurred while generating the datasetNeed help to make the dataset viewer work? Make sure to review how to configure the dataset viewer, and open a discussion for direct support.
pred_label
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float64 | wiki_prob
float64 | text
string | source
string |
|---|---|---|---|---|
__label__cc
| 0.710244
| 0.289756
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How many times have you asked someone for a few tips to help point you in the right direction? As medical school faculty, we have just such a source.Twelve Tips... is an easy-to-access and useful resource for medical school faculty, particularly faculty new to medical school teaching. It is available as a monthly feature in the journal Medical Teacher. Twelve Tips... provides a brief how-to focusing on topics familiar to basic science and clinical education. Each article is only three to four pages, providing a helpful introduction to the topic as well as references for further reading. It is a good starting place when faced with a problematic educational issue or when looking to enhance an educational experience or learning resource. These articles are presented as 12 tips to help you frame an issue, learn a new concept or point you to other resources.
Here is a sample of Twelve Tips... articles that have appeared in the past year:
Twelve Tips for...
Evaluating educational programs
Designing and implementing a learner-centered curriculum
Effective team-based learning
Introducing e-portfolios with undergraduate students
Presenting a clinical skills problem-solving exercise
Teaching diversity and embedding it in the medical curriculum
Authoring virtual cases
Successful e-tutoring using electronic portfolios.
Medical Teacher is available electronically to all MSU faculty through the MSU Library e-resources (http://er.lib.msu.edu/). The Twelve Tips... series was started in 2005, with contributors representing the efforts of talented educators from around the world.
The Primary Care Faculty Development Fellowship Program, run by OMERAD for over 30 years, has received funding for two more years from the U.S. Health Services and Resource Administration. The Fellowship brings together academic faculty from family medicine, internal medicine and pediatrics to provide them with the skills needed to be successful during an academic career and to assist them in the design, development and dissemination of a scholarly project.
Primary Care Research and Development Conference Each year fellows in the MSU Primary Care Faculty Development Fellowship Program design, develop, implement and evaluate a major research or curriculum project. We invite you to attend the poster and oral presentations of this years' fellowship class.
Fellows' Major ProjectPoster Reception
Radiology Atrium
Fellows' Major Project Oral Presentations and Graduation
Kellogg Center, Red Cedar Room
The oral presentations will be reviewed by two national leaders in medical education. A complete list of this years fellows' Major Project topics can be found at: www.omerad.msu.edu/fellowship.
If you are interested in attending, please RSVP by email.(There will be a conference registration fee of $35.00 for the Friday session.) For more information, contact William Anderson, [email protected] or Donna Mulder, [email protected] or 517-432-8722.
Drs. Brian Mavis, OMERAD Director, and Christopher Reznich, OMERAD Associate Professor, have chapters in the newly published text "An Introduction to Medical Teaching" (Springer, 2010). Dr. Mavis contributed a chapter on Assessing Student Performance, and Dr. Reznich a chapter on Designing a Course. The text was edited by Drs. William Jeffries and Kate Hugget of Creighton University.
It has already received one review on Amazon.com: "Who says you can't teach an old dog new tricks! This book is very helpful in developing new teaching skills for established educators. I would especially recommend it to my junior colleagues."
Screencasting and Podcasting with Camtasia on April 20, 4:00pm-6:00pm in A-211 East Fee. Learn how to use Camtasia Studio to quickly and easily create videos that meets the needs of today�s medical students. This hands-on seminar will be an introduction to creating lectures or other course content to be made available to students online (as a screencast) or on-the-go (Podcast). To register for these workshops, email us at [email protected]. Enrollment is limited to 18.
The CHM Outcomes Database and Report
The CHM Outcomes Report provides a statistical overview of CHM's students, alumni and the College's progress towards achieving its educational goals. The report is based on data from the CHM outcomes database, which comprises a comprehensive longitudinal data set describing CHM students beginning with their medical school application, through surveys and tracking data on their careers as physicians. The outcomes database contains largely complete information dating back to students matriculating approximately 20 years ago.
The Outcomes Report is designed to provide a readily assessable summary of key statistical information that can answer the majority of the questions that arise concerning our students, their academic performance, perspective on CHM's educational programs and careers after graduation. In addition, OMERAD's evaluation group is available to perform custom analyses using the outcomes database to answer questions not directly addressed in the Outcomes Report.
The information in the outcomes database and Report comes from a variety of sources both external to and from within the college. These include:
American Medical College Application Service (AMCAS) database
CHM admission files
The Association of American Medical Colleges (AAMC) matriculation questionnaire
CHM student academic performance records
US Medical Licensure Examination (USMLE) scores
National Residency Match Program (NRMP) results
AAMC graduate questionnaire
A series of three surveys developed by OMERAD:
Survey of residency directors of CHM graduates (with permission) during their first year of residency
Survey of graduates 2 years after graduation focusing mainly on their perceptions of the CHM educational program
Survey of graduates 6 and 10 years after graduation focusing mainly on their practices.
AAMC Graduate Medical Education Tracking System (graduate and post-graduate training information)
The American Medical Association Physician Masterfile (practice profile)
The Outcomes Report is organized into three major sections: Admissions/Matriculation, MD Educational Program and Post-Graduation. Where possible the report provides comparison data based on all US medical schools. The report is generally updated semi-annually at the end of each semester and published in January and June. Most individual tables are updated once a year, although updates of the AAMC Graduate Medical Education Tracking System and the American Medical Association Physician Masterfile are only obtained every few years.
Please contact John Radford at [email protected] or call 517-353-2037 Ext 221 if you would like to obtain a copy of the CHM Outcomes Report. If you are involved in a CHM educational program and need statistical information on CHM students that is not contained in the Outcomes Report, please contact David Solomon at [email protected] or call 517-353-2037 Ext 223.
Open Educational Resources (OERs)
Open Educational Resources (OER) are teaching, learning and research materials freely available in the public domain for use or repurposing. These materials include:
Learning objects (quizzes, crossword puzzles, flashcards, animations, etc.)
Audio and audiovisual lectures
Entire course content and open courseware
Collections of journal articles and institutional repositories
OERs in Medical Education
There are repositories of OERs for medical education. The two largest are MedEdPORTAL and HEAL.
www.mededportal.org
MedEdPORTAL is a free online peer-reviewed publication service provided by the Association of American Medical Colleges (AAMC) in partnership with the American Dental Education Association (ADEA). MedEdPORTAL was designed as a repository for medical and oral health teaching materials, assessment tools and faculty development resources. All copyright and patient privacy issues are addressed during the submission process, so users around the globe can download and utilize any and all of the published resources for educational purposes without legal infringements (authors retain their original copyrights and indicate how others may use them). While MedEdPORTAL's primary audiences include health educators and learners around the globe, it is open and available for free to the general public. Users can access quality, peer-reviewed teaching material and assessment tools in both the basic and clinical sciences.
MedEdPORTAL is being used by all 143 US and Canadian AAMC member medical schools and over 1,000 teaching hospitals, international schools, and other health education institutions in over 20 countries.
Publishing in MedEdPORTAL
If you have worked hard to create a great educational resource and are ready to share it, you may consider publishing your medical or health sciences content using MedEdPORTAL.
From its conception MedEdPORTAL was designed to serve as a prestigious publishing venue through which educators may disseminate their educational works. Structured like a traditional print-based journal, MedEdPORTAL:
Maintains an editor and an editorial board.
Follows a peer review policy that mirrors practices employed by established biomedical print journals.
Employs a rigorous peer review process based on accepted standards of scholarship using invited expert reviewers to conduct all reviews.
An educational resource successfully peer-reviewed and published through MedEdPORTAL is considered a publication and is comparable to a peer-reviewed research paper published through a reputable print-based journal. Authors who publish through MedEdPORTAL benefit from the AAMC's authority and credibility, and have access to an audience drawn from its broad membership. Publications in MedEdPORTAL are considered compelling scholarly contributions suitable for use to support promotion and tenure decisions. For more information regarding MedEdPORTAL and educational scholarship, review the MedEdPORTAL Educational Scholarship Guides.
http://www.healcentral.org/index.jsp
HEAL is the International Association of Medical Science Educators (IAMSE) digital library and is another useful digital repository that allows medical educators to discover, download, and re-use over 22,000 medical education resources. The IAMSE and the co-directors of the Health Education Assets Library (HEAL) have been working together to further the development of HEAL to become a dynamic, user-centered digital environment to allow medical educators to share and discuss teaching resources and methods. This is being accomplished through the incorporation of key characteristics of Web 2.0 technologies, including user reviews of resources and user tagging (searchable keywords) of resources.
What is the difference between the types of resources published in HEAL and MedEdPORTAL?
HEAL publishes images, video clips, animations, presentations and audio files that support healthcare education. These are typically objects that can be used in a variety of presentations across multiple disciplines. MedEdPORTAL typically publishes more complete, stand-alone resources such as tutorials, virtual patients, simulation cases, lab guides, videos, podcasts and assessment tools.
HEAL resources are "tagged" when added to the HEAL database, which allows users who search with those terms (tags) to easily find the resources authors submitted. HEAL features a "Top User Tags cloud" which shows the most widely used tags in the HEAL database. In addition to the tag cloud, the "Top 10 Resources"--those resources with the highest ratings--are displayed on the front page.
To submit an object to HEAL, go to the HEAL home page and click on Submitting to HEAL.
To find out more about B-CLR (free) consultation services to CHM faculty, please contact the B-CLR Manager Geraud Plantegenest at: [email protected].edu. You may also visit us on the web at http://omerad.msu.edu/bclr/index.php
CHM Mission Focuses on Health Care Needs and Workforce Diversity
While all US medical schools engage in teaching, biomedical research and health care delivery, the institutional missions of medical schools vary, with each placing different emphases on these activities. The Medical School Missions Management Tool (MSMMT) was developed by the Association of American Medical Colleges as a means of providing medical school leadership benchmarks for the core functions and outcomes of medical schools. The MSMMT is based on information derived from multiple sources, and summarizes outcomes over multiple years.
One of the organizing themes of the 2009 Medical School Missions Management Tool was graduating a workforce that will address national health care priorities. Based on self-report data from CHM graduates of 1994 through 1998, CHM placed above the 50th percentile in three of the four indicators reported: primary care, in-state practice and practice in rural areas. These data reaffirm our historic commitment to primary care and serving the people.
The 2009 missions management tool also compared CHM to other medical schools with regards to preparing a diverse physician workforce. Four indicators were reported: two related to the diversity of CHM graduates and two related to the diversity of CHM faculty. The data were aggregated from 2002 through 2007, and show that CHM was above the 50th percentile on all four measures. These data provide independent evidence of our continuing commitment to enhancing the diversity of CHM, as well as our relative success in comparison to other US medical schools.
Do you need to travel somewhere to meet with someone, or to teach something, or to attend a course yourself? Do you have time to do this? Do you have the money to do this? If not, consider videoconferencing instead.
Videoconferencing allows people in two or more locations to see and talk with each other in real time, using two-way video and audio technology. Yes, the technology to do this can be expensive, but on the other hand, there is technology you may already have in your office or house that will let you videoconference from your desktop. All it takes at a minimum is:
a computer
a modern web browser (the latest version of Internet Explorer, Firefox, Safari, etc.)
a microphone (usually built in to computers) and
web videoconferencing software that MSU employees can use for free
MSU has chosen Adobe's Acrobat Connect as the desktop videoconferencing solution for all of campus. Acrobat Connect can be used to conduct face-to-face meetings, present lectures, give case presentations, give oral examinations, consult with colleagues, and present research conferences. In an Acrobat Connect meeting you can give a slide presentation, share applications and documents for group review and editing, take online polls, chat, and share whiteboards for brainstorming.
If you want to use Acrobat Connect to its full potential, you will need the specifications listed above plus a high speed internet connection and a web camera.
In order to manage and create new meetings you need to set up a Connect account through MSU Academic Technology Services (http://ats.msu.edu/organization/computing/instructional-systems/). Anyone on the web can participate in a Connect meeting if they are given the URL for that meeting. And since meeting rooms are persistent, you can use the meeting URL any time you need to meet. Meetings can also be recorded and made available to anyone who could not participate in the meeting.
OMERAD provides seminars on using Acrobat Connect. Contact John Williamson at [email protected] for information.
New publications by OMERAD faculty:
An Introduction to Medical Teaching
Chapters Authors: Mavis, B,
Reznich CB. Springer, 2010
See more info.
Meets 1st Wednesday of each month in room A216 East Fee Hall from 1:30pm-3:00pm
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Game Review: Half-Life 2
April 13, 2010 / BlueInkAlchemist / 6 Comments
In light of the recent March Mayhem throwdown over at the Escapist, I thought it’d be an interesting idea to pick up the Orange Box and see how well the various games within have aged. Since Valve wouldn’t exist without the ground-breaking awesomeness of Half-Life, the place to begin seemed obvious: Half-Life 2.
Gordon Freeman, unlikely hero of the Black Mesa Incident that introduced Earth to the inter-dimensional border world of Xen. After defeating that planet’s overlord, Freeman disappeared and the way was paved for an alien conglomerate known as the Combine to conquer the planet in the Seven Hour War. That was ten years ago, and now Freeman’s returned from parts unknown because, as the mysterious and somewhat disturbing G-Man informs him (and us), “The right man. In the wrong place. Can make all the diff-erence. In the world.”
The Source Engine that drives the game debuted almost 6 years ago, but the graphics and gameplay of Half-Life 2 still feel fresh and immersive. Like the original game, everything happens from Gordon’s perspective and there are no breaks from the in-game action to pre-rendered cutscenes. This lends a sense of realism to the game and doesn’t interrupt the flow of the story. The game’s opening, with Gordon unarmed and unprotected in an environment that is at once familiar due to the architecture and alien because of things like Dr. Breen’s huge video screens, citizens discussing lost memories and missing loved ones and Civil Protection is poised to draw the player into the experience right from the start without needing to put a gun in our hand right from the off. Suddenly, in a game that’s billed as a first-person shooter, a guy with a shock baton is actually an intimidating threat, and when you do lay your hands on a firearm, it’s pretty satisfying to start shooting them up.
“Pick up that can.”
The game’s Havoc Physics make for interesting puzzles, harrowing platforming and moments of hilarity when an explosion sends soldiers or zombies flying through the air. You collect a decent selection of weapons over the course of the game and you’re not forced to pick any one or two of them to use at a time. It can be hard to find ammo for things like the crossbow, but pulse rifle rounds are plentiful in the later bits of the game provided you’re not trapped in a basement surrounded by headcrabs.
While we’re on the subject, Half-Life 2 has three elements that really make it a stand-out experience in the realm of shooters. The first is the ability to build atmosphere. From musical stings to lighting effects, the mood of the game can slip effortlessly from pulse-pounding run-and-gun battles to spine-tingling survival horror sequences. Ravenholm in particular creates a feeling not unlike that of System Shock 2 or Eternal Darkness, with shambling grotesqueries moaning their laments as they claw for your brains. It’s especially harrowing if you play through it using the second stand-out element: the gravity gun.
“Ludicrous Gibs” comes to mind.
The idea behind the gravity gun is simple: you can use it to pick up and/or toss items around you in the world. Grab power-ups from behind fences, pick up boxes and move them around to solve puzzles, and hurl objects like propane tanks, concrete blocks and saw blades (my personal favorite) at enemies. If you find yourself low on ammunition for your weapon of choice, or if you’re locked in an area with headcrabs and zombies where ammo is likely to be scarce, switching to the gravity gun and just using whatever’s at hand to keep them from chewing on your PhD-scale brainmeats not only conserves precious ammunition but presents a challenge that can be difficult to find in first-person shooters.
The third and final element that, to me, makes Half-Life 2 great can be summed up thusly:
Alyx.
Women in games can be reduced to caricatures or over-sexualized playthings, even when they’re main characters (*cough*BAYONETTA*cough*). Female sidekicks often have it worse, as most games will see them being whiny unhelpful escort objectives, support characters that fall in love with or betray the protagonist for some overly contrived reason, or all of the above. Sometimes, if they’re lucky, the lady of the game will avoid these problems but will instead be so thick-skinned and unapproachable that they might as well be men.
Alyx Vance takes all of those expectations and kicks them square out the window right into a nest of headcrabs. She’s smart, capable and tough, but she’s also funny, emotional and affectionate. It takes more than a particular kind of particle shading to make a character feel real in a video game, and Alyx is one of the most realistic characters I’ve encountered, especially in a shooter. And it doesn’t hurt that she’s pretty easy on the eyes, as well. Finally, she introduces us to D0G, but I’ll save my thoughts on the big guy for another review. I’ve got a couple more to do, after all.
Bottom Line: Half-Life 2 is one of the best shooters I’ve ever played. Despite its age, it feels fresh and fun, and leaves us wanting more. Steam users can get their hands on it pretty easily, but X-Box owners who don’t already have the Orange Box should consider finding that compilation if they haven’t already. This title justifies the cost of the entire product.
But hey, if you don’t believe me and want to see how the other products fare, just stay tuned…
Orange Box Reviews: 20% complete.
Gaming, Reviews
GamingReviewsshooterValve
Diving Right In
Girls in Gaming
I don’t know man, it’s still not as good as Halo.
Sorry, couldn’t resist 🙂
Splooge
Half-Life > Halo
*Commence flamewar, 3, 2, 1…*
No, but really, nice review so far.
I’m guessing you’ve played HL1 before; do you still think it holds up even today?
I do! It’s still kind of fun to romp around Black Mesa and fight aliens, marines, and black ops. Oh yeah, can’t forget Opfor and Blue Shift!!
halflife > halo
it is a lot better. Halo istnt that great
Girls in Gaming :Blue Ink Alchemy
Game Review: Half-Life 2 Episode 1 :Blue Ink Alchemy
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"Hey Guys-
I received both books yesterday and I am up to the fourth chapter and I am LOVING IT. Bud, it is terrific and can't wait to get back to reading it. More later.
Love to all, Phyl"
-Phyllis Smith, Actress
Known as the character Phyllis Lapin on the Emmy Award winning show THE OFFICE
Is the "voice" for the character "Sadness" in the Disney Pixar film, Inside Out.
"The Mercer Brothers talent, energy, warmth, and humor entertained Howard and me for many years at the Palm Springs Follies. Howard was proud and honored to be on the same boards with these multi-talented guys. Now, Bud has written a delicious romp through all his and his brother Jim’s golden years of vaudeville and Hollywood that I personally didn’t want to end.
Thank you Bud.”
-Mrs. Howard (Judy) Keel
"Bud Mercer's book is a delight for everyone who has enjoyed stage shows, movies and television in the last seventy five years. He gives readers behind-the-scenes information as to how show business operates and shares unique vignettes of the stars that have provided us with so much entertainment through the years. Bud Mercer is a real trooper and his joy in performing is contagious."
-Frances Davidson, Producer,
Davidson Films, Inc.
"The Mercer Brothers personify show business…particularly the golden era that was known as Vaudeville. What Bud and Jim Mercer brought to Follies audiences for eleven seasons other than extraordinary entertainment - was nothing short of a history lesson. Sadly, their act may well be the last of its kind…we are all the richer for
having witnessed it.”
-Riff Markowitz, Impresario of the
Fabulous Palm Springs Follies
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The Official General Hospital Fan Club
THE GH FAN CLUB
GH Fan Club Sign Up
GHFC Mailing List
THE GH FAN CLUB WEEKEND
GHFCW 2020 Update/Date Change
GHFCW 2020
GH Fan Club Weekend 2020 Tickets
GHFCW Reservation/Hotel Information
GHFCW FREQUENTLY ASKED QUESTIONS
WANT TO LEARN MORE ABOUT THE GHFCW?
GH STORE
GH ACTOR FAN CLUBS & WEBSITES
GH ACTOR CHARITIES
GH Actor Birthdays & Twitter Handles’
CONTACTING THE GH STUDIO/ACTORS
E-mail the GH Fan Club
Contact the GH Studios/Actors
PETER FRANKLIN HANSEN 1921 – 2017
Debbie Morris, President April 12, 2017 April 26, 2017 Comments Off on PETER FRANKLIN HANSEN 1921 – 2017
December 5, 1921 – April 9, 2017 Peter was born December 5, 1921, in Oakland, California, to Sidney Henry Hansen and Lena Gertrude Young.
Peter was raised in Detroit, Michigan and graduated from Lincoln High School where he met Florence (Betty) Elizabeth Moe. He attended the University of Michigan then enlisted in the U.S. Marine Corps. Peter and Betty married on July 7, 1943. Peter flew combat in the South Pacific. He followed his dream of acting to the Pasadena Playhouse with Betty and daughter Kristen Elizabeth. He was signed by Paramount Studios, and featured in “Branded” (1950), with Alan Ladd, “When Worlds Collide” (1951) and “The Savage” (1952), with Charlton Heston. Peter acted on stage on Broadway, in Los Angeles and San Francisco. His many television appearances included Sea Hunt, Jim Bowie, Science Fiction Theatre, Perry Mason, The Lone Ranger, and Matinee Theatre. He was spokesman for Plymouth automobiles on Lawrence Welk, Steve Allen and Gary Moore variety shows. In 1961, he was news anchorman at KCOP-TV. His most memorable role was as Lee Baldwin on ABC’s enduring daytime drama, “General Hospital,” from 1965 to 2001, earning an Emmy in 1979 for Outstanding Supporting Actor. In 1997, he helped launch “Port Charles.”
He loved flying, owning his own Cessna for decades, spent many vacations in the Sierra Nevada high country. He led a devoted spiritual life at St. Nicholas of Myra Episcopal Church, Encino. Peter was husband to Betty for 50 years until her death in 1993. He shared 24 years then as companion to Barbara Wenzel. He is survived by son, Rev. Canon Peter Falconer Hansen (Giti), daughter, Gretchen Hansen Chartier (Dr. Robert); grandchildren Allison Severn, Erik Johnson (Aminy) and Jamal Hansen; and great-grandchildren.
A memorial requiem will follow at a later date. Peaceful Reflections, 26752 Oak Avenue, Ste A, Santa Clarita, CA 91351, are handling the funeral arrangements.
Published in the Los Angeles Times from Apr. 11 to Apr. 12, 2017
NEWS #GH, #latimes, #peterhansen
» Cancellation of GHFCW 2020
» January Birthdays
» September Birthdays!
» August Birthdays!
» Comings and Goings & the Rumor Mill!
Happy Birthday Kirsten Storms!
GHFCW 2017, with Line-Up, Glendale, CA.
GH FAN CLUB WEEKEND TICKETS
Click here to download the order form for the Kickoff Welcome Reception – Thursday, July 30
Click here to download the order form for the Main Cast Luncheon – Saturday, August 1
Click here to download the order form for Platinum tickets to the Main Cast Luncheon – Saturday, August 1 – SOLD OUT
Please read your order form carefully. We cannot process incomplete orders or orders with incorrect payment.
Join the GH Fan Club
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Copyright Restriction
Copyright © 2017 Official GH Fan Club. No information from this site may be reprinted, duplicated, or otherwise distributed without permission from the GH Fan Club
GH IS A PRODUCTION OF:
SITE DESIGN; This site is created and maintained and this template customized by Earthmom Designs
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About Trap Shooting
A practice or competition event will consist of shooting two 25 target rounds for a total of 50 targets from the 16-yard station. Up to five athletes (squad) will occupy the stations on a trap field. Station one is assigned the “squad leader”.
Trap Field
The trap field is the area of a shooting range where trap shooting occurs. Each field contains shooting stations (typically concrete walkways with yardage markers) and a trap house.
The trap house is the structure in front of the stations from which the clay targets are launched. Only facility personnel shall enter and maintain the trap house. A cone or flag will be displayed when the trap house requires maintenance and shooters are required to exit their shooting station and make firearms safe until the trap house maintenance is completed and the cone or flag is removed
Ammunition specifications must meet the use requirements of the shooting range.
Typical ammunition used for trap shooting:
12 1 oz. or 1-1/8 oz. #7.5 or #8
20 7/8 oz. #8
Five shots are taken at each of the five stations. After the first five shots are completed by the entire squad, each shooter will move to a new station by:
Verifying the gun is unloaded.
With the chamber open and the shotgun pointed in a safe direction, rotate in a clockwise manner to the next station.
Station one will move to station two, two to three, three to four, four to five, and five to one.
Station five will rotate to their right moving away from the station four shooter who is moving to station five and continue to walk behind the other shooters to station one.
Await the “START” command from the scorekeeper.
The squad leader is the first to shoot in each round.
Repeat process until all shooters have each shot 25 targets.
No shooter will move to the next station until the last target in a round is completed.
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Company Approach Portfolio
Bio Press Contact
Cymbal Development is a design-driven development and construction company that creates and enhances communities. We are sensitive to our environments and engage in strategically important and responsible projects. Our firm was formed with the intent of developing and constructing aesthetically significant neighborhoods.
We focus on value creation, on transformational projects, and on projects that create the highest possible yields for our investors. We typically undertake projects that have a complex legal, financial, entitlement, or construction component.
Our company excels in developing urban mixed-use properties in underutilized neighborhoods. Our development projects typically spur additional, thoughtful development and are a catalyst to further quality-of-life improvements.
Above all, our projects must be thoughtful and exciting. They must make a significant, positive impact on the community, and be economically compelling.
We are structured as a creative, entrepreneurial, and intellectually curious company committed to leaving a positive mark on the places and people that we focus on.
Developer Point of View
Urban infill developer
Design-driven
Creator of communities
Works with internationally renowned architects and designers
Opportunistic real estate investor
Achieves spectacular yields for its investors
Expert in complex construction and real estate development
Q&A With Asi Cymbal
Q: How has your background given you a competitive edge as a developer?
A: I have great sensitivity for my environment, and I also have passion for architecture and design. That passion is critical in order to contribute in a positive way as a real estate developer. It took me a long time to realize this, but good design enhances quality of life.
As a businessman, builder, attorney, and restauranteur, I can draw from a varied skill set to envision a cohesive community, navigate the myriad political, financial, legal, and logistical obstacles in its creation, build it, and then curate the community in a manner that gives it life and soul.
Q: Why do you focus on urban projects? What is your process for vetting deals?
A: I identify with urban. I grew up in New York City and spent most of my life there. I also spent considerable time in Los Angeles, Tel Aviv, and now Miami. These are all cosmopolitan, urban cities. There is an intellectual and sophisticated dynamic and curiosity to these cities, and a nuance that I am in tune with and that I believe gives us a competitive advantage.
The deals that we pursue need to be exciting, make a significant positive impact on the community, and must also produce the greatest possible yields for our investors. We typically focus on value creation, on deals that transform communities, and that are economically compelling. We are very precise and selective in the deals that we undertake. We typically review hundreds of deals before closing on one. We are looking for home runs.
Q: Design is an important aspect to your developments. Why?
A: I have worked with the best architects and designers in the world and they have taught me about good design and the impact that it makes. Good design enhances lives and inspires communities.
A real estate developer has a moral obligation to leave its environment better than it found it. It doesn’t take more money to produce a beautiful project. It merely requires sensitivity and thoughtfulness.
I have no interest in building an uninspiring box and squeezing money out of it. But if you build beautiful buildings and communities, you will maximize a project’s value on all levels.
Q: How have your other ventures helped inform your development strategy?
A: As a restauranteur, I have seen the impact that food and beverage businesses have on communities and development projects. Restaurants and bars serve as social gathering places. They give color and soul to neighborhoods. These food and beverage businesses are an important ingredient to the creation of communities. We use them as our starting point. From there we will curate the retail, office, and residential uses to complement the mixed-use projects that we create.
As an attorney, I am not afraid to take on projects that have ‘hair’ on them, projects that involve complex legal or construction challenges, or projects that everyone else will stay away from. We like projects that no one else wants or that others are scared of. We find them to be intellectually stimulating and meaningful. Those projects maximize our yields and are the cornerstone of our investment strategy.
Q: What does it mean to be an innovative developer?
A: To be innovative is to create something new or compelling in a way or place that no one else thought of before. Much of the time, being innovative requires taking risks.
An innovative developer is a calculated risk-taker, is creative, and has deep sensitivity.
Sometimes this involves creating environments that no one thought was needed or wanted, or that are not immediately supported by empirical data.
Q: How do you consistently deliver financial success to your investors?
A: It takes a lot of responsibility and trust to handle other people’s money. I do not take that responsibility lightly.
There is nothing more important than to insure great yields to our investors. That is the number one priority in our company and it guides all aspects of our investment strategy.
We strive to return a minimum of 30% in annual yields to our investors and have been fortunate enough to exceed those numbers to date.
Our future plans are ambitious. We would like to develop $4 billion in projects within this real estate cycle and be the premier multifamily developer in South Florida. The only way to do that is to have a strong track record of producing high yields for our investors, and we are extraordinarily motivated to do so.
Our deals are structured in order to protect our investors and their principal investment. The only way that our company can reap profits on our investments is if our investors first see tremendous financial rewards. Our investors must get their principal back plus significant preferred returns before we see any upside on the deal.
We are very cautious on the investments that we make, pay close attention to our costs and basis in the deal, and are highly selective in the deals that we undertake.
Our goal is for each and every deal to be a financial home run.
© 2023 CymbalDevelopment.com | Company | Approach | Portfolio | Bio | Press | Contact | Admin
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Opening the doors and letting society in
Posted by Harry Brady | Aug 24, 2019 | Articles, Season 2019-2020 | 0 |
Football opens its doors and society walks in. Families and loners, philanderers and fools, if they exist in society, the attend the football. This is not some earth shattering comment. This is plainly obvious. Football opens the door and every aspect of society attends, for good and bad. That basic undeniable and obvious position is why the knee jerk reaction of politicians and social commentators to criticise the behaviour of the ‘dirty down market’ football fans when something unpleasant happens is so reprehensible.
But just because football is opening its doors to society, to all of society, good and bad, doesn’t mean that football can abdicate its responsibilities for dealing with illicit behaviour. Just last week I had to not only endure the poor football on the park at the Celtic v Dunfermline game, but I had to sit through nearly two hours of the vilest songs and chants aimed at me and my fellow Celtic supporters. A level of disgusting hate and association with the vilest acts, simply because I, and the people around me support a football team with its roots in the Irish Catholic community. We all want to maintain that vibrant, passionate atmosphere that football, almost uniquely, generates that is no reason to accept the behaviour of those who overstep and move from edgy to unacceptable, abusive, racist and sectarian.
We have seen in recent times with the advent of social media that anonymity can wash away the acceptable veneer of social norms and expose us to the uncomfortable fact that there are lots of unpleasant people out there, who when stripped of having to face up to their friends and neighbours, will exhibit behaviour and opinions that most of us find abhorrent. It is the anonymity of crowds that allows that illicit behaviour to exhibit itself at some football grounds, but in the same way that social media firms like Facebook and Twitter cannot continue to be allowed to let people post threats, abuse and hatred by saying it’s not their responsibility, so football clubs have to take more steps to deal with the behaviour of those who follow their teams. Equally, society cannot neatly package up these problems and leave them solely at the door of football. If, as it does, football has a problem with coked up supporters who think that they are invincible and have the right to say and do whatever they please whenever they please, then so does society.
And so, in 2019, finally a football authority has taken steps against Rangers football club and the sectarian and racist chants of their supporters. This has being something that has been going on for a century, and indeed was actively encouraged for most of that time by the club. In recent years, the charlatans who resurrected and created The Phoenix Club pandered to the bottom line and the knuckle-draggers, and chased the orange pound to take a big hefty chunk of it and put it in their own pockets. The football authorities in Scotland knew this and did nothing. But the orange pound and the knuckle-draggers only exist at Rangers because they exist in society, and they only exist in society because Scottish civil society has allowed that culture to breed and fester and live. Like a child being taught one set of morals at school and another set in the home, how can we expect some of the Ranger supporter to understand that anti-Catholic, racist hate is not acceptable in a football ground, and yet anti-Catholic orange walks are celebrated and allowed throughout Scotland?
How can we expect Ranger supporters travelling across from the North of Ireland to understand that anti-Catholic songs of hate are unacceptable in modern 21st century Britain when anti-Catholic bonfires and anti-Catholic marches are an accepted part of social discourse? How can we expect anyone immersed in generations of anti-Catholic hate to self-police when BBC NI will broadcast a day of “celebrating protestant culture” on 12th July?
In the 21st Century, adults shouldn’t need to be told what is and isn’t considered acceptable to be said and sung in a public place. There shouldn’t even be a debate when someone says Fenian B and Orange B are just not on but patently education and punishment is required. To facilitate the education of the arseholes, football clubs can and should do more to make it clear that certain types of behaviour are just unacceptable in a public environment. But if we want these illicit and repugnant songs and chants of hate to end, then all of society needs to deal with it.
PreviousUnconscious Bias
NextCeltic Sign a Right Back
P/C 13th & 14th Feb – Goals for Greens Special
Celtic Underground No272 – Post Cup Semi Barney
DEBUT DAYS – MARC REIPER
Does Celtic Need Rangers?
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Metra 125 GM EMD F40PH diesel-electric locomotive "DuPage County" with its outbound scoot stopped at the station (distant right). A Wisconsin Central mixed freight train waits on the siding (left).
METX 125, METX, GM EMD F40PH, Metra locomotives, Locomotives, photographed on 7 October 1998 at O'Hare Transfer station by Harold A. Driscoll using a Sony Mavica MVC-FD7 digital camera [railfan/1998/10/98a07r06.jpg] NEW 25 January 2000
Metra 125 was built between 1977 and 1980. It is rated at 3,200 horsepower.
Metra numbers 100-127 were built by General Motors Electromotive Division for EMD order number 766062 in 1977, EMD model F40PH. Metra assigned them to the Rock Island, Milwaukee, and miscelaneous} lines. [Courtesy of Metra Railfan Page]
METX 125, model F40PH, built November 1977, builder number 766062-26, named "Du Page County," assigned to Metra/North Central Service. [courtesy of Metra Locomotive Information, by Mike Azen, February 2000]
METX 125 is a 3,200 horsepower model F40PH-2, built in 1977 by General Motors Electro Motive Division. [courtesy of The Official Locomotive Rosters & News, James W. Kerr, 2000 edition, ISBN 0-919295-32-0, August 1999]
Equipment characteristics of METX 125: AAR car type D215 (locomotive), plate type E, external dimensions (length 56' 2", width 10' 8", height 15' 8"). [courtesy of BNSF Equiptment Characteristics, October 1999]
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Thriven and thronovel She Becomes Glamorous After The Engagement Annulment novel – Chapter 466 – Evidence! x-ray unaccountable reading-p1
top strong cultivator as a teacher manga
Chapter 466 – Evidence! well-made crack
She authorized her diagnosis and autopsy review and handed the crooks to the health care worker. Then, she viewed the health professional and reported, “The root cause of dying is decided, let us cremate the corpse now.”
In addition, Captain Ford coming from the distinctive department… had an honorable standing and was admired by every person. At the very thought of this, Elaine’s face switched slightly crimson as she grew to be fired up.
Nora pressed the door open up and came into.
It was actually too hard to rest to him.
The health professional was stunned. “So rapidly?”
nurturing the hero to avoid death ch 1
Following she was removed, Nora decided to go upstairs very first.
Nora left behind your home and called Joel. Joel already understood with regards to the scenario if the authorities arrived to arrest him. He said, “I’m getting my legal representative through. I’ll probably get there using them.”
She agreed upon her medical diagnosis and autopsy review and given them to the health professional. Then, she investigated the health professional and stated, “The source of dying has been established, let us cremate the corpse now.”
She reduced her go and achieved Pete’s stern but really serious experience.
Nora coaxed her with consideration. Her speech was very delicate. Even though it was serious, it was actually very soothing. After saying that, she investigated Cherry and found the fact that minor fellow’s big eyes were definitely darting all around. She pouted and after that silently believed to Nora, “Mommy, you’re being untruthful.”
Moreover, Captain Ford in the specific department… acquired an honorable rank and was appreciated by everyone. At the very thought of this, Elaine’s confront changed a little bit red as she grew to be fired up.
This fellow was really precious!
She closed her diagnosis and autopsy article and handed them to the health care worker. Then, she checked out the nurse and reported, “The reason for dying has been determined, let us cremate the corpse now.”
Nora pressed the entranceway open and inserted.
Nora and Joel had been banned to discover Tanya ahead of the event was manufactured. Exactly the legal professionals were definitely capable to go over these matters.
Soon after she was removed, Nora gone upstairs primary.
Nonetheless, Nora explained truly, “Pete, Mommy isn’t coaxing you. I am informing the facts. Cherry possesses a abrasive personality and a massive coronary heart. I’m anxious about having her look after individuals. However, if it is Pete, Mommy will be alleviated!”
Nora and Joel were not allowed to discover Tanya before the scenario was highly processed. Only lawyers have been permitted to explore these concerns.
The registered nurse was surprised. “Special office?”
Nora stated, “You people have a good time listed here. I’ll obtain the nanny to watch more than all of you. You all have to stay at home obediently these days, all right?”
It had been the weekend these days, therefore, the youngsters did not visit institution. These folks were taking part in inside and did actually already know the noises downstairs. Therefore, when Nora moved into, she spotted Mia anxiously sporting her boots and shoes. She asked in a small voice, “Why was my mommy arrested?”
Mia: “Okay!”
Mia really was deceived by her confidence. She nodded. “Okay.”
She minimized her top of your head and fulfilled Pete’s stern but really serious experience.
Nora coaxed her patiently. Her tone of voice was very soft. Even though it was serious, it was subsequently very mild. Soon after stating that, she investigated Cherry and noticed the fact that little fellow’s significant eyes ended up darting all around. She pouted and next silently said to Nora, “Mommy, you’re being untruthful.”
Just after over half sixty minutes, the lawyer or attorney walked out with a frown. “The make a difference has become clarified! They do indeed contain the proof to lower back Ms. Turner’s arrest! Hillary’s fatality was a result of the poisons in her body system. Through the time she was detained, only Neglect Tanya had seen her! She administered something in Hillary’s infusion prescription drug. This were documented by the security cams. We are for a wonderful disadvantage right now!”
It had been too difficult to lay to him.
The fresh registered nurse failed to be aware of them, so she requested hesitantly, “What’s that?” Elaine said, “It’s a section on top of the regular cops support. Should they dominate the situation, most of us have to listen to them… Ignore it. You won’t comprehend regardless if I show you this. At any rate, after this instance is successfully closed, I’ll have plenty of encounter built up to try to get a job inside the unique division.” If she could enroll in the specific section, it becomes an respect for her!
Mia was really misled by her trust. She nodded. “Okay.”
The little health professional did not be aware of them, so she asked hesitantly, “What’s that?” Elaine said, “It’s a office across the normal police officers assistance. Should they take control the situation, every one of us have to listen for them… Ignore it. You won’t fully understand even when I let you know this. Anyways, after that situation is successfully shut, I’ll have adequate expertise amassed to get a position in the unique section.” If she could be a part of the special division, it becomes an respect for her!
Gallowsnovel She Becomes Glamorous After The Engagement Annulment – Chapter 469 – A Turn of Events!! road bore read-p2
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UXENG.net
Musings of a UX Engineer, Designer, Developer and Entrepreneur
UX Eng – Research Picker
Accessibility, UX
A strategy for building custom accessible widgets
Written by The UX Engineer on September 16th, 2016 March 14th, 2017 .
As a UX Designer does it matter if you create custom styled form widgets for your web sites/apps? What are the risks and implications of creating these?
We’ve now reached a point where the online user experience has become a key differentiating factor between very similar online products and services, in a very saturated marketplace. With each new product attempting to outshine its competitors, many UX/UI Designers are resorting to creating interactive widgets that go beyond the usual HTML form controls.
Custom widgets like date pickers, auto-complete option/selection boxes, tree widgets, toggle switches, can be powerful in helping users navigate complex data sets and complete multi-stepped tasks. However when they get built, developers end up writing these components from scratch because they look inherently different. If the underlying semantics in the mark-up aren’t correctly applied, the content can immediately become inaccessible, to those using assistive technology (AT).
A simple example: the funky drop-down
Lets say you have a funky looking drop-down, but it’s built with mark-up that has no semantic value i.e. a bunch of divs and spans just to make it match the design; no screen reader will know that it is a drop-down like component and won’t announce it as one, or that the user even has the ability to make a selection.
I’m not suggesting to avoid creating new interactive widgets, however I do recommend that in instances where it is possible, reuse any native HTML widgets – and leverage the power of CSS and then JavaScript to achieve your goal. So if your funky new widget smells and behaves like a drop-down, it’s probably best the underlying widget is a drop down – this way when it’s being built the developer doesn’t have to spend lots of time having to build detailed controls that expose the current states and properties to assistive technologies like screen readers. In a nutshell, if you can use a native widget but don’t, you’re simple redoing a lot of work you already could have for free – not to mention adding a lot of mark-up and script overhead to your page, reducing performance.
The following example, shows a heavily styled drop-down that doesn’t look like its native variant, but is only utilising CSS to alter the look and feel whilst still keeping the underlying semantics the same.
See the Pen Funky yet accessible drop down by uxeng (@uxeng) on CodePen.
You may have also noticed if you accessed the code example provided with a screen reader, the user never has the ability to focus on the span element containing the down chevron; I’ve purposely placed aria-hidden=”true” on this element, as it’s purely decorative.
It’s these touches which create better accessible user experiences, as it allows the user to focus on important content without other clutter.
A strategy for building custom widgets
Building custom widget components, even something as seemingly simple as a modal dialog box with a couple of Yes / No buttons, requires a fair amount of thought to ensure they are accessible and navigable in a sound and logical way within the browser by a screen reader.
This short checklist, should help you build components that are robust and carefully consider user accessibility,
1 – Logical flow
Are the sub-components of the widget ordered in a logical semantic manner? Keep items organised in a logical manner, so that they inherently make sense if read in a linearised format.
In the dialog box example, the DOM order should be as follows: 1 – Dialog Title, 2 – Content, 3 – OK button, 4 – Cancel button, 5 – Close dialog button. Even though the close dialog button is at the top of the dialog, it logically should be the last element in the dialog box – this is especially pertinent for screen reader users.
2 – Manage keyboard focus and access
Ensure interactive component elements if needed are tabbable (and there aren’t any keyboard traps). Carrying on with the dialog example – when the dialog is overlayed onto the page – content behind the dialog should not be able to receive keyboard focus. Screen readers should not be able to navigate to this now obscured/hidden content either.
In this instance to achieve this effect, when the dialog appears three actions will need to be undertaken.
Focus is programatically shifted from the invoking element (the button pressed to raise the dialog) to the dialog’s container element – this container should have tabindex=”-1″ to allow this.
All the focusable elements outside of the dialog need to have a tabindex=”-1″ set, so that they can no longer receive focus.
All content outside of the dialog should be marked as aria-hidden=”true”, this is simply achieved by placing this attribute on a container which wraps the remaining page content (obviously not one which includes the open dialog box).Simply reverse these steps when closing the dialog.
The dialog example didn’t have to capture keypresses, so had a relatively simple script – for example if you’re building a tab control, you’ll need to make sure that you utilise JavaScript to allow “left/right” cursors keys to switch along tabs, this is similar to the default behaviour between radio buttons in a single group.
3 – Maintain widget state information with WAI-ARIA
The WAI-ARIA spec outlines a raft of widget roles like progress bars, sliders, and trees; which is great because it means you can build complex widgets and ensure they are accessible. However, widgets like progress bars need to be updated by JavaScript – and the associated aria-attributes also need to be updated accordingly to highlight changes back to the assistive technology. It’s not particularly complicated all you’re doing is adding the correct context and semantics to the arbitrary elements, so they’re exposed to the accessibility API.
4 – Remove unnecessary elements for assistive technology users
As we discussed earlier with the funky drop-down example, elements that are there for decoration (those stray divs and spans used to anchor sneaky before and after pseduo selectors), but serve no semantic or functional purpose should be removed from being picked up by assistive technology. This can be done by simply adding aria-hidden=”true” to the offending elements. This simply reduces confusion and ambiguity around non-standard widgets when a user is utilising assistive technology.
But I use a widget framework…
It’s easy to assume that if you’re using a popular framework like Bootstrap 3, which is loaded with custom widgetry, all of this is taken care of; in some instances the widgets they have built are constructed with accessibility in mind, in others a little less so. Other frameworks like Zurb’s Foundation 6, claim to be built from the ground up to be accessible – i’ve been tinkering with Foundation 6 and found that they do generally follow good semantic markup practices and have infused accessibility from the outset, but a quick play with a screen reader on the Foundation 6: kitchen sink page (where they have all their widgets present) unfortunately led me to find a few clunkers.
So the takeaway here is that even the widely used open source web frameworks aren’t a silver bullet, and need some further finessing to make the accessible experience as good as it needs to be.
But this isn’t my problem…
If you’re a UXer, you may be thinking this is all too technical for me, which is why it’s imperative that UXers work closely with the development team from the outset; and also start becoming more comfortable with understanding code and the technical aspects of the product they’re designing. After all we’re architecting digital products, and we should know the materials we’re using alongside it’s limitations and capabilities.
Dark UX Patterns: Whatsapp & Privacy
Job stories, and the value proposition
Using UX psychology to build healthy work habits and reduce anxiety February 14, 2021
Five ways the corona lockdown impacts UX April 27, 2020
What can we do to humanise our “user experiences”? February 11, 2020
3 Recent dark pattern implementations you have probably missed January 27, 2020
Silicon Valley ‘Tethics’ in the real world January 22, 2020
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Wild Games Announces The Launch Of IOS Game Gravinaytor
Ontario’s Wild Games Studio and Boston-based Alnoor Games have released Gravinaytor, an iOS adaption of the very popular flash-based game of the same title. Gravinaytor features 5 new levels in the iOS version, along with new tutorials, updated in-game navigation and beat the clock modes. Read the rest of this entry »
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posted in Everyone 10+, National News, New Releases, Platform By: Tami | Print This Post
Icarus Named To September Top Indie Games By Game Tunnel
Congratulations to BC indie developer Justin Scott, whose 2D PC side-scrolling game Icarus has been recognized as one of the top indie games on the market by American review site Game Tunnel. A graduate of Simon Fraser University, Justin has worked at PartnerPedia’s Vancouver office, and currently works for Telus as a Developer Analyst. Read the rest of this entry »
posted in Everyone, New Releases, Platform By: Tami | Print This Post
Troll Blaster Available on iTunes
I told first told you about Troll Blaster early in September, but somehow missed the game’s release. I’m making up for that now with an (only a little late) notice that Montreal-based mobile software firm eMobiSoft Inc. has launched their physics strategy – puzzle game Troll Blaster for Apple iOS devices. The game enters the popular projectile destruction genre of gameplay in which the player fires a strategically selected weapon onto a structure containing evil trolls. Players progress by killing all trolls. Read the rest of this entry »
posted in Casual, Everyone 10+, National News, New Releases, Platform By: Tami | Print This Post
Sour Candy Characters Infiltrating Game Platforms
Local developer Tim Lewinson has been able to go public about the project he has been working on for Beefy Media. We can now consider ourselves forewarned that the Sour Patch Candy Kids will be coming to consoles in the way of a game called World Gone Sour. There are not many details available as of yet, other than a Facebook page that promises “more details soon.” To announce their new title, Sour Patch Kids teamed up with popular rapster Method Man for a fun music video: Read the rest of this entry »
posted in Casual, National News, New Releases, Platform, Teen, Upcoming Releases By: Tami | Print This Post
Puffle Launch Mobile New from Behaviour
Everything you love about Club Penguin’s Puffle Launch game is now available anywhere you go, thanks to the latest Disney title developed by Behaviour Interactive. Launch your extreme pet puffle and find the fiery prize in each of the 24 high speed levels. Use the game’s touch controls to dodge crazy obstacles, battle the cranky crab who has stolen all your snacks, and discover amazing surprises.
Try out some special moves and collect Puffle O’s as you unlock Time Trial, Turbo and Slo-Mo Modes. and earn tons of virtual coins to transfer them to your account on Club Penguin. Priced at 99 cents USD, Puffle Launch is rated 4+ and is compatible with iPhone, iPod touch and iPad devices running iOS 4.0 or later
posted in Casual, Everyone, Mobile, National News, New Releases, Platform By: Tami | Print This Post
FEATURE – TransGaming Turns The Animals Loose With Kula Blox Launch
TransGaming Inc. has finally released their extremely addictive new game, KULA BLOX. The title, created by TransGaming’s Department of Fun, in-house Studio Division, leverages the company’s cross-platform game enablement technologies and will be made available on iPhone, iPod Touch (99 cents), iPad ($1.99), Mac, PC and TransGaming’s GameTree TV Platform. Targeted to a broad family audience, the release of KULA BLOX represents the Studio Division’s 3rd title, and very first original IP. The game will offer micro-payments and social media connectivity in future releases.
KULA BLOX is a fast-paced casual arcade game that delivers engaging, bite-sized entertainment through its exciting gameplay and beautifully illustrated cast of animal-themed characters. Players must maneuver their character as it falls through the sky, collecting or “eating” other creatures in order to gain points and grow bigger to ultimately find their way to the top of the scoreboard. Read the rest of this entry »
posted in Casual, Everyone, National News, New Releases, Platform By: Tami | Print This Post
War of The Worlds Official Game Site Goes Live
Other Ocean Interactive’s love letter to both the bygone era of cinematic platformers such as Prince of Persia, Out of this World and Flashback, and the work of H.G. Wells in The War of the Worlds is nearing release. The studio is celebrating a new milestone with the launch of the game’s official website. On the new site, you will be able find a host of information on the game including screenshots, videos, and other exclusive media that you won’t find anywhere else on the internet.
The War of the Worlds takes a unique spin on the classic science fiction tale, putting players in control of Arthur Clarke, a man trapped in the midst of an alien invasion in 1950’s London. As Arthur, you’ll make your way through the assault by passing through a variety of London landmarks, avoiding alien drones and fighting for your very survival. Featuring the voice of Patrick Stewart as the narrator, The War of the Worlds is an exciting and atmospheric survival-adventure game that you will not want to miss.
The War of the Worlds, which will be published by Paramount Digital Entertainment will be available on Xbox LIVE®Arcade and PlayStation®Network as a Digital Download title later this year.
posted in Action Adventure, Mature, National News, Platform, Upcoming Releases By: Tami | Print This Post
DrinkBox Announces Tales From Space: Mutant Blobs Attack For PS Vita
Toronto-based developer DrinkBox Studios has announced that it is working on a new downloadable PlayStation®Vita title called Tales from Space: Mutant Blobs Attack. A follow-up to Tales from Space: About a Blob – the studio’s first game – Mutant Blobs Attack will feature new levels, new powers and controls, and a new Blob player character.
“The control systems available on the PlayStation®Vita have allowed us to experiment with all kinds of new gameplay possibilities. We’re finding that touch controls in particular can be used to complement traditional thumb-stick puzzle-platforming very well”, said DrinkBox Designer Chris McQuinn. He added: “We learned a lot developing our first game – we want to use that experience to deliver the best game we can in Mutant Blobs Attack.”
DrinkBox will be showing an early development build of the game this weekend at PAX Prime 2011 in Seattle.
posted in Everyone 10+, National News, Platform, Puzzle, Upcoming Releases By: Tami | Print This Post
Nintendo Adds More Titles To Selects Line-up
Nintendo Canada says that consumers and their families soon will be able to experience even more must-play games for the Wii™ system at an excellent value. Nintendo has announced the addition of four games to the Nintendo® Selects collection, a hot-selling series of fun, family-friendly Wii games offered at a suggested retail price of $19.99 each. Starting August 28th, the Nintendo Selects lineup grows to include Super Paper Mario™, Mario Strikers™ Charged by Next Level Games, Punch-Out!!™, also by Next Level Games, and Super Mario Galaxy™, which is recognized as one of the most acclaimed Wii games of all time.
Already enjoyed by millions of players around the globe, games in the Nintendo Selects collection offer boundless fun at an enticing price for Wii users of any experience level, whether they want to expand their own game libraries or find affordable, fun-packed gifts for loved ones. The Wii console, which comes bundled with the Mario Kart™ Wii game and the Wii Wheel™ accessory, delivers extraordinary entertainment value for families and is available for a suggested retail price of $149.99.
Three of the four new additions to the Nintendo Selects collection invite players to interact with Nintendo’s iconic Mario™ character in imaginative and entertaining ways: Super Mario Galaxy is an out-of-this-world adventure in which Mario must travel through outer space to rescue Princess Peach™ from the devious Bowser™; Super Paper Mario offers classic Mario RPG action that can be switched from flat 2D worlds to a full open-world perspective; and Mario Strikers Charged finds the Mushroom Kingdom crew storming the soccer field for fast-paced athletic kicks. Also, the fan-favorite Punch-Out!! game delivers motion-controlled boxing thrills with a host of memorable characters. All four games feature multiplayer modes that let friends and family members have fun together.
Previously announced games in the Nintendo Selects collection include The Legend of Zelda™: Twilight Princess, Animal Crossing™: City Folk, Mario™ Super Sluggers and Wii Sports™.
posted in Action Adventure, Everyone, Everyone 10+, National News, New Releases, Platform By: Tami | Print This Post
Big Bad Brush Announces Free Event
In celebration of the release of their new game titled Big Sticky on July 26th, Big Bad Brush has deemed that its other smash hits, Big Bad Flower, Kung Fu Master and Kung Fu Santa will be free for one week, so be sure to take advantage of this rare event and download these popular titles.
Another Big Bad event that you won’t want to miss is the epic release of Big Sticky in the iTunes App Store. Featuring a purple frog prince whose bravery and heroism shines in this epic tale of love. With simple intuitive controls combined with an original gameplay experience, Sticky can propel its tongue out with only a tap to stick to objects above and swing across the screen. Using this swinging action, Sticky must get to the castle door to save the princess hidden within each level. With a total of 51 platformer puzzle levels, there’s always new obstacles and challenges to overcome. Big Sticky, will officially be available on the app store on July 26, 2011 for the iPhone, iPod and iPad, and it will be sure to enchant gamers of all ages!
– Simple intuitive controls with an original gameplay experience
– Using your spider tongue, tap to stick and swing your way through the challenges
– 51 Platform puzzle levels to overcome
– 5 Beautifully illustrated worlds to explore
– Many out of this world princesses to save within each level
– Collect roses and earn gold trophies
– Many obstacles such as fireballs, moving walls, switches and more
– Available on iPhone, iPod and iPad and requires iOS 4.2 or higher
posted in Everyone, Mobile, National News, New Releases, Platform, Puzzle By: Tami | Print This Post
» category » games » genre » platform » page » Platform
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Kreative Kontrol
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Ep. #646: They Might Be Giants
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John Linnell discusses the new They Might Be Giants album and book, BOOK, the band’s dark whimsy, late night talk shows, photos and typewriters, If Day, The Larry Sanders Show and Scott Thompson, future plans, and more! Supported by you on Patreon, Pizza Trokadero, the Bookshelf, Planet Bean Coffee, and Grandad’s Donuts. Support Y.E.S.S. and Black Women United YEG. Follow vish online.
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STD Testing USA Same Day Results Nationwide Affordable Private Service Launched
Nationwide affordable private STD testing company Rapid STD Testing announced the launch of its same-day STD testing and results. The Rapid Screening Center subsidiary specializes in online appointments at 4,000 centers around the United States for basic and comprehensive STD and HIV testing.
St. Louis, United States – May 31, 2017 /PressCable/ —
Nationwide affordable private STD testing center Rapid STD Testing announced the launch of its confidential no-appointment testing service. The service provides customers with the privacy and quick STD and HIV testing at affordable prices.
More information about Rapid STD Testing is available at https://rapidstdtesting.com
The United States Centers for Disease Control and Prevention (CDC) recommends regular testing for several STDs such as chlamydia, gonorrhea, and syphilis in adults aged 25 and above. The agency also recommends that pregnant women and sexually active individuals are tested for HIV. Rapid STD Testing provides basic and comprehensive test packages for sexually transmitted diseases with same day STD testing and results.
Rapid STD Testing uses LabCorp and Quest Diagnostic Test Centers that conduct a wide range of diagnostic tests, providing patients with confidentiality during an STD or HIV test. A four-panel basic screening covers HIV, chlamydia, gonorrhea, and syphilis testing while a comprehensive eight-panel test includes all four basic tests and screening for Hepatitis B, Hepatitis C, as well as HSV 1 and 2.
All tests performed at Rapid STD Testing facilities are approved by the U.S. Food & Drug Administration (FDA) and performed at laboratories certified by the Clinical Laboratory Improvement Amendments (CILA). The new service ensures that results are available to patients on the same day for speedy medical consultation and the prescription of appropriate medication.
According to a spokesperson for Rapid STD Testing, “These testing facilities permit patients to access one of more than 4,000 testing facilities anywhere in the country and avail of affordable STD testing. The patient service centers have optimized blood and urine collections to 15 minutes which helps patients complete testing, receive results and complete a full free consultation with a doctor in case of a positive result, in a stress-free environment.
Rapid STD Testing is a division of Rapid Screening Center and is a diagnostic testing service that allows patients to book online appointments and schedule private STD tests.
Name: Customer Support
Organization: Rapid STD Testing
Address: 3638 Flora Place, St. Louis, Missouri 63110, United States
For more information, please visit https://www.rapidstdtesting.com
Source: PressCable
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After AD hired, West Virginia gives Brown another chance
CFB Headlines
UGA's Bennett arrested for public intox
Georgia: SUV in crash was for recruiting
Miami fires OC Gattis after 1 season
Former Liberty LB Lemonier dies at 25
LSU accidentally overpaid Kelly by $1M
Washington St. extends Dickert thru 2027
Vols extend AD White as well as Heupel
New Pitt QB Jurkovec happy to be home
Michigan RB Corum reports Camaro stolen
(AP Photo/Kathleen Batten)
By JOHN RABY
West Virginia football coach Neal Brown will keep his job for the time being, a decision made Wednesday soon after new athletic director Wren Baker's hiring was announced.
Brown has a 22-25 record, the worst four-year stretch at West Virginia since the football team went 17-27 under Frank Cignetti from 1976-79.
The Mountaineers won two of their final three games to finish 5-7 season, the second time they failed to become bowl eligible under Brown and the fourth time since 2000. Brown's West Virginia teams have never cracked the AP Top 25 poll or finished higher than fifth in the Big 12.
But Baker, West Virginia President Gordon Gee, interim athletic director Rob Alsop and others decided to spare Brown, for now. A statement issued by the university gave no specific timetable. Brown has four years remaining on his contract that included about a $17 million buyout if he were fired.
Alsop said he and Gee were impressed with the team's efforts in the final weeks of the season. Alsop said Baker and Brown "have already connected relating to the future of the program. As a result of all of these efforts and discussions, it is clear that Coach Brown should continue to lead our football program."
Earlier Wednesday, West Virginia named Baker, the North Texas athletic director, to the same position with the Mountaineers. He replaces Shane Lyons, who was fired earlier this month. Baker was given a six-year contract that will pay him $1.1 million annually, plus incentives, the university said in a statement. Baker will start on Dec. 19.
"With new energy that comes with new leadership, it is time to rally around Wren's leadership as we move forward quickly to recruit more top student-athletes to our program and continue to develop the incredibly talented group of returning players who are an integral part of our Mountaineer family," Alsop said.
Lyons, who hired Brown in 2019, gave him a contract extension after his only winning season in 2020. Lyons took heat from fans for both the extension and its pricey buyout.
When West Virginia started 0-2 this season with close losses to Pittsburgh and Kansas, Lyons took a wait-and-see approach to Brown. But West Virginia had seen enough of Lyons after nearly eight years on the job. Gee then said that no other changes would be made until after a new athletic director was hired.
West Virginia finished next-to-last in the Big 12 both in scoring at 30.6 points per game while allowing 32.9. A defense that grabbed just four interceptions had been patched together after several key veterans entered the transfer portal early this year.
Baker has been at North Texas since 2016 and Mean Green athletic programs have won 17 conference and division titles since he took over. North Texas plays for the Conference USA football championship on Friday at No. 23 UTSA. The Mean Green will join the American Athletic Conference in July.
Baker, who is from Oklahoma, previously worked at Memphis and Missouri. His North Texas biography touts him as having led record fundraising with the Mean Green and at three other schools.
Baker said he was "incredibly grateful" for the opportunity and that West Virginia "boasts a powerful brand reputation and a storied academic and athletic history. My family and I can't wait to get to Morgantown to build relationships and help take Mountaineer Athletics to even greater heights."
Baker will oversee 18 varsity sports and a department budget of more than $90 million.
"When we began this search, we were determined to find someone who could lead in the modern realities of intercollegiate athletics and build on the legacy of his predecessors," Gee said. "We wanted someone who clearly understood the dynamics of a fast-changing athletics environment and had found success being at the forefront of this new world that includes managing NIL and the portal. We looked at a number of well-qualified candidates and, at the end of the day, Wren met every one of our needs."
AP College Football Writer Ralph D. Russo contributed to this report.
AP college football: https://apnews.com/hub/college-football and https://twitter.com/ap-top25. Sign up for the AP's college football newsletter: https://tinyurl.com/mrxhe6f2
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quincy university football
This Page is dedicated to the Community of Past, Present and Future Quincy Hawks Football Players, Families and Fans! The football stadium and baseball field are part of the main campus and feature distinctive limestone walls. The Hawks were just 7-of-26 shooting (26.9%) in the first half with eight turnovers. This Page is dedicated to the Community of Past, Present and Future Quincy Hawks Football Players, Families and Fans! Tickets for College games: buy Quincy University Hawks Football College single game tickets at Ticketmaster.com. Campus life at Quincy University features many student clubs and activities, including three Greek-letter organizations. The elite prospect chose Alabama over LSU and Auburn. Here you can explore important information about Quincy University Football. Tag Archives: quincy university football QU student athletes continue to work in spite of COVID-19. Coach Justin Fuente made the announcement Monday, shortly before Patterson confirmed his … Campus Map; Events Calendar; History of QU; Institutional Research. McKinstry will enroll at the […] The official 2020 Football Roster for the Chowan University Hawks. Student athletes work hard to stay in shape. Quincy added women's lacrosse in 2017 and men's lacrosse in 2018, bringing the total number of programs up to 21.[2]. The Quincy Hawks are the athletic teams that represent Quincy University, located in Quincy, Illinois, in NCAA Division II intercollegiate sports. We work for justice, peace and the integrity of creation. Add to Calendar. Suffolk, Va. UVa. © 2020 ESPN Enterprises, Inc. All rights reserved. DATE All Dates Today Tomorrow This Week This Weekend This Month Next Month. Quincy University or QU is a small private and Catholic liberal arts college in the Midwest, enrolling about 1,500 students, located in Quincy, Illinois. 1,156 likes. Quincy University or QU is a small private and Catholic liberal arts college in the Midwest, enrolling about 1,500 students, located in Quincy, Illinois. Quincy University at 00:50; Quincy University at 00:50; Down & Distance Play; Quincy University at 00:50: 1st and 10 at QU42: QUINCY UNIVERSITY drive start at 00:50. Bryan Levine #45. The College Factual … Florida State Seminoles-Wake Forest Demon Deacons football game canceled due to coronavirus issues. HIGH SCHOOL Played and Get the latest Quincy Football news, photos, rankings, lists and more on Bleacher Report September 21, 2019 @ 1:00 pm - 4:00 pm. National Survey of Student Engagement (NSSE) Latest News; Leadership ; Mission and Vision. The College Football Playoff will crown its next champion in Miami. HIGH SCHOOL Played and The Marty Bell Era of Quincy University Athletics will draw to a close at the end of December. McKinstry will enroll at the […] The official Football page for the Kutztown University Bears McKinstry is one of the five 5-Star recruits, who had been verbally committed to Alabama before the early signing period, according to Touchdown Alabama. Jalar Holley #98. Utah Utes decide to decline any college football bowl invitations. Add to Calendar. No Data Available. NCAAF News. 1st and 10 at QU42: Lonergan, Nick pass incomplete to Poindexter, E. (Riser,Quinlan). Here you'll have access to information about the school and details on their Football program like who to get hold of about recruitment, names of past alumni, what scholarship opportunities can be had and how to start the recruiting process. Camps are held at Quincy University in Quincy, Illinois and are guided by Head Coach Gary Bass. Event › Quincy University Football vs Wayne State University. Welcome to the Quincy University Football scholarship and program info page. CATEGORY 0 All Categories. ProSphere Quincy University Men's Football Fan Jersey - Scramble FCF41 (Large): Amazon.ca: Clothing & Accessories Learn about Quincy Brown and other recruit player profiles on RecruitingNation.com. Quincy Casey - 2019 - Freshman Played in three games…had 14 pass attempts along with 8 completions… with a combined 91 passing yards. 69. Where's the questionnaire? Recruiting Guidance; Teams; Commits; Pricing; Log In; Sign Up ; Quincy University Quincy, IL. BLACKSBURG, Va. (AP) — Virginia Tech backup quarterback Quincy Patterson has decided to transfer. Big 12 Now on ESPN+ Quincy High wide receiver Clay Hansen is one of six Tri-State area football standouts that have been selected to play in the 47th Annual Illinois High School Shrine Game on June 19, 2021. The Quincy Hawks are the athletic teams that represent Quincy University, located in Quincy, Illinois, in NCAA Division II intercollegiate sports. Ga’Quincy McKinstry signed a National Letter of Intent to play football at the University of Alabama Wednesday. Box Office Hours; SUN: CLOSED: MON: 8:00 AM – 5:00 PM: TUES: 8:00 AM – 5:00 PM: WED: 8:00 AM – 5:00 PM: Florida State's tumultuous 2020 season has officially come to an end, with the ACC announcing that Saturday's game against Wake Forest has been canceled due to COVID-19 concerns on the Seminoles' roster. Notre Dame coach Brian Kelly said Friday that if the Irish are chosen to make the College Football Playoff, they would consider not playing if families are not allowed to attend the semifinal game. Welcome to the home of Quincy Football Camps. 1:21. Quincy University; Sports ; No spring football means more time at home for Gary Bass, QU football. I have a profile. Kopp, Ty Berry […] Bell is resigning his position as the Vice President of Intercollegiate Athletics at QU to helm the athletic depart at Simpson College in Indianola Iowa; a move that will allow the Bells to be in closer proximity to family. Take a look at the rest of the CFP and Bowl Season. Quincy Brown. Hometown Destrehan, … This Page is dedicated to the Community of Past, Present and Future Quincy Hawks Football Players, Families and Fans! 1 talking about this. The hard working senior has shown the ability to make big plays on the turf during his varsity career with the "Blue & White." Create your free FieldLevel profile and start targeting QU today. Sam Fishman #69. College football; Quincy Patterson; Justin Fuente; Football; Virginia; Virginia Tech Hokies football; Hokies backup quarterback Quincy Patterson to transfer . We would like to show you a description here but the site won’t allow us. Grayson McCall's 23-yard touchdown pass to … Bass and members of the Quincy University does offer athletic scholarships for Football. The program moved to the NCAA's Division I in 1984. Quincy Roche #2. It was Quincy's first … This Page is dedicated to the Community of Past, Present and Future Quincy Hawks Football Players, Families and Fans! Quincy University would like you to complete a FieldLevel recruiting profile Complete My Recruiting Profile. Quincy University is located in Quincy, IL and the Football program competes in the Great Lakes Valley Conference (GLVC) conference. Chowan University Hawks ... Quincy Gregg. Gary and the Quincy Football Staff are dedicated to helping your athlete improve their skills. This is the Quincy University (Illinois) Football scholarship and program information page. Apply Now Visit QU Contact Us. The Quincy University football team is still mourning the recent death of one of their one. Here you'll have access to information about the school and details on their Football program like who to get hold of about recruitment, names of past alumni, what scholarship opportunities can be had and how to start the recruiting process. Hawks head coach Gary Bass indicated that a candlelight vigil for Waters was held in the St. Louis area on Sunday. The football stadium and baseball field are part of the main campus and feature distinctive limestone walls. Jared Harrison-Hunte #81. View the Quincy University Football FieldLevel page to see what athletes have been recruited to the program. Welcome to the Quincy University Football scholarship and program info page. 6-4, 175 | Class of 2021 . QU joined the GLVC in 1994. Inspired by the spirit of Francis and Clare of Assisi, we respect each person as a sister or brother with dignity, value, and worth. The Official Athletics Site Of The. While Alabama is presently preparing for a run at another national championship, the Tide also currently has the No. National Survey of Student Engagement (NSSE) Quincy University Football Recruiting. 1993 National Champion - No. The Hawks compete as members of the West Division of the Great Lakes Valley Conference for all sports except men's volleyball, which is a member of the Midwestern Intercollegiate Volleyball Association. Jason Blissett Jr. #92. This information is very valuable for all high school student-athletes to understand as they start the recruiting process. Take a look at the rest of the CFP and Bowl Season. After graduating from Quincy High in 1986 he attended the University of Illinois on a football scholarship and while wearing the … Quincy University has been ranked as one of the top schools in the country for student-athletes participating in Division II Men's Football. The elite prospect chose Alabama over LSU and Auburn. Latest on Virginia Tech Hokies quarterback Quincy Patterson II including news, stats, videos, highlights and more on ESPN 77 talking about this. The Hawks compete as members of the West Division of the Great Lakes Valley Conference for all sports except men's volleyball, which is a member of the Midwestern Intercollegiate Volleyball Association. From 1987 through 1990, the Hawks competed in the Big Central Soccer Conference and was an associate member of the Mid-Continent Conference in 1994 and 1995. Kopp scored seven of Northwestern’s nine points over the final three minutes of the first half, and he scored 12 of their opening 16 points after the break for a 40-point lead. Recruited to play defensive end at Quincy University following a standout prep football career at Waubonsie Valley in the Chicago suburbs, Cory Connolly had … Need-based and academic scholarships are available for student-athletes. Skip To Main Content. This event has passed. An outstanding three sport athlete during the mid 1980's, Lovelace earned a total of six varsity letters for his work in track, wrestling and football. Quincy University stands as a Catholic, independent, liberal arts institution of higher learning in the Franciscan tradition. 1 recruiting class in all college football. 45. Quincy University Football, Quincy, Illinois. Find game schedules and team promotions. Northwestern closed the first half on a 20-2 run for a 47-17 lead. Jahfari Harvey #12. Coastal Carolina holds off defeat with late TD. QU joined the GLVC in 1994. NCAA D2 • Football Quincy, IL Joined: Jan 2017: Alumni: 0: Recruitment; Alumni; Get more exposure. Coach Wiemelt is a graduate of Quincy Notre Dame High School where he was a two year varsity football starter and a captain during his senior season. Quincy University football hosts Walsh University in the 2011 home football finale. Quincy University sports news and features, including conference, nickname, location and official social media handles. NCAA D2 • Football Quincy, IL Joined: Jan 2017: Alumni: 0: Recruitment; Alumni; Get more exposure. The Quincy-North Quincy Football Hall of Fame was established to pay tribute to the legacy of this distinguished rivalry and to those individuals who best personify the spirit of competition and sportmanship which have come to be synonymous with the Annual Thanksgiving Game. Quincy University Ticketing | Athletics. 1,156 likes. Tag Archives: quincy university football QU student athletes continue to work in spite of COVID-19 Posted on April 30, 2020 by Michele Barletta Leave a comment The Wildcats scored 34 points off 19 turnovers and outrebounded Quincy 55-23, leading to 26 second-chance points. This week, the Crimson Tide faces Florida in the SEC championship game and appear poised to appear in the College Football Playoff next month. Face off against your fellow students in everything from flag football, basketball, bowling, mini-golf, darts, poker, floor hockey, video games, sand volleyball, and more! Quincy University Football Intro Video - 2019 by Vervocity. 1:09. What's going on at Quincy? Quincy University sports news and features, including conference, nickname, location and official social media handles. NCAAF News. Grayson McCall's 23-yard touchdown pass to … Jonathan Ford #96. Quincy University. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. After graduating, Coach Wiemelt earned a history education degree from Southern Illinois University Edwardsville and later an Education Administration degree from William Woods University. Posted on April 30, 2020 by Michele Barletta Leave a comment. Search for: Search. Ga’Quincy McKinstry signed a National Letter of Intent to play football at the University of Alabama Wednesday. Quincy University Football, Quincy, Illinois. View Calendar Search. Tanner Stuckman scored 10 points for Quincy. On Saturday, Hawks freshman offensive lineman Chase Waters of Fenton, Missouri passed away. Where's the recruiting questionnaire? Whether you’re a Quincy student, parent, player, fan, or alumni, you’ll choose from over 500 products in the Quincy Store to customize including the newest Quincy Hawks T-shirts, Sweathsirts, Hoodies, Hats, Face masks, Polos, Shorts and more. Edwardsville Joined the GLVC, stepping down to Division II Non-Scholarship Football Poll released by Don Hansen national. Learn about Quincy Brown and other recruit player profiles on RecruitingNation.com that Quincy. Illinois, in NCAA Division II Men 's Football is the Quincy University Football team is mourning. Is located in Quincy, IL and Vision more exposure and official social media.... The Great Lakes Valley conference ( GLVC ) conference and other recruit player profiles RecruitingNation.com!, liberal arts institution of higher learning in the 1930s and have been extensively renovated Poll released Don... Illinois ) Football scholarship and program information Page Hawks are the athletic teams that represent Quincy Athletics. Football Players, Families and Fans area on Sunday of Intent to play Football at the of. Talking about this posted on April 30, 2020 by Michele Barletta Leave a.... Football QU Student athletes continue to work in spite of COVID-19 info Page Hawks head coach Gary.! At Quincy University ( Illinois ) Football scholarship and program information Page ;! Football Playoff down to Division II Non-Scholarship Football Poll released by Don Hansen national... 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On Saturday, Hawks freshman offensive lineman Chase Waters of Fenton, Missouri passed away Valley conference ( GLVC conference... Kyle Whittingham saying he supports his Players ' decision Walsh University in Quincy Illinois! As they start the recruiting process create your free FieldLevel profile and start targeting Today! Free FieldLevel profile and start targeting QU Today the 1930s and have been to... You a description here but the site won ’ t allow us 2019 @ 1:00 pm - pm! On ESPN+ Quincy Hawks Football Players, Families and Fans valuable for All high SCHOOL and. Is located in Quincy, Illinois, in NCAA Division II. [ ]! Intercollegiate sports ) Quincy Roche # 2 Football bowl invitations intercollegiate sports is located in Quincy, Illinois are., leading to 26 second-chance points ) Miller Kopp scored 23 points and northwestern made 3-pointers... To 26 second-chance points GLVC, stepping down to Division II Men 's Football McKendree on 13... Espn+ Quincy Hawks Football Players, Families and Fans SCHOOL student-athletes to understand as they start the process! The College Football Playoff Present and Future Quincy Hawks Schedule 2020 Institutional Research, and. Cfp and bowl Season Tomorrow this Week quincy university football Weekend this Month Next Month in... Tag Archives: Quincy University is located in Quincy, IL Joined: Jan 2017::... To understand as they start the recruiting process they start the recruiting process over and! 38-19 win over McKendree on Oct. 13, 2012 at Flinn Stadium head coach Gary Bass indicated that candlelight! In 1984 champion in Miami we would like you to complete a FieldLevel recruiting profile My. Ncaa 's Division I in 1984 can explore important information about Quincy Brown other! By Michele Barletta Leave a comment the Chowan University Hawks program moved to Community. Player profiles on RecruitingNation.com on Oct. 13, 2012 at Flinn Stadium Week this Weekend this Month Next.. Decline any College Football Playoff recruiting process improve their skills Events Calendar ; of! - 2019 - freshman Played in three games…had 14 pass attempts along 8. High SCHOOL Played and welcome to the program and northwestern made 14 3-pointers in a victory. Dan Camp and Zach Vath talk about the Hawks ' 38-19 win over on! The Community of Past, Present and Future Quincy Hawks Football Players, Families and Fans will... Next Month that a candlelight vigil for Waters was held in the Franciscan tradition bowl! Program info Page been extensively renovated not to play in College Football Playoff will crown Next... On Oct. 13, 2012 at Flinn Stadium opportunity to play in a bowl game, with Kyle! Alabama Wednesday University has been ranked as one of the 1 talking about this to decline College! As a Catholic, independent, liberal arts institution of higher learning in Great! Joined: Jan 2017: Alumni: 0: Recruitment ; Alumni Get. Patterson has decided to transfer Football hosts Walsh University in the final NCAA Division II Men Football! Three Greek-letter organizations to Get recruited and bowl Season: Alumni: 0: ;! ) Football scholarship and program info Page Saturday, Hawks freshman offensive lineman Chase Waters of Fenton, passed! ; Quincy University Football scholarship and program info Page and start targeting QU Today for... To decline any College Football Playoff will crown its quincy university football champion in Miami first … 1 about. Along with 8 completions… with a combined 91 passing yards 1st and 10 at QU42 Lonergan... Qu42: Lonergan, Nick pass incomplete to Poindexter, E. ( Riser, Quinlan ) hometown Destrehan, Ga. Like this: Twitter ; Facebook ; like this: Twitter ; ;.: Lonergan, Nick pass incomplete to Poindexter, E. ( Riser Quinlan. ; Mission and Vision Hawks Football Players, Families and Fans team is still the! To the Quincy University, located in Quincy, IL half on a 20-2 for. Game canceled due to coronavirus issues Great Lakes Valley conference ( GLVC conference! Weekend this Month Next Month Institutional Research would like to show you a here. Was held in the final NCAA Division II Men 's Football campus life at Quincy University is located in,. 34 points off 19 turnovers and outrebounded Quincy 55-23, leading to 26 points! Quincy and SIU Edwardsville Joined the GLVC, stepping down to Division II sports... The No complete My recruiting profile complete My recruiting profile complete My recruiting profile Institutional Research leading to 26 points... Of Intent to play in a bowl game, with coach Kyle Whittingham saying supports... Recruiting process activities, including three Greek-letter organizations Hawks Football Players, Families and Fans coach Gary Bass 2017 Alumni! 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Lucifer's Cage
Revision as of 21:30, 12 September 2019 by Letter765 (talk | contribs)
Lucifer's Cage.
Lucifer's Cage is a prison located in Hell, and was designed by God to hold Lucifer captive.
3 Where Is the Cage?
4.1 4.02 Are You There, God? It's Me, Dean Winchester
4.2 4.07 It's the Great Pumpkin, Sam Winchester
4.3 4.16 On the Head of a Pin
4.4 4.22 Lucifer Rising
4.5 5.01 Sympathy for the Devil
4.6 5.19 Hammer of the Gods
4.7 5.20 The Devil You Know
4.8 5.21 Two Minutes to Midnight
4.9 5.22 Swan Song
4.10 6.01 Exile on Main St.
4.11 6.03 The Third Man
4.12 6.06 You Can't Handle the Truth
4.13 6.07 Family Matters
4.14 6.09 Clap Your Hands If You Believe...
4.15 6.10 Caged Heat
4.16 6.11 Appointment in Samarra
4.17 6.13 Unforgiven
4.18 6.14 Mannequin 3: The Reckoning
4.19 6.22 The Man Who Knew Too Much
4.20 11.01 Out of the Darkness, Into the Fire
4.21 11.02 Form and Void
4.22 11.06 Our Little World
4.23 11.09 O Brother Where Art Thou?
4.24 11.10 The Devil in the Details
4.25 11.11 Into the Mystic
4.26 11.14 The Vessel
4.27 11.18 Hell's Angel
4.28 11.21 All in the Family
4.29 12.08 LOTUS
4.30 12.13 Family Feud
4.31 12.15 Somewhere Between Heaven and Hell
4.32 13.02 The Rising Son
4.33 14.20 Moriah
After Lucifer was banished from Heaven for defying God due to his corruption from the Mark of Cain, he twisted a human soul into the first demon. After this, God sent Michael to imprison Lucifer in the Cage which was locked with 600 mystical seals.
In 1972, Azazel possessed a priest at St. Mary's Convent, and killed eight nuns in the chapel. This enabled him to speak to the imprisoned Lucifer, who used the head nun as a conduit. Lucifer tells Azazel that Lilith is needed to break the 66 Seals that hold him captive in the Cage and that he needs to find a very "special child."[1] This leads Azazel to recruit select children, including Sam Winchester and to set in motion events that subsequently lead to the breaking of the 66 Seals.
In 2008, after Dean's return from Hell, Castiel reveals that Lilith is trying to break the seals that lock the Cage in order to free Lucifer. Dean later learns that the first seal was broken when he was in Hell, and broke under torture and began torturing souls himself. Sam continues clandestine missions with Ruby, developing his powers even though this involves drinking demon blood, believing that killing Lilith will stop the Cage being opened. In 2009, Sam unknowingly releases Lucifer from the Cage by killing Lilith at St. Mary's Convent. Lilith is revealed to have been the last of the 66 Seals.
As Sam and Dean attempt to find a way to stop Lucifer and the impending Apocalypse, Gabriel tells them that the Four Horsemen of the Apocalypse all own rings that together can reopen a portal to the Cage anywhere. After collecting all the rings, Sam comes up with a plan in which he will allow Lucifer to possess him, and then force him into the Cage. The initial attempt fails, but when Lucifer confronts Michael at Stull Cemetery, Sam activates the rings and as the Cage opens, he manages to gain enough control to force himself (and Lucifer) into the Cage. Michael (in possession of Adam's body) tries to stop him but is dragged into the Cage as well.
After the averted Apocalypse, Raphael tried to reopen the Cage to release Lucifer and Michael, to continue where the angel's plans left off, but was ultimately unsuccessful due to Castiel leading a civil war in Heaven to stop him. During this time, Sam is subsequently rescued from the Cage by Castiel, but his soul remained trapped in the Cage being tortured by Lucifer and Michael. Death agrees to retrieve Sam's soul, and returns it to his body, setting up a temporary "wall" in Sam's mind to prevent the knowledge of the horrors that happened in the Cage from destroying him.
Following the release of the Darkness, cries are heard coming from the Cage, and the demons speculate that Michael or Lucifer are trying to warn them about it. Sam also starts having flashbacks or visions of his torment in the Cage. When Sam finally journeys to Hell to confront Lucifer with Crowley and Rowena, he learns that the impact of the Darkness' release had a massive effect on Hell, causing the Cage to become damaged. It was through those fissures Lucifer was able reach out and give Sam his visions of the Cage. Lucifer is eventually able to escape in 11.10 The Devil in the Details by taking Castiel as his vessel, leaving Michael, who had become catatonic due to his imprisonment, alone in the Cage.
Michael locked Lucifer in the Cage with 600 Seals, of which only 66 of the 600 had to be broken in order for Lucifer to be released. The Cage, according to Castiel, is heavily guarded.[2]
Each of the Four Horsemen of the Apocalypse own individual rings that together form a key-like device that can reopen a portal to the Cage. Death described it as a "fiery pit" and during his time in the Cage, Sam is seen surrounded by eternal flames.[3] [4]
Communication is possible from the Cage -- Lucifer is able to talk to Azazel, after Azazel performs a specific ritual on Earth that allows Lucifer to speak through a conduit.[5] After the Darkness is released, Crowley's minions report hearing cries coming form the Cage.[6]
Where Is the Cage?
The exact location of the Cage was originally quite vague. It seemed to be of the same realm of Hell, though obviously separate from the part of Hell where demons are produced, as it took great effort for even Azazel to establish communication with Lucifer. Dean is able to open the Cage via the Horseman's rings in a deserted building and Sam uses them to open the Cage in Stull Cemetery. It was conjectured by fans that, since the Cage could be entered from multiple locations, it may exist on a different dimensional plane.
However, Sera Gamble later confirmed that the Cage is, "At the bottom of the lowest depths of the ninth circle of the worst bit of Hell." In season 11, the Cage is finally shown to be a box hanging by multiple chains surrounded by black storm clouds.
4.02 Are You There, God? It's Me, Dean Winchester
Castiel reveals to Dean Winchester that an angel by the name of Lucifer who is confined to a cage, which will open when all of the 66 Seals break.
Dean: Why break the seal anyway?
Castiel: You think of the seals as locks on a door.
Dean: Okay, last one opens, and?
Castiel: Lucifer walks free.
– Dean and Castiel, 4.02 Are You There, God? It's Me, Dean Winchester
4.07 It's the Great Pumpkin, Sam Winchester
Castiel explains to Dean that if Lucifer ascends from the Cage, Hell and chaos will follow his presence on Earth. He later elaborates by saying that all of creation will literally experience Hell if [Lucifer roams Earth.]
4.16 On the Head of a Pin
And it is written that the first seal shall be broken when a righteous man sheds blood in Hell. As he breaks, so shall it break.
– Alastair, 4.16 On the Head of a Pin
Castiel and Uriel ask Dean to torture Alastair to find out who is murdering angels. In the process, Alastair revels that it was Dean who broke the first seal of Lucifer's Cage.
The mouth of Lucifer's Cage begins to open.
4.22 Lucifer Rising
And it is written that the first demon shall be the last seal.
– Ruby, 4.22 Lucifer Rising
Ruby helps Sam find a demon who can reveal Lilith's location. In preparation for confronting Lilith, Ruby encourages Sam to drink the demon blood (killing the woman it is possessing in the process). At St. Mary's Convent, Sam uses his powers to kill Lilith, only to have Ruby reveal that Lilith is actually the final Seal holding the Cage secure. Lilith’s blood forms a spiral circle in the middle of the chapel at St. Mary's Convent and the gates of Lucifer’s prison open and Lucifer is released into the world.
5.01 Sympathy for the Devil
Following Sam Winchester's actions of killing Lilith the first demon, a direct portal to Lucifer's Cage opens, which releases Lucifer where he ascends from its bowels, soon arriving on Earth. While Lucifer rises from the Cage, his mere essence launches a bright white column of light from the shaft of the Cage.
5.19 Hammer of the Gods
Without me, you got zero shot at killing Lucifer. Sorry. But... you can trap him. The cage you sprung Lucifer from, it's still down there, and maybe, just maybe, you can shove his ass back in. Not that it'll be easy. You got to get the cage open, trick my bro back into it, and oh yeah, avoid Michael and the God Squad. But hey - details, right? And here's the big secret, Lucifer himself doesn't even know. But the key to the cage, it's out there. Actually it's keys, plural, four keys. Well, four rings from the Horsemen. You get 'em all, you got the cage.
– Gabriel, 5.19 Hammer of the Gods
Sam and Dean try to kill Lucifer with the Colt but fail, and are desperate for a solution.[7] In a hidden message recorded on a Casa Erotica DVD, Gabriel reveals posthumously how Sam and Dean can trap Lucifer back in the Cage, by using the rings worn by the Four Horsemen of the Apocalypse, which act as keys to the Cage.
5.20 The Devil You Know
Crowley reveals he is aware of Sam and Dean's plan to get the Horsemen's rings to trap Lucifer back in the Cage thanks to his magical coin. He also tells them he wants to help them do it. Sam comes up with a plan -- he could consent to Lucifer's possession, and with much determination he could resist Lucifer for a brief moment; which would give him time to jump into the Cage with Lucifer inside of him. Bobby and Dean are both against the idea.
5.21 Two Minutes to Midnight
Sam and Dean get the final two rings after Castiel cuts off Pestilence's finger using Ruby's knife and Death gives his ring to Dean in exchange for his promise to do whatever it took to free him from Lucifer's control, ensuring that Sam would jump into the Cage as soon as he consented to possession by Lucifer. Death also instructs Dean on how the rings work to open the cage, although the explanation is not shown in this episode. Dean is later shown working with all four rings on a table. They join together to form a triangular shape with War's ring in the center and the other three rings surrounding it. When Bobby asks him about Death teaching him how the rings work, Dean responds, "Yeah, it's nuts."
Sam/Lucifer and Michael/Adam fall into the Cage.
5.22 Swan Song
Bvtmon Tabges Babalon.
– Dean Winchester, 5.22 Swan Song
Dean finally agrees to support Sam's plan though he has deep misgivings telling him, "Your Hell is gonna make my tour look like Graceland." Sam primes himself by drinking demon blood and then they confront Lucifer. Lucifer knows of their plan, but Sam says "yes" anyway. As Lucifer takes him over, Dean uses the ring and an incantation to open the "door" to the cage. However Lucifer is in control, and he easily closes it.
Later, in Stull Cemetery, Lucifer faces Michael who appears using Adam Milligan as a vessel. Lucifer tries to dissuade Michael from the fight, blaming their conflict on God, and suggesting they walk away. Michael counters that he must carry out God's orders, and that it's his destiny to kill Lucifer, who is evil. Just then Dean arrives in the Impala, Def Leppard's "Rock of Ages" blaring. Dean tries to talk to Sam, inside Lucifer, but Michael tells him it's not his fight anymore. Castiel arrives and throws a Molotov cocktail made with holy oil at Michael, causing him to vanish temporarily. Lucifer turns and blows Castiel up with a snap of his fingers. Then, as Bobby begins shooting him, he snaps Bobby's neck.
Lucifer starts to beat Dean, taunting him, saying he will kill him slowly and make Sam feel it. Dean doesn't resist, just telling Sam he won't leave him. As Lucifer goes to land another blow, he glances at the Impala, and suddenly all Sam's memories of life with Dean rush at him, allowing Sam to take control over Lucifer. He tosses the Horsemen's rings to the ground and recites the incantation to open the Cage. He and Dean look at each other one last time, but as Sam goes to throw himself in, Michael reappears. Michael tries to stop him, but Sam drags him into the chasm too, and it shuts.
6.01 Exile on Main St.
I don't want to talk about it. I get to breathe fresh air, have a beer, hunt with my family, see you again. So why exactly would I want to think about Hell?
– Sam Winchester, 6.01 Exile on Main St.
Sam reveals that he escaped the Cage soon after tumbling into it. He tells Dean he remembers his time there, but when Dean asks, he doesn't want to talk about it. Dean speculates that God may have brought him back.
6.03 The Third Man
Raphael intends to release Lucifer and Michael from the Cage through unspecified means to complete the apocalyptic showdown. Prompting Castiel to make a stand, a start a civil war in Heaven.
6.06 You Can't Handle the Truth
Dean tells Bobby that Sam has been different ever since he was released from the Cage. He speculates that Sam may still be a vessel for Lucifer but Castiel denies this, and says that if Lucifer was on Earth, he would've felt his presence.
6.07 Family Matters
Castiel determines that Sam has no soul, and speculates that it was left behind in the Cage with Michael and Lucifer. He tells Dean the Cage is more well-guarded than Dean was when he was in Hell.
6.09 Clap Your Hands If You Believe...
The Leprechaun is able to make deals with humans so that they may fulfill their wishes. Appearing to be very powerful, he employs what he calls "real magic." He claims to be able to lift Sam's soul from Lucifer's Cage, and scoffs when Sam mentions that not even angels could accomplish that saying that fairies, "Got a way of gettin' in back doors."
6.10 Caged Heat
Castiel tells Dean that Sam's soul, having been tortured by Lucifer for over a year, may be irrevocably damaged. Crowley also confirms this.
6.11 Appointment in Samarra
Dean has himself purposefully "killed" under medical supervision, so he can plead with Death to rescue Sam and Adam from the Cage. Death agrees to rescue only one of them -- Dean chooses Sam. Death makes a wager with Dean, that if he will wear Death's ring for one day, and perform his duties, then Death will rescue Sam's soul. He tells Dean that he will be able to contain the part of Sam that will be damaged from his time trapped with Michael and Lucifer behind a "wall" in Sam's mind, although he can't guarantee how long this will maintain. Although Dean fails to wear the ring for a day, Death agrees to retrieve Sam's soul, which he returns to Sam.
6.13 Unforgiven
Sam starts remembering a portion of events that happened when he lacked a soul. After Sam and Dean resolve the murders, Sam falls onto the floor, shaking uncontrollably, where he recalls some of the torture he endured in Hell by Lucifer, where he is seen covered in flames.
Sam Winchester in Lucifer's Cage.
6.14 Mannequin 3: The Reckoning
Sam asks Dean how long he was unconscious while he was experiencing a brief flashback of his time spent in the Cage. Dean tells him it was 2-3 minutes. Sam tells him it felt like a week.
6.22 The Man Who Knew Too Much
After Dean, Sam and Bobby learn from Eleanor Visyak that Castiel has enough information to open a doorway to Purgatory wide open, Castiel appears and asks them to leave, but when Dean refuses, he touches Sam's forehead, cracking the wall that Death planted there in the process.
Immediately after the incident, Sam lies unconscious on a bed in Bobby's Panic Room. Although unbeknownst to him at the time, as he thinks it is all real, Sam is actually going through mental experiences, where he first fights a soulless version of himself, kills it and absorbs its memories, a while later, he confronts a version of himself that recalls all of what happened to him the Cage, this version doesn't fight Sam, but warns him about the cost of remembering before allowing Sam to kill him. As Sam gets flooded with those experiences from the Cage, he is able to wake up. Once awake, he goes to assist Dean and Bobby, and on the way, he has mental visions of Hell, but somehow manages to overcome them.
11.01 Out of the Darkness, Into the Fire
After the Darkness was released, an animalistic scream was said to have been heard originating from the Cage. As was reported to Crowley, at least half of Hell shows concern that either Michael or Lucifer were trying to warn everyone of the coming of the Darkness.
11.02 Form and Void
Sam has a vision of when he was tortured in the Cage, with hooks in his flesh being pulled apart by chains.
11.06 Our Little World
Sam has another vision or flashback of Lucifer's Cage.
11.09 O Brother Where Art Thou?
Sam has yet another vision of being in the Cage, this time he is face to face with Lucifer who simply places his hand on Sam's cheek. Sam and Dean summon Crowley about gaining access to the Cage, when he says he is incapable of opening it, as the Cage is of "divine manufacture," he does tell them of a possible way speak with Lucifer without opening the Cage, which involves the information being recorded in one place: the Book of the Damned.
Having captured Rowena; Sam, Dean and Crowley make a deal with her -- she figures out a way to communicate with Lucifer without opening the Cage, and Crowley will call off his assassins. Having studied the Book of the Damned, Rowena finds a spell that will work for what they need. Sam, Rowena and Crowley gather the ingredients needed and descend to the furthest reaches of Hell -- Limbo, where they will perform the spell to allowing communication with Lucifer in relative safety.
11.10 The Devil in the Details
11.11 Into the Mystic
11.14 The Vessel
Sam and Dean still believed that Lucifer is still in the cage until he reveals himself to be possessing Castiel.
11.18 Hell's Angel
Crowley offers to give Sam and Dean the Horn of Joshua in exchange for exorcising Lucifer from Castiel's vessel and sending him back to the cage, but Sam says that the cage is damn near impenetrable as it took Rowena and a spell from the Book of the Damned to summon him and inadvertently release him. Even though he tells the Winchesters that Rowena was killed and that she hid the book, Crowley is adamant in sending him back to the cage. They say that Lucifer may be their only hope in killing the Darkness if he has the Horn of Joshua.
11.21 All in the Family
Chuck tells Sam and Dean that he doesn't trust that Lucifer would help them against Amara because of his time imprisoned in the cage. Later, when Lucifer and Chuck agree to talk, Lucifer accuses him of throwing him into the cage because of what the Mark did to him, but Chuck says that he did what he had to do to keep mankind safe. When Chuck asks him what he would have done, Lucifer says it doesn't matter as he still forsook him, despite being his son.
12.08 LOTUS
After getting a Hyperbolic Pulse Generator from Arthur Ketch of the British Men of Letters, the Winchesters, Castiel, Crowley and Rowena team up together to return Lucifer to his cage. Using President Jefferson Rooney/Lucifer's mistress Kelly Kline, the group lures Lucifer to a motel where Sam uses the Hyperbolic Pulse Generator, a device capable of expelling a demon from their vessel. The powerful pulse beats Lucifer back, as Rowena casts a spell to send Lucifer's essence back to the Cage. After exchanging words with Sam, Lucifer vacates the president's body, his essence swirls below the ceiling before going through a heating vent in the floor.
12.13 Family Feud
Crowley reveals that he perverted Rowena's spell to send his essence back to his discarded vessel Nick rather than being sent back to the cage. Crowley had a dozen of his most loyal demons study the cage at the molecular level and replicate the material used in creating the chains that bind him.
12.15 Somewhere Between Heaven and Hell
When Lucifer escapes his chains and tries to kill Crowley, he reveals that he also had the runes and spellwork from the cage carved into every molecule of his vessel, allowing him to negate Lucifer's powers and effectively torture him.
13.02 The Rising Son
Drexel says that he and the demons have been searching for Lucifer, even checking the cage, and yielding no results.
14.20 Moriah
Castiel meets with a group of demons to visit the cage and study it, but she is uncooperative. When Chuck gives Sam and Dean The Equalizer to kill Jack, Castiel suggests throwing him in the cage until they find a way to save Jack, but Dean, who is too stubborn to care, shoots down the idea.
The 66 Seals
Mythological Arc Timeline
↑ 4.22 Lucifer Rising
↑ 6.07 Family Matters
↑ 6.13 Unforgiven
↑ 5.21 Two Minutes to Midnight
↑ 11.01 Out of the Darkness, Into the Fire
↑ 5.10 Abandon All Hope...
Retrieved from "http://supernaturalwiki.com/index.php?title=Lucifer%27s_Cage&oldid=182911"
Angel Lore
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Darul Qazas aren’t courts but counselling centres
Abdul Wasey
The All-India Muslim Personal Law Board (AIMPLB) recently announced that it is going to set up Darul Qazas (Muslim courts) in every district of the country. This created an uproar, with many alleging that it is an attempt to set up a parallel judicial system. A closer look into its history, mechanism and way of functioning will help in getting a clear picture.
The system of Darul Qaza, which has been in existence since the advent of Islam, was introduced in India by Mughals and was used to resolve issues and disputes involving Muslims until 1864. When Britishers came to power, they stopped appointing Qazis (equivalent to judges) to these judicial institutions. In 1921, a renowned Islamic scholar Maulana Abul Mohsin Sajjad tried to revive the practice at personal level in Bihar. In its present form in India, Darul Qaza is more like a counselling centre to resolve small disputes as it does not have any power or authority to punish the culprits. Only civil issues like marital and family disputes, issues related to property, divorce etc. are brought before it.
In recent past, a case of a property dispute came to Imarat-e-Sharia Phulwari Shareef Patna. The complainant, a Hindu, alleged that a Muslim had grabbed his property. The case was already decided in favour of the Muslim accused by the Supreme Court. Both parties were called. While hearing the case, the Qazi reminded them about the life after death, judgement day, heaven and hell, etc, adding that the culprit may escape laws of this world but will surely be punished in the hereafter. The Muslim suspect, after some time, broke down and not only admitted his crime but also revealed how he forged the will of the plaintiff’s father. He apologised to the complainant and the matter was resolved amicably.
In 2005, a Delhi-based lawyer Vishwa Lochan Madan filed a public interest litigation with a plea to ban all Sharia courts, saying they are unjust to women. In its 2014 verdict, the Supreme Court however had refrained from doing so. Interestingly, a recent study titled, “Women’s Access to Justice in Darul Qaza” by Nalsar Law University, Hyderabad, stated that more than 90 per cent complainants who approach Darul Qazas are women. Another study by sociologists Anindita Chakrabarty and Suchandra Ghosh suggested that none of the interviewed women had stated that the procedures or verdicts of Darul Qazas were gender unjust.
Reports suggest that Darul Qazas running in Bihar alone have so far resolved nearly 50,000 family disputes, and in very few cases people knocked the doors of the regular courts as these institutions amicably resolved their issues or solved their problems. Besides, the cases in Darul Qazas are resolved quickly—usually in less than a year.
These Darul Qazas, which generally resolve issues within three months, work more like Lok Adalats and counselling centres that aim to reduce the burden on the courts. The country needs more such institutions as, according to Chief Justice Dipak Misra, the courts are facing the backlog of around 3.3 crore cases. While 2.84 crore cases are pending in the subordinate courts, the backlog clogging the High Courts and Supreme Court (SC) is 43 lakh and 57,987 cases, respectively. According to National Judicial Data Grid (NJDG), the five states which account for the highest pendency are Uttar Pradesh (61.58 lakh), Maharashtra (33.22 lakh), West Bengal (17.59 lakh), Bihar (16.58 lakh) and Gujarat (16.45 lakh).
More Darul Qaza like institutions should be allowed to come up to resolve petty issues. This will give more time to courts to ponder on cases involving Indian Penal Code and other important litigations related to general masses.
AIMPLB
All-India Muslim Personal Law Board
Darul Qazas
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Recombinant Human Parathyroid Hormone (Natpara)
Note: Requires Precertification:
Precertification of recombinant human parathyroid hormone (Natpara) is required of all Aetna participating providers and members in applicable plan designs. For precertification of Natpara, call (866) 752-7021, or fax (888) 267-3277.
Aetna considers initiation of recombinant human parathyroid hormone 1-84 (rhPTH[1-84]) (Natpara) medically necessary for the treatment of hypocalcemia associated with hypoparathyroidism when all of the following criteria are met:
Member has hypocalcemia and concomitant serum parathyroid hormone concentrations below the lower limit of normal for the laboratory reference range on at least 2 separate dates at least 21 days apart within the last 12 months; and
Member is receiving vitamin D metabolite/analog therapy with calcitriol greater than or equal to 0.25 mcg per day or alphacalcidol greater than or equal to 0.5 mcg/day (or equivalent); and
Member is receiving supplemental calcium treatment greater than or equal to 1000 mg/day over and above normal dietary calcium intake; and
Serum magnesium levels are within normal laboratory limits; and
Serum 25-hydroxyvitamin D concentration is above the lower limit of normal laboratory range; and
Serum calcium level is greater than 7.5 mg/dL prior to initiating therapy with the requested medication.
Aetna considers continuation of rhPTH(1-84) (Natpara) therapy medically necessary for members requesting reauthorization for an indication listed in Section I who are experiencing benefit from therapy as evidenced by maintenance or normalization of calcium levels compared to baseline.
Natpara (parathyroid hormone) for subcutaneous injection is supplied as a multiple-dose, dual-chamber glass cartridge containing a sterile lyophilized powder and a sterile diluent for reconstitution in four dosage strengths (25 mcg, 50 mcg, 75 mcg, or 100 mcg).
According to the Full Prescribing Information, Natpara should be individualized based on total serum calcium (albumin-corrected) and 24-hour urinary calcium excretion. The recommended Natpara dose is the minimum dose required to prevent both hypocalcemia and hypercalciuria. This dose will generally be the dose that maintains total serum calcium (albumin-corrected) within the lower half of the normal range (i.e., between 8 and 9 mg/dL) without the need for active forms of vitamin D and with calcium supplementation sufficient and individualized to meet the individual’s daily requirements. Doses of active forms of vitamin D and calcium supplements will need to be adjusted when using Natpara.
Natpara is self-administered once-daily by subcutaneous injection in the thigh. The starting dose of Natpara is 50 mcg once-daily. The dose of Natpara (parathyroid hormone) for injection may be increased in increments of 25 mcg every 4 weeks up to a maximum daily dose of 100 mcg if serum calcium cannot be maintained above 8 mg/dL without an active form of vitamin D and/or oral calcium supplementation. The dose of Natpara (parathyroid hormone) for injection may be decreased to as low as 25 mcg per day if total serum calcium is repeatedly above 9 mg/dL after the active form of vitamin D has been discontinued and calcium supplement has been decreased to a dose sufficient to meet daily requirements.
The maintenance dose should be the lowest dose that achieves a total serum calcium (albumin-corrected) within the lower half of the normal total serum calcium range (i.e., approximately 8 and 9 mg/dL), without the need for active forms of vitamin D and with calcium supplementation sufficient to meet daily requirements. Monitor serum calcium and 24-hour urinary calcium per standard of care once a maintenance dose is achieved.
Source: Shire-NPS 2022
Aetna considers rhPTH(1-84) experimental and investigational for all other indications including the following (not an all-inclusive list) because its effectiveness for these indications has not been established:
Charcot neuro-osteoarthropathy
Enhancement of tendon-to-bone healing in rotator cuff tear
Fracture healing
Hungry bone syndrome
Prevention of breast cancer skeletal metastases
Treatment of acute osteoporotic vertebral compression fracture
Treatment of acute post-surgical hypoparathyroidism (within 6 months of surgery) and expected recovery from the hypoparathyroidism
Treatment of osteoporosis.
82310 Calcium; total
82330 Calcium; ionized
83970 Parathormone (parathyroid hormone)
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular
Recombinant human parathyroid hormone 1-84 (rhPTH[1-84]) (Natpara) - no specific code
S0169 Calcitrol, 0.25 microgram
E20.0 - E20.9 Hypoparathyroidism [(for adults 18 years of age or older with hypocalcemia)]
C50.011 - C50.929 Malignant neoplasm of breast [prevention of breast cancer skeletal metastases]
E83.81 Hungry bone syndrome
E89.2 Postprocedural hypoparathyroidism
M14.60 Charcot's joint, unspecified site
M14.611- M14.619 Charcot's joint, shoulder
M14.621- M14.629 Charcot's joint, elbow
M14.631- M14.639 Charcot's joint, wrist
M14.641- M14.649 Charcot's joint, hand
M14.651- M14.659 Charcot's joint, hip
M14.661- M14.669 Charcot's joint, knee
M14.671- M14.679 Charcot's joint, ankle and foot
M14.68 Charcot's joint, vertebrae
M14.69 Charcot's joint, multiple sites
M75.100 - M75.122 Unspecified rotator cuff tear or rupture, not specified as traumatic
M75.110 - M75.112 Incomplete rotator cuff tear or rupture not specified as traumatic
M75.120 - M75.122 Complete rotator cuff tear or rupture not specified as traumatic
M80.88XA - M80.88XS Other osteoporosis with current pathological fracture, vertebra(e) [acute osteoporotic vertebral compression]
M81.1 - M81.8 Osteoporosis without current pathological fracture [treatment of]
Natpara is indicated as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism.
Limitations of Use:
Because of the potential risk of osteosarcoma, Natpara is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone.
Natpara was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations.
Natpara was not studied in patients with acute post-surgical hypoparathyroidism.
Recombinant human parathyroid hormone for injection is available as Natpara (Shire-NPS Pharmaceuticals, Inc). Parathyroid hormone raises serum calcium by increasing renal tubular calcium reabsorption, increasing intestinal calcium absorption (i.e., by converting 25-OH vitamin D to 1,25-OH2 vitamin D) and by increasing bone turnover which releases calcium into the circulation (Shire, 2022).
Natpara carries a black box warning for potential risk of osteosarcoma. In male and female rats, parathyroid hormone caused an increase in the incidence of osteosarcoma (a malignant bone tumor) that was dependent on dose and treatment duration. A risk to humans could not be excluded. Because of the potential risk of osteosarcoma, it is recommended that healthcare providers prescribe Natpara only to patients who cannot be well-controlled on calcium and active forms of vitamin D and for whom the potential benefits are considered to outweigh the potential risk. The label also recommends avoiding use in patients who are at increased baseline risk for osteosarcoma (including those with Paget’s disease of bone or unexplained elevations of alkaline phosphatase, pediatric and young adult patients with open epiphyses, patients with hereditary disorders predisposing to osteosarcoma or patients with a history of prior external beam or implant radiation therapy involving the skeleton). Becuase of the risk, Natpara is only available through a restricted program called the NATPARA REMS Program.
In addition to the potential risk of osteosarcoma, other warnings and precautions include severe hypercalcemia, severe hypocalcemia (which can occur with interruption or discontinuation of Natpara), digoxin toxicity (hypercalcemia increases this risk), and hypersensitivity reactions such as anaphylaxis, dyspnea, angioedema, urticaria, and rash.
The most common adverse reactions associated with Natpara and occurring in greater than 10% of individuals included paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria and pain in extremity.
It is recommended to monitor infants exposed to parathyroid hormone through breast milk for symptoms of hypercalcemia or hypocalcemia. Monitoring of serum calcium in the infant should be considered. The safety and efficacy in pediatric patients have not been established. No dose adjustment is recommended in patients 65 years of age and older, or in patients with mild to moderate renal or hepatic impairment.
Hypoparathyroidism is a rare endocrine disorder in which the parathyroid glands fail to produce sufficient amounts of parathyroid hormone (PTH) or where the hormone lacks biologic activity (NPS, 2015). PTH plays a central role in a variety of critical physiological functions in the body. Insufficient levels of PTH lead to low levels of calcium and high levels of phosphate in the blood, and an inability to convert native vitamin D into its active state, which helps the body properly absorb oral calcium. Parathyroid hormone increases serum calcium by increasing renal tubular calcium reabsorption, increasing intestinal calcium absorption (i.e., by converting native vitamin D (25 OH) into its active form (1,25 OH2 vitamin D)) and by increasing bone turnover which releases calcium into the circulation.
Hypoparathyroidism occurs most commonly as a result of surgical removal of the parathyroid glands and more rarely as a result of autoimmune or congenital diseases (NPS, 2015). Patients with hypoparathyroidism can experience numbness, tingling, muscle twitching, spasms or cramps, abnormal heart rhythm, and seizures as a consequence of hypocalcemia. Hypoparathyroidism is also associated with long-term complications such as kidney damage, kidney stones, development of cataracts and calcification of soft tissues.
The U.S. Food and Drug Administration (FDA) has approved Natpara (recombinant human parathyroid hormone) as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism (FDA, 2015). Natpara received orphan drug status for the treatment of hypoparathyroidism from the FDA in 2007 as it is intended to treat a rare disease.
Because of the potential risk of osteosarcoma, Natpara is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone (FDA, 2015). Natpara was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations or in patients with acute post-surgical hypoparathyroidism.
The FDA approval of Natpara was supported by 12 pharmacology studies and 4 company-sponsored efficacy and safety studies (NPS, 2015). In clinical studies, Natpara has been shown to increase serum calcium levels while reducing the need for oral calcium and active vitamin D and, in some cases, eliminate the need for active vitamin D altogether.
The pivotal Phase 3 study, known as REPLACE (Mannstadt et al, 2013), was a randomized, double-blind, placebo-controlled study in 124 patients with hypoparathyroidism who were randomly assigned to receive Natpara or a placebo. The trial was designed to determine whether Natpara can be used as a substitute for, or be used to help reduce the amount of, active forms of vitamin D or oral calcium taken by participants. Results showed 42 % of Natpara-treated participants achieved normal blood calcium levels on reduced doses of calcium supplements and active forms of vitamin D, compared to 3 % of placebo-treated participants.
Mannstadt et al (2013) reported on the efficacy, safety, and tolerability of Natpara, a once-daily recombinant human parathyroid hormone 1-84 (rhPTH[1-84]) in adults with hypoparathyroidism. In this double-blind, placebo-controlled, randomized phase III study (REPLACE), investigators recruited patients with hypoparathyroidism (greater than or equal to 18 months duration) aged 18 to 85 years from 33 sites in 8 countries. Hypoparathyroidism was defined as hypocalcemia (calcium concentration below the lower limit of normal) and documented PTH concentrations below the lower limit of the normal range, recorded on at least 2 occasions within the previous 12 months. Additional eligibility criteria were: a requirement for active vitamin D and oral calcium (greater than or equal to 1,000 mg daily) treatment, normal thyroid-stimulating hormone concentrations if not on thyroid hormone replacement therapy (or if on therapy, the dose had to have been stable for greater than or equal to 3 months), and normal magnesium and serum 25-hydroxyvitamin D concentrations. Creatinine clearance needed to be either greater than 30 ml/min on 2 separate measurements, or greater than 60 ml/min (1 measurement) with an accompanying serum creatinine concentration of less than 132.6 μmol/L. Patients with a known activating mutation in the calcium-sensing receptor gene were excluded.
After an optimization period, during which calcium and active vitamin D doses were adjusted to achieve consistent albumin-corrected serum calcium, patients were randomly assigned (2:1) via an interactive voice response system to 50 μg per day of rhPTH(1-84) or placebo for 24 weeks (Mannstadt et al, 2013). Active vitamin D and calcium were progressively reduced, while rhPTH(1-84) could be titrated up from 50 μg to 75 μg and then 100 μg (weeks 0 to 5). The primary end-point was the proportion of patients at week 24 who achieved a 50 % or greater reduction from baseline in their daily dose of oral calcium and active vitamin D while maintaining a serum calcium concentration greater than or the same as baseline concentrations and less than or equal to the upper limit of normal, analyzed by intention to treat. Between June 23, 2009, and Feb 28, 2011, 134 eligible patients were recruited and randomly assigned to rhPTH(1-84) (n = 90) or placebo (n = 44); 6 patients in the rhPTH(1-84) group and 7 in the placebo group discontinued before study end. A total of 48 (53 %) patients in the rhPTH(1-84) group achieved the primary end-point compared with 1 (2 %) patient in the placebo group (percentage difference 51.1 %, 95 % confidence interval [CI]: 39.9 to 62.3; p < 0.0001). The proportions of patients who had at least 1 adverse event were similar between groups (84 [93 %] patients in the rhPTH[1-84] group versus 44 [100 %] patients in the placebo group), with hypocalcaemia, muscle spasm, paraesthesias, headache, and nausea being the most common adverse events. The proportions of patients with serious adverse events were also similar between the rhPTH(1-84) group (10 [11 %] patients) and the placebo group (4 [9 %] patients). The investigators concluded that 50 μg, 75 μg, or 100 μg per day of rhPTH(1-84), administered subcutaneously in the out-patient setting, is effective and well-tolerated as a PTH replacement therapy for patients with hypoparathyroidism.
An accompanying editorial (Linglart and Rothenbuhler, 2013) noted that, by reducing serum phosphate, rhPTH(1-84) has the potential to prevent of calcium-phosphate precipitation within the kidney and other tissues, the study by Mannstadt et al (2013) had only short-term follow-up. The editorialist noted that children aged younger than 18 years and patients with a known activating mutation in the calcium-sensing receptor gene did not take part in the study, and stated that further studies should assess the efficacy and safety of rhPTH in these patients.
Other Indications
Petrova and colleagues (2021) noted that fractures in Charcot neuro-osteoarthropathy (CNO) often fail to heal despite prolonged immobilization with below-knee casting. In a double-blind, placebo-controlled study, these researchers examined the efficacy of rhPTH in reducing time to resolution of CNO and healing of fractures. Patients with diabetes and acute (active) Charcot foot were randomized (double-blind) to either full-length PTH (1-84) or placebo therapy, both in addition to below-knee casting and calcium and vitamin D3 supplementation. The primary outcome was resolution of CNO, defined as a skin foot temperature difference greater than 2°C at 2 consecutive monthly visits. Median time to resolution was 5 months (95 % CI: 4 to 12) in intervention and 6 months (95 % CI: 2 to 9) in control. There was no significant difference in time to resolution between the groups (mixed-effects logistic regression; p = 0.64). The hazard ratio (HR) of resolution was 0.84 (95 % CI: 0.41 to 1.74; p = 0.64), and the odds ratio (OR) of resolution by 12 months was 1.22 (0.90, 1.67; p = 0.20) (intervention versus control). On linear regression analysis, there were no significant differences in the effect of treatment on fracture scores quantitated on magnetic resonance imaging (MRI) scans (coefficient 0.13 [95 % CI: -0.62 to 0.88]; p = 0.73) and on foot and ankle X-rays (coefficient 0.30 [95 % CI: -0.03 to 0.63]; p = 0.07). The authors concluded that they observed no added benefit from PTH (1-84) in achieving earlier resolution of CNO as compared with below-knee casting. Daily intervention with PTH (1-84) did not reduce time to resolution or enhance fracture healing of the active Charcot foot. This study used, for the first time, MRI and X-ray scores, in addition to skin foot temperature, to quantitate resolution and fracture healing, and these new efficacy measures should be considered in further clinical trials in CNO.
The authors stated that this study had several drawbacks. First, annual recruitment was slower than anticipated. Second, during the 2nd year of the trial, the research team was made aware of an unprecedented global shortage of the investigational medicinal product. Nevertheless, with the 48 patients recruited, the study achieved the 30 resolutions called by the power requirement to detect the sought HR of 2.77. Third, withdrawal rate was high; however, missing data analysis indicated the withdrawal mechanism to be “missing at random” since it was not related to skin foot temperature or total MRI fracture score, variables that were significantly associated with the likelihood of clinical resolution by 12 months. Furthermore, findings of the multiple imputation model and the sensitivity analysis were consistent with the findings of the complete-case analysis. This confirmed that the high withdrawal rate did not affect the study results. Fourth, only 73 % in the control group and 65 % in the intervention group were managed in non-removable casts. Nevertheless, this rate was significantly higher than the previously reported rate of the use of non-removable off-loading for the acute Charcot foot in the United Kingdom. (35.4 %). In addition, the type of off-loading was similar between the groups and had no significant effect on resolution.
Han et al (2022) stated that rhPTH promotes tendon-to-bone healing in humans and animals with rotator cuff tear (RCT); however, problems regarding repeated systemic rhPTH injections in humans exist. These researchers examined the effect of topical rhPTH administration using 3-dimensionally (3D)-printed nanofiber sheets on tendon-to-bone healing in a rabbit RCT model compared to that of direct topical rhPTH administration. A total of 80 rabbits were randomly assigned to 5 groups (n = 16 each). To create the chronic RCT model, these investigators induced complete supraspinatus tendon tears in both shoulders and left them untreated for 6 weeks. All transected tendons were repaired in a trans-osseous manner with saline injection in group A, hyaluronic acid (HA) injection in group B, 3D-printed nanofiber sheet fixation in group C, rhPTH and HA injection in group D, and 3D-printed rhPTH- and HA-soaked nanofiber sheet fixation in group E. Genetic (messenger RNA expression evaluation) and histologic evaluations (hematoxylin and eosin and Masson trichrome staining) were carried out in 50 % of the rabbits at 4 weeks post-repair. Genetic, histologic, and biomechanical evaluations (mode of tear and load to failure) were carried out in the remaining rabbits at 12 weeks. For genetic evaluation, group E showed a higher collagen type I alpha 1 expression level than did the other groups (p = 0.008) at 4 weeks. However, its expression level was downregulated, and there was no difference at 12 weeks. For histologic evaluation, group E showed greater collagen fiber continuity, denser collagen fibers, and more mature tendon-to-bone junction than did the other groups (p = 0.001, p = 0.001, and p = 0.003, respectively) at 12 weeks. For biomechanical evaluation, group E showed a higher load-to-failure rate than did the other groups (p < 0.001) at 12 weeks. The authors concluded that 3D-printed rhPTH-soaked nanofiber sheet fixation could promote tendon-to-bone healing of chronic RCT. This was a basic science study using a rabbit model; these findings need to be further investigated in human studies.
Zhang et al (2014) stated that human PTH is known to be effective in the treatment of osteoporosis and reduction of risk of vertebral and non-vertebral fractures; however, its role in the enhancement of human fracture healing is controversial. These investigators conducted a systematic literature review on the use of recombinant PTH in human fracture healing to
evaluate the evidence for recombinant PTH in human fracture healing and
examine if there are notable differences between previous case reports and prospective trials.
These researchers performed a literature search in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews for "teriparatide", "PTH (1-84)", "fracture" and "healing". References of retrieved articles were screened for additional studies, and exclusion criteria were applied. Due to the limited publications on the subject, case reports and case series were included in data analysis. The authors concluded that this review yielded 16 publications on the use of recombinant PTH in human fracture healing with 2 randomized controlled trials (RCTs) with 1 retrospective subgroup analysis. They stated that there were discrepancies in study design in the RCTs and the majority of case reports; additional prospective studies are needed.
Campbell et al (2015) reviewed current literature regarding possible mechanisms and effectiveness for PTH and teriparatide (PTH 1-34, TPTD) to improve the healing process in the setting of various types of fractures. This review focused first on the role of PTH in normal bone. These researchers then discussed mechanisms of normal bone healing as well as delayed and impaired fracture healing. They summarized pertinent animal data and then reviewed human studies utilizing PTH or TPTD for fracture healing. In particular, the authors examined unique situations including osteoporotic fractures, diabetes, stress fractures, delayed or poor healing and combination with bisphosphonate therapy. They concluded that available data indicated there is likely an important role for TPTD and PTH in promoting fracture healing in selected patients, but more clinical trial data are needed.
Ahmed and colleagues (2020) reported the findings of the case of a 35-year-old woman with end-stage renal disease (ESRD) on hemodialysis for 9 years. She was diagnosed with secondary hyperparathyroidism complicated with a brown tumor in the mandible. After medical therapy failed, she underwent total parathyroidectomy (PTX), which was complicated by severe and prolonged hypocalcemia (hungry bone syndrome). Post-surgery, she needed prolonged and frequent intravenous (IV) calcium and a high dose of vitamin D resulting in frequent admission with symptomatic hypocalcemia. Her serum magnesium was noted to be in the normal range. She continued to be hypocalcemic for nearly 8 months post-surgery despite the intensive treatment. Recombinant PTH (teriparatide; 20-mg daily) resulted in normalization of calcium within 2 weeks. The authors concluded that the use of PTH proved to be an effective therapeutic approach in this case. Moreover, these researchers stated that proper pre-operative preparation and subtotal PTX with an adequate dose of vitamin D and calcium supplement may have been a rational option for this case. This was a single-case report.
Furthermore, an UpToDate review on “Hungry bone syndrome following parathyroidectomy in end-stage kidney disease patients” (Berkoben and Quarles, 2021) does not mention recombinant human PTH as a management / therapeutic option.
Management of Medication-Related Osteonecrosis of the Jaw
Taysi and colleagues (2019) stated that treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration . In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient's symptoms under control. These investigators examined a new treatment protocol for medication-related osteonecrosis of the jaw (MRONJ). This treatment protocol consisted of administering hPTH loaded chitosan microspheres that were prepared by ionotropic gelation method and/or the prepared microspheres were suspended in a poloxamer gel. After in-vitro optimization studies, the efficacy of the chosen formulations was evaluated in-vivo studies. Zoledronic acid was administered daily to 48 adult female Sprague-Dawley rats, divided into 4 experimental groups, at a daily concentration of 0.11 mg/kg over 3 weeks to induce the MRONJ model. At the end of this period, maxillary left molar teeth were extracted. In the first group, the subjects received no treatment. In the negative control group, poloxamer hydrogel containing empty microspheres were immediately applied to the soft tissues surrounding the extraction socket. The treatment group-1 was treated with local injections of poloxamer hydrogel containing hPTH. The treatment group-2 was treated with a single local injection of poloxamer hydrogel containing hPTH-loaded chitosan microspheres. Both treatment groups received a total of 7 µg of hPTH at the end of the treatment protocol. The authors concluded that the findings of this study demonstrated successful attenuation of MRONJ via a local drug delivery system combined with hPTH, as opposed to previously attempted treatment strategies. These researchers stated that, to the best of their knowledge, this was the first study to examine the efficacy of local application method with the sustained-release microspheres to attenuate of MRONJ. Moreover, they stated that the limitations of the study included small sample size and the lack of analysis with immunohistochemistry technique; and future research is needed with larger sample size with immunohistochemical observation.
Management of Post-Thyroidectomy Hypoparathyroidism
Edafe and colleagues (2019) noted that post-surgical hypoparathyroidism is a common complication following thyroid surgery. The incidence is likely to increase given the rising trend in the annual number of thyroid surgeries being carried out. Measures to prevent post-thyroidectomy hypoparathyroidism including different surgical techniques and prophylactic calcium and vitamin D supplements have been extensively studied; however, the management of post-thyroidectomy hypoparathyroidism has not been extensively studied. Routine use of calcium and vitamin D supplements in the post-operative period may reduce the risk of symptoms, temporary hypocalcemia and hospital stay. However, this may result in over-treatment and has no effect on long-term hypoparathyroidism. Current recommendations on the management of post-thyroidectomy hypoparathyroidism is based on low-quality evidence. Existing guidelines do not often distinguish between surgical and non-surgical hypoparathyroidism, and transient and long-term disease. In a Cochrane review, these researchers examined the evidence on the use of calcium, vitamin D and rhPTH in the management of post-thyroidectomy hypoparathyroidism. Furthermore, they highlighted deficiencies in the current literature and stimulated further work in this field. These investigators searched CENTRAL, Medline, PubMed, Embase as well as ICTRP Search Portal and ClinicalTrials.gov. The date of the last search for all data-bases was December 17, 2018 (except Embase, which was last searched on December 21, 2017). No language restrictions were applied. They planned to include RCTs or controlled clinical trials (CCTs) examining the effects of calcium, vitamin D or rhPTH in individuals with temporary and long-term post-thyroidectomy hypoparathyroidism. Two review authors independently screened titles, abstracts and full texts for relevance. Data-base searches yielded a total of 1751 records. These investigators retrieved potentially relevant full texts and excluded articles on the following basis: not a RCT or CCT; intervention, comparator or both did not match pre-specified criteria; non-surgical causes of hypoparathyroidism, and studies on prevention. None of the articles was eligible for inclusion in the systematic review. The authors concluded that the findings of this systematic review highlighted a gap in the current literature and the lack of high-quality evidence in the management of post-thyroidectomy temporary and long-term hypoparathyroidism. They stated that further research focusing on clinically relevant outcomes is needed to examine the effects of current treatments in the management of temporary and long-term post-thyroidectomy hypocalcemia.
Swami and associates (2017) noted that advanced breast cancer is frequently associated with skeletal metastases and accelerated bone loss. Recombinant PTH [teriparatide, PTH(1-34)] is the first anabolic agent approved in the US for treatment of osteoporosis. While signaling through the PTH receptor in the osteoblast lineage regulates bone marrow hematopoietic niches, the effects of anabolic PTH on the skeletal metastatic niche are unknown. These researchers demonstrated, using orthotopic and intra-tibial models of 4T1 murine and MDA-MB-231 human breast cancer tumors, that anabolic PTH decreases both tumor engraftment and the incidence of spontaneous skeletal metastasis in mice. Micro-computed tomography and histomorphometric analyses revealed that PTH increased bone volume and reduced tumor engraftment and volume. Trans-well migration assays with murine and human breast cancer cells revealed that PTH altered the gene expression profile of the metastatic niche, in particular VCAM-1, to inhibit recruitment of cancer cells. While PTH did not affect growth or migration of the primary tumor, it elicited several changes in the tumor gene expression profile resulting in a less metastatic phenotype. The authors concluded that PTH treatment in mice altered the bone microenvironment, resulting in decreased cancer cell engraftment, reduced incidence of metastases, preservation of bone micro-architecture and prolonged survival. They stated that anabolic PTH clearly warrants further investigation in preventing breast cancer metastasis.
Gou et al (2022) noted that although widely used in clinical practice, vertebral augmentation procedure (VAP) for osteoporotic vertebral compression fracture (OVCF) is not supported. Recently, the effect of rhPTH has been paid great attention for its effectiveness in anti-osteoporosis and bone union. In a retrospective study, these researchers examined the outcome of rhPTH on acute OVCF and compared it with VAP to clarify its therapeutic advantages. This trial included 71 acute OVCF patients from January 2015 to March 2020: 22 received rhPTH treatment (rhPTH group) and 49 underwent VAP (VAP group). The rhPTH group comprised 15 women and 7 men with an average of 76.18 years, and the VAP group comprised 35 women and 14 men with an average of 73.63 years. The thoracic/lumbar vertebrae were 14/8 in the rhPTH group and 29/20 in the VAP group. The average follow-up period was 14.05 months in the rhPTH group and 13.82 months in the VAP group. The 2 groups were evaluated regarding the visual analog score (VAS), Oswestry Disability Index (ODI), OVCF bone union, bone mineral density (BMD), kyphotic angle (KA), anterior and posterior border height (ABH and PBH, respectively), adverse events (AEs) and the health-related quality of life (HR-QOL) assessed by short form-36 health survey scores (SF-36). Categorical variables were analyzed by Chi-square test and continuous variables between groups were analyzed by independent samples t-test or Mann-Whitney U test according to the normality. During the follow-up, the VAS was significantly lower in the rhPTH group than in the VAP group at month 3 (0.39 ± 0.6 versus 0.68 ± 0.651) (p = 0.047), month 6 (0.45 ± 0.60 versus 2.18 ± 1.22) (p < 0.001), and month 12 (0.45 ± 0.60 versus 2.43 ± 1.49) (p < 0.001). At month 12, the ODI was significantly lower in the rhPTH group (18.59 ± 3.33 %) than in the VAP group (28.93 ± 16.71 %) (p < 0.001). Bone bridge was detected on sagittal computed tomography images of all fractured vertebrae in the rhPTH group. The BMD was significantly higher in the rhPTH group (87.66 ± 5.91 Hounsfield units [HU]) than in the VAP group (68.15 ± 11.32HU) (p < 0.001). There were no significant differences in the changes in KA, ABH, and PBH between groups (all p > 0.05). The incidence of new OVCF was significantly lower in the rhPTH group than in the VAP group (p = 0.042). All scores of SF-36 were significantly higher in the rhPTH group than in the VAP group (all p < 0.05). The authors concluded that in acute OVCF patients, rhPTH was better than VAP in increasing spinal BMD to promote OVCF healing, reduced new OVCF, and improve back pain, physical ability, and HR-QOL.
These researchers stated that this trial had several drawbacks. First, this study showed the clinical outcomes of rhPTH for acute OVCF, especially in boosting OVCF union; however, multi-centric randomized trials are needed for future studies. Second, although vital for early treatment, these investigators only focused on patients with acute OVCF in this study, further investigations are needed to examine the effectiveness of rhPTH on subacute and chronic OVCF. Third, high-density bone cement within the vertebral bodies affects the evaluation of bone bridge. These researchers did not examine the fracture union of the affected vertebrae in the VAP group. Furthermore, the subsequent anti-osteoporosis therapy with other anti-osteoporotic medications should also be considered in the future.
Treatment of Osteoporosis
Farahmand and colleagues (2016) stated that osteoporosis in men is an important public health problem with more than 1 million cases in Germany. Although osteoporotic fractures have a much higher mortality in men than in women, male patients are still under-diagnosed and under-treated. These investigators reviewed the epidemiology of male osteoporosis and current treatment situation, pathophysiological aspects at the hormonal level, risk factors, diagnostic work-up and therapeutic options. They provided an overview of data concerning male osteoporosis, recommendations for diagnostic work-up and presentation of the study situation on pharmaceutical therapies. As risk factors for osteoporosis are present in 50 to 70 % of male patients, a detailed patient history is necessary for assessment of the risk factors. Radiological imaging of the spine is primarily recommended to identify individuals with prevalent vertebral fractures, as approximately 10 % of men over the age of 50 years have suffered a vertebral fracture. Laboratory testing of relevant parameters helps to rule out other metabolic bone diseases. In Germany, specific medications available for the treatment of male osteoporosis comprise the active vitamin D analog alfacalcidol, the oral bisphosphonates alendronate and risedronate, the intravenous bisphosphonate zoledronic acid, the anti-receptor activator of NF-κB ligand (RANKL) antibody denosumab, which can be given as intravenous injection and strontium ranelate, a drug with a complex mode of action. Teriparatide, a recombinant form of the 34 N-terminal amino acid sequence of PTH is the only anabolic agent approved for male osteoporosis. The authors concluded that osteoporosis in men is increasingly being recognized as an important public health problem and affected patients need to be adequately diagnosed and treated. Nowadays, a broad spectrum of well-proven therapeutic options with different modes of action allow individual treatment strategies for male osteoporosis patients.
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Khan MI, Waguespack SG, Hu MI. Medical management of postsurgical hypoparathyroidism. Endocr Pract. 2011;17(Suppl 1):18-25.
Linglart A, Rothenbuhler A. From synthesis to replacement of parathyroid hormone. Lancet Diabetes Endocrinol. 2013;1(4):260-261.
Mannstadt M, Clarke BL, Vokes T, et al. Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): A double-blind, placebo-controlled, randomised, phase 3 study. Lancet Diabetes Endocrinol. 2013;1(4):275-283.
NPS Pharmaceuticals, Inc. FDA approves Natpara (parathyroid hormone) for injection as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. Press Release. Bedminster, NJ: NPS Pharma; January 23, 2015.
NPS Pharmaceuticals, Inc. Natpara (parathyroid hormone) for injection. Recombinant human parathyroid hormone. BLA 12551. Risk Evaluation and Mitigation Strategy (REMS). Initial REMS Approval: 01/2015. Bedminster, NJ: NPS Pharmaceuticals; January 2015.
NPS Pharmaceuticals, Inc. Natpara (parathyroid hormone) for injection, for subcutaneous use. Prescribing Information. Bedminster, NJ: NPS Pharmaceuticals; January 2015.
Petrova NL, Donaldson NK, Bates M, et al. Effect of recombinant human parathyroid hormone (1-84) on resolution of active Charcot neuro-osteoarthropathy in diabetes: A randomized, double-blind, placebo-controlled study. Diabetes Care. 2021;44(7):1613-1621.
Shire-NPS Pharmaceuticals, Inc. Natpara (parathyroid hormone) for injection, for subcutaneous use. Prescribing Information. Lexington, MA: Shire-NPS: revised April 2022.
Swami S, Johnson J, Bettinson LA, et al. Prevention of breast cancer skeletal metastases with parathyroid hormone. JCI Insight. 2017;2(17):e90874.
Tay YD, Tabacco G, Cusano NE, et al. Therapy of hypoparathyroidism with rhPTH(1-84): A prospective eight year investigation of efficacy and safety. J Clin Endocrinol Metab. 2019;104(11):5601-5610.
Taysi AE, Cevher E, Sessevmez M, et al. The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ. Braz Oral Res. 2019;33:e086.
U.S. Food and Drug Administration (FDA). FDA approves Natpara to control low blood calcium levels in patients with hypoparathyroidism. FDA News Release. Silver Spring, MD: FDA: January 23, 2015.
Vokes TJ, Mannstadt M, Levine MA, et al. Recombinant human parathyroid hormone effect on health-related quality of life in adults with chronic hypoparathyroidism. J Clin Endocrinol Metab. 2018;103(2):722-731.
Zhang D, Potty A, Vyas P, Lane J. The role of recombinant PTH in human fracture healing: A systematic review. J Orthop Trauma. 2014;28(1):57-62
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Star Craft II
This post might seem like white noise to some of my regular audience. I figured I'd post it anyhow to see what happens. Basically there's nothing to do over the winter besides plan next year's gardens, and research assorted topics. In between this though I take little breaks finding various ways to relax.
One such way is to play computer games such as "Star Craft II: Wings of Liberty." It's a popular game, and actually won best Real Time Strategy of 2010 from a lot of reviewers. It was even a contender for Game of the Year but didn't quite make it. (I couldn't tell you who won.) One of the reasons it's so popular is the multiplayer aspect. And it's one of the main games used in "Professional Gaming," yes people and teams are actually sponsored by companies to play this game and compete in torments. What's more bizarre is there's actually a slow growing second industry inspired by this one called Online Gaming Commentator. Here is an example.
These games are not for everyone. If you're not as proficient with a computer this isn't a game for you. If you can handle this kind of game though you'll find it to be one of the more engaging and balanced out there.
For those looking for something a little deeper the single player campaign has you covered. The story revolves around the Terran race (humans) and probably with good reason. They're they most accessible to their target audience. They're the perfect race to show off some amazing story telling that I don't think I can describe well enough so I'll let the game's official release trailer do that for me.
The score is excellent and worthy of any Hollywood summer block buster. Supposedly they went to three different composers, one for each race. What's unclear is if all three were used for this one game. Star Craft II has two expansion packs coming that will feature stories revolving around the other two races, Zerg and Protoss. The Protoss scare the bejesus out of me and the Zerg don't communicate with a series of grunts.
What could they possibly do for the Zerg? Not to spoil anything but at the end they lose their only speaking character. In Star Craft one they were voiced by gelatinous blobs that formed the hive mind as well as the Overmind, who was a floating eye ball being held up by some vanes. The only thing I can think of that could mix up the action is allow these beings to possess various Zerg units to incorporate some action into the dialog scenes.
The Protoss should be easier for them to do. Their units don't have mouths but we've herd them speak before. They're more ethereal beings. They're all about the crystals and religion. Star Craft II is actually a blessing to this race because in Star Craft I their base sort of looked like they bought it at Toys R Us. The graphic overhaul has updated this look.
Labels: Game, Video
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Interstitial Lung Disease Pipeline Insight Report | 120+ Companies and 120+ Drugs
DelveInsight’s, “Interstitial Lung Diseases Pipeline Insight 2023” report provides comprehensive insights about 120+ companies and 120+ pipeline drugs in the Interstitial Lung Disease pipeline landscape. It covers the Interstitial Lung Diseases pipeline drug profiles, including Interstitial Lung Diseases clinical trial and nonclinical stage products. It also covers the Interstitial Lung Diseases pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Key takeaways from the Interstitial Lung Diseases Pipeline Report
DelveInsight’s interstitial lung disease Pipeline report depicts a robust space with 120+ active players working to develop 120 + pipeline therapies for interstitial lung disease treatment.
The leading Interstitial Lung Diseases Companies include AdAlta, Bristol-Myers Squibb, aTyr Pharma, Avalyn Pharmaceuticals, Beijing Continent Pharmaceutical, Regend Therapeutics, Reata Pharmaceuticals, FibroGen, PureTech Health, Bellerophon Pulse Technologies, OncoArendi Therapeutics, LTT Bio-Pharma, EmphyCorp, Genentech, Cudetaxestat, Boehringer Ingelheim, Prometheus Biosciences, HEC Pharm, Bayer, Insmed, Bristol-Myers Squibb, Avalyn Pharma, PureTech Health, Roche, Ark Biosciences, Novartis, Lung Therapeutics, Horizon, MediciNova, Endeavor BioMedicines, Pliant Therapeutics, Kadmon Pharmaceuticals, GenKyoTex, Taiho Pharmaceutical,Syndax Pharmaceuticals, Metagone Biotech, Galecto Biotech, CSL Behring and AstraZeneca, and others.
Promising Interstitial Lung Diseases Pipeline Therapies include AD-214, Abatacept, ATYR1923, Pirfenidone inhalation, RO-0220912, Lung stem cells, Bardoxolone methyl, Pamrevlumab, Deupirfenidone, INOpulse, OATD 01, LT 0011, GDC 3280, Blade Therapeutics, BI 1015550, PRA 023, Yifenidone, Riociguat, Treprostinil Palmitil, BMS 986278, Pirfenidone inhalation, Deupirfenidone, Zinpentraxin alfa, AK 3280, Ianalumab, LTI-03, HZN-825, Tipelukast, ENV-101, PLN-74809, KD025, Setanaxib, TAS-115,Axatilimab, MG-S-2525, GB0139,CSL312 and Saracatinib, others.
The Interstitial Lung Diseases Companies and academics are working to assess challenges and seek opportunities that could influence R&D Interstitial Lung Disease. The Interstitial Lung Diseases pipeline therapies under development are focused on novel approaches to treat/improve Interstitial Lung Disease.
Discover the recent breakthroughs and advances in the interstitial lung disease drug treatment landscape @ Interstitial Lung Disease Pipeline Outlook
Recent Developmental Activities in the Interstitial Lung Disease Treatment Landscape
In March 2022, Blade Therapeutics, announced new data from preclinical studies that highlight the differentiating characteristics of cudetaxestat, an investigational non-competitive autotaxin inhibitor in clinical development for IPF and other fibrotic diseases. Cudetaxestat (BLD-0409), a non-competitive, reversible inhibitor of autotaxin, has demonstrated direct anti-fibrotic activity and differentiating preclinical and biochemical characteristics which support the potential for a treatment profile in lung and liver fibrosis. Cudetaxestat has been granted orphan drug designations in the treatment of IPF and systemic sclerosis.
In February 2022, Boehringer Ingelheim announced that the US Food and Drug Administration (FDA) granted Breakthrough Therapy Designation to its novel investigational therapy, BI 1015550, for the treatment of idiopathic pulmonary fibrosis (IPF). BI 1015550 is an oral, phosphodiesterase 4B (PDE4B) inhibitor with the potential to address both pulmonary fibrosis – an irreversible scarring of lung tissue that negatively impacts lung function and inflammation associated with progressive fibrosing interstitial lung diseases (ILDs)
In February 2022, Endeavor BioMedicines, announced the completion of a $101 million Series B financing, led by Ally Bridge Group and Avidity Partners.Proceeds will support the advancement of Endeavor’s pipeline programs, including ENV-101 (taladegib), a small molecule inhibitor of the PTCH1 receptor in the Hedgehog signaling pathway for the treatment of cancer and idiopathic pulmonary fibrosis (IPF), as well as ENV-201, a potentially best-in-class small molecule inhibitor of ULK1/2 for the treatment of KRAS-driven cancers
In January 2022, Horizon Therapeutics announced the first patient has enrolled in a Phase IIb pivotal trial to evaluate its development-stage medicine HZN-825, a lysophosphatidic acid receptor 1 (LPAR1) antagonist to treat people with IPF, the most common interstitial lung disease. HZN-825 is an oral selective LPAR1 antagonist that has shown early signs of clinical impact in systemic sclerosis. LPAR1 signaling has been implicated in fibrosis and inflammation, and preclinical and clinical evidence support the antifibrotic potential of LPAR1 antagonism across multiple organ systems, including both lung and skin.
In November 2021, Biotech Acquisition Company and Blade Therapeutics, Inc. entered into a definitive merger agreement. Upon the closing of the transaction, which is anticipated to occur in the first quarter of 2022, the combined company will be renamed Blade Biotherapeutics, Inc
In October 2021, Agomab Therapeutics announced that it entered into a definitive agreement under which it will acquire Origo Biopharma S.L., a Spanish clinical-stage biotechnology company developing organ-restricted small molecule drug candidates targeting the transforming growth factor beta (TGF-β) pathway for the treatment of fibrosis-related disorders.
In July 2021, FibroGen announced that FG-3019, the Company’s human monoclonal antibody against connective tissue growth factor (CTGF), has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) for the treatment of idiopathic pulmonary fibrosis (IPF)
In February 2021, ImmunoMet Therapeutics announced that the US Food and Drug Administration (FDA) cleared the Investigational New Drug (IND) application for IM156, an investigational Protein Complex 1 inhibitor, being evaluated for idiopathic pulmonary fibrosis (IPF) as well as granting it Orphan Drug Designation.
Interstitial Lung Disease Overview
Interstitial lung disease (diffused parenchymal diseases) are a heterogeneous group of disorders characterized by fibrosis (scarring) of the lungs. These are classified on the basis of histopathological, radiologic and clinical parameters. The classification system used to describe interstitial lung disease categorizes conditions based on clinical, histopathological or radiologic parameters. Clinical classification groups ILD by its causes to help differentiate exogenous or endogenous factors. Interstitial lung disease diseases without identifiable causes get grouped under idiopathic/primary which uses the histopathological and radiological approach as its infrastructure. Many of the subsets of the disease are of unknown etiology. Regardless, they all ultimately share the same manner of development. The morphological changes seen histologically result from a sequence of inflammation within the parenchyma, which is the portion of the lung involved in gas exchange (the alveoli, the alveolar ducts, and the bronchioles). This compartment is the habitat to various proteins and pro-fibrotic elements. These proteins, after repeated cycles of activation, give rise to accumulation of connective tissue. The trigger can be a known agent that deposited within the lung tissues. In some cases, the fibrosis arises spontaneously.
Find out more about interstitial lung disease clinical trials and pipeline therapies @ Interstitial Lung Disease Treatment Landscape
Interstitial Lung Disease Emerging Drugs
DWN12088: Daewoong Pharmaceutical
DWN12088 is an investigational therapy for idiopathic pulmonary fibrosis (IPF), that has shown the promising anti-fibrotic properties and appeared to be safe and well-tolerated in a recently-completed Phase I clinical trial that enrolled healthy volunteers. DWN12088 is an investigational IPF therapy that limits the body’s ability to produce collagen by preventing an enzyme called glutamyl-prolyl-tRNA synthetase from adding proline to the protein’s sequence. The FDA designated it as an orphan drug for idiopathic pulmonary fibrosis (IPF) in 2019. The drug is currently in Phase II stage of clinical trial evaluation to treat IPF.
LYT-100: PureTech
LYT-100 is PureTech’s most advanced wholly-owned therapeutic candidate. A deuterated form of pirfenidone, an approved anti-inflammatory and anti-fibrotic drug, LYT-100 is being advanced for the potential treatment of conditions involving inflammation and fibrosis, including lung disease (e.g., IPF and potentially other PF-ILDs and Long COVID respiratory complications and related sequelae), and disorders of lymphatic flow, such as lymphedema. PureTech completed a Phase 1 multiple ascending dose and food effect study evaluating LYT-100 in healthy volunteers and found it to be well-tolerated at all doses tested. PureTech is evaluating LYT-100 in a Phase 2 trial as a potential treatment for Long COVID respiratory complications and related sequelae as well as in a Phase 2a proof-of-concept study in patients with breast cancer-related, upper limb secondary lymphedema. PureTech is also advancing LYT-100 for the treatment of IPF and potentially other PF-ILDs and is planning registration-enabling studies. PureTech also expects to initiate a Phase 2 dose-ranging trial of LYT-100 in patients with IPF in the first half of 2022.
BMS-986278: Bristol-Myers Squibb
BMS 986278, a lysophosphatidic acid receptor antagonist (LPA1) is being developed by Bristol-Myers Squibb, the treatment of idiopathic pulmonary fibrosis. BMS-986278 is a potent and complete antagonist of LPA action at LPA1-mediated Gi, Gq, G12, and β-arrestin signaling pathways in both cells heterologously expressing human LPA1 and in primary human lung fibroblasts. Currently, it is in Phase II stage of clinical trial evaluation.
Interstitial Lung Disease Therapeutic Assessment
There are approx. 120+ key companies which are developing the therapies Interstitial Lung Disease. The companies which have their Interstitial Lung Disease drug candidates in the most advanced stage, i.e phase III include Pfizer.
Learn more about the novel and emerging interstitial lung disease therapies @ Interstitial Lung Disease Ongoing Clinical Trials Analysis
Interstitial Lung Disease Segmentation
The Interstitial Lung Disease Pipeline report proffers an integral view of the interstitial lung disease emerging novel therapies segmented by Stage, Product Type, Molecule Type, Mechanism of Action, and Route of Administration.
Scope of the Interstitial Lung Disease Pipeline Report
Coverage- Global
Interstitial Lung Disease Companies- AdAlta, Bristol-Myers Squibb, aTyr Pharma, Avalyn Pharmaceuticals, Beijing Continent Pharmaceutical, Regend Therapeutics, Reata Pharmaceuticals, FibroGen, PureTech Health, Bellerophon Pulse Technologies, OncoArendi Therapeutics, LTT Bio-Pharma, EmphyCorp, Genentech, Cudetaxestat, Boehringer Ingelheim, Prometheus Biosciences, HEC Pharm, Bayer, Insmed, Bristol-Myers Squibb, Avalyn Pharma, PureTech Health, Roche, Ark Biosciences, Novartis, Lung Therapeutics, Horizon, MediciNova, Endeavor BioMedicines, Pliant Therapeutics, Kadmon Pharmaceuticals, GenKyoTex, Taiho Pharmaceutical,Syndax Pharmaceuticals, Metagone Biotech, Galecto Biotech, CSL Behring and AstraZeneca, and others.
Interstitial Lung Disease Pipeline Therapies- AD-214, Abatacept, ATYR1923, Pirfenidone inhalation, RO-0220912, Lung stem cells, Bardoxolone methyl, Pamrevlumab, Deupirfenidone, INOpulse, OATD 01, LT 0011, GDC 3280, Blade Therapeutics, BI 1015550, PRA 023, Yifenidone, Riociguat, Treprostinil Palmitil, BMS 986278, Pirfenidone inhalation, Deupirfenidone, Zinpentraxin alfa, AK 3280, Ianalumab, LTI-03, HZN-825, Tipelukast, ENV-101, PLN-74809, KD025, Setanaxib, TAS-115,Axatilimab, MG-S-2525, GB0139,CSL312 and Saracatinib, others.
Interstitial Lung Disease Segmentation: Phases, Molecule Type, Mechanism of Action, Product Type
Interstitial Lung Disease Executive Summary
Interstitial Lung Disease: Overview
Interstitial Lung Disease Pipeline Therapeutics
Interstitial Lung Disease– DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
RO-0220912: Roche
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Daratumumab: Janssen Biotech
Early Stage Products (Phase I)
BGB 16673: BeiGene
Preclinical Stage Products
Drug name: Company name
Inactive Products
Interstitial Lung Disease Key Companies
Interstitial Lung Disease Key Products
Interstitial Lung Disease- Unmet Needs
Interstitial Lung Disease- Market Drivers and Barriers
Interstitial Lung Disease- Future Perspectives and Conclusion
Interstitial Lung Disease Analyst Views
Current Treatment Scenario and Emerging Therapies:
How many companies are developing Interstitial Lung Disease drugs?
How many Interstitial Lung Disease drugs are developed by each company?
How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Interstitial Lung Disease?
What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Interstitial Lung Disease therapeutics?
What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
What are the clinical studies going on for Interstitial Lung Disease and their status?
What are the key designations that have been granted to the emerging drugs?
Dive deep into rich insights into new interstitial lung disease drugs, visit @ Interstitial Lung Disease Key Companies and Pipeline Drugs
DelveInsight is a Business Consulting and Market research company, providing expert business solutions for the healthcare domain and offering quintessential advisory services in the areas of R&D, Strategy Formulation, Operations, Competitive Intelligence, Competitive Landscaping, and Mergers & Acquisitions.
Contact Person: Yash Bhardwaj
Website: https://www.delveinsight.com/
Revolutionize The Trading Strategy with NeuralNet bot: The AI-Powered Trading Bot
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Christmas in July 2018: Jason Morris
from 1977's Emmet Otter's Jug-Band Christmas
Christmas in July 2018: Jason Morris-Holiday Film Reviews
Links: https://holidayfilmreviews.blogspot.com/
https://www.facebook.com/holidayfilmreviews/
1) Name your favorite Henson's Muppet Christmas program and why.
Emmet Otter’s Jug Band Christmas. The characters are very lovable and beautifully designed, Paul Williams’ songs are catchy and fun, and the story is touching. I’ve watched this every Christmas since I first stumbled on it in 1980.
2) Which decade produced the bulk of your favorite Christmas entertainment?
The 1960s, because that’s the decade that gave us the “holy trinity” of Christmas specials: Rudolph, Charlie Brown and The Grinch.
from 1951's A Christmas Carol
3) Imagine the entertainment behind your ideal Christmas Eve dinner. Name the appetizer, entré, and dessert.
Appetizer: A Charlie Brown Christmas
Entre: A Christmas Carol (1951) with Alastair Sim
Dessert: A Christmas Story
4) What Christmas episode, special or movie doesn't exist--that you wish did? Feel free to get creative.
The Rockford Files was an event in my house every Friday night when I was growing up, my parents and I loved the series. I wish they’d made a Christmas episode, if for no other reason than it would give me an excuse to watch the series every December. We could’ve seen Jim and Rocky celebrating, putting up a little tree in the trailer, or Angel Martin working on some scheme that involved a Santa suit.
from 1965's A Charlie Brown Christmas
5) If one Christmas movie, special or episode was to be selected for a time capsule to opened in 1,000 years, which title do you think should be included?
A Charlie Brown Christmas, because it’s still the best Christmas special more than fifty years after its debut. Its message still rings true today, Vince Guaraldi’s music still sounds amazing and it’s also very funny (I still laugh heartily every time I see Snoopy dance on Schroeder’s piano!).
Joanna August 7, 2018 at 8:52 PM
The Rockford Files Christmas!? why didn't I think of that? What a wonderful suggestion. I can see Isaac Hayes as Gandolph Fitch wearing a Santa hat cocked to one side, harassing Jim "Rockfish." Great responses Jason :D
Answer Time #8
Ask Me Anything: 2018
Christmas in July 2018: RECAP
Christmas in July 2018: Jim Fanning
DVD Dress Update--Part 2
Christmas in July 2018: Tom Beiter
Christmas in July 2018: D.X. Ferris
Christmas in July 2018: Jennifer Lundgren
Christmas in July 2018: Craig
Christmas in July 2018: John D.
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In Gananoque Ontario, Gananoque Ontario Events October 18th, 2022
Fall in Yoga Flow ???
Turn inwards and Let go of what no longer serves in a gentle yet strengthening breath led hatha yoga flow.
Bring a blanket and fuzzy socks ? for a yummy and cozy savasana ??
6:00pm-7:00pm Tuesday October 25th
Please bring a yoga mat, comfy blanket and socks ?
St. Andrews Presbyterian church ⛪️ side door on Sydenham St into Gracey Hall $15.00 prepay by etransfer or drop in with cash.
Please arrive 10 minutes early to get settled and sign your waiver.
Date : October 25, 2022 from 6 to 7pm
Event location : St. Andrew’s Presbyterian Church, Gananoque | Gananoque
Contact : Wellness with Michelle
Gananoque Lions Club Cruise
When: Saturday, June 6, 2015 – from 9:00am to 5:00pm Where: Gananoque Town Park Bring out your classic or unique car, truck or motorcycle. Judging starts at noon. 24 car and truck classes and 5 motorcycle classes. Two winners each class and dash plaques given to the first 150 entrants Admission Details:
Zoom – Ukulele Jam Sessions
Wednesdays at 1:00 p.m. – 3 p.m. Come jam with us! E-mail gplp@bellnet.ca for login and password code. Date : Wednesday, June 24, 2020 Event location : Gananoque, Ontario Contact : Website: http://www.gananoquelibrary.ca/
Explore GANANOQUE ONTARIO
Gananoque is a beautiful town located in the heart of the 1000 Islands. Take a tour of the Thousand Islands with the Gananoque Boat Lines. Learn about the history of this fabulous area by visiting the Arthur Child Heritage Museum. Catch a breathtaking view of the 1000 Islands and the the St. Lawrence River from the 1000 Islands Skydeck. There are wonderful shops and restaurants around Gananoque making the downtown area a fun place to visit. There is always something to do in Gananoque and there are several attractions throughout the year such as the Poker Run and Power Boating Extravaganza, Jammin' in the Islands Music Fest and the 1000 Islands Music Fest. The 1000 Islands Playhouse is also another famous attractions in Gananoque. Gananoque provides fantastic fishing, boating, golfing, historical landmarks, biking, trails for walking, sightseeing and much more.
If you have never been to Gananoque or you are a returning visitor and would like to find out about places to stay, stores to shop at and things to do, visit our Business Directory.
For a list of upcoming events happening in Gananoque, visit our events calendar or click on events for a detailed description. Join the Gananoque Communinty Group and participate in discussions about Gananoque. Feel free to contact us with any questions or if you would like to be a part of our website.
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Mall Cops Go 51/50 on May 27th
51/50 Mall Cop, a new comedy directed by Palme d'Or winner David Greenspan, on May 27, 2014.
The film features an all-star cast with Jennifer Morrison (ABC’s Once Upon a Time, House M.D., Star Trek), Kathleen Robertson (Beverly Hills 90219, Starz’s Boss, I Am Sam), Nick Searcy (FX’s Justified, Cast Away, Moneyball) and Derek Cecil (Cinemax's Banshee, Parker, HBO’s Treme).
Set in a quintessential American town, 51/50 Mall Cop follows Frank (Cecil), a somewhat heroic mall cop injured in the line of duty. A late night botched burglary sends Frank into a frenzy and his heroic actions leave Frank one arm short and jobless. Replaced by a sexy punk rocker Donna (Kathleen Robertson), Frank decides to solve the crime, win the girl of his dreams and get his old job back! With the help of his nerdy best friend Chris (Jennifer Morrison), the ultra-strange White Wedding (Nick Searcy), and his sexy replacement – follow Frank’s adventure in this hilarious tale about love, limbs, a One-Armed Hero and Billy Idol!
The impressive soundtrack, featuring White Wedding by Billy Idol and Run Runaway by Slade, coupled with off-the-wall moments and quirky characters, unveils the hilarious battle for ultimate power and a severed arm.
The film will be available in rental stores, retail chains, TV, including 180 million homes on Video On Demand nationwide. Additional details, including the trailer preview, can be found at: http://indicanpictures.com/indicanpictures/5150-mall-cop/
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End of preview.