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README.md
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---
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{}
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---
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# ATLAS-1: 3D Drug-Treated Cancer Cells
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**ATLAS-1** is a research dataset of single-cell **3D morphologies** captured under different drug treatments.
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It contains **1,500** WM266-4 human melanoma cells embedded in **collagen** and imaged using **oblique-plane light-sheet microscopy**. Each cell is released as a **1024-point point cloud** sampled from a reconstructed **surface mesh**.
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- **Total cells:** 1,500
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- **Classes / conditions:**
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- `nocodazole` (500) — microtubule inhibitor; rounded morphology
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- `blebbistatin` (500) — myosin II inhibitor; elongated/spindle morphology
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- `control` (500) — untreated baseline variability
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- **Representations:** point clouds (1024 pts/cell) and watertight meshes
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- **Intended use:** benchmarking point-cloud models on real biological shapes; studying drug-induced 3D morphology
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> This dataset accompanies the **PointMIL** project (inherently interpretable point-cloud classification via MIL).
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---
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## Dataset Summary
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Cells were segmented, meshed with **marching cubes** (+ Laplacian smoothing), then **uniformly sampled** to 1024 points per cell from the surface mesh. Files are organized by condition with a metadata CSV that holds labels and basic experiment info.
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**Why ATLAS-1?**
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- Real, noisy, heterogeneous 3D cell shapes (not synthetic CAD)
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- Clear treatment effects (rounded vs elongated) for interpretable benchmarks
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- Comes with both **mesh** and **point-cloud** views for flexible pipelines
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---
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## Repository Layout
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