safetyreportid,receivedate,serious,seriousnessdeath,seriousnesslifethreatening,seriousnesshospitalization,patientagegroup,patientsex,patientweight,patientonsetage,patientonsetageunit,reaction,drug,outcome,reportercountry,qualification,transmissiondate,therapeutic_area
17221356,2020-01-01,1,,,,,1,,66,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Pulmonary oedema, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Faeces soft, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Bacterial infection, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Crying, 'reactionoutcome': 1}]","[{'drugcharacterization': 1, 'medicinalproduct': OTEZLA, 'drugauthorizationnumb': 205437, 'drugstructuredosagenumb': 30, 'drugstructuredosageunit': 003, 'drugdosagetext': 60 MILLIGRAM, 'drugadministrationroute': 048, 'drugindication': PSORIASIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 4, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': APREMILAST}, 'openfda': {'application_number': [NDA205437], 'brand_name': [OTEZLA], 'generic_name': [APREMILAST], 'manufacturer_name': ['Amgen, Inc'], 'product_ndc': [55513-137, 55513-369, 55513-485, 55513-497, 55513-508, 55513-996, 55513-519, 55513-516], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [ORAL], 'substance_name': [APREMILAST], 'rxcui': [1492732, 1492738, 1492740, 1492742, 1492744, 1492746, 1492747, 1492748, 1605454, 1605455, 2682429, 2682430, 2682431, 2682432, 2723448, 2723452, 2724366, 2724367], 'spl_id': [d869faaf-a5ad-4b12-b427-06587d17787e], 'spl_set_id': [f6b1f516-4972-4d82-bced-113e47b41cc5], 'package_ndc': [55513-137-60, 55513-137-95, 55513-369-55, 55513-485-95, 55513-485-96, 55513-497-60, 55513-508-55, 55513-518-04, 55513-497-51, 55513-996-96, 55513-996-95, 55513-497-23, 55513-519-30, 55513-516-41], 'unii': [UP7QBP99PN], 'nui': [N0000182961, N0000182960], 'pharm_class_epc': ['Phosphodiesterase 4 Inhibitor [EPC]'], 'pharm_class_moa': ['Phosphodiesterase 4 Inhibitors [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 2, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 804, 'drugdosageform': TABLETS, 'drugstartdateformat': 102, 'drugstartdate': 20191126, 'drugrecurreadministration': 3, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': OTEZLA, 'drugauthorizationnumb': 205437, 'drugstructuredosagenumb': 30, 'drugstructuredosageunit': 003, 'drugdosagetext': 60 MILLIGRAM, 'drugadministrationroute': 048, 'drugindication': PSORIATIC ARTHROPATHY, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 4, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': APREMILAST}, 'openfda': {'application_number': [NDA205437], 'brand_name': [OTEZLA], 'generic_name': [APREMILAST], 'manufacturer_name': ['Amgen, Inc'], 'product_ndc': [55513-137, 55513-369, 55513-485, 55513-497, 55513-508, 55513-996, 55513-519, 55513-516], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [ORAL], 'substance_name': [APREMILAST], 'rxcui': [1492732, 1492738, 1492740, 1492742, 1492744, 1492746, 1492747, 1492748, 1605454, 1605455, 2682429, 2682430, 2682431, 2682432, 2723448, 2723452, 2724366, 2724367], 'spl_id': [d869faaf-a5ad-4b12-b427-06587d17787e], 'spl_set_id': [f6b1f516-4972-4d82-bced-113e47b41cc5], 'package_ndc': [55513-137-60, 55513-137-95, 55513-369-55, 55513-485-95, 55513-485-96, 55513-497-60, 55513-508-55, 55513-518-04, 55513-497-51, 55513-996-96, 55513-996-95, 55513-497-23, 55513-519-30, 55513-516-41], 'unii': [UP7QBP99PN], 'nui': [N0000182961, N0000182960], 'pharm_class_epc': ['Phosphodiesterase 4 Inhibitor [EPC]'], 'pharm_class_moa': ['Phosphodiesterase 4 Inhibitors [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 2, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 804, 'drugdosageform': TABLETS, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': 3, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,US,1,2020-04-09,Immunology / Rheumatology
17221372,2020-01-01,1,,,,5,2,74,59,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Product use issue, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Conjunctivitis, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Blindness transient, 'reactionoutcome': 1}]","[{'drugcharacterization': 1, 'medicinalproduct': REUQUINOL, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 400, 'drugstructuredosageunit': 003, 'drugdosagetext': '400 MG, 1X/DAY', 'drugadministrationroute': 065, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': 610, 'drugenddate': 201909, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': HYDROXYCHLOROQUINE SULFATE}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 804, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 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17221470,2020-01-01,1,,,1,,1,,61,801,"[{'reactionmeddraversionpt': 23.1, 'reactionmeddrapt': Lung neoplasm malignant, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 23.1, 'reactionmeddrapt': Bronchial carcinoma, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 23.1, 'reactionmeddrapt': Squamous cell carcinoma of lung, 'reactionoutcome': 3}]","[{'drugcharacterization': 1, 'medicinalproduct': ROACTEMRA, 'drugauthorizationnumb': 125276, 'drugstructuredosagenumb': 8, 'drugstructuredosageunit': 007, 'drugdosagetext': 8 MG/KG, 'drugadministrationroute': 042, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': 610, 'drugenddate': 201507, 'actiondrug': 6, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': TOCILIZUMAB}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': 602, 'drugstartdate': 2010, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': ASKED BUT UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': DOLIPRANE, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': NULL, 'drugadministrationroute': 048, 'drugindication': GAIT DISTURBANCE, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 5, 'drugadditional': 3, 'activesubstance': {'activesubstancename': ACETAMINOPHEN}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': ASKED BUT UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': IMETH, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 10, 'drugstructuredosageunit': 003, 'drugdosagetext': 10 MG, 'drugadministrationroute': 048, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': 610, 'drugenddate': 201604, 'actiondrug': 1, 'drugadditional': 2, 'activesubstance': {'activesubstancename': METHOTREXATE SODIUM}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': 602, 'drugstartdate': 2003, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': ASKED BUT UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': ROACTEMRA, 'drugauthorizationnumb': 125472, 'drugstructuredosagenumb': 162, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 058, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': 610, 'drugenddate': 201604, 'actiondrug': 1, 'drugadditional': 2, 'activesubstance': {'activesubstancename': TOCILIZUMAB}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': 610, 'drugstartdate': 201507, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': ASKED BUT UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': SPECIAFOLDINE, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 10, 'drugstructuredosageunit': 003, 'drugdosagetext': 10 MG, 'drugadministrationroute': 048, 'drugindication': PROPHYLAXIS, 'drugenddateformat': 610, 'drugenddate': 201604, 'actiondrug': 1, 'drugadditional': 2, 'activesubstance': {'activesubstancename': FOLIC ACID}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': TABLET, 'drugstartdateformat': 602, 'drugstartdate': 2003, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,FR,3,2020-11-02,Immunology / Rheumatology
17221473,2020-01-01,1,,,,5,2,,28,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Abortion spontaneous, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNK, 'drugadministrationroute': 065, 'drugindication': PSORIASIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 1, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': UNKNOWN FORMULATION, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,GB,5,2020-04-09,Immunology / Rheumatology
17221484,2020-01-01,1,,,,,2,,,,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Leukopenia, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': METHOTREXATE., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNK, 'drugadministrationroute': 065, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': METHOTREXATE}, 'openfda': {'application_number': [ANDA210454, NDA011719, NDA212479, ANDA040385, ANDA040263, ANDA220225, ANDA040632, ANDA201529, ANDA201749, ANDA081235, NDA205776, NDA208400, ANDA040266, ANDA040843, ANDA207812, ANDA081099, ANDA040716, ANDA089343, ANDA089342, ANDA089341, ANDA089340, ANDA213343, ANDA217552, NDA204824], 'brand_name': [METHOTREXATE, JYLAMVO, TREXALL, RASUVO, XATMEP, OTREXUP], 'generic_name': [METHOTREXATE, METHOTREXATE SODIUM], 'manufacturer_name': 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['Corticosteroid [EPC]'], 'pharm_class_moa': ['Corticosteroid Hormone Receptor Agonists [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,US,2,2020-04-09,Immunology / Rheumatology
17221526,2020-01-01,1,,,1,6,2,78,75,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Memory impairment, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Femur fracture, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Fall, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Dementia Alzheimer^s type, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Dementia, 'reactionoutcome': 3}]","[{'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': 50, 'drugstructuredosageunit': 003, 'drugdosagetext': '50 MILLIGRAM, QWK (WEDNESDAYS)', 'drugadministrationroute': 065, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 4, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,BR,5,2020-04-09,Immunology / Rheumatology
17221532,2020-01-01,1,,1,1,6,2,46,70,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Cardiac arrest, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Blood pressure increased, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Renal colic, 'reactionoutcome': 1}]","[{'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNK, 'drugadministrationroute': 065, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 4, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, 'drugstartdateformat': 602, 'drugstartdate': 2016, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,BR,5,2020-04-09,Immunology / Rheumatology
17221533,2020-01-01,1,,,,5,2,,55,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Ventricular extrasystoles, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Cardiogenic shock, 'reactionoutcome': 2}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Brain natriuretic peptide increased, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Cardiomegaly, 'reactionoutcome': 2}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Inflammatory marker increased, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Blood creatine increased, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Cardiac arrest, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Pulmonary congestion, 'reactionoutcome': 2}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Myocarditis, 'reactionoutcome': 2}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Pulmonary oedema, 'reactionoutcome': 2}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Ventricular fibrillation, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Troponin increased, 'reactionoutcome': 6}]","[{'drugcharacterization': 2, 'medicinalproduct': MELOXICAM., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNK, 'drugadministrationroute': NULL, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': MELOXICAM}, 'openfda': {'application_number': [ANDA077921, NDA021530, NDA218395, ANDA077920, ANDA217579, ANDA211398, ANDA077944, ANDA077918, ANDA077929, ANDA209487, ANDA077927, ANDA077882, NDA217593, ANDA078008], 'brand_name': [MELOXICAM, ZYBIC, XIFYRM, QAMZOVA], 'generic_name': [MELOXICAM], 'manufacturer_name': [Zydus Pharmaceuticals USA Inc., Quallent Pharmaceuticals Health 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Pharmaceuticals USA LLC, 'MARC GLASSMAN, INC.', Blueberri Inc., CVS HEALTH CORP, 'CVS Pharmacy,Inc', FAMILY DOLLAR SERVICES INC, Procter & Gamble Manufactura S de RL de CV, BJWC, 'Wal-Mart Stores, Inc.', 'PAI Holdings, LLC dba PAI Pharma', COSTCO WHOLESALE COMPANY, Family Dollar, JHK DBA American Safety & First Aid, Amazon, WAL-MART STORES INC., JHK Inc dba American Safety & First Aid, Wildman Business Group, 'QUALITY CHOICE (Chain drug Marketing Assoiciation)', Geri-Care Pharmaceutical Corp, 'Cardinal Health 110, LLC.', Walgreens Company, 'CitraGen Pharmaceuticals, Inc.', Hy-Vee Inc, WALGREEN COMPANY, Thompson, H-E-B, FSA STORE INC., 'MARC GLASSMAN, INC', BM Private Limited, 'Anhui Jiuhe Health Industry Co., Ltd', 'Geiss, Destin Dunn'], 'product_ndc': [67091-358, 72476-132, 30142-268, 50332-0151, 85828-903, 11822-3510, 30142-300, 82585-303, 55319-927, 51316-053, 79481-0093, 11673-568, 36800-489, 42507-195, 41250-553, 47682-285, 63868-701, 41250-232, 79481-1150, 50804-179, 83698-591, 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Fougera & Co. a division of Fougera Pharmaceuticals, LLC', 'Encube Ethicals, Inc.', Kroger Company, 'Long Grove Pharmaceuticals, LLC', 'Saptalis Pharmaceuticals, LLC.', Apotex Corp., Amazon.com Services LLC, Amneal Pharmaceuticals LLC, Topco Associates LLC, H E B, Padagis Israel Pharmaceuticals Ltd, NorthStar Rx LLC, PureTek Corporation, 'CARDINAL HEALTH 110, LLC. DBA LEADER 70000', Safeway, 'Cintex Services, LLC', Hikma Pharmaceuticals USA Inc., MICRO LABS LIMITED, Walgreen Company, Strides Pharma Science Limited, Mylan Institutional LLC, L. 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22.1, 'reactionmeddrapt': Synovitis, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Nail cuticle fissure, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Arthralgia, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Nail bed bleeding, 'reactionoutcome': 1}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Antinuclear antibody increased, 'reactionoutcome': 1}]","[{'drugcharacterization': 1, 'medicinalproduct': AMGEVITA, 'drugauthorizationnumb': 761024, 'drugstructuredosagenumb': 40, 'drugstructuredosageunit': 003, 'drugdosagetext': '40 MILLIGRAM, QD', 'drugadministrationroute': 058, 'drugindication': CROHN^S DISEASE, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 5, 'drugadditional': 3, 'activesubstance': {'activesubstancename': ADALIMUMAB}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 804, 'drugdosageform': SOLUTION 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17221772,2020-01-01,1,,,,,2,,69,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Hepatic enzyme increased, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Skin reaction, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Thyroid disorder, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Hypersensitivity, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Synovitis, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Bronchitis, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug hypersensitivity, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Glaucoma, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Pneumonia, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Vomiting, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug intolerance, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Diverticulitis, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug ineffective, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Colitis microscopic, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Hypertension, 'reactionoutcome': 3}]","[{'drugcharacterization': 1, 'medicinalproduct': ORENCIA, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': NULL, 'drugadministrationroute': 065, 'drugindication': PRODUCT USED FOR UNKNOWN INDICATION, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 5, 'drugadditional': 3, 'activesubstance': {'activesubstancename': ABATACEPT}, 'openfda': {'application_number': [BLA125118], 'brand_name': [ORENCIA], 'generic_name': [ABATACEPT], 'manufacturer_name': ['E.R. 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17221785,2020-01-01,1,,,,,2,74.91,62,801,"[{'reactionmeddraversionpt': 23.0, 'reactionmeddrapt': Hand fracture, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 23.0, 'reactionmeddrapt': Pruritus, 'reactionoutcome': 2}, {'reactionmeddraversionpt': 23.0, 'reactionmeddrapt': Herpes zoster, 'reactionoutcome': 2}]","[{'drugcharacterization': 1, 'medicinalproduct': ACTEMRA, 'drugauthorizationnumb': 125276, 'drugstructuredosagenumb': 620, 'drugstructuredosageunit': 003, 'drugdosagetext': 'DATE OF TREATMENT: 14/JUN/2018, 28/NOV/2018', 'drugadministrationroute': 042, 'drugindication': NULL, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 5, 'drugadditional': 3, 'activesubstance': {'activesubstancename': TOCILIZUMAB}, 'openfda': {'application_number': [BLA125276, BLA125472], 'brand_name': [ACTEMRA], 'generic_name': [TOCILIZUMAB], 'manufacturer_name': ['Genentech, Inc.'], 'product_ndc': [50242-135, 50242-136, 50242-137, 50242-138, 50242-143], 'product_type': [HUMAN PRESCRIPTION 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17221794,2020-01-01,1,,,,,2,,33,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Therapeutic product effect incomplete, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Pharyngeal oedema, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Therapeutic product effect decreased, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Rheumatoid arthritis, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Swelling face, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Swollen tongue, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug hypersensitivity, 'reactionoutcome': 3}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug ineffective, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': LEFLUNOMIDE., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 20, 'drugstructuredosageunit': 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HYDROCORTISONE], 'manufacturer_name': [TRIFECTA PHARMACEUTICALS USA LLC, 'Dolgencorp, LLC', Rite Aid Corporation, 'BalmRx, LLC', Unifirst First Aid Corporation, HARRIS TEETER LLC, 'Sun Pharmaceutical Industries, Inc.', AmerisourceBergen, Publix Super Markets Inc, 'Chattem, Inc.', Walgreen Company, 'Shopko Stores Operating Co., LLC', Nantong Health & Beyond Hygienic Products Inc., LEADER, The Kroger Co, ProStat First Aid, BluePoint Laboratories, Topco Associates LLC, Strides Pharma Inc., 'Redmont Pharmaceuticals, LLC', Safeway, Padagis Israel Pharmaceuticals Ltd, 'Meijer, Inc.', VIADERMA DISTRIBUTION INC, Allure Labs Inc., RITE AID CORPORATION, Front Pharmaceutical PLC, 'Chartwell RX, LLC.', Person and Covey, OPMX LLC, Balassa Laboratories Inc., HyVee Inc, 'FOURSTAR GROUP USA, INC.', Army & Air Force Exchange Service, American Sales Company, 'Tai Guk Pharm. Co., Ltd.', Veridian Healthcare, United Exchange Corp., 'New World Imports, Inc', 'United Natural Foods, Inc. dba UNFI', Three Nations Corp, BJWC, ASTONEA LABS PRIVATE LIMITED, Strategic Sourcing Services LLC, 'Geri-Care Pharmaceuticals, Corp', Water-Jel Technologies, 'Fourstar Group USA, Inc', Amazon.com Services LLC, 'Encube Ethicals, Inc.', Trifecta Pharmaceuticals Usa Llc, 'Zhejiang Jingwei Pharmaceutical Co., Ltd.', HART Health, Kroger Company, Pharmacy Value Alliance LLC, 'DLC Laboratories, Inc', 'Sam\'s West Inc', VIVE HEALTH LLC, Shield Line LLC, CVS Pharmacy, Aurobindo Pharma Limited, Eywa Pharma Inc, AKRON PHARMA INC, PureTek Corporation, 'Weeks & Leo Co., Inc.', H E B, Unipack LLC, Trifecta Pharmaceuticals USA, Crown Laboratories, 'Zhejiang Jingwei Pharmaceutic Al Co., Ltd.', 'ANI Pharmaceuticals, Inc.', ALLIED TRADE LINK LLC, Aldermed Inc., Wal-Mart Stores Inc, Insight Pharmaceuticals LLC, Henry Schein, Spa de Soleil, Pharmadel LLC, 'Eton Pharmaceuticals, Inc.', Click Industries LLC, 'Chartwell RX, LLC', Amneal Pharmaceuticals of New York LLC, Chain Drug Marketing Association Inc., 'Chain Drug Marketing Association, Inc.', Twin Med LLC, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc, 'Ana-Cool, LLC', 'E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC', CVS, Strides Pharma Science Limited, 'CVS Pharmacy, Inc.', Productos Zapotol Corp, Clinical Therapeutic Solutions, 'WINCO FOODS, LLC', Absolut Skin Incorporated, Thompson, The Great Atlantic & Pacific Tea Company, Walgreens, 'Lovely Skin, Inc.', L. Perrigo Company, WalMart, 'OAKTREE PRODUCTS, INC.', 'FRED\'S, INC.', Cardinal Health 110 dba LEADER, Wildman Business Group, 'DR. MARDER SKINCARE, LLC', 'Energique, Inc.', Sheffield Pharmaceuticals LLC, Cardinal Health, 'RENU LABORATORIES, LLC', 'DLC Laboratories, Inc.', Dolgencorp Inc, 'Deseret Biologicals, Inc.', 'Salix Pharmaceuticals, Inc', 'Oncora Pharma, LLC', 'Premier Brands of America, Inc.', Rite Aid, Wal-Mart Stores Inc., STRATEGIC SOURCING SERVICES LLC, Kramer Laboratories, J&A Digital Inc., Universal Distribution Center LLC, Allegis Holdings LLC, Trifluent Pharma LLC, Kenvue Brands LLC, Crane Safety LLC, Haleon US Holdings LLC, 'Family Dollar Stores, Inc', 'THERAPLEX, LLC', 'Renu Laboratories, LLC', 'Rooftop Consumer Health, Inc.', GERI-GENTLE CORPORATION, Walgreens Company, Rugby Laboratories, JHK Inc dba American Safety & First Aid, Unishield, Derm Ventures LLC, 'ViaDerma Distribution, Inc.', 'ELIXIR HEALTHCARE USA, LLC.', 'Actavis Pharma, Inc.', 'CVS PHARMACY, INC', Walgreens Co., 'Topiderm, Inc.', NeilMed Pharmaceuticals Inc, 'A2A Integrated Pharmaceuticals, LLC', Pharmacia & Upjohn Company LLC, Meijer Distribution Inc, WeCare Products LLC, Mission Pharmacal Company, CVS Health, 'DISCOUNT DRUG MART, INC.', Westlake Pharma LLC, Mylan Pharmaceuticals Inc., Claridei Laboratories, 'Melaleuca, Inc.', 'Natureplex, LLC', 'Guangdong Quadrant Ecological Technology Co., Ltd.', AMERISOURCE BERGEN, Reckitt Benckiser LLC, Beiersdorf Inc, Neilmed Pharmaceuticals Inc., TARGET Corporation, Target Corporation, Vi Medical Products Inc., 'Safetec of America, Inc.', 'CP Skin Health Group, Inc.', Vege Labs LLC., 'Fourstar Group USA, Inc.', 'Leading Pharma, LLC', FSA Store Inc., Chartwell RX LLC, Costco Wholesale Company, Meijer Distribution Inc., Medrock Pharmacy LLC, Cintas Corporation, 'OL PHARMA TECH,LLC', Alumier Labs, 'Pharmaceutical Specialties, Inc.', Clinical Formula LLC, Dynarex Corporation, 'L\'Oreal USA Products Inc.', Walgreen Co., PHARMACY CHOICE INC, Mericon Industries, 'Wal-Mart Stores, Inc.', 'Medline Industries, LP'], 'product_ndc': [69396-149, 55910-646, 11822-2099, 85529-204, 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17221814,2020-01-01,1,,,1,,2,64.8,56,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Agranulocytosis, 'reactionoutcome': 1}]","[{'drugcharacterization': 2, 'medicinalproduct': FAMPYRA, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 10, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 048, 'drugindication': MULTIPLE SCLEROSIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': DALFAMPRIDINE}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 12, 'drugintervaldosagedefinition': 805, 'drugdosageform': NULL, 'drugstartdateformat': 602, 'drugstartdate': 2013, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': 'IMETH [METHOTREXATE]', 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 10, 'drugstructuredosageunit': 003, 'drugdosagetext': 10 MG/0.4 ML, 'drugadministrationroute': 058, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': 102, 'drugenddate': 20191114, 'actiondrug': 1, 'drugadditional': 1, 'activesubstance': {'activesubstancename': METHOTREXATE}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': NULL, 'drugstartdateformat': 602, 'drugstartdate': 2013, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': MABTHERA, 'drugauthorizationnumb': 103705, 'drugstructuredosagenumb': 2000, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 042, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 4, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': RITUXIMAB}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': SOLUTION FOR INFUSION, 'drugstartdateformat': 602, 'drugstartdate': 2016, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,FR,2,2020-04-09,Immunology / Rheumatology
17221820,2020-01-01,1,,,,,1,,,,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Stomatitis, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Weight decreased, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug ineffective, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Rheumatoid arthritis, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug intolerance, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Feeding disorder, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': METHOTREXATE., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 25, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 058, 'drugindication': NULL, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 5, 'drugadditional': 3, 'activesubstance': {'activesubstancename': METHOTREXATE}, 'openfda': 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17221834,2020-01-01,1,,,,5,2,,58,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Rectal cancer, 'reactionoutcome': 6}]","[{'drugcharacterization': 2, 'medicinalproduct': PARACETAMOL, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': IF NEEDED, 'drugadministrationroute': NULL, 'drugindication': NULL, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ACETAMINOPHEN}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 2, 'medicinalproduct': 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Perrigo Company, Spirit Pharmaceutical LLC, 'Meijer, Inc.', TWIN MED LLC, 'Better Living Brands, LLC', 'Wal-Mart Stores, Inc.', Haleon US Holdings LLC, 'SAM\'S WEST INC', 'Dr. Reddy\'s Laboratories Limited', Unifirst First Aid Corporation, 'Chartwell RX, LLC', CVS Pharmacy, 'TIME CAP LABORATORIES,INC', Kenvue Brands LLC, Aurohealth LLC, AptaPharma Inc., Chain Drug Marketing Association Inc., Uline, 'Breeden Brothers, LLC', FSA STORE INC., Amerisource Bergen, Target Corporation, CVS, Amazon.com Services LLC, Advagen Pharma Ltd., WALGREEN COMPANY, Cintas Corporation, 'Sun Pharmaceutical Industries, Inc.', 'EQUATE (Wal-Mart Stores, Inc.) 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International, Inc.', 'Retail Business Services, LLC', Geri-Care Pharmaceutical Corp, Dolgencorp Inc, Cumberland Pharmaceuticals Inc., 'Family Dollar (FAMILY WELLNESS)', 'Westminster Pharmaceuticals, LLC', 'Chain Drug Marketing Association, Inc.', VALU MERCHANDISERS COMPANY, 'TIME CAP LABORATORIES, INC.', 'FSA Store Inc. (Caring Mills)', Spirit Pharmaceuticals LLC, 'WR Group, Inc.', 'BETTER LIVING BRANDS, LLC', 'Rugby Laboratories, Inc.', HART Health, Henry Schein Inc., MARKSANS PHARMA LIMITED, 'Topco Associates, LLC', WALGREENS, Publix Super Markets Inc, 'SOLA Pharmaceuticals, LLC', Meijer Distribution Inc, 'Best Choice (Valu Merchandisers Company)', TOPCO ASSOCIATES LLC, Trifecta Pharmaceuticals USA LLC, AMERISOURCE BERGEN, RITE AID, 'PAI Holdings, LLC dba PAI Pharma', 'TOP CARE (Topco Associates LLC)', 'Marc Glassman, Inc.', Chain Drug Consortium, RITE AID CORPORATION, HEB, Amneal Pharmaceuticals LLC, 'Humanwell PuraCap Pharmaceuticals (Wuhan) Co., Ltd', 'Pharmaceutical Associates, Inc.', Amneal Pharmaceuticals NY LLC, KROGER COMPANY, 'Lil\' Drug Store Products, Inc.', PURACAP PHARMACEUTICAL LLC, Thompson Safety, CHAIN DRUG MARKETING ASSOCIATION INC., 'FSA Store Inc. (Caring Mill)', PLD Acquisitions LLC DBA Avma Pharma Solutions, 'Cardinal Health 110, LLC. 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Inc., 'Chain Drug Consortium, LLC', JHK Inc dba American Safety & First Aid, 'Harris Teeter, LLC', 'Demoulas Super Markets, Inc', 'ADVANCED FIRST AID, INC.', 'Sam\'s West Inc', Family Dollar Services Inc, DISCOUNT DRUG MART, Unifirst First Aid, 'RANDOB LABS,LTD. DBA CROSSINGWELL CONSUMER HEALTH', AMERIFOODS TRADING COMPANY, Contract Pharmacal Corp., 'SPIRIT PHARMACEUTICALS,LLC', 'DOLGENCORP, LLC', Bi-Mart, 'SKYA HEALTH, LLC', Family Dollar, 'Gobrands, Inc', 'TARO PHARMACEUTICALS U.S.A., INC.', 'CHAIN DRUG MARKETING ASSOCIATION, INC.', Provision Medical Products, CVS Pharmacy.Inc., Health Pharma USA LLC, 'Strategic Sourcing Services, LLC', 'Conney Safety Products, LLC', 'Lil\' Drug Store products, Inc.', 'Sam\'s West, Inc.', COSTCO WHOLESALE CORPORATION, WALGREENS CO., 'AAA Pharmaceutical, Inc.', 'EQUATE (WAL-MART STORES, INC.)', 'EXELAN PHARMACEUTICALS, INC.', HYVEE INC, 'Salado Sales, Inc.', 'Actavis Pharma, Inc.', 'Florida Pharmaceutical Products, LLC', 7-Eleven, BI-MART, 'Meijer Distribution, Inc.', AAFES/Your Military Exchanges, 'DISCOUNT DRUG MART, INC.', McKesson Medical-Surgical, OPMX LLC, PUBLIX SUPER MARKETS INC, 'Medline industries, LP', 'Whole Foods Market, INC.', 'Care One (Retail Business Services, LLC.)', New World Imports, Kesin Pharma Corporation, SPIRIT PHARMACEUTICALS LLC, 'Wal-Mart Stores, Inc', 'CVS PHARMACY, INC.', 'Cardinal Health (Leader) 70000', Reliable 1 Laboratories LLC, 'Jones Healthcare Group - Packaging Services, Inc', 'Granules USA, Inc.', HealthLife of USA LLC, CARDINAL HEALTH, Better Living Brands LLC, 'DOLGENCORP, INC.'], 'product_ndc': [55910-518, 41520-495, 70692-175, 11822-3307, 55910-847, 42507-660, 63941-128, 72036-212, 30142-497, 70000-0263, 51013-319, 54162-941, 0113-7366, 68210-0026, 79481-0419, 55681-401, 21130-216, 49035-635, 0573-0179, 68196-601, 55111-682, 55111-683, 55111-684, 47682-600, 47682-614, 47682-608, 47682-609, 47682-602, 47682-610, 42507-461, 0573-0170, 0573-0174, 0573-0171, 0573-0290, 0573-0207, 0573-0232, 62135-400, 62135-401, 62135-402, 69842-329, 41520-685, 49483-611, 49483-612, 69842-706, 50580-184, 58602-008, 76281-128, 83324-013, 69790-609, 69790-709, 70729-291, 81522-119, 24385-647, 11673-741, 51316-914, 72288-604, 72888-479, 0363-0221, 11822-4461, 51013-103, 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'pharm_class_cs': ['Antibodies, Monoclonal [CS]'], 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': SOLUTION FOR INJECTION, 'drugstartdateformat': 102, 'drugstartdate': 20150722, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,NL,1,2020-04-09,Immunology / Rheumatology
17221845,2020-01-01,1,,,,6,2,68,75,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Injection site pruritus, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Injection site erythema, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Femur fracture, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Fall, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': 50, 'drugstructuredosageunit': 003, 'drugdosagetext': '50 MILLIGRAM, QWK', 'drugadministrationroute': 065, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 4, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, 'drugstartdateformat': 610, 'drugstartdate': 201503, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 2, 'medicinalproduct': RIVOTRIL, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNK, 'drugadministrationroute': NULL, 'drugindication': SLEEP DISORDER, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': CLONAZEPAM}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,BR,5,2020-04-09,Immunology / Rheumatology
17221846,2020-01-01,1,,,,6,2,,72,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Gait inability, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Rheumatoid arthritis, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Loss of personal independence in daily activities, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Gait disturbance, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Feeling abnormal, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': 'UNK UNK, QWK', 'drugadministrationroute': 065, 'drugindication': PRODUCT USED FOR UNKNOWN INDICATION, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 1, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': UNKNOWN FORMULATION, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,BR,5,2020-04-09,Immunology / Rheumatology
17221847,2020-01-01,1,1,,,,1,,16,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug resistance, 'reactionoutcome': 5}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Cytomegalovirus colitis, 'reactionoutcome': 5}]","[{'drugcharacterization': 1, 'medicinalproduct': PREDNISONE., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': NULL, 'drugadministrationroute': 065, 'drugindication': GLOMERULONEPHRITIS MEMBRANOUS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 5, 'drugadditional': 3, 'activesubstance': {'activesubstancename': PREDNISONE}, 'openfda': {'application_number': [ANDA215246, ANDA080292, ANDA088832, ANDA083677, ANDA040584, ANDA040581, ANDA040256, ANDA040392, ANDA210785, ANDA080352, ANDA211495, ANDA215671, ANDA219477, ANDA088703, ANDA084275, ANDA208412, ANDA211496, ANDA213385, ANDA215672, ANDA212629, ANDA213386, ANDA211575, ANDA080356, ANDA085162, ANDA085161], 'brand_name': 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'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 2, 'medicinalproduct': SPIRIVA, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNK, 'drugadministrationroute': NULL, 'drugindication': NULL, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': TIOTROPIUM BROMIDE MONOHYDRATE}, 'openfda': {'application_number': [NDA021395], 'brand_name': [SPIRIVA HANDIHALER], 'generic_name': [TIOTROPIUM BROMIDE], 'manufacturer_name': ['Boehringer Ingelheim Pharmaceuticals, Inc.'], 'product_ndc': [0597-0075], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [ORAL, 'RESPIRATORY (INHALATION)'], 'substance_name': [TIOTROPIUM BROMIDE MONOHYDRATE], 'rxcui': [485032, 580261], 'spl_id': [94768574-0d3e-46f0-9f75-ab3c9f52857d], 'spl_set_id': [820839ef-e53d-47e8-a3b9-d911ff92e6a9], 'package_ndc': [0597-0075-41, 0597-0075-75, 0597-0075-47], 'unii': [L64SXO195N], 'nui': NULL, 'pharm_class_epc': NULL, 'pharm_class_moa': NULL, 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,BR,5,2020-04-09,Immunology / Rheumatology
17221888,2020-01-01,1,,,1,,2,103,75,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Bronchial carcinoma, 'reactionoutcome': 3}]","[{'drugcharacterization': 1, 'medicinalproduct': ROACTEMRA, 'drugauthorizationnumb': 125276, 'drugstructuredosagenumb': 800, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 042, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': 102, 'drugenddate': 20190815, 'actiondrug': 1, 'drugadditional': 2, 'activesubstance': {'activesubstancename': TOCILIZUMAB}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': SOLUTION FOR INFUSION, 'drugstartdateformat': 102, 'drugstartdate': 20190521, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': UNKNOWN, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,DE,5,2020-04-09,Immunology / Rheumatology
17221894,2020-01-01,1,1,,,,1,,,,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Death, 'reactionoutcome': 5}]","[{'drugcharacterization': 1, 'medicinalproduct': HUMIRA, 'drugauthorizationnumb': 125057, 'drugstructuredosagenumb': 40, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 058, 'drugindication': PSORIASIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 6, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ADALIMUMAB}, 'openfda': {'application_number': [BLA125057], 'brand_name': [HUMIRA], 'generic_name': [ADALIMUMAB], 'manufacturer_name': [Cordavis Limited, AbbVie Inc.], 'product_ndc': [83457-124, 83457-554, 83457-243, 83457-616, 83457-817, 0074-0124, 0074-3799, 0074-4339, 0074-9374, 0074-0243, 0074-0554, 0074-0067, 0074-2540, 0074-1539, 0074-0616, 0074-0817], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': NULL, 'substance_name': NULL, 'rxcui': [797544, 1726844, 1726846, 1872979, 1872980, 1921009, 1921010, 1921016, 1921017, 1921238, 1921240, 727703, 727705, 763564, 763565, 825169, 825170, 1594352, 1594357, 1594358, 1655726, 1655728, 1656703, 1801277, 1801278, 1855523, 1855524, 1855526, 1855527, 1872983, 1872984, 1872985, 1872986, 1873086, 1873087, 1921244, 1921245, 1921467, 1921468, 2531133, 2531134], 'spl_id': [5fe81b1a-cc31-444e-a0f1-1ea4f7334b89, 8bf84b15-6763-41cf-bfa4-bcee9ad4ef9a], 'spl_set_id': [4977567e-3525-44ac-9ff5-f1e74b053950, 608d4f0d-b19f-46d3-749a-7159aa5f933d], 'package_ndc': [83457-554-02, 83457-553-01, 83457-927-01, 83457-124-02, 83457-123-01, 83457-243-02, 83457-242-01, 83457-616-02, 83457-615-01, 83457-817-02, 83457-816-01, 0074-3799-02, 0074-3799-71, 0074-3799-06, 0074-3799-03, 0074-4339-02, 0074-4339-07, 0074-4339-71, 0074-4339-73, 0074-4339-01, 0074-4339-74, 0074-9374-71, 0074-0243-02, 0074-0243-71, 0074-0554-01, 0074-0554-02, 0074-0554-04, 0074-0554-06, 0074-0554-71, 0074-0554-74, 0074-0554-73, 0074-0067-02, 0074-2540-01, 0074-2540-03, 0074-0124-74, 0074-0124-73, 0074-0124-01, 0074-0124-03, 0074-0124-02, 0074-0124-04, 0074-1539-03, 0074-0616-71, 0074-0616-02, 0074-0817-02], 'unii': NULL, 'nui': NULL, 'pharm_class_epc': NULL, 'pharm_class_moa': NULL, 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 2, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION IN PRE-FILLED PEN, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NOT AVAILABLE, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,GB,5,2020-04-09,Immunology / Rheumatology
17221972,2020-01-01,1,,,,5,2,,48,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Device malfunction, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Injection site pain, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Drug dose omission by device, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Rheumatoid arthritis, 'reactionoutcome': 3}]","[{'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': 50, 'drugstructuredosageunit': 003, 'drugdosagetext': '50 MILLIGRAM, QWK', 'drugadministrationroute': 065, 'drugindication': NULL, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 6, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': ENBREL, 'drugauthorizationnumb': 103795, 'drugstructuredosagenumb': 50, 'drugstructuredosageunit': 003, 'drugdosagetext': '50 MILLIGRAM, QWK', 'drugadministrationroute': 065, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 6, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': {'application_number': [BLA103795], 'brand_name': [ENBREL], 'generic_name': [ETANERCEPT], 'manufacturer_name': [Immunex Corporation], 'product_ndc': [58406-010, 58406-425, 58406-021, 58406-032, 58406-044, 58406-055], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ETANERCEPT], 'rxcui': [253014, 261105, 727757, 802652, 809158, 809159, 1653223, 1653225, 2182338, 2182340, 2392140, 2392142], 'spl_id': [de3ee3bd-0047-4365-a4c7-5786521a1649], 'spl_set_id': [a002b40c-097d-47a5-957f-7a7b1807af7f], 'package_ndc': [58406-425-41, 58406-425-34, 58406-424-01, 58406-910-01, 58406-021-01, 58406-021-04, 58406-021-96, 58406-032-01, 58406-032-04, 58406-032-96, 58406-032-90, 58406-010-01, 58406-010-04, 58406-010-96, 58406-044-01, 58406-044-04, 58406-044-96, 58406-044-24, 58406-044-90, 58406-055-01, 58406-055-04, 58406-055-96, 58406-055-90], 'unii': [OP401G7OJC], 'nui': [N0000175610, N0000175451], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,US,1,2020-04-09,Immunology / Rheumatology
17222143,2020-01-01,1,,,,5,2,,,,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Limb injury, 'reactionoutcome': 2}]","[{'drugcharacterization': 2, 'medicinalproduct': LEPICORTINOLO, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 5, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 048, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': PREDNISOLONE}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 804, 'drugdosageform': TABLET, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 2, 'medicinalproduct': OMEPRAZOLE., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': NULL, 'drugadministrationroute': 048, 'drugindication': PROPHYLAXIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': OMEPRAZOLE}, 'openfda': {'application_number': [NDA022032, ANDA079182, ANDA210593, ANDA207891, ANDA075410, ANDA206877, ANDA075757, NDA209400, ANDA206582, ANDA075576, ANDA216096, ANDA091352, ANDA203481, ANDA207740, ANDA076515, ANDA076048, ANDA211732, ANDA204012, ANDA091672, ANDA213201, ANDA078490, ANDA212977, ANDA203270], 'brand_name': [GOOD NEIGHBOR PHARMACY OMEPRAZOLE, OMEPRAZOLE/SODIUM BICARBONATE, KIRKLAND SIGNATURE OMEPRAZOLE, OMEPRAZOLE, FOSTER AND THRIVE OMEPRAZOLE, ACID REDUCER, BERKLEY AND JENSEN OMEPRAZOLE, GOOD NOW OMEPRAZOLE, GOOD SENSE OMEPRAZOLE, BASIC CARE OMEPRAZOLE, UP AND UP OMEPRAZOLE, EQUATE OMEPRAZOLE DELAYED RELEASE ACID REDUCER, DG HEALTH OMEPRAZOLE, TOPCARE OMEPRAZOLE, CAREONE OMEPRAZOLE, EQUALINE OMEPRAZOLE, LEADER OMEPRAZOLE, EQUATE OMEPRAZOLE, DG HEALTH OMPERAZOLE, SIGNATURE CARE OMEPRAZOLE, MEMBERS MARK OMEPRAZOLE, AMAZON BASIC CARE OMEPRAZOLE, RUGBY OMEPRAZOLE, TOPCARE OMEPRAZOLE DELAYED RELEASE, 24 HR OMEPRAZOLE, CARE ONE OMEPRAZOLE, EXCHANGE SELECT OMEPRAZOLE, GOOD SENSE OMEPRAZOLE DELAYED RELEASE], 'generic_name': [OMEPRAZOLE, OMEPRAZOLE MAGNESIUM], 'manufacturer_name': [Amerisource Bergen, Strides Pharma Science Limited, Costco Wholesale Company, 'INNOVUS PHARMACEUTICALS, INC.', OHM LABORATORIES INC., Strategic Sourcing Services LLC, STRATEGIC SOURCING SERVICES LLC, 'GERI-CARE PHARMACEUTICALS, CORP', 'Lannett Company, Inc.', WALGREEN CO., Sandoz Inc, Cardinal Health, 'Chartwell RX, LLC', BJWC, 'CVS Pharmacy, Inc.', HARRIS TEETER, PLD Acquisitions LLC DBA Avma Pharma Solutions, RELIABLE 1 LABORATORIES LLC, DISCOUNT DRUG MART, 'Gobrands, Inc', L. 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(see also Equate)', Chain Drug Marketing Association INC, 'Camber Pharmaceuticals, Inc.', KROGER COMPANY, Living Better Brands LLC, Safeway, Publix Super Markets Inc, 'Sam\'s West Inc', Camber Consumer Care Inc, 'Glenmark Pharmaceuticals Inc., USA', 'Family Dollar (FAMILY WELLNESS)', Allegiant Health, 'Dr. Reddy\'s Laboratories Limited', Kroger Company, NorthStar Rx LLC, BI-MART, 'Family Dollar Stores, LLC', AMERISOURCEBERGEN DRUG CORPORATION, 'CVS Pharamacy, Inc', Bi-Mart, Dr. Reddys Laboratories Inc, Aurobindo Pharma Limited, UP & UP, 'Winco Foods, LLC.', Albertsons Companies, 'Xiromed, LLC', WALMART INC., 7-Eleven, Army & Air Force Exchange Service, Best Choice, 'Rising Pharma Holdings, Inc.', Walgreens, 'Wal-Mart Stores, Inc.'], 'product_ndc': [46122-281, 64380-182, 64380-183, 63981-915, 57483-740, 51660-029, 70677-1275, 70677-1098, 57896-659, 62175-114, 62175-118, 62175-136, 0363-1008, 0781-2785, 0781-2790, 70000-0521, 62135-559, 62135-530, 68391-103, 69842-941, 72036-981, 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17222228,2020-01-01,1,1,2,2,,2,,,,"[{'reactionmeddraversionpt': 26.1, 'reactionmeddrapt': Death, 'reactionoutcome': 5}, {'reactionmeddraversionpt': 26.1, 'reactionmeddrapt': Sinusitis, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': VEDOLIZUMAB, 'drugauthorizationnumb': 125476, 'drugstructuredosagenumb': 300, 'drugstructuredosageunit': 003, 'drugdosagetext': 300 MILLIGRAM, 'drugadministrationroute': 042, 'drugindication': Crohn^s disease, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 6, 'drugadditional': 4, 'activesubstance': {'activesubstancename': VEDOLIZUMAB}, 'openfda': {'application_number': [BLA761133, BLA125476], 'brand_name': [ENTYVIO, ENTYVIO PEN], 'generic_name': [VEDOLIZUMAB], 'manufacturer_name': ['Takeda Pharmaceuticals America, Inc.'], 'product_ndc': [64764-107, 64764-300, 64764-108], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS, INTRAVENOUS], 'substance_name': [VEDOLIZUMAB], 'rxcui': [1538137, 1538142, 2667332, 2667336, 2667339, 2667342], 'spl_id': [266293d6-dd28-4e38-81c2-4f518d95ef5d], 'spl_set_id': [6e94621c-1a95-4af9-98d1-52b9e6f1949c], 'package_ndc': [64764-300-20, 64764-108-20, 64764-108-21, 64764-107-10, 64764-107-11], 'unii': [9RV78Q2002], 'nui': [N0000175775, N0000175774], 'pharm_class_epc': ['Integrin Receptor Antagonist [EPC]'], 'pharm_class_moa': ['Integrin Receptor Antagonists [MoA]'], 'pharm_class_cs': NULL, 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': Powder for solution for infusion, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': Unknown, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,US,5,2024-01-10,Immunology / Rheumatology
17222247,2020-01-01,1,,,,,1,,89,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Urinary tract infection, 'reactionoutcome': 6}, {'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Immunosuppression, 'reactionoutcome': 6}]","[{'drugcharacterization': 1, 'medicinalproduct': BRENZYS, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 50, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 058, 'drugindication': RHEUMATOID ARTHRITIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 1, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': ETANERCEPT}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION, 'drugstartdateformat': 102, 'drugstartdate': 20190111, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,CA,5,2020-04-09,Immunology / Rheumatology
17222248,2020-01-01,1,,,,,2,,34,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Cutaneous leishmaniasis, 'reactionoutcome': 1}]","[{'drugcharacterization': 1, 'medicinalproduct': ADALIMUMAB, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 40, 'drugstructuredosageunit': 003, 'drugdosagetext': '40 MG, UNK', 'drugadministrationroute': 058, 'drugindication': PSORIASIS, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 1, 'drugadditional': 1, 'activesubstance': {'activesubstancename': ADALIMUMAB}, 'openfda': {'application_number': [BLA125057, BLA761219, BLA761071, BLA761154], 'brand_name': [HUMIRA, ADALIMUMAB], 'generic_name': [ADALIMUMAB, ADALIMUMAB-AATY, ADALIMUMAB-ADAZ, ADALIMUMAB-FKJP], 'manufacturer_name': [Cordavis Limited, 'CELLTRION USA, Inc.', AbbVie Inc., Sandoz Inc, Biocon Biologics Inc], 'product_ndc': [83457-124, 83457-554, 83457-243, 83457-616, 83457-817, 72606-022, 72606-040, 72606-041, 0074-0124, 0074-3799, 0074-4339, 0074-9374, 0074-0243, 0074-0554, 0074-0067, 0074-2540, 0074-1539, 0074-0616, 0074-0817, 61314-325, 61314-327, 61314-332, 61314-391, 83257-020, 83257-021, 83257-022], 'product_type': [HUMAN PRESCRIPTION DRUG], 'route': [SUBCUTANEOUS], 'substance_name': [ADALIMUMAB], 'rxcui': [797544, 1726844, 1726846, 1872979, 1872980, 1921009, 1921010, 1921016, 1921017, 1921238, 1921240, 2639651, 2639659, 2668483, 2668485, 2668487, 2668489, 727703, 727705, 763564, 763565, 825169, 825170, 1594352, 1594357, 1594358, 1655726, 1655728, 1656703, 1801277, 1801278, 1855523, 1855524, 1855526, 1855527, 1872983, 1872984, 1872985, 1872986, 1873086, 1873087, 1921244, 1921245, 1921467, 1921468, 2531133, 2531134, 2641644, 2641653, 2641655, 2641660, 2641662, 2640404, 2640412, 2640417], 'spl_id': [5fe81b1a-cc31-444e-a0f1-1ea4f7334b89, 68fa51bf-22b5-4963-bc1c-9be00fb09b2a, 8bf84b15-6763-41cf-bfa4-bcee9ad4ef9a, ae54abc4-e9c5-4c5a-8fa7-968e5ad72050, ce598802-5148-0115-bd4c-fea7dd51fb90], 'spl_set_id': [4977567e-3525-44ac-9ff5-f1e74b053950, c44365e9-d470-4e35-978d-8565a9e3471e, 608d4f0d-b19f-46d3-749a-7159aa5f933d, 3468792f-63ef-4916-8ed1-8214f327d9dd, 5cde907d-6747-0e62-db25-1718ee717fe7], 'package_ndc': [83457-554-02, 83457-553-01, 83457-927-01, 83457-124-02, 83457-123-01, 83457-243-02, 83457-242-01, 83457-616-02, 83457-615-01, 83457-817-02, 83457-816-01, 72606-022-01, 72606-022-02, 72606-022-03, 72606-022-04, 72606-022-05, 72606-022-06, 72606-022-07, 72606-022-08, 72606-022-09, 72606-022-10, 72606-022-11, 72606-022-12, 72606-040-01, 72606-040-02, 72606-040-03, 72606-040-04, 72606-040-05, 72606-040-06, 72606-041-01, 0074-3799-02, 0074-3799-71, 0074-3799-06, 0074-3799-03, 0074-4339-02, 0074-4339-07, 0074-4339-71, 0074-4339-73, 0074-4339-01, 0074-4339-74, 0074-9374-71, 0074-0243-02, 0074-0243-71, 0074-0554-01, 0074-0554-02, 0074-0554-04, 0074-0554-06, 0074-0554-71, 0074-0554-74, 0074-0554-73, 0074-0067-02, 0074-2540-01, 0074-2540-03, 0074-0124-74, 0074-0124-73, 0074-0124-01, 0074-0124-03, 0074-0124-02, 0074-0124-04, 0074-1539-03, 0074-0616-71, 0074-0616-02, 0074-0817-02, 61314-327-64, 61314-327-20, 61314-332-64, 61314-325-20, 61314-391-64, 83257-020-42, 83257-021-42, 83257-022-32], 'unii': [FYS6T7F842], 'nui': [N0000175610, N0000175451, M0001357], 'pharm_class_epc': ['Tumor Necrosis Factor Blocker [EPC]'], 'pharm_class_moa': ['Tumor Necrosis Factor Receptor Blocking Activity [MoA]'], 'pharm_class_cs': ['Antibodies, Monoclonal [CS]'], 'pharm_class_pe': NULL}, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 2, 'drugintervaldosagedefinition': 803, 'drugdosageform': SOLUTION FOR INJECTION, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,ES,3,2020-04-09,Immunology / Rheumatology
17222250,2020-01-01,1,,,1,,1,,35,801,"[{'reactionmeddraversionpt': 22.1, 'reactionmeddrapt': Subileus, 'reactionoutcome': 1}]","[{'drugcharacterization': 1, 'medicinalproduct': FLIXABI, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 10, 'drugstructuredosageunit': 007, 'drugdosagetext': NULL, 'drugadministrationroute': 042, 'drugindication': CROHN^S DISEASE, 'drugenddateformat': 102, 'drugenddate': 20191106, 'actiondrug': 3, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': INFLIXIMAB}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION, 'drugstartdateformat': 102, 'drugstartdate': 20180228, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 2, 'medicinalproduct': IMUREL, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 150, 'drugstructuredosageunit': 003, 'drugdosagetext': NULL, 'drugadministrationroute': 065, 'drugindication': CROHN^S DISEASE, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': AZATHIOPRINE SODIUM}, 'openfda': NULL, 'drugseparatedosagenumb': 1, 'drugintervaldosageunitnumb': 1, 'drugintervaldosagedefinition': 804, 'drugdosageform': NULL, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}, {'drugcharacterization': 1, 'medicinalproduct': FLIXABI, 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': 10, 'drugstructuredosageunit': 007, 'drugdosagetext': NULL, 'drugadministrationroute': 042, 'drugindication': NULL, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': 3, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': INFLIXIMAB}, 'openfda': NULL, 'drugseparatedosagenumb': NULL, 'drugintervaldosageunitnumb': NULL, 'drugintervaldosagedefinition': NULL, 'drugdosageform': POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION, 'drugstartdateformat': NULL, 'drugstartdate': NULL, 'drugrecurreadministration': NULL, 'drugcumulativedosagenumb': NULL, 'drugcumulativedosageunit': NULL, 'drugbatchnumb': NULL, 'drugtreatmentduration': NULL, 'drugtreatmentdurationunit': NULL, 'drugrecurrence': NULL}]",,FR,5,2020-04-09,Immunology / Rheumatology
17222252,2020-01-01,1,,,1,5,1,55,25,801,"[{'reactionmeddraversionpt': 23.0, 'reactionmeddrapt': Pericarditis, 'reactionoutcome': 2}]","[{'drugcharacterization': 2, 'medicinalproduct': PREDNISOLONE., 'drugauthorizationnumb': NULL, 'drugstructuredosagenumb': NULL, 'drugstructuredosageunit': NULL, 'drugdosagetext': UNKNOWN, 'drugadministrationroute': 065, 'drugindication': PRODUCT USED FOR UNKNOWN INDICATION, 'drugenddateformat': NULL, 'drugenddate': NULL, 'actiondrug': NULL, 'drugadditional': NULL, 'activesubstance': {'activesubstancename': PREDNISOLONE}, 'openfda': {'application_number': [ANDA080531, ANDA040571, ANDA215673, ANDA040323, ANDA218083, ANDA040775], 'brand_name': [PREDNISOLONE], 'generic_name': [PREDNISOLONE, PREDNISOLONE ORAL, PREDNISOLONE ORAL SOLUTION], 'manufacturer_name': ['Chartwell RX, LLC', 'PAI Holdings, LLC dba PAI Pharma', Aurobindo Pharma Limited, 'Zhejiang Xianju Pharmaceutical Co., Ltd.', 'Hisun Pharmaceuticals USA, Inc.', 'Lannett Company, Inc.', Heritage 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