{"query": {"id": "q_0", "content": "Tricuspid valve regurgitation [SEP] Tricuspid valve regurgitation and lithium carbonate toxicity in a newborn infant.", "tokenized_content": [2, 25487, 9509, 20198, 3, 25487, 9509, 20198, 1930, 14330, 17724, 5532, 1922, 43, 12203, 8125, 18, 3]}, "items": [{"id": "p_0", "content": "Tricuspid Valve Insufficiency [SEP] Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25487, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3659, 11887, 2460, 1920, 3659, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 25487, 9509, 18, 3]}]}
{"query": {"id": "q_1", "content": "lithium carbonate [SEP] Tricuspid valve regurgitation and lithium carbonate toxicity in a newborn infant.", "tokenized_content": [2, 14330, 17724, 3, 25487, 9509, 20198, 1930, 14330, 17724, 5532, 1922, 43, 12203, 8125, 18, 3]}, "items": [{"id": "p_1", "content": "Lithium Carbonate [SEP] A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL ", "score": 1, "type": null, "tokenized_content": [2, 14330, 17724, 3, 43, 14330, 7012, 16, 5947, 1966, 43, 9494, 17, 14384, 5899, 18, 14330, 4755, 13714, 1920, 4714, 1927, 24241, 19730, 25368, 1036, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_2", "content": "toxicity [SEP] Tricuspid valve regurgitation and lithium carbonate toxicity in a newborn infant.", "tokenized_content": [2, 5532, 3, 25487, 9509, 20198, 1930, 14330, 17724, 5532, 1922, 43, 12203, 8125, 18, 3]}, "items": [{"id": "p_2", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3", "content": "tricuspid regurgitation [SEP] A newborn with massive tricuspid regurgitation, atrial flutter, congestive heart failure, and a high serum lit", "tokenized_content": [2, 25487, 20198, 3, 43, 12203, 1956, 12944, 25487, 20198, 16, 9224, 2848, 3519, 1915, 16, 20180, 4003, 4574, 16, 1930, 43, 2149, 3256, 4471, 3]}, "items": [{"id": "p_3", "content": "Tricuspid Valve Insufficiency [SEP] Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25487, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3659, 11887, 2460, 1920, 3659, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 25487, 9509, 18, 3]}]}
{"query": {"id": "q_4", "content": "atrial flutter [SEP] A newborn with massive tricuspid regurgitation, atrial flutter, congestive heart failure, and a high serum lithium level is de", "tokenized_content": [2, 9224, 2848, 3519, 1915, 3, 43, 12203, 1956, 12944, 25487, 20198, 16, 9224, 2848, 3519, 1915, 16, 20180, 4003, 4574, 16, 1930, 43, 2149, 3256, 14330, 2237, 1977, 2028, 3]}, "items": [{"id": "p_4", "content": "Atrial Flutter [SEP] Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave", "score": 1, "type": null, "tokenized_content": [2, 9224, 2848, 3519, 1915, 3, 4052, 16, 11499, 9224, 15465, 4189, 2007, 43, 3367, 1927, 8287, 21896, 12382, 1922, 1920, 3659, 20548, 1930, 43, 21747, 4905, 17182, 1031, 5913, 3]}]}
{"query": {"id": "q_5", "content": "congestive heart failure [SEP] A newborn with massive tricuspid regurgitation, atrial flutter, congestive heart failure, and a high serum lithium level is described. This is the first", "tokenized_content": [2, 20180, 4003, 4574, 3, 43, 12203, 1956, 12944, 25487, 20198, 16, 9224, 2848, 3519, 1915, 16, 20180, 4003, 4574, 16, 1930, 43, 2149, 3256, 14330, 2237, 1977, 2910, 18, 2052, 3]}, "items": [{"id": "p_5", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_6", "content": "lithium [SEP] ion, atrial flutter, congestive heart failure, and a high serum lithium level is described. This is the first patient to initially mani", "tokenized_content": [2, 14330, 3, 4755, 16, 9224, 2848, 3519, 1915, 16, 20180, 4003, 4574, 16, 1930, 43, 2149, 3256, 14330, 2237, 1977, 2910, 18, 2052, 1977, 1920, 2561, 2774, 1942, 6370, 2323, 3]}, "items": [{"id": "p_6", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_7", "content": "cardiac disease [SEP] itation and atrial flutter, and the 11th described patient with cardiac disease among infants exposed to lithium compounds in the first trimest", "tokenized_content": [2, 4435, 2573, 3, 2176, 1943, 1930, 9224, 2848, 3519, 1915, 16, 1930, 1920, 2513, 1963, 2910, 2774, 1956, 4435, 2573, 2706, 5969, 4616, 1942, 14330, 4300, 1922, 1920, 2561, 7103, 3]}, "items": [{"id": "p_7", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_8", "content": "Lithium carbonate [SEP] three percent of these infants had tricuspid valve involvement. Lithium carbonate may be a factor in the increasing incidence of congenital heart", "tokenized_content": [2, 14330, 17724, 3, 2559, 3564, 1927, 2144, 5969, 2430, 25487, 9509, 5668, 18, 14330, 17724, 2278, 1998, 43, 2991, 1922, 1920, 3605, 4332, 1927, 9901, 4003, 3]}, "items": [{"id": "p_8", "content": "Lithium Carbonate [SEP] A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL ", "score": 1, "type": null, "tokenized_content": [2, 14330, 17724, 3, 43, 14330, 7012, 16, 5947, 1966, 43, 9494, 17, 14384, 5899, 18, 14330, 4755, 13714, 1920, 4714, 1927, 24241, 19730, 25368, 1036, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_9", "content": "congenital heart disease [SEP] ithium carbonate may be a factor in the increasing incidence of congenital heart disease when taken during early pregnancy. It also causes neurologic de", "tokenized_content": [2, 9901, 4003, 2573, 3, 24737, 2457, 17724, 2278, 1998, 43, 2991, 1922, 1920, 3605, 4332, 1927, 9901, 4003, 2573, 2469, 4208, 2409, 3120, 5284, 18, 2176, 2222, 5092, 14314, 2028, 3]}, "items": [{"id": "p_9", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_10", "content": "neurologic depression [SEP] heart disease when taken during early pregnancy. It also causes neurologic depression, cyanosis, and cardiac arrhythmia when consumed prior to delive", "tokenized_content": [2, 14314, 4621, 3, 4003, 2573, 2469, 4208, 2409, 3120, 5284, 18, 2176, 2222, 5092, 14314, 4621, 16, 26898, 8362, 16, 1930, 4435, 18346, 2469, 10848, 3432, 1942, 2723, 2320, 3]}, "items": [{"id": "p_10", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_11", "content": "cyanosis [SEP] n during early pregnancy. It also causes neurologic depression, cyanosis, and cardiac arrhythmia when consumed prior to delivery.", "tokenized_content": [2, 26898, 8362, 3, 56, 2409, 3120, 5284, 18, 2176, 2222, 5092, 14314, 4621, 16, 26898, 8362, 16, 1930, 4435, 18346, 2469, 10848, 3432, 1942, 4868, 18, 3]}, "items": [{"id": "p_11", "content": "Cyanosis [SEP] A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin ", "score": 1, "type": null, "tokenized_content": [2, 26898, 8362, 3, 43, 2266, 15641, 2014, 25945, 2951, 2863, 18778, 1943, 1927, 1920, 4407, 1930, 27103, 5726, 2810, 1942, 1925, 2760, 1922, 1920, 4351, 1927, 16333, 2432, 1981, 9652, 3]}]}
{"query": {"id": "q_12", "content": "cardiac arrhythmia [SEP]  pregnancy. It also causes neurologic depression, cyanosis, and cardiac arrhythmia when consumed prior to delivery.", "tokenized_content": [2, 4435, 18346, 3, 5284, 18, 2176, 2222, 5092, 14314, 4621, 16, 26898, 8362, 16, 1930, 4435, 18346, 2469, 10848, 3432, 1942, 4868, 18, 3]}, "items": [{"id": "p_12", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_13", "content": "Phenobarbital [SEP] Phenobarbital-induced dyskinesia in a neurologically-impaired child.", "tokenized_content": [2, 3037, 18986, 3, 3037, 18986, 17, 2719, 3890, 26682, 1922, 43, 7605, 1954, 17, 5761, 2748, 18, 3]}, "items": [{"id": "p_13", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_14", "content": "dyskinesia [SEP] Phenobarbital-induced dyskinesia in a neurologically-impaired child.", "tokenized_content": [2, 3890, 26682, 3, 3037, 18986, 17, 2719, 3890, 26682, 1922, 43, 7605, 1954, 17, 5761, 2748, 18, 3]}, "items": [{"id": "p_14", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_15", "content": "neurologically-impaired [SEP] Phenobarbital-induced dyskinesia in a neurologically-impaired child.", "tokenized_content": [2, 7605, 1954, 17, 5761, 3, 3037, 18986, 17, 2719, 3890, 26682, 1922, 43, 7605, 1954, 17, 5761, 2748, 18, 3]}, "items": [{"id": "p_15", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_16", "content": "neurologic impairment [SEP] A 2-year-old child with known neurologic impairment developed a dyskinesia soon after starting phenobarbital therap", "tokenized_content": [2, 14314, 6159, 3, 43, 22, 17, 2476, 17, 4156, 2748, 1956, 3171, 14314, 6159, 3530, 43, 3890, 26682, 12722, 2256, 6801, 3037, 18986, 2709, 3]}, "items": [{"id": "p_16", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_17", "content": "dyskinesia [SEP] A 2-year-old child with known neurologic impairment developed a dyskinesia soon after starting phenobarbital therapy for seizures. Known c", "tokenized_content": [2, 3890, 26682, 3, 43, 22, 17, 2476, 17, 4156, 2748, 1956, 3171, 14314, 6159, 3530, 43, 3890, 26682, 12722, 2256, 6801, 3037, 18986, 3181, 1958, 10060, 18, 3171, 45, 3]}, "items": [{"id": "p_17", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_18", "content": "phenobarbital [SEP] eurologic impairment developed a dyskinesia soon after starting phenobarbital therapy for seizures. Known causes of movement disorders were e", "tokenized_content": [2, 3037, 18986, 3, 20810, 22284, 1935, 6159, 3530, 43, 3890, 26682, 12722, 2256, 6801, 3037, 18986, 3181, 1958, 10060, 18, 3171, 5092, 1927, 5829, 4414, 1985, 47, 3]}, "items": [{"id": "p_18", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_19", "content": "seizures [SEP] oped a dyskinesia soon after starting phenobarbital therapy for seizures. Known causes of movement disorders were eliminated after evalu", "tokenized_content": [2, 10060, 3, 2494, 1919, 43, 3890, 26682, 12722, 2256, 6801, 3037, 18986, 3181, 1958, 10060, 18, 3171, 5092, 1927, 5829, 4414, 1985, 11412, 2256, 2711, 3]}, "items": [{"id": "p_19", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_20", "content": "movement disorders [SEP] er starting phenobarbital therapy for seizures. Known causes of movement disorders were eliminated after evaluation. On repeat challenge with phen", "tokenized_content": [2, 5829, 4414, 3, 2668, 6801, 3037, 18986, 3181, 1958, 10060, 18, 3171, 5092, 1927, 5829, 4414, 1985, 11412, 2256, 4391, 18, 1990, 6865, 6013, 1956, 3037, 3]}, "items": [{"id": "p_20", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_21", "content": "Phenobarbital [SEP] n repeat challenge with phenobarbital, the dyskinesia recurred. Phenobarbital should be added to the list of anticonvulsant drugs that can ca", "tokenized_content": [2, 3037, 18986, 3, 56, 6865, 6013, 1956, 3037, 18986, 16, 1920, 3890, 26682, 4734, 1919, 18, 3037, 18986, 3066, 1998, 4057, 1942, 1920, 6069, 1927, 26572, 2031, 4195, 1988, 2112, 3]}, "items": [{"id": "p_21", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_22", "content": "ammonia [SEP] Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.", "tokenized_content": [2, 14880, 3, 3939, 2840, 1927, 2877, 14880, 2278, 5660, 3662, 17, 2576, 5246, 2564, 1927, 23867, 1935, 2687, 18, 3]}, "items": [{"id": "p_22", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_23", "content": "valproic acid [SEP] nges of blood ammonia may predict short-term adverse effects of valproic acid.", "tokenized_content": [2, 23867, 1935, 2687, 3, 4375, 1918, 1927, 2877, 14880, 2278, 5660, 3662, 17, 2576, 5246, 2564, 1927, 23867, 1935, 2687, 18, 3]}, "items": [{"id": "p_23", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_24", "content": "Valproic acid [SEP] Valproic acid (VPA) was given to 24 epileptic patients who were already being", "tokenized_content": [2, 23867, 1935, 2687, 3, 23867, 1935, 2687, 12, 19703, 13, 1982, 3258, 1942, 2686, 16304, 2132, 2746, 1985, 6064, 3301, 3]}, "items": [{"id": "p_24", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_25", "content": "VPA [SEP] Valproic acid (VPA) was given to 24 epileptic patients who were already being trea", "tokenized_content": [2, 19703, 3, 23867, 1935, 2687, 12, 19703, 13, 1982, 3258, 1942, 2686, 16304, 2132, 2746, 1985, 6064, 3301, 2171, 1019, 3]}, "items": [{"id": "p_25", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_26", "content": "epileptic [SEP] Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepilepti", "tokenized_content": [2, 16304, 3, 23867, 1935, 2687, 12, 19703, 13, 1982, 3258, 1942, 2686, 16304, 2132, 2746, 1985, 6064, 3301, 2868, 1956, 2303, 27140, 2410, 1033, 3]}, "items": [{"id": "p_26", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_27", "content": "Ammonia [SEP] tered, and venous blood was sampled at 0, 1, 2, 3, and 4 hours. Ammonia (NH3) was higher in patients who, during continuous therapy, co", "tokenized_content": [2, 14880, 3, 6005, 1919, 16, 1930, 8562, 2877, 1982, 8783, 2019, 20, 16, 21, 16, 22, 16, 23, 16, 1930, 24, 3967, 18, 14880, 12, 22984, 13, 1982, 2580, 1922, 3]}, "items": [{"id": "p_27", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_28", "content": "NH3 [SEP] d venous blood was sampled at 0, 1, 2, 3, and 4 hours. Ammonia (NH3) was higher in patients who, during continuous therapy, complai", "tokenized_content": [2, 22984, 3, 46, 8562, 2877, 1982, 8783, 2019, 20, 16, 21, 16, 22, 16, 23, 16, 1930, 24, 3967, 18, 14880, 12, 22984, 13, 1982, 2580, 1922, 2132, 2746, 16, 3]}, "items": [{"id": "p_28", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_29", "content": "drowsiness [SEP] igher in patients who, during continuous therapy, complained of drowsiness (7 patients) than in those who were symptom-free (17 patients),", "tokenized_content": [2, 29247, 6777, 1979, 3, 20733, 1915, 1922, 2132, 2746, 16, 2409, 4798, 3181, 16, 26199, 1927, 29247, 6777, 1979, 12, 27, 2132, 13, 2254, 1922, 2690, 2746, 1985, 3226, 17, 3]}, "items": [{"id": "p_29", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_30", "content": "haloperidol [SEP] n male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induc", "tokenized_content": [2, 25107, 3, 56, 4005, 3615, 18, 26406, 4107, 4306, 1922, 43, 16020, 1927, 25107, 17, 2719, 4233, 9431, 1012, 1930, 43, 5740, 5455, 1927, 11466, 12492, 11119, 7969, 2912, 17, 3]}, "items": [{"id": "p_30", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_31", "content": "catalepsy [SEP] nin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. ", "tokenized_content": [2, 4233, 9431, 1012, 3, 12117, 4107, 4306, 1922, 43, 16020, 1927, 25107, 17, 2719, 4233, 9431, 1012, 1930, 43, 5740, 5455, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 15534, 3]}, "items": [{"id": "p_31", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_32", "content": "apomorphine [SEP] on of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significan", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 1990, 1927, 25107, 17, 2719, 4233, 9431, 1012, 1930, 43, 5740, 5455, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 15534, 18, 3950, 26406, 3]}, "items": [{"id": "p_32", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_33", "content": "hyperactivity [SEP] duced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral G", "tokenized_content": [2, 15534, 3, 10677, 1919, 4233, 9431, 1012, 1930, 43, 5740, 5455, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 15534, 18, 3950, 26406, 2719, 43, 2228, 3714, 1922, 20102, 1024, 3]}, "items": [{"id": "p_33", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_34", "content": "DA [SEP] icant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discus", "tokenized_content": [2, 3692, 3, 14784, 4905, 3714, 1922, 20102, 1024, 10279, 2455, 2308, 2239, 3185, 1922, 13165, 3692, 1930, 19428, 1030, 3110, 2014, 10279, 2455, 18, 1920, 2274, 2032, 2863, 1957, 3]}, "items": [{"id": "p_34", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_35", "content": "DOPAC [SEP] ecrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in vie", "tokenized_content": [2, 19428, 1030, 3, 25848, 18013, 1021, 1922, 20102, 1024, 10279, 2455, 2308, 2239, 3185, 1922, 13165, 3692, 1930, 19428, 1030, 3110, 2014, 10279, 2455, 18, 1920, 2274, 2032, 5601, 1922, 3]}, "items": [{"id": "p_35", "content": "3,4-Dihydroxyphenylacetic Acid [SEP] A deaminated metabolite of LEVODOPA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 3, 43, 30097, 8547, 1981, 9483, 1927, 26723, 18, 3]}]}
{"query": {"id": "q_36", "content": "isoproterenol [SEP] Development of isoproterenol-induced cardiac hypertrophy.", "tokenized_content": [2, 23743, 3, 2740, 1927, 23743, 17, 2719, 4435, 11014, 18, 3]}, "items": [{"id": "p_36", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_37", "content": "cardiac hypertrophy [SEP] Development of isoproterenol-induced cardiac hypertrophy.", "tokenized_content": [2, 4435, 11014, 3, 2740, 1927, 23743, 17, 2719, 4435, 11014, 18, 3]}, "items": [{"id": "p_37", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_38", "content": "cardiac hypertrophy [SEP] The development of cardiac hypertrophy was studied in adult female Wistar rats following daily subcuta", "tokenized_content": [2, 4435, 11014, 3, 1920, 2740, 1927, 4435, 11014, 1982, 3942, 1922, 4160, 4232, 15668, 3615, 2894, 4692, 5736, 26455, 3]}, "items": [{"id": "p_38", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_39", "content": "isoproterenol [SEP] t female Wistar rats following daily subcutaneous injections of isoproterenol (ISO) (0.3 mg/kg body weight). A time course was established fo", "tokenized_content": [2, 23743, 3, 62, 4232, 15668, 3615, 2894, 4692, 8634, 8775, 1927, 23743, 12, 4911, 13, 12, 20, 18, 23, 2786, 19, 3621, 3362, 3388, 13, 18, 43, 2367, 4914, 1982, 3]}, "items": [{"id": "p_39", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_40", "content": "ISO [SEP]  rats following daily subcutaneous injections of isoproterenol (ISO) (0.3 mg/kg body weight). A time course was established for the", "tokenized_content": [2, 4911, 3, 3615, 2894, 4692, 8634, 8775, 1927, 23743, 12, 4911, 13, 12, 20, 18, 23, 2786, 19, 3621, 3362, 3388, 13, 18, 43, 2367, 4914, 1982, 4379, 1958, 1920, 3]}, "items": [{"id": "p_40", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_41", "content": "hydroxyproline [SEP]  for the change in tissue mass, RNA and DNA content, as well as hydroxyproline content. Heart weight increased 44% after 8 days of treatment w", "tokenized_content": [2, 20990, 21856, 3, 1958, 1920, 3185, 1922, 2960, 3411, 16, 3146, 1930, 2678, 3919, 16, 1966, 2486, 1966, 20990, 21856, 3919, 18, 4003, 3388, 2502, 4044, 9, 2256, 28, 3000, 3]}, "items": [{"id": "p_41", "content": "Hydroxyproline [SEP] A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.\n  ", "score": 1, "type": null, "tokenized_content": [2, 20990, 21856, 3, 43, 9420, 1981, 2386, 1927, 1920, 2042, 3522, 2687, 12958, 18, 43, 6179, 1922, 18265, 2687, 2112, 3211, 1922, 5761, 20990, 21856, 3337, 18, 3]}]}
{"query": {"id": "q_42", "content": "hypertrophic [SEP]  DNA content was unchanged during the early stage (1-4 days) of hypertrophic growth but increased to a new steady-state level 19% above the ", "tokenized_content": [2, 17437, 3, 2678, 3919, 1982, 9913, 2409, 1920, 3120, 3587, 12, 21, 17, 24, 3000, 13, 1927, 17437, 2905, 2308, 2502, 1942, 43, 2814, 8121, 17, 3360, 2237, 2282, 9, 3]}, "items": [{"id": "p_42", "content": "Hypertrophy [SEP] General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor ", "score": 1, "type": null, "tokenized_content": [2, 11014, 3, 3335, 2760, 1922, 9390, 1927, 43, 3131, 2014, 3090, 2810, 1942, 2024, 16363, 1930, 4858, 1927, 13315, 1930, 21417, 16, 2084, 2810, 1942, 2798, 3]}]}
{"query": {"id": "q_43", "content": "hypertrophy [SEP] The development of cardiac hypertrophy was studied in adult female Wistar rats following daily subcuta", "tokenized_content": [2, 11014, 3, 1920, 2740, 1927, 4435, 11014, 1982, 3942, 1922, 4160, 4232, 15668, 3615, 2894, 4692, 5736, 26455, 3]}, "items": [{"id": "p_43", "content": "Hypertrophy [SEP] General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor ", "score": 1, "type": null, "tokenized_content": [2, 11014, 3, 3335, 2760, 1922, 9390, 1927, 43, 3131, 2014, 3090, 2810, 1942, 2024, 16363, 1930, 4858, 1927, 13315, 1930, 21417, 16, 2084, 2810, 1942, 2798, 3]}]}
{"query": {"id": "q_44", "content": "hyperplasia [SEP] epresent a complex integration of both cellular hypertrophy and hyperplasia within the heart.", "tokenized_content": [2, 13095, 3, 16331, 2124, 4905, 43, 2796, 7122, 1927, 2321, 3689, 11014, 1930, 13095, 2651, 1920, 4003, 18, 3]}, "items": [{"id": "p_44", "content": "Hyperplasia [SEP] An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increa", "score": 1, "type": null, "tokenized_content": [2, 13095, 3, 1925, 2760, 1922, 1920, 2529, 1927, 2094, 1922, 43, 2960, 2014, 3090, 2979, 2798, 3337, 18, 2176, 11457, 2037, 11014, 16, 2154, 1977, 1925, 2203, 1019, 3]}]}
{"query": {"id": "q_45", "content": "carcinogenic [SEP] Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male", "tokenized_content": [2, 20711, 3, 2081, 17, 20711, 2495, 1927, 7599, 2199, 7959, 1990, 9238, 29917, 1023, 12559, 1927, 4005, 3]}, "items": [{"id": "p_45", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_46", "content": "retinyl acetate [SEP] Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with bu", "tokenized_content": [2, 7599, 2199, 7959, 3, 2081, 17, 20711, 2495, 1927, 7599, 2199, 7959, 1990, 9238, 29917, 1023, 12559, 1927, 4005, 14499, 6609, 3615, 2719, 1956, 3168, 3]}, "items": [{"id": "p_46", "content": "retinol acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23256, 7959, 3, 3]}]}
{"query": {"id": "q_47", "content": "forestomach carcinogenesis [SEP] Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.", "tokenized_content": [2, 9238, 29917, 1023, 12559, 3, 2081, 17, 20711, 2495, 1927, 7599, 2199, 7959, 1990, 9238, 29917, 1023, 12559, 1927, 4005, 14499, 6609, 3615, 2719, 1956, 16936, 1981, 8275, 8150, 2204, 3]}, "items": [{"id": "p_47", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_48", "content": "butylated hydroxyanisole [SEP] te on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.", "tokenized_content": [2, 16936, 1981, 8275, 8150, 2204, 1952, 3, 3602, 1990, 9238, 29917, 1023, 12559, 1927, 4005, 14499, 6609, 3615, 2719, 1956, 16936, 1981, 8275, 8150, 2204, 1952, 18, 3]}, "items": [{"id": "p_48", "content": "Butylated Hydroxyanisole [SEP] Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16936, 1981, 8275, 8150, 2204, 1952, 3, 5515, 1927, 22, 17, 1930, 23, 17, 15757, 17, 16936, 17, 24, 17, 17954, 27451, 1036, 1988, 1977, 2251, 1966, 1925, 7335, 1922, 9660, 16, 21164, 1036, 16, 1930, 15985, 18, 3]}]}
{"query": {"id": "q_49", "content": "retinyl acetate [SEP] The potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach ", "tokenized_content": [2, 7599, 2199, 7959, 3, 1920, 2889, 12691, 2495, 1927, 7599, 2199, 7959, 12, 4313, 13, 1990, 16936, 1981, 8275, 8150, 2204, 1952, 12, 9710, 1019, 13, 17, 2719, 3067, 9238, 3]}, "items": [{"id": "p_49", "content": "retinol acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23256, 7959, 3, 3]}]}
{"query": {"id": "q_50", "content": "RA [SEP] The potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumo", "tokenized_content": [2, 4313, 3, 1920, 2889, 12691, 2495, 1927, 7599, 2199, 7959, 12, 4313, 13, 1990, 16936, 1981, 8275, 8150, 2204, 1952, 12, 9710, 1019, 13, 17, 2719, 3067, 9238, 29917, 1023, 3]}, "items": [{"id": "p_50", "content": "retinol acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23256, 7959, 3, 3]}]}
{"query": {"id": "q_51", "content": "butylated hydroxyanisole [SEP] The potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male ", "tokenized_content": [2, 16936, 1981, 8275, 8150, 2204, 1952, 3, 1920, 2889, 12691, 2495, 1927, 7599, 2199, 7959, 12, 4313, 13, 1990, 16936, 1981, 8275, 8150, 2204, 1952, 12, 9710, 1019, 13, 17, 3]}, "items": [{"id": "p_51", "content": "Butylated Hydroxyanisole [SEP] Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16936, 1981, 8275, 8150, 2204, 1952, 3, 5515, 1927, 22, 17, 1930, 23, 17, 15757, 17, 16936, 17, 24, 17, 17954, 27451, 1036, 1988, 1977, 2251, 1966, 1925, 7335, 1922, 9660, 16, 21164, 1036, 16, 1930, 15985, 18, 3]}]}
{"query": {"id": "q_52", "content": "BHA [SEP] ing effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 ", "tokenized_content": [2, 9710, 1019, 3, 30393, 2495, 1927, 7599, 2199, 7959, 12, 4313, 13, 1990, 16936, 1981, 8275, 8150, 2204, 1952, 12, 9710, 1019, 13, 17, 2719, 3067, 9238, 29917, 1023, 11472, 3]}, "items": [{"id": "p_52", "content": "Butylated Hydroxyanisole [SEP] Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16936, 1981, 8275, 8150, 2204, 1952, 3, 5515, 1927, 22, 17, 1930, 23, 17, 15757, 17, 16936, 17, 24, 17, 17954, 27451, 1036, 1988, 1977, 2251, 1966, 1925, 7335, 1922, 9660, 16, 21164, 1036, 16, 1930, 15985, 18, 3]}]}
{"query": {"id": "q_53", "content": "forestomach tumorigenesis [SEP] inyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 rats, 5 weeks of age, were maintained o", "tokenized_content": [2, 9238, 29917, 1023, 11472, 3, 1922, 2199, 7959, 12, 4313, 13, 1990, 16936, 1981, 8275, 8150, 2204, 1952, 12, 9710, 1019, 13, 17, 2719, 3067, 9238, 29917, 1023, 11472, 1982, 3]}, "items": [{"id": "p_53", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_54", "content": "forestomach tumors [SEP]  RA significantly (P less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats wi", "tokenized_content": [2, 9238, 29917, 1023, 3861, 3, 4313, 2567, 12, 58, 2941, 2254, 20, 18, 2914, 13, 2502, 1920, 4332, 1927, 9238, 29917, 1023, 3861, 12, 10364, 2024, 14668, 2954, 1930, 5373, 3]}, "items": [{"id": "p_54", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_55", "content": "squamous cell papilloma [SEP]  less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3", "tokenized_content": [2, 10364, 2024, 14668, 2954, 3, 2941, 2254, 20, 18, 2914, 13, 2502, 1920, 4332, 1927, 9238, 29917, 1023, 3861, 12, 10364, 2024, 14668, 2954, 1930, 5373, 13, 1942, 3276, 9, 3]}, "items": [{"id": "p_55", "content": "Papilloma [SEP] A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm co", "score": 1, "type": null, "tokenized_content": [2, 14668, 2954, 3, 43, 28868, 6514, 8867, 4944, 2798, 22699, 2037, 1920, 7510, 3154, 31, 2253, 12565, 16, 43, 8867, 4944, 12132, 2081, 3]}]}
{"query": {"id": "q_56", "content": "carcinoma [SEP] he incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3/20, one rat w", "tokenized_content": [2, 5373, 3, 2234, 4332, 1927, 9238, 29917, 1023, 3861, 12, 10364, 2024, 14668, 2954, 1930, 5373, 13, 1942, 3276, 9, 12, 29, 19, 2461, 16, 22, 3615, 1956, 5373, 13, 3]}, "items": [{"id": "p_56", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_57", "content": "epithelial hyperplasia [SEP] ependent enhancing effect on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25", "tokenized_content": [2, 4944, 13095, 3, 2630, 2663, 9221, 2495, 1990, 1920, 2740, 1927, 1920, 9710, 1019, 17, 2719, 4944, 13095, 18, 3861, 16, 2136, 14668, 4956, 16, 1985, 2719, 1922, 23, 3615, 3]}, "items": [{"id": "p_57", "content": "Focal Epithelial Hyperplasia [SEP] Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, pr", "score": 1, "type": null, "tokenized_content": [2, 8083, 4944, 13095, 3, 13095, 1927, 1920, 27103, 3260, 1927, 1920, 30516, 16, 14761, 16, 1930, 2941, 5384, 16, 1920, 19630, 9680, 16, 13363, 1927, 1920, 11701, 16, 1930, 19471, 16, 2033, 3]}]}
{"query": {"id": "q_58", "content": "Tumors [SEP] t on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and", "tokenized_content": [2, 3861, 3, 62, 1990, 1920, 2740, 1927, 1920, 9710, 1019, 17, 2719, 4944, 13095, 18, 3861, 16, 2136, 14668, 4956, 16, 1985, 2719, 1922, 23, 3615, 12, 2752, 9, 13, 3]}, "items": [{"id": "p_58", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_59", "content": "papillomas [SEP] elopment of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and in one rat (10%", "tokenized_content": [2, 14668, 4956, 3, 2349, 2011, 2017, 1927, 1920, 9710, 1019, 17, 2719, 4944, 13095, 18, 3861, 16, 2136, 14668, 4956, 16, 1985, 2719, 1922, 23, 3615, 12, 2752, 9, 13, 3]}, "items": [{"id": "p_59", "content": "Papilloma [SEP] A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm co", "score": 1, "type": null, "tokenized_content": [2, 14668, 2954, 3, 43, 28868, 6514, 8867, 4944, 2798, 22699, 2037, 1920, 7510, 3154, 31, 2253, 12565, 16, 43, 8867, 4944, 12132, 2081, 3]}]}
{"query": {"id": "q_60", "content": "forestomach carcinogenesis [SEP] e findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat.", "tokenized_content": [2, 9238, 29917, 1023, 12559, 3, 47, 3056, 3579, 1988, 4313, 19300, 1966, 43, 2081, 17, 26343, 1922, 1920, 9710, 1019, 9238, 29917, 1023, 12559, 1927, 1920, 3067, 18, 3]}, "items": [{"id": "p_60", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_61", "content": "Ketanserin [SEP] Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.", "tokenized_content": [2, 7892, 2075, 16654, 3, 7892, 2075, 16654, 9111, 28817, 17913, 25722, 17, 2719, 3760, 20471, 18, 3]}, "items": [{"id": "p_61", "content": "Ketanserin [SEP] A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering b", "score": 1, "type": null, "tokenized_content": [2, 7892, 2075, 16654, 3, 43, 5328, 11153, 3148, 8151, 1956, 5015, 13672, 3148, 7472, 3879, 18, 1920, 2838, 1977, 3655, 1922, 11187, 44, 3]}]}
{"query": {"id": "q_62", "content": "alfentanil [SEP] Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.", "tokenized_content": [2, 17913, 25722, 3, 7892, 2075, 16654, 9111, 28817, 17913, 25722, 17, 2719, 3760, 20471, 18, 3]}, "items": [{"id": "p_62", "content": "Alfentanil [SEP] A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recov", "score": 1, "type": null, "tokenized_content": [2, 17913, 25722, 3, 43, 3662, 17, 8290, 9384, 16111, 1930, 14501, 10533, 1927, 20311, 18, 2176, 9300, 1925, 3120, 3833, 14501, 2495, 1930, 5867, 29326, 1020, 3]}]}
{"query": {"id": "q_63", "content": "muscle rigidity [SEP] Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.", "tokenized_content": [2, 3760, 20471, 3, 7892, 2075, 16654, 9111, 28817, 17913, 25722, 17, 2719, 3760, 20471, 18, 3]}, "items": [{"id": "p_63", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_64", "content": "ketanserin [SEP] Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, si", "tokenized_content": [2, 7892, 2075, 16654, 3, 5510, 9111, 1956, 7892, 2075, 16654, 16, 43, 4322, 2487, 2601, 17, 22, 11153, 3148, 8151, 16, 5998, 3]}, "items": [{"id": "p_64", "content": "Ketanserin [SEP] A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering b", "score": 1, "type": null, "tokenized_content": [2, 7892, 2075, 16654, 3, 43, 5328, 11153, 3148, 8151, 1956, 5015, 13672, 3148, 7472, 3879, 18, 1920, 2838, 1977, 3655, 1922, 11187, 44, 3]}]}
{"query": {"id": "q_65", "content": "serotonin [SEP] emic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidi", "tokenized_content": [2, 11153, 3, 2391, 1935, 9111, 1956, 7892, 2075, 16654, 16, 43, 4322, 2487, 2601, 17, 22, 11153, 3148, 8151, 16, 2567, 8060, 1920, 3760, 12383, 1033, 3]}, "items": [{"id": "p_65", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_66", "content": "muscle rigidity [SEP] e-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfe", "tokenized_content": [2, 3760, 20471, 3, 47, 17, 22, 11153, 3148, 8151, 16, 2567, 8060, 1920, 3760, 20471, 4152, 1922, 3615, 2007, 1920, 6828, 3662, 17, 8290, 27059, 7829, 17913, 1021, 3]}, "items": [{"id": "p_66", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_67", "content": "alfentanil [SEP] dity produced in rats by the potent short-acting opiate agonist alfentanil. Following placement of subcutaneous electrodes in each animal'", "tokenized_content": [2, 17913, 25722, 3, 2137, 3145, 4152, 1922, 3615, 2007, 1920, 6828, 3662, 17, 8290, 27059, 7829, 17913, 25722, 18, 2894, 9555, 1927, 8634, 9115, 1922, 2362, 4027, 11, 3]}, "items": [{"id": "p_67", "content": "Alfentanil [SEP] A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recov", "score": 1, "type": null, "tokenized_content": [2, 17913, 25722, 3, 43, 3662, 17, 8290, 9384, 16111, 1930, 14501, 10533, 1927, 20311, 18, 2176, 9300, 1925, 3120, 3833, 14501, 2495, 1930, 5867, 29326, 1020, 3]}]}
{"query": {"id": "q_68", "content": "rigidity [SEP] otonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfe", "tokenized_content": [2, 20471, 3, 7608, 6655, 3148, 8151, 16, 2567, 8060, 1920, 3760, 20471, 4152, 1922, 3615, 2007, 1920, 6828, 3662, 17, 8290, 27059, 7829, 17913, 1021, 3]}, "items": [{"id": "p_68", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_69", "content": "Chlordiazepoxide [SEP] ographic activity compared with animals pretreated with saline. Chlordiazepoxide at doses up to 10 mg/kg failed to significantly influence the r", "tokenized_content": [2, 4891, 7408, 18570, 6211, 3, 17395, 5524, 24888, 1030, 2455, 2452, 1956, 3555, 12152, 1956, 5977, 18, 4891, 7408, 18570, 6211, 2019, 5312, 2353, 1942, 2119, 2786, 19, 3621, 6617, 3]}, "items": [{"id": "p_69", "content": "Chlordiazepoxide [SEP] An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symp", "score": 1, "type": null, "tokenized_content": [2, 4891, 7408, 18570, 6211, 3, 1925, 28932, 27266, 10533, 1956, 26572, 2031, 16, 28514, 16, 1930, 14701, 18522, 1030, 3879, 18, 2176, 2258, 2222, 2252, 2251, 1922, 1920, 29148, 3]}]}
{"query": {"id": "q_70", "content": "respiratory depression [SEP] s the interaction of possibly enhanced CNS, cardiovascular, and respiratory depression.", "tokenized_content": [2, 5481, 4621, 3, 61, 1920, 2835, 1927, 6553, 4256, 7520, 16, 5321, 16, 1930, 5481, 4621, 18, 3]}, "items": [{"id": "p_70", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_71", "content": "Glycopyrronium [SEP] Glycopyrronium requirements for antagonism of the muscarinic side effects of e", "tokenized_content": [2, 8821, 3553, 11018, 1989, 3, 8821, 3553, 11018, 1989, 8456, 1958, 18394, 1927, 1920, 20318, 4159, 2564, 1927, 47, 3]}, "items": [{"id": "p_71", "content": "Glycopyrrolate [SEP] A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with", "score": 1, "type": null, "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 43, 20318, 8151, 2251, 1966, 1925, 8059, 4302, 18538, 12486, 16, 1922, 2673, 4414, 1927, 1920, 8375, 6482, 16, 1930, 1942, 4412, 12999, 1929, 1956, 3]}]}
{"query": {"id": "q_72", "content": "edrophonium [SEP] m requirements for antagonism of the muscarinic side effects of edrophonium.", "tokenized_content": [2, 3347, 2789, 15414, 3, 55, 8456, 1958, 18394, 1927, 1920, 20318, 4159, 2564, 1927, 3347, 2789, 15414, 18, 3]}, "items": [{"id": "p_72", "content": "Edrophonium [SEP] A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It h", "score": 1, "type": null, "tokenized_content": [2, 3347, 2789, 15414, 3, 43, 4052, 17, 4727, 16, 3662, 17, 8290, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 4435, 16934, 1930, 1922, 1920, 3574, 1927, 3057, 27618, 8572, 12413, 1937, 18, 2176, 50, 3]}]}
{"query": {"id": "q_73", "content": "glycopyrronium [SEP] e compared, in 60 adult patients, the cardiovascular effects of glycopyrronium 5 micrograms kg-1 and 10 micrograms kg-1 given either simultane", "tokenized_content": [2, 8821, 3553, 11018, 1989, 3, 47, 2452, 16, 1922, 3276, 4160, 2132, 16, 1920, 5321, 2564, 1927, 8821, 3553, 11018, 1989, 25, 13362, 3621, 17, 21, 1930, 2119, 13362, 3621, 3]}, "items": [{"id": "p_73", "content": "Glycopyrrolate [SEP] A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with", "score": 1, "type": null, "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 43, 20318, 8151, 2251, 1966, 1925, 8059, 4302, 18538, 12486, 16, 1922, 2673, 4414, 1927, 1920, 8375, 6482, 16, 1930, 1942, 4412, 12999, 1929, 1956, 3]}]}
{"query": {"id": "q_74", "content": "edrophonium [SEP]  10 micrograms kg-1 given either simultaneously or 1 min before edrophonium 1 mg kg-1. Significant differences between the four groups were", "tokenized_content": [2, 3347, 2789, 15414, 3, 2119, 13362, 3621, 17, 21, 3258, 3108, 7159, 2014, 21, 2360, 3119, 3347, 2789, 15414, 21, 2786, 3621, 17, 21, 18, 2228, 2886, 2192, 1920, 3006, 3]}, "items": [{"id": "p_74", "content": "Edrophonium [SEP] A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It h", "score": 1, "type": null, "tokenized_content": [2, 3347, 2789, 15414, 3, 43, 4052, 17, 4727, 16, 3662, 17, 8290, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 4435, 16934, 1930, 1922, 1920, 3574, 1927, 3057, 27618, 8572, 12413, 1937, 18, 2176, 50, 3]}]}
{"query": {"id": "q_75", "content": "bradycardias [SEP] ophonium, was sufficient to minimize early, edrophonium-induced bradycardias. This low dose of glycopyrronium provided good control of oroph", "tokenized_content": [2, 26192, 1036, 3, 11409, 15414, 16, 1982, 5409, 1942, 9491, 3120, 16, 3347, 2789, 15414, 17, 2719, 26192, 1036, 18, 2052, 2330, 3253, 1927, 8821, 3553, 11018, 1989, 3675, 4227, 3]}, "items": [{"id": "p_75", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_76", "content": "fentanyl [SEP] ement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat.", "tokenized_content": [2, 20311, 3, 2391, 1939, 1927, 6730, 4815, 3176, 1952, 1957, 1930, 27358, 20221, 1922, 20311, 17, 2719, 12330, 20471, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_76", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_77", "content": "muscular rigidity [SEP] eruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat.", "tokenized_content": [2, 12330, 20471, 3, 25110, 1952, 1957, 1930, 27358, 20221, 1922, 20311, 17, 2719, 12330, 20471, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_77", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_78", "content": "muscular rigidity [SEP] Whereas muscular rigidity is a well-known side effect that is associated with high-dose f", "tokenized_content": [2, 12330, 20471, 3, 3417, 12330, 20471, 1977, 43, 2486, 17, 3171, 4159, 2495, 1988, 1977, 2458, 1956, 2149, 17, 3253, 48, 3]}, "items": [{"id": "p_78", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_79", "content": "fentanyl [SEP] y is a well-known side effect that is associated with high-dose fentanyl anesthesia, a paucity of information exists with regard to its ", "tokenized_content": [2, 20311, 3, 67, 1977, 43, 2486, 17, 3171, 4159, 2495, 1988, 1977, 2458, 1956, 2149, 17, 3253, 20311, 8871, 16, 43, 19937, 1927, 2988, 8655, 1956, 4623, 1942, 2496, 3]}, "items": [{"id": "p_79", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_80", "content": "ketamine [SEP] is phenomenon, using male Sprague-Dawley rats anesthetized with ketamine. Under proper control of respiration, body temperature and end-", "tokenized_content": [2, 14049, 3, 1977, 7902, 16, 2193, 4005, 15684, 17, 15798, 3615, 12137, 1956, 14049, 18, 2441, 3405, 2285, 1927, 11695, 16, 3362, 3449, 1930, 2482, 17, 3]}, "items": [{"id": "p_80", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_81", "content": "CO2 [SEP] r proper control of respiration, body temperature and end-tidal CO2, intravenous administration of fentanyl (50 or 100 micrograms/k", "tokenized_content": [2, 6333, 3, 60, 3405, 2285, 1927, 11695, 16, 3362, 3449, 1930, 2482, 17, 18776, 6333, 16, 7307, 4183, 1927, 20311, 12, 2761, 2014, 2813, 13362, 19, 53, 3]}, "items": [{"id": "p_81", "content": "Carbon Dioxide [SEP] A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5056, 15422, 3, 43, 29500, 16, 12685, 5427, 4422, 1988, 2112, 1998, 5333, 2007, 1920, 3362, 1930, 1977, 4680, 1958, 1920, 11695, 4048, 1927, 4793, 1930, 3555, 18, 3]}]}
{"query": {"id": "q_82", "content": "prazosin [SEP]  coeruleus or pretreatment with the alpha-adrenoceptor blocker, prazosin. Microinjection of fentanyl (2.5 micrograms/50 nl) directly int", "tokenized_content": [2, 29041, 5872, 3, 4815, 3176, 1952, 1957, 2014, 9111, 1956, 1920, 4595, 17, 25090, 14580, 16, 29041, 5872, 18, 24283, 1927, 20311, 12, 22, 18, 25, 13362, 19, 2761, 9092, 3]}, "items": [{"id": "p_82", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_83", "content": "Cerebral sinus thrombosis [SEP] Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrha", "tokenized_content": [2, 6329, 9414, 11354, 3, 6329, 9414, 11354, 1966, 43, 2889, 7320, 1927, 12244, 3693, 21092, 4274, 2311, 1922, 3925, 6990, 1019, 3]}, "items": [{"id": "p_83", "content": "Sinus Thrombosis, Intracranial [SEP] Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within", "score": 1, "type": null, "tokenized_content": [2, 9414, 11354, 16, 12179, 3, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 13598, 28436, 16, 3103, 11403, 17, 26285, 8562, 5628, 18287, 2651, 3]}]}
{"query": {"id": "q_84", "content": "menorrhagia [SEP] rombosis as a potential hazard of antifibrinolytic treatment in menorrhagia.", "tokenized_content": [2, 3925, 6990, 17378, 3, 15612, 29258, 1937, 1966, 43, 2889, 7320, 1927, 12244, 3693, 21092, 4274, 2311, 1922, 3925, 6990, 17378, 18, 3]}, "items": [{"id": "p_84", "content": "Menorrhagia [SEP] Excessive uterine bleeding during MENSTRUATION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3925, 6990, 17378, 3, 9122, 10885, 7633, 2409, 14333, 10874, 18, 3]}]}
{"query": {"id": "q_85", "content": "left transverse sinus thrombosis [SEP] escribe a 42-year-old woman who developed superior sagittal and left transverse sinus thrombosis associated with prolonged epsilon-aminocaproic acid therapy for", "tokenized_content": [2, 3506, 11740, 9414, 11354, 3, 14382, 3027, 5873, 43, 3858, 17, 2476, 17, 4156, 10440, 2746, 3530, 6566, 13486, 1930, 3506, 11740, 9414, 11354, 2458, 1956, 7171, 22206, 17, 3835, 3]}, "items": [{"id": "p_85", "content": "Lateral Sinus Thrombosis [SEP] Formation or presence of a blood clot (THROMBUS) in the LATERAL SINUSES. This condition is often associated with ear infections ", "score": 1, "type": null, "tokenized_content": [2, 5347, 9414, 11354, 3, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 5347, 28436, 18, 2052, 2625, 1977, 3868, 2458, 1956, 4352, 5024, 3]}]}
{"query": {"id": "q_86", "content": "epsilon-aminocaproic acid [SEP]  and left transverse sinus thrombosis associated with prolonged epsilon-aminocaproic acid therapy for menorrhagia. This antifibrinolytic agent has been u", "tokenized_content": [2, 22206, 17, 3835, 9991, 1931, 1935, 2687, 3, 1930, 3506, 11740, 9414, 11354, 2458, 1956, 7171, 22206, 17, 3835, 9991, 1931, 1935, 2687, 3181, 1958, 3925, 6990, 17378, 18, 2052, 3]}, "items": [{"id": "p_86", "content": "Aminocaproic Acid [SEP] An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3835, 9991, 1931, 1935, 2687, 3, 1925, 12244, 3693, 21092, 4274, 5899, 1988, 8016, 2007, 7918, 17485, 15497, 2154, 2162, 9450, 6586, 3879, 18, 3]}]}
{"query": {"id": "q_87", "content": "menorrhagia [SEP] associated with prolonged epsilon-aminocaproic acid therapy for menorrhagia. This antifibrinolytic agent has been used in women with menorr", "tokenized_content": [2, 3925, 6990, 17378, 3, 2458, 1956, 7171, 22206, 17, 3835, 9991, 1931, 1935, 2687, 3181, 1958, 3925, 6990, 17378, 18, 2052, 12244, 3693, 21092, 4274, 5899, 2258, 2252, 2251, 1922, 3]}, "items": [{"id": "p_87", "content": "Menorrhagia [SEP] Excessive uterine bleeding during MENSTRUATION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3925, 6990, 17378, 3, 9122, 10885, 7633, 2409, 14333, 10874, 18, 3]}]}
{"query": {"id": "q_88", "content": "blood loss [SEP] n used in women with menorrhagia to promote clotting and reduce blood loss. Although increased risk of thromboembolic disease has been rep", "tokenized_content": [2, 2877, 3257, 3, 56, 2251, 1922, 3089, 1956, 3925, 6990, 17378, 1942, 5527, 23625, 1930, 4412, 2877, 3257, 18, 2876, 2502, 2565, 1927, 25580, 2573, 2258, 2252, 3073, 3]}, "items": [{"id": "p_88", "content": "Postpartum Hemorrhage [SEP] Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than ", "score": 1, "type": null, "tokenized_content": [2, 13171, 10489, 3, 5799, 2877, 3257, 2037, 10885, 7633, 2458, 1956, 18902, 3876, 2014, 24445, 18, 2176, 1977, 3608, 1966, 2877, 3257, 3430, 2254, 3]}]}
{"query": {"id": "q_89", "content": "thromboembolic disease [SEP] mote clotting and reduce blood loss. Although increased risk of thromboembolic disease has been reported during treatment with epsilon-aminocaproic ac", "tokenized_content": [2, 25580, 2573, 3, 12798, 1021, 23625, 1930, 4412, 2877, 3257, 18, 2876, 2502, 2565, 1927, 25580, 2573, 2258, 2252, 2568, 2409, 2311, 1956, 22206, 17, 3835, 9991, 1931, 1935, 2000, 3]}, "items": [{"id": "p_89", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_90", "content": "cerebral sinus thrombosis [SEP]  been reported during treatment with epsilon-aminocaproic acid, cerebral sinus thrombosis has not been previously described. Careful use of epsilon-amino", "tokenized_content": [2, 6329, 9414, 11354, 3, 2252, 2568, 2409, 2311, 1956, 22206, 17, 3835, 9991, 1931, 1935, 2687, 16, 6329, 9414, 11354, 2258, 2084, 2252, 3024, 2910, 18, 8279, 2485, 1927, 22206, 3]}, "items": [{"id": "p_90", "content": "Sinus Thrombosis, Intracranial [SEP] Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within", "score": 1, "type": null, "tokenized_content": [2, 9414, 11354, 16, 12179, 3, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 13598, 28436, 16, 3103, 11403, 17, 26285, 8562, 5628, 18287, 2651, 3]}]}
{"query": {"id": "q_91", "content": "Hemorrhagic [SEP] Hemorrhagic cystitis complicating bone marrow transplantation.", "tokenized_content": [2, 16052, 3, 16052, 9446, 3678, 6581, 6102, 2104, 3622, 6599, 6530, 18, 3]}, "items": [{"id": "p_91", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_92", "content": "cystitis [SEP] Hemorrhagic cystitis complicating bone marrow transplantation.", "tokenized_content": [2, 9446, 3678, 3, 16052, 9446, 3678, 6581, 6102, 2104, 3622, 6599, 6530, 18, 3]}, "items": [{"id": "p_92", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_93", "content": "Hemorrhagic [SEP] Hemorrhagic cystitis is a potentially serious complication of high-dose cyc", "tokenized_content": [2, 16052, 3, 16052, 9446, 3678, 1977, 43, 5063, 7433, 9388, 1927, 2149, 17, 3253, 21309, 3]}, "items": [{"id": "p_93", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_94", "content": "cystitis [SEP] Hemorrhagic cystitis is a potentially serious complication of high-dose cyclophospha", "tokenized_content": [2, 9446, 3678, 3, 16052, 9446, 3678, 1977, 43, 5063, 7433, 9388, 1927, 2149, 17, 3253, 20585, 10647, 3508, 2722, 3]}, "items": [{"id": "p_94", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_95", "content": "cyclophosphamide [SEP] gic cystitis is a potentially serious complication of high-dose cyclophosphamide therapy administered before bone marrow transplantation. As sta", "tokenized_content": [2, 17135, 3, 7217, 1030, 9446, 3678, 1977, 43, 5063, 7433, 9388, 1927, 2149, 17, 3253, 17135, 3181, 5254, 3119, 3622, 6599, 6530, 18, 1966, 23891, 3]}, "items": [{"id": "p_95", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_96", "content": "mesna [SEP] gation, we conducted a feasibility trial of uroprophylaxis with mesna, which neutralizes the hepatic metabolite of cyclophosphamide t", "tokenized_content": [2, 4438, 2175, 3, 13530, 2001, 16, 2038, 3609, 43, 10067, 3046, 1927, 14984, 20194, 30338, 5148, 18068, 1036, 1956, 4438, 2175, 16, 2154, 25885, 1036, 1920, 6095, 9483, 1927, 17135, 3]}, "items": [{"id": "p_96", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_97", "content": "hemorrhagic [SEP] tralizes the hepatic metabolite of cyclophosphamide that causes hemorrhagic cystitis. Of 97 patients who received standard prophylaxis, 4 h", "tokenized_content": [2, 16052, 3, 3390, 12191, 20887, 1920, 6095, 9483, 1927, 17135, 1988, 5092, 16052, 9446, 3678, 18, 1927, 5749, 2132, 2746, 4004, 2970, 12725, 16, 24, 50, 3]}, "items": [{"id": "p_97", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_98", "content": "benzodiazepine [SEP] Reversal of central benzodiazepine effects by flumazenil after intravenous conscious sedation with", "tokenized_content": [2, 27266, 3, 12393, 1927, 4101, 27266, 2564, 2007, 2848, 3368, 7490, 1970, 2256, 7307, 11993, 15263, 1956, 3]}, "items": [{"id": "p_98", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_99", "content": "flumazenil [SEP] Reversal of central benzodiazepine effects by flumazenil after intravenous conscious sedation with diazepam and opioids:", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 12393, 1927, 4101, 27266, 2564, 2007, 2848, 3368, 7490, 1970, 2256, 7307, 11993, 15263, 1956, 26079, 1930, 16218, 30, 3]}, "items": [{"id": "p_99", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_100", "content": "diazepam [SEP] effects by flumazenil after intravenous conscious sedation with diazepam and opioids: report of a double-blind multicenter study. The Fl", "tokenized_content": [2, 26079, 3, 2564, 2007, 2848, 3368, 7490, 1970, 2256, 7307, 11993, 15263, 1956, 26079, 1930, 16218, 30, 3809, 1927, 43, 4825, 17, 7109, 14620, 2161, 18, 1920, 2300, 3]}, "items": [{"id": "p_100", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_101", "content": "Flumazenil [SEP] am and opioids: report of a double-blind multicenter study. The Flumazenil in Intravenous Conscious Sedation with Diazepam Multicenter Stu", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 2150, 1930, 16218, 30, 3809, 1927, 43, 4825, 17, 7109, 14620, 2161, 18, 1920, 2848, 3368, 7490, 1970, 1922, 7307, 11993, 15263, 1956, 26079, 14620, 3]}, "items": [{"id": "p_101", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_102", "content": "Diazepam [SEP] er study. The Flumazenil in Intravenous Conscious Sedation with Diazepam Multicenter Study Group II.", "tokenized_content": [2, 26079, 3, 2668, 2161, 18, 1920, 2848, 3368, 7490, 1970, 1922, 7307, 11993, 15263, 1956, 26079, 14620, 2161, 2210, 2890, 18, 3]}, "items": [{"id": "p_102", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_103", "content": "benzodiazepine [SEP] The efficacy and safety of a new benzodiazepine antagonist, flumazenil, were assessed in a double-blind multice", "tokenized_content": [2, 27266, 3, 1920, 4348, 1930, 5407, 1927, 43, 2814, 27266, 8151, 16, 2848, 3368, 7490, 1970, 16, 1985, 3683, 1922, 43, 4825, 17, 7109, 8844, 1021, 3]}, "items": [{"id": "p_103", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_104", "content": "flumazenil [SEP] The efficacy and safety of a new benzodiazepine antagonist, flumazenil, were assessed in a double-blind multicenter study. Flumazenil ", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 1920, 4348, 1930, 5407, 1927, 43, 2814, 27266, 8151, 16, 2848, 3368, 7490, 1970, 16, 1985, 3683, 1922, 43, 4825, 17, 7109, 14620, 2161, 18, 3]}, "items": [{"id": "p_104", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_105", "content": "Flumazenil [SEP]  flumazenil, were assessed in a double-blind multicenter study. Flumazenil (mean dose, 0.76 mg) or placebo (mean dose, 8.9 ml) was adminis", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 2848, 3368, 7490, 1970, 16, 1985, 3683, 1922, 43, 4825, 17, 7109, 14620, 2161, 18, 2848, 3368, 7490, 1970, 12, 2667, 3253, 16, 20, 18, 3]}, "items": [{"id": "p_105", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_106", "content": "diazepam [SEP] nously to 130 and 67 patients, respectively, who had been given diazepam in conjunction with an opioid (fentanyl, meperidine, or morphin", "tokenized_content": [2, 26079, 3, 2239, 1957, 1954, 1942, 8761, 1930, 4838, 2132, 16, 2763, 16, 2746, 2430, 2252, 3258, 26079, 1922, 11799, 1956, 1925, 9384, 12, 20311, 16, 17257, 18842, 27099, 16, 3]}, "items": [{"id": "p_106", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_107", "content": "fentanyl [SEP] ely, who had been given diazepam in conjunction with an opioid (fentanyl, meperidine, or morphine) for the induction and maintenance of ", "tokenized_content": [2, 20311, 3, 2349, 1012, 16, 2746, 2430, 2252, 3258, 26079, 1922, 11799, 1956, 1925, 9384, 12, 20311, 16, 17257, 18842, 27099, 16, 2014, 11553, 13, 1958, 1920, 4408, 1930, 6291, 3]}, "items": [{"id": "p_107", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_108", "content": "meperidine [SEP] ad been given diazepam in conjunction with an opioid (fentanyl, meperidine, or morphine) for the induction and maintenance of intravenous ", "tokenized_content": [2, 17257, 18842, 27099, 3, 2041, 2252, 3258, 26079, 1922, 11799, 1956, 1925, 9384, 12, 20311, 16, 17257, 18842, 27099, 16, 2014, 11553, 13, 1958, 1920, 4408, 1930, 6291, 1927, 7307, 3]}, "items": [{"id": "p_108", "content": "Meperidine [SEP] A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and ", "score": 1, "type": null, "tokenized_content": [2, 17257, 18842, 27099, 3, 43, 22872, 3153, 14501, 1988, 2112, 1998, 2251, 1958, 1920, 13104, 1927, 2501, 3584, 1927, 5086, 1942, 4010, 3594, 16, 2710, 5924, 3594, 1930, 3]}]}
{"query": {"id": "q_109", "content": "morphine [SEP] iazepam in conjunction with an opioid (fentanyl, meperidine, or morphine) for the induction and maintenance of intravenous conscious sed", "tokenized_content": [2, 11553, 3, 11640, 6931, 4302, 1035, 1922, 11799, 1956, 1925, 9384, 12, 20311, 16, 17257, 18842, 27099, 16, 2014, 11553, 13, 1958, 1920, 4408, 1930, 6291, 1927, 7307, 11993, 6276, 3]}, "items": [{"id": "p_109", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_110", "content": "nausea [SEP] lated adverse experiences. The most common adverse effects were nausea and vomiting in the flumazenil group and nausea and injection-s", "tokenized_content": [2, 13759, 3, 5058, 1007, 5246, 7651, 18, 1920, 2501, 3059, 5246, 2564, 1985, 13759, 1930, 13954, 1922, 1920, 2848, 3368, 7490, 1970, 2210, 1930, 13759, 1930, 4107, 17, 61, 3]}, "items": [{"id": "p_110", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_111", "content": "vomiting [SEP] se experiences. The most common adverse effects were nausea and vomiting in the flumazenil group and nausea and injection-site pain in t", "tokenized_content": [2, 13954, 3, 2058, 7651, 18, 1920, 2501, 3059, 5246, 2564, 1985, 13759, 1930, 13954, 1922, 1920, 2848, 3368, 7490, 1970, 2210, 1930, 13759, 1930, 4107, 17, 3200, 3594, 1922, 62, 3]}, "items": [{"id": "p_111", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_112", "content": "pain [SEP]  vomiting in the flumazenil group and nausea and injection-site pain in the placebo group. Flumazenil was found to promptly reverse ", "tokenized_content": [2, 3594, 3, 13954, 1922, 1920, 2848, 3368, 7490, 1970, 2210, 1930, 13759, 1930, 4107, 17, 3200, 3594, 1922, 1920, 5936, 2210, 18, 2848, 3368, 7490, 1970, 1982, 2435, 1942, 29594, 3]}, "items": [{"id": "p_112", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_113", "content": "adenomas [SEP] Hepatic adenomas and focal nodular hyperplasia of the liver in young women on or", "tokenized_content": [2, 16787, 3, 6095, 16787, 1930, 8083, 21106, 13095, 1927, 1920, 3568, 1922, 4201, 3089, 1990, 2014, 3]}, "items": [{"id": "p_113", "content": "Adenoma [SEP] A benign epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16530, 3, 43, 8867, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_114", "content": "focal nodular hyperplasia [SEP] Hepatic adenomas and focal nodular hyperplasia of the liver in young women on oral contraceptives: case report", "tokenized_content": [2, 8083, 21106, 13095, 3, 6095, 16787, 1930, 8083, 21106, 13095, 1927, 1920, 3568, 1922, 4201, 3089, 1990, 4726, 25434, 30, 3087, 3809, 3]}, "items": [{"id": "p_114", "content": "Focal Nodular Hyperplasia [SEP] Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encaps", "score": 1, "type": null, "tokenized_content": [2, 8083, 21106, 13095, 3, 18992, 2014, 3137, 8867, 6095, 4541, 3861, 16, 5394, 6966, 1922, 3089, 1927, 2036, 17, 2761, 2739, 1927, 2632, 18, 1920, 17149, 16, 7865, 10771, 3]}]}
{"query": {"id": "q_115", "content": "oral contraceptives [SEP] as and focal nodular hyperplasia of the liver in young women on oral contraceptives: case reports.", "tokenized_content": [2, 4726, 25434, 3, 1966, 1930, 8083, 21106, 13095, 1927, 1920, 3568, 1922, 4201, 3089, 1990, 4726, 25434, 30, 3087, 4710, 18, 3]}, "items": [{"id": "p_115", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_116", "content": "adenoma [SEP] Two cases of hepatic adenoma and one of focal nodular hyperplasia presumably associated with", "tokenized_content": [2, 16530, 3, 2288, 2919, 1927, 6095, 16530, 1930, 2340, 1927, 8083, 21106, 13095, 9968, 2458, 1956, 3]}, "items": [{"id": "p_116", "content": "Adenoma [SEP] A benign epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16530, 3, 43, 8867, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_117", "content": "focal nodular hyperplasia [SEP] Two cases of hepatic adenoma and one of focal nodular hyperplasia presumably associated with the use of oral contraceptives, are ", "tokenized_content": [2, 8083, 21106, 13095, 3, 2288, 2919, 1927, 6095, 16530, 1930, 2340, 1927, 8083, 21106, 13095, 9968, 2458, 1956, 1920, 2485, 1927, 4726, 25434, 16, 2032, 3]}, "items": [{"id": "p_117", "content": "Focal Nodular Hyperplasia [SEP] Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encaps", "score": 1, "type": null, "tokenized_content": [2, 8083, 21106, 13095, 3, 18992, 2014, 3137, 8867, 6095, 4541, 3861, 16, 5394, 6966, 1922, 3089, 1927, 2036, 17, 2761, 2739, 1927, 2632, 18, 1920, 17149, 16, 7865, 10771, 3]}]}
{"query": {"id": "q_118", "content": "oral contraceptives [SEP] focal nodular hyperplasia presumably associated with the use of oral contraceptives, are reported. Special reference is made to their clinical pres", "tokenized_content": [2, 4726, 25434, 3, 8083, 21106, 13095, 9968, 2458, 1956, 1920, 2485, 1927, 4726, 25434, 16, 2032, 2568, 18, 5180, 4386, 1977, 3915, 1942, 2310, 2535, 2244, 3]}, "items": [{"id": "p_118", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_119", "content": "thromboembolism [SEP] Arterial thromboembolism in patients receiving systemic heparin therapy: a complication ", "tokenized_content": [2, 23821, 3, 6624, 23821, 1922, 2132, 5962, 5510, 9962, 3181, 30, 43, 9388, 3]}, "items": [{"id": "p_119", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_120", "content": "heparin [SEP] Arterial thromboembolism in patients receiving systemic heparin therapy: a complication associated with heparin-induced thrombo", "tokenized_content": [2, 9962, 3, 6624, 23821, 1922, 2132, 5962, 5510, 9962, 3181, 30, 43, 9388, 2458, 1956, 9962, 17, 2719, 16379, 3]}, "items": [{"id": "p_120", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_121", "content": "thrombocytopenia [SEP] heparin therapy: a complication associated with heparin-induced thrombocytopenia.", "tokenized_content": [2, 17100, 3, 9962, 3181, 30, 43, 9388, 2458, 1956, 9962, 17, 2719, 17100, 18, 3]}, "items": [{"id": "p_121", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_122", "content": "thromboembolism [SEP] Arterial thromboembolism is a recognized complication of systemic heparin therapy. Chara", "tokenized_content": [2, 23821, 3, 6624, 23821, 1977, 43, 6783, 9388, 1927, 5510, 9962, 3181, 18, 2618, 1019, 3]}, "items": [{"id": "p_122", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_123", "content": "heparin [SEP] terial thromboembolism is a recognized complication of systemic heparin therapy. Characteristic of the entity is arterial occlusion by ", "tokenized_content": [2, 9962, 3, 6005, 2086, 23821, 1977, 43, 6783, 9388, 1927, 5510, 9962, 3181, 18, 6293, 1927, 1920, 14866, 1977, 6624, 10543, 2007, 3]}, "items": [{"id": "p_123", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_124", "content": "arterial occlusion [SEP] on of systemic heparin therapy. Characteristic of the entity is arterial occlusion by platelet-fibrin thrombi with distal ischemia occurring four ", "tokenized_content": [2, 6624, 10543, 3, 1990, 1927, 5510, 9962, 3181, 18, 6293, 1927, 1920, 14866, 1977, 6624, 10543, 2007, 7163, 17, 9450, 5700, 1033, 1956, 6583, 7716, 6966, 3006, 3]}, "items": [{"id": "p_124", "content": "Arterial Occlusive Diseases [SEP] Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduce", "score": 1, "type": null, "tokenized_content": [2, 6624, 28715, 3902, 3, 6598, 4028, 2154, 3211, 1922, 1920, 5740, 2014, 4080, 10849, 1927, 9345, 18, 2611, 2032, 4378, 2007, 8138, 4412, 3]}]}
{"query": {"id": "q_125", "content": "thrombi [SEP] teristic of the entity is arterial occlusion by platelet-fibrin thrombi with distal ischemia occurring four to twenty days after the in", "tokenized_content": [2, 5700, 1033, 3, 6005, 4036, 1927, 1920, 14866, 1977, 6624, 10543, 2007, 7163, 17, 9450, 5700, 1033, 1956, 6583, 7716, 6966, 3006, 1942, 7639, 3000, 2256, 1920, 1922, 3]}, "items": [{"id": "p_125", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_126", "content": "ischemia [SEP] ty is arterial occlusion by platelet-fibrin thrombi with distal ischemia occurring four to twenty days after the initiation of heparin t", "tokenized_content": [2, 7716, 3, 6227, 1977, 6624, 10543, 2007, 7163, 17, 9450, 5700, 1033, 1956, 6583, 7716, 6966, 3006, 1942, 7639, 3000, 2256, 1920, 6035, 1927, 9962, 62, 3]}, "items": [{"id": "p_126", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_127", "content": "thrombocytopenia [SEP] s after the initiation of heparin therapy, preceded by profound thrombocytopenia with platelet counts in the range of 30,000 to 40,000 per cubic", "tokenized_content": [2, 17100, 3, 61, 2256, 1920, 6035, 1927, 9962, 3181, 16, 16757, 2007, 11098, 17100, 1956, 7163, 6965, 1922, 1920, 3109, 1927, 2627, 16, 3240, 1942, 3040, 16, 3240, 2079, 18816, 3]}, "items": [{"id": "p_127", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_128", "content": "musculoskeletal symptoms [SEP] ally apparent occlusion may be preceded by gastrointestinal and musculoskeletal symptoms that appear to be ischemic in origin, and might serve to warn t", "tokenized_content": [2, 15322, 3601, 3, 2136, 1012, 6273, 10543, 2278, 1998, 16757, 2007, 8375, 1930, 15322, 3601, 1988, 3267, 1942, 1998, 7427, 1922, 4853, 16, 1930, 3284, 7120, 1942, 8200, 1022, 62, 3]}, "items": [{"id": "p_128", "content": "Musculoskeletal Diseases [SEP] Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collect", "score": 1, "type": null, "tokenized_content": [2, 15322, 3902, 3, 3902, 1927, 1920, 7848, 1930, 2310, 2458, 27831, 1930, 2303, 14948, 2960, 1930, 1927, 1920, 14153, 1930, 8642, 11103, 11946, 3]}]}
{"query": {"id": "q_129", "content": "ischemic [SEP] gastrointestinal and musculoskeletal symptoms that appear to be ischemic in origin, and might serve to warn the clinician of these compl", "tokenized_content": [2, 7427, 3, 8375, 1930, 15322, 3601, 1988, 3267, 1942, 1998, 7427, 1922, 4853, 16, 1930, 3284, 7120, 1942, 8200, 1022, 1920, 12934, 1927, 2144, 6581, 3]}, "items": [{"id": "p_129", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_130", "content": "platelet aggregation [SEP] elating thromboembolism and thrombocytopenia is heparin-induced platelet aggregation. Appropriate treatment consists of discontinuation of heparin, ", "tokenized_content": [2, 7163, 7883, 3, 2349, 2287, 23821, 1930, 17100, 1977, 9962, 17, 2719, 7163, 7883, 18, 4703, 2311, 7543, 1927, 14775, 1927, 9962, 16, 3]}, "items": [{"id": "p_130", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_131", "content": "sodium warfarin [SEP] onsists of discontinuation of heparin, and anticoagulation with sodium warfarin if necessary. Vascular procedures are performed as indicated.", "tokenized_content": [2, 5227, 16170, 3, 24335, 3535, 1927, 14775, 1927, 9962, 16, 1930, 18331, 1956, 5227, 16170, 2647, 4680, 18, 4541, 4869, 2032, 2593, 1966, 3391, 18, 3]}, "items": [{"id": "p_131", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_132", "content": "paracetamol [SEP] Long-term prognosis for transplant-free survivors of paracetamol-induced acute liver failure.", "tokenized_content": [2, 27021, 3, 2815, 17, 2576, 6573, 1958, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4574, 18, 3]}, "items": [{"id": "p_132", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_133", "content": "acute liver failure [SEP]  prognosis for transplant-free survivors of paracetamol-induced acute liver failure.", "tokenized_content": [2, 3939, 3568, 4574, 3, 6573, 1958, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4574, 18, 3]}, "items": [{"id": "p_133", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_134", "content": "paracetamol [SEP] BACKGROUND: The prognosis for transplant-free survivors of paracetamol-induced acute liver failure remains unknown. AIM: To examine wh", "tokenized_content": [2, 27021, 3, 3872, 30, 1920, 6573, 1958, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4574, 4497, 5435, 18, 3774, 30, 1942, 5020, 2003, 3]}, "items": [{"id": "p_134", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_135", "content": "acute liver failure [SEP]  prognosis for transplant-free survivors of paracetamol-induced acute liver failure remains unknown. AIM: To examine whether paracetamol-induced ac", "tokenized_content": [2, 3939, 3568, 4574, 3, 6573, 1958, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4574, 4497, 5435, 18, 3774, 30, 1942, 5020, 3053, 27021, 17, 2719, 2000, 3]}, "items": [{"id": "p_135", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_136", "content": "acute liver injury [SEP] ollowed up all transplant-free survivors of paracetamol-induced acute liver injury, hospitalized in a Danish national referral centre during 1984-", "tokenized_content": [2, 3939, 3568, 4047, 3, 2865, 16496, 1919, 2353, 2136, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4047, 16, 13123, 1922, 43, 18247, 3852, 11033, 8141, 2409, 12812, 3]}, "items": [{"id": "p_136", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_137", "content": "liver injury [SEP] d up all transplant-free survivors of paracetamol-induced acute liver injury, hospitalized in a Danish national referral centre during 1984-", "tokenized_content": [2, 3568, 4047, 3, 46, 2353, 2136, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4047, 16, 13123, 1922, 43, 18247, 3852, 11033, 8141, 2409, 12812, 17, 3]}, "items": [{"id": "p_137", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_138", "content": "liver disease [SEP]  age-dependent, and no survivors of acute liver failure died of liver disease, whereas suicides were frequent in both groups. These observati", "tokenized_content": [2, 3568, 2573, 3, 2632, 17, 3100, 16, 1930, 2239, 9408, 1927, 3939, 3568, 4574, 8545, 1927, 3568, 2573, 16, 3417, 10064, 1036, 1985, 6439, 1922, 2321, 2671, 18, 2144, 3634, 3]}, "items": [{"id": "p_138", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_139", "content": "substance abuse [SEP] sulted from incomplete adjustment for the greater prevalence of substance abuse among survivors of acute liver failure. CONCLUSIONS: Paracetamo", "tokenized_content": [2, 7311, 7764, 3, 9596, 2013, 2037, 9876, 7970, 1958, 1920, 3430, 4077, 1927, 7311, 7764, 2706, 9408, 1927, 3939, 3568, 4574, 18, 4355, 30, 13344, 9215, 12492, 3]}, "items": [{"id": "p_139", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_140", "content": "Paracetamol [SEP] ance abuse among survivors of acute liver failure. CONCLUSIONS: Paracetamol-induced acute liver failure did not affect long-term mortality.", "tokenized_content": [2, 27021, 3, 10315, 1021, 7764, 2706, 9408, 1927, 3939, 3568, 4574, 18, 4355, 30, 27021, 17, 2719, 3939, 3568, 4574, 2811, 2084, 4081, 2815, 17, 2576, 3885, 18, 3]}, "items": [{"id": "p_140", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_141", "content": "liver failure [SEP] osis for transplant-free survivors of paracetamol-induced acute liver failure remains unknown. AIM: To examine whether paracetamol-induced ac", "tokenized_content": [2, 3568, 4574, 3, 3125, 1937, 1958, 5192, 17, 3294, 9408, 1927, 27021, 17, 2719, 3939, 3568, 4574, 4497, 5435, 18, 3774, 30, 1942, 5020, 3053, 27021, 17, 2719, 2000, 3]}, "items": [{"id": "p_141", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_142", "content": "Serotonin [SEP] Serotonin 6 receptor gene is associated with methamphetamine-induced psyc", "tokenized_content": [2, 11153, 3, 11153, 26, 3148, 2359, 1977, 2458, 1956, 20375, 17, 2719, 2742, 2773, 3]}, "items": [{"id": "p_142", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_143", "content": "methamphetamine [SEP] Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population.", "tokenized_content": [2, 20375, 3, 11153, 26, 3148, 2359, 1977, 2458, 1956, 20375, 17, 2719, 15489, 1922, 43, 10405, 2973, 18, 3]}, "items": [{"id": "p_143", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_144", "content": "psychosis [SEP] onin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population.", "tokenized_content": [2, 15489, 3, 1990, 1921, 26, 3148, 2359, 1977, 2458, 1956, 20375, 17, 2719, 15489, 1922, 43, 10405, 2973, 18, 3]}, "items": [{"id": "p_144", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_145", "content": "psychotic disorders [SEP]  transmission is hypothesized to be a susceptibility factor for psychotic disorders such as schizophrenia. The serotonin 6 (5-HT6) receptor is ther", "tokenized_content": [2, 16651, 4414, 3, 5303, 1977, 7149, 1942, 1998, 43, 6461, 2991, 1958, 16651, 4414, 2427, 1966, 7899, 18, 1920, 11153, 26, 12, 25, 17, 5334, 1016, 13, 3148, 1977, 2704, 3]}, "items": [{"id": "p_145", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_146", "content": "schizophrenia [SEP] d to be a susceptibility factor for psychotic disorders such as schizophrenia. The serotonin 6 (5-HT6) receptor is therapeutically targeted b", "tokenized_content": [2, 7899, 3, 46, 1942, 1998, 43, 6461, 2991, 1958, 16651, 4414, 2427, 1966, 7899, 18, 1920, 11153, 26, 12, 25, 17, 5334, 1016, 13, 3148, 1977, 25058, 5154, 44, 3]}, "items": [{"id": "p_146", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_147", "content": "serotonin [SEP] ility factor for psychotic disorders such as schizophrenia. The serotonin 6 (5-HT6) receptor is therapeutically targeted by several secon", "tokenized_content": [2, 11153, 3, 14872, 3145, 2991, 1958, 16651, 4414, 2427, 1966, 7899, 18, 1920, 11153, 26, 12, 25, 17, 5334, 1016, 13, 3148, 1977, 25058, 5154, 2007, 2980, 2532, 1916, 3]}, "items": [{"id": "p_147", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_148", "content": "5-HT [SEP] for psychotic disorders such as schizophrenia. The serotonin 6 (5-HT6) receptor is therapeutically targeted by several second genera", "tokenized_content": [2, 25, 17, 5334, 3, 1958, 16651, 4414, 2427, 1966, 7899, 18, 1920, 11153, 26, 12, 25, 17, 5334, 1016, 13, 3148, 1977, 25058, 5154, 2007, 2980, 2812, 12774, 3]}, "items": [{"id": "p_148", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_149", "content": "clozapine [SEP] y targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d-amphetamine-induced hyperactivity in rats", "tokenized_content": [2, 24424, 3, 67, 5154, 2007, 2980, 2812, 4841, 21474, 16, 2427, 1966, 24424, 1930, 26591, 16, 1930, 46, 17, 19057, 17, 2719, 15534, 1922, 3615, 3]}, "items": [{"id": "p_149", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_150", "content": "olanzapine [SEP] several second generation antipsychotics, such as clozapine and olanzapine, and d-amphetamine-induced hyperactivity in rats is corrected w", "tokenized_content": [2, 26591, 3, 2980, 2812, 4841, 21474, 16, 2427, 1966, 24424, 1930, 26591, 16, 1930, 46, 17, 19057, 17, 2719, 15534, 1922, 3615, 1977, 7702, 65, 3]}, "items": [{"id": "p_150", "content": "olanzapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26591, 3, 3]}]}
{"query": {"id": "q_151", "content": "d-amphetamine [SEP] eneration antipsychotics, such as clozapine and olanzapine, and d-amphetamine-induced hyperactivity in rats is corrected with the use of a se", "tokenized_content": [2, 46, 17, 19057, 3, 2066, 5026, 21474, 16, 2427, 1966, 24424, 1930, 26591, 16, 1930, 46, 17, 19057, 17, 2719, 15534, 1922, 3615, 1977, 7702, 1956, 1920, 2485, 1927, 43, 3]}, "items": [{"id": "p_151", "content": "Dextroamphetamine [SEP] The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatmen", "score": 1, "type": null, "tokenized_content": [2, 20256, 1931, 18996, 3, 1920, 46, 17, 2386, 1927, 19057, 18, 2176, 1977, 43, 4101, 7580, 2433, 24252, 1930, 43, 26638, 1947, 21870, 18, 2176, 2258, 2222, 2252, 2251, 1922, 1920, 2297, 19047, 3]}]}
{"query": {"id": "q_152", "content": "hyperactivity [SEP] cs, such as clozapine and olanzapine, and d-amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-HT6 receptor", "tokenized_content": [2, 15534, 3, 3752, 16, 2427, 1966, 24424, 1930, 26591, 16, 1930, 46, 17, 19057, 17, 2719, 15534, 1922, 3615, 1977, 7702, 1956, 1920, 2485, 1927, 43, 5328, 25, 17, 5334, 3]}, "items": [{"id": "p_152", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_153", "content": "phencyclidine [SEP] , the disrupted prepulse inhibition induced by d-amphetamine or phencyclidine was restored by 5-HT6 receptor antagonist in an animal study us", "tokenized_content": [2, 3037, 22170, 5802, 3, 16, 1920, 11138, 10719, 17765, 3523, 2719, 2007, 46, 17, 19057, 2014, 3037, 22170, 5802, 1982, 10680, 2007, 25, 17, 5334, 1016, 3148, 8151, 1922, 1925, 3]}, "items": [{"id": "p_153", "content": "Phencyclidine [SEP] A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is simila", "score": 1, "type": null, "tokenized_content": [2, 3037, 22170, 5802, 3, 43, 20958, 3522, 2432, 22397, 2251, 1966, 43, 15748, 16111, 16, 1930, 6699, 1966, 43, 3335, 16111, 1958, 5209, 18, 3037, 22170, 5802, 1977, 2328, 19167, 3]}]}
{"query": {"id": "q_154", "content": "methamphetamine [SEP]  in the pathophysiology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type ", "tokenized_content": [2, 20375, 3, 1922, 1920, 11985, 1927, 16651, 4414, 18, 1920, 3601, 1927, 20375, 12, 2295, 13, 17, 2719, 15489, 2032, 2551, 1942, 2690, 1927, 26124, 2642, 2601, 3]}, "items": [{"id": "p_154", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_155", "content": "METH [SEP] iology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizo", "tokenized_content": [2, 2295, 3, 23041, 2021, 1012, 1927, 16651, 4414, 18, 1920, 3601, 1927, 20375, 12, 2295, 13, 17, 2719, 15489, 2032, 2551, 1942, 2690, 1927, 26124, 2642, 2601, 7071, 1037, 3]}, "items": [{"id": "p_155", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_156", "content": "psychosis [SEP] hotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore,", "tokenized_content": [2, 15489, 3, 9529, 1935, 4414, 18, 1920, 3601, 1927, 20375, 12, 2295, 13, 17, 2719, 15489, 2032, 2551, 1942, 2690, 1927, 26124, 2642, 2601, 7899, 18, 2955, 16, 3]}, "items": [{"id": "p_156", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_157", "content": "paranoid type schizophrenia [SEP] ethamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the ", "tokenized_content": [2, 26124, 2642, 2601, 7899, 3, 3293, 18996, 12, 2295, 13, 17, 2719, 15489, 2032, 2551, 1942, 2690, 1927, 26124, 2642, 2601, 7899, 18, 2955, 16, 2038, 3609, 1925, 2333, 1927, 3]}, "items": [{"id": "p_157", "content": "Schizophrenia, Paranoid [SEP] A chronic form of schizophrenia characterized primarily by the presence of persecutory or grandiose delusions, often associated ", "score": 1, "type": null, "tokenized_content": [2, 7899, 16, 26124, 2642, 3, 43, 3724, 2386, 1927, 7899, 4378, 5985, 2007, 1920, 2990, 1927, 3096, 21065, 27708, 2014, 12038, 14356, 1021, 2723, 3910, 16, 3868, 2458, 3]}]}
{"query": {"id": "q_158", "content": "bupropion hydrochloride [SEP] Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice.", "tokenized_content": [2, 22955, 2928, 2001, 16675, 3, 2495, 1927, 3605, 13006, 7386, 3389, 1990, 22955, 2928, 2001, 16675, 17, 2719, 10060, 1922, 2518, 18, 3]}, "items": [{"id": "p_158", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_159", "content": "seizures [SEP] traperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice.", "tokenized_content": [2, 10060, 3, 10947, 18842, 5405, 5243, 7386, 3389, 1990, 22955, 2928, 2001, 16675, 17, 2719, 10060, 1922, 2518, 18, 3]}, "items": [{"id": "p_159", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_160", "content": "bupropion [SEP]  if there is a relationship between input rate and incidence of bupropion-induced seizures. This is important, since different controlled", "tokenized_content": [2, 22955, 2928, 2001, 3, 2647, 2276, 1977, 43, 3303, 2192, 5877, 2769, 1930, 4332, 1927, 22955, 2928, 2001, 17, 2719, 10060, 18, 2052, 1977, 2715, 16, 3328, 2413, 4642, 3]}, "items": [{"id": "p_160", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_161", "content": "seizures [SEP] ationship between input rate and incidence of bupropion-induced seizures. This is important, since different controlled release formulat", "tokenized_content": [2, 10060, 3, 2019, 2443, 3050, 2192, 5877, 2769, 1930, 4332, 1927, 22955, 2928, 2001, 17, 2719, 10060, 18, 2052, 1977, 2715, 16, 3328, 2413, 4642, 4012, 9378, 1031, 3]}, "items": [{"id": "p_161", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_162", "content": "bupropion HCl [SEP] ted the effect of varying the intraperitoneal infusion rates of bupropion HCl 120 mg/kg, a known convulsive dose 50 (CD50), on the incidence ", "tokenized_content": [2, 22955, 2928, 2001, 7833, 3, 26080, 1920, 2495, 1927, 7155, 1920, 13006, 7386, 3389, 1927, 22955, 2928, 2001, 7833, 6103, 2786, 19, 3621, 16, 43, 3171, 4772, 13042, 3253, 2761, 3]}, "items": [{"id": "p_162", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_163", "content": "convulsive [SEP] raperitoneal infusion rates of bupropion HCl 120 mg/kg, a known convulsive dose 50 (CD50), on the incidence and severity of bupropion-indu", "tokenized_content": [2, 4772, 13042, 3, 30497, 3027, 5405, 5243, 7386, 3389, 1927, 22955, 2928, 2001, 7833, 6103, 2786, 19, 3621, 16, 43, 3171, 4772, 13042, 3253, 2761, 12, 27344, 1008, 13, 16, 3]}, "items": [{"id": "p_163", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_164", "content": "convulsions [SEP] e 50 (CD50), on the incidence and severity of bupropion-induced convulsions in the Swiss albino mice. A total of 69 mice, approximately 7 w", "tokenized_content": [2, 4772, 19389, 3, 47, 2761, 12, 27344, 1008, 13, 16, 1990, 1920, 4332, 1930, 5155, 1927, 22955, 2928, 2001, 17, 2719, 4772, 19389, 1922, 1920, 15412, 28734, 2518, 18, 43, 3]}, "items": [{"id": "p_164", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_165", "content": "Bupropion HCl [SEP] al (IP) administration in 7 groups (9 to 10 animals per group). Bupropion HCl was infused through a surgically implanted IP dosing catheter w", "tokenized_content": [2, 22955, 2928, 2001, 7833, 3, 1969, 12, 5416, 13, 4183, 1922, 27, 2671, 12, 29, 1942, 2119, 3555, 2079, 2210, 13, 18, 22955, 2928, 2001, 7833, 1982, 15610, 2596, 43, 3]}, "items": [{"id": "p_165", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_166", "content": "penicillin [SEP] Detailed spectral profile analysis of penicillin-induced epileptiform activity in anesthetized rats.", "tokenized_content": [2, 9957, 3, 5720, 8133, 5174, 2333, 1927, 9957, 17, 2719, 28367, 6154, 2455, 1922, 12137, 3615, 18, 3]}, "items": [{"id": "p_166", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_167", "content": "epileptiform activity [SEP] Detailed spectral profile analysis of penicillin-induced epileptiform activity in anesthetized rats.", "tokenized_content": [2, 28367, 6154, 2455, 3, 5720, 8133, 5174, 2333, 1927, 9957, 17, 2719, 28367, 6154, 2455, 1922, 12137, 3615, 18, 3]}, "items": [{"id": "p_167", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_168", "content": "Penicillin [SEP] Penicillin model is a widely used experimental model for epilepsy research", "tokenized_content": [2, 9957, 3, 9957, 2322, 1977, 43, 5673, 2251, 3599, 2322, 1958, 9741, 2659, 3]}, "items": [{"id": "p_168", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_169", "content": "epilepsy [SEP] Penicillin model is a widely used experimental model for epilepsy research. In the present study we aimed to portray a detailed s", "tokenized_content": [2, 9741, 3, 9957, 2322, 1977, 43, 5673, 2251, 3599, 2322, 1958, 9741, 2659, 18, 1922, 1920, 2481, 2161, 2038, 6822, 1942, 30254, 2050, 43, 5720, 61, 3]}, "items": [{"id": "p_169", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_170", "content": "penicillin [SEP] esent study we aimed to portray a detailed spectral analysis of penicillin-induced epileptiform activity in comparison with basal brain ac", "tokenized_content": [2, 9957, 3, 2376, 1939, 2161, 2038, 6822, 1942, 30254, 2050, 43, 5720, 8133, 2333, 1927, 9957, 17, 2719, 28367, 6154, 2455, 1922, 3723, 1956, 5342, 3068, 2000, 3]}, "items": [{"id": "p_170", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_171", "content": "epileptiform activity [SEP] d to portray a detailed spectral analysis of penicillin-induced epileptiform activity in comparison with basal brain activity in anesthetized Wistar ", "tokenized_content": [2, 28367, 6154, 2455, 3, 46, 1942, 30254, 2050, 43, 5720, 8133, 2333, 1927, 9957, 17, 2719, 28367, 6154, 2455, 1922, 3723, 1956, 5342, 3068, 2455, 1922, 12137, 15668, 3]}, "items": [{"id": "p_171", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_172", "content": "urethane [SEP] tized Wistar rats. Male Wistar rats were anesthetized with i.p. urethane and connected to an electrocorticogram setup. After a short per", "tokenized_content": [2, 19221, 2516, 3, 8685, 6756, 15668, 3615, 18, 4005, 15668, 3615, 1985, 12137, 1956, 51, 18, 58, 18, 19221, 2516, 1930, 7951, 1942, 1925, 13142, 5994, 7539, 13037, 18, 2256, 3]}, "items": [{"id": "p_172", "content": "Urethane [SEP] Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis", "score": 1, "type": null, "tokenized_content": [2, 19221, 2516, 3, 29128, 9969, 5899, 1988, 1977, 2222, 2251, 1966, 43, 15748, 16111, 18, 2176, 2258, 2222, 2252, 2251, 1966, 1925, 6129, 1922, 6805, 4271, 3]}]}
{"query": {"id": "q_173", "content": "epileptic [SEP] cogram setup. After a short period of basal activity recording, epileptic focus was induced by injecting 400IU/2 microl penicillin-G pota", "tokenized_content": [2, 16304, 3, 17082, 29085, 13037, 18, 2256, 43, 3662, 3047, 1927, 5342, 2455, 6340, 16, 16304, 3691, 1982, 2719, 2007, 18248, 5805, 1033, 1032, 19, 22, 16262, 9957, 17, 49, 3]}, "items": [{"id": "p_173", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_174", "content": "penicillin-G potassium [SEP] ording, epileptic focus was induced by injecting 400IU/2 microl penicillin-G potassium into the left lateral ventricle while the cortical activity was", "tokenized_content": [2, 9957, 17, 49, 9057, 3, 8873, 1941, 16, 16304, 3691, 1982, 2719, 2007, 18248, 5805, 1033, 1032, 19, 22, 16262, 9957, 17, 49, 9057, 2460, 1920, 3506, 5347, 11887, 2679, 3]}, "items": [{"id": "p_174", "content": "Penicillin G [SEP] A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. ", "score": 1, "type": null, "tokenized_content": [2, 9957, 49, 3, 43, 9957, 10533, 5384, 2251, 1922, 1920, 2386, 1927, 2496, 5227, 2014, 9057, 16028, 1922, 1920, 2311, 1927, 43, 5386, 1927, 5024, 18, 3]}]}
{"query": {"id": "q_175", "content": "epilepsies [SEP] basic neuronal mechanism of this or other types of experimental epilepsies.", "tokenized_content": [2, 7812, 2523, 2062, 3, 5937, 5121, 2856, 1927, 2052, 2014, 2303, 3584, 1927, 3599, 7812, 2523, 2062, 18, 3]}, "items": [{"id": "p_175", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_176", "content": "dexmedetomidine [SEP] High dose dexmedetomidine as the sole sedative for pediatric MRI.", "tokenized_content": [2, 26854, 3, 2149, 3253, 26854, 1966, 1920, 12168, 28514, 1958, 7460, 5371, 18, 3]}, "items": [{"id": "p_176", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_177", "content": "dexmedetomidine [SEP] ge-scale retrospective review evaluates the sedation profile of dexmedetomidine. AIM: To determine the hemodynamic responses, efficacy and adve", "tokenized_content": [2, 26854, 3, 3929, 17, 3536, 6968, 3043, 22494, 1920, 15263, 5174, 1927, 26854, 18, 3774, 30, 1942, 3415, 1920, 12173, 3387, 16, 4348, 1930, 3277, 1021, 3]}, "items": [{"id": "p_177", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_178", "content": "Dexmedetomidine [SEP] ative for magnetic resonance imaging (MRI) studies. BACKGROUND: Dexmedetomidine has been used at our institution since 2005 to provide sedation", "tokenized_content": [2, 26854, 3, 2019, 2320, 1958, 5691, 6912, 3755, 12, 5371, 13, 2351, 18, 3872, 30, 26854, 2258, 2252, 2251, 2019, 2342, 5115, 3328, 4083, 1942, 3394, 15263, 3]}, "items": [{"id": "p_178", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_179", "content": "pentobarbital [SEP] .8% to 97.6% (P = 0.009), reducing the requirement for adjuvant pentobarbital in the event of sedation failure with dexmedetomidine alone and", "tokenized_content": [2, 23271, 3, 18, 28, 9, 1942, 5749, 18, 26, 9, 12, 58, 33, 20, 18, 14838, 13, 16, 5526, 1920, 8853, 1958, 8968, 23271, 1922, 1920, 4817, 1927, 15263, 4574, 3]}, "items": [{"id": "p_179", "content": "Pentobarbital [SEP] A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given ", "score": 1, "type": null, "tokenized_content": [2, 23271, 3, 43, 3662, 17, 8290, 30434, 4219, 5524, 2057, 1988, 1977, 3655, 1966, 43, 28514, 1930, 25810, 3153, 12, 2308, 2084, 1966, 1925, 2246, 17, 5592, 13, 5899, 1930, 1977, 5394, 3258, 3]}]}
{"query": {"id": "q_180", "content": "bradycardia [SEP] dexmedetomidine sedation was associated with a 16% incidence of bradycardia, all concomitant mean arterial blood pressures were within 20% ", "tokenized_content": [2, 26192, 3, 26854, 15263, 1982, 2458, 1956, 43, 2641, 9, 4332, 1927, 26192, 16, 2136, 8537, 2667, 6624, 2877, 11704, 1985, 2651, 2036, 9, 3]}, "items": [{"id": "p_180", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_181", "content": "oxygen [SEP] lood pressures were within 20% of age-adjusted normal range and oxygen saturations were 95% or higher. CONCLUSION: Dexmedetomidine in ", "tokenized_content": [2, 4612, 3, 3004, 1986, 11704, 1985, 2651, 2036, 9, 1927, 2632, 17, 4967, 2791, 3109, 1930, 4612, 10113, 1036, 1985, 3002, 9, 2014, 2580, 18, 4180, 30, 26854, 1922, 3]}, "items": [{"id": "p_181", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_182", "content": "Methamphetamine [SEP] Methamphetamine causes alterations in the MAP kinase-related pathways in the br", "tokenized_content": [2, 20375, 3, 20375, 5092, 5996, 1922, 1920, 4446, 4016, 17, 2712, 3873, 1922, 1920, 2387, 3]}, "items": [{"id": "p_182", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_183", "content": "aggressiveness [SEP] e-related pathways in the brains of mice that display increased aggressiveness.", "tokenized_content": [2, 23161, 3, 47, 17, 2712, 3873, 1922, 1920, 9831, 1927, 2518, 1988, 4434, 2502, 23161, 18, 3]}, "items": [{"id": "p_183", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_184", "content": "Aggressive behaviors [SEP] Aggressive behaviors have been reported in patients who suffer from some psychiatric", "tokenized_content": [2, 8704, 5888, 3, 8704, 5888, 2162, 2252, 2568, 1922, 2132, 2746, 7416, 2037, 2673, 7652, 3]}, "items": [{"id": "p_184", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_185", "content": "psychiatric disorders [SEP] e behaviors have been reported in patients who suffer from some psychiatric disorders, and are common in methamphetamine (METH) abusers. Herein, we r", "tokenized_content": [2, 7652, 4414, 3, 47, 5888, 2162, 2252, 2568, 1922, 2132, 2746, 7416, 2037, 2673, 7652, 4414, 16, 1930, 2032, 3059, 1922, 20375, 12, 2295, 13, 7764, 5675, 18, 10388, 16, 3]}, "items": [{"id": "p_185", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_186", "content": "methamphetamine [SEP] s who suffer from some psychiatric disorders, and are common in methamphetamine (METH) abusers. Herein, we report that multiple (but not single", "tokenized_content": [2, 20375, 3, 61, 2746, 7416, 2037, 2673, 7652, 4414, 16, 1930, 2032, 3059, 1922, 20375, 12, 2295, 13, 7764, 5675, 18, 10388, 16, 2038, 3809, 1988, 3137, 12, 2308, 2084, 3]}, "items": [{"id": "p_186", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_187", "content": "METH [SEP]  some psychiatric disorders, and are common in methamphetamine (METH) abusers. Herein, we report that multiple (but not single) inje", "tokenized_content": [2, 2295, 3, 2673, 7652, 4414, 16, 1930, 2032, 3059, 1922, 20375, 12, 2295, 13, 7764, 5675, 18, 10388, 16, 2038, 3809, 1988, 3137, 12, 2308, 2084, 2957, 13, 2831, 1021, 3]}, "items": [{"id": "p_187", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_188", "content": "aggressiveness [SEP] ple (but not single) injections of METH significantly increased aggressiveness in male CD-1 mice. This increase in aggressiveness was not seco", "tokenized_content": [2, 23161, 3, 6483, 12, 2308, 2084, 2957, 13, 8775, 1927, 2295, 2567, 2502, 23161, 1922, 4005, 2464, 17, 21, 2518, 18, 2052, 2760, 1922, 23161, 1982, 2084, 2532, 1037, 3]}, "items": [{"id": "p_188", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_189", "content": "hyperactivity [SEP] is increase in aggressiveness was not secondary to METH-induced hyperactivity. Analysis of protein expression using antibody microarrays and ", "tokenized_content": [2, 15534, 3, 1977, 2760, 1922, 23161, 1982, 2084, 4067, 1942, 2295, 17, 2719, 15534, 18, 2333, 1927, 2213, 2294, 2193, 3533, 15913, 1930, 3]}, "items": [{"id": "p_189", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_190", "content": "aggressive behaviors [SEP] -striatal circuitries might be involved in the manifestation of aggressive behaviors in mice.", "tokenized_content": [2, 8704, 5888, 3, 17, 13165, 10999, 25921, 3284, 1998, 3286, 1922, 1920, 15570, 1927, 8704, 5888, 1922, 2518, 18, 3]}, "items": [{"id": "p_190", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_191", "content": "Lamotrigine [SEP] Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic", "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 8282, 18935, 26296, 1021, 2458, 1956, 17021, 2014, 2028, 9441, 15924, 2223, 1916, 1957, 1922, 13513, 3]}, "items": [{"id": "p_191", "content": "lamotrigine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 3]}]}
{"query": {"id": "q_192", "content": "myoclonus [SEP] Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 8282, 18935, 26296, 1021, 2458, 1956, 17021, 2014, 2028, 9441, 15924, 2223, 1916, 1957, 1922, 13513, 9612, 7812, 2523, 2062, 18, 3]}, "items": [{"id": "p_192", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_193", "content": "idiopathic generalized epilepsies [SEP] amotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.", "tokenized_content": [2, 13513, 9612, 7812, 2523, 2062, 3, 2150, 18935, 26296, 1021, 2458, 1956, 17021, 2014, 2028, 9441, 15924, 2223, 1916, 1957, 1922, 13513, 9612, 7812, 2523, 2062, 18, 3]}, "items": [{"id": "p_193", "content": "Epilepsy, Idiopathic Generalized [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 13513, 9612, 3, 3]}]}
{"query": {"id": "q_194", "content": "idiopathic generalized epilepsies [SEP] Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation o", "tokenized_content": [2, 13513, 9612, 7812, 2523, 2062, 3, 3628, 2132, 1956, 13513, 9612, 7812, 2523, 2062, 12, 10777, 13, 2868, 1956, 8282, 18935, 26296, 1021, 12, 3457, 1029, 13, 6090, 17021, 57, 3]}, "items": [{"id": "p_194", "content": "Epilepsy, Idiopathic Generalized [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 13513, 9612, 3, 3]}]}
{"query": {"id": "q_195", "content": "IGE [SEP] Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de ", "tokenized_content": [2, 10777, 3, 3628, 2132, 1956, 13513, 9612, 7812, 2523, 2062, 12, 10777, 13, 2868, 1956, 8282, 18935, 26296, 1021, 12, 3457, 1029, 13, 6090, 17021, 2014, 2028, 3]}, "items": [{"id": "p_195", "content": "Epilepsy, Idiopathic Generalized [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 13513, 9612, 3, 3]}]}
{"query": {"id": "q_196", "content": "lamotrigine [SEP] ients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclon", "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 10116, 4905, 1036, 1956, 13513, 9612, 7812, 2523, 2062, 12, 10777, 13, 2868, 1956, 8282, 18935, 26296, 1021, 12, 3457, 1029, 13, 6090, 17021, 2014, 3]}, "items": [{"id": "p_196", "content": "lamotrigine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 3]}]}
{"query": {"id": "q_197", "content": "LTG [SEP] iopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic je", "tokenized_content": [2, 3457, 1029, 3, 12906, 21494, 9612, 7812, 2523, 2062, 12, 10777, 13, 2868, 1956, 8282, 18935, 26296, 1021, 12, 3457, 1029, 13, 6090, 17021, 2014, 2028, 9441, 7818, 1927, 15924, 3]}, "items": [{"id": "p_197", "content": "lamotrigine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 3]}]}
{"query": {"id": "q_198", "content": "myoclonic jerks [SEP] trigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent", "tokenized_content": [2, 15924, 2223, 3490, 26482, 5297, 3, 4752, 2053, 12, 3457, 1029, 13, 6090, 17021, 2014, 2028, 9441, 7818, 1927, 15924, 2223, 3490, 26482, 5297, 12, 15697, 13, 18, 1922, 2559, 3]}, "items": [{"id": "p_198", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_199", "content": "MJ [SEP] erienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent man", "tokenized_content": [2, 15697, 3, 2668, 11741, 1007, 17021, 2014, 2028, 9441, 7818, 1927, 15924, 2223, 3490, 26482, 5297, 12, 15697, 13, 18, 1922, 2559, 2132, 16, 3457, 1029, 19159, 15697, 1922, 43, 3]}, "items": [{"id": "p_199", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_200", "content": "myoclonic status [SEP] s, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.", "tokenized_content": [2, 15924, 2223, 3490, 3642, 3, 61, 16, 3457, 1029, 19159, 15697, 1922, 43, 7083, 2308, 2253, 4010, 5222, 16, 1956, 15924, 2223, 3490, 3642, 1988, 2444, 14292, 4127, 1007, 2256, 3]}, "items": [{"id": "p_200", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_201", "content": "dyskinesias [SEP] rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease.", "tokenized_content": [2, 3890, 26682, 1036, 3, 23443, 1927, 3768, 4842, 3403, 13112, 3181, 17, 2719, 3890, 26682, 1036, 1922, 10124, 2573, 18, 3]}, "items": [{"id": "p_201", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_202", "content": "Parkinson disease [SEP] pplementary motor area modulates therapy-induced dyskinesias in Parkinson disease.", "tokenized_content": [2, 10124, 2573, 3, 4108, 1952, 2017, 2141, 4842, 3403, 13112, 3181, 17, 2719, 3890, 26682, 1036, 1922, 10124, 2573, 18, 3]}, "items": [{"id": "p_202", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_203", "content": "levodopa [SEP] The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial m", "tokenized_content": [2, 26723, 3, 1920, 5181, 3531, 1930, 18459, 3286, 1922, 26723, 17, 2719, 3890, 26682, 2032, 6390, 18, 2193, 12089, 23916, 55, 3]}, "items": [{"id": "p_203", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_204", "content": "dyskinesia [SEP] he neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation", "tokenized_content": [2, 3890, 26682, 3, 2234, 5181, 3531, 1930, 18459, 3286, 1922, 26723, 17, 2719, 3890, 26682, 2032, 6390, 18, 2193, 12089, 23916, 5691, 4177, 3]}, "items": [{"id": "p_204", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_205", "content": "Parkinson disease [SEP] lementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitabilit", "tokenized_content": [2, 10124, 2573, 3, 15551, 10653, 6907, 4842, 3403, 12, 11953, 13, 1922, 43, 2210, 1927, 2132, 1956, 5570, 10124, 2573, 16, 1920, 3875, 3845, 3053, 7145, 1927, 11953, 7817, 3836, 3]}, "items": [{"id": "p_205", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_206", "content": "dyskinetic [SEP] odulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz ", "tokenized_content": [2, 3890, 24590, 2002, 3, 4426, 2281, 1927, 11953, 14670, 2278, 3211, 1922, 43, 6295, 1927, 43, 3890, 24590, 2002, 3360, 2719, 2007, 4798, 11466, 12492, 11119, 7969, 2912, 7386, 18, 3]}, "items": [{"id": "p_206", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_207", "content": "apomorphine [SEP] t in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-ind", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 62, 1922, 43, 6295, 1927, 43, 3890, 24590, 2002, 3360, 2719, 2007, 4798, 11466, 12492, 11119, 7969, 2912, 7386, 18, 23443, 2019, 21, 4865, 3]}, "items": [{"id": "p_207", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_208", "content": "drug-induced dyskinesias [SEP] morphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increas", "tokenized_content": [2, 2838, 17, 2719, 3890, 26682, 1036, 3, 11553, 7386, 18, 23443, 2019, 21, 4865, 1982, 2528, 1942, 7686, 4412, 2838, 17, 2719, 3890, 26682, 1036, 16, 3417, 25, 17, 4865, 3]}, "items": [{"id": "p_208", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_209", "content": "amnesia [SEP] Assessment of the onset and persistence of amnesia during procedural sedation with propofol.", "tokenized_content": [2, 14701, 7156, 3, 4076, 1927, 1920, 4727, 1930, 10804, 1927, 14701, 7156, 2409, 17042, 15263, 1956, 16615, 18, 3]}, "items": [{"id": "p_209", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_210", "content": "propofol [SEP] nset and persistence of amnesia during procedural sedation with propofol.", "tokenized_content": [2, 16615, 3, 28686, 1031, 1930, 10804, 1927, 14701, 7156, 2409, 17042, 15263, 1956, 16615, 18, 3]}, "items": [{"id": "p_210", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_211", "content": "propofol [SEP] rds presented to them while undergoing procedural sedation with propofol, and correlate their recall with their level of awareness as me", "tokenized_content": [2, 16615, 3, 25503, 3549, 1942, 3581, 2679, 7258, 17042, 15263, 1956, 16615, 16, 1930, 8474, 2310, 8717, 1956, 2310, 2237, 1927, 8755, 1966, 2142, 3]}, "items": [{"id": "p_211", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_212", "content": "inability to repeat words [SEP]  74.3 to 80.0). The mean highest BIS score corresponding to the inability to repeat words was 81.5 (95% CI = 78.1 to 84.8). The mean BIS score correspond", "tokenized_content": [2, 11752, 1942, 6865, 6906, 3, 5446, 18, 23, 1942, 3729, 18, 20, 13, 18, 1920, 2667, 4554, 7266, 3593, 3980, 1942, 1920, 11752, 1942, 6865, 6906, 1982, 6206, 18, 25, 3]}, "items": [{"id": "p_212", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_213", "content": "retrograde amnesia [SEP] associated with recall after procedural sedation, suggestive of retrograde amnesia.", "tokenized_content": [2, 14492, 14701, 7156, 3, 2458, 1956, 8717, 2256, 17042, 15263, 16, 12855, 1927, 14492, 14701, 7156, 18, 3]}, "items": [{"id": "p_213", "content": "Amnesia, Retrograde [SEP] Loss of the ability to recall information that had been previously encoded in memory prior to a specified or approximate point i", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 16, 14492, 3, 3257, 1927, 1920, 3682, 1942, 8717, 2988, 1988, 2430, 2252, 3024, 7905, 1922, 4525, 3432, 1942, 43, 9296, 2014, 12543, 3575, 51, 3]}]}
{"query": {"id": "q_214", "content": "hepatitis B [SEP] Assessment of perinatal hepatitis B and rubella prevention in New Hampshire delivery hospitals.", "tokenized_content": [2, 7977, 44, 3, 4076, 1927, 13833, 7977, 44, 1930, 10010, 5870, 5455, 1922, 2814, 8616, 2523, 25579, 4868, 7252, 18, 3]}, "items": [{"id": "p_214", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_215", "content": "rubella [SEP] Assessment of perinatal hepatitis B and rubella prevention in New Hampshire delivery hospitals.", "tokenized_content": [2, 10010, 5870, 3, 4076, 1927, 13833, 7977, 44, 1930, 10010, 5870, 5455, 1922, 2814, 8616, 2523, 25579, 4868, 7252, 18, 3]}, "items": [{"id": "p_215", "content": "Rubella [SEP] An acute infectious disease caused by the RUBELLA VIRUS. The virus enters the respiratory tract via airborne droplet and spreads", "score": 1, "type": null, "tokenized_content": [2, 10010, 5870, 3, 1925, 3939, 7465, 2573, 4189, 2007, 1920, 10010, 5870, 3413, 18, 1920, 3413, 21025, 1920, 5481, 6482, 3454, 24912, 10622, 1930, 21322, 3]}]}
{"query": {"id": "q_216", "content": "hepatitis B [SEP] CTIVE: To evaluate current performance on recommended perinatal hepatitis B and rubella prevention practices in New Hampshire. METHODS: Dat", "tokenized_content": [2, 7977, 44, 3, 3369, 2320, 30, 1942, 4323, 3214, 3604, 1990, 6198, 13833, 7977, 44, 1930, 10010, 5870, 5455, 7300, 1922, 2814, 8616, 2523, 25579, 18, 2860, 30, 2181, 3]}, "items": [{"id": "p_216", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_217", "content": "rubella [SEP] te current performance on recommended perinatal hepatitis B and rubella prevention practices in New Hampshire. METHODS: Data were extra", "tokenized_content": [2, 10010, 5870, 3, 3602, 3214, 3604, 1990, 6198, 13833, 7977, 44, 1930, 10010, 5870, 5455, 7300, 1922, 2814, 8616, 2523, 25579, 18, 2860, 30, 2230, 1985, 8324, 3]}, "items": [{"id": "p_217", "content": "Rubella [SEP] An acute infectious disease caused by the RUBELLA VIRUS. The virus enters the respiratory tract via airborne droplet and spreads", "score": 1, "type": null, "tokenized_content": [2, 10010, 5870, 3, 1925, 3939, 7465, 2573, 4189, 2007, 1920, 10010, 5870, 3413, 18, 1920, 3413, 21025, 1920, 5481, 6482, 3454, 24912, 10622, 1930, 21322, 3]}]}
{"query": {"id": "q_218", "content": "hepatitis B surface antigen [SEP] tion of hepatitis B immune globulin to infants who were born to hepatitis B surface antigen-positive mothers, rubella immunity, and administration of in-ho", "tokenized_content": [2, 7977, 44, 3154, 4730, 3, 8685, 1916, 1927, 7977, 44, 3743, 24366, 1942, 5969, 2746, 1985, 8813, 1942, 7977, 44, 3154, 4730, 17, 2843, 7026, 16, 10010, 5870, 7611, 16, 3]}, "items": [{"id": "p_218", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_219", "content": "Hepatitis B [SEP] ng rates for hepatitis B (98.8%) and rubella (99.4%) were high. Hepatitis B vaccine birth dose was administered to 76.2% of all infants. Al", "tokenized_content": [2, 7977, 44, 3, 4375, 3389, 1958, 7977, 44, 12, 5613, 18, 28, 9, 13, 1930, 10010, 5870, 12, 4922, 18, 24, 9, 13, 1985, 2149, 18, 7977, 44, 5955, 5043, 3]}, "items": [{"id": "p_219", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_220", "content": "Doxorubicin [SEP] Doxorubicin is an anti-tumor agent that represses cardiac-specific gene exp", "tokenized_content": [2, 12377, 3, 12377, 1977, 1925, 2246, 17, 2798, 5899, 1988, 21688, 4435, 17, 2487, 2359, 2887, 3]}, "items": [{"id": "p_220", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_221", "content": "tumor [SEP] Doxorubicin is an anti-tumor agent that represses cardiac-specific gene expression and induc", "tokenized_content": [2, 2798, 3, 12377, 1977, 1925, 2246, 17, 2798, 5899, 1988, 21688, 4435, 17, 2487, 2359, 2294, 1930, 4320, 3]}, "items": [{"id": "p_221", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_222", "content": "doxorubicin [SEP] rdiac myocytes. However, the role of p300 in protection against doxorubicin-induced apoptosis is unknown. Transgenic mice overexpressing p3", "tokenized_content": [2, 12377, 3, 8695, 2126, 1030, 14680, 18, 2406, 16, 1920, 2770, 1927, 14793, 1922, 6202, 3316, 12377, 17, 2719, 4091, 1977, 5435, 18, 6309, 2518, 10785, 9234, 3]}, "items": [{"id": "p_222", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_223", "content": "heart failure [SEP] m doxorubicin-induced apoptosis and reduces the extent of acute heart failure in adult mice in vivo.", "tokenized_content": [2, 4003, 4574, 3, 55, 12377, 17, 2719, 4091, 1930, 7268, 1920, 5064, 1927, 3939, 4003, 4574, 1922, 4160, 2518, 1922, 3597, 18, 3]}, "items": [{"id": "p_223", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_224", "content": "doxorubicin [SEP] ondrial DNA and its respiratory chain products are defective in doxorubicin nephrosis.", "tokenized_content": [2, 12377, 3, 1990, 3883, 2086, 2678, 1930, 2496, 5481, 4659, 4461, 2032, 9785, 1922, 12377, 7737, 4870, 18, 3]}, "items": [{"id": "p_224", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_225", "content": "nephrosis [SEP] and its respiratory chain products are defective in doxorubicin nephrosis.", "tokenized_content": [2, 7737, 4870, 3, 1930, 2496, 5481, 4659, 4461, 2032, 9785, 1922, 12377, 7737, 4870, 18, 3]}, "items": [{"id": "p_225", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_226", "content": "Doxorubicin [SEP] BACKGROUND: Doxorubicin induces a self-perpetuating nephropathy characterized by early ", "tokenized_content": [2, 12377, 3, 3872, 30, 12377, 6387, 43, 3543, 17, 26857, 12169, 2104, 15582, 4378, 2007, 3120, 3]}, "items": [{"id": "p_226", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_227", "content": "nephropathy [SEP] BACKGROUND: Doxorubicin induces a self-perpetuating nephropathy characterized by early glomerular and late-onset tubular lesion", "tokenized_content": [2, 15582, 3, 3872, 30, 12377, 6387, 43, 3543, 17, 26857, 12169, 2104, 15582, 4378, 2007, 3120, 11655, 1930, 5058, 17, 4727, 11755, 5709, 3]}, "items": [{"id": "p_227", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_228", "content": "glomerular and late-onset tubular lesions [SEP]  induces a self-perpetuating nephropathy characterized by early glomerular and late-onset tubular lesions in rats. We investigated the potential role of mitochondrial in", "tokenized_content": [2, 11655, 1930, 5058, 17, 4727, 11755, 4518, 3, 6387, 43, 3543, 17, 26857, 12169, 2104, 15582, 4378, 2007, 3120, 11655, 1930, 5058, 17, 4727, 11755, 4518, 1922, 3615, 18, 2038, 3]}, "items": [{"id": "p_228", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_229", "content": "mitochondrial injury [SEP]  tubular lesions in rats. We investigated the potential role of mitochondrial injury in the onset of these lesions. METHODS: Rats were treated with ", "tokenized_content": [2, 4596, 4047, 3, 11755, 4518, 1922, 3615, 18, 2038, 3845, 1920, 2889, 2770, 1927, 4596, 4047, 1922, 1920, 4727, 1927, 2144, 4518, 18, 2860, 30, 3615, 1985, 2868, 1956, 3]}, "items": [{"id": "p_229", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_230", "content": "doxorubicin [SEP] t of these lesions. METHODS: Rats were treated with intravenous doxorubicin (1 mg kg(-1) week(-1)) for 7 weeks and were sacrificed either 1", "tokenized_content": [2, 12377, 3, 62, 1927, 2144, 4518, 18, 2860, 30, 3615, 1985, 2868, 1956, 7307, 12377, 12, 21, 2786, 3621, 12, 17, 21, 13, 2982, 12, 17, 21, 13, 13, 1958, 3]}, "items": [{"id": "p_230", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_231", "content": "Glomerular and tubular injury [SEP] h prior to euthanasia. All rats were killed at 48 weeks of age. Glomerular and tubular injury was monitored and correlated to the activity or expression of r", "tokenized_content": [2, 11655, 1930, 11755, 4047, 3, 50, 3432, 1942, 25592, 18, 2136, 3615, 1985, 13666, 2019, 3427, 3625, 1927, 2632, 18, 11655, 1930, 11755, 4047, 1982, 7027, 1930, 4374, 1942, 1920, 3]}, "items": [{"id": "p_231", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_232", "content": "superoxide [SEP] uantified both nuclear and mitochondrial DNA (mtDNA) as well as superoxide production and the 4834 base pair 'common' mtDNA deletion. RESU", "tokenized_content": [2, 10738, 3, 17942, 4905, 2828, 2321, 4254, 1930, 4596, 2678, 12, 11183, 13, 1966, 2486, 1966, 10738, 3372, 1930, 1920, 29713, 1006, 5170, 3715, 11, 3059, 11, 11183, 5541, 18, 3]}, "items": [{"id": "p_232", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_233", "content": "glomerular and tubular lesions [SEP]  mtDNA deletion. RESULTS: The 'long-term' group had significant glomerular and tubular lesions, depressed activities of mtDNA-encoded NADH dehydrogenase and c", "tokenized_content": [2, 11655, 1930, 11755, 4518, 3, 11183, 5541, 18, 2274, 30, 1920, 11, 2815, 17, 2576, 11, 2210, 2430, 2228, 11655, 1930, 11755, 4518, 16, 11365, 4209, 1927, 11183, 17, 7905, 3]}, "items": [{"id": "p_233", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_234", "content": "citrate [SEP] NADH dehydrogenase and cytochrome-c oxidase (COX) and increased citrate synthase activity. In addition, expression of the mtDNA-encoded", "tokenized_content": [2, 11599, 3, 14261, 9294, 1930, 9387, 17, 45, 10488, 12, 6374, 13, 1930, 2502, 11599, 8921, 2455, 18, 1922, 2459, 16, 2294, 1927, 1920, 11183, 17, 7905, 3]}, "items": [{"id": "p_234", "content": "sodium citrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5227, 11599, 3, 3]}]}
{"query": {"id": "q_235", "content": "tubular lesions [SEP] ng nephropathy characterized by early glomerular and late-onset tubular lesions in rats. We investigated the potential role of mitochondrial in", "tokenized_content": [2, 11755, 4518, 3, 4375, 15582, 4378, 2007, 3120, 11655, 1930, 5058, 17, 4727, 11755, 4518, 1922, 3615, 18, 2038, 3845, 1920, 2889, 2770, 1927, 4596, 1922, 3]}, "items": [{"id": "p_235", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_236", "content": "glomerular lesions [SEP]  rats, there were fewer tubular lesions, but similar numbers of glomerular lesions activity. Among all animals, glomerular and tubular injury were", "tokenized_content": [2, 11655, 4518, 3, 3615, 16, 2276, 1985, 7380, 11755, 4518, 16, 2308, 2551, 4630, 1927, 11655, 4518, 2455, 18, 2706, 2136, 3555, 16, 11655, 1930, 11755, 4047, 1985, 3]}, "items": [{"id": "p_236", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_237", "content": "glomerular and tubular injury [SEP] ilar numbers of glomerular lesions activity. Among all animals, glomerular and tubular injury were inversely correlated with mtDNA levels, mtDNA-encoded resp", "tokenized_content": [2, 11655, 1930, 11755, 4047, 3, 2614, 1933, 4630, 1927, 11655, 4518, 2455, 18, 2706, 2136, 3555, 16, 11655, 1930, 11755, 4047, 1985, 12442, 4374, 1956, 11183, 2428, 16, 11183, 17, 3]}, "items": [{"id": "p_237", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_238", "content": "renal lesions [SEP] ain function and induction of superoxide in doxorubicin-induced renal lesions.", "tokenized_content": [2, 4604, 4518, 3, 9798, 1022, 2347, 1930, 4408, 1927, 10738, 1922, 12377, 17, 2719, 4604, 4518, 18, 3]}, "items": [{"id": "p_238", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_239", "content": "Amphotericin B [SEP] Amphotericin B-induced seizures in a patient with AIDS.", "tokenized_content": [2, 23210, 44, 3, 23210, 44, 17, 2719, 10060, 1922, 43, 2774, 1956, 8494, 18, 3]}, "items": [{"id": "p_239", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_240", "content": "seizures [SEP] Amphotericin B-induced seizures in a patient with AIDS.", "tokenized_content": [2, 10060, 3, 23210, 44, 17, 2719, 10060, 1922, 43, 2774, 1956, 8494, 18, 3]}, "items": [{"id": "p_240", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_241", "content": "AIDS [SEP] Amphotericin B-induced seizures in a patient with AIDS.", "tokenized_content": [2, 8494, 3, 23210, 44, 17, 2719, 10060, 1922, 43, 2774, 1956, 8494, 18, 3]}, "items": [{"id": "p_241", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_242", "content": "seizure [SEP] OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion. C", "tokenized_content": [2, 11015, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 3137, 9232, 1927, 11015, 2455, 1922, 1925, 8494, 16411, 2894, 23210, 44, 7386, 18, 45, 3]}, "items": [{"id": "p_242", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_243", "content": "AIDS [SEP] To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion. CASE SUMMARY: A 46-ye", "tokenized_content": [2, 8494, 3, 1942, 3809, 43, 3087, 1927, 3137, 9232, 1927, 11015, 2455, 1922, 1925, 8494, 16411, 2894, 23210, 44, 7386, 18, 3087, 6099, 30, 43, 4182, 17, 5293, 3]}, "items": [{"id": "p_243", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_244", "content": "amphotericin B [SEP] ltiple episodes of seizure activity in an AIDS patent following amphotericin B infusion. CASE SUMMARY: A 46-year-old African-American man expe", "tokenized_content": [2, 23210, 44, 3, 3457, 13229, 1021, 9232, 1927, 11015, 2455, 1922, 1925, 8494, 16411, 2894, 23210, 44, 7386, 18, 3087, 6099, 30, 43, 4182, 17, 2476, 17, 4156, 7050, 17, 3]}, "items": [{"id": "p_244", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_245", "content": "grand mal seizures [SEP] MMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal s", "tokenized_content": [2, 12038, 3054, 10060, 3, 29025, 6907, 30, 43, 4182, 17, 2476, 17, 4156, 7050, 17, 5339, 2323, 6090, 7457, 12038, 3054, 10060, 2409, 7307, 7386, 1927, 23210, 44, 16, 2759, 3]}, "items": [{"id": "p_245", "content": "Epilepsy, Tonic-Clonic [SEP] A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 16887, 17, 6138, 1935, 3, 43, 9612, 11015, 4770, 4378, 2007, 7457, 3044, 4842, 10060, 18, 1920, 3754, 5310, 16887, 3193, 1977, 4961, 2007, 13717, 3]}]}
{"query": {"id": "q_246", "content": "seizures [SEP] 6-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal s", "tokenized_content": [2, 10060, 3, 26, 17, 2476, 17, 4156, 7050, 17, 5339, 2323, 6090, 7457, 12038, 3054, 10060, 2409, 7307, 7386, 1927, 23210, 44, 16, 2759, 5889, 1932, 3054, 61, 3]}, "items": [{"id": "p_246", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_247", "content": "didanosine [SEP] creased with time. The patients concurrent medications included didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazin", "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 3478, 2148, 1956, 2367, 18, 1920, 2132, 10391, 7719, 3063, 2811, 9286, 6777, 1021, 16, 8275, 22030, 2912, 16, 2720, 3184, 10119, 16, 28184, 16, 3]}, "items": [{"id": "p_247", "content": "Didanosine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modificatio", "score": 1, "type": null, "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 43, 6201, 18, 2052, 2157, 2077, 1968, 1037, 3]}]}
{"query": {"id": "q_248", "content": "hydroxyzine [SEP]  time. The patients concurrent medications included didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazine. Despite ad", "tokenized_content": [2, 8275, 22030, 2912, 3, 2367, 18, 1920, 2132, 10391, 7719, 3063, 2811, 9286, 6777, 1021, 16, 8275, 22030, 2912, 16, 2720, 3184, 10119, 16, 28184, 16, 1930, 9823, 7806, 12157, 3]}, "items": [{"id": "p_248", "content": "Hydroxyzine [SEP] A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated p", "score": 1, "type": null, "tokenized_content": [2, 8275, 22030, 2912, 3, 43, 14622, 9169, 3148, 8151, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 3724, 27986, 6148, 16, 18006, 16, 1930, 14622, 17, 3434, 58, 3]}]}
{"query": {"id": "q_249", "content": "promethazine [SEP] tients concurrent medications included didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazine. Despite administration o", "tokenized_content": [2, 2720, 3184, 10119, 3, 19108, 4905, 1036, 10391, 7719, 3063, 2811, 9286, 6777, 1021, 16, 8275, 22030, 2912, 16, 2720, 3184, 10119, 16, 28184, 16, 1930, 9823, 7806, 12157, 7124, 3]}, "items": [{"id": "p_249", "content": "Promethazine [SEP] A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, i", "score": 1, "type": null, "tokenized_content": [2, 2720, 3184, 10119, 3, 43, 3037, 30354, 2053, 10533, 1956, 14622, 9169, 17, 7472, 16, 20330, 7801, 18979, 16, 1930, 28514, 3879, 18, 2176, 1977, 2251, 1966, 1925, 2246, 2214, 5237, 16, 51, 3]}]}
{"query": {"id": "q_250", "content": "hydrocortisone [SEP] ent medications included didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazine. Despite administration of phenytoin and ", "tokenized_content": [2, 28184, 3, 8496, 7719, 3063, 2811, 9286, 6777, 1021, 16, 8275, 22030, 2912, 16, 2720, 3184, 10119, 16, 28184, 16, 1930, 9823, 7806, 12157, 7124, 22030, 2912, 18, 4281, 4183, 3]}, "items": [{"id": "p_250", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_251", "content": "prochlorperazine [SEP] uded didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazine. Despite administration of phenytoin and lorazepam, the seizure", "tokenized_content": [2, 9823, 7806, 12157, 7124, 22030, 2912, 3, 19803, 1919, 2811, 9286, 6777, 1021, 16, 8275, 22030, 2912, 16, 2720, 3184, 10119, 16, 28184, 16, 1930, 9823, 7806, 12157, 7124, 22030, 3]}, "items": [{"id": "p_251", "content": "Prochlorperazine [SEP] A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPR", "score": 1, "type": null, "tokenized_content": [2, 9823, 7806, 12157, 7124, 22030, 2912, 3, 43, 3037, 30354, 2053, 17581, 2251, 22581, 1922, 1920, 2311, 1927, 13759, 31, 13954, 31, 1930, 3566, 28870, 18, 2176, 1977, 2253, 3205, 2254, 4891, 2047, 3]}]}
{"query": {"id": "q_252", "content": "phenytoin [SEP] hydrocortisone, and prochlorperazine. Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during ", "tokenized_content": [2, 3037, 30177, 3, 28184, 16, 1930, 9823, 7806, 12157, 7124, 22030, 2912, 18, 4281, 4183, 1927, 3037, 30177, 1930, 16394, 28231, 16, 1920, 10060, 14583, 1930, 4807, 2444, 2409, 3]}, "items": [{"id": "p_252", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_253", "content": "lorazepam [SEP] , and prochlorperazine. Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B ", "tokenized_content": [2, 16394, 28231, 3, 16, 1930, 9823, 7806, 12157, 7124, 22030, 2912, 18, 4281, 4183, 1927, 3037, 30177, 1930, 16394, 28231, 16, 1920, 10060, 14583, 1930, 4807, 2444, 2409, 22535, 3665, 3]}, "items": [{"id": "p_253", "content": "Lorazepam [SEP] A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sed", "score": 1, "type": null, "tokenized_content": [2, 16394, 28231, 3, 43, 27266, 2251, 1966, 1925, 2246, 17, 5592, 5899, 1956, 3855, 4159, 2564, 18, 2176, 2222, 2258, 25810, 3153, 16, 26572, 2031, 16, 1930, 7743, 6276, 3]}]}
{"query": {"id": "q_254", "content": "amphotercin B [SEP]  and lorazepam, the seizures persisted and occurred only during amphotercin B administration. DISCUSSION: AIDS and cryptococcal meningitis, b", "tokenized_content": [2, 22535, 3665, 44, 3, 1930, 16394, 28231, 16, 1920, 10060, 14583, 1930, 4807, 2444, 2409, 22535, 3665, 44, 4183, 18, 7248, 30, 8494, 1930, 11829, 11748, 16780, 16, 44, 3]}, "items": [{"id": "p_254", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_255", "content": "cryptococcal meningitis [SEP]  only during amphotercin B administration. DISCUSSION: AIDS and cryptococcal meningitis, both of which the patient had, can potentially cause seizures.", "tokenized_content": [2, 11829, 11748, 16780, 3, 2444, 2409, 22535, 3665, 44, 4183, 18, 7248, 30, 8494, 1930, 11829, 11748, 16780, 16, 2321, 1927, 2154, 1920, 2774, 2430, 16, 2112, 5063, 3936, 10060, 3]}, "items": [{"id": "p_255", "content": "Meningitis, Cryptococcal [SEP] Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED", "score": 1, "type": null, "tokenized_content": [2, 16780, 16, 11829, 11748, 3, 10286, 5243, 4531, 4152, 2007, 11829, 8256, 24276, 16, 1925, 15358, 5688, 1988, 15122, 1942, 15119, 3445, 1956, 5815, 3]}]}
{"query": {"id": "q_256", "content": "alcohol abuse [SEP] d, can potentially cause seizures. The patient had a history of alcohol abuse; alcohol intake as well as withdrawal can also cause seizures. ", "tokenized_content": [2, 4284, 7764, 3, 46, 16, 2112, 5063, 3936, 10060, 18, 1920, 2774, 2430, 43, 4403, 1927, 4284, 7764, 31, 4284, 5240, 1966, 2486, 1966, 9594, 2112, 2222, 3936, 10060, 18, 3]}, "items": [{"id": "p_256", "content": "Alcoholism [SEP] A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations.", "score": 1, "type": null, "tokenized_content": [2, 19866, 3, 43, 3065, 16, 3724, 2573, 1956, 3299, 16, 10718, 16, 1930, 4813, 2790, 11623, 2496, 2740, 1930, 10952, 18, 3]}]}
{"query": {"id": "q_257", "content": "alcohol [SEP] d, can potentially cause seizures. The patient had a history of alcohol abuse; alcohol intake as well as withdrawal can also cause seiz", "tokenized_content": [2, 4284, 3, 46, 16, 2112, 5063, 3936, 10060, 18, 1920, 2774, 2430, 43, 4403, 1927, 4284, 7764, 31, 4284, 5240, 1966, 2486, 1966, 9594, 2112, 2222, 3936, 7563, 3]}, "items": [{"id": "p_257", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_258", "content": "Didanosine [SEP] ; alcohol intake as well as withdrawal can also cause seizures. Didanosine also has a potential for inducing seizures. However, these othe", "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 31, 4284, 5240, 1966, 2486, 1966, 9594, 2112, 2222, 3936, 10060, 18, 2811, 9286, 6777, 1021, 2222, 2258, 43, 2889, 1958, 7834, 10060, 18, 2406, 3]}, "items": [{"id": "p_258", "content": "Didanosine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modificatio", "score": 1, "type": null, "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 43, 6201, 18, 2052, 2157, 2077, 1968, 1037, 3]}]}
{"query": {"id": "q_259", "content": "Amphotericin B [SEP] as the cause of the seizures in this AIDS patient. CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures. To date, only t", "tokenized_content": [2, 23210, 44, 3, 1966, 1920, 3936, 1927, 1920, 10060, 1922, 2052, 8494, 2774, 18, 4355, 30, 23210, 44, 6123, 1942, 1998, 1920, 12584, 3936, 1927, 1920, 10060, 18, 1942, 5699, 3]}, "items": [{"id": "p_259", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_260", "content": "tobramycin [SEP] Therapeutic drug monitoring of tobramycin: once-daily versus twice-daily dosage schedules.", "tokenized_content": [2, 7551, 29085, 4636, 3, 4272, 2838, 5378, 1927, 7551, 29085, 4636, 30, 5361, 17, 4692, 4072, 6470, 17, 4692, 9998, 19811, 18, 3]}, "items": [{"id": "p_260", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_261", "content": "tobramicyn [SEP] te the effect of dosage regimen (once-daily vs. twice-daily) of tobramicyn on steady-state serum concentrations and toxicity. MATERIALS AN", "tokenized_content": [2, 7551, 29085, 1935, 2304, 3, 3602, 1920, 2495, 1927, 9998, 8607, 12, 5361, 17, 4692, 3201, 18, 6470, 17, 4692, 13, 1927, 7551, 29085, 1935, 2304, 1990, 8121, 17, 3360, 3]}, "items": [{"id": "p_261", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_262", "content": "toxicity [SEP] e-daily) of tobramicyn on steady-state serum concentrations and toxicity. MATERIALS AND METHODS: Patients undergoing treatment with i.v.", "tokenized_content": [2, 5532, 3, 47, 17, 4692, 13, 1927, 7551, 29085, 1935, 2304, 1990, 8121, 17, 3360, 3256, 3295, 1930, 5532, 18, 4751, 1930, 2860, 30, 2132, 7258, 2311, 1956, 51, 18, 3]}, "items": [{"id": "p_262", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_263", "content": "tobramycin [SEP]  MATERIALS AND METHODS: Patients undergoing treatment with i.v. tobramycin (4 mg/kg/day) were randomised to two groups. Group OD (n = 22) ", "tokenized_content": [2, 7551, 29085, 4636, 3, 4751, 1930, 2860, 30, 2132, 7258, 2311, 1956, 51, 18, 64, 18, 7551, 29085, 4636, 12, 24, 2786, 19, 3621, 19, 3007, 13, 1985, 12090, 1942, 3]}, "items": [{"id": "p_263", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_264", "content": "Tobramycin [SEP] D (n = 21) received the same dose divided into two doses daily. Tobramycin serum concentrations (peak and trough) were measured by enzyme ", "tokenized_content": [2, 7551, 29085, 4636, 3, 46, 12, 56, 33, 2900, 13, 4004, 1920, 2841, 3253, 5831, 2460, 2288, 5312, 4692, 18, 7551, 29085, 4636, 3256, 3295, 12, 3833, 1930, 19737, 13, 3]}, "items": [{"id": "p_264", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_265", "content": "creatinine [SEP] /min/kg in OD vs. 1.28+/-0.33 ml/min/kg in TD). Increased serum creatinine was observed in 73% of patients in OD versus 57% of patients in", "tokenized_content": [2, 9374, 3, 19, 2360, 19, 3621, 1922, 4426, 3201, 18, 21, 18, 3158, 15, 19, 17, 20, 18, 3401, 2646, 19, 2360, 19, 3621, 1922, 6888, 13, 18, 2502, 3256, 3]}, "items": [{"id": "p_265", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_266", "content": "nephrotoxicity [SEP] atients in OD versus 57% of patients in TD, without evidence of nephrotoxicity. In TD group, three patients developed decreased auditory funct", "tokenized_content": [2, 27880, 3, 2019, 6746, 1922, 4426, 4072, 4786, 9, 1927, 2132, 1922, 6888, 16, 2979, 3095, 1927, 27880, 18, 1922, 6888, 2210, 16, 2559, 2132, 3530, 3261, 8401, 2277, 2341, 3]}, "items": [{"id": "p_266", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_267", "content": "decreased auditory function [SEP] idence of nephrotoxicity. In TD group, three patients developed decreased auditory function, of which one presented with an auditory loss of -30 dB, wherea", "tokenized_content": [2, 3261, 8401, 2347, 3, 6023, 1972, 1927, 27880, 18, 1922, 6888, 2210, 16, 2559, 2132, 3530, 3261, 8401, 2347, 16, 1927, 2154, 2340, 3549, 1956, 1925, 8401, 3257, 1927, 17, 3]}, "items": [{"id": "p_267", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_268", "content": "auditory loss [SEP] ped decreased auditory function, of which one presented with an auditory loss of -30 dB, whereas in the OD group only one patient presented d", "tokenized_content": [2, 8401, 3257, 3, 5296, 3261, 8401, 2347, 16, 1927, 2154, 2340, 3549, 1956, 1925, 8401, 3257, 1927, 17, 2627, 6594, 16, 3417, 1922, 1920, 4426, 2210, 2444, 2340, 2774, 3549, 3]}, "items": [{"id": "p_268", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_269", "content": "anthracycline [SEP] Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced ca", "tokenized_content": [2, 30021, 3, 3724, 2564, 1927, 43, 4008, 6830, 30021, 10533, 12, 2426, 17, 4804, 8851, 13, 1990, 2791, 4003, 1930, 12377, 17, 2719, 2332, 3]}, "items": [{"id": "p_269", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_270", "content": "SM-5887 [SEP] Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beag", "tokenized_content": [2, 2426, 17, 4804, 8851, 3, 3724, 2564, 1927, 43, 4008, 6830, 30021, 10533, 12, 2426, 17, 4804, 8851, 13, 1990, 2791, 4003, 1930, 12377, 17, 2719, 14141, 1922, 1998, 2006, 3]}, "items": [{"id": "p_270", "content": "amrubicin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24611, 11156, 3, 3]}]}
{"query": {"id": "q_271", "content": "doxorubicin [SEP] ynthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs.", "tokenized_content": [2, 12377, 3, 67, 4905, 4116, 2002, 30021, 10533, 12, 2426, 17, 4804, 8851, 13, 1990, 2791, 4003, 1930, 12377, 17, 2719, 14141, 1922, 1998, 15915, 1021, 7894, 18, 3]}, "items": [{"id": "p_271", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_272", "content": "cardiomyopathy [SEP] ne derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs.", "tokenized_content": [2, 14141, 3, 2069, 10533, 12, 2426, 17, 4804, 8851, 13, 1990, 2791, 4003, 1930, 12377, 17, 2719, 14141, 1922, 1998, 15915, 1021, 7894, 18, 3]}, "items": [{"id": "p_272", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_273", "content": "cardiotoxic [SEP] This study was designed to investigate the chronic cardiotoxic potential of SM-5887 and a possible deteriorating effect of SM-", "tokenized_content": [2, 21129, 4575, 18068, 1030, 3, 2052, 2161, 1982, 4609, 1942, 4482, 1920, 3724, 21129, 4575, 18068, 1030, 2889, 1927, 2426, 17, 4804, 8851, 1930, 43, 3216, 10901, 2287, 2495, 1927, 3]}, "items": [{"id": "p_273", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_274", "content": "SM-5887 [SEP] as designed to investigate the chronic cardiotoxic potential of SM-5887 and a possible deteriorating effect of SM-5887 on low-grade car", "tokenized_content": [2, 2426, 17, 4804, 8851, 3, 1966, 4609, 1942, 4482, 1920, 3724, 21129, 4575, 18068, 1030, 2889, 1927, 2426, 17, 4804, 8851, 1930, 43, 3216, 10901, 2287, 2495, 1927, 2426, 17, 3]}, "items": [{"id": "p_274", "content": "amrubicin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24611, 11156, 3, 3]}]}
{"query": {"id": "q_275", "content": "cardiotoxicity [SEP] 887 and a possible deteriorating effect of SM-5887 on low-grade cardiotoxicity pre-induced by doxorubicin in beagle dogs. In the chronic treat", "tokenized_content": [2, 30490, 3, 5744, 1027, 1930, 43, 3216, 10901, 2287, 2495, 1927, 2426, 17, 4804, 8851, 1990, 2330, 17, 4927, 30490, 2097, 17, 2719, 2007, 12377, 1922, 1998, 15915, 1021, 7894, 3]}, "items": [{"id": "p_275", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_276", "content": "doxorubicin [SEP] ng effect of SM-5887 on low-grade cardiotoxicity pre-induced by doxorubicin in beagle dogs. In the chronic treatment, beagle dogs of each s", "tokenized_content": [2, 12377, 3, 4375, 2495, 1927, 2426, 17, 4804, 8851, 1990, 2330, 17, 4927, 30490, 2097, 17, 2719, 2007, 12377, 1922, 1998, 15915, 1021, 7894, 18, 1922, 1920, 3724, 2311, 16, 3]}, "items": [{"id": "p_276", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_277", "content": "cardiomyopathy [SEP] es, decrease of blood pressure and high-grade histopathological cardiomyopathy, while animals which were terminally sacrificed after the SM-58", "tokenized_content": [2, 14141, 3, 2376, 16, 3714, 1927, 2877, 3772, 1930, 2149, 17, 4927, 11777, 14141, 16, 2679, 3555, 2154, 1985, 18328, 12891, 2256, 1920, 2426, 17, 4804, 3]}, "items": [{"id": "p_277", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_278", "content": "Parkinson's disease [SEP] Posteroventral medial pallidotomy in advanced Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 21270, 24439, 9588, 7922, 12574, 22389, 4575, 14930, 1922, 5570, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_278", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_279", "content": "Parkinson's disease [SEP] metimes produces striking improvement in patients with advanced Parkinson's disease, but the studies to date have involved small numbers of patient", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2130, 11593, 1036, 9300, 9784, 4990, 1922, 2132, 1956, 5570, 10124, 11, 61, 2573, 16, 2308, 1920, 2351, 1942, 5699, 2162, 3286, 2858, 4630, 1927, 3]}, "items": [{"id": "p_279", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_280", "content": "dyskinesias [SEP]  interval, 19 to 39 percent); on-period score for contralateral dyskinesias, 82 percent (95 percent confidence interval, 72 to 91 percent);", "tokenized_content": [2, 3890, 26682, 1036, 3, 4979, 16, 2282, 1942, 3886, 3564, 13, 31, 1990, 17, 3047, 3593, 1958, 10906, 3890, 26682, 1036, 16, 6175, 3564, 12, 3002, 3564, 5203, 4979, 16, 3]}, "items": [{"id": "p_280", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_281", "content": "parkinsonism [SEP] improvements in dyskinesias and the total scores for off-period parkinsonism, contralateral bradykinesia, and rigidity were sustained in the", "tokenized_content": [2, 26214, 3, 8137, 1922, 3890, 26682, 1036, 1930, 1920, 2698, 3888, 1958, 4013, 17, 3047, 26214, 16, 10906, 20152, 26682, 16, 1930, 20471, 1985, 7637, 1922, 1920, 3]}, "items": [{"id": "p_281", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_282", "content": "bradykinesia [SEP] and the total scores for off-period parkinsonism, contralateral bradykinesia, and rigidity were sustained in the 11 patients examined at two", "tokenized_content": [2, 20152, 26682, 3, 1930, 1920, 2698, 3888, 1958, 4013, 17, 3047, 26214, 16, 10906, 20152, 26682, 16, 1930, 20471, 1985, 7637, 1922, 1920, 2513, 2132, 3572, 2019, 2288, 3]}, "items": [{"id": "p_282", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_283", "content": "rigidity [SEP] es for off-period parkinsonism, contralateral bradykinesia, and rigidity were sustained in the 11 patients examined at two years. The im", "tokenized_content": [2, 20471, 3, 2376, 1958, 4013, 17, 3047, 26214, 16, 10906, 20152, 26682, 16, 1930, 20471, 1985, 7637, 1922, 1920, 2513, 2132, 3572, 2019, 2288, 2739, 18, 1920, 2042, 3]}, "items": [{"id": "p_283", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_284", "content": "levodopa [SEP] te-stage Parkinson's disease, pallidotomy significantly reduces levodopa-induced dyskinesias and off-period disability. Much of the bene", "tokenized_content": [2, 26723, 3, 3602, 17, 3587, 10124, 11, 61, 2573, 16, 12574, 22389, 4575, 14930, 2567, 7268, 26723, 17, 2719, 3890, 26682, 1036, 1930, 4013, 17, 3047, 8015, 18, 4186, 1927, 3]}, "items": [{"id": "p_284", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_285", "content": "pilocarpine [SEP] Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy.", "tokenized_content": [2, 7547, 7095, 12184, 3, 21908, 17, 67, 11522, 1922, 1920, 7547, 7095, 12184, 2322, 1927, 5338, 9581, 9741, 18, 3]}, "items": [{"id": "p_285", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_286", "content": "temporal lobe epilepsy [SEP] Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy.", "tokenized_content": [2, 5338, 9581, 9741, 3, 21908, 17, 67, 11522, 1922, 1920, 7547, 7095, 12184, 2322, 1927, 5338, 9581, 9741, 18, 3]}, "items": [{"id": "p_286", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_287", "content": "temporal lobe epilepsy [SEP] ssy fibres of the hippocampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mech", "tokenized_content": [2, 5338, 9581, 9741, 3, 4577, 1012, 15157, 1927, 1920, 7636, 17205, 10774, 2409, 3599, 5338, 9581, 9741, 12, 25356, 13, 18, 2052, 2294, 2278, 3015, 1925, 5355, 30135, 10685, 1023, 3]}, "items": [{"id": "p_287", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_288", "content": "TLE [SEP] ampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mechanism", "tokenized_content": [2, 25356, 3, 16983, 1024, 17205, 10774, 2409, 3599, 5338, 9581, 9741, 12, 25356, 13, 18, 2052, 2294, 2278, 3015, 1925, 5355, 30135, 2856, 3]}, "items": [{"id": "p_288", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_289", "content": "seizure [SEP]  endogenous damping mechanism since NPY has been shown to block seizure-like events following high-frequency stimulation in hippocampal", "tokenized_content": [2, 11015, 3, 5355, 30135, 2856, 3328, 18106, 2258, 2252, 2522, 1942, 3367, 11015, 17, 3189, 3916, 2894, 2149, 17, 3528, 4177, 1922, 7636, 3]}, "items": [{"id": "p_289", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_290", "content": "pilocarpine [SEP] following high-frequency stimulation in hippocampal slices. The pilocarpine (PILO) model of epilepsy is characterized by an acute period of", "tokenized_content": [2, 7547, 7095, 12184, 3, 2894, 2149, 17, 3528, 4177, 1922, 7636, 9002, 18, 1920, 7547, 7095, 12184, 12, 7547, 1037, 13, 2322, 1927, 9741, 1977, 4378, 2007, 1925, 3939, 3047, 3]}, "items": [{"id": "p_290", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_291", "content": "PILO [SEP] h-frequency stimulation in hippocampal slices. The pilocarpine (PILO) model of epilepsy is characterized by an acute period of statu", "tokenized_content": [2, 7547, 1037, 3, 50, 17, 3528, 4177, 1922, 7636, 9002, 18, 1920, 7547, 7095, 12184, 12, 7547, 1037, 13, 2322, 1927, 9741, 1977, 4378, 2007, 1925, 3939, 3047, 1927, 3156, 3]}, "items": [{"id": "p_291", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_292", "content": "epilepsy [SEP] the hippocampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mech", "tokenized_content": [2, 9741, 3, 1920, 7636, 17205, 10774, 2409, 3599, 5338, 9581, 9741, 12, 25356, 13, 18, 2052, 2294, 2278, 3015, 1925, 5355, 30135, 10685, 1023, 3]}, "items": [{"id": "p_292", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_293", "content": "status epilepticus [SEP] (PILO) model of epilepsy is characterized by an acute period of status epilepticus followed by spontaneous recurrent seizures and related brain da", "tokenized_content": [2, 3642, 16304, 1957, 3, 12, 7547, 1037, 13, 2322, 1927, 9741, 1977, 4378, 2007, 1925, 3939, 3047, 1927, 3642, 16304, 1957, 3489, 2007, 6242, 7457, 10060, 1930, 2712, 3068, 3692, 3]}, "items": [{"id": "p_293", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_294", "content": "seizures [SEP]  period of status epilepticus followed by spontaneous recurrent seizures and related brain damage. We report peroxidase-antiperoxidase i", "tokenized_content": [2, 10060, 3, 3047, 1927, 3642, 16304, 1957, 3489, 2007, 6242, 7457, 10060, 1930, 2712, 3068, 4293, 18, 2038, 3809, 9433, 17, 2246, 2116, 19883, 51, 3]}, "items": [{"id": "p_294", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_295", "content": "brain damage [SEP] lepticus followed by spontaneous recurrent seizures and related brain damage. We report peroxidase-antiperoxidase immunostaining for NPY in ", "tokenized_content": [2, 3068, 4293, 3, 16976, 24375, 3489, 2007, 6242, 7457, 10060, 1930, 2712, 3068, 4293, 18, 2038, 3809, 9433, 17, 2246, 2116, 19883, 10930, 1958, 18106, 1922, 3]}, "items": [{"id": "p_295", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_296", "content": "steroid [SEP] d as controls. During the follow-up, 3 patients (12%) developed steroid-induced elevated intraocular pressure (IOP) that resolved after", "tokenized_content": [2, 9507, 3, 46, 1966, 3562, 18, 2409, 1920, 2396, 17, 2353, 16, 23, 2132, 12, 2369, 9, 13, 3530, 9507, 17, 2719, 4664, 17258, 3772, 12, 12906, 13, 1988, 8397, 3]}, "items": [{"id": "p_296", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_297", "content": "elevated intraocular pressure [SEP] uring the follow-up, 3 patients (12%) developed steroid-induced elevated intraocular pressure (IOP) that resolved after corticosteroid therapy was discontinu", "tokenized_content": [2, 4664, 17258, 3772, 3, 3674, 1941, 1920, 2396, 17, 2353, 16, 23, 2132, 12, 2369, 9, 13, 3530, 9507, 17, 2719, 4664, 17258, 3772, 12, 12906, 13, 1988, 8397, 2256, 3]}, "items": [{"id": "p_297", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_298", "content": "corticosteroid [SEP] induced elevated intraocular pressure (IOP) that resolved after corticosteroid therapy was discontinued. RESULTS: No statistically significant", "tokenized_content": [2, 17980, 3, 2719, 4664, 17258, 3772, 12, 12906, 13, 1988, 8397, 2256, 17980, 3181, 1982, 16087, 18, 2274, 30, 2239, 4388, 2228, 3]}, "items": [{"id": "p_298", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_299", "content": "IOP rise [SEP]  to affect the posterior segment. The transient steroid-induced IOP rise did not seem to cause functional impairment.", "tokenized_content": [2, 12906, 7164, 3, 1942, 4081, 1920, 5545, 5367, 18, 1920, 6809, 9507, 17, 2719, 12906, 7164, 2811, 2084, 6521, 1942, 3936, 3183, 6159, 18, 3]}, "items": [{"id": "p_299", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_300", "content": "daunorubicin [SEP] Liposomal daunorubicin in advanced Kaposi's sarcoma: a phase II study.", "tokenized_content": [2, 3692, 1983, 11891, 3, 22768, 3692, 1983, 11891, 1922, 5570, 17367, 27545, 11, 61, 13970, 30, 43, 3193, 2890, 2161, 18, 3]}, "items": [{"id": "p_300", "content": "Daunorubicin [SEP] A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of L", "score": 1, "type": null, "tokenized_content": [2, 3692, 1983, 11891, 3, 43, 3345, 6161, 30021, 23029, 8028, 29128, 9969, 3937, 2037, 22874, 2737, 3005, 1914, 1957, 1930, 4991, 16, 2251, 1922, 2311, 1927, 54, 3]}]}
{"query": {"id": "q_301", "content": "Kaposi's sarcoma [SEP] Liposomal daunorubicin in advanced Kaposi's sarcoma: a phase II study.", "tokenized_content": [2, 17367, 27545, 11, 61, 13970, 3, 22768, 3692, 1983, 11891, 1922, 5570, 17367, 27545, 11, 61, 13970, 30, 43, 3193, 2890, 2161, 18, 3]}, "items": [{"id": "p_301", "content": "Sarcoma, Kaposi [SEP] A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, us", "score": 1, "type": null, "tokenized_content": [2, 13970, 16, 17367, 27545, 3, 43, 8844, 14635, 16, 6558, 12847, 4541, 4031, 4378, 2007, 1920, 2740, 1927, 2266, 15641, 17, 2312, 11276, 12128, 16, 2022, 3]}]}
{"query": {"id": "q_302", "content": "daunorubicin [SEP] I clinical trial to assess the efficacy and safety of liposomal daunorubicin (DaunoXome) in the treatment of AIDS related Kaposi's sarcoma. ", "tokenized_content": [2, 3692, 1983, 11891, 3, 51, 2535, 3046, 1942, 2634, 1920, 4348, 1930, 5407, 1927, 22768, 3692, 1983, 11891, 12, 3692, 1983, 2325, 2225, 13, 1922, 1920, 2311, 1927, 8494, 2712, 3]}, "items": [{"id": "p_302", "content": "Daunorubicin [SEP] A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of L", "score": 1, "type": null, "tokenized_content": [2, 3692, 1983, 11891, 3, 43, 3345, 6161, 30021, 23029, 8028, 29128, 9969, 3937, 2037, 22874, 2737, 3005, 1914, 1957, 1930, 4991, 16, 2251, 1922, 2311, 1927, 54, 3]}]}
{"query": {"id": "q_303", "content": "AIDS [SEP] afety of liposomal daunorubicin (DaunoXome) in the treatment of AIDS related Kaposi's sarcoma. Eleven homosexual men with advanced K", "tokenized_content": [2, 8494, 3, 2221, 3152, 1927, 22768, 3692, 1983, 11891, 12, 3692, 1983, 2325, 2225, 13, 1922, 1920, 2311, 1927, 8494, 2712, 17367, 27545, 11, 61, 13970, 18, 14483, 16350, 4127, 3]}, "items": [{"id": "p_303", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_304", "content": "Kaposi's sarcoma [SEP] somal daunorubicin (DaunoXome) in the treatment of AIDS related Kaposi's sarcoma. Eleven homosexual men with advanced Kaposi's sarcoma were ente", "tokenized_content": [2, 17367, 27545, 11, 61, 13970, 3, 18078, 1024, 3692, 1983, 11891, 12, 3692, 1983, 2325, 2225, 13, 1922, 1920, 2311, 1927, 8494, 2712, 17367, 27545, 11, 61, 13970, 18, 14483, 3]}, "items": [{"id": "p_304", "content": "Sarcoma, Kaposi [SEP] A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, us", "score": 1, "type": null, "tokenized_content": [2, 13970, 16, 17367, 27545, 3, 43, 8844, 14635, 16, 6558, 12847, 4541, 4031, 4378, 2007, 1920, 2740, 1927, 2266, 15641, 17, 2312, 11276, 12128, 16, 2022, 3]}]}
{"query": {"id": "q_305", "content": "oedema [SEP] re entered in the trial. Changes in size, colour and associated oedema of selected 'target' lesions were measured. Clinical, biochemic", "tokenized_content": [2, 24110, 3, 1964, 10725, 1922, 1920, 3046, 18, 2840, 1922, 3081, 16, 10917, 1930, 2458, 24110, 1927, 3790, 11, 2758, 11, 4518, 1985, 3045, 18, 2535, 16, 16161, 1935, 3]}, "items": [{"id": "p_305", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_306", "content": "toxicities [SEP] lesions were measured. Clinical, biochemical and haematological toxicities were assessed. Ten subjects were evaluated. A partial response ", "tokenized_content": [2, 15251, 3, 4518, 1985, 3045, 18, 2535, 16, 6503, 1930, 28691, 15251, 1985, 3683, 18, 5656, 3297, 1985, 3747, 18, 43, 5740, 2644, 3]}, "items": [{"id": "p_306", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_307", "content": "toxicity [SEP] he drug was generally well tolerated, with few mild symptoms of toxicity. The main problem encountered was haematological toxicity, with", "tokenized_content": [2, 5532, 3, 2234, 2838, 1982, 4933, 2486, 11117, 16, 1956, 3855, 5809, 3601, 1927, 5532, 18, 1920, 2730, 4915, 11989, 1982, 28691, 5532, 16, 1956, 3]}, "items": [{"id": "p_307", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_308", "content": "neutropenia [SEP] aematological toxicity, with three subjects experiencing severe neutropenia (neutrophil count < 0.5 x 10(9)/l). There was no evidence of ca", "tokenized_content": [2, 18005, 3, 10194, 3368, 4575, 22284, 2046, 5532, 16, 1956, 2559, 3297, 12511, 4010, 18005, 12, 9460, 6500, 32, 20, 18, 25, 66, 2119, 12, 29, 13, 19, 54, 13, 3]}, "items": [{"id": "p_308", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_309", "content": "cardiotoxicity [SEP] ia (neutrophil count < 0.5 x 10(9)/l). There was no evidence of cardiotoxicity. In this small patient sample, liposomal daunorubicin was an ef", "tokenized_content": [2, 30490, 3, 11640, 12, 9460, 6500, 32, 20, 18, 25, 66, 2119, 12, 29, 13, 19, 54, 13, 18, 2276, 1982, 2239, 3095, 1927, 30490, 18, 1922, 2052, 2858, 2774, 3]}, "items": [{"id": "p_309", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_310", "content": "heparin [SEP] Failure of ancrod in the treatment of heparin-induced arterial thrombosis.", "tokenized_content": [2, 9962, 3, 4574, 1927, 10315, 11483, 1922, 1920, 2311, 1927, 9962, 17, 2719, 6624, 11354, 18, 3]}, "items": [{"id": "p_310", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_311", "content": "thrombosis [SEP] Failure of ancrod in the treatment of heparin-induced arterial thrombosis.", "tokenized_content": [2, 11354, 3, 4574, 1927, 10315, 11483, 1922, 1920, 2311, 1927, 9962, 17, 2719, 6624, 11354, 18, 3]}, "items": [{"id": "p_311", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_312", "content": "heparin [SEP] The morbidity and mortality associated with heparin-induced thrombosis remain high despite numerous empirical thera", "tokenized_content": [2, 9962, 3, 1920, 7207, 1930, 3885, 2458, 1956, 9962, 17, 2719, 11354, 5555, 2149, 4281, 6466, 9203, 2704, 1019, 3]}, "items": [{"id": "p_312", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_313", "content": "thrombosis [SEP] The morbidity and mortality associated with heparin-induced thrombosis remain high despite numerous empirical therapies. Ancrod has be", "tokenized_content": [2, 11354, 3, 1920, 7207, 1930, 3885, 2458, 1956, 9962, 17, 2719, 11354, 5555, 2149, 4281, 6466, 9203, 6565, 18, 10315, 11483, 2258, 1998, 3]}, "items": [{"id": "p_313", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_314", "content": "platelet aggregation [SEP] inst development of thrombosis in patients with heparin induced platelet aggregation who require brief reexposure to heparin, but its success in pat", "tokenized_content": [2, 7163, 7883, 3, 4766, 2740, 1927, 11354, 1922, 2132, 1956, 9962, 2719, 7163, 7883, 2746, 4350, 5310, 30052, 2420, 2027, 1942, 9962, 16, 2308, 2496, 3811, 1922, 2917, 3]}, "items": [{"id": "p_314", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_315", "content": "Seizure [SEP] Seizure after flumazenil administration in a pediatric patient.", "tokenized_content": [2, 11015, 3, 11015, 2256, 2848, 3368, 7490, 1970, 4183, 1922, 43, 7460, 2774, 18, 3]}, "items": [{"id": "p_315", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_316", "content": "flumazenil [SEP] Seizure after flumazenil administration in a pediatric patient.", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 11015, 2256, 2848, 3368, 7490, 1970, 4183, 1922, 43, 7460, 2774, 18, 3]}, "items": [{"id": "p_316", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_317", "content": "Flumazenil [SEP] Flumazenil is a benzodiazepine receptor antagonist used to reverse sedatio", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 2848, 3368, 7490, 1970, 1977, 43, 27266, 3148, 8151, 2251, 1942, 5267, 6276, 1968, 1037, 3]}, "items": [{"id": "p_317", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_318", "content": "benzodiazepine [SEP] Flumazenil is a benzodiazepine receptor antagonist used to reverse sedation and respiratory de", "tokenized_content": [2, 27266, 3, 2848, 3368, 7490, 1970, 1977, 43, 27266, 3148, 8151, 2251, 1942, 5267, 15263, 1930, 5481, 2028, 3]}, "items": [{"id": "p_318", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_319", "content": "respiratory depression [SEP] benzodiazepine receptor antagonist used to reverse sedation and respiratory depression induced by benzodiazepines. Seizures and cardiac arrhythmias ha", "tokenized_content": [2, 5481, 4621, 3, 27266, 3148, 8151, 2251, 1942, 5267, 15263, 1930, 5481, 4621, 2719, 2007, 26555, 18, 10060, 1930, 4435, 16934, 2118, 3]}, "items": [{"id": "p_319", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_320", "content": "benzodiazepines [SEP]  used to reverse sedation and respiratory depression induced by benzodiazepines. Seizures and cardiac arrhythmias have complicated its use in a", "tokenized_content": [2, 26555, 3, 2251, 1942, 5267, 15263, 1930, 5481, 4621, 2719, 2007, 26555, 18, 10060, 1930, 4435, 16934, 2162, 9881, 2496, 2485, 1922, 43, 3]}, "items": [{"id": "p_320", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_321", "content": "Seizures [SEP] sedation and respiratory depression induced by benzodiazepines. Seizures and cardiac arrhythmias have complicated its use in adult patie", "tokenized_content": [2, 10060, 3, 15263, 1930, 5481, 4621, 2719, 2007, 26555, 18, 10060, 1930, 4435, 16934, 2162, 9881, 2496, 2485, 1922, 4160, 2091, 1021, 3]}, "items": [{"id": "p_321", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_322", "content": "cardiac arrhythmias [SEP] respiratory depression induced by benzodiazepines. Seizures and cardiac arrhythmias have complicated its use in adult patients. Overdose patients w", "tokenized_content": [2, 4435, 16934, 3, 5481, 4621, 2719, 2007, 26555, 18, 10060, 1930, 4435, 16934, 2162, 9881, 2496, 2485, 1922, 4160, 2132, 18, 21090, 2132, 65, 3]}, "items": [{"id": "p_322", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_323", "content": "Overdose [SEP] cardiac arrhythmias have complicated its use in adult patients. Overdose patients who have coingested tricyclic antidepressants have a h", "tokenized_content": [2, 21090, 3, 4435, 16934, 2162, 9881, 2496, 2485, 1922, 4160, 2132, 18, 21090, 2132, 2746, 2162, 24073, 2029, 8198, 12258, 13153, 17722, 2162, 43, 50, 3]}, "items": [{"id": "p_323", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_324", "content": "flumazenil [SEP] ations. Little information exists concerning adverse effects of flumazenil in children. We report the occurrence of a generalized tonic-cl", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 2019, 2443, 18, 5082, 2988, 8655, 8679, 5246, 2564, 1927, 2848, 3368, 7490, 1970, 1922, 3069, 18, 2038, 3809, 1920, 6564, 1927, 43, 9612, 16887, 3]}, "items": [{"id": "p_324", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_325", "content": "tonic-clonic seizure [SEP] umazenil in children. We report the occurrence of a generalized tonic-clonic seizure in a pediatric patient following the administration of flumazen", "tokenized_content": [2, 16887, 17, 6138, 1935, 11015, 3, 8736, 27168, 1970, 1922, 3069, 18, 2038, 3809, 1920, 6564, 1927, 43, 9612, 16887, 17, 6138, 1935, 11015, 1922, 43, 7460, 2774, 2894, 1920, 3]}, "items": [{"id": "p_325", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_326", "content": "isoniazid [SEP] Remodelling of nerve structure in experimental isoniazid neuropathy in the rat.", "tokenized_content": [2, 28383, 3, 19935, 1927, 5507, 3170, 1922, 3599, 28383, 13177, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_326", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_327", "content": "neuropathy [SEP] Remodelling of nerve structure in experimental isoniazid neuropathy in the rat.", "tokenized_content": [2, 13177, 3, 19935, 1927, 5507, 3170, 1922, 3599, 28383, 13177, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_327", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_328", "content": "neuropathy [SEP] The neuropathy caused by a single dose of isoniazid in rats was studied with a", "tokenized_content": [2, 13177, 3, 1920, 13177, 4189, 2007, 43, 2957, 3253, 1927, 28383, 1922, 3615, 1982, 3942, 1956, 43, 3]}, "items": [{"id": "p_328", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_329", "content": "isoniazid [SEP] The neuropathy caused by a single dose of isoniazid in rats was studied with a computer-assisted morphometric metho", "tokenized_content": [2, 28383, 3, 1920, 13177, 4189, 2007, 43, 2957, 3253, 1927, 28383, 1922, 3615, 1982, 3942, 1956, 43, 7058, 17, 9167, 21170, 2295, 1037, 3]}, "items": [{"id": "p_329", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_330", "content": "iopentol [SEP] Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the do", "tokenized_content": [2, 12906, 1939, 1945, 3, 5328, 4107, 1927, 12906, 1939, 1945, 16, 21509, 17797, 1945, 1930, 2130, 3027, 13642, 2010, 2460, 1920, 3506, 5846, 5511, 1927, 1920, 2608, 3]}, "items": [{"id": "p_330", "content": "iopentol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12906, 1939, 1945, 3, 3]}]}
{"query": {"id": "q_331", "content": "iohexol [SEP] Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induct", "tokenized_content": [2, 21509, 17797, 1945, 3, 5328, 4107, 1927, 12906, 1939, 1945, 16, 21509, 17797, 1945, 1930, 2130, 3027, 13642, 2010, 2460, 1920, 3506, 5846, 5511, 1927, 1920, 6567, 18, 4320, 1031, 3]}, "items": [{"id": "p_331", "content": "Iohexol [SEP] An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriograph", "score": 1, "type": null, "tokenized_content": [2, 21509, 17797, 1945, 3, 1925, 3655, 2447, 17, 11478, 16, 3224, 17, 6622, 3320, 5899, 2154, 1977, 2251, 1922, 5707, 3796, 16, 9273, 6405, 5524, 25818, 16, 7737, 1931, 9506, 3796, 16, 12480, 2893, 3]}]}
{"query": {"id": "q_332", "content": "metrizoate [SEP] Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induction of ventricu", "tokenized_content": [2, 2130, 3027, 13642, 2010, 3, 5328, 4107, 1927, 12906, 1939, 1945, 16, 21509, 17797, 1945, 1930, 2130, 3027, 13642, 2010, 2460, 1920, 3506, 5846, 5511, 1927, 1920, 6567, 18, 4408, 3]}, "items": [{"id": "p_332", "content": "Metrizoate [SEP] A diagnostic radiopaque that usually occurs as the sodium salt.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 3027, 13642, 2010, 3, 43, 4785, 8466, 4302, 5089, 1988, 5394, 5110, 1966, 1920, 5227, 7012, 18, 3]}]}
{"query": {"id": "q_333", "content": "ventricular fibrillation [SEP] trizoate into the left coronary artery of the dog. Induction of ventricular fibrillation and decrease of aortic pressure.", "tokenized_content": [2, 6493, 13671, 3, 15394, 25120, 2460, 1920, 3506, 5846, 5511, 1927, 1920, 6567, 18, 4408, 1927, 6493, 13671, 1930, 3714, 1927, 7677, 3772, 18, 3]}, "items": [{"id": "p_333", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_334", "content": "iopentol [SEP] lective injections were made into the left coronary artery with iopentol, iohexol and metrizoate in doses of 4 ml, 8 ml and 16 ml. Thirt", "tokenized_content": [2, 12906, 1939, 1945, 3, 17533, 2320, 8775, 1985, 3915, 2460, 1920, 3506, 5846, 5511, 1956, 12906, 1939, 1945, 16, 21509, 17797, 1945, 1930, 2130, 3027, 13642, 2010, 1922, 5312, 1927, 3]}, "items": [{"id": "p_334", "content": "iopentol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12906, 1939, 1945, 3, 3]}]}
{"query": {"id": "q_335", "content": "iohexol [SEP] jections were made into the left coronary artery with iopentol, iohexol and metrizoate in doses of 4 ml, 8 ml and 16 ml. Thirty-six iop", "tokenized_content": [2, 21509, 17797, 1945, 3, 8988, 2236, 1036, 1985, 3915, 2460, 1920, 3506, 5846, 5511, 1956, 12906, 1939, 1945, 16, 21509, 17797, 1945, 1930, 2130, 3027, 13642, 2010, 1922, 5312, 1927, 3]}, "items": [{"id": "p_335", "content": "Iohexol [SEP] An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriograph", "score": 1, "type": null, "tokenized_content": [2, 21509, 17797, 1945, 3, 1925, 3655, 2447, 17, 11478, 16, 3224, 17, 6622, 3320, 5899, 2154, 1977, 2251, 1922, 5707, 3796, 16, 9273, 6405, 5524, 25818, 16, 7737, 1931, 9506, 3796, 16, 12480, 2893, 3]}]}
{"query": {"id": "q_336", "content": "metrizoate [SEP] e made into the left coronary artery with iopentol, iohexol and metrizoate in doses of 4 ml, 8 ml and 16 ml. Thirty-six iopentol injection", "tokenized_content": [2, 2130, 3027, 13642, 2010, 3, 47, 3915, 2460, 1920, 3506, 5846, 5511, 1956, 12906, 1939, 1945, 16, 21509, 17797, 1945, 1930, 2130, 3027, 13642, 2010, 1922, 5312, 1927, 24, 2646, 3]}, "items": [{"id": "p_336", "content": "Metrizoate [SEP] A diagnostic radiopaque that usually occurs as the sodium salt.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 3027, 13642, 2010, 3, 43, 4785, 8466, 4302, 5089, 1988, 5394, 5110, 1966, 1920, 5227, 7012, 18, 3]}]}
{"query": {"id": "q_337", "content": "ventricular fibrillation [SEP] jections and 37 metrizoate injections were made. Frequencies of ventricular fibrillation were significantly lower (p less than 0.05) after iopentol (0%)", "tokenized_content": [2, 6493, 13671, 3, 8988, 2236, 1036, 1930, 3191, 2130, 3027, 13642, 2010, 8775, 1985, 3915, 18, 6458, 1927, 6493, 13671, 1985, 2567, 2826, 12, 58, 2941, 2254, 20, 18, 2914, 3]}, "items": [{"id": "p_337", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_338", "content": "Iopentol [SEP] ter iopentol (0%) and iohexol (3%) than after metrizoate (22%). Iopentol and iohexol also produced significantly less decrease in aortic", "tokenized_content": [2, 12906, 1939, 1945, 3, 6005, 12906, 1939, 1945, 12, 20, 9, 13, 1930, 21509, 17797, 1945, 12, 23, 9, 13, 2254, 2256, 2130, 3027, 13642, 2010, 12, 2950, 9, 13, 3]}, "items": [{"id": "p_338", "content": "iopentol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12906, 1939, 1945, 3, 3]}]}
{"query": {"id": "q_339", "content": "venous thrombosis [SEP] Magnetic resonance imaging of cerebral venous thrombosis secondary to \"low-dose\" birth control pills.", "tokenized_content": [2, 8562, 11354, 3, 5691, 6912, 3755, 1927, 6329, 8562, 11354, 4067, 1942, 6, 2330, 17, 3253, 6, 5043, 2285, 29099, 18, 3]}, "items": [{"id": "p_339", "content": "Venous Thrombosis [SEP] The formation or presence of a blood clot (THROMBUS) within a vein.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 11354, 3, 1920, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 2651, 43, 7920, 18, 3]}]}
{"query": {"id": "q_340", "content": "deep venous thrombosis [SEP] The clinical and radiographic features of cerebral deep venous thrombosis in a 21-year-old white woman are presented. This nulliparous pa", "tokenized_content": [2, 6515, 8562, 11354, 3, 1920, 2535, 1930, 12859, 4075, 1927, 6329, 6515, 8562, 11354, 1922, 43, 2900, 17, 2476, 17, 4156, 4511, 10440, 2032, 3549, 18, 2052, 6764, 25452, 3838, 3]}, "items": [{"id": "p_340", "content": "Venous Thrombosis [SEP] The formation or presence of a blood clot (THROMBUS) within a vein.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 11354, 3, 1920, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 2651, 43, 7920, 18, 3]}]}
{"query": {"id": "q_341", "content": "oral contraceptive [SEP] ental status changes. The only known risk factor was \"low-dose\" oral contraceptive pills. The magnetic resonance image (MRI) showed increased sign", "tokenized_content": [2, 4726, 16765, 3, 8496, 1923, 3642, 2840, 18, 1920, 2444, 3171, 2565, 2991, 1982, 6, 2330, 17, 3253, 6, 4726, 16765, 29099, 18, 1920, 5691, 6912, 4029, 12, 5371, 13, 3]}, "items": [{"id": "p_341", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_342", "content": "coronary stenosis [SEP] ed with myocardial contrast echocardiography to the severity of coronary stenosis: correlation with thallium-201 single-photon emission tomograph", "tokenized_content": [2, 5846, 10407, 3, 3347, 1956, 6497, 3320, 12814, 1942, 1920, 5155, 1927, 5846, 10407, 30, 3670, 1956, 15717, 12191, 1989, 17, 2262, 2957, 17, 11363, 7184, 5970, 2893, 3]}, "items": [{"id": "p_342", "content": "Coronary Stenosis [SEP] Narrowing or constriction of a coronary artery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10407, 3, 21005, 2014, 19837, 1927, 43, 5846, 5511, 18, 3]}]}
{"query": {"id": "q_343", "content": "thallium [SEP] iography to the severity of coronary stenosis: correlation with thallium-201 single-photon emission tomography.", "tokenized_content": [2, 15717, 12191, 1989, 3, 21509, 16677, 1942, 1920, 5155, 1927, 5846, 10407, 30, 3670, 1956, 15717, 12191, 1989, 17, 2262, 2957, 17, 11363, 7184, 7876, 18, 3]}, "items": [{"id": "p_343", "content": "Thallium [SEP] A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15717, 12191, 1989, 3, 43, 7881, 16, 2266, 15641, 4511, 6048, 16, 11241, 2529, 6206, 16, 11241, 3388, 37, 16368, 18, 27991, 31, 16368, 18, 25800, 39, 16, 17530, 10474, 18, 3]}]}
{"query": {"id": "q_344", "content": "coronary occlusion [SEP] r delineating regions of myocardial underperfusion secondary to coronary occlusion and to critical coronary stenoses in the presence of hyperemic ", "tokenized_content": [2, 5846, 10543, 3, 60, 11649, 2287, 3451, 1927, 6497, 18757, 1915, 9049, 4067, 1942, 5846, 10543, 1930, 1942, 4140, 5846, 9330, 12278, 1922, 1920, 2990, 1927, 24004, 4913, 3]}, "items": [{"id": "p_344", "content": "Coronary Occlusion [SEP] Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10543, 3, 4080, 23615, 1927, 2877, 3426, 2596, 2340, 1927, 1920, 5846, 9345, 16, 5394, 2037, 5846, 9824, 18, 3]}]}
{"query": {"id": "q_345", "content": "coronary stenoses [SEP]  underperfusion secondary to coronary occlusion and to critical coronary stenoses in the presence of hyperemic stimulation. The aim of this study", "tokenized_content": [2, 5846, 9330, 12278, 3, 18757, 1915, 9049, 4067, 1942, 5846, 10543, 1930, 1942, 4140, 5846, 9330, 12278, 1922, 1920, 2990, 1927, 24004, 4913, 4177, 18, 1920, 3774, 1927, 2052, 2161, 3]}, "items": [{"id": "p_345", "content": "Coronary Stenosis [SEP] Narrowing or constriction of a coronary artery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10407, 3, 21005, 2014, 19837, 1927, 43, 5846, 5511, 18, 3]}]}
{"query": {"id": "q_346", "content": "hyperemic [SEP]  occlusion and to critical coronary stenoses in the presence of hyperemic stimulation. The aim of this study was to determine whether myo", "tokenized_content": [2, 24004, 4913, 3, 10543, 1930, 1942, 4140, 5846, 9330, 12278, 1922, 1920, 2990, 1927, 24004, 4913, 4177, 18, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 3415, 3053, 15924, 3]}, "items": [{"id": "p_346", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_347", "content": "coronary stenosis [SEP]  of myocardial underperfusion resulting from various degrees of coronary stenosis. The perfusion defect produced in 16 open chest dogs was compar", "tokenized_content": [2, 5846, 10407, 3, 1927, 6497, 18757, 1915, 9049, 3864, 2037, 3425, 6429, 1927, 5846, 10407, 18, 1920, 8368, 7374, 4152, 1922, 2641, 4437, 8475, 7894, 1982, 2238, 3]}, "items": [{"id": "p_347", "content": "Coronary Stenosis [SEP] Narrowing or constriction of a coronary artery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10407, 3, 21005, 2014, 19837, 1927, 43, 5846, 5511, 18, 3]}]}
{"query": {"id": "q_348", "content": "thallium [SEP] sk measured by the postmortem dual-perfusion technique and with thallium-201 single-photon emission tomography (SPECT). During a transie", "tokenized_content": [2, 15717, 12191, 1989, 3, 3097, 3045, 2007, 1920, 19411, 7064, 17, 8368, 4778, 1930, 1956, 15717, 12191, 1989, 17, 2262, 2957, 17, 11363, 7184, 7876, 12, 4544, 13, 18, 2409, 3]}, "items": [{"id": "p_348", "content": "Thallium [SEP] A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15717, 12191, 1989, 3, 43, 7881, 16, 2266, 15641, 4511, 6048, 16, 11241, 2529, 6206, 16, 11241, 3388, 37, 16368, 18, 27991, 31, 16368, 18, 25800, 39, 16, 17530, 10474, 18, 3]}]}
{"query": {"id": "q_349", "content": "dipyridamole [SEP] the anatomic area at risk (r = 0.74; p less than 0.002). During dipyridamole-induced hyperemia, 12 of the 16 dogs with a partial coronary st", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 1920, 14145, 3403, 2019, 2565, 12, 60, 33, 20, 18, 5446, 31, 58, 2941, 2254, 20, 18, 9299, 13, 18, 2409, 9137, 3553, 9532, 3]}, "items": [{"id": "p_349", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_350", "content": "hyperemia [SEP] risk (r = 0.74; p less than 0.002). During dipyridamole-induced hyperemia, 12 of the 16 dogs with a partial coronary stenosis had a visib", "tokenized_content": [2, 24004, 6026, 3, 2565, 12, 60, 33, 20, 18, 5446, 31, 58, 2941, 2254, 20, 18, 9299, 13, 18, 2409, 9137, 3553, 9532, 12492, 1952, 17, 2719, 24004, 6026, 16, 3]}, "items": [{"id": "p_350", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_351", "content": "Thallium [SEP] nificantly with the anatomic area at risk (r = 0.61; p = 0.02). Thallium-201 SPECT demonstrated a perfusion defect in all 14 dogs analyz", "tokenized_content": [2, 15717, 12191, 1989, 3, 17719, 13611, 14598, 1012, 1956, 1920, 14145, 3403, 2019, 2565, 12, 60, 33, 20, 18, 5473, 31, 58, 33, 20, 18, 5725, 13, 18, 15717, 12191, 3]}, "items": [{"id": "p_351", "content": "Thallium [SEP] A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15717, 12191, 1989, 3, 43, 7881, 16, 2266, 15641, 4511, 6048, 16, 11241, 2529, 6206, 16, 11241, 3388, 37, 16368, 18, 27991, 31, 16368, 18, 25800, 39, 16, 17530, 10474, 18, 3]}]}
{"query": {"id": "q_352", "content": "furosemide [SEP] Potential deleterious effect of furosemide in radiocontrast nephropathy.", "tokenized_content": [2, 30509, 3, 2889, 12524, 2495, 1927, 30509, 1922, 8466, 12334, 10261, 2156, 15582, 18, 3]}, "items": [{"id": "p_352", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_353", "content": "nephropathy [SEP] Potential deleterious effect of furosemide in radiocontrast nephropathy.", "tokenized_content": [2, 15582, 3, 2889, 12524, 2495, 1927, 30509, 1922, 8466, 12334, 10261, 2156, 15582, 18, 3]}, "items": [{"id": "p_353", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_354", "content": "furosemide [SEP] The purpose of the study was to determine the efficacy of furosemide in addition to intravenous fluids in the prevention of radiocon", "tokenized_content": [2, 30509, 3, 1920, 5120, 1927, 1920, 2161, 1982, 1942, 3415, 1920, 4348, 1927, 30509, 1922, 2459, 1942, 7307, 13315, 1922, 1920, 5455, 1927, 8466, 12334, 3]}, "items": [{"id": "p_354", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_355", "content": "nephropathy [SEP] dition to intravenous fluids in the prevention of radiocontrast nephropathy. 18 patients, referred to a radiocontrast study, considered at ", "tokenized_content": [2, 15582, 3, 2137, 1929, 1942, 7307, 13315, 1922, 1920, 5455, 1927, 8466, 12334, 10261, 2156, 15582, 18, 2654, 2132, 16, 6656, 1942, 43, 8466, 12334, 10261, 2156, 2161, 16, 3311, 3]}, "items": [{"id": "p_355", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_356", "content": "renal insufficiency [SEP]  radiocontrast study, considered at risk because of preexisting renal insufficiency, were enrolled in a prospective, randomized, controlled trial, ", "tokenized_content": [2, 4604, 14566, 3, 8466, 12334, 10261, 2156, 2161, 16, 3311, 2019, 2565, 2882, 1927, 21604, 4604, 14566, 16, 1985, 7316, 1922, 43, 6315, 16, 5542, 16, 4642, 3046, 16, 3]}, "items": [{"id": "p_356", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_357", "content": "Renal function significantly deteriorated [SEP]  and non-ionic contrast material, at an average dose of 245 ml. Renal function significantly deteriorated in the group pretreated with furosemide (p < 0.005 by ANOVA), w", "tokenized_content": [2, 4604, 2347, 2567, 28236, 3, 1930, 2447, 17, 11478, 3320, 3485, 16, 2019, 1925, 3361, 3253, 1927, 20020, 2646, 18, 4604, 2347, 2567, 28236, 1922, 1920, 2210, 12152, 1956, 30509, 3]}, "items": [{"id": "p_357", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_358", "content": "creatinine [SEP] ated with furosemide (p < 0.005 by ANOVA), with a rise in serum creatinine from 145 +/- 13 to 182 +/- 16 mumol/l at 24 h, while no change ", "tokenized_content": [2, 9374, 3, 30280, 1007, 1956, 30509, 12, 58, 32, 20, 18, 9163, 2007, 5865, 13, 16, 1956, 43, 7164, 1922, 3256, 9374, 2037, 11491, 15, 19, 17, 2590, 1942, 15820, 3]}, "items": [{"id": "p_358", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_359", "content": "Renal failure [SEP] red in the control group (from 141 +/- 6 to 142 +/- 7 mumol/l). Renal failure was associated with weight loss in the furosemide-treated group", "tokenized_content": [2, 4604, 4574, 3, 2312, 1922, 1920, 2285, 2210, 12, 2037, 13603, 15, 19, 17, 26, 1942, 13680, 15, 19, 17, 27, 27078, 19, 54, 13, 18, 4604, 4574, 1982, 2458, 3]}, "items": [{"id": "p_359", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_360", "content": "weight loss [SEP]  +/- 6 to 142 +/- 7 mumol/l). Renal failure was associated with weight loss in the furosemide-treated group. Furosemide may be deleterious ", "tokenized_content": [2, 3388, 3257, 3, 15, 19, 17, 26, 1942, 13680, 15, 19, 17, 27, 27078, 19, 54, 13, 18, 4604, 4574, 1982, 2458, 1956, 3388, 3257, 1922, 1920, 30509, 17, 2868, 3]}, "items": [{"id": "p_360", "content": "Weight Loss [SEP] Decrease in existing BODY WEIGHT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 3257, 3, 3714, 1922, 6124, 3362, 3388, 18, 3]}]}
{"query": {"id": "q_361", "content": "Furosemide [SEP] as associated with weight loss in the furosemide-treated group. Furosemide may be deleterious in the prevention of radiocontrast nephropat", "tokenized_content": [2, 30509, 3, 1966, 2458, 1956, 3388, 3257, 1922, 1920, 30509, 17, 2868, 2210, 18, 30509, 2278, 1998, 12524, 1922, 1920, 5455, 1927, 8466, 12334, 10261, 2156, 7737, 2928, 1926, 3]}, "items": [{"id": "p_361", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_362", "content": "lithium [SEP] The renal pathology in a case of lithium-induced diabetes insipidus.", "tokenized_content": [2, 14330, 3, 1920, 4604, 6819, 1922, 43, 3087, 1927, 14330, 17, 2719, 4032, 2346, 2049, 22291, 18, 3]}, "items": [{"id": "p_362", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_363", "content": "diabetes insipidus [SEP] The renal pathology in a case of lithium-induced diabetes insipidus.", "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 1920, 4604, 6819, 1922, 43, 3087, 1927, 14330, 17, 2719, 4032, 2346, 2049, 22291, 18, 3]}, "items": [{"id": "p_363", "content": "Diabetes Insipidus [SEP] A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiolog", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 2573, 1988, 1977, 4378, 2007, 6439, 3674, 2636, 16, 11093, 1927, 3103, 6222, 1927, 24268, 6960, 16, 1930, 9122, 4053, 2156, 18, 8096, 2167, 3]}]}
{"query": {"id": "q_364", "content": "lithium [SEP] A case of lithium-induced diabetes insipidus is reported. At necropsy microscopy ", "tokenized_content": [2, 14330, 3, 43, 3087, 1927, 14330, 17, 2719, 4032, 2346, 2049, 22291, 1977, 2568, 18, 2019, 29135, 5441, 3]}, "items": [{"id": "p_364", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_365", "content": "diabetes insipidus [SEP] A case of lithium-induced diabetes insipidus is reported. At necropsy microscopy shoed unique and extensive ", "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 3087, 1927, 14330, 17, 2719, 4032, 2346, 2049, 22291, 1977, 2568, 18, 2019, 29135, 5441, 8406, 1919, 5008, 1930, 6475, 3]}, "items": [{"id": "p_365", "content": "Diabetes Insipidus [SEP] A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiolog", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 2573, 1988, 1977, 4378, 2007, 6439, 3674, 2636, 16, 11093, 1927, 3103, 6222, 1927, 24268, 6960, 16, 1930, 9122, 4053, 2156, 18, 8096, 2167, 3]}]}
{"query": {"id": "q_366", "content": "liver tumors [SEP] Etiologic factors in the pathogenesis of liver tumors associated with oral contraceptives.", "tokenized_content": [2, 3568, 3861, 3, 27633, 2790, 1922, 1920, 6559, 1927, 3568, 3861, 2458, 1956, 4726, 25434, 18, 3]}, "items": [{"id": "p_366", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_367", "content": "oral contraceptives [SEP] gic factors in the pathogenesis of liver tumors associated with oral contraceptives.", "tokenized_content": [2, 4726, 25434, 3, 7217, 1030, 2790, 1922, 1920, 6559, 1927, 3568, 3861, 2458, 1956, 4726, 25434, 18, 3]}, "items": [{"id": "p_367", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_368", "content": "liver tumors [SEP] Within the last several years, previously rare liver tumors have been seen in young women using oral contraceptive steroids", "tokenized_content": [2, 3568, 3861, 3, 2651, 1920, 4691, 2980, 2739, 16, 3024, 5844, 3568, 3861, 2162, 2252, 3945, 1922, 4201, 3089, 2193, 4726, 16765, 13039, 3]}, "items": [{"id": "p_368", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_369", "content": "oral contraceptive [SEP] reviously rare liver tumors have been seen in young women using oral contraceptive steroids. The Registry for Liver Tumors Associated with Oral Co", "tokenized_content": [2, 4726, 16765, 3, 5197, 27172, 5844, 3568, 3861, 2162, 2252, 3945, 1922, 4201, 3089, 2193, 4726, 16765, 13039, 18, 1920, 10557, 1958, 3568, 3861, 2458, 1956, 4726, 2081, 3]}, "items": [{"id": "p_369", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_370", "content": "steroids [SEP] r tumors have been seen in young women using oral contraceptive steroids. The Registry for Liver Tumors Associated with Oral Contracepti", "tokenized_content": [2, 13039, 3, 60, 3861, 2162, 2252, 3945, 1922, 4201, 3089, 2193, 4726, 16765, 13039, 18, 1920, 10557, 1958, 3568, 3861, 2458, 1956, 4726, 25266, 1914, 3]}, "items": [{"id": "p_370", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_371", "content": "Liver Tumors [SEP] young women using oral contraceptive steroids. The Registry for Liver Tumors Associated with Oral Contraceptives at the University of Califo", "tokenized_content": [2, 3568, 3861, 3, 4201, 3089, 2193, 4726, 16765, 13039, 18, 1920, 10557, 1958, 3568, 3861, 2458, 1956, 4726, 25434, 2019, 1920, 3926, 1927, 9657, 1037, 3]}, "items": [{"id": "p_371", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_372", "content": "Oral Contraceptives [SEP] ceptive steroids. The Registry for Liver Tumors Associated with Oral Contraceptives at the University of California, Irvine, has clearly identified", "tokenized_content": [2, 4726, 25434, 3, 17008, 2185, 13039, 18, 1920, 10557, 1958, 3568, 3861, 2458, 1956, 4726, 25434, 2019, 1920, 3926, 1927, 10191, 16, 3166, 23551, 16, 2258, 5436, 2899, 3]}, "items": [{"id": "p_372", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_373", "content": "focal nodular hyperplasia [SEP] ommon to these 71 cases has been a histopathologic diagnosis of focal nodular hyperplasia, adenoma, hamartoma, and hepatoma. Significant statistical etio", "tokenized_content": [2, 8083, 21106, 13095, 3, 7254, 3947, 1942, 2144, 5858, 2919, 2258, 2252, 43, 20324, 3574, 1927, 8083, 21106, 13095, 16, 16530, 16, 8616, 5263, 2954, 16, 1930, 23980, 18, 2228, 3]}, "items": [{"id": "p_373", "content": "Focal Nodular Hyperplasia [SEP] Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encaps", "score": 1, "type": null, "tokenized_content": [2, 8083, 21106, 13095, 3, 18992, 2014, 3137, 8867, 6095, 4541, 3861, 16, 5394, 6966, 1922, 3089, 1927, 2036, 17, 2761, 2739, 1927, 2632, 18, 1920, 17149, 16, 7865, 10771, 3]}]}
{"query": {"id": "q_374", "content": "adenoma [SEP]  been a histopathologic diagnosis of focal nodular hyperplasia, adenoma, hamartoma, and hepatoma. Significant statistical etiologic fac", "tokenized_content": [2, 16530, 3, 2252, 43, 20324, 3574, 1927, 8083, 21106, 13095, 16, 16530, 16, 8616, 5263, 2954, 16, 1930, 23980, 18, 2228, 3850, 27633, 3186, 3]}, "items": [{"id": "p_374", "content": "Adenoma [SEP] A benign epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16530, 3, 43, 8867, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_375", "content": "hamartoma [SEP] istopathologic diagnosis of focal nodular hyperplasia, adenoma, hamartoma, and hepatoma. Significant statistical etiologic factors includ", "tokenized_content": [2, 8616, 5263, 2954, 3, 1977, 27747, 2183, 4467, 3574, 1927, 8083, 21106, 13095, 16, 16530, 16, 8616, 5263, 2954, 16, 1930, 23980, 18, 2228, 3850, 27633, 2790, 2327, 3]}, "items": [{"id": "p_375", "content": "Hamartoma [SEP] A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the aff", "score": 1, "type": null, "tokenized_content": [2, 8616, 5263, 2954, 3, 43, 8083, 22138, 18994, 43, 12132, 16, 7179, 1927, 1925, 27342, 1927, 6665, 2094, 1930, 3878, 1988, 7885, 4704, 1922, 1920, 2633, 3]}]}
{"query": {"id": "q_376", "content": "hepatoma [SEP] diagnosis of focal nodular hyperplasia, adenoma, hamartoma, and hepatoma. Significant statistical etiologic factors include prolonged un", "tokenized_content": [2, 23980, 3, 3574, 1927, 8083, 21106, 13095, 16, 16530, 16, 8616, 5263, 2954, 16, 1930, 23980, 18, 2228, 3850, 27633, 2790, 3951, 7171, 2067, 3]}, "items": [{"id": "p_376", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_377", "content": "rupture [SEP] ed usage of oral contraceptive steroids. Eight deaths and liver rupture in 18 patients attest to the seriousness of this new potentiall", "tokenized_content": [2, 12460, 3, 3347, 10070, 1927, 4726, 16765, 13039, 18, 5066, 7601, 1930, 3568, 12460, 1922, 2654, 2132, 3099, 2158, 1942, 1920, 7433, 2971, 1927, 2052, 2814, 2889, 1024, 3]}, "items": [{"id": "p_377", "content": "Rupture [SEP] Forcible or traumatic tear or break of an organ or other soft part of the body.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12460, 3, 1958, 3349, 7272, 2014, 10242, 12650, 2014, 6017, 1927, 1925, 3090, 2014, 2303, 3793, 3131, 1927, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_378", "content": "Graft-versus-host disease [SEP] Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a", "tokenized_content": [2, 7668, 17, 4072, 17, 4423, 2573, 3, 7668, 17, 4072, 17, 4423, 2573, 12725, 1956, 24687, 1930, 21801, 1977, 2458, 1956, 43, 3]}, "items": [{"id": "p_378", "content": "Graft vs Host Disease [SEP] The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eve", "score": 1, "type": null, "tokenized_content": [2, 7668, 3201, 4423, 2573, 3, 1920, 2535, 14866, 4378, 2007, 21810, 16, 11904, 16, 3257, 1927, 7018, 16, 5104, 12903, 16, 17100, 16, 2905, 16342, 16, 1930, 2180, 1021, 3]}]}
{"query": {"id": "q_379", "content": "everolimus [SEP] Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoida", "tokenized_content": [2, 24687, 3, 7668, 17, 4072, 17, 4423, 2573, 12725, 1956, 24687, 1930, 21801, 1977, 2458, 1956, 43, 2149, 4332, 1927, 9414, 2642, 1019, 3]}, "items": [{"id": "p_379", "content": "everolimus [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24687, 3, 3]}]}
{"query": {"id": "q_380", "content": "tacrolimus [SEP] Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction s", "tokenized_content": [2, 21801, 3, 7668, 17, 4072, 17, 4423, 2573, 12725, 1956, 24687, 1930, 21801, 1977, 2458, 1956, 43, 2149, 4332, 1927, 21603, 10849, 61, 3]}, "items": [{"id": "p_380", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_381", "content": "sinusoidal obstruction syndrome [SEP] verolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial.", "tokenized_content": [2, 21603, 10849, 4741, 3, 19790, 7265, 1957, 1930, 21801, 1977, 2458, 1956, 43, 2149, 4332, 1927, 21603, 10849, 4741, 1930, 2703, 9506, 6522, 30, 2274, 1927, 1920, 2180, 3857, 1030, 3]}, "items": [{"id": "p_381", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_382", "content": "microangiopathy [SEP] ed with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial.", "tokenized_content": [2, 2703, 9506, 6522, 3, 3347, 1956, 43, 2149, 4332, 1927, 21603, 10849, 4741, 1930, 2703, 9506, 6522, 30, 2274, 1927, 1920, 2180, 3857, 1030, 3046, 18, 3]}, "items": [{"id": "p_382", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_383", "content": "methotrexate [SEP] A calcineurin inhibitor combined with methotrexate is the standard prophylaxis for graft-versus-host disease (GVHD", "tokenized_content": [2, 18031, 3, 43, 19555, 4106, 4252, 1956, 18031, 1977, 1920, 2970, 12725, 1958, 7668, 17, 4072, 17, 4423, 2573, 12, 16336, 3]}, "items": [{"id": "p_383", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_384", "content": "graft-versus-host disease [SEP] itor combined with methotrexate is the standard prophylaxis for graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation", "tokenized_content": [2, 7668, 17, 4072, 17, 4423, 2573, 3, 21384, 1005, 4252, 1956, 18031, 1977, 1920, 2970, 12725, 1958, 7668, 17, 4072, 17, 4423, 2573, 12, 16336, 13, 2256, 15224, 9960, 4402, 3]}, "items": [{"id": "p_384", "content": "Graft vs Host Disease [SEP] The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eve", "score": 1, "type": null, "tokenized_content": [2, 7668, 3201, 4423, 2573, 3, 1920, 2535, 14866, 4378, 2007, 21810, 16, 11904, 16, 3257, 1927, 7018, 16, 5104, 12903, 16, 17100, 16, 2905, 16342, 16, 1930, 2180, 1021, 3]}]}
{"query": {"id": "q_385", "content": "GVHD [SEP] xate is the standard prophylaxis for graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT", "tokenized_content": [2, 16336, 3, 23447, 2057, 1977, 1920, 2970, 12725, 1958, 7668, 17, 4072, 17, 4423, 2573, 12, 16336, 13, 2256, 15224, 9960, 4402, 2024, 6530, 12, 18299, 3]}, "items": [{"id": "p_385", "content": "Graft vs Host Disease [SEP] The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eve", "score": 1, "type": null, "tokenized_content": [2, 7668, 3201, 4423, 2573, 3, 1920, 2535, 14866, 4378, 2007, 21810, 16, 11904, 16, 3257, 1927, 7018, 16, 5104, 12903, 16, 17100, 16, 2905, 16342, 16, 1930, 2180, 1021, 3]}]}
{"query": {"id": "q_386", "content": "Everolimus [SEP] fter allogeneic hematopoietic stem cell transplantation (HSCT). Everolimus, a derivative of sirolimus, seems to mediate antileukemia effec", "tokenized_content": [2, 24687, 3, 8916, 1915, 15224, 9960, 4402, 2024, 6530, 12, 18299, 13, 18, 24687, 16, 43, 10533, 1927, 4520, 24124, 16, 6123, 1942, 8265, 2246, 8737, 3847, 2121, 1940, 3]}, "items": [{"id": "p_386", "content": "everolimus [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24687, 3, 3]}]}
{"query": {"id": "q_387", "content": "sirolimus [SEP] c stem cell transplantation (HSCT). Everolimus, a derivative of sirolimus, seems to mediate antileukemia effects. We report on a combinat", "tokenized_content": [2, 4520, 24124, 3, 45, 4402, 2024, 6530, 12, 18299, 13, 18, 24687, 16, 43, 10533, 1927, 4520, 24124, 16, 6123, 1942, 8265, 2246, 8737, 3847, 2564, 18, 2038, 3809, 1990, 3]}, "items": [{"id": "p_387", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_388", "content": "everolimus [SEP]  to mediate antileukemia effects. We report on a combination of everolimus and tacrolimus in 24 patients (median age, 62 years) with eithe", "tokenized_content": [2, 24687, 3, 1942, 8265, 2246, 8737, 3847, 2564, 18, 2038, 3809, 1990, 43, 3921, 1927, 24687, 1930, 21801, 1922, 2686, 2132, 12, 4181, 2632, 16, 5374, 2739, 13, 1956, 16101, 3]}, "items": [{"id": "p_388", "content": "everolimus [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24687, 3, 3]}]}
{"query": {"id": "q_389", "content": "tacrolimus [SEP] ileukemia effects. We report on a combination of everolimus and tacrolimus in 24 patients (median age, 62 years) with either myelodysplast", "tokenized_content": [2, 21801, 3, 9940, 3711, 3847, 2564, 18, 2038, 3809, 1990, 43, 3921, 1927, 24687, 1930, 21801, 1922, 2686, 2132, 12, 4181, 2632, 16, 5374, 2739, 13, 1956, 3108, 5707, 26812, 3]}, "items": [{"id": "p_389", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_390", "content": "myelodysplastic syndrome [SEP] nd tacrolimus in 24 patients (median age, 62 years) with either myelodysplastic syndrome (MDS; n = 17) or acute myeloid leukemia (AML; n = 7) undergoing", "tokenized_content": [2, 5707, 26812, 14170, 4741, 3, 8026, 21801, 1922, 2686, 2132, 12, 4181, 2632, 16, 5374, 2739, 13, 1956, 3108, 5707, 26812, 14170, 4741, 12, 10697, 31, 56, 33, 2752, 13, 3]}, "items": [{"id": "p_390", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_391", "content": "MDS [SEP] ts (median age, 62 years) with either myelodysplastic syndrome (MDS; n = 17) or acute myeloid leukemia (AML; n = 7) undergoing inte", "tokenized_content": [2, 10697, 3, 4894, 12, 4181, 2632, 16, 5374, 2739, 13, 1956, 3108, 5707, 26812, 14170, 4741, 12, 10697, 31, 56, 33, 2752, 13, 2014, 3939, 9677, 8111, 12, 9508, 31, 3]}, "items": [{"id": "p_391", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_392", "content": "acute myeloid leukemia [SEP] 62 years) with either myelodysplastic syndrome (MDS; n = 17) or acute myeloid leukemia (AML; n = 7) undergoing intensive conditioning followed by HSCT", "tokenized_content": [2, 3939, 9677, 8111, 3, 5374, 2739, 13, 1956, 3108, 5707, 26812, 14170, 4741, 12, 10697, 31, 56, 33, 2752, 13, 2014, 3939, 9677, 8111, 12, 9508, 31, 56, 33, 27, 3]}, "items": [{"id": "p_392", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_393", "content": "AML [SEP] elodysplastic syndrome (MDS; n = 17) or acute myeloid leukemia (AML; n = 7) undergoing intensive conditioning followed by HSCT from", "tokenized_content": [2, 9508, 3, 2349, 26812, 14170, 4741, 12, 10697, 31, 56, 33, 2752, 13, 2014, 3939, 9677, 8111, 12, 9508, 31, 56, 33, 27, 13, 7258, 8100, 10627, 3489, 2007, 18299, 3]}, "items": [{"id": "p_393", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_394", "content": "mucositis [SEP] All patients engrafted, and only 1 patient experienced grade IV mucositis. Nine patients (37%) developed acute grade II-IV GVHD, and 11 o", "tokenized_content": [2, 3422, 19976, 3, 2136, 2132, 18437, 1919, 16, 1930, 2444, 21, 2774, 6090, 4927, 4370, 3422, 19976, 18, 6360, 2132, 12, 3191, 9, 13, 3530, 3939, 4927, 2890, 17, 4370, 3]}, "items": [{"id": "p_394", "content": "Mucositis [SEP] An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vas", "score": 1, "type": null, "tokenized_content": [2, 3422, 19976, 3, 1925, 4531, 1927, 1920, 9680, 1956, 22873, 2014, 12347, 4365, 1941, 15826, 18, 2176, 1977, 4378, 2007, 10260, 1927, 1920, 10364, 8081, 16, 6350, 3]}]}
{"query": {"id": "q_395", "content": "Transplantation-associated microangiopathy [SEP] f 17 evaluable patients (64%) developed chronic extensive GVHD. Transplantation-associated microangiopathy (TMA) occurred in 7 patients (29%), with 2 cases of acute renal", "tokenized_content": [2, 6530, 17, 2458, 2703, 9506, 6522, 3, 48, 2752, 23626, 2132, 12, 4723, 9, 13, 3530, 3724, 6475, 16336, 18, 6530, 17, 2458, 2703, 9506, 6522, 12, 18391, 13, 4807, 3]}, "items": [{"id": "p_395", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_396", "content": "TMA [SEP] nic extensive GVHD. Transplantation-associated microangiopathy (TMA) occurred in 7 patients (29%), with 2 cases of acute renal fail", "tokenized_content": [2, 18391, 3, 11188, 6475, 16336, 18, 6530, 17, 2458, 2703, 9506, 6522, 12, 18391, 13, 4807, 1922, 27, 2132, 12, 3230, 9, 13, 16, 1956, 22, 2919, 1927, 3939, 4604, 3]}, "items": [{"id": "p_396", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_397", "content": "acute renal failure [SEP] oangiopathy (TMA) occurred in 7 patients (29%), with 2 cases of acute renal failure. The study was terminated prematurely because an additional 6 p", "tokenized_content": [2, 3939, 4604, 4574, 3, 8965, 2029, 22788, 15935, 12, 18391, 13, 4807, 1922, 27, 2132, 12, 3230, 9, 13, 16, 1956, 22, 2919, 1927, 3939, 4604, 4574, 18, 1920, 2161, 3]}, "items": [{"id": "p_397", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_398", "content": "sinusoidal obstruction syndrome [SEP] ed prematurely because an additional 6 patients (25%) developed sinusoidal obstruction syndrome (SOS), which was fatal in 2 cases. With a median follow-up of 2", "tokenized_content": [2, 21603, 10849, 4741, 3, 3347, 28283, 2882, 1925, 3281, 26, 2132, 12, 2637, 9, 13, 3530, 21603, 10849, 4741, 12, 17668, 13, 16, 2154, 1982, 11990, 1922, 22, 2919, 18, 3]}, "items": [{"id": "p_398", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_399", "content": "SOS [SEP] nal 6 patients (25%) developed sinusoidal obstruction syndrome (SOS), which was fatal in 2 cases. With a median follow-up of 26 mon", "tokenized_content": [2, 17668, 3, 13120, 26, 2132, 12, 2637, 9, 13, 3530, 21603, 10849, 4741, 12, 17668, 13, 16, 2154, 1982, 11990, 1922, 22, 2919, 18, 1956, 43, 4181, 2396, 17, 2353, 3]}, "items": [{"id": "p_399", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_400", "content": "loreclezole [SEP] Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-k", "tokenized_content": [2, 16394, 1940, 1952, 13642, 1952, 3, 2495, 1927, 2673, 4772, 6325, 2356, 1990, 1920, 6337, 2455, 1927, 16394, 1940, 1952, 13642, 1952, 1930, 2496, 7763, 1956, 23867, 2010, 2014, 6138, 3]}, "items": [{"id": "p_400", "content": "loreclezole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16394, 1940, 1952, 13642, 1952, 3, 3]}]}
{"query": {"id": "q_401", "content": "valproate [SEP] he protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats.", "tokenized_content": [2, 23867, 2010, 3, 2234, 6337, 2455, 1927, 16394, 1940, 1952, 13642, 1952, 1930, 2496, 7763, 1956, 23867, 2010, 2014, 6138, 28231, 1922, 10637, 17, 6925, 2824, 3615, 18, 3]}, "items": [{"id": "p_401", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_402", "content": "clonazepam [SEP]  activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats.", "tokenized_content": [2, 6138, 28231, 3, 2455, 1927, 16394, 1940, 1952, 13642, 1952, 1930, 2496, 7763, 1956, 23867, 2010, 2014, 6138, 28231, 1922, 10637, 17, 6925, 2824, 3615, 18, 3]}, "items": [{"id": "p_402", "content": "Clonazepam [SEP] An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absenc", "score": 1, "type": null, "tokenized_content": [2, 6138, 28231, 3, 1925, 26572, 2031, 2251, 1958, 2980, 3584, 1927, 10060, 16, 2710, 15924, 24970, 2014, 2019, 3490, 10060, 16, 27462, 1961, 9741, 16, 1930, 2872, 2135, 3]}]}
{"query": {"id": "q_403", "content": "Loreclezole [SEP] Loreclezole (5 mg/kg) exerted a significant protective action in amygdala-k", "tokenized_content": [2, 16394, 1940, 1952, 13642, 1952, 3, 16394, 1940, 1952, 13642, 1952, 12, 25, 2786, 19, 3621, 13, 14895, 43, 2228, 6337, 4615, 1922, 10637, 17, 53, 3]}, "items": [{"id": "p_403", "content": "loreclezole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16394, 1940, 1952, 13642, 1952, 3, 3]}]}
{"query": {"id": "q_404", "content": "seizure [SEP] icant protective action in amygdala-kindled rats, reducing both seizure and afterdischarge durations. The combinations of loreclezole (", "tokenized_content": [2, 11015, 3, 14784, 4905, 6337, 4615, 1922, 10637, 17, 6925, 2824, 3615, 16, 5526, 2321, 11015, 1930, 2256, 15783, 25588, 1005, 2106, 14998, 18, 1920, 7763, 1927, 16394, 1940, 1952, 3]}, "items": [{"id": "p_404", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_405", "content": "loreclezole [SEP]  both seizure and afterdischarge durations. The combinations of loreclezole (2.5 mg/kg) with valproate, clonazepam, or carbamazepine (appli", "tokenized_content": [2, 16394, 1940, 1952, 13642, 1952, 3, 2321, 11015, 1930, 2256, 15783, 25588, 1005, 2106, 14998, 18, 1920, 7763, 1927, 16394, 1940, 1952, 13642, 1952, 12, 22, 18, 25, 2786, 19, 3]}, "items": [{"id": "p_405", "content": "loreclezole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16394, 1940, 1952, 13642, 1952, 3, 3]}]}
{"query": {"id": "q_406", "content": "valproate [SEP] rge durations. The combinations of loreclezole (2.5 mg/kg) with valproate, clonazepam, or carbamazepine (applied at their subprotective d", "tokenized_content": [2, 23867, 2010, 3, 9372, 1021, 14998, 18, 1920, 7763, 1927, 16394, 1940, 1952, 13642, 1952, 12, 22, 18, 25, 2786, 19, 3621, 13, 1956, 23867, 2010, 16, 6138, 28231, 16, 3]}, "items": [{"id": "p_406", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_407", "content": "clonazepam [SEP] ns. The combinations of loreclezole (2.5 mg/kg) with valproate, clonazepam, or carbamazepine (applied at their subprotective doses) also e", "tokenized_content": [2, 6138, 28231, 3, 4246, 18, 1920, 7763, 1927, 16394, 1940, 1952, 13642, 1952, 12, 22, 18, 25, 2786, 19, 3621, 13, 1956, 23867, 2010, 16, 6138, 28231, 16, 2014, 30315, 3]}, "items": [{"id": "p_407", "content": "Clonazepam [SEP] An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absenc", "score": 1, "type": null, "tokenized_content": [2, 6138, 28231, 3, 1925, 26572, 2031, 2251, 1958, 2980, 3584, 1927, 10060, 16, 2710, 15924, 24970, 2014, 2019, 3490, 10060, 16, 27462, 1961, 9741, 16, 1930, 2872, 2135, 3]}]}
{"query": {"id": "q_408", "content": "carbamazepine [SEP] tions of loreclezole (2.5 mg/kg) with valproate, clonazepam, or carbamazepine (applied at their subprotective doses) also exhibited antiseizu", "tokenized_content": [2, 30315, 3, 8685, 2101, 1927, 16394, 1940, 1952, 13642, 1952, 12, 22, 18, 25, 2786, 19, 3621, 13, 1956, 23867, 2010, 16, 6138, 28231, 16, 2014, 30315, 12, 3730, 2019, 3]}, "items": [{"id": "p_408", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_409", "content": "bicuculline [SEP] o be of pharmacodynamic nature. Among several chemoconvulsants, bicuculline, N-methyl-D-aspartic acid and BAY k-8644 (the opener of L-type ", "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 57, 1998, 1927, 24358, 4899, 18, 2706, 2980, 13534, 12334, 1020, 6325, 2356, 16, 8876, 1978, 3199, 2053, 16, 56, 17, 4963, 17, 46, 17, 3]}, "items": [{"id": "p_409", "content": "Bicuculline [SEP] An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors", "score": 1, "type": null, "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 1925, 4911, 11072, 8419, 29951, 2926, 2037, 9192, 2334, 1019, 18242, 3199, 6148, 1930, 2303, 4793, 18, 2176, 1977, 43, 10362, 8151, 1958, 7992, 17, 43, 4086, 3]}]}
{"query": {"id": "q_410", "content": "N-methyl-D-aspartic acid [SEP] acodynamic nature. Among several chemoconvulsants, bicuculline, N-methyl-D-aspartic acid and BAY k-8644 (the opener of L-type calcium channels) reversed", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 23047, 2687, 3, 2000, 8325, 4899, 18, 2706, 2980, 13534, 12334, 1020, 6325, 2356, 16, 8876, 1978, 3199, 2053, 16, 56, 17, 4963, 17, 3]}, "items": [{"id": "p_410", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_411", "content": "BAY k-8644 [SEP] ral chemoconvulsants, bicuculline, N-methyl-D-aspartic acid and BAY k-8644 (the opener of L-type calcium channels) reversed the protective", "tokenized_content": [2, 7908, 53, 17, 5713, 6609, 3, 15906, 13534, 12334, 1020, 6325, 2356, 16, 8876, 1978, 3199, 2053, 16, 56, 17, 4963, 17, 46, 17, 23047, 2687, 1930, 7908, 53, 17, 3]}, "items": [{"id": "p_411", "content": "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester [SEP] A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 19604, 15339, 18276, 14523, 2687, 16, 21, 16, 24, 17, 11842, 17, 22, 16, 26, 17, 9780, 17, 25, 17, 8686, 17, 24, 17, 12, 22, 17, 12, 18560, 18403, 13, 7971, 13, 17, 16, 4963, 9603, 3, 43, 11842, 18425, 5802, 10533, 16, 2154, 16, 1922, 3320, 1942, 25968, 16, 4088, 1966, 43, 5016, 4999, 7829, 18, 1920, 3547, 11374, 3]}]}
{"query": {"id": "q_412", "content": "calcium [SEP] , N-methyl-D-aspartic acid and BAY k-8644 (the opener of L-type calcium channels) reversed the protective activity of loreclezole alone", "tokenized_content": [2, 5016, 3, 16, 56, 17, 4963, 17, 46, 17, 23047, 2687, 1930, 7908, 53, 17, 5713, 6609, 12, 1920, 4437, 1915, 1927, 54, 17, 2601, 5016, 5628, 13, 9432, 1920, 3]}, "items": [{"id": "p_412", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_413", "content": "aminophylline [SEP] its combination with valproate. On the other hand, bicuculline, aminophylline and BAY k-8644 inhibited the anticonvulsive action of loreclezo", "tokenized_content": [2, 3835, 25818, 11560, 2053, 3, 2496, 3921, 1956, 23867, 2010, 18, 1990, 1920, 2303, 3897, 16, 8876, 1978, 3199, 2053, 16, 3835, 25818, 11560, 2053, 1930, 7908, 53, 17, 5713, 3]}, "items": [{"id": "p_413", "content": "Aminophylline [SEP] A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar", "score": 1, "type": null, "tokenized_content": [2, 3835, 25818, 11560, 2053, 3, 43, 2838, 3921, 1988, 5461, 29629, 1930, 26436, 3812, 18, 2176, 1977, 2253, 6622, 1922, 3224, 2254, 29629, 2308, 2258, 2551, 3]}]}
{"query": {"id": "q_414", "content": "Acute liver failure [SEP] Acute liver failure with concurrent bupropion and carbimazole therapy.", "tokenized_content": [2, 3939, 3568, 4574, 3, 3939, 3568, 4574, 1956, 10391, 22955, 2928, 2001, 1930, 3697, 12874, 13642, 1952, 3181, 18, 3]}, "items": [{"id": "p_414", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_415", "content": "bupropion [SEP] Acute liver failure with concurrent bupropion and carbimazole therapy.", "tokenized_content": [2, 22955, 2928, 2001, 3, 3939, 3568, 4574, 1956, 10391, 22955, 2928, 2001, 1930, 3697, 12874, 13642, 1952, 3181, 18, 3]}, "items": [{"id": "p_415", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_416", "content": "carbimazole [SEP] Acute liver failure with concurrent bupropion and carbimazole therapy.", "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 3939, 3568, 4574, 1956, 10391, 22955, 2928, 2001, 1930, 3697, 12874, 13642, 1952, 3181, 18, 3]}, "items": [{"id": "p_416", "content": "Carbimazole [SEP] An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.\n  ", "score": 1, "type": null, "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 1925, 16045, 10310, 30338, 12245, 5899, 18, 3697, 12874, 13642, 1952, 1977, 19654, 1942, 2295, 12874, 13642, 1952, 16, 2154, 1977, 5061, 1958, 1920, 10310, 30338, 12245, 2455, 18, 3]}]}
{"query": {"id": "q_417", "content": "liver failure [SEP] OBJECTIVE: To report a case of fatal liver failure possibly associated with concurrent use of bupropion and carbim", "tokenized_content": [2, 3568, 4574, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 11990, 3568, 4574, 6553, 2458, 1956, 10391, 2485, 1927, 22955, 2928, 2001, 1930, 3697, 1980, 3]}, "items": [{"id": "p_417", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_418", "content": "bupropion [SEP]  fatal liver failure possibly associated with concurrent use of bupropion and carbimazole. CASE SUMMARY: A 41-year-old Chinese man with a", "tokenized_content": [2, 22955, 2928, 2001, 3, 11990, 3568, 4574, 6553, 2458, 1956, 10391, 2485, 1927, 22955, 2928, 2001, 1930, 3697, 12874, 13642, 1952, 18, 3087, 6099, 30, 43, 4353, 17, 2476, 17, 3]}, "items": [{"id": "p_418", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_419", "content": "carbimazole [SEP] ailure possibly associated with concurrent use of bupropion and carbimazole. CASE SUMMARY: A 41-year-old Chinese man with a history of hype", "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 30500, 2027, 6553, 2458, 1956, 10391, 2485, 1927, 22955, 2928, 2001, 1930, 3697, 12874, 13642, 1952, 18, 3087, 6099, 30, 43, 4353, 17, 2476, 17, 3]}, "items": [{"id": "p_419", "content": "Carbimazole [SEP] An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.\n  ", "score": 1, "type": null, "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 1925, 16045, 10310, 30338, 12245, 5899, 18, 3697, 12874, 13642, 1952, 1977, 19654, 1942, 2295, 12874, 13642, 1952, 16, 2154, 1977, 5061, 1958, 1920, 10310, 30338, 12245, 2455, 18, 3]}]}
{"query": {"id": "q_420", "content": "hyperthyroidism [SEP] zole. CASE SUMMARY: A 41-year-old Chinese man with a history of hyperthyroidism had been treated with carbimazole and propranolol for the past ", "tokenized_content": [2, 28413, 3, 21483, 1021, 18, 3087, 6099, 30, 43, 4353, 17, 2476, 17, 4156, 7185, 2323, 1956, 43, 4403, 1927, 28413, 2430, 2252, 2868, 1956, 3697, 12874, 13642, 1952, 1930, 3]}, "items": [{"id": "p_420", "content": "Hyperthyroidism [SEP] Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28413, 3, 10694, 1940, 10411, 2001, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 18, 4664, 2428, 1927, 6918, 10224, 2760, 5342, 4487, 2769, 18, 3]}]}
{"query": {"id": "q_421", "content": "propranolol [SEP] istory of hyperthyroidism had been treated with carbimazole and propranolol for the past 5 years. He received a 10-day course of bupropion ", "tokenized_content": [2, 21395, 3, 1977, 27708, 1927, 28413, 2430, 2252, 2868, 1956, 3697, 12874, 13642, 1952, 1930, 21395, 1958, 1920, 5375, 25, 2739, 18, 2234, 4004, 43, 2119, 17, 3007, 4914, 1927, 3]}, "items": [{"id": "p_421", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_422", "content": "acute liver failure [SEP]  smoking cessation 10 weeks prior to presentation. He developed acute liver failure with rapid deterioration of renal function. Liver biopsy showed", "tokenized_content": [2, 3939, 3568, 4574, 3, 5075, 10975, 2119, 3625, 3432, 1942, 6544, 18, 2234, 3530, 3939, 3568, 4574, 1956, 4052, 13318, 1927, 4604, 2347, 18, 3568, 6831, 2594, 3]}, "items": [{"id": "p_422", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_423", "content": "drug-induced acute liver injury [SEP]  of renal function. Liver biopsy showed evidence of nonspecific drug-induced acute liver injury. His condition was further complicated by sepsis and coagulopat", "tokenized_content": [2, 2838, 17, 2719, 3939, 3568, 4047, 3, 1927, 4604, 2347, 18, 3568, 6831, 2594, 3095, 1927, 12720, 2838, 17, 2719, 3939, 3568, 4047, 18, 4167, 2625, 1982, 2520, 9881, 2007, 3]}, "items": [{"id": "p_423", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_424", "content": "sepsis [SEP] ed acute liver injury. His condition was further complicated by sepsis and coagulopathy. Death resulted 19 days after the onset of sym", "tokenized_content": [2, 9019, 3, 3347, 3939, 3568, 4047, 18, 4167, 2625, 1982, 2520, 9881, 2007, 9019, 1930, 19804, 6522, 18, 3539, 4306, 2282, 3000, 2256, 1920, 4727, 1927, 2985, 3]}, "items": [{"id": "p_424", "content": "Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys", "score": 1, "type": null, "tokenized_content": [2, 9019, 3, 5510, 3769, 2644, 4741, 1956, 43, 9253, 2014, 9407, 7465, 10383, 18, 2469, 9019, 1977, 2458, 1956, 3090, 3890, 3]}]}
{"query": {"id": "q_425", "content": "coagulopathy [SEP] ver injury. His condition was further complicated by sepsis and coagulopathy. Death resulted 19 days after the onset of symptoms. The likeli", "tokenized_content": [2, 19804, 6522, 3, 3566, 4047, 18, 4167, 2625, 1982, 2520, 9881, 2007, 9019, 1930, 19804, 6522, 18, 3539, 4306, 2282, 3000, 2256, 1920, 4727, 1927, 3601, 18, 1920, 6759, 1033, 3]}, "items": [{"id": "p_425", "content": "Blood Coagulation Disorders [SEP] Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of facto", "score": 1, "type": null, "tokenized_content": [2, 2877, 12441, 4414, 3, 16052, 1930, 21039, 4414, 1988, 4704, 1966, 43, 7749, 1927, 6754, 1922, 2877, 12441, 2810, 1942, 43, 5386, 1927, 2371, 1037, 3]}]}
{"query": {"id": "q_426", "content": "hepatotoxicity [SEP] er the onset of symptoms. The likelihood that bupropion induced hepatotoxicity in our patient was possible, based on the Naranjo probability s", "tokenized_content": [2, 24126, 3, 2668, 1920, 4727, 1927, 3601, 18, 1920, 6772, 1988, 22955, 2928, 2001, 2719, 24126, 1922, 2342, 2774, 1982, 3216, 16, 2454, 1990, 1920, 7612, 1928, 15064, 5485, 61, 3]}, "items": [{"id": "p_426", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_427", "content": "acute liver insult [SEP] . CONCLUSIONS: Clinicians should be aware of the possibility of acute liver insult induced by bupropion given concurrently with other hepatotoxic ", "tokenized_content": [2, 3939, 3568, 20110, 3, 18, 4355, 30, 8575, 3066, 1998, 11207, 1927, 1920, 5341, 1927, 3939, 3568, 20110, 2719, 2007, 22955, 2928, 2001, 3258, 17194, 1956, 2303, 5746, 12899, 3]}, "items": [{"id": "p_427", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_428", "content": "hepatotoxic [SEP] er the onset of symptoms. The likelihood that bupropion induced hepatotoxicity in our patient was possible, based on the Naranjo probabilit", "tokenized_content": [2, 5746, 12899, 3, 2668, 1920, 4727, 1927, 3601, 18, 1920, 6772, 1988, 22955, 2928, 2001, 2719, 24126, 1922, 2342, 2774, 1982, 3216, 16, 2454, 1990, 1920, 7612, 1928, 15064, 17466, 3]}, "items": [{"id": "p_428", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_429", "content": "cardiovascular disease [SEP] oms and has also been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated v", "tokenized_content": [2, 5321, 2573, 3, 7254, 1036, 1930, 2258, 2222, 2252, 2251, 1958, 1920, 4280, 1930, 5455, 1927, 5321, 2573, 16, 12340, 1930, 7811, 1922, 4706, 3089, 18, 2052, 1977, 1925, 13236, 3]}, "items": [{"id": "p_429", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_430", "content": "osteoporosis [SEP] ed for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of the ", "tokenized_content": [2, 12340, 3, 3347, 1958, 1920, 4280, 1930, 5455, 1927, 5321, 2573, 16, 12340, 1930, 7811, 1922, 4706, 3089, 18, 2052, 1977, 1925, 13236, 4671, 1927, 1920, 3]}, "items": [{"id": "p_430", "content": "Osteoporosis [SEP] Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two m", "score": 1, "type": null, "tokenized_content": [2, 12340, 3, 3378, 1927, 3622, 3411, 2979, 10076, 1922, 1920, 5128, 1927, 3622, 16, 4523, 1942, 9018, 18, 3065, 12340, 2112, 1998, 1927, 2288, 55, 3]}]}
{"query": {"id": "q_431", "content": "dementia [SEP] ment and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of the original Coch", "tokenized_content": [2, 7811, 3, 11567, 1930, 5455, 1927, 5321, 2573, 16, 12340, 1930, 7811, 1922, 4706, 3089, 18, 2052, 1977, 1925, 13236, 4671, 1927, 1920, 5538, 8976, 3]}, "items": [{"id": "p_431", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_432", "content": "cancer [SEP] e effect of long-term HT on mortality, cardiovascular outcomes, cancer, gallbladder disease, cognition, fractures and quality of life.", "tokenized_content": [2, 2539, 3, 47, 2495, 1927, 2815, 17, 2576, 5334, 1990, 3885, 16, 5321, 3685, 16, 2539, 16, 19358, 2573, 16, 10032, 16, 9018, 1930, 3455, 1927, 3308, 18, 3]}, "items": [{"id": "p_432", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_433", "content": "gallbladder disease [SEP]  of long-term HT on mortality, cardiovascular outcomes, cancer, gallbladder disease, cognition, fractures and quality of life. SEARCH STRATEGY: We ", "tokenized_content": [2, 19358, 2573, 3, 1927, 2815, 17, 2576, 5334, 1990, 3885, 16, 5321, 3685, 16, 2539, 16, 19358, 2573, 16, 10032, 16, 9018, 1930, 3455, 1927, 3308, 18, 4603, 4884, 30, 3]}, "items": [{"id": "p_433", "content": "Gallbladder Diseases [SEP] Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, ne", "score": 1, "type": null, "tokenized_content": [2, 19358, 3902, 3, 3902, 1927, 1920, 19358, 18, 2611, 4933, 8156, 1920, 6159, 1927, 9619, 3426, 16, 9354, 22727, 1036, 1922, 1920, 13210, 6482, 16, 5024, 16, 2069, 3]}]}
{"query": {"id": "q_434", "content": "fractures [SEP] ardiovascular outcomes, cancer, gallbladder disease, cognition, fractures and quality of life. SEARCH STRATEGY: We searched the following", "tokenized_content": [2, 9018, 3, 2245, 7408, 4901, 3685, 16, 2539, 16, 19358, 2573, 16, 10032, 16, 9018, 1930, 3455, 1927, 3308, 18, 4603, 4884, 30, 2038, 11415, 1920, 2894, 3]}, "items": [{"id": "p_434", "content": "Fractures, Bone [SEP] Breaks in bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3622, 3, 13065, 1922, 14153, 18, 3]}]}
{"query": {"id": "q_435", "content": "Menstrual Disorders [SEP] ing databases to November 2007: Trials Register of the Cochrane Menstrual Disorders and Subfertility Group, Cochrane Central Register of Controlled", "tokenized_content": [2, 15994, 4414, 3, 30393, 8506, 1942, 12832, 3826, 30, 3848, 13801, 1927, 1920, 13917, 15994, 4414, 1930, 12967, 3062, 2275, 2210, 16, 13917, 4101, 13801, 1927, 4642, 3]}, "items": [{"id": "p_435", "content": "Menstruation Disturbances [SEP] Variations of menstruation which may be indicative of disease.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14333, 10874, 12654, 3, 6740, 1927, 14333, 10874, 2154, 2278, 1998, 10779, 1927, 2573, 18, 3]}]}
{"query": {"id": "q_436", "content": "oestrogens [SEP] one year by perimenopausal or postmenopausal women. HT included oestrogens, with or without progestogens, via oral, transdermal, subcutane", "tokenized_content": [2, 26266, 1036, 3, 2340, 2476, 2007, 2953, 19047, 10136, 2014, 14285, 3089, 18, 5334, 3063, 26266, 1036, 16, 1956, 2014, 2979, 10759, 4575, 7470, 16, 3454, 4726, 16, 29319, 16, 3]}, "items": [{"id": "p_436", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_437", "content": "progestogens [SEP] r postmenopausal women. HT included oestrogens, with or without progestogens, via oral, transdermal, subcutaneous or transnasal routes. DATA", "tokenized_content": [2, 10759, 4575, 7470, 3, 60, 14285, 3089, 18, 5334, 3063, 26266, 1036, 16, 1956, 2014, 2979, 10759, 4575, 7470, 16, 3454, 4726, 16, 29319, 16, 8634, 2014, 2127, 3676, 1923, 3]}, "items": [{"id": "p_437", "content": "Progesterone [SEP] The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTER", "score": 1, "type": null, "tokenized_content": [2, 11528, 3, 1920, 3044, 10759, 4926, 1923, 9507, 1988, 1977, 8366, 5985, 2007, 1920, 13776, 12867, 1989, 1930, 1920, 13752, 18, 11528, 8016, 1990, 1920, 8123, 3]}]}
{"query": {"id": "q_438", "content": "venous thrombo-embolism [SEP] men, combined continuous HT significantly increased the risk of venous thrombo-embolism or coronary event (after one year's use), stroke (after three y", "tokenized_content": [2, 8562, 16379, 17, 19287, 3, 3925, 16, 4252, 4798, 5334, 2567, 2502, 1920, 2565, 1927, 8562, 16379, 17, 19287, 2014, 5846, 4817, 12, 2256, 2340, 2476, 11, 61, 2485, 13, 3]}, "items": [{"id": "p_438", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_439", "content": "stroke [SEP] nous thrombo-embolism or coronary event (after one year's use), stroke (after three years), breast cancer and gallbladder disease. Lon", "tokenized_content": [2, 5235, 3, 2239, 1957, 16379, 17, 19287, 2014, 5846, 4817, 12, 2256, 2340, 2476, 11, 61, 2485, 13, 16, 5235, 12, 2256, 2559, 2739, 13, 16, 3739, 2539, 1930, 19358, 3]}, "items": [{"id": "p_439", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_440", "content": "breast cancer [SEP] onary event (after one year's use), stroke (after three years), breast cancer and gallbladder disease. Long-term oestrogen-only HT significan", "tokenized_content": [2, 3739, 2539, 3, 1990, 2141, 4817, 12, 2256, 2340, 2476, 11, 61, 2485, 13, 16, 5235, 12, 2256, 2559, 2739, 13, 16, 3739, 2539, 1930, 19358, 2573, 18, 2815, 17, 3]}, "items": [{"id": "p_440", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_441", "content": "oestrogen [SEP] one year by perimenopausal or postmenopausal women. HT included oestrogens, with or without progestogens, via oral, transdermal, subcutan", "tokenized_content": [2, 26266, 3, 2340, 2476, 2007, 2953, 19047, 10136, 2014, 14285, 3089, 18, 5334, 3063, 26266, 1036, 16, 1956, 2014, 2979, 10759, 4575, 7470, 16, 3454, 4726, 16, 29319, 16, 5736, 3]}, "items": [{"id": "p_441", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_442", "content": "colon cancer [SEP] T were a decreased incidence of fractures and (for combined HT) colon cancer, with long-term use. Among women aged over 65 who were relative", "tokenized_content": [2, 4120, 2539, 3, 62, 1985, 43, 3261, 4332, 1927, 9018, 1930, 12, 1958, 4252, 5334, 13, 4120, 2539, 16, 1956, 2815, 17, 2576, 2485, 18, 2706, 3089, 5177, 2338, 4459, 3]}, "items": [{"id": "p_442", "content": "Colonic Neoplasms [SEP] Tumors or cancer of the COLON.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12401, 15347, 3, 3861, 2014, 2539, 1927, 1920, 4120, 18, 3]}]}
{"query": {"id": "q_443", "content": "mannitol [SEP] Passage of mannitol into the brain around gliomas: a potential cause of rebound phe", "tokenized_content": [2, 20915, 3, 11008, 1927, 20915, 2460, 1920, 3068, 4760, 17083, 30, 43, 2889, 3936, 1927, 22845, 10422, 3]}, "items": [{"id": "p_443", "content": "Mannitol [SEP] A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from", "score": 1, "type": null, "tokenized_content": [2, 20915, 3, 43, 26829, 1930, 4604, 4785, 8379, 2712, 1942, 26297, 18, 2176, 2258, 5082, 2228, 3844, 3113, 1966, 2176, 1977, 6318, 11412, 2037, 3]}]}
{"query": {"id": "q_444", "content": "gliomas [SEP] Passage of mannitol into the brain around gliomas: a potential cause of rebound phenomenon. A study on 21 patient", "tokenized_content": [2, 17083, 3, 11008, 1927, 20915, 2460, 1920, 3068, 4760, 17083, 30, 43, 2889, 3936, 1927, 22845, 7902, 18, 43, 2161, 1990, 2900, 2774, 3]}, "items": [{"id": "p_444", "content": "Glioma [SEP] Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymo", "score": 1, "type": null, "tokenized_content": [2, 10683, 3, 8867, 1930, 6558, 4101, 7580, 2433, 15347, 3595, 2037, 10786, 2094, 12, 51, 18, 47, 18, 16, 8948, 16, 19279, 16, 1930, 27222, 1037, 3]}]}
{"query": {"id": "q_445", "content": "mannitol [SEP] AIM: Widespread use of mannitol to reduce brain edema and lower elevated ICP in brain tumor pat", "tokenized_content": [2, 20915, 3, 3774, 30, 9360, 2485, 1927, 20915, 1942, 4412, 3068, 10144, 1930, 2826, 4664, 13215, 1922, 3068, 2798, 2917, 3]}, "items": [{"id": "p_445", "content": "Mannitol [SEP] A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from", "score": 1, "type": null, "tokenized_content": [2, 20915, 3, 43, 26829, 1930, 4604, 4785, 8379, 2712, 1942, 26297, 18, 2176, 2258, 5082, 2228, 3844, 3113, 1966, 2176, 1977, 6318, 11412, 2037, 3]}]}
{"query": {"id": "q_446", "content": "brain edema [SEP] AIM: Widespread use of mannitol to reduce brain edema and lower elevated ICP in brain tumor patients continues to be ", "tokenized_content": [2, 3068, 10144, 3, 3774, 30, 9360, 2485, 1927, 20915, 1942, 4412, 3068, 10144, 1930, 2826, 4664, 13215, 1922, 3068, 2798, 2132, 12455, 1942, 1998, 3]}, "items": [{"id": "p_446", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_447", "content": "elevated ICP [SEP] AIM: Widespread use of mannitol to reduce brain edema and lower elevated ICP in brain tumor patients continues to be afflicted by the so-cal", "tokenized_content": [2, 4664, 13215, 3, 3774, 30, 9360, 2485, 1927, 20915, 1942, 4412, 3068, 10144, 1930, 2826, 4664, 13215, 1922, 3068, 2798, 2132, 12455, 1942, 1998, 2633, 3742, 2013, 2007, 1920, 2577, 3]}, "items": [{"id": "p_447", "content": "Intracranial Hypertension [SEP] Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intr", "score": 1, "type": null, "tokenized_content": [2, 12179, 5579, 3, 2502, 3772, 2651, 1920, 13598, 9315, 2402, 18, 2052, 2278, 3211, 2037, 2980, 2961, 16, 2710, 24408, 31, 3068, 10144, 31, 2738, 3]}]}
{"query": {"id": "q_448", "content": "brain tumor [SEP] use of mannitol to reduce brain edema and lower elevated ICP in brain tumor patients continues to be afflicted by the so-called rebound phe", "tokenized_content": [2, 3068, 2798, 3, 2485, 1927, 20915, 1942, 4412, 3068, 10144, 1930, 2826, 4664, 13215, 1922, 3068, 2798, 2132, 12455, 1942, 1998, 2633, 3742, 2013, 2007, 1920, 2577, 17, 6043, 22845, 3]}, "items": [{"id": "p_448", "content": "Brain Neoplasms [SEP] Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypot", "score": 1, "type": null, "tokenized_content": [2, 3068, 15347, 3, 15347, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 16, 2710, 1920, 6329, 21098, 16, 5342, 13086, 16, 12201, 3]}]}
{"query": {"id": "q_449", "content": "Mannitol [SEP] brain after administration to 21 brain tumor patients. METHODS: Mannitol (18% solution; 1 g/kg) was administered as a bolus to patients ", "tokenized_content": [2, 20915, 3, 3068, 2256, 4183, 1942, 2900, 3068, 2798, 2132, 18, 2860, 30, 20915, 12, 2654, 9, 3331, 31, 21, 49, 19, 3621, 13, 1982, 5254, 1966, 43, 14840, 1942, 3]}, "items": [{"id": "p_449", "content": "Mannitol [SEP] A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from", "score": 1, "type": null, "tokenized_content": [2, 20915, 3, 43, 26829, 1930, 4604, 4785, 8379, 2712, 1942, 26297, 18, 2176, 2258, 5082, 2228, 3844, 3113, 1966, 2176, 1977, 6318, 11412, 2037, 3]}]}
{"query": {"id": "q_450", "content": "malignant glioma [SEP] ution; 1 g/kg) was administered as a bolus to patients (ten had malignant glioma, seven brain metastases and four meningioma) about 30 minutes b", "tokenized_content": [2, 6558, 10683, 3, 21472, 1916, 31, 21, 49, 19, 3621, 13, 1982, 5254, 1966, 43, 14840, 1942, 2132, 12, 5656, 2430, 6558, 10683, 16, 5260, 3068, 8174, 1930, 3006, 30341, 3]}, "items": [{"id": "p_450", "content": "Glioma [SEP] Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymo", "score": 1, "type": null, "tokenized_content": [2, 10683, 3, 8867, 1930, 6558, 4101, 7580, 2433, 15347, 3595, 2037, 10786, 2094, 12, 51, 18, 47, 18, 16, 8948, 16, 19279, 16, 1930, 27222, 1037, 3]}]}
{"query": {"id": "q_451", "content": "metastases [SEP] d as a bolus to patients (ten had malignant glioma, seven brain metastases and four meningioma) about 30 minutes before craniotomy. During", "tokenized_content": [2, 8174, 3, 46, 1966, 43, 14840, 1942, 2132, 12, 5656, 2430, 6558, 10683, 16, 5260, 3068, 8174, 1930, 3006, 30341, 13, 3001, 2627, 4814, 3119, 21204, 4575, 14930, 18, 2409, 3]}, "items": [{"id": "p_451", "content": "Neoplasm Metastasis [SEP] The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12132, 5967, 3, 1920, 3856, 1927, 43, 12132, 2037, 2340, 3090, 2014, 3131, 1927, 1920, 3362, 1942, 3741, 12597, 2037, 1920, 3065, 3200, 18, 3]}]}
{"query": {"id": "q_452", "content": "meningioma [SEP] ents (ten had malignant glioma, seven brain metastases and four meningioma) about 30 minutes before craniotomy. During resection, a sample", "tokenized_content": [2, 30341, 3, 8496, 1036, 12, 5656, 2430, 6558, 10683, 16, 5260, 3068, 8174, 1930, 3006, 30341, 13, 3001, 2627, 4814, 3119, 21204, 4575, 14930, 18, 2409, 6953, 16, 43, 2983, 3]}, "items": [{"id": "p_452", "content": "Meningioma [SEP] A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentia", "score": 1, "type": null, "tokenized_content": [2, 30341, 3, 43, 4322, 3059, 12132, 1927, 1920, 4101, 7580, 2433, 1988, 14712, 2037, 15243, 20815, 1923, 2094, 18, 1920, 4827, 2032, 2486, 3269, 1019, 3]}]}
{"query": {"id": "q_453", "content": "edematous [SEP] efore craniotomy. During resection, a sample of the surrounding edematous white matter was taken at the same time as a 10 ml venous blood", "tokenized_content": [2, 10144, 4575, 1957, 3, 8485, 2073, 21204, 4575, 14930, 18, 2409, 6953, 16, 43, 2983, 1927, 1920, 7510, 10144, 4575, 1957, 4511, 6537, 1982, 4208, 2019, 1920, 2841, 2367, 1966, 3]}, "items": [{"id": "p_453", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_454", "content": "glioma [SEP] /kg) was administered as a bolus to patients (ten had malignant glioma, seven brain metastases and four meningioma) about 30 minutes b", "tokenized_content": [2, 10683, 3, 19, 3621, 13, 1982, 5254, 1966, 43, 14840, 1942, 2132, 12, 5656, 2430, 6558, 10683, 16, 5260, 3068, 8174, 1930, 3006, 30341, 13, 3001, 2627, 4814, 44, 3]}, "items": [{"id": "p_454", "content": "Glioma [SEP] Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymo", "score": 1, "type": null, "tokenized_content": [2, 10683, 3, 8867, 1930, 6558, 4101, 7580, 2433, 15347, 3595, 2037, 10786, 2094, 12, 51, 18, 47, 18, 16, 8948, 16, 19279, 16, 1930, 27222, 1037, 3]}]}
{"query": {"id": "q_455", "content": "gliomas [SEP]  a single bolus, mannitol may leak through the altered BBB near gliomas, reversing the initial plasma-to-blood osmotic gradient, aggrav", "tokenized_content": [2, 17083, 3, 43, 2957, 14840, 16, 20915, 2278, 9186, 2596, 1920, 5520, 12734, 4931, 17083, 16, 26526, 1920, 3754, 3582, 17, 1942, 17, 2877, 13951, 6494, 16, 18206, 3]}, "items": [{"id": "p_455", "content": "Glioma [SEP] Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymo", "score": 1, "type": null, "tokenized_content": [2, 10683, 3, 8867, 1930, 6558, 4101, 7580, 2433, 15347, 3595, 2037, 10786, 2094, 12, 51, 18, 47, 18, 16, 8948, 16, 19279, 16, 1930, 27222, 1037, 3]}]}
{"query": {"id": "q_456", "content": "edema [SEP] AIM: Widespread use of mannitol to reduce brain edema and lower elevated ICP in brain tumor patients continues to be ", "tokenized_content": [2, 10144, 3, 3774, 30, 9360, 2485, 1927, 20915, 1942, 4412, 3068, 10144, 1930, 2826, 4664, 13215, 1922, 3068, 2798, 2132, 12455, 1942, 1998, 3]}, "items": [{"id": "p_456", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_457", "content": "lidocaine [SEP] Can lidocaine reduce succinylcholine induced postoperative myalgia?", "tokenized_content": [2, 19567, 3, 2112, 19567, 4412, 13791, 2199, 11603, 2719, 5924, 3057, 20394, 2126, 35, 3]}, "items": [{"id": "p_457", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_458", "content": "succinylcholine [SEP] Can lidocaine reduce succinylcholine induced postoperative myalgia?", "tokenized_content": [2, 13791, 2199, 11603, 3, 2112, 19567, 4412, 13791, 2199, 11603, 2719, 5924, 3057, 20394, 2126, 35, 3]}, "items": [{"id": "p_458", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_459", "content": "postoperative myalgia [SEP] Can lidocaine reduce succinylcholine induced postoperative myalgia?", "tokenized_content": [2, 5924, 3057, 20394, 2126, 3, 2112, 19567, 4412, 13791, 2199, 11603, 2719, 5924, 3057, 20394, 2126, 35, 3]}, "items": [{"id": "p_459", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_460", "content": "lidocaine [SEP] This study was undertaken to determine the effect of lidocaine pretreatment on reduction of succinylcholine-induced myalgia in", "tokenized_content": [2, 19567, 3, 2052, 2161, 1982, 10466, 1942, 3415, 1920, 2495, 1927, 19567, 9111, 1990, 3378, 1927, 13791, 2199, 11603, 17, 2719, 3057, 20394, 2126, 1922, 3]}, "items": [{"id": "p_460", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_461", "content": "succinylcholine [SEP]  determine the effect of lidocaine pretreatment on reduction of succinylcholine-induced myalgia in patients undergoing general anesthesia for g", "tokenized_content": [2, 13791, 2199, 11603, 3, 3415, 1920, 2495, 1927, 19567, 9111, 1990, 3378, 1927, 13791, 2199, 11603, 17, 2719, 3057, 20394, 2126, 1922, 2132, 7258, 3335, 8871, 1958, 49, 3]}, "items": [{"id": "p_461", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_462", "content": "myalgia [SEP]  lidocaine pretreatment on reduction of succinylcholine-induced myalgia in patients undergoing general anesthesia for gynecological sur", "tokenized_content": [2, 3057, 20394, 2126, 3, 19567, 9111, 1990, 3378, 1927, 13791, 2199, 11603, 17, 2719, 3057, 20394, 2126, 1922, 2132, 7258, 3335, 8871, 1958, 30373, 2250, 3]}, "items": [{"id": "p_462", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_463", "content": "rocuronium [SEP] nd succinylcholine 1.5 mg x kg(-1); Group PR, normal saline and rocuronium 0.6 mg x kg(-1). Morphine 0.1 mg x kg(-1) iv was given for prem", "tokenized_content": [2, 10326, 10366, 2457, 3, 8026, 13791, 2199, 11603, 21, 18, 25, 2786, 66, 3621, 12, 17, 21, 13, 31, 2210, 2033, 16, 2791, 5977, 1930, 10326, 10366, 2457, 20, 18, 3]}, "items": [{"id": "p_463", "content": "rocuronium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10326, 10366, 2457, 3, 3]}]}
{"query": {"id": "q_464", "content": "Morphine [SEP] kg(-1); Group PR, normal saline and rocuronium 0.6 mg x kg(-1). Morphine 0.1 mg x kg(-1) iv was given for premedication and all patients", "tokenized_content": [2, 11553, 3, 3621, 12, 17, 21, 13, 31, 2210, 2033, 16, 2791, 5977, 1930, 10326, 10366, 2457, 20, 18, 26, 2786, 66, 3621, 12, 17, 21, 13, 18, 11553, 20, 3]}, "items": [{"id": "p_464", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_465", "content": "thiopental [SEP] ECG and pulse oximetry. Anesthesia was induced with 5 mg.kg(-1) thiopental iv. followed by succinylcholine (Group PS, LS) or rocuronium (G", "tokenized_content": [2, 15331, 17125, 2381, 3, 11497, 1930, 7110, 21988, 5414, 18, 8871, 1982, 2719, 1956, 25, 2786, 18, 3621, 12, 17, 21, 13, 15331, 17125, 2381, 4370, 18, 3489, 2007, 13791, 3]}, "items": [{"id": "p_465", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_466", "content": "fasciculation [SEP] ing administration of these agents, the presence, and degree of fasciculation were assessed visually on a four point scale by one investigato", "tokenized_content": [2, 29990, 18021, 6055, 3, 30393, 4183, 1927, 2144, 4820, 16, 1920, 2990, 16, 1930, 4647, 1927, 29990, 18021, 6055, 1985, 3683, 14152, 1990, 43, 3006, 3575, 3536, 2007, 2340, 2772, 3]}, "items": [{"id": "p_466", "content": "Fasciculation [SEP] Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the for", "score": 1, "type": null, "tokenized_content": [2, 29990, 18021, 6055, 3, 28493, 8332, 1927, 1920, 3760, 6989, 29882, 2007, 43, 4842, 5344, 18, 29990, 18021, 6055, 1036, 2112, 3868, 2007, 8559, 1930, 6132, 1920, 1958, 3]}]}
{"query": {"id": "q_467", "content": "muscle fasciculation [SEP] ded to the intraoperative management. The results indicate that muscle fasciculation was not found in Group PR while the patients in Group LS had a ", "tokenized_content": [2, 3760, 29990, 18021, 6055, 3, 11481, 1942, 1920, 12122, 4280, 18, 1920, 2274, 3579, 1988, 3760, 29990, 18021, 6055, 1982, 2084, 2435, 1922, 2210, 2033, 2679, 1920, 2132, 1922, 2210, 3]}, "items": [{"id": "p_467", "content": "Fasciculation [SEP] Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the for", "score": 1, "type": null, "tokenized_content": [2, 29990, 18021, 6055, 3, 28493, 8332, 1927, 1920, 3760, 6989, 29882, 2007, 43, 4842, 5344, 18, 29990, 18021, 6055, 1036, 2112, 3868, 2007, 8559, 1930, 6132, 1920, 1958, 3]}]}
{"query": {"id": "q_468", "content": "postoperative myalgia [SEP] proven to be the useful pretreatment agent for the reduction of postoperative myalgia.", "tokenized_content": [2, 5924, 3057, 20394, 2126, 3, 9253, 1942, 1998, 1920, 4707, 9111, 5899, 1958, 1920, 3378, 1927, 5924, 3057, 20394, 2126, 18, 3]}, "items": [{"id": "p_468", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_469", "content": "levofloxacin [SEP] Open-label assessment of levofloxacin for the treatment of acute bacterial sinusitis in adults.", "tokenized_content": [2, 30129, 14217, 3, 4437, 17, 3954, 4076, 1927, 30129, 14217, 1958, 1920, 2311, 1927, 3939, 4543, 9414, 3678, 1922, 4440, 18, 3]}, "items": [{"id": "p_469", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_470", "content": "sinusitis [SEP] assessment of levofloxacin for the treatment of acute bacterial sinusitis in adults.", "tokenized_content": [2, 9414, 3678, 3, 4076, 1927, 30129, 14217, 1958, 1920, 2311, 1927, 3939, 4543, 9414, 3678, 1922, 4440, 18, 3]}, "items": [{"id": "p_470", "content": "Sinusitis [SEP] Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9414, 3678, 3, 4531, 1927, 1920, 9305, 9680, 1922, 2340, 2014, 2253, 1927, 1920, 26124, 14046, 28436, 18, 3]}]}
{"query": {"id": "q_471", "content": "levofloxacin [SEP] PURPOSE: To evaluate the efficacy and safety of levofloxacin (500 mg orally once daily for 10 to 14 days) in treating adult ", "tokenized_content": [2, 30129, 14217, 3, 5120, 30, 1942, 4323, 1920, 4348, 1930, 5407, 1927, 30129, 14217, 12, 4599, 2786, 12950, 5361, 4692, 1958, 2119, 1942, 2607, 3000, 13, 1922, 8247, 4160, 3]}, "items": [{"id": "p_471", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_472", "content": "sinusitis [SEP]  to 14 days) in treating adult outpatients with acute bacterial sinusitis. PATIENTS AND METHODS: A total of 329 patients enrolled in the ", "tokenized_content": [2, 9414, 3678, 3, 1942, 2607, 3000, 13, 1922, 8247, 4160, 20204, 1956, 3939, 4543, 9414, 3678, 18, 2132, 1930, 2860, 30, 43, 2698, 1927, 25725, 2132, 7316, 1922, 1920, 3]}, "items": [{"id": "p_472", "content": "Sinusitis [SEP] Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9414, 3678, 3, 4531, 1927, 1920, 9305, 9680, 1922, 2340, 2014, 2253, 1927, 1920, 26124, 14046, 28436, 18, 3]}]}
{"query": {"id": "q_473", "content": "diarrhea [SEP] patients (9%). The most common drug-related adverse events were diarrhea, flatulence, and nausea; most adverse events were mild to moder", "tokenized_content": [2, 11904, 3, 2132, 12, 29, 9, 13, 18, 1920, 2501, 3059, 2838, 17, 2712, 5246, 3916, 1985, 11904, 16, 9778, 25916, 16, 1930, 13759, 31, 2501, 5246, 3916, 1985, 5809, 3]}, "items": [{"id": "p_473", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_474", "content": "flatulence [SEP] 9%). The most common drug-related adverse events were diarrhea, flatulence, and nausea; most adverse events were mild to moderate in sever", "tokenized_content": [2, 9778, 25916, 3, 29, 9, 13, 18, 1920, 2501, 3059, 2838, 17, 2712, 5246, 3916, 1985, 11904, 16, 9778, 25916, 16, 1930, 13759, 31, 2501, 5246, 3916, 1985, 5809, 1942, 3]}, "items": [{"id": "p_474", "content": "Flatulence [SEP] Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9778, 25916, 3, 3372, 2014, 2990, 1927, 4422, 1922, 1920, 8375, 6482, 2154, 2278, 1998, 2887, 7667, 2596, 1920, 1925, 1957, 18, 3]}]}
{"query": {"id": "q_475", "content": "nausea [SEP] mmon drug-related adverse events were diarrhea, flatulence, and nausea; most adverse events were mild to moderate in severity. CONCLUS", "tokenized_content": [2, 13759, 3, 2489, 1916, 2838, 17, 2712, 5246, 3916, 1985, 11904, 16, 9778, 25916, 16, 1930, 13759, 31, 2501, 5246, 3916, 1985, 5809, 1942, 5086, 1922, 5155, 18, 3008, 1957, 3]}, "items": [{"id": "p_475", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_476", "content": "prostacyclin [SEP] Clinical evaluation on combined administration of oral prostacyclin analogue beraprost and phosphodiesterase inhibitor cilostazol.", "tokenized_content": [2, 4876, 23689, 1921, 3, 2535, 4391, 1990, 4252, 4183, 1927, 4726, 4876, 23689, 1921, 12980, 8310, 21358, 2259, 1930, 24821, 4106, 12127, 2259, 10457, 18, 3]}, "items": [{"id": "p_476", "content": "Epoprostenol [SEP] A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTA", "score": 1, "type": null, "tokenized_content": [2, 15751, 2216, 24690, 1945, 3, 43, 15900, 1988, 1977, 43, 9974, 28194, 1930, 7042, 7163, 7883, 18, 2176, 1977, 7067, 4958, 23958, 2037, 4876, 1019, 3]}]}
{"query": {"id": "q_477", "content": "beraprost [SEP] uation on combined administration of oral prostacyclin analogue beraprost and phosphodiesterase inhibitor cilostazol.", "tokenized_content": [2, 8310, 21358, 2259, 3, 17942, 1929, 1990, 4252, 4183, 1927, 4726, 4876, 23689, 1921, 12980, 8310, 21358, 2259, 1930, 24821, 4106, 12127, 2259, 10457, 18, 3]}, "items": [{"id": "p_477", "content": "beraprost [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8310, 21358, 2259, 3, 3]}]}
{"query": {"id": "q_478", "content": "cilostazol [SEP] prostacyclin analogue beraprost and phosphodiesterase inhibitor cilostazol.", "tokenized_content": [2, 12127, 2259, 10457, 3, 4876, 23689, 1921, 12980, 8310, 21358, 2259, 1930, 24821, 4106, 12127, 2259, 10457, 18, 3]}, "items": [{"id": "p_478", "content": "cilostazol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12127, 2259, 10457, 3, 3]}]}
{"query": {"id": "q_479", "content": "prostacyclin [SEP] Among various oral antiplatelets, a combination of a novel prostacyclin analogue beraprost (BPT) and a potent phosphodiesterase inhibit", "tokenized_content": [2, 4876, 23689, 1921, 3, 2706, 3425, 4726, 21348, 1036, 16, 43, 3921, 1927, 43, 4008, 4876, 23689, 1921, 12980, 8310, 21358, 2259, 12, 4149, 1031, 13, 1930, 43, 6828, 24821, 3]}, "items": [{"id": "p_479", "content": "Epoprostenol [SEP] A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTA", "score": 1, "type": null, "tokenized_content": [2, 15751, 2216, 24690, 1945, 3, 43, 15900, 1988, 1977, 43, 9974, 28194, 1930, 7042, 7163, 7883, 18, 2176, 1977, 7067, 4958, 23958, 2037, 4876, 1019, 3]}]}
{"query": {"id": "q_480", "content": "beraprost [SEP] l antiplatelets, a combination of a novel prostacyclin analogue beraprost (BPT) and a potent phosphodiesterase inhibitor cilostazol (CLZ)", "tokenized_content": [2, 8310, 21358, 2259, 3, 54, 21348, 1036, 16, 43, 3921, 1927, 43, 4008, 4876, 23689, 1921, 12980, 8310, 21358, 2259, 12, 4149, 1031, 13, 1930, 43, 6828, 24821, 4106, 12127, 3]}, "items": [{"id": "p_480", "content": "beraprost [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8310, 21358, 2259, 3, 3]}]}
{"query": {"id": "q_481", "content": "BPT [SEP] lets, a combination of a novel prostacyclin analogue beraprost (BPT) and a potent phosphodiesterase inhibitor cilostazol (CLZ) may ", "tokenized_content": [2, 4149, 1031, 3, 6307, 1036, 16, 43, 3921, 1927, 43, 4008, 4876, 23689, 1921, 12980, 8310, 21358, 2259, 12, 4149, 1031, 13, 1930, 43, 6828, 24821, 4106, 12127, 2259, 10457, 3]}, "items": [{"id": "p_481", "content": "beraprost [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8310, 21358, 2259, 3, 3]}]}
{"query": {"id": "q_482", "content": "cilostazol [SEP] alogue beraprost (BPT) and a potent phosphodiesterase inhibitor cilostazol (CLZ) may result in untoward clinical effects due to possible s", "tokenized_content": [2, 12127, 2259, 10457, 3, 1969, 2021, 2182, 8310, 21358, 2259, 12, 4149, 1031, 13, 1930, 43, 6828, 24821, 4106, 12127, 2259, 10457, 12, 2111, 1011, 13, 2278, 3211, 1922, 18472, 3]}, "items": [{"id": "p_482", "content": "cilostazol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12127, 2259, 10457, 3, 3]}]}
{"query": {"id": "q_483", "content": "CLZ [SEP] rost (BPT) and a potent phosphodiesterase inhibitor cilostazol (CLZ) may result in untoward clinical effects due to possible synerg", "tokenized_content": [2, 2111, 1011, 3, 29539, 12, 4149, 1031, 13, 1930, 43, 6828, 24821, 4106, 12127, 2259, 10457, 12, 2111, 1011, 13, 2278, 3211, 1922, 18472, 20572, 8544, 2535, 2564, 2810, 1942, 3]}, "items": [{"id": "p_483", "content": "cilostazol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12127, 2259, 10457, 3, 3]}]}
{"query": {"id": "q_484", "content": "cAMP [SEP]  effects due to possible synergistic elevation of intracellular cAMP (cyclic adenosine 3',5'-monophosphate). Thereby, a clinical stu", "tokenized_content": [2, 6225, 3, 2564, 2810, 1942, 3216, 11322, 8644, 1927, 4776, 6225, 12, 9821, 10125, 23, 11, 16, 25, 11, 17, 21363, 13, 18, 6113, 16, 43, 2535, 1955, 1032, 3]}, "items": [{"id": "p_484", "content": "Cyclic AMP [SEP] An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. I", "score": 1, "type": null, "tokenized_content": [2, 9821, 3681, 3, 1925, 15643, 5489, 3165, 2340, 5413, 2210, 2154, 1977, 9603, 2828, 1942, 2321, 1920, 23, 11, 17, 1930, 25, 11, 17, 6490, 1927, 1920, 9523, 11804, 18, 51, 3]}]}
{"query": {"id": "q_485", "content": "cyclic adenosine 3',5'-monophosphate [SEP] ts due to possible synergistic elevation of intracellular cAMP (cyclic adenosine 3',5'-monophosphate). Thereby, a clinical study of the combined administration of t", "tokenized_content": [2, 9821, 10125, 23, 11, 16, 25, 11, 17, 21363, 3, 4894, 2810, 1942, 3216, 11322, 8644, 1927, 4776, 6225, 12, 9821, 10125, 23, 11, 16, 25, 11, 17, 21363, 13, 3]}, "items": [{"id": "p_485", "content": "Cyclic AMP [SEP] An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. I", "score": 1, "type": null, "tokenized_content": [2, 9821, 3681, 3, 1925, 15643, 5489, 3165, 2340, 5413, 2210, 2154, 1977, 9603, 2828, 1942, 2321, 1920, 23, 11, 17, 1930, 25, 11, 17, 6490, 1927, 1920, 9523, 11804, 18, 51, 3]}]}
{"query": {"id": "q_486", "content": "platelet aggregation [SEP] ntervals, physical examination and blood collection for ex vivo platelet aggregation and determination of intraplatelet cAMP were performed. Through", "tokenized_content": [2, 7163, 7883, 3, 5891, 3721, 2472, 16, 3841, 4981, 1930, 2877, 4957, 1958, 1975, 3597, 7163, 7883, 1930, 7063, 1927, 17817, 5148, 2057, 6088, 6225, 1985, 2593, 18, 2596, 3]}, "items": [{"id": "p_486", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_487", "content": "headache [SEP]  vital signs was observed. Seven out of 12 subjects experienced headache of a short duration accompanying facial flush in one and nausea", "tokenized_content": [2, 12187, 3, 8970, 6879, 1982, 2528, 18, 5260, 2397, 1927, 2369, 3297, 6090, 12187, 1927, 43, 3662, 4392, 15252, 9567, 2848, 6150, 1922, 2340, 1930, 13759, 3]}, "items": [{"id": "p_487", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_488", "content": "facial flush [SEP]  subjects experienced headache of a short duration accompanying facial flush in one and nausea in one, especially after ingestion of CLZ. Al", "tokenized_content": [2, 9567, 2848, 6150, 3, 3297, 6090, 12187, 1927, 43, 3662, 4392, 15252, 9567, 2848, 6150, 1922, 2340, 1930, 13759, 1922, 2340, 16, 4369, 2256, 14195, 1927, 2111, 1011, 18, 1969, 3]}, "items": [{"id": "p_488", "content": "Flushing [SEP] A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 6150, 1941, 3, 43, 6809, 2312, 5233, 1941, 1927, 1920, 6171, 1988, 2278, 1998, 2810, 1942, 9087, 16, 4908, 4195, 16, 28187, 16, 3071, 16, 2014, 43, 2573, 2585, 18, 3]}]}
{"query": {"id": "q_489", "content": "nausea [SEP] adache of a short duration accompanying facial flush in one and nausea in one, especially after ingestion of CLZ. All of these symptom", "tokenized_content": [2, 13759, 3, 20357, 15404, 1927, 43, 3662, 4392, 15252, 9567, 2848, 6150, 1922, 2340, 1930, 13759, 1922, 2340, 16, 4369, 2256, 14195, 1927, 2111, 1011, 18, 2136, 1927, 2144, 3226, 3]}, "items": [{"id": "p_489", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_490", "content": "etoricoxib [SEP] Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs ", "tokenized_content": [2, 2140, 18151, 19368, 3, 8375, 17934, 1927, 2140, 18151, 19368, 1922, 13053, 8884, 2132, 30, 2274, 1927, 1920, 2140, 18151, 19368, 3201, 3]}, "items": [{"id": "p_490", "content": "etoricoxib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2140, 18151, 19368, 3, 3]}]}
{"query": {"id": "q_491", "content": "rheumatoid arthritis [SEP] Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastro", "tokenized_content": [2, 13053, 8884, 3, 8375, 17934, 1927, 2140, 18151, 19368, 1922, 13053, 8884, 2132, 30, 2274, 1927, 1920, 2140, 18151, 19368, 3201, 27304, 5227, 6858, 3]}, "items": [{"id": "p_491", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_492", "content": "diclofenac sodium [SEP]  in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II)", "tokenized_content": [2, 27304, 5227, 3, 1922, 13053, 8884, 2132, 30, 2274, 1927, 1920, 2140, 18151, 19368, 3201, 27304, 5227, 8375, 17934, 1930, 6001, 3046, 12, 8269, 17, 2890, 13, 3]}, "items": [{"id": "p_492", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_493", "content": "etoricoxib [SEP]  the gastrointestinal (GI) tolerability, safety and efficacy of etoricoxib and diclofenac in patients with rheumatoid arthritis (RA). PATI", "tokenized_content": [2, 2140, 18151, 19368, 3, 1920, 8375, 12, 7217, 13, 17934, 16, 5407, 1930, 4348, 1927, 2140, 18151, 19368, 1930, 27304, 1922, 2132, 1956, 13053, 8884, 12, 4313, 13, 18, 2091, 3]}, "items": [{"id": "p_493", "content": "etoricoxib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2140, 18151, 19368, 3, 3]}]}
{"query": {"id": "q_494", "content": "diclofenac [SEP] stinal (GI) tolerability, safety and efficacy of etoricoxib and diclofenac in patients with rheumatoid arthritis (RA). PATIENTS AND METHOD", "tokenized_content": [2, 27304, 3, 6334, 3163, 12, 7217, 13, 17934, 16, 5407, 1930, 4348, 1927, 2140, 18151, 19368, 1930, 27304, 1922, 2132, 1956, 13053, 8884, 12, 4313, 13, 18, 2132, 1930, 2417, 3]}, "items": [{"id": "p_494", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_495", "content": "rheumatoid arthritis [SEP] fety and efficacy of etoricoxib and diclofenac in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS: A total of 4086 patients (mean age ", "tokenized_content": [2, 13053, 8884, 3, 9611, 1012, 1930, 4348, 1927, 2140, 18151, 19368, 1930, 27304, 1922, 2132, 1956, 13053, 8884, 12, 4313, 13, 18, 2132, 1930, 2860, 30, 43, 2698, 1927, 28759, 3]}, "items": [{"id": "p_495", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_496", "content": "RA [SEP] toricoxib and diclofenac in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS: A total of 4086 patients (mean age 60.8", "tokenized_content": [2, 4313, 3, 8184, 5670, 18068, 1014, 1930, 27304, 1922, 2132, 1956, 13053, 8884, 12, 4313, 13, 18, 2132, 1930, 2860, 30, 43, 2698, 1927, 28759, 1016, 2132, 12, 2667, 2632, 3]}, "items": [{"id": "p_496", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_497", "content": "aspirin [SEP] e daily (n = 2054). Use of gastroprotective agents and low-dose aspirin was allowed. The prespecified primary end point consisted of th", "tokenized_content": [2, 12396, 3, 47, 4692, 12, 56, 33, 15700, 1006, 13, 18, 2485, 1927, 6858, 9218, 2451, 4820, 1930, 2330, 17, 3253, 12396, 1982, 5563, 18, 1920, 2244, 3920, 2828, 3065, 3]}, "items": [{"id": "p_497", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_498", "content": "thrombotic cardiovascular [SEP]  (AEs). General safety was also assessed, including adjudicated thrombotic cardiovascular event data. Efficacy was evaluated using the Patient Global Ass", "tokenized_content": [2, 21039, 5321, 3, 12, 12893, 13, 18, 3335, 5407, 1982, 2222, 3683, 16, 2710, 3250, 16698, 11281, 1919, 21039, 5321, 4817, 2230, 18, 4348, 1982, 3747, 2193, 1920, 2774, 4906, 3]}, "items": [{"id": "p_498", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_499", "content": "GI AEs [SEP] roups, respectively. The cumulative discontinuation rate due to GI AEs was significantly lower with etoricoxib than diclofenac (5.2 vs", "tokenized_content": [2, 7217, 12893, 3, 5828, 2523, 16, 2763, 18, 1920, 8274, 14775, 2769, 2810, 1942, 7217, 12893, 1982, 2567, 2826, 1956, 2140, 18151, 19368, 2254, 27304, 12, 25, 18, 22, 3201, 3]}, "items": [{"id": "p_499", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_500", "content": "hypertension [SEP] 0.47, 0.81; p<or=0.001)). The incidence of discontinuations for hypertension-related and oedema-related AEs were significantly higher with e", "tokenized_content": [2, 5579, 3, 20, 18, 4261, 16, 20, 18, 6206, 31, 58, 32, 2014, 33, 20, 18, 3472, 13, 13, 18, 1920, 4332, 1927, 14775, 1036, 1958, 5579, 17, 2712, 1930, 3]}, "items": [{"id": "p_500", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_501", "content": "oedema [SEP]  The incidence of discontinuations for hypertension-related and oedema-related AEs were significantly higher with etoricoxib (2.5% and", "tokenized_content": [2, 24110, 3, 1920, 4332, 1927, 14775, 1036, 1958, 5579, 17, 2712, 1930, 24110, 17, 2712, 12893, 1985, 2567, 2580, 1956, 2140, 18151, 19368, 12, 22, 18, 25, 9, 1930, 3]}, "items": [{"id": "p_501", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_502", "content": "Etoricoxib [SEP]  respectively; p<0.001 for hypertension and p<0.01 for oedema). Etoricoxib and diclofenac treatment resulted in similar efficacy (PGADS me", "tokenized_content": [2, 2140, 18151, 19368, 3, 2763, 31, 58, 32, 20, 18, 3472, 1958, 5579, 1930, 58, 32, 20, 18, 3287, 1958, 24110, 13, 18, 2140, 18151, 19368, 1930, 27304, 2311, 4306, 3]}, "items": [{"id": "p_502", "content": "etoricoxib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2140, 18151, 19368, 3, 3]}]}
{"query": {"id": "q_503", "content": "extrapyramidal symptoms [SEP] Placebo-level incidence of extrapyramidal symptoms (EPS) with quetiapine in controlled studies of patients with bi", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 5936, 17, 2237, 4332, 1927, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 1956, 10730, 11574, 12184, 1922, 4642, 2351, 1927, 2132, 1956, 2273, 3]}, "items": [{"id": "p_503", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_504", "content": "EPS [SEP] Placebo-level incidence of extrapyramidal symptoms (EPS) with quetiapine in controlled studies of patients with bipolar", "tokenized_content": [2, 9178, 3, 5936, 17, 2237, 4332, 1927, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 1956, 10730, 11574, 12184, 1922, 4642, 2351, 1927, 2132, 1956, 10275, 3]}, "items": [{"id": "p_504", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_505", "content": "quetiapine [SEP] Placebo-level incidence of extrapyramidal symptoms (EPS) with quetiapine in controlled studies of patients with bipolar mania.", "tokenized_content": [2, 10730, 11574, 12184, 3, 5936, 17, 2237, 4332, 1927, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 1956, 10730, 11574, 12184, 1922, 4642, 2351, 1927, 2132, 1956, 10275, 28864, 18, 3]}, "items": [{"id": "p_505", "content": "quetiapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10730, 11574, 12184, 3, 3]}]}
{"query": {"id": "q_506", "content": "bipolar mania [SEP] ms (EPS) with quetiapine in controlled studies of patients with bipolar mania.", "tokenized_content": [2, 10275, 28864, 3, 3012, 12, 9178, 13, 1956, 10730, 11574, 12184, 1922, 4642, 2351, 1927, 2132, 1956, 10275, 28864, 18, 3]}, "items": [{"id": "p_506", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_507", "content": "extrapyramidal symptoms [SEP] OBJECTIVES: To evaluate extrapyramidal symptoms (EPS), including akathisia, with quetiapine in patients with bi", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 7634, 30, 1942, 4323, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 2710, 4464, 2183, 1937, 2126, 16, 1956, 10730, 11574, 12184, 1922, 3]}, "items": [{"id": "p_507", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_508", "content": "EPS [SEP] OBJECTIVES: To evaluate extrapyramidal symptoms (EPS), including akathisia, with quetiapine in patients with bipolar", "tokenized_content": [2, 9178, 3, 7634, 30, 1942, 4323, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 2710, 4464, 2183, 1937, 2126, 16, 1956, 10730, 11574, 12184, 1922, 2132, 1956, 10275, 3]}, "items": [{"id": "p_508", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_509", "content": "akathisia [SEP] BJECTIVES: To evaluate extrapyramidal symptoms (EPS), including akathisia, with quetiapine in patients with bipolar mania. METHODS: Data ", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 17840, 6596, 30, 1942, 4323, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 2710, 4464, 2183, 1937, 2126, 16, 1956, 10730, 11574, 12184, 1922, 3]}, "items": [{"id": "p_509", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_510", "content": "quetiapine [SEP] aluate extrapyramidal symptoms (EPS), including akathisia, with quetiapine in patients with bipolar mania. METHODS: Data were analyzed fro", "tokenized_content": [2, 10730, 11574, 12184, 3, 24664, 2010, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 2710, 4464, 2183, 1937, 2126, 16, 1956, 10730, 11574, 12184, 1922, 2132, 1956, 10275, 28864, 3]}, "items": [{"id": "p_510", "content": "quetiapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10730, 11574, 12184, 3, 3]}]}
{"query": {"id": "q_511", "content": "bipolar mania [SEP] ms (EPS), including akathisia, with quetiapine in patients with bipolar mania. METHODS: Data were analyzed from four similarly designed, rand", "tokenized_content": [2, 10275, 28864, 3, 3012, 12, 9178, 13, 16, 2710, 4464, 2183, 1937, 2126, 16, 1956, 10730, 11574, 12184, 1922, 2132, 1956, 10275, 28864, 18, 2860, 30, 2230, 1985, 3265, 2037, 3]}, "items": [{"id": "p_511", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_512", "content": "lithium [SEP] apy (up to 800 mg/day) (n = 209) versus placebo (n = 198), with lithium or haloperidol monotherapy as respective active controls. Two s", "tokenized_content": [2, 14330, 3, 2100, 1012, 12, 2353, 1942, 9658, 2786, 19, 3007, 13, 12, 56, 33, 18001, 13, 4072, 5936, 12, 56, 33, 3972, 13, 16, 1956, 14330, 2014, 25107, 13767, 3]}, "items": [{"id": "p_512", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_513", "content": "haloperidol [SEP] 800 mg/day) (n = 209) versus placebo (n = 198), with lithium or haloperidol monotherapy as respective active controls. Two studies evaluate", "tokenized_content": [2, 25107, 3, 9658, 2786, 19, 3007, 13, 12, 56, 33, 18001, 13, 4072, 5936, 12, 56, 33, 3972, 13, 16, 1956, 14330, 2014, 25107, 13767, 1966, 7025, 3500, 3562, 18, 3]}, "items": [{"id": "p_513", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_514", "content": "divalproex [SEP] o 800 mg/day) in combination with a mood stabilizer (lithium or divalproex, QTP + Li/DVP) (n = 196) compared to placebo and mood stabilize", "tokenized_content": [2, 6421, 1923, 2216, 2783, 3, 57, 9658, 2786, 19, 3007, 13, 1922, 3921, 1956, 43, 9494, 13448, 1005, 12, 14330, 2014, 6421, 1923, 2216, 2783, 16, 8877, 1034, 15, 2336, 3]}, "items": [{"id": "p_514", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_515", "content": "QTP [SEP] ) in combination with a mood stabilizer (lithium or divalproex, QTP + Li/DVP) (n = 196) compared to placebo and mood stabilizer (PB", "tokenized_content": [2, 8877, 1034, 3, 13, 1922, 3921, 1956, 43, 9494, 13448, 1005, 12, 14330, 2014, 6421, 1923, 2216, 2783, 16, 8877, 1034, 15, 2336, 19, 11203, 1034, 13, 12, 56, 33, 3]}, "items": [{"id": "p_515", "content": "quetiapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10730, 11574, 12184, 3, 3]}]}
{"query": {"id": "q_516", "content": "Li [SEP] ombination with a mood stabilizer (lithium or divalproex, QTP + Li/DVP) (n = 196) compared to placebo and mood stabilizer (PBO + L", "tokenized_content": [2, 2336, 3, 7254, 23605, 1943, 1956, 43, 9494, 13448, 1005, 12, 14330, 2014, 6421, 1923, 2216, 2783, 16, 8877, 1034, 15, 2336, 19, 11203, 1034, 13, 12, 56, 33, 16841, 3]}, "items": [{"id": "p_516", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_517", "content": "DVP [SEP] ination with a mood stabilizer (lithium or divalproex, QTP + Li/DVP) (n = 196) compared to placebo and mood stabilizer (PBO + Li/DV", "tokenized_content": [2, 11203, 1034, 3, 26851, 1929, 1956, 43, 9494, 13448, 1005, 12, 14330, 2014, 6421, 1923, 2216, 2783, 16, 8877, 1034, 15, 2336, 19, 11203, 1034, 13, 12, 56, 33, 16841, 3]}, "items": [{"id": "p_517", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_518", "content": "Extrapyramidal symptoms [SEP] mpared to placebo and mood stabilizer (PBO + Li/DVP) (n = 203). Extrapyramidal symptoms were evaluated using the Simpson-Angus Scale (SAS), the Barnes ", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 12888, 3510, 1942, 5936, 1930, 9494, 13448, 1005, 12, 5242, 1037, 15, 2336, 19, 11203, 1034, 13, 12, 56, 33, 16725, 13, 18, 21346, 3]}, "items": [{"id": "p_518", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_519", "content": "Lithium [SEP] o (6.1%), and with QTP + Li/DVP (3.6%) and PBO + Li/DVP (4.9%). Lithium was associated with a significantly higher incidence (p < 0.05)", "tokenized_content": [2, 14330, 3, 57, 12, 26, 18, 21, 9, 13, 16, 1930, 1956, 8877, 1034, 15, 2336, 19, 11203, 1034, 12, 23, 18, 26, 9, 13, 1930, 5242, 1037, 15, 2336, 3]}, "items": [{"id": "p_519", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_520", "content": "tremor [SEP]  associated with a significantly higher incidence (p < 0.05) of tremor (18.4%) than quetiapine (5.6%); cerebellar tremor, which is a k", "tokenized_content": [2, 18388, 3, 2458, 1956, 43, 2567, 2580, 4332, 12, 58, 32, 20, 18, 2914, 13, 1927, 18388, 12, 2654, 18, 24, 9, 13, 2254, 10730, 11574, 12184, 12, 25, 18, 3]}, "items": [{"id": "p_520", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_521", "content": "Haloperidol [SEP]  elevated rate of tremor in patients receiving lithium therapy. Haloperidol induced a significantly higher incidence (p < 0.001) of akathis", "tokenized_content": [2, 25107, 3, 4664, 2769, 1927, 18388, 1922, 2132, 5962, 14330, 3181, 18, 25107, 2719, 43, 2567, 2580, 4332, 12, 58, 32, 20, 18, 3472, 13, 1927, 4464, 2183, 1937, 3]}, "items": [{"id": "p_521", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_522", "content": "extrapyramidal syndrome [SEP]  akathisia (33.3% versus 5.9%), tremor (30.3% versus 7.8%), and extrapyramidal syndrome (35.4% versus 5.9%) than quetiapine. No significant differences", "tokenized_content": [2, 21346, 3553, 25238, 1923, 4741, 3, 4464, 2183, 1937, 2126, 12, 3401, 18, 23, 9, 4072, 25, 18, 29, 9, 13, 16, 18388, 12, 2627, 18, 23, 9, 4072, 27, 3]}, "items": [{"id": "p_522", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_523", "content": "captopril [SEP]  the sympathetic nervous system to salt-sensitivity in lifetime captopril-treated spontaneously hypertensive rats.", "tokenized_content": [2, 7502, 24863, 3, 1920, 11739, 7580, 2433, 1942, 7012, 17, 3802, 1922, 9416, 7502, 24863, 17, 2868, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_523", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_524", "content": "hypertensive [SEP] to salt-sensitivity in lifetime captopril-treated spontaneously hypertensive rats.", "tokenized_content": [2, 11706, 3, 1942, 7012, 17, 3802, 1922, 9416, 7502, 24863, 17, 2868, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_524", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_525", "content": "captopril [SEP] OBJECTIVE: To test the hypothesis that, in lifetime captopril-treated spontaneously hypertensive rats (SHR), the sympathetic ", "tokenized_content": [2, 7502, 24863, 3, 4470, 30, 1942, 2648, 1920, 4676, 1988, 16, 1922, 9416, 7502, 24863, 17, 2868, 12753, 11706, 3615, 12, 6606, 13, 16, 1920, 11739, 3]}, "items": [{"id": "p_525", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_526", "content": "hypertensive [SEP] he hypothesis that, in lifetime captopril-treated spontaneously hypertensive rats (SHR), the sympathetic nervous system contributes importan", "tokenized_content": [2, 11706, 3, 2234, 4676, 1988, 16, 1922, 9416, 7502, 24863, 17, 2868, 12753, 11706, 3615, 12, 6606, 13, 16, 1920, 11739, 7580, 2433, 7624, 2582, 1928, 3]}, "items": [{"id": "p_526", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_527", "content": "dietary sodium chloride [SEP] us system contributes importantly to the hypertensive effect of dietary sodium chloride supplementation. METHODS: Male SHR (aged 6 weeks) that had been", "tokenized_content": [2, 6096, 5227, 9140, 3, 2022, 2433, 7624, 6444, 1942, 1920, 11706, 2495, 1927, 6096, 5227, 9140, 8746, 18, 2860, 30, 4005, 6606, 12, 5177, 26, 3625, 13, 1988, 2430, 2252, 3]}, "items": [{"id": "p_527", "content": "Sodium Chloride, Dietary [SEP] Sodium chloride used in foods.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 9140, 16, 6096, 3, 5227, 9140, 2251, 1922, 9660, 18, 3]}]}
{"query": {"id": "q_528", "content": "sodium chloride [SEP] m contributes importantly to the hypertensive effect of dietary sodium chloride supplementation. METHODS: Male SHR (aged 6 weeks) that had been", "tokenized_content": [2, 5227, 9140, 3, 55, 7624, 6444, 1942, 1920, 11706, 2495, 1927, 6096, 5227, 9140, 8746, 18, 2860, 30, 4005, 6606, 12, 5177, 26, 3625, 13, 1988, 2430, 2252, 3]}, "items": [{"id": "p_528", "content": "Sodium Chloride [SEP] A ubiquitous sodium salt that is commonly used to season food.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 9140, 3, 43, 15498, 5227, 7012, 1988, 1977, 5384, 2251, 1942, 9520, 3959, 18, 3]}]}
{"query": {"id": "q_529", "content": "clonidine [SEP] bjected to ganglionic blockade and 2 days later, an infusion of clonidine. RESULTS: Lifetime captopril treatment significantly lowered me", "tokenized_content": [2, 26596, 3, 17840, 2207, 1942, 12516, 1935, 9847, 1930, 22, 3000, 3690, 16, 1925, 7386, 1927, 26596, 18, 2274, 30, 9416, 7502, 24863, 2311, 2567, 13786, 2142, 3]}, "items": [{"id": "p_529", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_530", "content": "hexamethonium [SEP]  in both groups. Intravenous infusion of the ganglionic blocker hexamethonium resulted in a rapid decline in MAP that eliminated the dietary ", "tokenized_content": [2, 7142, 10758, 15414, 3, 1922, 2321, 2671, 18, 7307, 7386, 1927, 1920, 12516, 1935, 14580, 7142, 10758, 15414, 4306, 1922, 43, 4052, 6859, 1922, 4446, 1988, 11412, 1920, 6096, 3]}, "items": [{"id": "p_530", "content": "Hexamethonium [SEP] A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gast", "score": 1, "type": null, "tokenized_content": [2, 7142, 10758, 15414, 3, 43, 20239, 13908, 8151, 3868, 6656, 1942, 1966, 1920, 29183, 12516, 1935, 14580, 18, 2176, 1977, 7865, 14504, 2037, 1920, 6215, 3]}]}
{"query": {"id": "q_531", "content": "increase in MAP [SEP] line in MAP that eliminated the dietary sodium chloride-induced increase in MAP in both groups. Infusion of the central nervous system alpha2-a", "tokenized_content": [2, 2760, 1922, 4446, 3, 2823, 1922, 4446, 1988, 11412, 1920, 6096, 5227, 9140, 17, 2719, 2760, 1922, 4446, 1922, 2321, 2671, 18, 7386, 1927, 1920, 4101, 7580, 2433, 4595, 1028, 3]}, "items": [{"id": "p_531", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_532", "content": "alpha2-adrenergic receptor agonist [SEP] e in MAP in both groups. Infusion of the central nervous system alpha2-adrenergic receptor agonist clonidine also resulted in a greater reduction in MAP in both g", "tokenized_content": [2, 4595, 1028, 17, 13672, 3148, 7829, 3, 47, 1922, 4446, 1922, 2321, 2671, 18, 7386, 1927, 1920, 4101, 7580, 2433, 4595, 1028, 17, 13672, 3148, 7829, 26596, 2222, 4306, 1922, 3]}, "items": [{"id": "p_532", "content": "Adrenergic alpha-2 Receptor Agonists [SEP] Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13672, 4595, 17, 22, 3148, 9849, 3, 4300, 1988, 4566, 1942, 1930, 6980, 13672, 4595, 17, 22, 4086, 18, 3]}]}
{"query": {"id": "q_533", "content": "corticosterone [SEP] Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.", "tokenized_content": [2, 18136, 3, 3253, 17, 2712, 6928, 1930, 5246, 2564, 1927, 6096, 18136, 1990, 3090, 16847, 1957, 17, 2719, 7083, 13177, 1922, 16667, 18, 3]}, "items": [{"id": "p_533", "content": "Corticosterone [SEP] An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman ", "score": 1, "type": null, "tokenized_content": [2, 18136, 3, 1925, 7206, 16557, 9507, 1988, 2258, 9194, 2308, 2228, 4209, 1966, 43, 8463, 10323, 2642, 1930, 43, 14469, 18, 12, 2037, 4227, 3862, 3]}]}
{"query": {"id": "q_534", "content": "organophosphorus [SEP] ted beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.", "tokenized_content": [2, 3090, 16847, 1957, 3, 26080, 6928, 1930, 5246, 2564, 1927, 6096, 18136, 1990, 3090, 16847, 1957, 17, 2719, 7083, 13177, 1922, 16667, 18, 3]}, "items": [{"id": "p_534", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_535", "content": "neuropathy [SEP] s of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.", "tokenized_content": [2, 13177, 3, 61, 1927, 6096, 18136, 1990, 3090, 16847, 1957, 17, 2719, 7083, 13177, 1922, 16667, 18, 3]}, "items": [{"id": "p_535", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_536", "content": "Tri-ortho-tolyl phosphate [SEP] Tri-ortho-tolyl phosphate (TOTP), 360 mg/kg, po, and 0,0'-diisopropyl phosphorofluoridate", "tokenized_content": [2, 5083, 17, 24343, 17, 21930, 2199, 5413, 3, 5083, 17, 24343, 17, 21930, 2199, 5413, 12, 13877, 1034, 13, 16, 15533, 2786, 19, 3621, 16, 2510, 16, 1930, 20, 16, 3]}, "items": [{"id": "p_536", "content": "tri-o-cresyl phosphate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17, 57, 17, 18401, 2199, 5413, 3, 3]}]}
{"query": {"id": "q_537", "content": "TOTP [SEP] Tri-ortho-tolyl phosphate (TOTP), 360 mg/kg, po, and 0,0'-diisopropyl phosphorofluoridate (DFP)", "tokenized_content": [2, 13877, 1034, 3, 5083, 17, 24343, 17, 21930, 2199, 5413, 12, 13877, 1034, 13, 16, 15533, 2786, 19, 3621, 16, 2510, 16, 1930, 20, 16, 20, 11, 17, 26028, 2204, 3]}, "items": [{"id": "p_537", "content": "tri-o-cresyl phosphate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17, 57, 17, 18401, 2199, 5413, 3, 3]}]}
{"query": {"id": "q_538", "content": "0,0'-diisopropyl phosphorofluoridate [SEP] Tri-ortho-tolyl phosphate (TOTP), 360 mg/kg, po, and 0,0'-diisopropyl phosphorofluoridate (DFP), 1 mg/kg sc, were administered to adult White Leghorn chi", "tokenized_content": [2, 20, 16, 20, 11, 17, 26028, 2204, 20194, 2199, 3421, 4199, 11525, 21550, 3, 5083, 17, 24343, 17, 21930, 2199, 5413, 12, 13877, 1034, 13, 16, 15533, 2786, 19, 3621, 3]}, "items": [{"id": "p_538", "content": "Isoflurophate [SEP] A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4911, 12353, 2688, 2010, 3, 43, 2137, 17, 20500, 17, 16191, 25324, 2154, 1977, 1925, 14104, 15440, 2156, 7124, 4127, 4106, 2251, 1942, 4482, 1920, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_539", "content": "DFP [SEP] TOTP), 360 mg/kg, po, and 0,0'-diisopropyl phosphorofluoridate (DFP), 1 mg/kg sc, were administered to adult White Leghorn chickens", "tokenized_content": [2, 8122, 1034, 3, 13877, 1034, 13, 16, 15533, 2786, 19, 3621, 16, 2510, 16, 1930, 20, 16, 20, 11, 17, 26028, 2204, 20194, 2199, 3421, 4199, 11525, 21550, 12, 8122, 3]}, "items": [{"id": "p_539", "content": "Isoflurophate [SEP] A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4911, 12353, 2688, 2010, 3, 43, 2137, 17, 20500, 17, 16191, 25324, 2154, 1977, 1925, 14104, 15440, 2156, 7124, 4127, 4106, 2251, 1942, 4482, 1920, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_540", "content": "corticosterone [SEP] s 24 hr after they were placed on diets containing 0 to 300 ppm corticosterone. Supplemented diets were continued until clinical signs and les", "tokenized_content": [2, 18136, 3, 61, 2686, 3668, 2256, 2611, 1985, 5396, 1990, 10456, 3165, 20, 1942, 5255, 8748, 18136, 18, 6359, 10456, 1985, 7583, 4801, 2535, 6879, 1930, 3636, 3]}, "items": [{"id": "p_540", "content": "Corticosterone [SEP] An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman ", "score": 1, "type": null, "tokenized_content": [2, 18136, 3, 1925, 7206, 16557, 9507, 1988, 2258, 9194, 2308, 2228, 4209, 1966, 43, 8463, 10323, 2642, 1930, 43, 14469, 18, 12, 2037, 4227, 3862, 3]}]}
{"query": {"id": "q_541", "content": "neuropathy [SEP] iets were continued until clinical signs and lesions of delayed neuropathy appeared. Although low concentrations (less than or equal to 50", "tokenized_content": [2, 13177, 3, 10116, 1973, 1985, 7583, 4801, 2535, 6879, 1930, 4518, 1927, 7083, 13177, 6209, 18, 2876, 2330, 3295, 12, 2941, 2254, 2014, 5557, 1942, 2761, 3]}, "items": [{"id": "p_541", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_542", "content": "Neurotoxic [SEP] xacerbated clinical signs in chickens given either TOTP or DFP. Neurotoxic esterase activities 24 hr after TOTP or DFP were less than 20% ", "tokenized_content": [2, 20919, 3, 23447, 2337, 7972, 2013, 2535, 6879, 1922, 16667, 3258, 3108, 13877, 1034, 2014, 8122, 1034, 18, 20919, 26389, 4209, 2686, 3668, 2256, 13877, 1034, 2014, 8122, 1034, 1985, 3]}, "items": [{"id": "p_542", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_543", "content": "organophosphorous [SEP] DFP were less than 20% of values measured in chickens not given organophosphorous compounds. Chickens given 200 ppm corticosterone without TOTP o", "tokenized_content": [2, 3090, 16847, 2080, 3, 8122, 1034, 1985, 2941, 2254, 2036, 9, 1927, 2851, 3045, 1922, 16667, 2084, 3258, 3090, 16847, 2080, 4300, 18, 16667, 3258, 2191, 8748, 18136, 2979, 13877, 3]}, "items": [{"id": "p_543", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_544", "content": "Degenerating myelinated fibers [SEP] and significantly inhibited activity of liver carboxylesterase. Degenerating myelinated fibers were also evident in distal levels of the peripheral nerves of ", "tokenized_content": [2, 7223, 18577, 26321, 6989, 3, 1930, 2567, 5069, 2455, 1927, 3568, 9943, 8342, 2051, 18, 7223, 18577, 26321, 6989, 1985, 2222, 7501, 1922, 6583, 2428, 1927, 1920, 5009, 12014, 1927, 3]}, "items": [{"id": "p_544", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_545", "content": "adenosine A2A/A1 receptor antagonist [SEP] In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.", "tokenized_content": [2, 10125, 27045, 19, 8080, 3148, 8151, 3, 1922, 3597, 7285, 1927, 43, 7064, 10125, 27045, 19, 8080, 3148, 8151, 1922, 4027, 3130, 1927, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_545", "content": "Purinergic P1 Receptor Antagonists [SEP] Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19700, 1005, 11545, 8632, 3148, 10515, 3, 4300, 1988, 4566, 1942, 1930, 3367, 1920, 4177, 1927, 19700, 1005, 11545, 8632, 4086, 18, 3]}]}
{"query": {"id": "q_546", "content": "Parkinson's disease [SEP] a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 43, 7064, 10125, 27045, 19, 8080, 3148, 8151, 1922, 4027, 3130, 1927, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_546", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_547", "content": "adenosine A(2A)/A(1) receptor antagonist [SEP] The in vivo characterization of a dual adenosine A(2A)/A(1) receptor antagonist in several animal models of Parkinson's disease is described. D", "tokenized_content": [2, 10125, 43, 12, 5251, 13, 19, 43, 12, 21, 13, 3148, 8151, 3, 1920, 1922, 3597, 7285, 1927, 43, 7064, 10125, 43, 12, 5251, 13, 19, 43, 12, 21, 13, 3]}, "items": [{"id": "p_547", "content": "Purinergic P1 Receptor Antagonists [SEP] Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19700, 1005, 11545, 8632, 3148, 10515, 3, 4300, 1988, 4566, 1942, 1930, 3367, 1920, 4177, 1927, 19700, 1005, 11545, 8632, 4086, 18, 3]}]}
{"query": {"id": "q_548", "content": "Parkinson's disease [SEP] sine A(2A)/A(1) receptor antagonist in several animal models of Parkinson's disease is described. Discovery and scale-up syntheses of compound 1 ar", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 25736, 43, 12, 5251, 13, 19, 43, 12, 21, 13, 3148, 8151, 1922, 2980, 4027, 3130, 1927, 10124, 11, 61, 2573, 1977, 2910, 18, 7139, 3]}, "items": [{"id": "p_548", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_549", "content": "haloperidol [SEP] models of Parkinson's disease including mouse and rat models of haloperidol-induced catalepsy, mouse model of reserpine-induced akinesia, r", "tokenized_content": [2, 25107, 3, 3130, 1927, 10124, 11, 61, 2573, 2710, 3321, 1930, 3067, 3130, 1927, 25107, 17, 2719, 4233, 9431, 1012, 16, 3321, 2322, 1927, 1995, 1915, 12184, 17, 2719, 26162, 3]}, "items": [{"id": "p_549", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_550", "content": "catalepsy [SEP] s disease including mouse and rat models of haloperidol-induced catalepsy, mouse model of reserpine-induced akinesia, rat 6-hydroxydopami", "tokenized_content": [2, 4233, 9431, 1012, 3, 61, 2573, 2710, 3321, 1930, 3067, 3130, 1927, 25107, 17, 2719, 4233, 9431, 1012, 16, 3321, 2322, 1927, 1995, 1915, 12184, 17, 2719, 26162, 7156, 16, 3]}, "items": [{"id": "p_550", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_551", "content": "reserpine [SEP] and rat models of haloperidol-induced catalepsy, mouse model of reserpine-induced akinesia, rat 6-hydroxydopamine (6-OHDA) lesion model o", "tokenized_content": [2, 1995, 1915, 12184, 3, 1930, 3067, 3130, 1927, 25107, 17, 2719, 4233, 9431, 1012, 16, 3321, 2322, 1927, 1995, 1915, 12184, 17, 2719, 26162, 7156, 16, 3067, 26, 17, 8275, 3]}, "items": [{"id": "p_551", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_552", "content": "akinesia [SEP] haloperidol-induced catalepsy, mouse model of reserpine-induced akinesia, rat 6-hydroxydopamine (6-OHDA) lesion model of drug-induced ro", "tokenized_content": [2, 26162, 7156, 3, 25107, 17, 2719, 4233, 9431, 1012, 16, 3321, 2322, 1927, 1995, 1915, 12184, 17, 2719, 26162, 7156, 16, 3067, 26, 17, 8275, 22389, 4302, 25157, 12, 26, 3]}, "items": [{"id": "p_552", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_553", "content": "6-hydroxydopamine [SEP] duced catalepsy, mouse model of reserpine-induced akinesia, rat 6-hydroxydopamine (6-OHDA) lesion model of drug-induced rotation, and MPTP-treate", "tokenized_content": [2, 26, 17, 8275, 22389, 4302, 25157, 3, 10677, 1919, 4233, 9431, 1012, 16, 3321, 2322, 1927, 1995, 1915, 12184, 17, 2719, 26162, 7156, 16, 3067, 26, 17, 8275, 22389, 4302, 3]}, "items": [{"id": "p_553", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_554", "content": "6-OHDA [SEP] use model of reserpine-induced akinesia, rat 6-hydroxydopamine (6-OHDA) lesion model of drug-induced rotation, and MPTP-treated non-hu", "tokenized_content": [2, 26, 17, 25737, 3, 2485, 2322, 1927, 1995, 1915, 12184, 17, 2719, 26162, 7156, 16, 3067, 26, 17, 8275, 22389, 4302, 25157, 12, 26, 17, 25737, 13, 5709, 2322, 1927, 3]}, "items": [{"id": "p_554", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_555", "content": "MPTP [SEP] oxydopamine (6-OHDA) lesion model of drug-induced rotation, and MPTP-treated non-human primate model.", "tokenized_content": [2, 19043, 3, 20004, 22389, 4302, 25157, 12, 26, 17, 25737, 13, 5709, 2322, 1927, 2838, 17, 2719, 8891, 16, 1930, 19043, 17, 2868, 2447, 17, 2616, 16305, 2322, 18, 3]}, "items": [{"id": "p_555", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_556", "content": "delusional parasitosis [SEP] An extremely rare case of delusional parasitosis in a chronic hepatitis C patient during pegylated interferon al", "tokenized_content": [2, 2723, 2670, 1923, 16891, 2475, 3, 1925, 8113, 5844, 3087, 1927, 2723, 2670, 1923, 16891, 2475, 1922, 43, 3724, 7977, 45, 2774, 2409, 24208, 10001, 1969, 3]}, "items": [{"id": "p_556", "content": "Delusional Parasitosis [SEP] A delusional disorder of belief in infestation by insects or other parasites. This FORMICATION is typically accompanied by derma", "score": 1, "type": null, "tokenized_content": [2, 2723, 2670, 1923, 16891, 2475, 3, 43, 2723, 2670, 1923, 4770, 1927, 15366, 1922, 26731, 2007, 13340, 2014, 2303, 9687, 18, 2052, 17202, 1943, 1977, 5745, 7936, 2007, 8960, 1019, 3]}]}
{"query": {"id": "q_557", "content": "chronic hepatitis C [SEP] An extremely rare case of delusional parasitosis in a chronic hepatitis C patient during pegylated interferon alpha-2b and ribavirin trea", "tokenized_content": [2, 3724, 7977, 45, 3, 1925, 8113, 5844, 3087, 1927, 2723, 2670, 1923, 16891, 2475, 1922, 43, 3724, 7977, 45, 2774, 2409, 24208, 10001, 4595, 17, 5751, 1930, 23635, 2171, 1019, 3]}, "items": [{"id": "p_557", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_558", "content": "pegylated interferon alpha-2b [SEP]  delusional parasitosis in a chronic hepatitis C patient during pegylated interferon alpha-2b and ribavirin treatment.", "tokenized_content": [2, 24208, 10001, 4595, 17, 5751, 3, 2723, 2670, 1923, 16891, 2475, 1922, 43, 3724, 7977, 45, 2774, 2409, 24208, 10001, 4595, 17, 5751, 1930, 23635, 2311, 18, 3]}, "items": [{"id": "p_558", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_559", "content": "ribavirin [SEP] ic hepatitis C patient during pegylated interferon alpha-2b and ribavirin treatment.", "tokenized_content": [2, 23635, 3, 3996, 7977, 45, 2774, 2409, 24208, 10001, 4595, 17, 5751, 1930, 23635, 2311, 18, 3]}, "items": [{"id": "p_559", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_560", "content": "chronic hepatitis C [SEP] During treatment of chronic hepatitis C patients with interferon and ribavirin, a lot of side effects a", "tokenized_content": [2, 3724, 7977, 45, 3, 2409, 2311, 1927, 3724, 7977, 45, 2132, 1956, 10001, 1930, 23635, 16, 43, 12026, 1927, 4159, 2564, 43, 3]}, "items": [{"id": "p_560", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_561", "content": "ribavirin [SEP] g treatment of chronic hepatitis C patients with interferon and ribavirin, a lot of side effects are described. Twenty-three percent to 4", "tokenized_content": [2, 23635, 3, 49, 2311, 1927, 3724, 7977, 45, 2132, 1956, 10001, 1930, 23635, 16, 43, 12026, 1927, 4159, 2564, 2032, 2910, 18, 7639, 17, 2559, 3564, 1942, 24, 3]}, "items": [{"id": "p_561", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_562", "content": "depression [SEP]  are described. Twenty-three percent to 44% of patients develop depression. A minority of patients evolve to psychosis. To the best of our", "tokenized_content": [2, 4621, 3, 2032, 2910, 18, 7639, 17, 2559, 3564, 1942, 4044, 9, 1927, 2132, 2392, 4621, 18, 43, 11733, 1927, 2132, 17175, 1942, 15489, 18, 1942, 1920, 4534, 1927, 2342, 3]}, "items": [{"id": "p_562", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_563", "content": "psychosis [SEP] f patients develop depression. A minority of patients evolve to psychosis. To the best of our knowledge, no cases of psychogenic parasito", "tokenized_content": [2, 15489, 3, 48, 2132, 2392, 4621, 18, 43, 11733, 1927, 2132, 17175, 1942, 15489, 18, 1942, 1920, 4534, 1927, 2342, 4163, 16, 2239, 2919, 1927, 18740, 11216, 16891, 1037, 3]}, "items": [{"id": "p_563", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_564", "content": "psychogenic parasitosis [SEP]  evolve to psychosis. To the best of our knowledge, no cases of psychogenic parasitosis occurring during interferon therapy have been described in the ", "tokenized_content": [2, 18740, 11216, 16891, 2475, 3, 17175, 1942, 15489, 18, 1942, 1920, 4534, 1927, 2342, 4163, 16, 2239, 2919, 1927, 18740, 11216, 16891, 2475, 6966, 2409, 10001, 3181, 2162, 2252, 2910, 3]}, "items": [{"id": "p_564", "content": "Delusional Parasitosis [SEP] A delusional disorder of belief in infestation by insects or other parasites. This FORMICATION is typically accompanied by derma", "score": 1, "type": null, "tokenized_content": [2, 2723, 2670, 1923, 16891, 2475, 3, 43, 2723, 2670, 1923, 4770, 1927, 15366, 1922, 26731, 2007, 13340, 2014, 2303, 9687, 18, 2052, 17202, 1943, 1977, 5745, 7936, 2007, 8960, 1019, 3]}]}
{"query": {"id": "q_565", "content": "delusional parasitosis [SEP]  the literature. We present a 49-year-old woman who developed a delusional parasitosis during treatment with pegylated interferon alpha-2b weekly and ", "tokenized_content": [2, 2723, 2670, 1923, 16891, 2475, 3, 1920, 4431, 18, 2038, 2481, 43, 4343, 17, 2476, 17, 4156, 10440, 2746, 3530, 43, 2723, 2670, 1923, 16891, 2475, 2409, 2311, 1956, 24208, 3]}, "items": [{"id": "p_565", "content": "Delusional Parasitosis [SEP] A delusional disorder of belief in infestation by insects or other parasites. This FORMICATION is typically accompanied by derma", "score": 1, "type": null, "tokenized_content": [2, 2723, 2670, 1923, 16891, 2475, 3, 43, 2723, 2670, 1923, 4770, 1927, 15366, 1922, 26731, 2007, 13340, 2014, 2303, 9687, 18, 2052, 17202, 1943, 1977, 5745, 7936, 2007, 8960, 1019, 3]}]}
{"query": {"id": "q_566", "content": "pegylated interferon alpha-2b [SEP] an who developed a delusional parasitosis during treatment with pegylated interferon alpha-2b weekly and ribavirin. She complained of seeing parasites and th", "tokenized_content": [2, 24208, 10001, 4595, 17, 5751, 3, 1925, 2746, 3530, 43, 2723, 2670, 1923, 16891, 2475, 2409, 2311, 1956, 24208, 10001, 4595, 17, 5751, 9628, 1930, 23635, 18, 4693, 26199, 1927, 3]}, "items": [{"id": "p_566", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_567", "content": "neuroleptic malignant syndrome [SEP] Possible neuroleptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 3216, 20325, 17920, 6558, 4741, 2712, 1942, 8537, 2311, 1956, 21412, 15387, 1930, 14089, 5524, 13642, 10082, 3]}, "items": [{"id": "p_567", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_568", "content": "paroxetine [SEP] leptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam.", "tokenized_content": [2, 21412, 15387, 3, 16976, 1935, 6558, 4741, 2712, 1942, 8537, 2311, 1956, 21412, 15387, 1930, 14089, 5524, 13642, 10082, 18, 3]}, "items": [{"id": "p_568", "content": "Paroxetine [SEP] A serotonin uptake inhibitor that is effective in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21412, 15387, 3, 43, 11153, 5047, 4106, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_569", "content": "alprazolam [SEP] t syndrome related to concomitant treatment with paroxetine and alprazolam.", "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 62, 4741, 2712, 1942, 8537, 2311, 1956, 21412, 15387, 1930, 14089, 5524, 13642, 10082, 18, 3]}, "items": [{"id": "p_569", "content": "Alprazolam [SEP] A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC ", "score": 1, "type": null, "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 43, 5083, 10457, 14601, 18774, 2053, 3547, 1956, 2246, 1928, 18068, 3152, 1930, 28514, 17, 25810, 3153, 7728, 16, 1988, 1977, 15860, 1922, 1920, 2311, 1927, 21820, 3]}]}
{"query": {"id": "q_570", "content": "depressive symptoms [SEP] A 74-year-old man with depressive symptoms was admitted to a psychiatric hospital due to insomnia, loss of", "tokenized_content": [2, 7745, 3601, 3, 43, 5446, 17, 2476, 17, 4156, 2323, 1956, 7745, 3601, 1982, 9723, 1942, 43, 7652, 3461, 2810, 1942, 16882, 16, 3257, 1927, 3]}, "items": [{"id": "p_570", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_571", "content": "psychiatric [SEP] A 74-year-old man with depressive symptoms was admitted to a psychiatric hospital due to insomnia, loss of appetite, exhaustion, and agi", "tokenized_content": [2, 7652, 3, 43, 5446, 17, 2476, 17, 4156, 2323, 1956, 7745, 3601, 1982, 9723, 1942, 43, 7652, 3461, 2810, 1942, 16882, 16, 3257, 1927, 17990, 16, 19889, 16, 1930, 2260, 3]}, "items": [{"id": "p_571", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_572", "content": "insomnia [SEP] pressive symptoms was admitted to a psychiatric hospital due to insomnia, loss of appetite, exhaustion, and agitation. Medical treatment", "tokenized_content": [2, 16882, 3, 3477, 2320, 3601, 1982, 9723, 1942, 43, 7652, 3461, 2810, 1942, 16882, 16, 3257, 1927, 17990, 16, 19889, 16, 1930, 18389, 18, 3423, 2311, 3]}, "items": [{"id": "p_572", "content": "Sleep Initiation and Maintenance Disorders [SEP] Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in a", "score": 1, "type": null, "tokenized_content": [2, 5006, 6035, 1930, 6291, 4414, 3, 4414, 4378, 2007, 6159, 1927, 1920, 3682, 1942, 11051, 2014, 6698, 5006, 18, 2052, 2278, 4704, 1966, 43, 3065, 4770, 2014, 1922, 43, 3]}]}
{"query": {"id": "q_573", "content": "loss of appetite [SEP] ymptoms was admitted to a psychiatric hospital due to insomnia, loss of appetite, exhaustion, and agitation. Medical treatment was initiated at ", "tokenized_content": [2, 3257, 1927, 17990, 3, 23143, 3077, 1036, 1982, 9723, 1942, 43, 7652, 3461, 2810, 1942, 16882, 16, 3257, 1927, 17990, 16, 19889, 16, 1930, 18389, 18, 3423, 2311, 1982, 7796, 3]}, "items": [{"id": "p_573", "content": "Eating Disorders [SEP] A group of disorders characterized by physiological and psychological disturbances in appetite or food intake.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8979, 4414, 3, 43, 2210, 1927, 4414, 4378, 2007, 5005, 1930, 6674, 12654, 1922, 17990, 2014, 3959, 5240, 18, 3]}]}
{"query": {"id": "q_574", "content": "agitation [SEP] ric hospital due to insomnia, loss of appetite, exhaustion, and agitation. Medical treatment was initiated at a daily dose of 20 mg parox", "tokenized_content": [2, 18389, 3, 18091, 3461, 2810, 1942, 16882, 16, 3257, 1927, 17990, 16, 19889, 16, 1930, 18389, 18, 3423, 2311, 1982, 7796, 2019, 43, 4692, 3253, 1927, 2036, 2786, 21412, 3]}, "items": [{"id": "p_574", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_575", "content": "paroxetine [SEP] ation. Medical treatment was initiated at a daily dose of 20 mg paroxetine and 1.2 mg alprazolam. On the 10th day of paroxetine and alpraz", "tokenized_content": [2, 21412, 15387, 3, 2019, 2001, 18, 3423, 2311, 1982, 7796, 2019, 43, 4692, 3253, 1927, 2036, 2786, 21412, 15387, 1930, 21, 18, 22, 2786, 14089, 5524, 13642, 10082, 18, 1990, 3]}, "items": [{"id": "p_575", "content": "Paroxetine [SEP] A serotonin uptake inhibitor that is effective in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21412, 15387, 3, 43, 11153, 5047, 4106, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_576", "content": "alprazolam [SEP] nt was initiated at a daily dose of 20 mg paroxetine and 1.2 mg alprazolam. On the 10th day of paroxetine and alprazolam treatment, the pa", "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 5891, 1982, 7796, 2019, 43, 4692, 3253, 1927, 2036, 2786, 21412, 15387, 1930, 21, 18, 22, 2786, 14089, 5524, 13642, 10082, 18, 1990, 1920, 20005, 3]}, "items": [{"id": "p_576", "content": "Alprazolam [SEP] A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC ", "score": 1, "type": null, "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 43, 5083, 10457, 14601, 18774, 2053, 3547, 1956, 2246, 1928, 18068, 3152, 1930, 28514, 17, 25810, 3153, 7728, 16, 1988, 1977, 15860, 1922, 1920, 2311, 1927, 21820, 3]}]}
{"query": {"id": "q_577", "content": "psychomotor retardation [SEP] roxetine and alprazolam treatment, the patient exhibited marked psychomotor retardation, disorientation, and severe muscle rigidity with tremors. The p", "tokenized_content": [2, 26261, 16342, 3, 30044, 15387, 1930, 14089, 5524, 13642, 10082, 2311, 16, 1920, 2774, 5065, 4961, 26261, 16342, 16, 2054, 29292, 16, 1930, 4010, 3760, 20471, 1956, 18388, 1036, 18, 3]}, "items": [{"id": "p_577", "content": "Psychomotor Disorders [SEP] Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26261, 4414, 3, 6754, 1927, 4842, 2347, 1988, 2032, 2458, 1956, 6805, 1930, 2447, 17, 6805, 4328, 4414, 18, 3]}]}
{"query": {"id": "q_578", "content": "muscle rigidity [SEP] ited marked psychomotor retardation, disorientation, and severe muscle rigidity with tremors. The patient had a fever (38.2 degrees C), fluctua", "tokenized_content": [2, 3760, 20471, 3, 2176, 1919, 4961, 26261, 16342, 16, 2054, 29292, 16, 1930, 4010, 3760, 20471, 1956, 18388, 1036, 18, 1920, 2774, 2430, 43, 9087, 12, 3738, 18, 22, 6429, 3]}, "items": [{"id": "p_578", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_579", "content": "tremors [SEP] or retardation, disorientation, and severe muscle rigidity with tremors. The patient had a fever (38.2 degrees C), fluctuating blood pr", "tokenized_content": [2, 18388, 1036, 3, 2014, 16342, 16, 2054, 29292, 16, 1930, 4010, 3760, 20471, 1956, 18388, 1036, 18, 1920, 2774, 2430, 43, 9087, 12, 3738, 18, 22, 6429, 45, 13, 16, 3]}, "items": [{"id": "p_579", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_580", "content": "fever [SEP] ion, and severe muscle rigidity with tremors. The patient had a fever (38.2 degrees C), fluctuating blood pressure (between 165/90 an", "tokenized_content": [2, 9087, 3, 4755, 16, 1930, 4010, 3760, 20471, 1956, 18388, 1036, 18, 1920, 2774, 2430, 43, 9087, 12, 3738, 18, 22, 6429, 45, 13, 16, 26138, 2877, 3772, 12, 2192, 3]}, "items": [{"id": "p_580", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_581", "content": "extrapyramidal symptoms [SEP] blood pressure (between 165/90 and 130/70 mg mm Hg), and severe extrapyramidal symptoms. Laboratory tests showed an elevation of creatine phosphokinase", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 2877, 3772, 12, 2192, 14113, 19, 3865, 1930, 8761, 19, 3895, 2786, 2489, 7175, 13, 16, 1930, 4010, 21346, 3553, 25238, 1923, 3601, 18, 3]}, "items": [{"id": "p_581", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_582", "content": "creatine [SEP] xtrapyramidal symptoms. Laboratory tests showed an elevation of creatine phosphokinase (2218 IU/L), aspartate aminotransferase (134 IU/L", "tokenized_content": [2, 17784, 3, 23068, 5524, 18425, 25238, 1923, 3601, 18, 4542, 4026, 2594, 1925, 8644, 1927, 17784, 8078, 25545, 12, 17043, 1025, 11176, 19, 54, 13, 16, 12878, 15817, 12, 12724, 3]}, "items": [{"id": "p_582", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_583", "content": "aspartate [SEP] ests showed an elevation of creatine phosphokinase (2218 IU/L), aspartate aminotransferase (134 IU/L), alanine aminotransferase (78 IU/L)", "tokenized_content": [2, 12878, 3, 24638, 2594, 1925, 8644, 1927, 17784, 8078, 25545, 12, 17043, 1025, 11176, 19, 54, 13, 16, 12878, 15817, 12, 12724, 11176, 19, 54, 13, 16, 10504, 15817, 12, 3]}, "items": [{"id": "p_583", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_584", "content": "alanine [SEP] osphokinase (2218 IU/L), aspartate aminotransferase (134 IU/L), alanine aminotransferase (78 IU/L), and BUN (27.9 mg/ml) levels. The pa", "tokenized_content": [2, 10504, 3, 3125, 2102, 18655, 12, 17043, 1025, 11176, 19, 54, 13, 16, 12878, 15817, 12, 12724, 11176, 19, 54, 13, 16, 10504, 15817, 12, 5440, 11176, 19, 54, 13, 3]}, "items": [{"id": "p_584", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_585", "content": "bromocriptine [SEP] se (78 IU/L), and BUN (27.9 mg/ml) levels. The patient received bromocriptine and diazepam to treat his symptoms. 7 days later, the fever dis", "tokenized_content": [2, 21392, 4093, 2053, 3, 2058, 12, 5440, 11176, 19, 54, 13, 16, 1930, 20162, 12, 3225, 18, 29, 2786, 19, 2646, 13, 2428, 18, 1920, 2774, 4004, 21392, 4093, 2053, 3]}, "items": [{"id": "p_585", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_586", "content": "diazepam [SEP] BUN (27.9 mg/ml) levels. The patient received bromocriptine and diazepam to treat his symptoms. 7 days later, the fever disappeared and ", "tokenized_content": [2, 26079, 3, 20162, 12, 3225, 18, 29, 2786, 19, 2646, 13, 2428, 18, 1920, 2774, 4004, 21392, 4093, 2053, 1930, 26079, 1942, 2297, 4167, 3601, 18, 27, 3000, 3690, 16, 3]}, "items": [{"id": "p_586", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_587", "content": "neuroleptic malignant syndrome [SEP]  normalized (175 IU/L). This patient presented with symptoms of neuroleptic malignant syndrome (NMS), thus demonstrating that NMS-like symptoms can occur afte", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 5766, 12, 13919, 11176, 19, 54, 13, 18, 2052, 2774, 3549, 1956, 3601, 1927, 20325, 17920, 6558, 4741, 12, 25088, 13, 16, 2842, 7530, 1988, 3]}, "items": [{"id": "p_587", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_588", "content": "NMS [SEP] ient presented with symptoms of neuroleptic malignant syndrome (NMS), thus demonstrating that NMS-like symptoms can occur after com", "tokenized_content": [2, 25088, 3, 10116, 4905, 3549, 1956, 3601, 1927, 20325, 17920, 6558, 4741, 12, 25088, 13, 16, 2842, 7530, 1988, 25088, 17, 3189, 3601, 2112, 4704, 2256, 2008, 3]}, "items": [{"id": "p_588", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_589", "content": "depressive [SEP] A 74-year-old man with depressive symptoms was admitted to a psychiatric hospital due to insomnia", "tokenized_content": [2, 7745, 3, 43, 5446, 17, 2476, 17, 4156, 2323, 1956, 7745, 3601, 1982, 9723, 1942, 43, 7652, 3461, 2810, 1942, 16882, 3]}, "items": [{"id": "p_589", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_590", "content": "dehydration [SEP] ted in elderly depressive patients whose symptoms often include dehydration, agitation, malnutrition, and exhaustion. Careful therapeutic i", "tokenized_content": [2, 16585, 3, 26080, 1922, 7354, 7745, 2132, 6098, 3601, 3868, 3951, 16585, 16, 18389, 16, 16823, 16, 1930, 19889, 18, 8279, 4272, 51, 3]}, "items": [{"id": "p_590", "content": "Dehydration [SEP] The condition that results from excessive loss of water from a living organism.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16585, 3, 1920, 2625, 1988, 2274, 2037, 9122, 3257, 1927, 3224, 2037, 43, 5818, 9669, 18, 3]}]}
{"query": {"id": "q_591", "content": "malnutrition [SEP] e patients whose symptoms often include dehydration, agitation, malnutrition, and exhaustion. Careful therapeutic intervention is necessary ", "tokenized_content": [2, 16823, 3, 47, 2132, 6098, 3601, 3868, 3951, 16585, 16, 18389, 16, 16823, 16, 1930, 19889, 18, 8279, 4272, 3280, 1977, 4680, 3]}, "items": [{"id": "p_591", "content": "Malnutrition [SEP] An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16823, 3, 1925, 14093, 1007, 9369, 3642, 4306, 2037, 9406, 5240, 1927, 11312, 1942, 9572, 2791, 5005, 8853, 18, 3]}]}
{"query": {"id": "q_592", "content": "depression [SEP] s necessary in cases involving elderly patients who suffer from depression.", "tokenized_content": [2, 4621, 3, 61, 4680, 1922, 2919, 5884, 7354, 2132, 2746, 7416, 2037, 4621, 18, 3]}, "items": [{"id": "p_592", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_593", "content": "Pilocarpine [SEP] Pilocarpine seizures cause age-dependent impairment in auditory location di", "tokenized_content": [2, 7547, 7095, 12184, 3, 7547, 7095, 12184, 10060, 3936, 2632, 17, 3100, 6159, 1922, 8401, 5185, 2137, 3]}, "items": [{"id": "p_593", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_594", "content": "seizures [SEP] Pilocarpine seizures cause age-dependent impairment in auditory location discriminat", "tokenized_content": [2, 10060, 3, 7547, 7095, 12184, 10060, 3936, 2632, 17, 3100, 6159, 1922, 8401, 5185, 15964, 1926, 3]}, "items": [{"id": "p_594", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_595", "content": "impairment in auditory location discrimination [SEP] Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.", "tokenized_content": [2, 6159, 1922, 8401, 5185, 8638, 3, 7547, 7095, 12184, 10060, 3936, 2632, 17, 3100, 6159, 1922, 8401, 5185, 8638, 18, 3]}, "items": [{"id": "p_595", "content": "Auditory Perceptual Disorders [SEP] Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information ", "score": 1, "type": null, "tokenized_content": [2, 8401, 12365, 4414, 3, 5815, 2014, 5878, 4328, 4414, 1927, 8401, 6262, 4378, 2007, 43, 3028, 3682, 1942, 18016, 2988, 3]}]}
{"query": {"id": "q_596", "content": "status epilepticus [SEP] Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-", "tokenized_content": [2, 3642, 16304, 1957, 3, 3069, 2746, 2162, 3642, 16304, 1957, 2162, 4798, 2014, 6221, 21763, 10060, 1988, 2278, 1998, 3308, 17, 3]}, "items": [{"id": "p_596", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_597", "content": "seizures [SEP] ho have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in", "tokenized_content": [2, 10060, 3, 6673, 2162, 3642, 16304, 1957, 2162, 4798, 2014, 6221, 21763, 10060, 1988, 2278, 1998, 3308, 17, 13281, 1930, 2278, 3936, 3308, 17, 2815, 2840, 1922, 3]}, "items": [{"id": "p_597", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_598", "content": "deficits in auditory discrimination [SEP] ain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination met", "tokenized_content": [2, 7961, 1922, 8401, 8638, 3, 9798, 1022, 1930, 3379, 18, 1920, 5064, 1942, 2154, 3642, 16304, 1957, 5092, 7961, 1922, 8401, 8638, 1977, 5435, 18, 43, 4613, 4036, 8401, 5185, 3]}, "items": [{"id": "p_598", "content": "Auditory Perceptual Disorders [SEP] Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information ", "score": 1, "type": null, "tokenized_content": [2, 8401, 12365, 4414, 3, 5815, 2014, 5878, 4328, 4414, 1927, 8401, 6262, 4378, 2007, 43, 3028, 3682, 1942, 18016, 2988, 3]}]}
{"query": {"id": "q_599", "content": "pilocarpine [SEP] ed with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilept", "tokenized_content": [2, 7547, 7095, 12184, 3, 3347, 1956, 5977, 1990, 9992, 3007, 12, 58, 13, 2036, 16, 2014, 43, 4772, 6325, 2031, 3253, 1927, 7547, 7095, 12184, 1990, 29019, 2014, 9068, 1015, 3]}, "items": [{"id": "p_599", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_600", "content": "Pilocarpine [SEP]  day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at", "tokenized_content": [2, 7547, 7095, 12184, 3, 3007, 12, 58, 13, 2036, 16, 2014, 43, 4772, 6325, 2031, 3253, 1927, 7547, 7095, 12184, 1990, 29019, 2014, 9068, 1015, 18, 7547, 7095, 12184, 1990, 3]}, "items": [{"id": "p_600", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_601", "content": "Status epilepticus [SEP] e sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or so", "tokenized_content": [2, 3642, 16304, 1957, 3, 47, 8454, 17, 4585, 5185, 8638, 1982, 11224, 5761, 18, 3642, 16304, 1957, 12, 9068, 1015, 13, 3615, 6617, 1942, 13174, 3108, 8454, 17, 4585, 5185, 3]}, "items": [{"id": "p_601", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_602", "content": "impairment in auditory discrimination [SEP] s. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory loc", "tokenized_content": [2, 6159, 1922, 8401, 8638, 3, 61, 18, 3642, 16304, 1957, 1922, 3067, 5092, 1925, 2632, 17, 3100, 16, 2815, 17, 2576, 6159, 1922, 8401, 8638, 18, 2052, 6159, 2278, 5895, 3]}, "items": [{"id": "p_602", "content": "Auditory Perceptual Disorders [SEP] Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information ", "score": 1, "type": null, "tokenized_content": [2, 8401, 12365, 4414, 3, 5815, 2014, 5878, 4328, 4414, 1927, 8401, 6262, 4378, 2007, 43, 3028, 3682, 1942, 18016, 2988, 3]}]}
{"query": {"id": "q_603", "content": "impaired auditory location discrimination [SEP] ditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans.", "tokenized_content": [2, 5761, 8401, 5185, 8638, 3, 2137, 27708, 8638, 18, 2052, 6159, 2278, 5895, 2340, 3936, 1927, 5761, 8401, 5185, 8638, 1922, 5209, 18, 3]}, "items": [{"id": "p_603", "content": "Auditory Perceptual Disorders [SEP] Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information ", "score": 1, "type": null, "tokenized_content": [2, 8401, 12365, 4414, 3, 5815, 2014, 5878, 4328, 4414, 1927, 8401, 6262, 4378, 2007, 43, 3028, 3682, 1942, 18016, 2988, 3]}]}
{"query": {"id": "q_604", "content": "cyclooxygenase inhibitors [SEP] Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?", "tokenized_content": [2, 21271, 4472, 3, 5321, 2565, 1956, 21271, 4472, 30, 3335, 4915, 1956, 7311, 2487, 2886, 35, 3]}, "items": [{"id": "p_604", "content": "Cyclooxygenase Inhibitors [SEP] Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-en", "score": 1, "type": null, "tokenized_content": [2, 21271, 4472, 3, 4300, 2014, 4820, 1988, 14003, 1956, 21271, 12, 15900, 17, 16239, 2116, 6211, 8921, 1036, 13, 1930, 6113, 4625, 2496, 4510, 17, 2066, 3]}]}
{"query": {"id": "q_605", "content": "myocardial infarction [SEP] rials and observational studies have shown an increased risk of myocardial infarction, stroke, hypertension and heart failure during treatment with c", "tokenized_content": [2, 6497, 8358, 3, 27777, 4668, 1930, 9688, 2351, 2162, 2522, 1925, 2502, 2565, 1927, 6497, 8358, 16, 5235, 16, 5579, 1930, 4003, 4574, 2409, 2311, 1956, 45, 3]}, "items": [{"id": "p_605", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_606", "content": "stroke [SEP]  studies have shown an increased risk of myocardial infarction, stroke, hypertension and heart failure during treatment with cyclooxyg", "tokenized_content": [2, 5235, 3, 2351, 2162, 2522, 1925, 2502, 2565, 1927, 6497, 8358, 16, 5235, 16, 5579, 1930, 4003, 4574, 2409, 2311, 1956, 17009, 7221, 1029, 3]}, "items": [{"id": "p_606", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_607", "content": "hypertension [SEP]  have shown an increased risk of myocardial infarction, stroke, hypertension and heart failure during treatment with cyclooxygenase inhibito", "tokenized_content": [2, 5579, 3, 2162, 2522, 1925, 2502, 2565, 1927, 6497, 8358, 16, 5235, 16, 5579, 1930, 4003, 4574, 2409, 2311, 1956, 21271, 2875, 1037, 3]}, "items": [{"id": "p_607", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_608", "content": "heart failure [SEP] creased risk of myocardial infarction, stroke, hypertension and heart failure during treatment with cyclooxygenase inhibitors. Adverse cardio", "tokenized_content": [2, 4003, 4574, 3, 3478, 2148, 2565, 1927, 6497, 8358, 16, 5235, 16, 5579, 1930, 4003, 4574, 2409, 2311, 1956, 21271, 4472, 18, 5246, 21129, 3]}, "items": [{"id": "p_608", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_609", "content": "cyclooxygenase inhibitors [SEP] n, stroke, hypertension and heart failure during treatment with cyclooxygenase inhibitors. Adverse cardiovascular effects occurred mainly, but not exclus", "tokenized_content": [2, 21271, 4472, 3, 56, 16, 5235, 16, 5579, 1930, 4003, 4574, 2409, 2311, 1956, 21271, 4472, 18, 5246, 5321, 2564, 4807, 4994, 16, 2308, 2084, 3698, 1957, 3]}, "items": [{"id": "p_609", "content": "Cyclooxygenase Inhibitors [SEP] Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-en", "score": 1, "type": null, "tokenized_content": [2, 21271, 4472, 3, 4300, 2014, 4820, 1988, 14003, 1956, 21271, 12, 15900, 17, 16239, 2116, 6211, 8921, 1036, 13, 1930, 6113, 4625, 2496, 4510, 17, 2066, 3]}]}
{"query": {"id": "q_610", "content": "Cyclooxygenase inhibitors [SEP] but not exclusively, in patients with concomitant risk factors. Cyclooxygenase inhibitors cause complex changes in renal, vascular and cardiac prostanoid", "tokenized_content": [2, 21271, 4472, 3, 2308, 2084, 9326, 16, 1922, 2132, 1956, 8537, 2565, 2790, 18, 21271, 4472, 3936, 2796, 2840, 1922, 4604, 16, 4541, 1930, 4435, 4876, 9286, 1960, 3]}, "items": [{"id": "p_610", "content": "Cyclooxygenase Inhibitors [SEP] Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-en", "score": 1, "type": null, "tokenized_content": [2, 21271, 4472, 3, 4300, 2014, 4820, 1988, 14003, 1956, 21271, 12, 15900, 17, 16239, 2116, 6211, 8921, 1036, 13, 1930, 6113, 4625, 2496, 4510, 17, 2066, 3]}]}
{"query": {"id": "q_611", "content": "prostaglandin [SEP] etic parameters or inhibitory potency and may be contributed by prostaglandin-independent effects. Diagnostic markers such as N-terminal pro ", "tokenized_content": [2, 15900, 3, 8096, 1030, 3673, 2014, 5431, 10397, 1930, 2278, 1998, 6505, 2007, 15900, 17, 3484, 2564, 18, 4785, 4432, 2427, 1966, 56, 17, 4262, 1965, 3]}, "items": [{"id": "p_611", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_612", "content": "N-terminal pro brain natriuretic peptide [SEP] y prostaglandin-independent effects. Diagnostic markers such as N-terminal pro brain natriuretic peptide (NT-proBNP) or high-sensitive C-reactive protein might help in ", "tokenized_content": [2, 56, 17, 4262, 1965, 3068, 20434, 4207, 3, 67, 15900, 17, 3484, 2564, 18, 4785, 4432, 2427, 1966, 56, 17, 4262, 1965, 3068, 20434, 4207, 12, 5891, 17, 23312, 13, 3]}, "items": [{"id": "p_612", "content": "pro-brain natriuretic peptide (1-76) [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1965, 17, 3068, 20434, 4207, 12, 21, 17, 5439, 13, 3, 3]}]}
{"query": {"id": "q_613", "content": "NT-proBNP [SEP] ostic markers such as N-terminal pro brain natriuretic peptide (NT-proBNP) or high-sensitive C-reactive protein might help in the early i", "tokenized_content": [2, 5891, 17, 23312, 3, 17677, 1935, 4432, 2427, 1966, 56, 17, 4262, 1965, 3068, 20434, 4207, 12, 5891, 17, 23312, 13, 2014, 2149, 17, 4532, 45, 17, 6079, 2213, 3284, 3]}, "items": [{"id": "p_613", "content": "pro-brain natriuretic peptide (1-76) [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1965, 17, 3068, 20434, 4207, 12, 21, 17, 5439, 13, 3, 3]}]}
{"query": {"id": "q_614", "content": "cardiovascular toxicity [SEP] on of patients at risk, thus avoiding the occurrence of serious cardiovascular toxicity.", "tokenized_content": [2, 5321, 5532, 3, 1990, 1927, 2132, 2019, 2565, 16, 2842, 13910, 1920, 6564, 1927, 7433, 5321, 5532, 18, 3]}, "items": [{"id": "p_614", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_615", "content": "decreased renal function [SEP] Predictors of decreased renal function in patients with heart failure during angiotensin-converting en", "tokenized_content": [2, 3261, 4604, 2347, 3, 7450, 1927, 3261, 4604, 2347, 1922, 2132, 1956, 4003, 4574, 2409, 10814, 17, 15025, 2066, 3]}, "items": [{"id": "p_615", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_616", "content": "heart failure [SEP] Predictors of decreased renal function in patients with heart failure during angiotensin-converting enzyme inhibitor therapy: results", "tokenized_content": [2, 4003, 4574, 3, 7450, 1927, 3261, 4604, 2347, 1922, 2132, 1956, 4003, 4574, 2409, 10814, 17, 15025, 4113, 4106, 3181, 30, 2274, 3]}, "items": [{"id": "p_616", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_617", "content": "angiotensin [SEP]  decreased renal function in patients with heart failure during angiotensin-converting enzyme inhibitor therapy: results from the studies o", "tokenized_content": [2, 10814, 3, 3261, 4604, 2347, 1922, 2132, 1956, 4003, 4574, 2409, 10814, 17, 15025, 4113, 4106, 3181, 30, 2274, 2037, 1920, 2351, 57, 3]}, "items": [{"id": "p_617", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_618", "content": "left ventricular dysfunction [SEP] onverting enzyme inhibitor therapy: results from the studies of left ventricular dysfunction (SOLVD)", "tokenized_content": [2, 3506, 6493, 5273, 3, 1990, 22212, 1941, 4113, 4106, 3181, 30, 2274, 2037, 1920, 2351, 1927, 3506, 6493, 5273, 12, 12581, 1007, 13, 3]}, "items": [{"id": "p_618", "content": "Ventricular Dysfunction, Left [SEP] A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; M", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 16, 3506, 3, 43, 2625, 1922, 2154, 1920, 3506, 11887, 1927, 1920, 4003, 1982, 9346, 5761, 18, 2052, 2625, 5394, 5029, 1942, 4003, 4574, 31, 55, 3]}]}
{"query": {"id": "q_619", "content": "angiotensin [SEP] BACKGROUND: Although angiotensin-converting enzyme inhibitor therapy reduces mortality rates in ", "tokenized_content": [2, 10814, 3, 3872, 30, 2876, 10814, 17, 15025, 4113, 4106, 3181, 7268, 3885, 3389, 1922, 3]}, "items": [{"id": "p_619", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_620", "content": "congestive heart failure [SEP] zyme inhibitor therapy reduces mortality rates in patients with congestive heart failure (CHF), it may also cause decreased renal function. Little infor", "tokenized_content": [2, 20180, 4003, 4574, 3, 15856, 1021, 4106, 3181, 7268, 3885, 3389, 1922, 2132, 1956, 20180, 4003, 4574, 12, 18307, 13, 16, 2176, 2278, 2222, 3936, 3261, 4604, 2347, 18, 5082, 3]}, "items": [{"id": "p_620", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_621", "content": "CHF [SEP] uces mortality rates in patients with congestive heart failure (CHF), it may also cause decreased renal function. Little informatio", "tokenized_content": [2, 18307, 3, 8577, 1918, 3885, 3389, 1922, 2132, 1956, 20180, 4003, 4574, 12, 18307, 13, 16, 2176, 2278, 2222, 3936, 3261, 4604, 2347, 18, 5082, 2780, 1968, 1037, 3]}, "items": [{"id": "p_621", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_622", "content": "decreased renal function [SEP] patients with congestive heart failure (CHF), it may also cause decreased renal function. Little information is available to predict which patients are ", "tokenized_content": [2, 3261, 4604, 2347, 3, 2132, 1956, 20180, 4003, 4574, 12, 18307, 13, 16, 2176, 2278, 2222, 3936, 3261, 4604, 2347, 18, 5082, 2988, 1977, 3322, 1942, 5660, 2154, 2132, 2032, 3]}, "items": [{"id": "p_622", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_623", "content": "reduction in renal function [SEP] ication. OBJECTIVE: To quantify specific clinical predictors of reduction in renal function in patients with CHF who are prescribed angiotensin-converting ", "tokenized_content": [2, 3378, 1922, 4604, 2347, 3, 14784, 1929, 18, 4470, 30, 1942, 8730, 2487, 2535, 7450, 1927, 3378, 1922, 4604, 2347, 1922, 2132, 1956, 18307, 2746, 2032, 9975, 10814, 17, 15025, 3]}, "items": [{"id": "p_623", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_624", "content": "Left Ventricular Dysfunction [SEP] inhibitor therapy. METHOD: We analyzed data from the Studies of Left Ventricular Dysfunction (SOLVD), a randomized, double-blind, placebo-controlled trial o", "tokenized_content": [2, 3506, 6493, 5273, 3, 4106, 3181, 18, 2417, 30, 2038, 3265, 2230, 2037, 1920, 2351, 1927, 3506, 6493, 5273, 12, 12581, 1007, 13, 16, 43, 5542, 16, 4825, 17, 7109, 3]}, "items": [{"id": "p_624", "content": "Ventricular Dysfunction, Left [SEP] A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; M", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 16, 3506, 3, 43, 2625, 1922, 2154, 1920, 3506, 11887, 1927, 1920, 4003, 1982, 9346, 5761, 18, 2052, 2625, 5394, 5029, 1942, 4003, 4574, 31, 55, 3]}]}
{"query": {"id": "q_625", "content": "enalapril [SEP] SOLVD), a randomized, double-blind, placebo-controlled trial of enalapril for the treatment of CHF. There were 3379 patients randomly ass", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 12581, 1007, 13, 16, 43, 5542, 16, 4825, 17, 7109, 16, 5936, 17, 4642, 3046, 1927, 2066, 8056, 2047, 1970, 1958, 1920, 2311, 1927, 18307, 3]}, "items": [{"id": "p_625", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_626", "content": "Decreased renal function [SEP] randomly assigned to placebo with a mean follow-up of 967 days. Decreased renal function was defined as a rise in serum creatinine >/=0.5 mg/dL (44 micr", "tokenized_content": [2, 3261, 4604, 2347, 3, 6266, 6304, 1942, 5936, 1956, 43, 2667, 2396, 17, 2353, 1927, 4746, 1027, 3000, 18, 3261, 4604, 2347, 1982, 3608, 1966, 43, 7164, 1922, 3256, 9374, 3]}, "items": [{"id": "p_626", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_627", "content": "creatinine [SEP] 7 days. Decreased renal function was defined as a rise in serum creatinine >/=0.5 mg/dL (44 micromol/L) from baseline. We used time-to-eve", "tokenized_content": [2, 9374, 3, 27, 3000, 18, 3261, 4604, 2347, 1982, 3608, 1966, 43, 7164, 1922, 3256, 9374, 34, 19, 33, 20, 18, 25, 2786, 19, 5268, 12, 4044, 25385, 19, 54, 3]}, "items": [{"id": "p_627", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_628", "content": "hypertension [SEP] reatinine, low systolic blood pressure (<100 mm Hg), history of hypertension, diabetes, and use of antiplatelet, diuretic, and beta-blocker ", "tokenized_content": [2, 5579, 3, 1964, 3248, 2053, 16, 2330, 8541, 2877, 3772, 12, 32, 2813, 2489, 7175, 13, 16, 4403, 1927, 5579, 16, 4032, 16, 1930, 2485, 1927, 21348, 16, 26829, 16, 3]}, "items": [{"id": "p_628", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_629", "content": "diabetes [SEP]  systolic blood pressure (<100 mm Hg), history of hypertension, diabetes, and use of antiplatelet, diuretic, and beta-blocker therapy. R", "tokenized_content": [2, 4032, 3, 8541, 2877, 3772, 12, 32, 2813, 2489, 7175, 13, 16, 4403, 1927, 5579, 16, 4032, 16, 1930, 2485, 1927, 21348, 16, 26829, 16, 1930, 4666, 17, 14580, 3181, 3]}, "items": [{"id": "p_629", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_630", "content": "diuretic [SEP] g), history of hypertension, diabetes, and use of antiplatelet, diuretic, and beta-blocker therapy. RESULTS: Patients randomly assigned ", "tokenized_content": [2, 26829, 3, 49, 13, 16, 4403, 1927, 5579, 16, 4032, 16, 1930, 2485, 1927, 21348, 16, 26829, 16, 1930, 4666, 17, 14580, 3181, 18, 2274, 30, 2132, 6266, 6304, 3]}, "items": [{"id": "p_630", "content": "Diuretics [SEP] Agents that promote the excretion of urine through their effects on kidney function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25505, 3, 4820, 1988, 5527, 1920, 11093, 1927, 6960, 2596, 2310, 2564, 1990, 5245, 2347, 18, 3]}]}
{"query": {"id": "q_631", "content": "Diuretic [SEP]  1.32-1.52 with enalapril; placebo: RR 1.18, 95% CI 1.12-1.25). Diuretic therapy was likewise associated with a greater risk of decrease", "tokenized_content": [2, 26829, 3, 21, 18, 3323, 17, 21, 18, 4764, 1956, 2066, 8056, 2047, 1970, 31, 5936, 30, 5162, 21, 18, 2654, 16, 3002, 9, 3371, 21, 18, 2369, 17, 21, 3]}, "items": [{"id": "p_631", "content": "Diuretics [SEP] Agents that promote the excretion of urine through their effects on kidney function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25505, 3, 4820, 1988, 5527, 1920, 11093, 1927, 6960, 2596, 2310, 2564, 1990, 5245, 2347, 18, 3]}]}
{"query": {"id": "q_632", "content": "renal impairment [SEP] 6, 95% CI 1.57-2.44) in patients with diabetes. A lower risk of renal impairment was seen in both groups with beta-blocker therapy (RR 0.70, 95%", "tokenized_content": [2, 4604, 6159, 3, 26, 16, 3002, 9, 3371, 21, 18, 4786, 17, 22, 18, 4044, 13, 1922, 2132, 1956, 4032, 18, 43, 2826, 2565, 1927, 4604, 6159, 1982, 3945, 1922, 3]}, "items": [{"id": "p_632", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_633", "content": "Enalapril [SEP] ion (RR 0.93 per 5% increment, 95% CI 0.91-0. 96). CONCLUSIONS: Enalapril use caused a 33% increase in the risk of decreased renal functi", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 4755, 12, 5162, 20, 18, 6156, 2079, 25, 9, 16328, 16, 3002, 9, 3371, 20, 18, 6550, 17, 20, 18, 4746, 13, 18, 4355, 30, 3]}, "items": [{"id": "p_633", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_634", "content": "Diabetes [SEP] ts with CHF. Diuretic use and advanced age increased this risk. Diabetes was associated with an increased risk of renal impairment in al", "tokenized_content": [2, 4032, 3, 4894, 1956, 18307, 18, 26829, 2485, 1930, 5570, 2632, 2502, 2052, 2565, 18, 4032, 1982, 2458, 1956, 1925, 2502, 2565, 1927, 4604, 6159, 1922, 1969, 3]}, "items": [{"id": "p_634", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_635", "content": "Pemoline [SEP] Pemoline induced acute choreoathetosis: case report and review of the li", "tokenized_content": [2, 17526, 8419, 3, 17526, 8419, 2719, 3939, 11418, 1021, 6952, 20536, 4575, 8362, 30, 3087, 3809, 1930, 3043, 1927, 1920, 2336, 3]}, "items": [{"id": "p_635", "content": "Pemoline [SEP] A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17526, 8419, 3, 43, 4101, 7580, 2433, 24252, 2251, 1922, 8656, 1930, 7745, 4376, 1930, 1942, 2297, 4194, 24590, 2002, 4414, 1922, 3069, 18, 3]}]}
{"query": {"id": "q_636", "content": "Pemoline [SEP] BACKGROUND: Pemoline is an oxazolidine derivative that is structurally different fro", "tokenized_content": [2, 17526, 8419, 3, 3872, 30, 17526, 8419, 1977, 1925, 28905, 13642, 12191, 27099, 10533, 1988, 1977, 12171, 2413, 7542, 3]}, "items": [{"id": "p_636", "content": "Pemoline [SEP] A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17526, 8419, 3, 43, 4101, 7580, 2433, 24252, 2251, 1922, 8656, 1930, 7745, 4376, 1930, 1942, 2297, 4194, 24590, 2002, 4414, 1922, 3069, 18, 3]}]}
{"query": {"id": "q_637", "content": "oxazolidine [SEP] BACKGROUND: Pemoline is an oxazolidine derivative that is structurally different from amphetamines and", "tokenized_content": [2, 28905, 13642, 12191, 27099, 3, 3872, 30, 17526, 8419, 1977, 1925, 28905, 13642, 12191, 27099, 10533, 1988, 1977, 12171, 2413, 2037, 19057, 1036, 1930, 3]}, "items": [{"id": "p_637", "content": "oxazolidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28905, 13642, 12191, 27099, 3, 3]}]}
{"query": {"id": "q_638", "content": "amphetamines [SEP] s an oxazolidine derivative that is structurally different from amphetamines and used in the treatment of attention deficit disorder. Pemoli", "tokenized_content": [2, 19057, 1036, 3, 61, 1925, 28905, 13642, 12191, 27099, 10533, 1988, 1977, 12171, 2413, 2037, 19057, 1036, 1930, 2251, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 18, 17526, 8436, 3]}, "items": [{"id": "p_638", "content": "Amphetamines [SEP] Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vaso", "score": 1, "type": null, "tokenized_content": [2, 19057, 1036, 3, 13204, 2014, 8383, 1927, 19057, 18, 3086, 2032, 26638, 1947, 21870, 1036, 1930, 4101, 7580, 2433, 24052, 1036, 7538, 8392, 16, 22866, 3]}]}
{"query": {"id": "q_639", "content": "attention deficit disorder [SEP] urally different from amphetamines and used in the treatment of attention deficit disorder. Pemoline has not been commonly associated in the literature as", "tokenized_content": [2, 4976, 10506, 4770, 3, 3674, 2169, 2413, 2037, 19057, 1036, 1930, 2251, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 18, 17526, 8419, 2258, 2084, 2252, 5384, 2458, 1922, 1920, 4431, 3]}, "items": [{"id": "p_639", "content": "Attention Deficit Disorder with Hyperactivity [SEP] A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattent", "score": 1, "type": null, "tokenized_content": [2, 4976, 10506, 4770, 1956, 15534, 3, 43, 3379, 4770, 14391, 1922, 7238, 1922, 2154, 1920, 4415, 4075, 2032, 6879, 1927, 23130, 13770, 27351, 1939, 3]}]}
{"query": {"id": "q_640", "content": "movement disorders [SEP]  been commonly associated in the literature as a cause of acute movement disorders. The following case describes two children acutely poisoned wit", "tokenized_content": [2, 5829, 4414, 3, 2252, 5384, 2458, 1922, 1920, 4431, 1966, 43, 3936, 1927, 3939, 5829, 4414, 18, 1920, 2894, 3087, 9845, 2288, 3069, 18141, 15501, 1919, 16086, 3]}, "items": [{"id": "p_640", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_641", "content": "pemoline [SEP] The following case describes two children acutely poisoned with pemoline who experienced profound choreoathetosis. CASE REPORT: Two, 3-y", "tokenized_content": [2, 17526, 8419, 3, 1920, 2894, 3087, 9845, 2288, 3069, 18141, 15501, 1919, 1956, 17526, 8419, 2746, 6090, 11098, 11418, 1021, 6952, 20536, 4575, 8362, 18, 3087, 3809, 30, 2288, 16, 3]}, "items": [{"id": "p_641", "content": "Pemoline [SEP] A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17526, 8419, 3, 43, 4101, 7580, 2433, 24252, 2251, 1922, 8656, 1930, 7745, 4376, 1930, 1942, 2297, 4194, 24590, 2002, 4414, 1922, 3069, 18, 3]}]}
{"query": {"id": "q_642", "content": "methylphenidate [SEP] nificant for attention deficit disorder previously treated with methylphenidate without success. This was their first day of pemoline therapy. ", "tokenized_content": [2, 4963, 17616, 21550, 3, 17719, 13611, 1031, 1958, 4976, 10506, 4770, 3024, 2868, 1956, 4963, 17616, 21550, 2979, 3811, 18, 2052, 1982, 2310, 2561, 3007, 1927, 17526, 8419, 3181, 18, 3]}, "items": [{"id": "p_642", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_643", "content": "benzodiazepines [SEP]  gastrointestinal decontamination and high doses of intravenous benzodiazepines in an attempt to control the choreoathetoid movements. Despite ", "tokenized_content": [2, 26555, 3, 8375, 2344, 4202, 8732, 1930, 2149, 5312, 1927, 7307, 26555, 1922, 1925, 9289, 1942, 2285, 1920, 11418, 1021, 6952, 20536, 4575, 1960, 8264, 18, 4281, 3]}, "items": [{"id": "p_643", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_644", "content": "movement disorder [SEP]  been commonly associated in the literature as a cause of acute movement disorders. The following case describes two children acutely poisoned wi", "tokenized_content": [2, 5829, 4770, 3, 2252, 5384, 2458, 1922, 1920, 4431, 1966, 43, 3936, 1927, 3939, 5829, 4414, 18, 1920, 2894, 3087, 9845, 2288, 3069, 18141, 15501, 1919, 11980, 3]}, "items": [{"id": "p_644", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_645", "content": "overdose [SEP] ents should be considered in patients presenting after pemoline overdose.", "tokenized_content": [2, 21090, 3, 8496, 1036, 3066, 1998, 3311, 1922, 2132, 8326, 2256, 17526, 8419, 21090, 18, 3]}, "items": [{"id": "p_645", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_646", "content": "mesna [SEP] Continuous subcutaneous administration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 4438, 2175, 3, 4798, 8634, 4183, 1927, 4438, 2175, 1942, 4625, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_646", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_647", "content": "ifosfamide [SEP] Continuous subcutaneous administration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 4798, 8634, 4183, 1927, 4438, 2175, 1942, 4625, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_647", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_648", "content": "hemorrhagic [SEP] cutaneous administration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 16052, 3, 11276, 4183, 1927, 4438, 2175, 1942, 4625, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_648", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_649", "content": "cystitis [SEP] ministration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 9446, 3678, 3, 9696, 2156, 5524, 1929, 1927, 4438, 2175, 1942, 4625, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_649", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_650", "content": "Hemorrhagic [SEP] Hemorrhagic cystitis is a major potential toxicity of ifosfamide that can b", "tokenized_content": [2, 16052, 3, 16052, 9446, 3678, 1977, 43, 3044, 2889, 5532, 1927, 2647, 1951, 6016, 16408, 1021, 1988, 2112, 44, 3]}, "items": [{"id": "p_650", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_651", "content": "cystitis [SEP] Hemorrhagic cystitis is a major potential toxicity of ifosfamide that can be prevent", "tokenized_content": [2, 9446, 3678, 3, 16052, 9446, 3678, 1977, 43, 3044, 2889, 5532, 1927, 2647, 1951, 6016, 16408, 1021, 1988, 2112, 1998, 4625, 3]}, "items": [{"id": "p_651", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_652", "content": "toxicity [SEP] Hemorrhagic cystitis is a major potential toxicity of ifosfamide that can be prevented by administering mesna alon", "tokenized_content": [2, 5532, 3, 16052, 9446, 3678, 1977, 43, 3044, 2889, 5532, 1927, 2647, 1951, 6016, 16408, 1021, 1988, 2112, 1998, 8715, 2007, 20921, 4438, 2175, 1969, 1916, 3]}, "items": [{"id": "p_652", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_653", "content": "ifosfamide [SEP] Hemorrhagic cystitis is a major potential toxicity of ifosfamide that can be prevented by administering mesna along with the cyt", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 16052, 9446, 3678, 1977, 43, 3044, 2889, 5532, 1927, 2647, 1951, 6016, 16408, 1021, 1988, 2112, 1998, 8715, 2007, 20921, 4438, 2175, 4231, 1956, 3]}, "items": [{"id": "p_653", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_654", "content": "mesna [SEP] l toxicity of ifosfamide that can be prevented by administering mesna along with the cytotoxic agent. Mesna is generally administered", "tokenized_content": [2, 4438, 2175, 3, 54, 5532, 1927, 2647, 1951, 6016, 16408, 1021, 1988, 2112, 1998, 8715, 2007, 20921, 4438, 2175, 4231, 1956, 1920, 8377, 5899, 18, 4438, 2175, 1977, 4933, 5254, 3]}, "items": [{"id": "p_654", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_655", "content": "Mesna [SEP] revented by administering mesna along with the cytotoxic agent. Mesna is generally administered by the intravenous route, although ex", "tokenized_content": [2, 4438, 2175, 3, 27720, 2013, 2007, 20921, 4438, 2175, 4231, 1956, 1920, 8377, 5899, 18, 4438, 2175, 1977, 4933, 5254, 2007, 1920, 7307, 9629, 16, 2876, 1975, 3]}, "items": [{"id": "p_655", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_656", "content": "emesis [SEP] ent taking oral mesna who experiences severe ifosfamide-induced emesis and is unable to absorb the drug. Limited clinical experience w", "tokenized_content": [2, 2391, 2600, 3, 8496, 6303, 4726, 4438, 2175, 2746, 7651, 4010, 2647, 1951, 6016, 16408, 1021, 17, 2719, 2391, 2600, 1930, 1977, 8082, 1942, 7322, 1920, 2838, 18, 3892, 2535, 3]}, "items": [{"id": "p_656", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_657", "content": "hyperammonemia [SEP] Modification of drug action by hyperammonemia.", "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 6295, 1927, 2838, 4615, 2007, 4194, 2595, 2290, 6026, 18, 3]}, "items": [{"id": "p_657", "content": "Hyperammonemia [SEP] Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 4664, 2237, 1927, 14880, 1922, 1920, 2877, 18, 2176, 1977, 43, 2105, 1927, 9785, 19480, 1927, 3835, 4576, 2014, 14880, 1942, 10505, 18, 3]}]}
{"query": {"id": "q_658", "content": "ammonium acetate [SEP] Pretreatment with ammonium acetate (NH4Ac) (6 mmol/kg s.c.) approximately doubled the time morphin", "tokenized_content": [2, 11944, 7959, 3, 9111, 1956, 11944, 7959, 12, 14945, 1948, 13, 12, 26, 6397, 19, 3621, 61, 18, 45, 18, 13, 3993, 20875, 1920, 2367, 3901, 1921, 3]}, "items": [{"id": "p_658", "content": "ammonium acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11944, 7959, 3, 3]}]}
{"query": {"id": "q_659", "content": "NH4Ac [SEP] Pretreatment with ammonium acetate (NH4Ac) (6 mmol/kg s.c.) approximately doubled the time morphine-treat", "tokenized_content": [2, 14945, 1948, 3, 9111, 1956, 11944, 7959, 12, 14945, 1948, 13, 12, 26, 6397, 19, 3621, 61, 18, 45, 18, 13, 3993, 20875, 1920, 2367, 11553, 17, 2297, 3]}, "items": [{"id": "p_659", "content": "ammonium acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11944, 7959, 3, 3]}]}
{"query": {"id": "q_660", "content": "morphine [SEP] acetate (NH4Ac) (6 mmol/kg s.c.) approximately doubled the time morphine-treated mice remained on a hot surface and similarly increased ", "tokenized_content": [2, 11553, 3, 7959, 12, 14945, 1948, 13, 12, 26, 6397, 19, 3621, 61, 18, 45, 18, 13, 3993, 20875, 1920, 2367, 11553, 17, 2868, 2518, 5410, 1990, 43, 9529, 3154, 3]}, "items": [{"id": "p_660", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_661", "content": "incoordination [SEP] mice remained on a hot surface and similarly increased muscular incoordination by diazepam, but NH4Ac treatment alone had no effect. Thus, hyp", "tokenized_content": [2, 2043, 8883, 22816, 1943, 3, 2518, 5410, 1990, 43, 9529, 3154, 1930, 4852, 2502, 12330, 2043, 8883, 22816, 1943, 2007, 26079, 16, 2308, 14945, 1948, 2311, 4298, 2430, 2239, 2495, 3]}, "items": [{"id": "p_661", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_662", "content": "diazepam [SEP]  hot surface and similarly increased muscular incoordination by diazepam, but NH4Ac treatment alone had no effect. Thus, hyperammonemia ", "tokenized_content": [2, 26079, 3, 9529, 3154, 1930, 4852, 2502, 12330, 2043, 8883, 22816, 1943, 2007, 26079, 16, 2308, 14945, 1948, 2311, 4298, 2430, 2239, 2495, 18, 2842, 16, 4194, 2595, 2290, 6026, 3]}, "items": [{"id": "p_662", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_663", "content": "hyperammonemia [SEP] ion by diazepam, but NH4Ac treatment alone had no effect. Thus, hyperammonemia is capable of altering drug action and must be considered along", "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 4755, 2007, 26079, 16, 2308, 14945, 1948, 2311, 4298, 2430, 2239, 2495, 18, 2842, 16, 4194, 2595, 2290, 6026, 1977, 7131, 1927, 12571, 2838, 4615, 3]}, "items": [{"id": "p_663", "content": "Hyperammonemia [SEP] Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 4664, 2237, 1927, 14880, 1922, 1920, 2877, 18, 2176, 1977, 43, 2105, 1927, 9785, 19480, 1927, 3835, 4576, 2014, 14880, 1942, 10505, 18, 3]}]}
{"query": {"id": "q_664", "content": "liver disease [SEP] ired drug metabolism in enhanced drug responses associated with liver disease. Experiments in vitro showed that acetylcholine-induced catecho", "tokenized_content": [2, 3568, 2573, 3, 13439, 1007, 2838, 4714, 1922, 4256, 2838, 3387, 2458, 1956, 3568, 2573, 18, 3144, 1922, 3596, 2594, 1988, 14561, 17, 2719, 12519, 1037, 3]}, "items": [{"id": "p_664", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_665", "content": "acetylcholine [SEP] associated with liver disease. Experiments in vitro showed that acetylcholine-induced catecholamine release from bovine adrenal medulla is de", "tokenized_content": [2, 14561, 3, 2458, 1956, 3568, 2573, 18, 3144, 1922, 3596, 2594, 1988, 14561, 17, 2719, 23483, 4012, 2037, 6970, 10651, 18755, 1977, 2028, 3]}, "items": [{"id": "p_665", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_666", "content": "catecholamine [SEP] disease. Experiments in vitro showed that acetylcholine-induced catecholamine release from bovine adrenal medulla is depressed as much as 50%", "tokenized_content": [2, 23483, 3, 2573, 18, 3144, 1922, 3596, 2594, 1988, 14561, 17, 2719, 23483, 4012, 2037, 6970, 10651, 18755, 1977, 11365, 1966, 4186, 1966, 2761, 9, 3]}, "items": [{"id": "p_666", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_667", "content": "KCl [SEP] adrenal medulla is depressed as much as 50% by 0.3 mM NH4Ac and KCl-induced contractions of guinea-pig ileum were inhibited 20% by ", "tokenized_content": [2, 10386, 3, 10651, 18755, 1977, 11365, 1966, 4186, 1966, 2761, 9, 2007, 20, 18, 23, 2489, 14945, 1948, 1930, 10386, 17, 2719, 15465, 1927, 12938, 17, 5445, 19269, 1985, 5069, 3]}, "items": [{"id": "p_667", "content": "Potassium Chloride [SEP] A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and", "score": 1, "type": null, "tokenized_content": [2, 9057, 9140, 3, 43, 4511, 6561, 2014, 14631, 10201, 2251, 1922, 19501, 31, 26179, 1036, 31, 1930, 22911, 5706, 18, 2176, 2112, 1998, 2251, 1942, 24549, 2471, 25308, 1930, 3]}]}
{"query": {"id": "q_668", "content": "calcium [SEP] -pig ileum were inhibited 20% by 5 mM NH4Ac. Addition of excess calcium reversed the depression in both tissues, but calcium-independen", "tokenized_content": [2, 5016, 3, 17, 5445, 19269, 1985, 5069, 2036, 9, 2007, 25, 2489, 14945, 1948, 18, 2459, 1927, 5799, 5016, 9432, 1920, 4621, 1922, 2321, 3878, 16, 2308, 5016, 17, 5910, 3]}, "items": [{"id": "p_668", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_669", "content": "depression [SEP] ited 20% by 5 mM NH4Ac. Addition of excess calcium reversed the depression in both tissues, but calcium-independent catecholamine release ", "tokenized_content": [2, 4621, 3, 2176, 1919, 2036, 9, 2007, 25, 2489, 14945, 1948, 18, 2459, 1927, 5799, 5016, 9432, 1920, 4621, 1922, 2321, 3878, 16, 2308, 5016, 17, 3484, 23483, 4012, 3]}, "items": [{"id": "p_669", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_670", "content": "acetaldehyde [SEP]  both tissues, but calcium-independent catecholamine release by acetaldehyde was not blocked by NH4Ac. These results suggested that ammonia ", "tokenized_content": [2, 29141, 3, 2321, 3878, 16, 2308, 5016, 17, 3484, 23483, 4012, 2007, 29141, 1982, 2084, 6923, 2007, 14945, 1948, 18, 2144, 2274, 3978, 1988, 14880, 3]}, "items": [{"id": "p_670", "content": "Acetaldehyde [SEP] A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the m", "score": 1, "type": null, "tokenized_content": [2, 29141, 3, 43, 29500, 16, 2300, 24788, 7272, 5875, 2251, 1922, 1920, 24021, 1927, 13069, 2687, 16, 5294, 24694, 16, 1930, 26703, 1036, 18, 2176, 1977, 2222, 1925, 6129, 1922, 1920, 55, 3]}]}
{"query": {"id": "q_671", "content": "ammonia [SEP] aldehyde was not blocked by NH4Ac. These results suggested that ammonia blocks calcium channels. Parallels in the actions of NH4Ac and ", "tokenized_content": [2, 14880, 3, 18727, 1982, 2084, 6923, 2007, 14945, 1948, 18, 2144, 2274, 3978, 1988, 14880, 7644, 5016, 5628, 18, 26246, 1922, 1920, 7728, 1927, 14945, 1948, 1930, 3]}, "items": [{"id": "p_671", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_672", "content": "verapamil [SEP] rallels in the actions of NH4Ac and the calcium channel blocker verapamil support this concept. Both verapamil (10 mg/kg i.p.) and NH4Ac ", "tokenized_content": [2, 23300, 3, 15906, 1952, 4668, 1922, 1920, 7728, 1927, 14945, 1948, 1930, 1920, 5016, 4999, 14580, 23300, 3373, 2052, 5658, 18, 2321, 23300, 12, 2119, 2786, 19, 3621, 51, 18, 3]}, "items": [{"id": "p_672", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_673", "content": "analgesia [SEP] apamil (10 mg/kg i.p.) and NH4Ac pretreatment enhanced morphine analgesia- and diazepam-induced muscular incoordination and antagonized a", "tokenized_content": [2, 14695, 3, 24162, 7395, 1024, 12, 2119, 2786, 19, 3621, 51, 18, 58, 18, 13, 1930, 14945, 1948, 9111, 4256, 11553, 14695, 17, 1930, 26079, 17, 2719, 12330, 2043, 8883, 3]}, "items": [{"id": "p_673", "content": "Pain Insensitivity, Congenital [SEP] A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent cor", "score": 1, "type": null, "tokenized_content": [2, 3594, 30055, 16, 9901, 3, 43, 4741, 4378, 2007, 2063, 11307, 2055, 1942, 3594, 4281, 1920, 3682, 1942, 7279, 24218, 2037, 2447, 17, 24218, 5458, 18, 7685, 2233, 3]}]}
{"query": {"id": "q_674", "content": "amphetamine [SEP] a- and diazepam-induced muscular incoordination and antagonized amphetamine-induced motor activity, and neither verapamil nor NH4Ac affecte", "tokenized_content": [2, 19057, 3, 43, 17, 1930, 26079, 17, 2719, 12330, 2043, 8883, 22816, 1943, 1930, 29368, 19057, 17, 2719, 4842, 2455, 16, 1930, 7132, 23300, 3990, 14945, 1948, 4081, 1021, 3]}, "items": [{"id": "p_674", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_675", "content": "metrazol [SEP] d neither verapamil nor NH4Ac affected the convulsant action of metrazol. The data suggest that hyperammonemia exerts a calcium channel ", "tokenized_content": [2, 2130, 5524, 13642, 1024, 3, 46, 7132, 23300, 3990, 14945, 1948, 4218, 1920, 4772, 6325, 2031, 4615, 1927, 2130, 5524, 13642, 1024, 18, 1920, 2230, 3220, 1988, 4194, 2595, 2290, 3]}, "items": [{"id": "p_675", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_676", "content": "nephropathy [SEP] Risk of nephropathy after consumption of nonionic contrast media by children underg", "tokenized_content": [2, 15582, 3, 2565, 1927, 15582, 2256, 5434, 1927, 2447, 14207, 3320, 4996, 2007, 3069, 12204, 3]}, "items": [{"id": "p_676", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_677", "content": "contrast media [SEP] Risk of nephropathy after consumption of nonionic contrast media by children undergoing cardiac angiography: a prospective study", "tokenized_content": [2, 3320, 4996, 3, 2565, 1927, 15582, 2256, 5434, 1927, 2447, 14207, 3320, 4996, 2007, 3069, 7258, 4435, 11676, 30, 43, 6315, 2161, 3]}, "items": [{"id": "p_677", "content": "Contrast Media [SEP] Substances used to allow enhanced visualization of tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3320, 4996, 3, 10054, 2251, 1942, 3235, 4256, 9966, 1927, 3878, 18, 3]}]}
{"query": {"id": "q_678", "content": "contrast media [SEP] Despite increasing reports on nonionic contrast media-induced nephropathy (CIN) in hospitalized adult patients during", "tokenized_content": [2, 3320, 4996, 3, 4281, 3605, 4710, 1990, 2447, 14207, 3320, 4996, 17, 2719, 15582, 12, 10510, 13, 1922, 13123, 4160, 2132, 2409, 3]}, "items": [{"id": "p_678", "content": "Contrast Media [SEP] Substances used to allow enhanced visualization of tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3320, 4996, 3, 10054, 2251, 1942, 3235, 4256, 9966, 1927, 3878, 18, 3]}]}
{"query": {"id": "q_679", "content": "nephropathy [SEP] Despite increasing reports on nonionic contrast media-induced nephropathy (CIN) in hospitalized adult patients during cardiac procedures,", "tokenized_content": [2, 15582, 3, 4281, 3605, 4710, 1990, 2447, 14207, 3320, 4996, 17, 2719, 15582, 12, 10510, 13, 1922, 13123, 4160, 2132, 2409, 4435, 4869, 16, 3]}, "items": [{"id": "p_679", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_680", "content": "CIN [SEP] reasing reports on nonionic contrast media-induced nephropathy (CIN) in hospitalized adult patients during cardiac procedures, the ", "tokenized_content": [2, 10510, 3, 4196, 1941, 4710, 1990, 2447, 14207, 3320, 4996, 17, 2719, 15582, 12, 10510, 13, 1922, 13123, 4160, 2132, 2409, 4435, 4869, 16, 1920, 3]}, "items": [{"id": "p_680", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_681", "content": "CM [SEP] etermined the incidence of CIN for two nonionic contrast media (CM), iopromide and iohexol, among 80 patients younger than 18 year", "tokenized_content": [2, 3195, 3, 2140, 24385, 1920, 4332, 1927, 10510, 1958, 2288, 2447, 14207, 3320, 4996, 12, 3195, 13, 16, 12906, 2018, 2261, 1930, 21509, 17797, 1945, 16, 2706, 3729, 2132, 7237, 3]}, "items": [{"id": "p_681", "content": "Contrast Media [SEP] Substances used to allow enhanced visualization of tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3320, 4996, 3, 10054, 2251, 1942, 3235, 4256, 9966, 1927, 3878, 18, 3]}]}
{"query": {"id": "q_682", "content": "iopromide [SEP] ined the incidence of CIN for two nonionic contrast media (CM), iopromide and iohexol, among 80 patients younger than 18 years and compar", "tokenized_content": [2, 12906, 2018, 2261, 3, 11116, 1007, 1920, 4332, 1927, 10510, 1958, 2288, 2447, 14207, 3320, 4996, 12, 3195, 13, 16, 12906, 2018, 2261, 1930, 21509, 17797, 1945, 16, 2706, 3729, 3]}, "items": [{"id": "p_682", "content": "iopromide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12906, 2018, 2261, 3, 3]}]}
{"query": {"id": "q_683", "content": "iohexol [SEP] ence of CIN for two nonionic contrast media (CM), iopromide and iohexol, among 80 patients younger than 18 years and compared the rates", "tokenized_content": [2, 21509, 17797, 1945, 3, 3350, 1021, 1927, 10510, 1958, 2288, 2447, 14207, 3320, 4996, 12, 3195, 13, 16, 12906, 2018, 2261, 1930, 21509, 17797, 1945, 16, 2706, 3729, 2132, 7237, 3]}, "items": [{"id": "p_683", "content": "Iohexol [SEP] An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriograph", "score": 1, "type": null, "tokenized_content": [2, 21509, 17797, 1945, 3, 1925, 3655, 2447, 17, 11478, 16, 3224, 17, 6622, 3320, 5899, 2154, 1977, 2251, 1922, 5707, 3796, 16, 9273, 6405, 5524, 25818, 16, 7737, 1931, 9506, 3796, 16, 12480, 2893, 3]}]}
{"query": {"id": "q_684", "content": "cyanosis [SEP] on in relation to the type and dosage of CM and the presence of cyanosis. The 80 patients in the study consecutively received either iop", "tokenized_content": [2, 26898, 8362, 3, 1990, 1922, 6147, 1942, 1920, 2601, 1930, 9998, 1927, 3195, 1930, 1920, 2990, 1927, 26898, 8362, 18, 1920, 3729, 2132, 1922, 1920, 2161, 22304, 4004, 3108, 12906, 3]}, "items": [{"id": "p_684", "content": "Cyanosis [SEP] A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin ", "score": 1, "type": null, "tokenized_content": [2, 26898, 8362, 3, 43, 2266, 15641, 2014, 25945, 2951, 2863, 18778, 1943, 1927, 1920, 4407, 1930, 27103, 5726, 2810, 1942, 1925, 2760, 1922, 1920, 4351, 1927, 16333, 2432, 1981, 9652, 3]}]}
{"query": {"id": "q_685", "content": "sodium [SEP] iopromide (group A, n = 40) or iohexol (group B, n = 40). Serum sodium (Na), potassium (K), and creatinine (Cr) were measured 24 h bef", "tokenized_content": [2, 5227, 3, 12906, 2018, 2261, 12, 2210, 43, 16, 56, 33, 3040, 13, 2014, 21509, 17797, 1945, 12, 2210, 44, 16, 56, 33, 3040, 13, 18, 3256, 5227, 12, 4049, 3]}, "items": [{"id": "p_685", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_686", "content": "Na [SEP] e (group A, n = 40) or iohexol (group B, n = 40). Serum sodium (Na), potassium (K), and creatinine (Cr) were measured 24 h before ", "tokenized_content": [2, 4049, 3, 47, 12, 2210, 43, 16, 56, 33, 3040, 13, 2014, 21509, 17797, 1945, 12, 2210, 44, 16, 56, 33, 3040, 13, 18, 3256, 5227, 12, 4049, 13, 16, 3]}, "items": [{"id": "p_686", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_687", "content": "potassium [SEP] oup A, n = 40) or iohexol (group B, n = 40). Serum sodium (Na), potassium (K), and creatinine (Cr) were measured 24 h before angiography ", "tokenized_content": [2, 9057, 3, 17208, 1034, 43, 16, 56, 33, 3040, 13, 2014, 21509, 17797, 1945, 12, 2210, 44, 16, 56, 33, 3040, 13, 18, 3256, 5227, 12, 4049, 13, 16, 9057, 3]}, "items": [{"id": "p_687", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_688", "content": "K [SEP] 40) or iohexol (group B, n = 40). Serum sodium (Na), potassium (K), and creatinine (Cr) were measured 24 h before angiography as ", "tokenized_content": [2, 53, 3, 3040, 13, 2014, 21509, 17797, 1945, 12, 2210, 44, 16, 56, 33, 3040, 13, 18, 3256, 5227, 12, 4049, 13, 16, 9057, 12, 53, 13, 16, 1930, 9374, 3]}, "items": [{"id": "p_688", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_689", "content": "creatinine [SEP] ohexol (group B, n = 40). Serum sodium (Na), potassium (K), and creatinine (Cr) were measured 24 h before angiography as baseline values, ", "tokenized_content": [2, 9374, 3, 5622, 2783, 1945, 12, 2210, 44, 16, 56, 33, 3040, 13, 18, 3256, 5227, 12, 4049, 13, 16, 9057, 12, 53, 13, 16, 1930, 9374, 12, 2345, 13, 3]}, "items": [{"id": "p_689", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_690", "content": "Cr [SEP] p B, n = 40). Serum sodium (Na), potassium (K), and creatinine (Cr) were measured 24 h before angiography as baseline values, then", "tokenized_content": [2, 2345, 3, 58, 44, 16, 56, 33, 3040, 13, 18, 3256, 5227, 12, 4049, 13, 16, 9057, 12, 53, 13, 16, 1930, 9374, 12, 2345, 13, 1985, 3045, 2686, 50, 3]}, "items": [{"id": "p_690", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_691", "content": "renal failure [SEP]  for Na and Cr also were checked at the same intervals. Risk of renal failure, Injury to the kidney, Failure of kidney function, Loss of kidn", "tokenized_content": [2, 4604, 4574, 3, 1958, 4049, 1930, 2345, 2222, 1985, 11366, 2019, 1920, 2841, 6087, 18, 2565, 1927, 4604, 4574, 16, 4047, 1942, 1920, 5245, 16, 4574, 1927, 5245, 2347, 16, 3]}, "items": [{"id": "p_691", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_692", "content": "Injury to the kidney [SEP] also were checked at the same intervals. Risk of renal failure, Injury to the kidney, Failure of kidney function, Loss of kidney function, and End-s", "tokenized_content": [2, 4047, 1942, 1920, 5245, 3, 2222, 1985, 11366, 2019, 1920, 2841, 6087, 18, 2565, 1927, 4604, 4574, 16, 4047, 1942, 1920, 5245, 16, 4574, 1927, 5245, 2347, 16, 3257, 1927, 3]}, "items": [{"id": "p_692", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_693", "content": "Failure of kidney function [SEP] he same intervals. Risk of renal failure, Injury to the kidney, Failure of kidney function, Loss of kidney function, and End-stage renal damage (RIFLE cri", "tokenized_content": [2, 4574, 1927, 5245, 2347, 3, 2234, 2841, 6087, 18, 2565, 1927, 4604, 4574, 16, 4047, 1942, 1920, 5245, 16, 4574, 1927, 5245, 2347, 16, 3257, 1927, 5245, 2347, 16, 1930, 3]}, "items": [{"id": "p_693", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_694", "content": "Loss of kidney function [SEP] enal failure, Injury to the kidney, Failure of kidney function, Loss of kidney function, and End-stage renal damage (RIFLE criteria) were used to defin", "tokenized_content": [2, 3257, 1927, 5245, 2347, 3, 2066, 1923, 4574, 16, 4047, 1942, 1920, 5245, 16, 4574, 1927, 5245, 2347, 16, 3257, 1927, 5245, 2347, 16, 1930, 2482, 17, 3587, 4604, 4293, 3]}, "items": [{"id": "p_694", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_695", "content": "renal damage [SEP] lure of kidney function, Loss of kidney function, and End-stage renal damage (RIFLE criteria) were used to define CIN and its incidence in t", "tokenized_content": [2, 4604, 4293, 3, 10908, 1936, 1927, 5245, 2347, 16, 3257, 1927, 5245, 2347, 16, 1930, 2482, 17, 3587, 4604, 4293, 12, 12424, 1952, 4164, 13, 1985, 2251, 1942, 7425, 10510, 3]}, "items": [{"id": "p_695", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_696", "content": "renal injury [SEP] .5% of the patients in group A had increased risk and 3.75% had renal injury, whereas 5% of group B had increased risk and 2.5% had renal in", "tokenized_content": [2, 4604, 4047, 3, 18, 25, 9, 1927, 1920, 2132, 1922, 2210, 43, 2430, 2502, 2565, 1930, 23, 18, 4089, 9, 2430, 4604, 4047, 16, 3417, 25, 9, 1927, 2210, 44, 3]}, "items": [{"id": "p_696", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_697", "content": "congenital heart diseases [SEP]  CM (p = 0.014). Among the 15 patients with CIN, 6 had cyanotic congenital heart diseases, but the incidence did not differ significantly from that for t", "tokenized_content": [2, 9901, 4003, 3902, 3, 3195, 12, 58, 33, 20, 18, 17763, 13, 18, 2706, 1920, 2461, 2132, 1956, 10510, 16, 26, 2430, 26898, 2002, 9901, 4003, 3902, 16, 2308, 1920, 3]}, "items": [{"id": "p_697", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_698", "content": "ventricular tachycardia [SEP] A case of ventricular tachycardia related to caffeine pretreatment.", "tokenized_content": [2, 6493, 17397, 3, 43, 3087, 1927, 6493, 17397, 2712, 1942, 14119, 9111, 18, 3]}, "items": [{"id": "p_698", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_699", "content": "caffeine [SEP] A case of ventricular tachycardia related to caffeine pretreatment.", "tokenized_content": [2, 14119, 3, 43, 3087, 1927, 6493, 17397, 2712, 1942, 14119, 9111, 18, 3]}, "items": [{"id": "p_699", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_700", "content": "seizure [SEP] Suboptimal seizure duration is commonly encountered in electroconvulsive therapy p", "tokenized_content": [2, 11015, 3, 16337, 11015, 4392, 1977, 5384, 11989, 1922, 13142, 12766, 13042, 3181, 58, 3]}, "items": [{"id": "p_700", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_701", "content": "caffeine [SEP] y in older patients with higher seizure thresholds. Intravenous caffeine is commonly used to improve seizure duration and quality in suc", "tokenized_content": [2, 14119, 3, 67, 1922, 4706, 2132, 1956, 2580, 11015, 9761, 18, 7307, 14119, 1977, 5384, 2251, 1942, 3326, 11015, 4392, 1930, 3455, 1922, 2318, 3]}, "items": [{"id": "p_701", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_702", "content": "ventricular ectopy [SEP] ll tolerated aside from occasional reports of relatively benign ventricular ectopy. We describe a patient with no previous history of cardiac dise", "tokenized_content": [2, 6493, 7495, 14864, 3, 10748, 11117, 20828, 2037, 18838, 4710, 1927, 4322, 8867, 6493, 7495, 14864, 18, 2038, 5993, 43, 2774, 1956, 2239, 2555, 4403, 1927, 4435, 2445, 3]}, "items": [{"id": "p_702", "content": "Ventricular Premature Complexes [SEP] A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS compl", "score": 1, "type": null, "tokenized_content": [2, 6493, 9839, 5048, 3, 43, 2601, 1927, 4435, 18346, 1956, 9839, 15465, 1927, 1920, 4003, 21008, 18, 2176, 1977, 4378, 2007, 1920, 9839, 22355, 6581, 3]}]}
{"query": {"id": "q_703", "content": "cardiac disease [SEP] cular ectopy. We describe a patient with no previous history of cardiac disease or arrhythmia who developed sustained bigeminy and 2 brief runs", "tokenized_content": [2, 4435, 2573, 3, 6710, 1933, 7495, 14864, 18, 2038, 5993, 43, 2774, 1956, 2239, 2555, 4403, 1927, 4435, 2573, 2014, 18346, 2746, 3530, 7637, 9769, 1987, 1921, 1012, 1930, 22, 3]}, "items": [{"id": "p_703", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_704", "content": "arrhythmia [SEP] scribe a patient with no previous history of cardiac disease or arrhythmia who developed sustained bigeminy and 2 brief runs of ventricula", "tokenized_content": [2, 18346, 3, 7572, 2023, 1021, 43, 2774, 1956, 2239, 2555, 4403, 1927, 4435, 2573, 2014, 18346, 2746, 3530, 7637, 9769, 1987, 1921, 1012, 1930, 22, 5310, 12083, 1927, 4699, 16058, 3]}, "items": [{"id": "p_704", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_705", "content": "ventricular tachycardia [SEP] arrhythmia who developed sustained bigeminy and 2 brief runs of ventricular tachycardia after caffeine administration. Although intravenous caffeine is", "tokenized_content": [2, 6493, 17397, 3, 18346, 2746, 3530, 7637, 9769, 1987, 1921, 1012, 1930, 22, 5310, 12083, 1927, 6493, 17397, 2256, 14119, 4183, 18, 2876, 7307, 14119, 1977, 3]}, "items": [{"id": "p_705", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_706", "content": "ventricular arrhythmias [SEP]  should be aware of the potential for unpredictable and serious ventricular arrhythmias.", "tokenized_content": [2, 6493, 16934, 3, 3066, 1998, 11207, 1927, 1920, 2889, 1958, 22512, 1930, 7433, 6493, 16934, 18, 3]}, "items": [{"id": "p_706", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_707", "content": "ethambutol [SEP] l coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy.", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 54, 13138, 7876, 2112, 2931, 10623, 3257, 1922, 2132, 1956, 3293, 6739, 1984, 1945, 17, 2719, 10109, 13177, 18, 3]}, "items": [{"id": "p_707", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_708", "content": "optic neuropathy [SEP] phy can measure axonal loss in patients with ethambutol-induced optic neuropathy.", "tokenized_content": [2, 10109, 13177, 3, 2087, 1012, 2112, 2931, 10623, 3257, 1922, 2132, 1956, 3293, 6739, 1984, 1945, 17, 2719, 10109, 13177, 18, 3]}, "items": [{"id": "p_708", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_709", "content": "axonal degeneration [SEP] PURPOSE: To map and identify the pattern, in vivo, of axonal degeneration in ethambutol-induced optic neuropathy using optical coherence ", "tokenized_content": [2, 10623, 9174, 3, 5120, 30, 1942, 4446, 1930, 3512, 1920, 3114, 16, 1922, 3597, 16, 1927, 10623, 9174, 1922, 3293, 6739, 1984, 1945, 17, 2719, 10109, 13177, 2193, 6322, 13138, 3]}, "items": [{"id": "p_709", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_710", "content": "ethambutol [SEP] ap and identify the pattern, in vivo, of axonal degeneration in ethambutol-induced optic neuropathy using optical coherence tomography (OC", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 2100, 1930, 3512, 1920, 3114, 16, 1922, 3597, 16, 1927, 10623, 9174, 1922, 3293, 6739, 1984, 1945, 17, 2719, 10109, 13177, 2193, 6322, 13138, 7876, 3]}, "items": [{"id": "p_710", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_711", "content": "optic neuropathy [SEP]  pattern, in vivo, of axonal degeneration in ethambutol-induced optic neuropathy using optical coherence tomography (OCT). Ethambutol is an anti", "tokenized_content": [2, 10109, 13177, 3, 3114, 16, 1922, 3597, 16, 1927, 10623, 9174, 1922, 3293, 6739, 1984, 1945, 17, 2719, 10109, 13177, 2193, 6322, 13138, 7876, 12, 5843, 13, 18, 3293, 6739, 3]}, "items": [{"id": "p_711", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_712", "content": "Ethambutol [SEP] uced optic neuropathy using optical coherence tomography (OCT). Ethambutol is an antimycobacterial agent often used to treat tuberculosis.", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 8577, 1919, 10109, 13177, 2193, 6322, 13138, 7876, 12, 5843, 13, 18, 3293, 6739, 1984, 1945, 1977, 1925, 20330, 2773, 15229, 5899, 3868, 2251, 1942, 3]}, "items": [{"id": "p_712", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_713", "content": "tuberculosis [SEP] ). Ethambutol is an antimycobacterial agent often used to treat tuberculosis. A serious complication of ethambutol is an optic neuropathy th", "tokenized_content": [2, 8449, 3, 13, 18, 3293, 6739, 1984, 1945, 1977, 1925, 20330, 2773, 15229, 5899, 3868, 2251, 1942, 2297, 8449, 18, 43, 7433, 9388, 1927, 3293, 6739, 1984, 1945, 1977, 1925, 3]}, "items": [{"id": "p_713", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_714", "content": "EMB [SEP]  to miss. METHODS: Three subjects with a history of ethambutol (EMB)-induced optic neuropathy of short-, intermediate-, and long-te", "tokenized_content": [2, 5654, 3, 1942, 5276, 18, 2860, 30, 2559, 3297, 1956, 43, 4403, 1927, 3293, 6739, 1984, 1945, 12, 5654, 13, 17, 2719, 10109, 13177, 1927, 3662, 17, 16, 6129, 17, 3]}, "items": [{"id": "p_714", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_715", "content": "visual deficits [SEP] nduced optic neuropathy of short-, intermediate-, and long-term visual deficits were administered a full neuro-ophthalmologic examination inclu", "tokenized_content": [2, 3737, 7961, 3, 8026, 2418, 10109, 13177, 1927, 3662, 17, 16, 6129, 17, 16, 1930, 2815, 17, 2576, 3737, 7961, 1985, 5254, 43, 4125, 3366, 17, 14554, 4467, 4981, 2296, 3]}, "items": [{"id": "p_715", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_716", "content": "optic neuropathies [SEP] axons) within the papillo-macular bundle in toxic or hereditary optic neuropathies. OCT can be a valuable tool in the quantitative analysis of opt", "tokenized_content": [2, 10109, 8798, 2062, 3, 9725, 13, 2651, 1920, 14668, 1037, 17, 14453, 14142, 1922, 6161, 2014, 16321, 10109, 8798, 2062, 18, 5843, 2112, 1998, 43, 8619, 5229, 1922, 1920, 4794, 3]}, "items": [{"id": "p_716", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_717", "content": "renal impairment [SEP] important to properly manage ethambutol dosing in patients with renal impairment and to achieve proper transition to a maintenance dose once an ", "tokenized_content": [2, 4604, 6159, 3, 2715, 1942, 12846, 12193, 3293, 6739, 1984, 1945, 10654, 1922, 2132, 1956, 4604, 6159, 1930, 1942, 6230, 3405, 4832, 1942, 43, 6291, 3253, 5361, 1925, 3]}, "items": [{"id": "p_717", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_718", "content": "valdecoxib [SEP] Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on card", "tokenized_content": [2, 2326, 3695, 4879, 18068, 1014, 3, 2564, 1927, 1920, 21271, 17, 22, 2487, 4106, 2326, 3695, 4879, 18068, 1014, 4072, 29413, 2246, 9899, 4820, 1930, 5936, 1990, 9429, 3]}, "items": [{"id": "p_718", "content": "valdecoxib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2326, 3695, 4879, 18068, 1014, 3, 3]}]}
{"query": {"id": "q_719", "content": "thrombotic [SEP] steroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis.", "tokenized_content": [2, 21039, 3, 24932, 2246, 9899, 4820, 1930, 5936, 1990, 5321, 21039, 3916, 1922, 2132, 1956, 8884, 18, 3]}, "items": [{"id": "p_719", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_720", "content": "arthritis [SEP] nd placebo on cardiovascular thrombotic events in patients with arthritis.", "tokenized_content": [2, 8884, 3, 8026, 5936, 1990, 5321, 21039, 3916, 1922, 2132, 1956, 8884, 18, 3]}, "items": [{"id": "p_720", "content": "Arthritis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8884, 3, 3]}]}
{"query": {"id": "q_721", "content": "thrombotic [SEP] There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhib", "tokenized_content": [2, 21039, 3, 2276, 2162, 2252, 8103, 1988, 1920, 2565, 1927, 5321, 21039, 3916, 2278, 1998, 2580, 1956, 21271, 12, 6374, 13, 17, 22, 17, 2487, 2439, 3]}, "items": [{"id": "p_721", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_722", "content": "valdecoxib [SEP] tory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients ", "tokenized_content": [2, 2326, 3695, 4879, 18068, 1014, 3, 8184, 1012, 4195, 12, 17739, 13, 18, 2038, 3747, 5321, 4817, 2230, 1958, 2326, 3695, 4879, 18068, 1014, 16, 43, 2814, 6374, 17, 22, 3]}, "items": [{"id": "p_722", "content": "valdecoxib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2326, 3695, 4879, 18068, 1014, 3, 3]}]}
{"query": {"id": "q_723", "content": "osteoarthritis [SEP] ew COX-2-specific inhibitor in approximately 8000 patients with osteoarthritis and rheumatoid arthritis treated with this agent in randomized ", "tokenized_content": [2, 15027, 3, 13812, 6374, 17, 22, 17, 2487, 4106, 1922, 3993, 25328, 2132, 1956, 15027, 1930, 13053, 8884, 2868, 1956, 2052, 5899, 1922, 5542, 3]}, "items": [{"id": "p_723", "content": "Osteoarthritis [SEP] A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is though", "score": 1, "type": null, "tokenized_content": [2, 15027, 3, 43, 7529, 16, 15676, 6047, 2573, 16, 1920, 2501, 3059, 2386, 1927, 8884, 16, 4369, 1922, 4706, 7618, 18, 1920, 2573, 1977, 4170, 3]}]}
{"query": {"id": "q_724", "content": "rheumatoid arthritis [SEP] nhibitor in approximately 8000 patients with osteoarthritis and rheumatoid arthritis treated with this agent in randomized clinical trials. The inci", "tokenized_content": [2, 13053, 8884, 3, 5331, 2023, 6733, 1922, 3993, 25328, 2132, 1956, 15027, 1930, 13053, 8884, 2868, 1956, 2052, 5899, 1922, 5542, 2535, 3848, 18, 1920, 2043, 1033, 3]}, "items": [{"id": "p_724", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_725", "content": "diclofenac [SEP] alyzing pooled valdecoxib (10-80 mg daily), nonselective NSAID (diclofenac 75 mg bid, ibuprofen 800 mg tid, or naproxen 500 mg bid) and pl", "tokenized_content": [2, 27304, 3, 1969, 2904, 1941, 7803, 2326, 3695, 4879, 18068, 1014, 12, 2119, 17, 3729, 2786, 4692, 13, 16, 6771, 25568, 24194, 12, 27304, 4089, 2786, 12355, 16, 24089, 9658, 3]}, "items": [{"id": "p_725", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_726", "content": "ibuprofen [SEP] xib (10-80 mg daily), nonselective NSAID (diclofenac 75 mg bid, ibuprofen 800 mg tid, or naproxen 500 mg bid) and placebo data from 10 ra", "tokenized_content": [2, 24089, 3, 11551, 1014, 12, 2119, 17, 3729, 2786, 4692, 13, 16, 6771, 25568, 24194, 12, 27304, 4089, 2786, 12355, 16, 24089, 9658, 2786, 8685, 1007, 16, 2014, 14290, 12222, 3]}, "items": [{"id": "p_726", "content": "Ibuprofen [SEP] A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24089, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 14501, 3879, 2251, 1922, 1920, 3181, 1927, 10939, 2421, 1930, 8884, 18, 3]}]}
{"query": {"id": "q_727", "content": "naproxen [SEP] selective NSAID (diclofenac 75 mg bid, ibuprofen 800 mg tid, or naproxen 500 mg bid) and placebo data from 10 randomized osteoarthritis ", "tokenized_content": [2, 14290, 12222, 1917, 3, 5328, 24194, 12, 27304, 4089, 2786, 12355, 16, 24089, 9658, 2786, 8685, 1007, 16, 2014, 14290, 12222, 1917, 4599, 2786, 12355, 13, 1930, 5936, 2230, 2037, 3]}, "items": [{"id": "p_727", "content": "Naproxen [SEP] An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatmen", "score": 1, "type": null, "tokenized_content": [2, 14290, 12222, 1917, 3, 1925, 2246, 17, 3769, 5899, 1956, 14501, 1930, 2246, 18425, 3023, 3879, 18, 2321, 1920, 2687, 1930, 2496, 5227, 7012, 2032, 2251, 1922, 1920, 2297, 19047, 3]}]}
{"query": {"id": "q_728", "content": "aspirin [SEP] tients (n = 7934) and in users of low-dose (< or =325 mg daily) aspirin (n = 1051) and nonusers of aspirin (n = 6883). Crude and exposu", "tokenized_content": [2, 12396, 3, 19108, 4905, 1036, 12, 56, 33, 5637, 4857, 13, 1930, 1922, 6603, 1927, 2330, 17, 3253, 12, 32, 2014, 33, 21059, 2786, 4692, 13, 12396, 12, 56, 33, 3]}, "items": [{"id": "p_728", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_729", "content": "Thrombotic [SEP] us thrombotic events was also similar for each valdecoxib dose. Thrombotic risk was consistently higher for users of aspirin users than no", "tokenized_content": [2, 21039, 3, 2022, 21039, 3916, 1982, 2222, 2551, 1958, 2362, 2326, 3695, 4879, 18068, 1014, 3253, 18, 21039, 2565, 1982, 7522, 2580, 1958, 6603, 1927, 12396, 6603, 2254, 2239, 3]}, "items": [{"id": "p_729", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_730", "content": "ephedrine [SEP] A randomized, placebo-controlled, crossover study of ephedrine for SSRI-induced female sexual dysfunction.", "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 5542, 16, 5936, 17, 4642, 16, 15845, 2161, 1927, 12717, 1919, 5773, 1958, 29494, 17, 2719, 4232, 5702, 5273, 18, 3]}, "items": [{"id": "p_730", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_731", "content": "sexual dysfunction [SEP] ontrolled, crossover study of ephedrine for SSRI-induced female sexual dysfunction.", "tokenized_content": [2, 5702, 5273, 3, 9056, 26671, 1919, 16, 15845, 2161, 1927, 12717, 1919, 5773, 1958, 29494, 17, 2719, 4232, 5702, 5273, 18, 3]}, "items": [{"id": "p_731", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_732", "content": "ephedrine [SEP] The objective of this study was to determine whether ephedrine, an alpha- and beta-adrenergic agonist previously shown to enha", "tokenized_content": [2, 12717, 1919, 5773, 3, 1920, 4470, 1927, 2052, 2161, 1982, 1942, 3415, 3053, 12717, 1919, 5773, 16, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 3024, 2522, 1942, 3102, 1019, 3]}, "items": [{"id": "p_732", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_733", "content": "sexual dysfunction [SEP] men, has beneficial effects in reversing antidepressant-induced sexual dysfunction. Nineteen sexually dysfunctional women receiving either fluoxet", "tokenized_content": [2, 5702, 5273, 3, 3925, 16, 2258, 6928, 2564, 1922, 26526, 14183, 17, 2719, 5702, 5273, 18, 24354, 14427, 18758, 3089, 5962, 3108, 26915, 1039, 1946, 3]}, "items": [{"id": "p_733", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_734", "content": "sexually dysfunctional [SEP] n reversing antidepressant-induced sexual dysfunction. Nineteen sexually dysfunctional women receiving either fluoxetine, sertraline, or paroxetine pa", "tokenized_content": [2, 14427, 18758, 3, 56, 26526, 14183, 17, 2719, 5702, 5273, 18, 24354, 14427, 18758, 3089, 5962, 3108, 22176, 16, 17498, 7317, 2053, 16, 2014, 21412, 15387, 3838, 3]}, "items": [{"id": "p_734", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_735", "content": "fluoxetine [SEP] unction. Nineteen sexually dysfunctional women receiving either fluoxetine, sertraline, or paroxetine participated in an eight-week, doubl", "tokenized_content": [2, 22176, 3, 5269, 1929, 18, 24354, 14427, 18758, 3089, 5962, 3108, 22176, 16, 17498, 7317, 2053, 16, 2014, 21412, 15387, 7813, 1922, 1925, 5066, 17, 2982, 16, 8993, 1024, 3]}, "items": [{"id": "p_735", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_736", "content": "sertraline [SEP] eteen sexually dysfunctional women receiving either fluoxetine, sertraline, or paroxetine participated in an eight-week, double-blind, pla", "tokenized_content": [2, 17498, 7317, 2053, 3, 2140, 21115, 14427, 18758, 3089, 5962, 3108, 22176, 16, 17498, 7317, 2053, 16, 2014, 21412, 15387, 7813, 1922, 1925, 5066, 17, 2982, 16, 4825, 17, 7109, 3]}, "items": [{"id": "p_736", "content": "Sertraline [SEP] A selective serotonin uptake inhibitor that is used in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17498, 7317, 2053, 3, 43, 5328, 11153, 5047, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_737", "content": "paroxetine [SEP] dysfunctional women receiving either fluoxetine, sertraline, or paroxetine participated in an eight-week, double-blind, placebo-controlled", "tokenized_content": [2, 21412, 15387, 3, 18758, 3089, 5962, 3108, 22176, 16, 17498, 7317, 2053, 16, 2014, 21412, 15387, 7813, 1922, 1925, 5066, 17, 2982, 16, 4825, 17, 7109, 16, 5936, 17, 4642, 3]}, "items": [{"id": "p_737", "content": "Paroxetine [SEP] A serotonin uptake inhibitor that is effective in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21412, 15387, 3, 43, 11153, 5047, 4106, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_738", "content": "Erectile dysfunction [SEP] Erectile dysfunction occurs following substantia nigra lesions in the rat.", "tokenized_content": [2, 24686, 5273, 3, 24686, 5273, 5110, 2894, 21229, 20102, 4518, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_738", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_739", "content": "6-hydroxydopamine [SEP] was assessed 6 weeks following uni- and bilateral injections of 6-hydroxydopamine in the substantia nigra nucleus of the brain. Behavioral apomor", "tokenized_content": [2, 26, 17, 8275, 22389, 4302, 25157, 3, 1982, 3683, 26, 3625, 2894, 24386, 17, 1930, 7787, 8775, 1927, 26, 17, 8275, 22389, 4302, 25157, 1922, 1920, 21229, 20102, 5607, 1927, 3]}, "items": [{"id": "p_739", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_740", "content": "apomorphine [SEP] pamine in the substantia nigra nucleus of the brain. Behavioral apomorphine-induced penile erections were reduced (5/8) and increased (3/8)", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 11888, 2053, 1922, 1920, 21229, 20102, 5607, 1927, 1920, 3068, 18, 5343, 11466, 12492, 11119, 7969, 2912, 17, 2719, 22609, 24311, 3104, 1985, 3028, 3]}, "items": [{"id": "p_740", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_741", "content": "dopamine [SEP] sed 6 weeks following uni- and bilateral injections of 6-hydroxydopamine in the substantia nigra nucleus of the brain. Behavioral apomor", "tokenized_content": [2, 7964, 3, 6276, 26, 3625, 2894, 24386, 17, 1930, 7787, 8775, 1927, 26, 17, 8275, 22389, 4302, 25157, 1922, 1920, 21229, 20102, 5607, 1927, 1920, 3068, 18, 5343, 11466, 12492, 3]}, "items": [{"id": "p_741", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_742", "content": "erectile dysfunction [SEP] . Lesions of the substantia nigra are therefore associated with erectile dysfunction in rats and may serve as a model to study erectile dysfunction ", "tokenized_content": [2, 24686, 5273, 3, 18, 4518, 1927, 1920, 21229, 20102, 2032, 2955, 2458, 1956, 24686, 5273, 1922, 3615, 1930, 2278, 7120, 1966, 43, 2322, 1942, 2161, 24686, 5273, 3]}, "items": [{"id": "p_742", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_743", "content": "Parkinson's disease [SEP]  rats and may serve as a model to study erectile dysfunction in Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 3615, 1930, 2278, 7120, 1966, 43, 2322, 1942, 2161, 24686, 5273, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_743", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_744", "content": "dopamine [SEP] Potential therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian le", "tokenized_content": [2, 7964, 3, 2889, 4272, 2485, 1927, 1920, 5328, 7964, 8524, 3148, 7829, 16, 43, 17, 5713, 11884, 1026, 30, 1925, 3939, 2161, 1922, 10124, 3122, 2071, 3]}, "items": [{"id": "p_744", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_745", "content": "A-86929 [SEP]  therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.", "tokenized_content": [2, 43, 17, 5713, 11884, 1026, 3, 4272, 2485, 1927, 1920, 5328, 7964, 8524, 3148, 7829, 16, 43, 17, 5713, 11884, 1026, 30, 1925, 3939, 2161, 1922, 10124, 3122, 26723, 17, 3]}, "items": [{"id": "p_745", "content": "A 86929 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 43, 5713, 11884, 1026, 3, 3]}]}
{"query": {"id": "q_746", "content": "parkinsonian [SEP] ective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.", "tokenized_content": [2, 10124, 3122, 3, 7495, 2320, 7964, 8524, 3148, 7829, 16, 43, 17, 5713, 11884, 1026, 30, 1925, 3939, 2161, 1922, 10124, 3122, 26723, 17, 14979, 11909, 18, 3]}, "items": [{"id": "p_746", "content": "Parkinsonian Disorders [SEP] A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural i", "score": 1, "type": null, "tokenized_content": [2, 10124, 3122, 4414, 3, 43, 2210, 1927, 4414, 2154, 5961, 5761, 4842, 2285, 4378, 2007, 20152, 26682, 16, 3760, 20471, 31, 18388, 31, 1930, 17198, 51, 3]}]}
{"query": {"id": "q_747", "content": "levodopa [SEP] ne D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.", "tokenized_content": [2, 26723, 3, 2069, 8524, 3148, 7829, 16, 43, 17, 5713, 11884, 1026, 30, 1925, 3939, 2161, 1922, 10124, 3122, 26723, 17, 14979, 11909, 18, 3]}, "items": [{"id": "p_747", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_748", "content": "dopamine [SEP] The clinical utility of dopamine (DA) D1 receptor agonists in the treatment of Parkinson's disea", "tokenized_content": [2, 7964, 3, 1920, 2535, 8531, 1927, 7964, 12, 3692, 13, 8524, 3148, 9849, 1922, 1920, 2311, 1927, 10124, 11, 61, 2445, 1019, 3]}, "items": [{"id": "p_748", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_749", "content": "DA [SEP] The clinical utility of dopamine (DA) D1 receptor agonists in the treatment of Parkinson's disease (", "tokenized_content": [2, 3692, 3, 1920, 2535, 8531, 1927, 7964, 12, 3692, 13, 8524, 3148, 9849, 1922, 1920, 2311, 1927, 10124, 11, 61, 2573, 12, 3]}, "items": [{"id": "p_749", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_750", "content": "Parkinson's disease [SEP] ility of dopamine (DA) D1 receptor agonists in the treatment of Parkinson's disease (PD) is still unclear. The therapeutic use of selective DA D1 r", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 14872, 3145, 1927, 7964, 12, 3692, 13, 8524, 3148, 9849, 1922, 1920, 2311, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 1977, 3974, 6390, 18, 3]}, "items": [{"id": "p_750", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_751", "content": "PD [SEP] ) D1 receptor agonists in the treatment of Parkinson's disease (PD) is still unclear. The therapeutic use of selective DA D1 recep", "tokenized_content": [2, 3203, 3, 13, 8524, 3148, 9849, 1922, 1920, 2311, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 1977, 3974, 6390, 18, 1920, 4272, 2485, 1927, 5328, 3692, 8524, 2793, 3]}, "items": [{"id": "p_751", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_752", "content": "SKF-82958 [SEP] he therapeutic use of selective DA D1 receptor agonists such as SKF-82958 (6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-", "tokenized_content": [2, 3097, 1038, 17, 6175, 8803, 1025, 3, 2234, 4272, 2485, 1927, 5328, 3692, 8524, 3148, 9849, 2427, 1966, 3097, 1038, 17, 6175, 8803, 1025, 12, 26, 17, 10107, 17, 27, 3]}, "items": [{"id": "p_752", "content": "SK&F 82958 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3097, 10, 48, 6175, 8803, 1025, 3, 3]}]}
{"query": {"id": "q_753", "content": "6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pine hydrobromide [SEP] tic use of selective DA D1 receptor agonists such as SKF-82958 (6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pine hydrobromide) and A-77636 ([1R, 3S] 3-[1'-admantyl]-1-aminomethyl-3,4-dihydr", "tokenized_content": [2, 26, 17, 10107, 17, 27, 16, 28, 17, 20684, 17, 23, 17, 28261, 17, 21, 17, 7971, 17, 22, 16, 23, 16, 24, 16, 25, 17, 21196, 17, 5189, 17, 3]}, "items": [{"id": "p_753", "content": "SK&F 82958 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3097, 10, 48, 6175, 8803, 1025, 3, 3]}]}
{"query": {"id": "q_754", "content": "A-77636 [SEP] 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pine hydrobromide) and A-77636 ([1R, 3S] 3-[1'-admantyl]-1-aminomethyl-3,4-dihydro-5,6-dihydro", "tokenized_content": [2, 43, 17, 5517, 7576, 1016, 3, 21, 17, 7971, 17, 22, 16, 23, 16, 24, 16, 25, 17, 21196, 17, 5189, 17, 23, 17, 7334, 3408, 1021, 17541, 3290, 18474, 3]}, "items": [{"id": "p_754", "content": "A 77636 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 43, 5517, 7576, 1016, 3, 3]}]}
{"query": {"id": "q_755", "content": "[1R, 3S] 3-[1'-admantyl]-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzo pyran hydrochloride [SEP] 2,3,4,5-tetrahydro-1H-3-benzaze pine hydrobromide) and A-77636 ([1R, 3S] 3-[1'-admantyl]-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzo pyran hydrochloride) seems limited because of their duration of action, which is to", "tokenized_content": [2, 37, 12926, 16, 27972, 39, 23, 17, 37, 21, 11, 17, 3034, 2031, 2199, 39, 17, 21, 17, 3835, 21312, 17, 23, 16, 24, 17, 11842, 17, 25, 16, 26, 3]}, "items": [{"id": "p_755", "content": "A 77636 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 43, 5517, 7576, 1016, 3, 3]}]}
{"query": {"id": "q_756", "content": "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] erefore conducted the present acute dose-response study in four 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed cynomolgus monkeys primed to exhibit levodopa-in", "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 22561, 2524, 3609, 1920, 2481, 3939, 3253, 17, 2644, 2161, 3]}, "items": [{"id": "p_756", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_757", "content": "MPTP [SEP] nse study in four 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed cynomolgus monkeys primed to exhibit levodopa-induced ", "tokenized_content": [2, 19043, 3, 28686, 2161, 1922, 3006, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 12, 19043, 13, 17, 4616, 3]}, "items": [{"id": "p_757", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_758", "content": "levodopa [SEP] dropyridine (MPTP)-exposed cynomolgus monkeys primed to exhibit levodopa-induced dyskinesias to evaluate the locomotor and dyskinetic ef", "tokenized_content": [2, 26723, 3, 7086, 3553, 5802, 12, 19043, 13, 17, 4616, 23836, 30351, 13057, 11909, 14979, 1942, 5987, 26723, 17, 2719, 3890, 26682, 1036, 1942, 4323, 1920, 13594, 1930, 3890, 24590, 3]}, "items": [{"id": "p_758", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_759", "content": "dyskinesias [SEP] )-exposed cynomolgus monkeys primed to exhibit levodopa-induced dyskinesias to evaluate the locomotor and dyskinetic effects on challenge w", "tokenized_content": [2, 3890, 26682, 1036, 3, 13, 17, 4616, 23836, 30351, 13057, 11909, 14979, 1942, 5987, 26723, 17, 2719, 3890, 26682, 1036, 1942, 4323, 1920, 13594, 1930, 3890, 24590, 2002, 2564, 1990, 3]}, "items": [{"id": "p_759", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_760", "content": "dyskinetic [SEP] ibit levodopa-induced dyskinesias to evaluate the locomotor and dyskinetic effects on challenge with four doses (from 0.03 to 1.0 mg/kg) o", "tokenized_content": [2, 3890, 24590, 2002, 3, 6180, 1932, 26723, 17, 2719, 3890, 26682, 1036, 1942, 4323, 1920, 13594, 1930, 3890, 24590, 2002, 2564, 1990, 6013, 1956, 3006, 5312, 12, 2037, 20, 18, 3]}, "items": [{"id": "p_760", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_761", "content": "A-86929 [SEP] ffects on challenge with four doses (from 0.03 to 1.0 mg/kg) of A-86929 ([-]-[5aR,11bS]-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-+ ++", "tokenized_content": [2, 43, 17, 5713, 11884, 1026, 3, 10735, 2284, 1990, 6013, 1956, 3006, 5312, 12, 2037, 20, 18, 5167, 1942, 21, 18, 20, 2786, 19, 3621, 13, 1927, 43, 17, 5713, 3]}, "items": [{"id": "p_761", "content": "A 86929 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 43, 5713, 11884, 1026, 3, 3]}]}
{"query": {"id": "q_762", "content": "[-]-[5aR,11bS]-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-+ ++azacyclopent-1- ena[c]phenathrene-9-10-diol [SEP]  challenge with four doses (from 0.03 to 1.0 mg/kg) of A-86929 ([-]-[5aR,11bS]-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-+ ++azacyclopent-1- ena[c]phenathrene-9-10-diol), a selective and full DA D1-like receptor agonist with an inte", "tokenized_content": [2, 37, 17, 39, 17, 37, 6871, 1005, 16, 28977, 1036, 39, 17, 24, 16, 25, 16, 6871, 16, 26, 16, 27, 16, 28977, 17, 7142, 5945, 2584, 1931, 17, 22, 3]}, "items": [{"id": "p_762", "content": "A 86929 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 43, 5713, 11884, 1026, 3, 3]}]}
{"query": {"id": "q_763", "content": "Levodopa [SEP] -like receptor agonist with an intermediate duration of action. Levodopa and the DA D2-like receptor agonist, LY-171555 ([4aR-trans]-4,4", "tokenized_content": [2, 26723, 3, 17, 3189, 3148, 7829, 1956, 1925, 6129, 4392, 1927, 4615, 18, 26723, 1930, 1920, 3692, 8631, 17, 3189, 3148, 7829, 16, 7518, 17, 16485, 7054, 1015, 12, 37, 3]}, "items": [{"id": "p_763", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_764", "content": "LY-171555 [SEP] ration of action. Levodopa and the DA D2-like receptor agonist, LY-171555 ([4aR-trans]-4,4a,5,6,7,8,8a,9-o-dihydro-5n-propyl-2H-pyrazo lo", "tokenized_content": [2, 7518, 17, 16485, 7054, 1015, 3, 12488, 1927, 4615, 18, 26723, 1930, 1920, 3692, 8631, 17, 3189, 3148, 7829, 16, 7518, 17, 16485, 7054, 1015, 12, 37, 6169, 1005, 17, 3]}, "items": [{"id": "p_764", "content": "4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 16, 6169, 16, 25, 16, 26, 16, 27, 16, 28, 16, 13396, 16, 29, 17, 5843, 5945, 2584, 1931, 17, 25, 17, 20299, 17, 5189, 17, 6487, 13642, 6012, 12, 23, 16, 24, 17, 49, 13, 9012, 8419, 3, 3]}]}
{"query": {"id": "q_765", "content": "[4aR-trans]-4,4a,5,6,7,8,8a,9-o-dihydro-5n-propyl-2H-pyrazo lo-3-4-quinoline hydrochloride [SEP] ction. Levodopa and the DA D2-like receptor agonist, LY-171555 ([4aR-trans]-4,4a,5,6,7,8,8a,9-o-dihydro-5n-propyl-2H-pyrazo lo-3-4-quinoline hydrochloride) were also used for comparison. Acute administration of A-86929", "tokenized_content": [2, 37, 6169, 1005, 17, 2127, 39, 17, 24, 16, 6169, 16, 25, 16, 26, 16, 27, 16, 28, 16, 13396, 16, 29, 17, 57, 17, 11842, 17, 25, 1022, 17, 3]}, "items": [{"id": "p_765", "content": "4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 16, 6169, 16, 25, 16, 26, 16, 27, 16, 28, 16, 13396, 16, 29, 17, 5843, 5945, 2584, 1931, 17, 25, 17, 20299, 17, 5189, 17, 6487, 13642, 6012, 12, 23, 16, 24, 17, 49, 13, 9012, 8419, 3, 3]}]}
{"query": {"id": "q_766", "content": "parkinsonism [SEP] ation of A-86929 was as efficacious in alleviating MPTP-induced parkinsonism as levodopa and LY-171555, but was less likely to reproduce the", "tokenized_content": [2, 26214, 3, 2019, 2001, 1927, 43, 17, 5713, 11884, 1026, 1982, 1966, 15860, 1922, 12054, 2287, 19043, 17, 2719, 26214, 1966, 26723, 1930, 7518, 17, 16485, 7054, 1015, 16, 2308, 3]}, "items": [{"id": "p_766", "content": "Parkinsonian Disorders [SEP] A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural i", "score": 1, "type": null, "tokenized_content": [2, 10124, 3122, 4414, 3, 43, 2210, 1927, 4414, 2154, 5961, 5761, 4842, 2285, 4378, 2007, 20152, 26682, 16, 3760, 20471, 31, 18388, 31, 1930, 17198, 51, 3]}]}
{"query": {"id": "q_767", "content": "convulsions [SEP] Deaths from local anesthetic-induced convulsions in mice.", "tokenized_content": [2, 4772, 19389, 3, 7601, 2037, 3076, 16111, 17, 2719, 4772, 19389, 1922, 2518, 18, 3]}, "items": [{"id": "p_767", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_768", "content": "convulsions [SEP] mice to evaluate the threat to life of local anesthetic-induced convulsions. The CD50 and LD50, respectively, were 57.7 and 58.7 mg/kg for ", "tokenized_content": [2, 4772, 19389, 3, 2518, 1942, 4323, 1920, 8521, 1942, 3308, 1927, 3076, 16111, 17, 2719, 4772, 19389, 18, 1920, 27344, 1008, 1930, 27746, 16, 2763, 16, 1985, 4786, 18, 27, 3]}, "items": [{"id": "p_768", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_769", "content": "bupivacaine [SEP] . The CD50 and LD50, respectively, were 57.7 and 58.7 mg/kg for bupivacaine, 111.0 and 133.1 mg/kg for lidocaine, and 243.4 and 266.5 mg/kg", "tokenized_content": [2, 25473, 3, 18, 1920, 27344, 1008, 1930, 27746, 16, 2763, 16, 1985, 4786, 18, 27, 1930, 4804, 18, 27, 2786, 19, 3621, 1958, 25473, 16, 10118, 18, 20, 1930, 12147, 3]}, "items": [{"id": "p_769", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_770", "content": "lidocaine [SEP]  57.7 and 58.7 mg/kg for bupivacaine, 111.0 and 133.1 mg/kg for lidocaine, and 243.4 and 266.5 mg/kg for chloroprocaine. When given intra", "tokenized_content": [2, 19567, 3, 4786, 18, 27, 1930, 4804, 18, 27, 2786, 19, 3621, 1958, 25473, 16, 10118, 18, 20, 1930, 12147, 18, 21, 2786, 19, 3621, 1958, 19567, 16, 1930, 20489, 3]}, "items": [{"id": "p_770", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_771", "content": "chloroprocaine [SEP] .0 and 133.1 mg/kg for lidocaine, and 243.4 and 266.5 mg/kg for chloroprocaine. When given intraperitoneally, bupivacaine thus was only about ", "tokenized_content": [2, 10107, 2216, 3375, 2053, 3, 18, 20, 1930, 12147, 18, 21, 2786, 19, 3621, 1958, 19567, 16, 1930, 20489, 18, 24, 1930, 22253, 18, 25, 2786, 19, 3621, 1958, 10107, 3]}, "items": [{"id": "p_771", "content": "chloroprocaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10107, 2216, 3375, 2053, 3, 3]}]}
{"query": {"id": "q_772", "content": "Convulsions [SEP] s toxic as lidocaine and four times as toxic as chloroprocaine. Convulsions always preceded death, except after precipitous cardiopulmonary", "tokenized_content": [2, 4772, 19389, 3, 61, 6161, 1966, 19567, 1930, 3006, 3586, 1966, 6161, 1966, 10107, 2216, 3375, 2053, 18, 4772, 19389, 6789, 16757, 3539, 16, 5574, 2256, 9637, 2080, 17749, 3]}, "items": [{"id": "p_772", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_773", "content": "cardiopulmonary arrest [SEP] ne. Convulsions always preceded death, except after precipitous cardiopulmonary arrest from extreme doses. A CD50 dose of local anesthetic (causing co", "tokenized_content": [2, 17749, 8048, 3, 2069, 18, 4772, 19389, 6789, 16757, 3539, 16, 5574, 2256, 9637, 2080, 17749, 8048, 2037, 9848, 5312, 18, 43, 27344, 1008, 3253, 1927, 3076, 16111, 12, 7538, 3]}, "items": [{"id": "p_773", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_774", "content": "seizures [SEP] ulsions in 50% of mice) was fatal in 90% of bupivacaine-induced seizures, in 57% of the chloroprocaine group, and in 6% of the lidocaine", "tokenized_content": [2, 10060, 3, 3570, 12924, 2101, 1922, 2761, 9, 1927, 2518, 13, 1982, 11990, 1922, 3865, 9, 1927, 25473, 17, 2719, 10060, 16, 1922, 4786, 9, 1927, 1920, 10107, 2216, 3375, 3]}, "items": [{"id": "p_774", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_775", "content": "absence seizures [SEP] Myoclonic, atonic, and absence seizures following institution of carbamazepine therapy in children.", "tokenized_content": [2, 3905, 10060, 3, 15924, 2223, 3490, 16, 2019, 3490, 16, 1930, 3905, 10060, 2894, 5115, 1927, 30315, 3181, 1922, 3069, 18, 3]}, "items": [{"id": "p_775", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_776", "content": "carbamazepine [SEP] yoclonic, atonic, and absence seizures following institution of carbamazepine therapy in children.", "tokenized_content": [2, 30315, 3, 7419, 2223, 3490, 16, 2019, 3490, 16, 1930, 3905, 10060, 2894, 5115, 1927, 30315, 3181, 1922, 3069, 18, 3]}, "items": [{"id": "p_776", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_777", "content": "carbamazepine [SEP] Five children, aged 3 to 11 years, treated with carbamazepine for epilepsy, had an acute aberrant reaction characterized by t", "tokenized_content": [2, 30315, 3, 3628, 3069, 16, 5177, 23, 1942, 2513, 2739, 16, 2868, 1956, 30315, 1958, 9741, 16, 2430, 1925, 3939, 9801, 3227, 4378, 2007, 62, 3]}, "items": [{"id": "p_777", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_778", "content": "epilepsy [SEP] ve children, aged 3 to 11 years, treated with carbamazepine for epilepsy, had an acute aberrant reaction characterized by the onset of m", "tokenized_content": [2, 9741, 3, 3428, 3069, 16, 5177, 23, 1942, 2513, 2739, 16, 2868, 1956, 30315, 1958, 9741, 16, 2430, 1925, 3939, 9801, 3227, 4378, 2007, 1920, 4727, 1927, 55, 3]}, "items": [{"id": "p_778", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_779", "content": "seizures [SEP] nset of myoclonic, atypical absence and/or atonic (minor motor) seizures within a few days. When the carbamazepine was discontinued, two", "tokenized_content": [2, 10060, 3, 28686, 1031, 1927, 15924, 2223, 3490, 16, 10834, 3905, 1930, 19, 2014, 2019, 3490, 12, 5857, 4842, 13, 10060, 2651, 43, 3855, 3000, 18, 2469, 1920, 30315, 1982, 3]}, "items": [{"id": "p_779", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_780", "content": "ceroid lipofuscinosis [SEP] he child in whom the seizures persisted was later found to have ceroid lipofuscinosis. The other children are doing well on other anticonvulsants.", "tokenized_content": [2, 6580, 2642, 13739, 7801, 11096, 1937, 3, 2234, 2748, 1922, 8566, 1920, 10060, 14583, 1982, 3690, 2435, 1942, 2162, 6580, 2642, 13739, 7801, 11096, 1937, 18, 1920, 2303, 3069, 2032, 3]}, "items": [{"id": "p_780", "content": "Neuronal Ceroid-Lipofuscinoses [SEP] A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid mater", "score": 1, "type": null, "tokenized_content": [2, 5121, 6580, 2642, 17, 13739, 7801, 11096, 1918, 3, 43, 2210, 1927, 4010, 11128, 3902, 4378, 2007, 4776, 4858, 1927, 5728, 7494, 3025, 18578, 17, 3189, 4486, 3126, 3]}]}
{"query": {"id": "q_781", "content": "Naloxone [SEP] Naloxone reversal of hypotension due to captopril overdose.", "tokenized_content": [2, 21926, 3, 21926, 12393, 1927, 16453, 2810, 1942, 7502, 24863, 21090, 18, 3]}, "items": [{"id": "p_781", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_782", "content": "hypotension [SEP] Naloxone reversal of hypotension due to captopril overdose.", "tokenized_content": [2, 16453, 3, 21926, 12393, 1927, 16453, 2810, 1942, 7502, 24863, 21090, 18, 3]}, "items": [{"id": "p_782", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_783", "content": "captopril [SEP] Naloxone reversal of hypotension due to captopril overdose.", "tokenized_content": [2, 7502, 24863, 3, 21926, 12393, 1927, 16453, 2810, 1942, 7502, 24863, 21090, 18, 3]}, "items": [{"id": "p_783", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_784", "content": "overdose [SEP] Naloxone reversal of hypotension due to captopril overdose.", "tokenized_content": [2, 21090, 3, 21926, 12393, 1927, 16453, 2810, 1942, 7502, 24863, 21090, 18, 3]}, "items": [{"id": "p_784", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_785", "content": "captopril [SEP] The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors may be media", "tokenized_content": [2, 7502, 24863, 3, 1920, 12173, 2564, 1927, 7502, 24863, 1930, 2303, 10814, 17, 15025, 4113, 4472, 2278, 1998, 4996, 3]}, "items": [{"id": "p_785", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_786", "content": "angiotensin-converting enzyme inhibitors [SEP] The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors may be mediated by the endogenous opioid system. The opioid ant", "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 1920, 12173, 2564, 1927, 7502, 24863, 1930, 2303, 10814, 17, 15025, 4113, 4472, 2278, 1998, 3434, 2007, 1920, 5355, 9384, 2433, 18, 1920, 9384, 3]}, "items": [{"id": "p_786", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_787", "content": "naloxone [SEP] mediated by the endogenous opioid system. The opioid antagonist naloxone has been shown to block or reverse the hypotensive actions of c", "tokenized_content": [2, 21926, 3, 3434, 2007, 1920, 5355, 9384, 2433, 18, 1920, 9384, 8151, 21926, 2258, 2252, 2522, 1942, 3367, 2014, 5267, 1920, 12201, 3766, 7728, 1927, 45, 3]}, "items": [{"id": "p_787", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_788", "content": "hypotensive [SEP] ioid antagonist naloxone has been shown to block or reverse the hypotensive actions of captopril. We report a case of an intentional captop", "tokenized_content": [2, 12201, 3766, 3, 21509, 1960, 8151, 21926, 2258, 2252, 2522, 1942, 3367, 2014, 5267, 1920, 12201, 3766, 7728, 1927, 7502, 24863, 18, 2038, 3809, 43, 3087, 1927, 1925, 23309, 7502, 3]}, "items": [{"id": "p_788", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_789", "content": "overdose [SEP] ions of captopril. We report a case of an intentional captopril overdose, manifested by marked hypotension, that resolved promptly with ", "tokenized_content": [2, 21090, 3, 6982, 1927, 7502, 24863, 18, 2038, 3809, 43, 3087, 1927, 1925, 23309, 7502, 24863, 21090, 16, 16687, 2007, 4961, 16453, 16, 1988, 8397, 29594, 1956, 3]}, "items": [{"id": "p_789", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_790", "content": "hypotension [SEP] case of an intentional captopril overdose, manifested by marked hypotension, that resolved promptly with the administration of naloxone. To", "tokenized_content": [2, 16453, 3, 3087, 1927, 1925, 23309, 7502, 24863, 21090, 16, 16687, 2007, 4961, 16453, 16, 1988, 8397, 29594, 1956, 1920, 4183, 1927, 21926, 18, 1942, 3]}, "items": [{"id": "p_790", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_791", "content": "Carbamazepine [SEP] Carbamazepine-induced cardiac dysfunction. Characterization of two distinct c", "tokenized_content": [2, 30315, 3, 30315, 17, 2719, 4435, 5273, 18, 7285, 1927, 2288, 4493, 45, 3]}, "items": [{"id": "p_791", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_792", "content": "cardiac dysfunction [SEP] Carbamazepine-induced cardiac dysfunction. Characterization of two distinct clinical syndromes.", "tokenized_content": [2, 4435, 5273, 3, 30315, 17, 2719, 4435, 5273, 18, 7285, 1927, 2288, 4493, 2535, 12688, 18, 3]}, "items": [{"id": "p_792", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_793", "content": "bradycardia [SEP] A patient with sinus bradycardia and atrioventricular block, induced by carbamazepine, prompted ", "tokenized_content": [2, 26192, 3, 43, 2774, 1956, 9414, 26192, 1930, 28355, 3367, 16, 2719, 2007, 30315, 16, 15376, 3]}, "items": [{"id": "p_793", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_794", "content": "atrioventricular block [SEP] A patient with sinus bradycardia and atrioventricular block, induced by carbamazepine, prompted an extensive literature rev", "tokenized_content": [2, 28355, 3367, 3, 43, 2774, 1956, 9414, 26192, 1930, 28355, 3367, 16, 2719, 2007, 30315, 16, 15376, 1925, 6475, 4431, 5197, 3]}, "items": [{"id": "p_794", "content": "Atrioventricular Block [SEP] Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduc", "score": 1, "type": null, "tokenized_content": [2, 28355, 3367, 3, 5761, 21896, 12382, 2037, 4003, 26500, 1019, 1942, 4003, 21008, 18, 2781, 3367, 2112, 2667, 7083, 2014, 5796, 6923, 21896, 3164, 3]}]}
{"query": {"id": "q_795", "content": "carbamazepine [SEP] t with sinus bradycardia and atrioventricular block, induced by carbamazepine, prompted an extensive literature review of all previously repo", "tokenized_content": [2, 30315, 3, 62, 1956, 9414, 26192, 1930, 28355, 3367, 16, 2719, 2007, 30315, 16, 15376, 1925, 6475, 4431, 3043, 1927, 2136, 3024, 3073, 1037, 3]}, "items": [{"id": "p_795", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_796", "content": "cardiac dysfunction [SEP]  of these cases, two distinct forms of carbamazepine-associated cardiac dysfunction emerged. One patient group developed sinus tachycardias in the ", "tokenized_content": [2, 4435, 5273, 3, 1927, 2144, 2919, 16, 2288, 4493, 4952, 1927, 30315, 17, 2458, 4435, 5273, 9287, 18, 2340, 2774, 2210, 3530, 9414, 17397, 1036, 1922, 1920, 3]}, "items": [{"id": "p_796", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_797", "content": "sinus tachycardias [SEP] ciated cardiac dysfunction emerged. One patient group developed sinus tachycardias in the setting of a massive carbamazepine overdose. The second ", "tokenized_content": [2, 9414, 17397, 1036, 3, 24748, 2013, 4435, 5273, 9287, 18, 2340, 2774, 2210, 3530, 9414, 17397, 1036, 1922, 1920, 4308, 1927, 43, 12944, 30315, 21090, 18, 1920, 2812, 3]}, "items": [{"id": "p_797", "content": "Tachycardia, Sinus [SEP] Simple rapid heartbeats caused by rapid discharge of impulses from the SINOATRIAL NODE, usually between 100 and 180 beats/min in", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 9414, 3, 5288, 4052, 4003, 5873, 5149, 4189, 2007, 4052, 7695, 1927, 21896, 1036, 2037, 1920, 3132, 6952, 17075, 6267, 16, 5394, 2192, 2813, 1930, 8585, 19380, 19, 2360, 1922, 3]}]}
{"query": {"id": "q_798", "content": "overdose [SEP] ed sinus tachycardias in the setting of a massive carbamazepine overdose. The second group consisted almost exclusively of elderly women", "tokenized_content": [2, 21090, 3, 3347, 9414, 17397, 1036, 1922, 1920, 4308, 1927, 43, 12944, 30315, 21090, 18, 1920, 2812, 2210, 6994, 5365, 9326, 1927, 7354, 3089, 3]}, "items": [{"id": "p_798", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_799", "content": "bradyarrhythmias [SEP] ely of elderly women who developed potentially life-threatening bradyarrhythmias or atrioventricular conduction delay, associated with either th", "tokenized_content": [2, 20152, 23246, 15519, 3, 2349, 1012, 1927, 7354, 3089, 2746, 3530, 5063, 3308, 17, 13281, 20152, 23246, 15519, 2014, 28355, 12382, 4989, 16, 2458, 1956, 3108, 1913, 3]}, "items": [{"id": "p_799", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_800", "content": "atrioventricular conduction delay [SEP]  who developed potentially life-threatening bradyarrhythmias or atrioventricular conduction delay, associated with either therapeutic or modestly elevated carbam", "tokenized_content": [2, 28355, 12382, 4989, 3, 2746, 3530, 5063, 3308, 17, 13281, 20152, 23246, 15519, 2014, 28355, 12382, 4989, 16, 2458, 1956, 3108, 4272, 2014, 21626, 4664, 17742, 3]}, "items": [{"id": "p_800", "content": "Atrioventricular Block [SEP] Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduc", "score": 1, "type": null, "tokenized_content": [2, 28355, 3367, 3, 5761, 21896, 12382, 2037, 4003, 26500, 1019, 1942, 4003, 21008, 18, 2781, 3367, 2112, 2667, 7083, 2014, 5796, 6923, 21896, 3164, 3]}]}
{"query": {"id": "q_801", "content": "psychiatric [SEP] mazepine is widely used in the treatment of many neurologic and psychiatric conditions, the recognition of the latter syndrome has importan", "tokenized_content": [2, 7652, 3, 14476, 12184, 1977, 5673, 2251, 1922, 1920, 2311, 1927, 3086, 14314, 1930, 7652, 2961, 16, 1920, 5708, 1927, 1920, 6296, 4741, 2258, 2582, 1928, 3]}, "items": [{"id": "p_801", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_802", "content": "NMDA [SEP] Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-i", "tokenized_content": [2, 10976, 3, 16922, 20221, 3434, 2007, 10976, 4086, 1922, 1920, 8756, 2674, 21206, 2112, 8480, 25107, 17, 51, 3]}, "items": [{"id": "p_802", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_803", "content": "haloperidol [SEP] iated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.", "tokenized_content": [2, 25107, 3, 21006, 1919, 2007, 10976, 4086, 1922, 1920, 8756, 2674, 21206, 2112, 8480, 25107, 17, 2719, 4233, 9431, 1012, 18, 3]}, "items": [{"id": "p_803", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_804", "content": "catalepsy [SEP] ors in the inferior colliculus can modulate haloperidol-induced catalepsy.", "tokenized_content": [2, 4233, 9431, 1012, 3, 14957, 1922, 1920, 8756, 2674, 21206, 2112, 8480, 25107, 17, 2719, 4233, 9431, 1012, 18, 3]}, "items": [{"id": "p_804", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_805", "content": "amino acid [SEP] at activation of the IC by electrical stimulation or excitatory amino acid microinjection causes freezing, escape-like behavior, and immob", "tokenized_content": [2, 3835, 2687, 3, 2019, 2936, 1927, 1920, 3996, 2007, 8287, 4177, 2014, 11237, 3835, 2687, 24283, 5092, 13627, 16, 11781, 17, 3189, 3379, 16, 1930, 8504, 3]}, "items": [{"id": "p_805", "content": "Amino Acids [SEP] Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits", "score": 1, "type": null, "tokenized_content": [2, 3835, 4576, 3, 6805, 4300, 1988, 4933, 5531, 1925, 3835, 12, 17, 15410, 13, 1930, 43, 9943, 12, 17, 20729, 13, 2210, 18, 7639, 4595, 17, 3835, 4576, 2032, 1920, 6991, 3]}]}
{"query": {"id": "q_806", "content": "catalepsy [SEP] e of excitatory amino acid-mediated mechanisms in the IC on the catalepsy induced by the dopamine receptor blocker haloperidol administer", "tokenized_content": [2, 4233, 9431, 1012, 3, 47, 1927, 11237, 3835, 2687, 17, 3434, 3531, 1922, 1920, 3996, 1990, 1920, 4233, 9431, 1012, 2719, 2007, 1920, 7964, 3148, 14580, 25107, 15487, 3]}, "items": [{"id": "p_806", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_807", "content": "dopamine [SEP] d-mediated mechanisms in the IC on the catalepsy induced by the dopamine receptor blocker haloperidol administered systemically (1 or 0.", "tokenized_content": [2, 7964, 3, 46, 17, 3434, 3531, 1922, 1920, 3996, 1990, 1920, 4233, 9431, 1012, 2719, 2007, 1920, 7964, 3148, 14580, 25107, 5254, 22791, 12, 21, 2014, 20, 18, 3]}, "items": [{"id": "p_807", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_808", "content": "haloperidol [SEP] he IC on the catalepsy induced by the dopamine receptor blocker haloperidol administered systemically (1 or 0.5 mg/kg) in rats. Haloperidol", "tokenized_content": [2, 25107, 3, 2234, 3996, 1990, 1920, 4233, 9431, 1012, 2719, 2007, 1920, 7964, 3148, 14580, 25107, 5254, 22791, 12, 21, 2014, 20, 18, 25, 2786, 19, 3621, 13, 1922, 3615, 3]}, "items": [{"id": "p_808", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_809", "content": "Haloperidol [SEP] haloperidol administered systemically (1 or 0.5 mg/kg) in rats. Haloperidol-induced catalepsy was challenged with prior intracollicular mic", "tokenized_content": [2, 25107, 3, 25107, 5254, 22791, 12, 21, 2014, 20, 18, 25, 2786, 19, 3621, 13, 1922, 3615, 18, 25107, 17, 2719, 4233, 9431, 1012, 1982, 11784, 1956, 3432, 4245, 2201, 3]}, "items": [{"id": "p_809", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_810", "content": "glutamate [SEP] sy was challenged with prior intracollicular microinjections of glutamate NMDA receptor antagonists, MK-801 (15 or 30 mmol/0.5 microl) an", "tokenized_content": [2, 7627, 3, 7930, 1982, 11784, 1956, 3432, 4245, 2201, 4588, 24283, 1036, 1927, 7627, 10976, 3148, 10515, 16, 10539, 17, 23858, 12, 2461, 2014, 2627, 6397, 19, 20, 18, 25, 3]}, "items": [{"id": "p_810", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_811", "content": "NMDA [SEP] llenged with prior intracollicular microinjections of glutamate NMDA receptor antagonists, MK-801 (15 or 30 mmol/0.5 microl) and AP7", "tokenized_content": [2, 10976, 3, 10748, 26464, 1007, 1956, 3432, 4245, 2201, 4588, 24283, 1036, 1927, 7627, 10976, 3148, 10515, 16, 10539, 17, 23858, 12, 2461, 2014, 2627, 6397, 19, 20, 18, 25, 3]}, "items": [{"id": "p_811", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_812", "content": "MK-801 [SEP] licular microinjections of glutamate NMDA receptor antagonists, MK-801 (15 or 30 mmol/0.5 microl) and AP7 (10 or 20 nmol/0.5 microl), ", "tokenized_content": [2, 10539, 17, 23858, 3, 10247, 2168, 24283, 1036, 1927, 7627, 10976, 3148, 10515, 16, 10539, 17, 23858, 12, 2461, 2014, 2627, 6397, 19, 20, 18, 25, 16262, 13, 1930, 2100, 3]}, "items": [{"id": "p_812", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_813", "content": "AP7 [SEP] MDA receptor antagonists, MK-801 (15 or 30 mmol/0.5 microl) and AP7 (10 or 20 nmol/0.5 microl), or of the NMDA receptor agonist N-m", "tokenized_content": [2, 2100, 1027, 3, 7887, 3148, 10515, 16, 10539, 17, 23858, 12, 2461, 2014, 2627, 6397, 19, 20, 18, 25, 16262, 13, 1930, 2100, 1027, 12, 2119, 2014, 2036, 11087, 19, 3]}, "items": [{"id": "p_813", "content": "2-amino-7-phosphonoheptanoic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 3835, 17, 27, 17, 8078, 11873, 4116, 25958, 11873, 1935, 2687, 3, 3]}]}
{"query": {"id": "q_814", "content": "N-methyl-d-aspartate [SEP] AP7 (10 or 20 nmol/0.5 microl), or of the NMDA receptor agonist N-methyl-d-aspartate (NMDA, 20 or 30 nmol/0.5 microl). The results showed that intra", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 2100, 1027, 12, 2119, 2014, 2036, 11087, 19, 20, 18, 25, 16262, 13, 16, 2014, 1927, 1920, 10976, 3148, 7829, 56, 17, 3]}, "items": [{"id": "p_814", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_815", "content": "glutamate [SEP] Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of", "tokenized_content": [2, 7627, 3, 18447, 8405, 7627, 27, 3148, 8856, 13112, 4842, 3601, 1922, 11880, 3130, 1927, 3]}, "items": [{"id": "p_815", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_816", "content": "Parkinson's disease [SEP] 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 27, 3148, 8856, 13112, 4842, 3601, 1922, 11880, 3130, 1927, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_816", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_817", "content": "glutamate [SEP] Metabotropic glutamate (mGlu) receptors modulate synaptic transmission in the central ", "tokenized_content": [2, 7627, 3, 18447, 8405, 7627, 12, 27821, 13, 4086, 8480, 6251, 5303, 1922, 1920, 4101, 3]}, "items": [{"id": "p_817", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_818", "content": "Parkinson's disease [SEP] sent promising therapeutic targets for symptomatic treatment of Parkinson's disease (PD). Among the eight mGlu receptor subtypes, mGlu7 receptor is", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 8437, 6842, 4272, 4845, 1958, 9371, 2311, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 18, 2706, 1920, 5066, 27821, 3148, 8160, 16, 27821, 1027, 3]}, "items": [{"id": "p_818", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_819", "content": "PD [SEP] eutic targets for symptomatic treatment of Parkinson's disease (PD). Among the eight mGlu receptor subtypes, mGlu7 receptor is pro", "tokenized_content": [2, 3203, 3, 24048, 1935, 4845, 1958, 9371, 2311, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 18, 2706, 1920, 5066, 27821, 3148, 8160, 16, 27821, 1027, 3148, 1977, 1965, 3]}, "items": [{"id": "p_819", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_820", "content": "N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride [SEP] or function in animal models of PD is not known. The effects of N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082), the first selective allosteric activator of mGlu7 rec", "tokenized_content": [2, 56, 16, 56, 11, 17, 17239, 4389, 10806, 6752, 1963, 2516, 17, 21, 16, 22, 17, 21121, 1021, 11842, 11600, 2261, 3, 2014, 2347, 1922, 4027, 3130, 1927, 3203, 1977, 3]}, "items": [{"id": "p_820", "content": "N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 16, 56, 11, 17, 17239, 4389, 10806, 6752, 1963, 2516, 17, 21, 16, 22, 17, 21121, 1021, 11842, 11600, 2261, 3, 3]}]}
{"query": {"id": "q_821", "content": "AMN082 [SEP] effects of N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082), the first selective allosteric activator of mGlu7 receptors, ", "tokenized_content": [2, 14701, 13895, 1028, 3, 2564, 1927, 56, 16, 56, 11, 17, 17239, 4389, 10806, 6752, 1963, 2516, 17, 21, 16, 22, 17, 21121, 1021, 11842, 11600, 2261, 12, 14701, 13895, 3]}, "items": [{"id": "p_821", "content": "N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 16, 56, 11, 17, 17239, 4389, 10806, 6752, 1963, 2516, 17, 21, 16, 22, 17, 21121, 1021, 11842, 11600, 2261, 3, 3]}]}
{"query": {"id": "q_822", "content": "haloperidol [SEP] rastriatal administration (0.1 and 0.5 nmol) of AMN082 reverses haloperidol-induced catalepsy in rats. AMN082 (2.5 and 5 mg/kg) reduces apo", "tokenized_content": [2, 25107, 3, 6520, 1997, 21195, 4183, 12, 20, 18, 21, 1930, 20, 18, 25, 11087, 13, 1927, 14701, 13895, 1028, 28817, 25107, 17, 2719, 4233, 9431, 1012, 1922, 3615, 18, 3]}, "items": [{"id": "p_822", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_823", "content": "catalepsy [SEP] ation (0.1 and 0.5 nmol) of AMN082 reverses haloperidol-induced catalepsy in rats. AMN082 (2.5 and 5 mg/kg) reduces apomorphine-induced r", "tokenized_content": [2, 4233, 9431, 1012, 3, 2019, 2001, 12, 20, 18, 21, 1930, 20, 18, 25, 11087, 13, 1927, 14701, 13895, 1028, 28817, 25107, 17, 2719, 4233, 9431, 1012, 1922, 3615, 18, 3]}, "items": [{"id": "p_823", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_824", "content": "apomorphine [SEP] dol-induced catalepsy in rats. AMN082 (2.5 and 5 mg/kg) reduces apomorphine-induced rotations in unilateral 6-hydroxydopamine (6-OHDA)-lesi", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 17837, 17, 2719, 4233, 9431, 1012, 1922, 3615, 18, 14701, 13895, 1028, 12, 22, 18, 25, 1930, 25, 2786, 19, 3621, 13, 7268, 11466, 3]}, "items": [{"id": "p_824", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_825", "content": "6-hydroxydopamine [SEP] nd 5 mg/kg) reduces apomorphine-induced rotations in unilateral 6-hydroxydopamine (6-OHDA)-lesioned rats. In a more complex task commonly used to", "tokenized_content": [2, 26, 17, 8275, 22389, 4302, 25157, 3, 8026, 25, 2786, 19, 3621, 13, 7268, 11466, 12492, 11119, 7969, 2912, 17, 2719, 22737, 1922, 12059, 26, 17, 8275, 22389, 4302, 25157, 3]}, "items": [{"id": "p_825", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_826", "content": "6-OHDA [SEP]  apomorphine-induced rotations in unilateral 6-hydroxydopamine (6-OHDA)-lesioned rats. In a more complex task commonly used to evaluat", "tokenized_content": [2, 26, 17, 25737, 3, 11466, 12492, 11119, 7969, 2912, 17, 2719, 22737, 1922, 12059, 26, 17, 8275, 22389, 4302, 25157, 12, 26, 17, 25737, 13, 17, 24187, 3615, 18, 1922, 3]}, "items": [{"id": "p_826", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_827", "content": "akinetic [SEP] ed rats. In a more complex task commonly used to evaluate major akinetic symptoms of PD patients, 5 mg/kg AMN082 reverses the increased ", "tokenized_content": [2, 26162, 3023, 3, 3347, 3615, 18, 1922, 43, 2253, 2796, 3909, 5384, 2251, 1942, 4323, 3044, 26162, 3023, 3601, 1927, 3203, 2132, 16, 25, 2786, 19, 3621, 14701, 13895, 1028, 3]}, "items": [{"id": "p_827", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_828", "content": "dopamine [SEP] g) reduces apomorphine-induced rotations in unilateral 6-hydroxydopamine (6-OHDA)-lesioned rats. In a more complex task commonly used to", "tokenized_content": [2, 7964, 3, 49, 13, 7268, 11466, 12492, 11119, 7969, 2912, 17, 2719, 22737, 1922, 12059, 26, 17, 8275, 22389, 4302, 25157, 12, 26, 17, 25737, 13, 17, 24187, 3615, 18, 3]}, "items": [{"id": "p_828", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_829", "content": "Nimodipine [SEP] Nimodipine prevents memory impairment caused by nitroglycerin-induced hypo", "tokenized_content": [2, 17709, 26584, 3, 17709, 26584, 10299, 4525, 6159, 4189, 2007, 8686, 14966, 1921, 17, 2719, 14395, 3]}, "items": [{"id": "p_829", "content": "Nimodipine [SEP] A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lower", "score": 1, "type": null, "tokenized_content": [2, 17709, 26584, 3, 43, 5016, 4999, 9847, 1005, 1956, 15069, 16221, 2455, 18, 2176, 2258, 4961, 16221, 4333, 2287, 2564, 1930, 2826, 3]}]}
{"query": {"id": "q_830", "content": "memory impairment [SEP] Nimodipine prevents memory impairment caused by nitroglycerin-induced hypotension in adult mice.", "tokenized_content": [2, 4525, 6159, 3, 17709, 26584, 10299, 4525, 6159, 4189, 2007, 8686, 14966, 1921, 17, 2719, 16453, 1922, 4160, 2518, 18, 3]}, "items": [{"id": "p_830", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_831", "content": "nitroglycerin [SEP] Nimodipine prevents memory impairment caused by nitroglycerin-induced hypotension in adult mice.", "tokenized_content": [2, 8686, 14966, 1921, 3, 17709, 26584, 10299, 4525, 6159, 4189, 2007, 8686, 14966, 1921, 17, 2719, 16453, 1922, 4160, 2518, 18, 3]}, "items": [{"id": "p_831", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_832", "content": "hypotension [SEP] pine prevents memory impairment caused by nitroglycerin-induced hypotension in adult mice.", "tokenized_content": [2, 16453, 3, 17541, 10299, 4525, 6159, 4189, 2007, 8686, 14966, 1921, 17, 2719, 16453, 1922, 4160, 2518, 18, 3]}, "items": [{"id": "p_832", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_833", "content": "Hypotension [SEP] BACKGROUND: Hypotension and a resultant decrease in cerebral blood flow have been impli", "tokenized_content": [2, 16453, 3, 3872, 30, 16453, 1930, 43, 13484, 3714, 1922, 6329, 2877, 3426, 2162, 2252, 6313, 1033, 3]}, "items": [{"id": "p_833", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_834", "content": "cognitive dysfunction [SEP]  cerebral blood flow have been implicated in the development of cognitive dysfunction. We tested the hypothesis that nimodipine (NIMO) administered a", "tokenized_content": [2, 4328, 5273, 3, 6329, 2877, 3426, 2162, 2252, 6835, 1922, 1920, 2740, 1927, 4328, 5273, 18, 2038, 3620, 1920, 4676, 1988, 17709, 26584, 12, 17709, 1037, 13, 5254, 43, 3]}, "items": [{"id": "p_834", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_835", "content": "nimodipine [SEP] lopment of cognitive dysfunction. We tested the hypothesis that nimodipine (NIMO) administered at the onset of nitroglycerin (NTG)-induced", "tokenized_content": [2, 17709, 26584, 3, 3004, 17922, 1939, 1927, 4328, 5273, 18, 2038, 3620, 1920, 4676, 1988, 17709, 26584, 12, 17709, 1037, 13, 5254, 2019, 1920, 4727, 1927, 8686, 14966, 1921, 12, 3]}, "items": [{"id": "p_835", "content": "Nimodipine [SEP] A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lower", "score": 1, "type": null, "tokenized_content": [2, 17709, 26584, 3, 43, 5016, 4999, 9847, 1005, 1956, 15069, 16221, 2455, 18, 2176, 2258, 4961, 16221, 4333, 2287, 2564, 1930, 2826, 3]}]}
{"query": {"id": "q_836", "content": "NIMO [SEP] ognitive dysfunction. We tested the hypothesis that nimodipine (NIMO) administered at the onset of nitroglycerin (NTG)-induced hypot", "tokenized_content": [2, 17709, 1037, 3, 17395, 8635, 2185, 5273, 18, 2038, 3620, 1920, 4676, 1988, 17709, 26584, 12, 17709, 1037, 13, 5254, 2019, 1920, 4727, 1927, 8686, 14966, 1921, 12, 30161, 13, 3]}, "items": [{"id": "p_836", "content": "Nimodipine [SEP] A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lower", "score": 1, "type": null, "tokenized_content": [2, 17709, 26584, 3, 43, 5016, 4999, 9847, 1005, 1956, 15069, 16221, 2455, 18, 2176, 2258, 4961, 16221, 4333, 2287, 2564, 1930, 2826, 3]}]}
{"query": {"id": "q_837", "content": "nitroglycerin [SEP]  hypothesis that nimodipine (NIMO) administered at the onset of nitroglycerin (NTG)-induced hypotension would preserve long-term associative ", "tokenized_content": [2, 8686, 14966, 1921, 3, 4676, 1988, 17709, 26584, 12, 17709, 1037, 13, 5254, 2019, 1920, 4727, 1927, 8686, 14966, 1921, 12, 30161, 13, 17, 2719, 16453, 2962, 15873, 2815, 17, 3]}, "items": [{"id": "p_837", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_838", "content": "NTG [SEP] t nimodipine (NIMO) administered at the onset of nitroglycerin (NTG)-induced hypotension would preserve long-term associative memor", "tokenized_content": [2, 30161, 3, 62, 17709, 26584, 12, 17709, 1037, 13, 5254, 2019, 1920, 4727, 1927, 8686, 14966, 1921, 12, 30161, 13, 17, 2719, 16453, 2962, 15873, 2815, 17, 2576, 20216, 2562, 3]}, "items": [{"id": "p_838", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_839", "content": "hypotension [SEP] (NIMO) administered at the onset of nitroglycerin (NTG)-induced hypotension would preserve long-term associative memory. METHODS: The passi", "tokenized_content": [2, 16453, 3, 12, 17709, 1037, 13, 5254, 2019, 1920, 4727, 1927, 8686, 14966, 1921, 12, 30161, 13, 17, 2719, 16453, 2962, 15873, 2815, 17, 2576, 20216, 4525, 18, 2860, 30, 3]}, "items": [{"id": "p_839", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_840", "content": "hypotensive [SEP]  similar training latencies (17.0 +/- 4.6 s). Mice subjected to hypotensive episodes showed a significant decrease in latency time (178 +/-", "tokenized_content": [2, 12201, 3766, 3, 2551, 4096, 18604, 12, 2752, 18, 20, 15, 19, 17, 24, 18, 26, 61, 13, 18, 2518, 6243, 1942, 12201, 3766, 9232, 2594, 43, 2228, 3714, 1922, 3]}, "items": [{"id": "p_840", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_841", "content": "calcium [SEP] ffect of NIMO may have been attributable to the preservation of calcium homeostasis during hypotension, because there were no differenc", "tokenized_content": [2, 5016, 3, 10735, 2089, 1927, 17709, 1037, 2278, 2162, 2252, 11081, 1942, 1920, 12698, 1927, 5016, 7622, 2409, 16453, 16, 2882, 2276, 1985, 2239, 2129, 2135, 3]}, "items": [{"id": "p_841", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_842", "content": "haemopericardium [SEP] Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of", "tokenized_content": [2, 7105, 3556, 6102, 8544, 2457, 3, 11990, 7105, 3556, 6102, 8544, 2457, 1930, 8375, 23352, 2810, 1942, 3216, 2835, 1927, 3]}, "items": [{"id": "p_842", "content": "Pericardial Effusion [SEP] Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associa", "score": 1, "type": null, "tokenized_content": [2, 22188, 17673, 3, 5466, 4858, 2651, 1920, 10796, 26872, 18, 19965, 17673, 1036, 2032, 2458, 1956, 22188, 3902, 18, 3243, 3556, 6102, 8544, 2457, 1977, 2293, 1019, 3]}]}
{"query": {"id": "q_843", "content": "gastrointestinal haemorrhage [SEP] Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin.", "tokenized_content": [2, 8375, 23352, 3, 11990, 7105, 3556, 6102, 8544, 2457, 1930, 8375, 23352, 2810, 1942, 3216, 2835, 1927, 17829, 18642, 17574, 1956, 16170, 18, 3]}, "items": [{"id": "p_843", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_844", "content": "warfarin [SEP] haemorrhage due to possible interaction of cranberry juice with warfarin.", "tokenized_content": [2, 16170, 3, 23352, 2810, 1942, 3216, 2835, 1927, 17829, 18642, 17574, 1956, 16170, 18, 3]}, "items": [{"id": "p_844", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_845", "content": "haemorrhage [SEP] We report a case of fatal internal haemorrhage in an elderly man who consumed only cranberry juice for two wee", "tokenized_content": [2, 23352, 3, 2038, 3809, 43, 3087, 1927, 11990, 4495, 23352, 1922, 1925, 7354, 2323, 2746, 10848, 2444, 17829, 18642, 17574, 1958, 2288, 2038, 1021, 3]}, "items": [{"id": "p_845", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_846", "content": "warfarin [SEP] berry juice for two weeks while maintaining his usual dosage of warfarin. We propose that naturally occurring compounds such as flavonoi", "tokenized_content": [2, 16170, 3, 28195, 17574, 1958, 2288, 3625, 2679, 8231, 4167, 10616, 9998, 1927, 16170, 18, 2038, 8040, 1988, 10414, 6966, 4300, 2427, 1966, 12094, 26822, 3]}, "items": [{"id": "p_846", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_847", "content": "flavonoids [SEP] warfarin. We propose that naturally occurring compounds such as flavonoids, which are present in fruit juices, may increase the potency of", "tokenized_content": [2, 16192, 3, 16170, 18, 2038, 8040, 1988, 10414, 6966, 4300, 2427, 1966, 16192, 16, 2154, 2032, 2481, 1922, 9021, 17574, 1036, 16, 2278, 2760, 1920, 10397, 1927, 3]}, "items": [{"id": "p_847", "content": "Flavonoids [SEP] A group of phenyl benzopyrans named for having structures like FLAVONES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16192, 3, 43, 2210, 1927, 7971, 19225, 18425, 2075, 10314, 1958, 4537, 4061, 3189, 12094, 1918, 18, 3]}]}
{"query": {"id": "q_848", "content": "Isoproterenol [SEP] Isoproterenol induces primary loss of dystrophin in rat hearts: correlation w", "tokenized_content": [2, 23743, 3, 23743, 6387, 3065, 3257, 1927, 23678, 1922, 3067, 11333, 30, 3670, 65, 3]}, "items": [{"id": "p_848", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_849", "content": "myocardial injury [SEP] uces primary loss of dystrophin in rat hearts: correlation with myocardial injury.", "tokenized_content": [2, 6497, 4047, 3, 8577, 1918, 3065, 3257, 1927, 23678, 1922, 3067, 11333, 30, 3670, 1956, 6497, 4047, 18, 3]}, "items": [{"id": "p_849", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_850", "content": "isoproterenol [SEP] The mechanism of isoproterenol-induced myocardial damage is unknown, but a mismatch of oxygen ", "tokenized_content": [2, 23743, 3, 1920, 2856, 1927, 23743, 17, 2719, 6497, 4293, 1977, 5435, 16, 2308, 43, 10265, 1927, 4612, 3]}, "items": [{"id": "p_850", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_851", "content": "myocardial damage [SEP] The mechanism of isoproterenol-induced myocardial damage is unknown, but a mismatch of oxygen supply vs. demand followin", "tokenized_content": [2, 6497, 4293, 3, 1920, 2856, 1927, 23743, 17, 2719, 6497, 4293, 1977, 5435, 16, 2308, 43, 10265, 1927, 4612, 9042, 3201, 18, 9749, 2396, 1921, 3]}, "items": [{"id": "p_851", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_852", "content": "oxygen [SEP] terenol-induced myocardial damage is unknown, but a mismatch of oxygen supply vs. demand following coronary hypotension and myocardial", "tokenized_content": [2, 4612, 3, 6005, 9356, 17, 2719, 6497, 4293, 1977, 5435, 16, 2308, 43, 10265, 1927, 4612, 9042, 3201, 18, 9749, 2894, 5846, 16453, 1930, 6497, 3]}, "items": [{"id": "p_852", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_853", "content": "hypotension [SEP] , but a mismatch of oxygen supply vs. demand following coronary hypotension and myocardial hyperactivity is the best explanation for the co", "tokenized_content": [2, 16453, 3, 16, 2308, 43, 10265, 1927, 4612, 9042, 3201, 18, 9749, 2894, 5846, 16453, 1930, 6497, 15534, 1977, 1920, 4534, 8042, 1958, 1920, 2081, 3]}, "items": [{"id": "p_853", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_854", "content": "myocardial hyperactivity [SEP]  of oxygen supply vs. demand following coronary hypotension and myocardial hyperactivity is the best explanation for the complex morphological alteratio", "tokenized_content": [2, 6497, 15534, 3, 1927, 4612, 9042, 3201, 18, 9749, 2894, 5846, 16453, 1930, 6497, 15534, 1977, 1920, 4534, 8042, 1958, 1920, 2796, 7060, 4238, 1968, 1037, 3]}, "items": [{"id": "p_854", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_855", "content": "ischaemic injury [SEP] nd the cytoskeleton in cardiomyocyte. These changes, related to ischaemic injury, explain the severe alterations in the structural integrity of ", "tokenized_content": [2, 19855, 4047, 3, 8026, 1920, 11612, 1922, 18357, 18, 2144, 2840, 16, 2712, 1942, 19855, 4047, 16, 5895, 1920, 4010, 5996, 1922, 1920, 4346, 7996, 1927, 3]}, "items": [{"id": "p_855", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_856", "content": "fat [SEP] High fat diet-fed obese rats are highly sensitive to doxorubicin-induced", "tokenized_content": [2, 3777, 3, 2149, 3777, 3986, 17, 5788, 7379, 3615, 2032, 3626, 4532, 1942, 12377, 17, 2719, 3]}, "items": [{"id": "p_856", "content": "Dietary Fats [SEP] Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts", "score": 1, "type": null, "tokenized_content": [2, 6096, 27751, 3, 27751, 2481, 1922, 3959, 16, 4369, 1922, 4027, 4461, 2427, 1966, 12040, 16, 12040, 4461, 16, 20883, 16, 6101, 5182, 18, 2611, 2032, 2481, 1922, 2826, 6222, 3]}]}
{"query": {"id": "q_857", "content": "obese [SEP] High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity", "tokenized_content": [2, 7379, 3, 2149, 3777, 3986, 17, 5788, 7379, 3615, 2032, 3626, 4532, 1942, 12377, 17, 2719, 30490, 3]}, "items": [{"id": "p_857", "content": "Obesity [SEP] A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS i", "score": 1, "type": null, "tokenized_content": [2, 5379, 3, 43, 3642, 1956, 3362, 3388, 1988, 1977, 28655, 3538, 1920, 9630, 2014, 13321, 3388, 16, 5394, 2810, 1942, 4858, 1927, 5799, 27751, 51, 3]}]}
{"query": {"id": "q_858", "content": "doxorubicin [SEP] High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.", "tokenized_content": [2, 12377, 3, 2149, 3777, 3986, 17, 5788, 7379, 3615, 2032, 3626, 4532, 1942, 12377, 17, 2719, 30490, 18, 3]}, "items": [{"id": "p_858", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_859", "content": "cardiotoxicity [SEP] diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.", "tokenized_content": [2, 30490, 3, 3986, 17, 5788, 7379, 3615, 2032, 3626, 4532, 1942, 12377, 17, 2719, 30490, 18, 3]}, "items": [{"id": "p_859", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_860", "content": "doxorubicin [SEP] Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity ", "tokenized_content": [2, 12377, 3, 3868, 16, 5318, 2007, 12377, 12, 25622, 7898, 13, 1977, 3892, 2810, 1942, 3308, 13281, 30490, 3]}, "items": [{"id": "p_860", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_861", "content": "Adriamycin [SEP] Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients ", "tokenized_content": [2, 25622, 7898, 3, 3868, 16, 5318, 2007, 12377, 12, 25622, 7898, 13, 1977, 3892, 2810, 1942, 3308, 13281, 30490, 1922, 2132, 3]}, "items": [{"id": "p_861", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_862", "content": "cardiotoxicity [SEP]  by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown tha", "tokenized_content": [2, 30490, 3, 2007, 12377, 12, 25622, 7898, 13, 1977, 3892, 2810, 1942, 3308, 13281, 30490, 1922, 2132, 2409, 1930, 2753, 20512, 18, 3998, 16, 2038, 2162, 2522, 21513, 3]}, "items": [{"id": "p_862", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_863", "content": "triglycerides [SEP] ection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and ", "tokenized_content": [2, 13631, 3, 7495, 2001, 1977, 7936, 2007, 3261, 4435, 5163, 3071, 1930, 13631, 1930, 2502, 4435, 5934, 17, 2687, 6638, 16, 4498, 4271, 16, 1930, 3]}, "items": [{"id": "p_863", "content": "Triglycerides [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13631, 3, 3]}]}
{"query": {"id": "q_864", "content": "ATP [SEP] s and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current st", "tokenized_content": [2, 4498, 3, 61, 1930, 13631, 1930, 2502, 4435, 5934, 17, 2687, 6638, 16, 4498, 4271, 16, 1930, 7675, 10108, 19, 8919, 3374, 18, 1922, 1920, 3214, 1955, 3]}, "items": [{"id": "p_864", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_865", "content": "fat [SEP] ardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 path", "tokenized_content": [2, 3777, 3, 2245, 7408, 1948, 5163, 3071, 1930, 13631, 1930, 2502, 4435, 5934, 17, 2687, 6638, 16, 4498, 4271, 16, 1930, 7675, 10108, 19, 8919, 2450, 3]}, "items": [{"id": "p_865", "content": "Dietary Fats [SEP] Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts", "score": 1, "type": null, "tokenized_content": [2, 6096, 27751, 3, 27751, 2481, 1922, 3959, 16, 4369, 1922, 4027, 4461, 2427, 1966, 12040, 16, 12040, 4461, 16, 20883, 16, 6101, 5182, 18, 2611, 2032, 2481, 1922, 2826, 6222, 3]}]}
{"query": {"id": "q_866", "content": "obesity [SEP]  intervention by feeding 40% high fat diet (HFD), which induces obesity in male Sprague-Dawley rats (250-275 g), sensitizes to doxorubi", "tokenized_content": [2, 5379, 3, 3280, 2007, 6788, 3040, 9, 2149, 3777, 3986, 12, 11922, 13, 16, 2154, 6387, 5379, 1922, 4005, 15684, 17, 15798, 3615, 12, 6330, 17, 18821, 49, 13, 16, 3]}, "items": [{"id": "p_866", "content": "Obesity [SEP] A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS i", "score": 1, "type": null, "tokenized_content": [2, 5379, 3, 43, 3642, 1956, 3362, 3388, 1988, 1977, 28655, 3538, 1920, 9630, 2014, 13321, 3388, 16, 5394, 2810, 1942, 4858, 1927, 5799, 27751, 51, 3]}]}
{"query": {"id": "q_867", "content": "cardiac dysfunction [SEP] day 43 of the HFD feeding regimen led to higher cardiotoxicity, cardiac dysfunction, lipid peroxidation, and 80% mortality in the obese (OB) rats i", "tokenized_content": [2, 4435, 5273, 3, 3007, 3941, 1927, 1920, 11922, 6788, 8607, 4866, 1942, 2580, 30490, 16, 4435, 5273, 16, 4486, 14214, 16, 1930, 3729, 9, 3885, 1922, 1920, 7379, 12, 2384, 3]}, "items": [{"id": "p_867", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_868", "content": "obese [SEP] rdiac dysfunction, lipid peroxidation, and 80% mortality in the obese (OB) rats in the absence of any significant renal or hepatic to", "tokenized_content": [2, 7379, 3, 8695, 2126, 1030, 5273, 16, 4486, 14214, 16, 1930, 3729, 9, 3885, 1922, 1920, 7379, 12, 2384, 13, 3615, 1922, 1920, 3905, 1927, 2967, 2228, 4604, 2014, 6095, 3]}, "items": [{"id": "p_868", "content": "Obesity [SEP] A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS i", "score": 1, "type": null, "tokenized_content": [2, 5379, 3, 43, 3642, 1956, 3362, 3388, 1988, 1977, 28655, 3538, 1920, 9630, 2014, 13321, 3388, 16, 5394, 2810, 1942, 4858, 1927, 5799, 27751, 51, 3]}]}
{"query": {"id": "q_869", "content": "OB [SEP] ysfunction, lipid peroxidation, and 80% mortality in the obese (OB) rats in the absence of any significant renal or hepatic toxici", "tokenized_content": [2, 2384, 3, 24018, 4916, 16, 4486, 14214, 16, 1930, 3729, 9, 3885, 1922, 1920, 7379, 12, 2384, 13, 3615, 1922, 1920, 3905, 1927, 2967, 2228, 4604, 2014, 6095, 6161, 1033, 3]}, "items": [{"id": "p_869", "content": "Obesity [SEP] A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS i", "score": 1, "type": null, "tokenized_content": [2, 5379, 3, 43, 3642, 1956, 3362, 3388, 1988, 1977, 28655, 3538, 1920, 9630, 2014, 13321, 3388, 16, 5394, 2810, 1942, 4858, 1927, 5799, 27751, 51, 3]}]}
{"query": {"id": "q_870", "content": "hepatic toxicity [SEP]  the obese (OB) rats in the absence of any significant renal or hepatic toxicity. Doxorubicin toxicokinetics studies revealed no change in accum", "tokenized_content": [2, 6095, 5532, 3, 1920, 7379, 12, 2384, 13, 3615, 1922, 1920, 3905, 1927, 2967, 2228, 4604, 2014, 6095, 5532, 18, 12377, 6161, 28731, 1036, 2351, 3404, 2239, 3185, 1922, 4020, 3]}, "items": [{"id": "p_870", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_871", "content": "Doxorubicin [SEP] ts in the absence of any significant renal or hepatic toxicity. Doxorubicin toxicokinetics studies revealed no change in accumulation of do", "tokenized_content": [2, 12377, 3, 4894, 1922, 1920, 3905, 1927, 2967, 2228, 4604, 2014, 6095, 5532, 18, 12377, 6161, 28731, 1036, 2351, 3404, 2239, 3185, 1922, 4858, 1927, 2608, 3]}, "items": [{"id": "p_871", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_872", "content": "doxorubicinol [SEP] s studies revealed no change in accumulation of doxorubicin and doxorubicinol (toxic metabolite) in the normal diet-fed (ND) and OB hearts. M", "tokenized_content": [2, 12377, 1945, 3, 61, 2351, 3404, 2239, 3185, 1922, 4858, 1927, 12377, 1930, 12377, 1945, 12, 6161, 9483, 13, 1922, 1920, 2791, 3986, 17, 5788, 12, 8026, 13, 1930, 2384, 3]}, "items": [{"id": "p_872", "content": "adriamycinol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25622, 7898, 1945, 3, 3]}]}
{"query": {"id": "q_873", "content": "AMP [SEP] 0.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels a", "tokenized_content": [2, 3681, 3, 20, 18, 22, 15, 19, 17, 2513, 18, 28, 11087, 19, 2360, 19, 49, 4003, 1922, 2384, 13, 16, 12, 25, 13, 3261, 4596, 3681, 17, 4595, 1028, 3]}, "items": [{"id": "p_873", "content": "Adenosine Monophosphate [SEP] Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10125, 21363, 3, 15643, 5489, 3165, 2340, 5413, 2210, 9603, 2828, 1942, 1920, 9523, 11804, 1922, 1920, 22, 11, 17, 16, 23, 11, 17, 16, 2014, 25, 11, 17, 3507, 18, 3]}]}
{"query": {"id": "q_874", "content": "ADP [SEP] (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration. Decreased cardiac eryth", "tokenized_content": [2, 9828, 3, 12, 26, 13, 5713, 9, 7086, 1922, 4435, 4498, 2428, 7936, 2007, 3261, 4498, 19, 9828, 3400, 2256, 12377, 4183, 18, 3261, 4435, 6549, 3]}, "items": [{"id": "p_874", "content": "Adenosine Diphosphate [SEP] Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at ", "score": 1, "type": null, "tokenized_content": [2, 10125, 23266, 3, 10125, 25, 11, 17, 12, 5083, 8535, 2432, 23266, 13, 18, 1925, 15643, 5489, 3165, 2288, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 2019, 3]}]}
{"query": {"id": "q_875", "content": "atrioventricular block [SEP] Complete atrioventricular block secondary to lithium therapy.", "tokenized_content": [2, 28355, 3367, 3, 4080, 28355, 3367, 4067, 1942, 14330, 3181, 18, 3]}, "items": [{"id": "p_875", "content": "Atrioventricular Block [SEP] Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduc", "score": 1, "type": null, "tokenized_content": [2, 28355, 3367, 3, 5761, 21896, 12382, 2037, 4003, 26500, 1019, 1942, 4003, 21008, 18, 2781, 3367, 2112, 2667, 7083, 2014, 5796, 6923, 21896, 3164, 3]}]}
{"query": {"id": "q_876", "content": "lithium [SEP] Complete atrioventricular block secondary to lithium therapy.", "tokenized_content": [2, 14330, 3, 4080, 28355, 3367, 4067, 1942, 14330, 3181, 18, 3]}, "items": [{"id": "p_876", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_877", "content": "Sinus node dysfunction [SEP] Sinus node dysfunction has been reported most frequently among the adverse cardiovascu", "tokenized_content": [2, 9414, 6267, 5273, 3, 9414, 6267, 5273, 2258, 2252, 2568, 2501, 5467, 2706, 1920, 5246, 21129, 10916, 18021, 3]}, "items": [{"id": "p_877", "content": "Sick Sinus Syndrome [SEP] A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impuls", "score": 1, "type": null, "tokenized_content": [2, 11258, 9414, 4741, 3, 43, 2625, 4189, 2007, 24199, 2712, 1942, 1920, 3132, 6952, 17075, 6267, 2710, 21896, 4841, 12, 4435, 9414, 8048, 13, 1930, 15396, 3]}]}
{"query": {"id": "q_878", "content": "lithium [SEP] ted most frequently among the adverse cardiovascular effects of lithium. In the present case, complete atrioventricular (AV) block with", "tokenized_content": [2, 14330, 3, 26080, 2501, 5467, 2706, 1920, 5246, 5321, 2564, 1927, 14330, 18, 1922, 1920, 2481, 3087, 16, 4080, 28355, 12, 2781, 13, 3367, 1956, 3]}, "items": [{"id": "p_878", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_879", "content": "atrioventricular (AV) block [SEP] ardiovascular effects of lithium. In the present case, complete atrioventricular (AV) block with syncopal attacks developed secondary to lithium therapy, n", "tokenized_content": [2, 28355, 12, 2781, 13, 3367, 3, 2245, 7408, 4901, 2564, 1927, 14330, 18, 1922, 1920, 2481, 3087, 16, 4080, 28355, 12, 2781, 13, 3367, 1956, 2540, 2972, 1923, 15413, 3530, 3]}, "items": [{"id": "p_879", "content": "Atrioventricular Block [SEP] Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduc", "score": 1, "type": null, "tokenized_content": [2, 28355, 3367, 3, 5761, 21896, 12382, 2037, 4003, 26500, 1019, 1942, 4003, 21008, 18, 2781, 3367, 2112, 2667, 7083, 2014, 5796, 6923, 21896, 3164, 3]}]}
{"query": {"id": "q_880", "content": "syncopal attacks [SEP]  In the present case, complete atrioventricular (AV) block with syncopal attacks developed secondary to lithium therapy, necessitating permanent", "tokenized_content": [2, 2540, 2972, 1923, 15413, 3, 1922, 1920, 2481, 3087, 16, 4080, 28355, 12, 2781, 13, 3367, 1956, 2540, 2972, 1923, 15413, 3530, 4067, 1942, 14330, 3181, 16, 16593, 2287, 11047, 3]}, "items": [{"id": "p_880", "content": "Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync", "score": 1, "type": null, "tokenized_content": [2, 26742, 3, 43, 6809, 3257, 1927, 16897, 1930, 17198, 11020, 4189, 2007, 9597, 2877, 3426, 1942, 1920, 3068, 12, 51, 18, 47, 18, 16, 3068, 7716, 13, 18, 2244, 2304, 1030, 3]}]}
{"query": {"id": "q_881", "content": "Lithium [SEP] er or within the therapeutic range during the syncopal attacks. Lithium should be used with extreme caution, especially in patients wit", "tokenized_content": [2, 14330, 3, 2668, 2014, 2651, 1920, 4272, 3109, 2409, 1920, 2540, 2972, 1923, 15413, 18, 14330, 3066, 1998, 2251, 1956, 9848, 12838, 16, 4369, 1922, 2132, 16086, 3]}, "items": [{"id": "p_881", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_882", "content": "Neuroleptic malignant syndrome [SEP] Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 20325, 17920, 6558, 4741, 2719, 2007, 14912, 29375, 15726, 1990, 1920, 2812, 3007, 1927, 2311, 18, 3]}, "items": [{"id": "p_882", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_883", "content": "ziprasidone [SEP] Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.", "tokenized_content": [2, 14912, 29375, 15726, 3, 20325, 17920, 6558, 4741, 2719, 2007, 14912, 29375, 15726, 1990, 1920, 2812, 3007, 1927, 2311, 18, 3]}, "items": [{"id": "p_883", "content": "ziprasidone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14912, 29375, 15726, 3, 3]}]}
{"query": {"id": "q_884", "content": "Neuroleptic malignant syndrome [SEP] Neuroleptic malignant syndrome (NMS) is the rarest and most serious of the neuroleptic-induced", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 20325, 17920, 6558, 4741, 12, 25088, 13, 1977, 1920, 5844, 2156, 1930, 2501, 7433, 1927, 1920, 20325, 17920, 17, 2719, 3]}, "items": [{"id": "p_884", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_885", "content": "NMS [SEP] Neuroleptic malignant syndrome (NMS) is the rarest and most serious of the neuroleptic-induced move", "tokenized_content": [2, 25088, 3, 20325, 17920, 6558, 4741, 12, 25088, 13, 1977, 1920, 5844, 2156, 1930, 2501, 7433, 1927, 1920, 20325, 17920, 17, 2719, 6532, 3]}, "items": [{"id": "p_885", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_886", "content": "movement disorders [SEP] (NMS) is the rarest and most serious of the neuroleptic-induced movement disorders. We describe a case of neuroleptic malignant syndrome (NMS) ass", "tokenized_content": [2, 5829, 4414, 3, 12, 25088, 13, 1977, 1920, 5844, 2156, 1930, 2501, 7433, 1927, 1920, 20325, 17920, 17, 2719, 5829, 4414, 18, 2038, 5993, 43, 3087, 1927, 20325, 17920, 6558, 3]}, "items": [{"id": "p_886", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_887", "content": "neuroleptic malignant syndrome [SEP] e neuroleptic-induced movement disorders. We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone. Although conventi", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 47, 20325, 17920, 17, 2719, 5829, 4414, 18, 2038, 5993, 43, 3087, 1927, 20325, 17920, 6558, 4741, 12, 25088, 13, 2458, 1956, 1920, 2485, 1927, 3]}, "items": [{"id": "p_887", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_888", "content": "ziprasidone [SEP] neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone. Although conventional neuroleptics are more frequently associa", "tokenized_content": [2, 14912, 29375, 15726, 3, 20325, 17920, 6558, 4741, 12, 25088, 13, 2458, 1956, 1920, 2485, 1927, 14912, 29375, 15726, 18, 2876, 5552, 20325, 17920, 1036, 2032, 2253, 5467, 2293, 1019, 3]}, "items": [{"id": "p_888", "content": "ziprasidone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14912, 29375, 15726, 3, 3]}]}
{"query": {"id": "q_889", "content": "schizophrenia [SEP] be a cause. The patient is a 24-year-old male with a history of schizophrenia who developed signs and symptoms of NMS after 2 days of treatme", "tokenized_content": [2, 7899, 3, 1998, 43, 3936, 18, 1920, 2774, 1977, 43, 2686, 17, 2476, 17, 4156, 4005, 1956, 43, 4403, 1927, 7899, 2746, 3530, 6879, 1930, 3601, 1927, 25088, 2256, 22, 3]}, "items": [{"id": "p_889", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_890", "content": "mangiferin [SEP] Role of mangiferin on biochemical alterations and antioxidant status in isoprotere", "tokenized_content": [2, 22383, 3236, 1921, 3, 2770, 1927, 22383, 3236, 1921, 1990, 6503, 5996, 1930, 7335, 3642, 1922, 10301, 23362, 1021, 3]}, "items": [{"id": "p_890", "content": "mangiferin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22383, 3236, 1921, 3, 3]}]}
{"query": {"id": "q_891", "content": "isoproterenol [SEP] mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 23743, 3, 22383, 3236, 1921, 1990, 6503, 5996, 1930, 7335, 3642, 1922, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_891", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_892", "content": "myocardial infarction [SEP] cal alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 6497, 8358, 3, 2570, 5996, 1930, 7335, 3642, 1922, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_892", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_893", "content": "mangiferin [SEP] The current study dealt with the protective role of mangiferin, a polyphenol from Mangifera indica Linn. (Anacardiaceae), on i", "tokenized_content": [2, 22383, 3236, 1921, 3, 1920, 3214, 2161, 10370, 1031, 1956, 1920, 6337, 2770, 1927, 22383, 3236, 1921, 16, 43, 27964, 2037, 22383, 19582, 29338, 8128, 1022, 18, 12, 7381, 15339, 3]}, "items": [{"id": "p_893", "content": "mangiferin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22383, 3236, 1921, 3, 3]}]}
{"query": {"id": "q_894", "content": "polyphenol [SEP] e current study dealt with the protective role of mangiferin, a polyphenol from Mangifera indica Linn. (Anacardiaceae), on isoproterenol (", "tokenized_content": [2, 27964, 3, 47, 3214, 2161, 10370, 1031, 1956, 1920, 6337, 2770, 1927, 22383, 3236, 1921, 16, 43, 27964, 2037, 22383, 19582, 29338, 8128, 1022, 18, 12, 7381, 15339, 7408, 9914, 3]}, "items": [{"id": "p_894", "content": "Polyphenols [SEP] A large class of organic compounds having more than one PHENOL group.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20212, 3, 43, 3103, 2921, 1927, 6805, 4300, 4537, 2253, 2254, 2340, 12658, 2210, 18, 3]}]}
{"query": {"id": "q_895", "content": "isoproterenol [SEP] n, a polyphenol from Mangifera indica Linn. (Anacardiaceae), on isoproterenol (ISPH)-induced myocardial infarction (MI) in rats through its a", "tokenized_content": [2, 23743, 3, 56, 16, 43, 27964, 2037, 22383, 19582, 29338, 8128, 1022, 18, 12, 7381, 15339, 7408, 9914, 13, 16, 1990, 23743, 12, 1977, 2102, 13, 17, 2719, 6497, 8358, 3]}, "items": [{"id": "p_895", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_896", "content": "ISPH [SEP]  from Mangifera indica Linn. (Anacardiaceae), on isoproterenol (ISPH)-induced myocardial infarction (MI) in rats through its antioxi", "tokenized_content": [2, 1977, 2102, 3, 2037, 22383, 19582, 29338, 8128, 1022, 18, 12, 7381, 15339, 7408, 9914, 13, 16, 1990, 23743, 12, 1977, 2102, 13, 17, 2719, 6497, 8358, 12, 6519, 13, 3]}, "items": [{"id": "p_896", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_897", "content": "myocardial infarction [SEP] a indica Linn. (Anacardiaceae), on isoproterenol (ISPH)-induced myocardial infarction (MI) in rats through its antioxidative mechanism. Subcutaneous ", "tokenized_content": [2, 6497, 8358, 3, 43, 29338, 8128, 1022, 18, 12, 7381, 15339, 7408, 9914, 13, 16, 1990, 23743, 12, 1977, 2102, 13, 17, 2719, 6497, 8358, 12, 6519, 13, 1922, 3615, 3]}, "items": [{"id": "p_897", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_898", "content": "MI [SEP] iaceae), on isoproterenol (ISPH)-induced myocardial infarction (MI) in rats through its antioxidative mechanism. Subcutaneous inje", "tokenized_content": [2, 6519, 3, 20320, 5376, 1021, 13, 16, 1990, 23743, 12, 1977, 2102, 13, 17, 2719, 6497, 8358, 12, 6519, 13, 1922, 3615, 2596, 2496, 27375, 2856, 18, 8634, 2831, 1021, 3]}, "items": [{"id": "p_898", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_899", "content": "myocardial damage [SEP] dy weight in 1 ml saline) to rats for 2 consecutive days caused myocardial damage in rat heart, which was determined by the increased activity of", "tokenized_content": [2, 6497, 4293, 3, 6433, 3388, 1922, 21, 2646, 5977, 13, 1942, 3615, 1958, 22, 7351, 3000, 4189, 6497, 4293, 1922, 3067, 4003, 16, 2154, 1982, 3180, 2007, 1920, 2502, 2455, 3]}, "items": [{"id": "p_899", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_900", "content": "lactate [SEP]  heart, which was determined by the increased activity of serum lactate dehydrogenase (LDH) and creatine phosphokinase isoenzymes (CK-M", "tokenized_content": [2, 9456, 3, 4003, 16, 2154, 1982, 3180, 2007, 1920, 2502, 2455, 1927, 3256, 9456, 9294, 12, 12713, 13, 1930, 17784, 8078, 25545, 4911, 26897, 12, 6394, 17, 55, 3]}, "items": [{"id": "p_900", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_901", "content": "creatine [SEP] the increased activity of serum lactate dehydrogenase (LDH) and creatine phosphokinase isoenzymes (CK-MB), increased uric acid level and", "tokenized_content": [2, 17784, 3, 1920, 2502, 2455, 1927, 3256, 9456, 9294, 12, 12713, 13, 1930, 17784, 8078, 25545, 4911, 26897, 12, 6394, 17, 5667, 13, 16, 2502, 17607, 2687, 2237, 1930, 3]}, "items": [{"id": "p_901", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_902", "content": "uric acid [SEP]  (LDH) and creatine phosphokinase isoenzymes (CK-MB), increased uric acid level and reduced plasma iron binding capacity. The protective ", "tokenized_content": [2, 17607, 2687, 3, 12, 12713, 13, 1930, 17784, 8078, 25545, 4911, 26897, 12, 6394, 17, 5667, 13, 16, 2502, 17607, 2687, 2237, 1930, 3028, 3582, 5680, 2743, 4796, 18, 1920, 3]}, "items": [{"id": "p_902", "content": "Uric Acid [SEP] An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product o", "score": 1, "type": null, "tokenized_content": [2, 17607, 2687, 3, 1925, 6638, 4863, 16, 3454, 26059, 10488, 16, 1927, 20004, 1034, 17687, 1036, 2427, 1966, 26059, 1930, 5918, 24943, 18, 2176, 1977, 1920, 3948, 6638, 4863, 57, 3]}]}
{"query": {"id": "q_903", "content": "iron [SEP] soenzymes (CK-MB), increased uric acid level and reduced plasma iron binding capacity. The protective role of mangiferin was analyze", "tokenized_content": [2, 5680, 3, 2577, 26897, 12, 6394, 17, 5667, 13, 16, 2502, 17607, 2687, 2237, 1930, 3028, 3582, 5680, 2743, 4796, 18, 1920, 6337, 2770, 1927, 22383, 3236, 1921, 1982, 7125, 3]}, "items": [{"id": "p_903", "content": "Iron [SEP] A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBI", "score": 1, "type": null, "tokenized_content": [2, 5680, 3, 43, 16790, 6149, 1956, 11241, 17530, 2650, 16, 11241, 2529, 3179, 16, 1930, 11241, 3388, 4288, 18, 5140, 18, 2176, 1977, 1925, 4415, 18690, 1927, 3243, 6292, 1033, 3]}]}
{"query": {"id": "q_904", "content": "triphenyl tetrazolium chloride [SEP] ing capacity. The protective role of mangiferin was analyzed by triphenyl tetrazolium chloride (TTC) test used for macroscopic enzyme mapping assay of the isc", "tokenized_content": [2, 14051, 8033, 24844, 9140, 3, 30393, 4796, 18, 1920, 6337, 2770, 1927, 22383, 3236, 1921, 1982, 3265, 2007, 14051, 8033, 24844, 9140, 12, 19914, 13, 2648, 2251, 1958, 16171, 4113, 3]}, "items": [{"id": "p_904", "content": "triphenyltetrazolium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14051, 8033, 28959, 17396, 3, 3]}]}
{"query": {"id": "q_905", "content": "TTC [SEP] e of mangiferin was analyzed by triphenyl tetrazolium chloride (TTC) test used for macroscopic enzyme mapping assay of the ischemic", "tokenized_content": [2, 19914, 3, 47, 1927, 22383, 3236, 1921, 1982, 3265, 2007, 14051, 8033, 24844, 9140, 12, 19914, 13, 2648, 2251, 1958, 16171, 4113, 7084, 3381, 1927, 1920, 7427, 3]}, "items": [{"id": "p_905", "content": "triphenyltetrazolium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14051, 8033, 28959, 17396, 3, 3]}]}
{"query": {"id": "q_906", "content": "ischemic myocardium [SEP] ide (TTC) test used for macroscopic enzyme mapping assay of the ischemic myocardium. The heart tissue antioxidant enzymes such as superoxide dismut", "tokenized_content": [2, 7427, 13295, 3, 9043, 12, 19914, 13, 2648, 2251, 1958, 16171, 4113, 7084, 3381, 1927, 1920, 7427, 13295, 18, 1920, 4003, 2960, 7335, 5038, 2427, 1966, 10738, 16208, 3]}, "items": [{"id": "p_906", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_907", "content": "superoxide [SEP] chemic myocardium. The heart tissue antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione transf", "tokenized_content": [2, 10738, 3, 2975, 1935, 13295, 18, 1920, 4003, 2960, 7335, 5038, 2427, 1966, 10738, 16679, 16, 14508, 16, 9153, 9433, 16, 9153, 3806, 3]}, "items": [{"id": "p_907", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_908", "content": "glutathione [SEP] sue antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase and glutathione reductase a", "tokenized_content": [2, 9153, 3, 2020, 1021, 7335, 5038, 2427, 1966, 10738, 16679, 16, 14508, 16, 9153, 9433, 16, 9153, 13763, 1930, 9153, 11386, 43, 3]}, "items": [{"id": "p_908", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_909", "content": "Vitamin C [SEP] se activities, non-enzymic antioxidants such as cerruloplasmin, Vitamin C, Vitamin E and glutathione levels were altered in MI rats. Upon", "tokenized_content": [2, 6111, 45, 3, 2058, 4209, 16, 2447, 17, 3209, 1935, 14651, 2427, 1966, 6580, 3176, 6012, 15403, 1921, 16, 6111, 45, 16, 6111, 47, 1930, 9153, 2428, 1985, 5520, 1922, 3]}, "items": [{"id": "p_909", "content": "Ascorbic Acid [SEP] A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essent", "score": 1, "type": null, "tokenized_content": [2, 18265, 2687, 3, 43, 3798, 5056, 3547, 2712, 1942, 3817, 18, 2176, 1977, 2435, 10414, 1922, 24117, 12953, 1930, 3086, 14206, 18, 18265, 2687, 1977, 1925, 4023, 1939, 3]}]}
{"query": {"id": "q_910", "content": "Vitamin E [SEP] es, non-enzymic antioxidants such as cerruloplasmin, Vitamin C, Vitamin E and glutathione levels were altered in MI rats. Upon pretreatme", "tokenized_content": [2, 6111, 47, 3, 2376, 16, 2447, 17, 3209, 1935, 14651, 2427, 1966, 6580, 3176, 6012, 15403, 1921, 16, 6111, 45, 16, 6111, 47, 1930, 9153, 2428, 1985, 5520, 1922, 6519, 3]}, "items": [{"id": "p_910", "content": "Vitamin E [SEP] A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydr", "score": 1, "type": null, "tokenized_content": [2, 6111, 47, 3, 43, 13459, 5690, 2684, 1958, 2136, 21432, 1036, 1930, 21682, 18935, 9356, 1036, 1988, 5987, 4595, 17, 21432, 2455, 18, 2007, 25130, 1927, 1920, 14223, 9698, 3]}]}
{"query": {"id": "q_911", "content": "dimethyl sulphoxide [SEP] ent with mangiferin (100 mg/kg body weight suspended in 2 ml of dimethyl sulphoxide) given intraperitoneally for 28 days to MI rats protected the a", "tokenized_content": [2, 9780, 13528, 6211, 3, 8496, 1956, 22383, 3236, 1921, 12, 2813, 2786, 19, 3621, 3362, 3388, 11095, 1922, 22, 2646, 1927, 9780, 13528, 6211, 13, 3258, 17245, 1958, 3158, 3000, 3]}, "items": [{"id": "p_911", "content": "Dimethyl Sulfoxide [SEP] A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membran", "score": 1, "type": null, "tokenized_content": [2, 9780, 20139, 3, 43, 3626, 5676, 6805, 5875, 16, 1988, 1977, 2251, 5673, 1966, 43, 4399, 7596, 18, 2882, 1927, 2496, 3682, 1942, 21224, 3933, 3033, 1928, 3]}]}
{"query": {"id": "q_912", "content": "cardiac damage [SEP] t potential, which regulated the tissues defense system against cardiac damage.", "tokenized_content": [2, 4435, 4293, 3, 62, 2889, 16, 2154, 4335, 1920, 3878, 9720, 2433, 3316, 4435, 4293, 18, 3]}, "items": [{"id": "p_912", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_913", "content": "Remifentanil [SEP] Remifentanil pretreatment reduces myoclonus after etomidate.", "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 2500, 10528, 4905, 16692, 9111, 7268, 15924, 2223, 1916, 1957, 2256, 2140, 1947, 21550, 18, 3]}, "items": [{"id": "p_913", "content": "remifentanil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 3]}]}
{"query": {"id": "q_914", "content": "myoclonus [SEP] Remifentanil pretreatment reduces myoclonus after etomidate.", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 2500, 10528, 4905, 16692, 9111, 7268, 15924, 2223, 1916, 1957, 2256, 2140, 1947, 21550, 18, 3]}, "items": [{"id": "p_914", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_915", "content": "etomidate [SEP] Remifentanil pretreatment reduces myoclonus after etomidate.", "tokenized_content": [2, 2140, 1947, 21550, 3, 2500, 10528, 4905, 16692, 9111, 7268, 15924, 2223, 1916, 1957, 2256, 2140, 1947, 21550, 18, 3]}, "items": [{"id": "p_915", "content": "Etomidate [SEP] Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It ha", "score": 1, "type": null, "tokenized_content": [2, 2140, 1947, 21550, 3, 16045, 10533, 16111, 1930, 25810, 3153, 1956, 5082, 2495, 1990, 2877, 20374, 16, 10198, 16, 2014, 1920, 5321, 2433, 18, 2176, 2118, 3]}]}
{"query": {"id": "q_916", "content": "remifentanil [SEP] aim of the study was to compare the effect of pretreatment with remifentanil 1 microg/kg and the effect of gender on the incidence of myoclo", "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 3774, 1927, 1920, 2161, 1982, 1942, 5175, 1920, 2495, 1927, 9111, 1956, 2500, 10528, 4905, 16692, 21, 12517, 19, 3621, 1930, 1920, 2495, 1927, 5125, 3]}, "items": [{"id": "p_916", "content": "remifentanil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 3]}]}
{"query": {"id": "q_917", "content": "myoclonus [SEP] ntanil 1 microg/kg and the effect of gender on the incidence of myoclonus after anesthesia induction with etomidate. DESIGN: This was a r", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 20503, 8635, 1024, 21, 12517, 19, 3621, 1930, 1920, 2495, 1927, 5125, 1990, 1920, 4332, 1927, 15924, 2223, 1916, 1957, 2256, 8871, 4408, 1956, 2140, 3]}, "items": [{"id": "p_917", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_918", "content": "etomidate [SEP] r on the incidence of myoclonus after anesthesia induction with etomidate. DESIGN: This was a randomized, double-blind study. SETTING: Th", "tokenized_content": [2, 2140, 1947, 21550, 3, 60, 1990, 1920, 4332, 1927, 15924, 2223, 1916, 1957, 2256, 8871, 4408, 1956, 2140, 1947, 21550, 18, 3036, 30, 2052, 1982, 43, 5542, 16, 4825, 17, 3]}, "items": [{"id": "p_918", "content": "Etomidate [SEP] Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It ha", "score": 1, "type": null, "tokenized_content": [2, 2140, 1947, 21550, 3, 16045, 10533, 16111, 1930, 25810, 3153, 1956, 5082, 2495, 1990, 2877, 20374, 16, 10198, 16, 2014, 1920, 5321, 2433, 18, 2176, 2118, 3]}]}
{"query": {"id": "q_919", "content": "Myoclonus [SEP] placebo injection, etomidate 0.3 mg/kg was given. MEASUREMENTS: Myoclonus was recorded with a scale of 0 to 3. The grade of sedation (non", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 5936, 4107, 16, 2140, 1947, 21550, 20, 18, 23, 2786, 19, 3621, 1982, 3258, 18, 4146, 30, 15924, 2223, 1916, 1957, 1982, 4562, 1956, 43, 3]}, "items": [{"id": "p_919", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_920", "content": "nausea [SEP] f 0 to 3. The grade of sedation (none, mild, moderate, severe), nausea, pruritus, and apnea were recorded after injection of both drug", "tokenized_content": [2, 13759, 3, 48, 20, 1942, 23, 18, 1920, 4927, 1927, 15263, 12, 6046, 16, 5809, 16, 5086, 16, 4010, 13, 16, 13759, 16, 27496, 16, 1930, 17578, 1985, 4562, 2256, 3]}, "items": [{"id": "p_920", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_921", "content": "pruritus [SEP] . The grade of sedation (none, mild, moderate, severe), nausea, pruritus, and apnea were recorded after injection of both drugs. MAIN RE", "tokenized_content": [2, 27496, 3, 18, 1920, 4927, 1927, 15263, 12, 6046, 16, 5809, 16, 5086, 16, 4010, 13, 16, 13759, 16, 27496, 16, 1930, 17578, 1985, 4562, 2256, 4107, 1927, 2321, 4195, 3]}, "items": [{"id": "p_921", "content": "Pruritus [SEP] An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27496, 3, 1925, 10702, 20687, 1941, 15826, 1988, 9300, 1920, 11460, 1021, 1942, 10010, 2014, 18480, 1920, 4407, 1942, 5649, 13104, 18, 3]}]}
{"query": {"id": "q_922", "content": "apnea [SEP]  sedation (none, mild, moderate, severe), nausea, pruritus, and apnea were recorded after injection of both drugs. MAIN RESULTS: The ", "tokenized_content": [2, 17578, 3, 15263, 12, 6046, 16, 5809, 16, 5086, 16, 4010, 13, 16, 13759, 16, 27496, 16, 1930, 17578, 1985, 4562, 2256, 4107, 1927, 2321, 4195, 18, 2730, 2274, 30, 3]}, "items": [{"id": "p_922", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_923", "content": "Daidzein [SEP] Daidzein activates choline acetyltransferase from MC-IXC cells and impro", "tokenized_content": [2, 23708, 1007, 6931, 1921, 3, 23708, 1007, 6931, 1921, 9094, 15440, 22226, 2037, 4110, 17, 13848, 1030, 2094, 1930, 2816, 3]}, "items": [{"id": "p_923", "content": "daidzein [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23708, 1007, 6931, 1921, 3, 3]}]}
{"query": {"id": "q_924", "content": "choline [SEP] Daidzein activates choline acetyltransferase from MC-IXC cells and improves drug-induced a", "tokenized_content": [2, 15440, 3, 23708, 1007, 6931, 1921, 9094, 15440, 22226, 2037, 4110, 17, 13848, 1030, 2094, 1930, 10204, 2838, 17, 2719, 43, 3]}, "items": [{"id": "p_924", "content": "Choline [SEP] A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine,", "score": 1, "type": null, "tokenized_content": [2, 15440, 3, 43, 5937, 18690, 1927, 18430, 1953, 1921, 1988, 1977, 2435, 1922, 3086, 4793, 1930, 4027, 7393, 18, 2176, 1977, 2715, 1966, 43, 7897, 1927, 14561, 16, 3]}]}
{"query": {"id": "q_925", "content": "amnesia [SEP] e acetyltransferase from MC-IXC cells and improves drug-induced amnesia.", "tokenized_content": [2, 14701, 7156, 3, 47, 22226, 2037, 4110, 17, 13848, 1030, 2094, 1930, 10204, 2838, 17, 2719, 14701, 7156, 18, 3]}, "items": [{"id": "p_925", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_926", "content": "choline [SEP] The choline acetyltransferase (ChAT) activator, which enhances cholinergic ", "tokenized_content": [2, 15440, 3, 1920, 15440, 22226, 12, 20560, 13, 9518, 16, 2154, 9515, 13908, 3]}, "items": [{"id": "p_926", "content": "Choline [SEP] A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine,", "score": 1, "type": null, "tokenized_content": [2, 15440, 3, 43, 5937, 18690, 1927, 18430, 1953, 1921, 1988, 1977, 2435, 1922, 3086, 4793, 1930, 4027, 7393, 18, 2176, 1977, 2715, 1966, 43, 7897, 1927, 14561, 16, 3]}]}
{"query": {"id": "q_927", "content": "acetylcholine [SEP] transmission via an augmentation of the enzymatic production of acetylcholine (ACh), is an important factor in the treatment of Alzheimer's d", "tokenized_content": [2, 14561, 3, 5303, 3454, 1925, 16493, 1927, 1920, 8145, 3372, 1927, 14561, 12, 3546, 13, 16, 1977, 1925, 2715, 2991, 1922, 1920, 2311, 1927, 9116, 11, 61, 46, 3]}, "items": [{"id": "p_927", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_928", "content": "ACh [SEP] a an augmentation of the enzymatic production of acetylcholine (ACh), is an important factor in the treatment of Alzheimer's diseas", "tokenized_content": [2, 3546, 3, 43, 1925, 16493, 1927, 1920, 8145, 3372, 1927, 14561, 12, 3546, 13, 16, 1977, 1925, 2715, 2991, 1922, 1920, 2311, 1927, 9116, 11, 61, 2445, 1934, 3]}, "items": [{"id": "p_928", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_929", "content": "Alzheimer's disease [SEP] acetylcholine (ACh), is an important factor in the treatment of Alzheimer's disease (AD). Methanolic extracts from Pueraria thunbergiana exhibited ", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 14561, 12, 3546, 13, 16, 1977, 1925, 2715, 2991, 1922, 1920, 2311, 1927, 9116, 11, 61, 2573, 12, 2041, 13, 18, 8570, 1935, 6391, 2037, 3]}, "items": [{"id": "p_929", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_930", "content": "AD [SEP] is an important factor in the treatment of Alzheimer's disease (AD). Methanolic extracts from Pueraria thunbergiana exhibited an a", "tokenized_content": [2, 2041, 3, 1977, 1925, 2715, 2991, 1922, 1920, 2311, 1927, 9116, 11, 61, 2573, 12, 2041, 13, 18, 8570, 1935, 6391, 2037, 6612, 7124, 3027, 1019, 1913, 1983, 7519, 15626, 3]}, "items": [{"id": "p_930", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_931", "content": "daidzein [SEP] thunbergiana, the active component was ultimately identified as daidzein (4',7-dihydroxy-isoflavone). In order to investigate the effect", "tokenized_content": [2, 23708, 1007, 6931, 1921, 3, 1913, 1983, 7519, 15626, 16, 1920, 3500, 4594, 1982, 8676, 2899, 1966, 23708, 1007, 6931, 1921, 12, 24, 11, 16, 27, 17, 20684, 17, 24657, 3]}, "items": [{"id": "p_931", "content": "daidzein [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23708, 1007, 6931, 1921, 3, 3]}]}
{"query": {"id": "q_932", "content": "4',7-dihydroxy-isoflavone [SEP] na, the active component was ultimately identified as daidzein (4',7-dihydroxy-isoflavone). In order to investigate the effects of daidzein from Pueraria", "tokenized_content": [2, 24, 11, 16, 27, 17, 20684, 17, 24657, 2290, 3, 4049, 16, 1920, 3500, 4594, 1982, 8676, 2899, 1966, 23708, 1007, 6931, 1921, 12, 24, 11, 16, 27, 17, 20684, 3]}, "items": [{"id": "p_932", "content": "daidzein [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23708, 1007, 6931, 1921, 3, 3]}]}
{"query": {"id": "q_933", "content": "scopolamine [SEP] vestigate the effects of daidzein from Pueraria thunbergiana on scopolamine-induced impairments of learning and memory, we conducted a seri", "tokenized_content": [2, 25392, 10173, 25157, 3, 5634, 2677, 2010, 1920, 2564, 1927, 23708, 1007, 6931, 1921, 2037, 6612, 7124, 3027, 1019, 1913, 1983, 7519, 15626, 1990, 25392, 10173, 25157, 17, 2719, 12454, 3]}, "items": [{"id": "p_933", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_934", "content": "impairments of learning [SEP] s of daidzein from Pueraria thunbergiana on scopolamine-induced impairments of learning and memory, we conducted a series of in vivo tests. Administrat", "tokenized_content": [2, 12454, 1927, 4809, 3, 61, 1927, 23708, 1007, 6931, 1921, 2037, 6612, 7124, 3027, 1019, 1913, 1983, 7519, 15626, 1990, 25392, 10173, 25157, 17, 2719, 12454, 1927, 4809, 1930, 4525, 3]}, "items": [{"id": "p_934", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_935", "content": "amnesia [SEP]  to mice was shown significantly to reverse scopolamine-induced amnesia, according to the results of a Y-maze test. Injections of scopo", "tokenized_content": [2, 14701, 7156, 3, 1942, 2518, 1982, 2522, 2567, 1942, 5267, 25392, 10173, 25157, 17, 2719, 14701, 7156, 16, 3147, 1942, 1920, 2274, 1927, 43, 67, 17, 14476, 2648, 18, 8775, 3]}, "items": [{"id": "p_935", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_936", "content": "azithromycin [SEP] Possible azithromycin-associated hiccups.", "tokenized_content": [2, 28350, 3, 3216, 28350, 17, 2458, 27305, 18021, 2523, 18, 3]}, "items": [{"id": "p_936", "content": "Azithromycin [SEP] A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium a", "score": 1, "type": null, "tokenized_content": [2, 28350, 3, 43, 8762, 17, 6830, 23929, 2261, 7267, 12171, 2712, 1942, 22925, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 16389, 43, 3]}]}
{"query": {"id": "q_937", "content": "hiccups [SEP] Possible azithromycin-associated hiccups.", "tokenized_content": [2, 27305, 18021, 2523, 3, 3216, 28350, 17, 2458, 27305, 18021, 2523, 18, 3]}, "items": [{"id": "p_937", "content": "Hiccup [SEP] A spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27305, 18021, 1034, 3, 43, 24431, 1927, 1920, 16108, 1988, 5092, 43, 12446, 14728, 3489, 2007, 4052, 10408, 1927, 1920, 25632, 3519, 1937, 2154, 9300, 43, 8454, 18, 3]}]}
{"query": {"id": "q_938", "content": "hiccups [SEP] OBJECTIVE: To report a case of persistent hiccups associated by azithromycin therapy. CASE SUMMARY: A 76-year-old", "tokenized_content": [2, 27305, 18021, 2523, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 7733, 27305, 18021, 2523, 2458, 2007, 28350, 3181, 18, 3087, 6099, 30, 43, 5439, 17, 2476, 17, 4156, 3]}, "items": [{"id": "p_938", "content": "Hiccup [SEP] A spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27305, 18021, 1034, 3, 43, 24431, 1927, 1920, 16108, 1988, 5092, 43, 12446, 14728, 3489, 2007, 4052, 10408, 1927, 1920, 25632, 3519, 1937, 2154, 9300, 43, 8454, 18, 3]}]}
{"query": {"id": "q_939", "content": "azithromycin [SEP] OBJECTIVE: To report a case of persistent hiccups associated by azithromycin therapy. CASE SUMMARY: A 76-year-old man presented with persist", "tokenized_content": [2, 28350, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 7733, 27305, 18021, 2523, 2458, 2007, 28350, 3181, 18, 3087, 6099, 30, 43, 5439, 17, 2476, 17, 4156, 2323, 3549, 1956, 3]}, "items": [{"id": "p_939", "content": "Azithromycin [SEP] A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium a", "score": 1, "type": null, "tokenized_content": [2, 28350, 3, 43, 8762, 17, 6830, 23929, 2261, 7267, 12171, 2712, 1942, 22925, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 16389, 43, 3]}]}
{"query": {"id": "q_940", "content": "pharyngitis [SEP] stent hiccups after beginning azithromycin for the treatment of pharyngitis. Hiccups were persistent and exhausting. Discontinuation of azi", "tokenized_content": [2, 18421, 6907, 2029, 3678, 3, 10772, 27305, 18021, 2523, 2256, 7828, 28350, 1958, 1920, 2311, 1927, 18421, 6907, 2029, 3678, 18, 27305, 18021, 2523, 1985, 7733, 1930, 13246, 2104, 18, 3]}, "items": [{"id": "p_940", "content": "Pharyngitis [SEP] Inflammation of the throat (PHARYNX).\n    ", "score": 1, "type": null, "tokenized_content": [2, 18421, 6907, 2029, 3678, 3, 4531, 1927, 1920, 23555, 12, 18421, 6907, 14272, 13, 18, 3]}]}
{"query": {"id": "q_941", "content": "Hiccups [SEP]  after beginning azithromycin for the treatment of pharyngitis. Hiccups were persistent and exhausting. Discontinuation of azithromycin", "tokenized_content": [2, 27305, 18021, 2523, 3, 2256, 7828, 28350, 1958, 1920, 2311, 1927, 18421, 6907, 2029, 3678, 18, 27305, 18021, 2523, 1985, 7733, 1930, 13246, 2104, 18, 14775, 1927, 28350, 3]}, "items": [{"id": "p_941", "content": "Hiccup [SEP] A spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27305, 18021, 1034, 3, 43, 24431, 1927, 1920, 16108, 1988, 5092, 43, 12446, 14728, 3489, 2007, 4052, 10408, 1927, 1920, 25632, 3519, 1937, 2154, 9300, 43, 8454, 18, 3]}]}
{"query": {"id": "q_942", "content": "baclofen [SEP] nd exhausting. Discontinuation of azithromycin and therapy with baclofen finally resolved hiccups. No organic cause of hiccups was ident", "tokenized_content": [2, 30491, 18514, 3, 8026, 13246, 2104, 18, 14775, 1927, 28350, 1930, 3181, 1956, 30491, 18514, 4342, 8397, 27305, 18021, 2523, 18, 2239, 6805, 3936, 1927, 27305, 18021, 2523, 1982, 6023, 3]}, "items": [{"id": "p_942", "content": "Baclofen [SEP] A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPAST", "score": 1, "type": null, "tokenized_content": [2, 30491, 18514, 3, 43, 7034, 17, 29093, 2687, 10533, 1988, 1977, 43, 2487, 7829, 1927, 7992, 17, 44, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3760, 19361, 2156, 3]}]}
{"query": {"id": "q_943", "content": "dexamethasone [SEP]  have been uncommonly associated with hiccups. Corticosteroids (dexamethasone and methylprednisolone), benzodiazepines (midazolam) and genera", "tokenized_content": [2, 12681, 3, 2162, 2252, 14403, 1954, 2458, 1956, 27305, 18021, 2523, 18, 14610, 12, 12681, 1930, 30087, 13, 16, 26555, 12, 23380, 13, 1930, 12774, 3]}, "items": [{"id": "p_943", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_944", "content": "methylprednisolone [SEP] nly associated with hiccups. Corticosteroids (dexamethasone and methylprednisolone), benzodiazepines (midazolam) and general anaesthesia have been", "tokenized_content": [2, 30087, 3, 9092, 1012, 2458, 1956, 27305, 18021, 2523, 18, 14610, 12, 12681, 1930, 30087, 13, 16, 26555, 12, 23380, 13, 1930, 3335, 17107, 2162, 2252, 3]}, "items": [{"id": "p_944", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_945", "content": "benzodiazepines [SEP] iccups. Corticosteroids (dexamethasone and methylprednisolone), benzodiazepines (midazolam) and general anaesthesia have been the specific agen", "tokenized_content": [2, 26555, 3, 12109, 25372, 18, 14610, 12, 12681, 1930, 30087, 13, 16, 26555, 12, 23380, 13, 1930, 3335, 17107, 2162, 2252, 1920, 2487, 2632, 1022, 3]}, "items": [{"id": "p_945", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_946", "content": "midazolam [SEP] eroids (dexamethasone and methylprednisolone), benzodiazepines (midazolam) and general anaesthesia have been the specific agents mentione", "tokenized_content": [2, 23380, 3, 2668, 4929, 12, 12681, 1930, 30087, 13, 16, 26555, 12, 23380, 13, 1930, 3335, 17107, 2162, 2252, 1920, 2487, 4820, 14515, 1021, 3]}, "items": [{"id": "p_946", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_947", "content": "macrolide [SEP] Few cases of drug-induced hiccups have been reported related to macrolide antimicrobials. Using the Naranjo adverse effect reaction proba", "tokenized_content": [2, 23929, 2261, 3, 3855, 2919, 1927, 2838, 17, 2719, 27305, 18021, 2523, 2162, 2252, 2568, 2712, 1942, 23929, 2261, 23044, 18, 2193, 1920, 7612, 1928, 15064, 5246, 2495, 3227, 2680, 3]}, "items": [{"id": "p_947", "content": "Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ", "score": 1, "type": null, "tokenized_content": [2, 23929, 3726, 3, 43, 2210, 1927, 3868, 17514, 21924, 13153, 4300, 5333, 2007, 4659, 7140, 1927, 3137, 24682, 1036, 3637, 2301, 2460, 43, 3103, 12, 2357, 3]}]}
{"query": {"id": "q_948", "content": "macrolides [SEP] temporal sequence, previous reports on this reaction with other macrolides and the absence of any alternative explanation for hiccups. Our", "tokenized_content": [2, 23929, 3726, 3, 5338, 3244, 16, 2555, 4710, 1990, 2052, 3227, 1956, 2303, 23929, 3726, 1930, 1920, 3905, 1927, 2967, 5012, 8042, 1958, 27305, 18021, 2523, 18, 2342, 3]}, "items": [{"id": "p_948", "content": "Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ", "score": 1, "type": null, "tokenized_content": [2, 23929, 3726, 3, 43, 2210, 1927, 3868, 17514, 21924, 13153, 4300, 5333, 2007, 4659, 7140, 1927, 3137, 24682, 1036, 3637, 2301, 2460, 43, 3103, 12, 2357, 3]}]}
{"query": {"id": "q_949", "content": "warfarin [SEP] Time trends in warfarin-associated hemorrhage.", "tokenized_content": [2, 16170, 3, 2367, 8064, 1922, 16170, 17, 2458, 10489, 18, 3]}, "items": [{"id": "p_949", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_950", "content": "hemorrhage [SEP] Time trends in warfarin-associated hemorrhage.", "tokenized_content": [2, 10489, 3, 2367, 8064, 1922, 16170, 17, 2458, 10489, 18, 3]}, "items": [{"id": "p_950", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_951", "content": "warfarin [SEP] The annual incidence of warfarin-related bleeding at Brigham and Women's Hospital increased from", "tokenized_content": [2, 16170, 3, 1920, 7780, 4332, 1927, 16170, 17, 2712, 7633, 2019, 2387, 2034, 1976, 1930, 3089, 11, 61, 3461, 2502, 2037, 3]}, "items": [{"id": "p_951", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_952", "content": "bleeding [SEP] The annual incidence of warfarin-related bleeding at Brigham and Women's Hospital increased from 0.97/1,000 patie", "tokenized_content": [2, 7633, 3, 1920, 7780, 4332, 1927, 16170, 17, 2712, 7633, 2019, 2387, 2034, 1976, 1930, 3089, 11, 61, 3461, 2502, 2037, 20, 18, 5749, 19, 21, 16, 3240, 2091, 1021, 3]}, "items": [{"id": "p_952", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_953", "content": "intracranial bleeding [SEP]  2002) of this study. The proportion of patients with major and intracranial bleeding increased from 20.2% and 1.9%, respectively, in the first time ", "tokenized_content": [2, 12179, 7633, 3, 4631, 13, 1927, 2052, 2161, 18, 1920, 4242, 1927, 2132, 1956, 3044, 1930, 12179, 7633, 2502, 2037, 2036, 18, 22, 9, 1930, 21, 18, 29, 9, 16, 3]}, "items": [{"id": "p_953", "content": "Intracranial Hemorrhages [SEP] Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often lea", "score": 1, "type": null, "tokenized_content": [2, 12179, 10489, 1036, 3, 7633, 2651, 1920, 13682, 16, 2710, 10489, 1036, 1922, 1920, 3068, 1930, 1920, 2559, 5726, 1927, 10286, 1918, 18, 1920, 11781, 1927, 2877, 3868, 2071, 1019, 3]}]}
{"query": {"id": "q_954", "content": "haemorrhagic [SEP] Fatal haemorrhagic myocarditis secondary to cyclophosphamide therapy.", "tokenized_content": [2, 18586, 12550, 3, 11990, 18586, 12550, 27169, 4067, 1942, 17135, 3181, 18, 3]}, "items": [{"id": "p_954", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_955", "content": "myocarditis [SEP] Fatal haemorrhagic myocarditis secondary to cyclophosphamide therapy.", "tokenized_content": [2, 27169, 3, 11990, 18586, 12550, 27169, 4067, 1942, 17135, 3181, 18, 3]}, "items": [{"id": "p_955", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_956", "content": "cyclophosphamide [SEP] Fatal haemorrhagic myocarditis secondary to cyclophosphamide therapy.", "tokenized_content": [2, 17135, 3, 11990, 18586, 12550, 27169, 4067, 1942, 17135, 3181, 18, 3]}, "items": [{"id": "p_956", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_957", "content": "Haemorrhagic [SEP] Haemorrhagic myocarditis is a rare but important complication of cyclophosph", "tokenized_content": [2, 18586, 12550, 3, 18586, 12550, 27169, 1977, 43, 5844, 2308, 2715, 9388, 1927, 20585, 10647, 3508, 1023, 3]}, "items": [{"id": "p_957", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_958", "content": "myocarditis [SEP] Haemorrhagic myocarditis is a rare but important complication of cyclophosphamide therap", "tokenized_content": [2, 27169, 3, 18586, 12550, 27169, 1977, 43, 5844, 2308, 2715, 9388, 1927, 17135, 2709, 3]}, "items": [{"id": "p_958", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_959", "content": "cyclophosphamide [SEP] aemorrhagic myocarditis is a rare but important complication of cyclophosphamide therapy. Echocardiographic identification of the disorder can b", "tokenized_content": [2, 17135, 3, 10194, 12492, 18858, 2722, 11545, 27169, 1977, 43, 5844, 2308, 2715, 9388, 1927, 17135, 3181, 18, 18700, 4824, 1927, 1920, 4770, 2112, 44, 3]}, "items": [{"id": "p_959", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_960", "content": "Glyceryl trinitrate [SEP] Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migrai", "tokenized_content": [2, 7757, 2199, 23501, 26813, 3, 7757, 2199, 23501, 26813, 6387, 15413, 1927, 13258, 2979, 11826, 1019, 1922, 7416, 2045, 1927, 4119, 5504, 3]}, "items": [{"id": "p_960", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_961", "content": "migraine without aura [SEP] Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migraine with aura.", "tokenized_content": [2, 13258, 2979, 11826, 1019, 3, 7757, 2199, 23501, 26813, 6387, 15413, 1927, 13258, 2979, 11826, 1019, 1922, 7416, 2045, 1927, 13258, 1956, 11826, 1019, 18, 3]}, "items": [{"id": "p_961", "content": "Migraine without Aura [SEP] Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is character", "score": 1, "type": null, "tokenized_content": [2, 13258, 2979, 11826, 1019, 3, 7457, 12059, 25960, 24339, 16, 2084, 16757, 2014, 7936, 2007, 1925, 11826, 1019, 16, 1922, 15413, 11671, 24, 17, 4395, 3967, 18, 2176, 1977, 2728, 3]}]}
{"query": {"id": "q_962", "content": "migraine with aura [SEP] itrate induces attacks of migraine without aura in sufferers of migraine with aura.", "tokenized_content": [2, 13258, 1956, 11826, 1019, 3, 25096, 2010, 6387, 15413, 1927, 13258, 2979, 11826, 1019, 1922, 7416, 2045, 1927, 13258, 1956, 11826, 1019, 18, 3]}, "items": [{"id": "p_962", "content": "Migraine with Aura [SEP] A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or ac", "score": 1, "type": null, "tokenized_content": [2, 13258, 1956, 11826, 1019, 3, 43, 8856, 1927, 13258, 4770, 16, 4378, 2007, 7457, 15413, 1927, 10743, 7605, 3601, 12, 11826, 1019, 13, 1988, 25841, 2014, 2000, 3]}]}
{"query": {"id": "q_963", "content": "Migraine with aura [SEP] Migraine with aura and migraine without aura have the same pain phase, thus indica", "tokenized_content": [2, 13258, 1956, 11826, 1019, 3, 13258, 1956, 11826, 1019, 1930, 13258, 2979, 11826, 1019, 2162, 1920, 2841, 3594, 3193, 16, 2842, 29338, 3]}, "items": [{"id": "p_963", "content": "Migraine with Aura [SEP] A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or ac", "score": 1, "type": null, "tokenized_content": [2, 13258, 1956, 11826, 1019, 3, 43, 8856, 1927, 13258, 4770, 16, 4378, 2007, 7457, 15413, 1927, 10743, 7605, 3601, 12, 11826, 1019, 13, 1988, 25841, 2014, 2000, 3]}]}
{"query": {"id": "q_964", "content": "migraine without aura [SEP] Migraine with aura and migraine without aura have the same pain phase, thus indicating that migraine with au", "tokenized_content": [2, 13258, 2979, 11826, 1019, 3, 13258, 1956, 11826, 1019, 1930, 13258, 2979, 11826, 1019, 2162, 1920, 2841, 3594, 3193, 16, 2842, 4168, 1988, 13258, 1956, 5759, 3]}, "items": [{"id": "p_964", "content": "Migraine without Aura [SEP] Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is character", "score": 1, "type": null, "tokenized_content": [2, 13258, 2979, 11826, 1019, 3, 7457, 12059, 25960, 24339, 16, 2084, 16757, 2014, 7936, 2007, 1925, 11826, 1019, 16, 1922, 15413, 11671, 24, 17, 4395, 3967, 18, 2176, 1977, 2728, 3]}]}
{"query": {"id": "q_965", "content": "pain [SEP] Migraine with aura and migraine without aura have the same pain phase, thus indicating that migraine with aura and migraine wit", "tokenized_content": [2, 3594, 3, 13258, 1956, 11826, 1019, 1930, 13258, 2979, 11826, 1019, 2162, 1920, 2841, 3594, 3193, 16, 2842, 4168, 1988, 13258, 1956, 11826, 1019, 1930, 13258, 16086, 3]}, "items": [{"id": "p_965", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_966", "content": "migraine with aura [SEP] ine without aura have the same pain phase, thus indicating that migraine with aura and migraine without aura share a common pathway of nociception", "tokenized_content": [2, 13258, 1956, 11826, 1019, 3, 11116, 2979, 11826, 1019, 2162, 1920, 2841, 3594, 3193, 16, 2842, 4168, 1988, 13258, 1956, 11826, 1019, 1930, 13258, 2979, 11826, 1019, 7948, 43, 3059, 3]}, "items": [{"id": "p_966", "content": "Migraine with Aura [SEP] A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or ac", "score": 1, "type": null, "tokenized_content": [2, 13258, 1956, 11826, 1019, 3, 43, 8856, 1927, 13258, 4770, 16, 4378, 2007, 7457, 15413, 1927, 10743, 7605, 3601, 12, 11826, 1019, 13, 1988, 25841, 2014, 2000, 3]}]}
{"query": {"id": "q_967", "content": "nitric oxide [SEP] , increasing evidence has suggested that the messenger molecule nitric oxide (NO) is involved in pain mechanisms of migraine without aura. I", "tokenized_content": [2, 10233, 7491, 3, 16, 3605, 3095, 2258, 3978, 1988, 1920, 16716, 5388, 10233, 7491, 12, 2239, 13, 1977, 3286, 1922, 3594, 3531, 1927, 13258, 2979, 11826, 1019, 18, 51, 3]}, "items": [{"id": "p_967", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_968", "content": "NO [SEP] vidence has suggested that the messenger molecule nitric oxide (NO) is involved in pain mechanisms of migraine without aura. In or", "tokenized_content": [2, 2239, 3, 7376, 15895, 1021, 2258, 3978, 1988, 1920, 16716, 5388, 10233, 7491, 12, 2239, 13, 1977, 3286, 1922, 3594, 3531, 1927, 13258, 2979, 11826, 1019, 18, 1922, 2014, 3]}, "items": [{"id": "p_968", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_969", "content": "headache [SEP] ue for migraine with aura, in the present study we examined the headache response to intravenous infusion of glyceryl trinitrate (GTN) (", "tokenized_content": [2, 12187, 3, 63, 1021, 1958, 13258, 1956, 11826, 1019, 16, 1922, 1920, 2481, 2161, 2038, 3572, 1920, 12187, 2644, 1942, 7307, 7386, 1927, 7757, 2199, 23501, 26813, 12, 4637, 1022, 3]}, "items": [{"id": "p_969", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_970", "content": "glyceryl trinitrate [SEP] dy we examined the headache response to intravenous infusion of glyceryl trinitrate (GTN) (0.5 microg/kg/min for 20 min) in 12 sufferers of migrain", "tokenized_content": [2, 7757, 2199, 23501, 26813, 3, 6433, 2038, 3572, 1920, 12187, 2644, 1942, 7307, 7386, 1927, 7757, 2199, 23501, 26813, 12, 4637, 1022, 13, 12, 20, 18, 25, 12517, 19, 3621, 3]}, "items": [{"id": "p_970", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_971", "content": "GTN [SEP] adache response to intravenous infusion of glyceryl trinitrate (GTN) (0.5 microg/kg/min for 20 min) in 12 sufferers of migraine wit", "tokenized_content": [2, 4637, 1022, 3, 20357, 15404, 2644, 1942, 7307, 7386, 1927, 7757, 2199, 23501, 26813, 12, 4637, 1022, 13, 12, 20, 18, 25, 12517, 19, 3621, 19, 2360, 1958, 2036, 2360, 3]}, "items": [{"id": "p_971", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_972", "content": "Headache [SEP] ed as controls. Aura symptoms were not elicited in any subject. Headache was more severe in migraineurs than in the controls during and ", "tokenized_content": [2, 12187, 3, 3347, 1966, 3562, 18, 11826, 1019, 3601, 1985, 2084, 9856, 1922, 2967, 5198, 18, 12187, 1982, 2253, 4010, 1922, 13258, 2920, 2254, 1922, 1920, 3562, 2409, 1930, 3]}, "items": [{"id": "p_972", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_973", "content": "migraineurs [SEP] s were not elicited in any subject. Headache was more severe in migraineurs than in the controls during and immediately after GTN infusion ", "tokenized_content": [2, 13258, 2920, 3, 61, 1985, 2084, 9856, 1922, 2967, 5198, 18, 12187, 1982, 2253, 4010, 1922, 13258, 2920, 2254, 1922, 1920, 3562, 2409, 1930, 6183, 2256, 4637, 1022, 7386, 3]}, "items": [{"id": "p_973", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_974", "content": "depression [SEP] pain mechanisms of migraine with aura. Since cortical spreading depression has been shown to liberate NO in animals, this finding may help", "tokenized_content": [2, 4621, 3, 3594, 3531, 1927, 13258, 1956, 11826, 1019, 18, 3328, 5586, 13405, 4621, 2258, 2252, 2522, 1942, 9954, 13108, 2239, 1922, 3555, 16, 2052, 2849, 2278, 4087, 3]}, "items": [{"id": "p_974", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_975", "content": "Stroke [SEP] Stroke and cocaine or amphetamine use.", "tokenized_content": [2, 5235, 3, 5235, 1930, 9045, 2014, 19057, 2485, 18, 3]}, "items": [{"id": "p_975", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_976", "content": "cocaine [SEP] Stroke and cocaine or amphetamine use.", "tokenized_content": [2, 9045, 3, 5235, 1930, 9045, 2014, 19057, 2485, 18, 3]}, "items": [{"id": "p_976", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_977", "content": "amphetamine [SEP] Stroke and cocaine or amphetamine use.", "tokenized_content": [2, 19057, 3, 5235, 1930, 9045, 2014, 19057, 2485, 18, 3]}, "items": [{"id": "p_977", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_978", "content": "cocaine [SEP] The association of cocaine and amphetamine use with hemorrhagic and ischemic stroke is bas", "tokenized_content": [2, 9045, 3, 1920, 3279, 1927, 9045, 1930, 19057, 2485, 1956, 16052, 1930, 7427, 5235, 1977, 2726, 3]}, "items": [{"id": "p_978", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_979", "content": "amphetamine [SEP] The association of cocaine and amphetamine use with hemorrhagic and ischemic stroke is based almost solely", "tokenized_content": [2, 19057, 3, 1920, 3279, 1927, 9045, 1930, 19057, 2485, 1956, 16052, 1930, 7427, 5235, 1977, 2454, 5365, 10870, 3]}, "items": [{"id": "p_979", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_980", "content": "ischemic [SEP] association of cocaine and amphetamine use with hemorrhagic and ischemic stroke is based almost solely on data from case series. The lim", "tokenized_content": [2, 7427, 3, 3279, 1927, 9045, 1930, 19057, 2485, 1956, 16052, 1930, 7427, 5235, 1977, 2454, 5365, 10870, 1990, 2230, 2037, 3087, 4696, 18, 1920, 2784, 3]}, "items": [{"id": "p_980", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_981", "content": "stroke [SEP] on of cocaine and amphetamine use with hemorrhagic and ischemic stroke is based almost solely on data from case series. The limited nu", "tokenized_content": [2, 5235, 3, 1990, 1927, 9045, 1930, 19057, 2485, 1956, 16052, 1930, 7427, 5235, 1977, 2454, 5365, 10870, 1990, 2230, 2037, 3087, 4696, 18, 1920, 3892, 13232, 3]}, "items": [{"id": "p_981", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_982", "content": "strokes [SEP]  and Southern California. We attempted to identify all incident strokes in women ages 15-44 years during a 3-year period using hospital", "tokenized_content": [2, 21655, 3, 1930, 9257, 10191, 18, 2038, 11189, 1942, 3512, 2136, 9706, 21655, 1922, 3089, 7684, 2461, 17, 4044, 2739, 2409, 43, 23, 17, 2476, 3047, 2193, 3461, 3]}, "items": [{"id": "p_982", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_983", "content": "breast cancer [SEP] Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomise", "tokenized_content": [2, 3739, 2539, 3, 5455, 1927, 3739, 2539, 1956, 13011, 30, 8458, 3056, 2037, 1920, 15922, 3332, 2870, 3]}, "items": [{"id": "p_983", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_984", "content": "tamoxifen [SEP] Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among h", "tokenized_content": [2, 13011, 3, 5455, 1927, 3739, 2539, 1956, 13011, 30, 8458, 3056, 2037, 1920, 15922, 12090, 3046, 2706, 50, 3]}, "items": [{"id": "p_984", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_985", "content": "Tamoxifen [SEP] e Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study.", "tokenized_content": [2, 13011, 3, 47, 15922, 12090, 3046, 2706, 13892, 14503, 3495, 3089, 18, 15922, 13011, 5455, 2161, 18, 3]}, "items": [{"id": "p_985", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_986", "content": "Tamoxifen [SEP] BACKGROUND: Tamoxifen is a candidate chemopreventive agent in breast cancer, although", "tokenized_content": [2, 13011, 3, 3872, 30, 13011, 1977, 43, 6610, 22896, 5954, 2320, 5899, 1922, 3739, 2539, 16, 2876, 3]}, "items": [{"id": "p_986", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_987", "content": "breast cancer [SEP] BACKGROUND: Tamoxifen is a candidate chemopreventive agent in breast cancer, although the drug may be associated with the development of en", "tokenized_content": [2, 3739, 2539, 3, 3872, 30, 13011, 1977, 43, 6610, 22896, 5954, 2320, 5899, 1922, 3739, 2539, 16, 2876, 1920, 2838, 2278, 1998, 2458, 1956, 1920, 2740, 1927, 2066, 3]}, "items": [{"id": "p_987", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_988", "content": "endometrial cancer [SEP] er, although the drug may be associated with the development of endometrial cancer. Therefore we did a trial in hysterectomised women of tamoxifen", "tokenized_content": [2, 11634, 2539, 3, 2668, 16, 2876, 1920, 2838, 2278, 1998, 2458, 1956, 1920, 2740, 1927, 11634, 2539, 18, 2955, 2038, 2811, 43, 3046, 1922, 13892, 14503, 3495, 3089, 1927, 13011, 3]}, "items": [{"id": "p_988", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_989", "content": "tamoxifen [SEP] al cancer. Therefore we did a trial in hysterectomised women of tamoxifen as a chemopreventive. METHODS: In October, 1992, we started a d", "tokenized_content": [2, 13011, 3, 1969, 2539, 18, 2955, 2038, 2811, 43, 3046, 1922, 13892, 14503, 3495, 3089, 1927, 13011, 1966, 43, 22896, 5954, 2320, 18, 2860, 30, 1922, 11722, 16, 8348, 16, 3]}, "items": [{"id": "p_989", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_990", "content": "breast-cancer [SEP] ve been no deaths from breast cancer. There is no difference in breast-cancer frequency between the placebo (22 cases) and tamoxifen (19) arm", "tokenized_content": [2, 3739, 17, 2539, 3, 3428, 2252, 2239, 7601, 2037, 3739, 2539, 18, 2276, 1977, 2239, 3175, 1922, 3739, 17, 2539, 3528, 2192, 1920, 5936, 12, 2950, 2919, 13, 1930, 13011, 3]}, "items": [{"id": "p_990", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_991", "content": "vascular events [SEP]  the placebo group, there was a significantly increased risk of vascular events and hypertriglyceridaemia among women on tamoxifen. INTERPRETAT", "tokenized_content": [2, 4541, 3916, 3, 1920, 5936, 2210, 16, 2276, 1982, 43, 2567, 2502, 2565, 1927, 4541, 3916, 1930, 30166, 10828, 6026, 2706, 3089, 1990, 13011, 18, 10307, 1926, 3]}, "items": [{"id": "p_991", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_992", "content": "hypertriglyceridaemia [SEP] there was a significantly increased risk of vascular events and hypertriglyceridaemia among women on tamoxifen. INTERPRETATION: Although this prelimi", "tokenized_content": [2, 30166, 10828, 6026, 3, 2276, 1982, 43, 2567, 2502, 2565, 1927, 4541, 3916, 1930, 30166, 10828, 6026, 2706, 3089, 1990, 13011, 18, 6332, 30, 2876, 2052, 8241, 1033, 3]}, "items": [{"id": "p_992", "content": "Hypertriglyceridemia [SEP] A condition of elevated levels of TRIGLYCERIDES in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30166, 12704, 3, 43, 2625, 1927, 4664, 2428, 1927, 13631, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_993", "content": "pupillary oscillation [SEP] A measure of pupillary oscillation as a marker of cocaine-induced paranoia.", "tokenized_content": [2, 19878, 5148, 6907, 17548, 3, 43, 2931, 1927, 19878, 5148, 6907, 17548, 1966, 43, 4966, 1927, 9045, 17, 2719, 26124, 26822, 1019, 18, 3]}, "items": [{"id": "p_993", "content": "Pupil Disorders [SEP] Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary c", "score": 1, "type": null, "tokenized_content": [2, 19878, 4414, 3, 2961, 2154, 4081, 1920, 3170, 2014, 2347, 1927, 1920, 19878, 1927, 1920, 5723, 16, 2710, 4414, 1927, 19099, 1942, 1920, 19878, 5148, 6907, 45, 3]}]}
{"query": {"id": "q_994", "content": "cocaine [SEP] A measure of pupillary oscillation as a marker of cocaine-induced paranoia.", "tokenized_content": [2, 9045, 3, 43, 2931, 1927, 19878, 5148, 6907, 17548, 1966, 43, 4966, 1927, 9045, 17, 2719, 26124, 26822, 1019, 18, 3]}, "items": [{"id": "p_994", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_995", "content": "paranoia [SEP] measure of pupillary oscillation as a marker of cocaine-induced paranoia.", "tokenized_content": [2, 26124, 26822, 1019, 3, 2931, 1927, 19878, 5148, 6907, 17548, 1966, 43, 4966, 1927, 9045, 17, 2719, 26124, 26822, 1019, 18, 3]}, "items": [{"id": "p_995", "content": "Paranoid Disorders [SEP] Chronic mental disorders in which there has been an insidious development of a permanent and unshakeable delusional system (pers", "score": 1, "type": null, "tokenized_content": [2, 26124, 2642, 4414, 3, 3724, 5018, 4414, 1922, 2154, 2276, 2258, 2252, 1925, 2346, 13756, 2080, 2740, 1927, 43, 11047, 1930, 6398, 2722, 3324, 2115, 2723, 2670, 1923, 2433, 12, 3096, 3]}]}
{"query": {"id": "q_996", "content": "Cocaine [SEP] Cocaine-induced paranoia (CIP) remains an important drug-induced model ", "tokenized_content": [2, 9045, 3, 9045, 17, 2719, 26124, 26822, 1019, 12, 12998, 13, 4497, 1925, 2715, 2838, 17, 2719, 2322, 3]}, "items": [{"id": "p_996", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_997", "content": "paranoia [SEP] Cocaine-induced paranoia (CIP) remains an important drug-induced model of idiopathic par", "tokenized_content": [2, 26124, 26822, 1019, 3, 9045, 17, 2719, 26124, 26822, 1019, 12, 12998, 13, 4497, 1925, 2715, 2838, 17, 2719, 2322, 1927, 13513, 2096, 3]}, "items": [{"id": "p_997", "content": "Paranoid Disorders [SEP] Chronic mental disorders in which there has been an insidious development of a permanent and unshakeable delusional system (pers", "score": 1, "type": null, "tokenized_content": [2, 26124, 2642, 4414, 3, 3724, 5018, 4414, 1922, 2154, 2276, 2258, 2252, 1925, 2346, 13756, 2080, 2740, 1927, 43, 11047, 1930, 6398, 2722, 3324, 2115, 2723, 2670, 1923, 2433, 12, 3096, 3]}]}
{"query": {"id": "q_998", "content": "CIP [SEP] Cocaine-induced paranoia (CIP) remains an important drug-induced model of idiopathic paranoia", "tokenized_content": [2, 12998, 3, 9045, 17, 2719, 26124, 26822, 1019, 12, 12998, 13, 4497, 1925, 2715, 2838, 17, 2719, 2322, 1927, 13513, 26124, 26822, 1019, 3]}, "items": [{"id": "p_998", "content": "Paranoid Disorders [SEP] Chronic mental disorders in which there has been an insidious development of a permanent and unshakeable delusional system (pers", "score": 1, "type": null, "tokenized_content": [2, 26124, 2642, 4414, 3, 3724, 5018, 4414, 1922, 2154, 2276, 2258, 2252, 1925, 2346, 13756, 2080, 2740, 1927, 43, 11047, 1930, 6398, 2722, 3324, 2115, 2723, 2670, 1923, 2433, 12, 3096, 3]}]}
{"query": {"id": "q_999", "content": "pupillary oscillation [SEP]  which no psychophysiologic marker has yet emerged. Measures of pupillary oscillation were able to significantly distinguish a group of abstinent cra", "tokenized_content": [2, 19878, 5148, 6907, 17548, 3, 2154, 2239, 21180, 12649, 4966, 2258, 4898, 9287, 18, 3975, 1927, 19878, 5148, 6907, 17548, 1985, 4236, 1942, 2567, 7279, 43, 2210, 1927, 14505, 1939, 3]}, "items": [{"id": "p_999", "content": "Pupil Disorders [SEP] Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary c", "score": 1, "type": null, "tokenized_content": [2, 19878, 4414, 3, 2961, 2154, 4081, 1920, 3170, 2014, 2347, 1927, 1920, 19878, 1927, 1920, 5723, 16, 2710, 4414, 1927, 19099, 1942, 1920, 19878, 5148, 6907, 45, 3]}]}
{"query": {"id": "q_1000", "content": "crack cocaine [SEP] ion were able to significantly distinguish a group of abstinent crack cocaine abusers endorsing past CIP (n = 32) from another group of crack", "tokenized_content": [2, 14480, 9045, 3, 4755, 1985, 4236, 1942, 2567, 7279, 43, 2210, 1927, 14505, 1939, 14480, 9045, 7764, 5675, 14897, 1941, 5375, 12998, 12, 56, 33, 3323, 13, 2037, 3741, 2210, 3]}, "items": [{"id": "p_1000", "content": "Crack Cocaine [SEP] The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. ", "score": 1, "type": null, "tokenized_content": [2, 14480, 9045, 3, 1920, 4939, 16, 29951, 1923, 16, 8324, 17, 6828, 2386, 1927, 9045, 18, 2176, 1977, 17872, 12, 3294, 17, 2454, 13, 16, 5624, 15132, 16, 1930, 12950, 20833, 18, 3]}]}
{"query": {"id": "q_1001", "content": "crack [SEP] ion were able to significantly distinguish a group of abstinent crack cocaine abusers endorsing past CIP (n = 32) from another group ", "tokenized_content": [2, 14480, 3, 4755, 1985, 4236, 1942, 2567, 7279, 43, 2210, 1927, 14505, 1939, 14480, 9045, 7764, 5675, 14897, 1941, 5375, 12998, 12, 56, 33, 3323, 13, 2037, 3741, 2210, 3]}, "items": [{"id": "p_1001", "content": "Crack Cocaine [SEP] The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. ", "score": 1, "type": null, "tokenized_content": [2, 14480, 9045, 3, 1920, 4939, 16, 29951, 1923, 16, 8324, 17, 6828, 2386, 1927, 9045, 18, 2176, 1977, 17872, 12, 3294, 17, 2454, 13, 16, 5624, 15132, 16, 1930, 12950, 20833, 18, 3]}]}
{"query": {"id": "q_1002", "content": "Seizures [SEP] Seizures induced by combined levomepromazine-fluvoxamine treatment.", "tokenized_content": [2, 10060, 3, 10060, 2719, 2007, 4252, 30129, 3870, 2216, 3368, 22030, 2912, 17, 2848, 15525, 11414, 25157, 2311, 18, 3]}, "items": [{"id": "p_1002", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1003", "content": "levomepromazine [SEP] Seizures induced by combined levomepromazine-fluvoxamine treatment.", "tokenized_content": [2, 30129, 3870, 2216, 3368, 22030, 2912, 3, 10060, 2719, 2007, 4252, 30129, 3870, 2216, 3368, 22030, 2912, 17, 2848, 15525, 11414, 25157, 2311, 18, 3]}, "items": [{"id": "p_1003", "content": "Methotrimeprazine [SEP] A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-anta", "score": 1, "type": null, "tokenized_content": [2, 17996, 3027, 3870, 13399, 22030, 2912, 3, 43, 3037, 30354, 2053, 1956, 7683, 2455, 2551, 1942, 1988, 1927, 2321, 4891, 2216, 3368, 22030, 2912, 1930, 2720, 3184, 10119, 18, 2176, 2258, 1920, 14622, 17, 4942, 1019, 3]}]}
{"query": {"id": "q_1004", "content": "fluvoxamine [SEP] Seizures induced by combined levomepromazine-fluvoxamine treatment.", "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 10060, 2719, 2007, 4252, 30129, 3870, 2216, 3368, 22030, 2912, 17, 2848, 15525, 11414, 25157, 2311, 18, 3]}, "items": [{"id": "p_1004", "content": "Fluvoxamine [SEP] A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 43, 5328, 11153, 22957, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 1930, 43, 5386, 1927, 5592, 4414, 18, 3]}]}
{"query": {"id": "q_1005", "content": "levomepromazine [SEP] We report a case of combined levomepromazine-fluvoxamine treatment-induced seizures. It seems that combined ", "tokenized_content": [2, 30129, 3870, 2216, 3368, 22030, 2912, 3, 2038, 3809, 43, 3087, 1927, 4252, 30129, 3870, 2216, 3368, 22030, 2912, 17, 2848, 15525, 11414, 25157, 2311, 17, 2719, 10060, 18, 2176, 3]}, "items": [{"id": "p_1005", "content": "Methotrimeprazine [SEP] A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-anta", "score": 1, "type": null, "tokenized_content": [2, 17996, 3027, 3870, 13399, 22030, 2912, 3, 43, 3037, 30354, 2053, 1956, 7683, 2455, 2551, 1942, 1988, 1927, 2321, 4891, 2216, 3368, 22030, 2912, 1930, 2720, 3184, 10119, 18, 2176, 2258, 1920, 14622, 17, 4942, 1019, 3]}]}
{"query": {"id": "q_1006", "content": "fluvoxamine [SEP] We report a case of combined levomepromazine-fluvoxamine treatment-induced seizures. It seems that combined treatment of", "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 2038, 3809, 43, 3087, 1927, 4252, 30129, 3870, 2216, 3368, 22030, 2912, 17, 2848, 15525, 11414, 25157, 2311, 17, 2719, 10060, 18, 2176, 6123, 1988, 3]}, "items": [{"id": "p_1006", "content": "Fluvoxamine [SEP] A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 43, 5328, 11153, 22957, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 1930, 43, 5386, 1927, 5592, 4414, 18, 3]}]}
{"query": {"id": "q_1007", "content": "seizures [SEP]  case of combined levomepromazine-fluvoxamine treatment-induced seizures. It seems that combined treatment of fluvoxamine with phenothia", "tokenized_content": [2, 10060, 3, 3087, 1927, 4252, 30129, 3870, 2216, 3368, 22030, 2912, 17, 2848, 15525, 11414, 25157, 2311, 17, 2719, 10060, 18, 2176, 6123, 1988, 4252, 2311, 1927, 2848, 15525, 11414, 3]}, "items": [{"id": "p_1007", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1008", "content": "phenothiazines [SEP]  seizures. It seems that combined treatment of fluvoxamine with phenothiazines may possess proconvulsive activity.", "tokenized_content": [2, 3037, 30354, 2613, 3, 10060, 18, 2176, 6123, 1988, 4252, 2311, 1927, 2848, 15525, 11414, 25157, 1956, 3037, 30354, 2613, 2278, 7150, 9823, 12766, 13042, 2455, 18, 3]}, "items": [{"id": "p_1008", "content": "Phenothiazines [SEP] Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3037, 30354, 2613, 3, 4300, 3165, 17239, 4389, 1037, 17, 21, 16, 24, 17, 27225, 2053, 18, 2673, 1927, 3581, 2032, 3366, 3849, 18, 3]}]}
{"query": {"id": "q_1009", "content": "epsilon-aminocaproic acid [SEP] Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature ", "tokenized_content": [2, 22206, 17, 3835, 9991, 1931, 1935, 2687, 3, 7348, 2278, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 4769, 25017, 1922, 2323, 35, 3809, 1927, 43, 3087, 3]}, "items": [{"id": "p_1009", "content": "Aminocaproic Acid [SEP] An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3835, 9991, 1931, 1935, 2687, 3, 1925, 12244, 3693, 21092, 4274, 5899, 1988, 8016, 2007, 7918, 17485, 15497, 2154, 2162, 9450, 6586, 3879, 18, 3]}]}
{"query": {"id": "q_1010", "content": "EACA [SEP] Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review", "tokenized_content": [2, 27848, 1019, 3, 7348, 2278, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 4769, 25017, 1922, 2323, 35, 3809, 1927, 43, 3087, 1930, 4431, 3043, 3]}, "items": [{"id": "p_1010", "content": "Aminocaproic Acid [SEP] An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3835, 9991, 1931, 1935, 2687, 3, 1925, 12244, 3693, 21092, 4274, 5899, 1988, 8016, 2007, 7918, 17485, 15497, 2154, 2162, 9450, 6586, 3879, 18, 3]}]}
{"query": {"id": "q_1011", "content": "myopathy [SEP] Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review.", "tokenized_content": [2, 25017, 3, 7348, 2278, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 4769, 25017, 1922, 2323, 35, 3809, 1927, 43, 3087, 1930, 4431, 3043, 18, 3]}, "items": [{"id": "p_1011", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1012", "content": "necrotizing [SEP] A case of necrotizing myopathy due to a short epsilon-aminocaproic acid (EACA) treatm", "tokenized_content": [2, 27438, 3, 43, 3087, 1927, 27438, 25017, 2810, 1942, 43, 3662, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 2297, 1035, 3]}, "items": [{"id": "p_1012", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_1013", "content": "myopathy [SEP] A case of necrotizing myopathy due to a short epsilon-aminocaproic acid (EACA) treatment in a ", "tokenized_content": [2, 25017, 3, 43, 3087, 1927, 27438, 25017, 2810, 1942, 43, 3662, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 2311, 1922, 43, 3]}, "items": [{"id": "p_1013", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1014", "content": "epsilon-aminocaproic acid [SEP] A case of necrotizing myopathy due to a short epsilon-aminocaproic acid (EACA) treatment in a 72 year-old patient with subarachnoid hae", "tokenized_content": [2, 22206, 17, 3835, 9991, 1931, 1935, 2687, 3, 43, 3087, 1927, 27438, 25017, 2810, 1942, 43, 3662, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 2311, 1922, 3]}, "items": [{"id": "p_1014", "content": "Aminocaproic Acid [SEP] An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3835, 9991, 1931, 1935, 2687, 3, 1925, 12244, 3693, 21092, 4274, 5899, 1988, 8016, 2007, 7918, 17485, 15497, 2154, 2162, 9450, 6586, 3879, 18, 3]}]}
{"query": {"id": "q_1015", "content": "EACA [SEP]  necrotizing myopathy due to a short epsilon-aminocaproic acid (EACA) treatment in a 72 year-old patient with subarachnoid haemorrha", "tokenized_content": [2, 27848, 1019, 3, 27438, 25017, 2810, 1942, 43, 3662, 22206, 17, 3835, 9991, 1931, 1935, 2687, 12, 27848, 1019, 13, 2311, 1922, 43, 4395, 2476, 17, 4156, 2774, 1956, 23795, 3]}, "items": [{"id": "p_1015", "content": "Aminocaproic Acid [SEP] An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3835, 9991, 1931, 1935, 2687, 3, 1925, 12244, 3693, 21092, 4274, 5899, 1988, 8016, 2007, 7918, 17485, 15497, 2154, 2162, 9450, 6586, 3879, 18, 3]}]}
{"query": {"id": "q_1016", "content": "subarachnoid haemorrhage [SEP] minocaproic acid (EACA) treatment in a 72 year-old patient with subarachnoid haemorrhage (SAH) is described. Pathogenetic hypotheses are discussed.", "tokenized_content": [2, 23795, 23352, 3, 2360, 29519, 1931, 1935, 2687, 12, 27848, 1019, 13, 2311, 1922, 43, 4395, 2476, 17, 4156, 2774, 1956, 23795, 23352, 12, 11738, 13, 1977, 2910, 18, 7055, 3]}, "items": [{"id": "p_1016", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_1017", "content": "SAH [SEP] eatment in a 72 year-old patient with subarachnoid haemorrhage (SAH) is described. Pathogenetic hypotheses are discussed.", "tokenized_content": [2, 11738, 3, 13619, 2017, 1922, 43, 4395, 2476, 17, 4156, 2774, 1956, 23795, 23352, 12, 11738, 13, 1977, 2910, 18, 7055, 3023, 10518, 2032, 5601, 18, 3]}, "items": [{"id": "p_1017", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_1018", "content": "ranitidine [SEP] Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with ga", "tokenized_content": [2, 2845, 2078, 27099, 3, 3723, 1927, 1920, 6001, 1927, 2845, 2078, 27099, 1930, 20090, 4988, 27099, 1922, 7918, 2687, 5512, 1922, 2132, 1956, 4357, 3]}, "items": [{"id": "p_1018", "content": "Ranitidine [SEP] A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastroin", "score": 1, "type": null, "tokenized_content": [2, 2845, 2078, 27099, 3, 43, 2447, 17, 16045, 14580, 1927, 2690, 14622, 4086, 1988, 8265, 6319, 5512, 12, 4881, 4086, 13, 18, 2176, 1977, 2251, 1942, 2297, 6858, 1921, 3]}]}
{"query": {"id": "q_1019", "content": "cimetidine [SEP] Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecr", "tokenized_content": [2, 20090, 4988, 27099, 3, 3723, 1927, 1920, 6001, 1927, 2845, 2078, 27099, 1930, 20090, 4988, 27099, 1922, 7918, 2687, 5512, 1922, 2132, 1956, 6319, 10694, 1940, 1005, 3]}, "items": [{"id": "p_1019", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_1020", "content": "histamine [SEP] The H2-histamine receptor antagonists ranitidine and cimetidine were compared fo", "tokenized_content": [2, 14622, 3, 1920, 4881, 17, 14622, 3148, 10515, 2845, 2078, 27099, 1930, 20090, 4988, 27099, 1985, 2452, 5917, 3]}, "items": [{"id": "p_1020", "content": "Histamine [SEP] An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of br", "score": 1, "type": null, "tokenized_content": [2, 14622, 3, 1925, 13610, 3595, 2007, 8145, 22429, 1943, 1927, 13873, 18, 2176, 1977, 43, 9974, 24252, 1927, 6319, 5512, 16, 43, 15595, 2684, 1927, 2387, 3]}]}
{"query": {"id": "q_1021", "content": "ranitidine [SEP] The H2-histamine receptor antagonists ranitidine and cimetidine were compared for their abilities to control gas", "tokenized_content": [2, 2845, 2078, 27099, 3, 1920, 4881, 17, 14622, 3148, 10515, 2845, 2078, 27099, 1930, 20090, 4988, 27099, 1985, 2452, 1958, 2310, 10957, 1942, 2285, 4422, 3]}, "items": [{"id": "p_1021", "content": "Ranitidine [SEP] A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastroin", "score": 1, "type": null, "tokenized_content": [2, 2845, 2078, 27099, 3, 43, 2447, 17, 16045, 14580, 1927, 2690, 14622, 4086, 1988, 8265, 6319, 5512, 12, 4881, 4086, 13, 18, 2176, 1977, 2251, 1942, 2297, 6858, 1921, 3]}]}
{"query": {"id": "q_1022", "content": "cimetidine [SEP] The H2-histamine receptor antagonists ranitidine and cimetidine were compared for their abilities to control gastric acid hyper", "tokenized_content": [2, 20090, 4988, 27099, 3, 1920, 4881, 17, 14622, 3148, 10515, 2845, 2078, 27099, 1930, 20090, 4988, 27099, 1985, 2452, 1958, 2310, 10957, 1942, 2285, 6319, 2687, 4194, 3]}, "items": [{"id": "p_1022", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_1023", "content": "Zollinger-Ellison syndrome [SEP]  with gastric acid hypersecretory states. Nineteen patients had Zollinger-Ellison syndrome, one patient had systemic mastocytosis, and two patients had id", "tokenized_content": [2, 21483, 3961, 1915, 17, 20430, 8142, 4741, 3, 1956, 6319, 2687, 10694, 1940, 10411, 2247, 4376, 18, 24354, 2132, 2430, 21483, 3961, 1915, 17, 20430, 8142, 4741, 16, 2340, 2774, 3]}, "items": [{"id": "p_1023", "content": "Zollinger-Ellison Syndrome [SEP] A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumo", "score": 1, "type": null, "tokenized_content": [2, 21483, 3961, 1915, 17, 20430, 8142, 4741, 3, 43, 4741, 1988, 1977, 4378, 2007, 1920, 21845, 1927, 4010, 29488, 10096, 16, 10694, 1940, 10411, 2001, 1927, 6319, 2687, 16, 1930, 27051, 17, 7144, 2497, 1037, 3]}]}
{"query": {"id": "q_1024", "content": "systemic mastocytosis [SEP] neteen patients had Zollinger-Ellison syndrome, one patient had systemic mastocytosis, and two patients had idiopathic hypersecretion. The rates of o", "tokenized_content": [2, 5510, 9731, 7349, 3, 3254, 21115, 2132, 2430, 21483, 3961, 1915, 17, 20430, 8142, 4741, 16, 2340, 2774, 2430, 5510, 9731, 7349, 16, 1930, 2288, 2132, 2430, 13513, 10694, 1940, 3]}, "items": [{"id": "p_1024", "content": "Mastocytosis, Systemic [SEP] A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone ma", "score": 1, "type": null, "tokenized_content": [2, 9731, 7349, 16, 5510, 3, 43, 2210, 1927, 4414, 4189, 2007, 1920, 4552, 4031, 1927, 9731, 2094, 1922, 43, 5386, 1927, 3439, 6909, 3878, 2710, 3622, 2488, 3]}]}
{"query": {"id": "q_1025", "content": "impotence [SEP] tidine). Sixty percent of the males developed breast changes or impotence while taking cimetidine and in all cases these changes disappea", "tokenized_content": [2, 2754, 7229, 15895, 1021, 3, 8685, 27099, 13, 18, 14063, 3564, 1927, 1920, 5129, 3530, 3739, 2840, 2014, 2754, 7229, 15895, 1021, 2679, 6303, 20090, 4988, 27099, 1930, 1922, 2136, 3]}, "items": [{"id": "p_1025", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_1026", "content": "hematologic toxicity [SEP] 1 months; median, 14 months) was not associated with hepatic or hematologic toxicity or alterations of serum gastrin concentrations, but ranitidine ", "tokenized_content": [2, 18251, 5532, 3, 21, 3221, 31, 4181, 16, 2607, 3221, 13, 1982, 2084, 2458, 1956, 6095, 2014, 18251, 5532, 2014, 5996, 1927, 3256, 27051, 3295, 16, 2308, 2845, 2078, 27099, 3]}, "items": [{"id": "p_1026", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_1027", "content": "creatinine [SEP] itidine therapy was associated with a significantly lower serum creatinine level than seen with cimetidine therapy. The results show that ", "tokenized_content": [2, 9374, 3, 2176, 5802, 3181, 1982, 2458, 1956, 43, 2567, 2826, 3256, 9374, 2237, 2254, 3945, 1956, 20090, 4988, 27099, 3181, 18, 1920, 2274, 2146, 1988, 3]}, "items": [{"id": "p_1027", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_1028", "content": "Reye [SEP] A catch in the Reye.", "tokenized_content": [2, 1964, 25047, 3, 43, 14326, 1922, 1920, 1964, 25047, 18, 3]}, "items": [{"id": "p_1028", "content": "Reye Syndrome [SEP] A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progre", "score": 1, "type": null, "tokenized_content": [2, 1964, 25047, 4741, 3, 43, 2386, 1927, 19393, 1956, 5934, 8946, 1927, 1920, 3568, 16, 4378, 2007, 3068, 10144, 1930, 13954, 1988, 2278, 6221, 2745, 1021, 3]}]}
{"query": {"id": "q_1029", "content": "Reye syndrome [SEP] Twenty-six cases of Reye syndrome from The Children's Hospital, Camperdown, Australia, occurring ", "tokenized_content": [2, 1964, 25047, 4741, 3, 7639, 17, 3798, 2919, 1927, 1964, 25047, 4741, 2037, 1920, 3069, 11, 61, 3461, 16, 6225, 1915, 5692, 16, 10014, 16, 6966, 3]}, "items": [{"id": "p_1029", "content": "Reye Syndrome [SEP] A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progre", "score": 1, "type": null, "tokenized_content": [2, 1964, 25047, 4741, 3, 43, 2386, 1927, 19393, 1956, 5934, 8946, 1927, 1920, 3568, 16, 4378, 2007, 3068, 10144, 1930, 13954, 1988, 2278, 6221, 2745, 1021, 3]}]}
{"query": {"id": "q_1030", "content": "Aspirin [SEP] or Disease Control criteria for the diagnosis of Reye syndrome. Aspirin or salicylate ingestion had occurred in only one of the 20 case", "tokenized_content": [2, 12396, 3, 2014, 2573, 2285, 4164, 1958, 1920, 3574, 1927, 1964, 25047, 4741, 18, 12396, 2014, 20734, 9075, 14195, 2430, 4807, 1922, 2444, 2340, 1927, 1920, 2036, 3087, 3]}, "items": [{"id": "p_1030", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_1031", "content": "salicylate [SEP] Control criteria for the diagnosis of Reye syndrome. Aspirin or salicylate ingestion had occurred in only one of the 20 cases (5%), and pa", "tokenized_content": [2, 20734, 9075, 3, 2285, 4164, 1958, 1920, 3574, 1927, 1964, 25047, 4741, 18, 12396, 2014, 20734, 9075, 14195, 2430, 4807, 1922, 2444, 2340, 1927, 1920, 2036, 2919, 12, 25, 9, 3]}, "items": [{"id": "p_1031", "content": "Salicylates [SEP] The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and ", "score": 1, "type": null, "tokenized_content": [2, 20734, 9075, 1036, 3, 1920, 16028, 2014, 16785, 1927, 20734, 14523, 4576, 16, 2014, 20734, 9075, 16785, 1927, 1925, 6805, 2687, 18, 2673, 1927, 2144, 2162, 14501, 16, 2246, 18425, 3023, 16, 1930, 3]}]}
{"query": {"id": "q_1032", "content": "paracetamol [SEP] te ingestion had occurred in only one of the 20 cases (5%), and paracetamol (acetaminophen) had been administered in only six of the cases ", "tokenized_content": [2, 27021, 3, 3602, 14195, 2430, 4807, 1922, 2444, 2340, 1927, 1920, 2036, 2919, 12, 25, 9, 13, 16, 1930, 27021, 12, 23311, 13, 2430, 2252, 5254, 1922, 2444, 3798, 1927, 3]}, "items": [{"id": "p_1032", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_1033", "content": "acetaminophen [SEP] had occurred in only one of the 20 cases (5%), and paracetamol (acetaminophen) had been administered in only six of the cases (30%). Patholog", "tokenized_content": [2, 23311, 3, 2430, 4807, 1922, 2444, 2340, 1927, 1920, 2036, 2919, 12, 25, 9, 13, 16, 1930, 27021, 12, 23311, 13, 2430, 2252, 5254, 1922, 2444, 3798, 1927, 1920, 2919, 3]}, "items": [{"id": "p_1033", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_1034", "content": "aspirin [SEP] rate in the United States. In Australia, the pediatric usage of aspirin has been extremely low for the past 25 years (less than 1% of t", "tokenized_content": [2, 12396, 3, 2769, 1922, 1920, 6128, 4376, 18, 1922, 10014, 16, 1920, 7460, 10070, 1927, 12396, 2258, 2252, 8113, 2330, 1958, 1920, 5375, 2637, 2739, 12, 2941, 2254, 21, 9, 3]}, "items": [{"id": "p_1034", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_1035", "content": "salicylates [SEP] pearing from Australia despite a total lack of association with salicylates or aspirin ingestion, since there were no cases found at The Ch", "tokenized_content": [2, 20734, 9075, 1036, 3, 8893, 1941, 2037, 10014, 4281, 43, 2698, 3630, 1927, 3279, 1956, 20734, 9075, 1036, 2014, 12396, 14195, 16, 3328, 2276, 1985, 2239, 2919, 2435, 2019, 1920, 3]}, "items": [{"id": "p_1035", "content": "Salicylates [SEP] The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and ", "score": 1, "type": null, "tokenized_content": [2, 20734, 9075, 1036, 3, 1920, 16028, 2014, 16785, 1927, 20734, 14523, 4576, 16, 2014, 20734, 9075, 16785, 1927, 1925, 6805, 2687, 18, 2673, 1927, 2144, 2162, 14501, 16, 2246, 18425, 3023, 16, 1930, 3]}]}
{"query": {"id": "q_1036", "content": "St. Anthony's fire [SEP] St. Anthony's fire, then and now: a case report and historical review.", "tokenized_content": [2, 1955, 18, 8795, 14186, 11, 61, 11105, 3, 1955, 18, 8795, 14186, 11, 61, 11105, 16, 2759, 1930, 5195, 30, 43, 3087, 3809, 1930, 12523, 3043, 18, 3]}, "items": [{"id": "p_1036", "content": "Ergotism [SEP] Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11949, 13323, 18538, 3, 18722, 4189, 2007, 11378, 2104, 11949, 13323, 6756, 11572, 2014, 2007, 1920, 5682, 7408, 19884, 2014, 9122, 2485, 1927, 11949, 1991, 1966, 43, 5380, 18, 3]}]}
{"query": {"id": "q_1037", "content": "vasospasm [SEP] A rare case of morbid vasospasm, together with striking angiographic findings, is described sec", "tokenized_content": [2, 22866, 3508, 2691, 3, 43, 5844, 3087, 1927, 14296, 22866, 3508, 2691, 16, 4084, 1956, 9784, 22626, 3056, 16, 1977, 2910, 2532, 3]}, "items": [{"id": "p_1037", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_1038", "content": "methysergide [SEP] giographic findings, is described secondary to the ingestion of methysergide by a 48-year-old woman. A brief review of the literature on sim", "tokenized_content": [2, 2295, 2012, 2693, 2261, 3, 7217, 4158, 3056, 16, 1977, 2910, 4067, 1942, 1920, 14195, 1927, 2295, 2012, 2693, 2261, 2007, 43, 3427, 17, 2476, 17, 4156, 10440, 18, 43, 3]}, "items": [{"id": "p_1038", "content": "Methysergide [SEP] An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels a", "score": 1, "type": null, "tokenized_content": [2, 2295, 2012, 2693, 2261, 3, 1925, 11949, 1991, 10533, 1988, 1977, 43, 8680, 1915, 1927, 3629, 5237, 2687, 18622, 5482, 18, 2176, 28104, 1036, 1920, 2564, 1927, 11153, 1922, 2877, 7208, 43, 3]}]}
{"query": {"id": "q_1039", "content": "ergot [SEP] e on similar cases is presented. A discussion of the history of ergot includes its original discovery, the epidemics of gangrene that", "tokenized_content": [2, 11949, 1991, 3, 47, 1990, 2551, 2919, 1977, 3549, 18, 43, 7248, 1927, 1920, 4403, 1927, 11949, 1991, 5921, 2496, 5538, 7139, 16, 1920, 22190, 1927, 16249, 26774, 1021, 1988, 3]}, "items": [{"id": "p_1039", "content": "Ergot Alkaloids [SEP] Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structura", "score": 1, "type": null, "tokenized_content": [2, 11949, 1991, 22390, 3, 22390, 10398, 3937, 2037, 1920, 11949, 1991, 16461, 19887, 2927, 2523, 25945, 16648, 12, 20956, 1936, 9914, 13, 18, 2611, 3951, 4300, 1988, 2032, 2581, 9280, 3]}]}
{"query": {"id": "q_1040", "content": "gangrene [SEP] tory of ergot includes its original discovery, the epidemics of gangrene that it has caused through the ages and its past and present ro", "tokenized_content": [2, 16249, 26774, 1021, 3, 8184, 1012, 1927, 11949, 1991, 5921, 2496, 5538, 7139, 16, 1920, 22190, 1927, 16249, 26774, 1021, 1988, 2176, 2258, 4189, 2596, 1920, 7684, 1930, 2496, 5375, 3]}, "items": [{"id": "p_1040", "content": "Gangrene [SEP] Death and putrefaction of tissue usually due to a loss of blood supply.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16249, 26774, 1021, 3, 3539, 1930, 5366, 24864, 2314, 1927, 2960, 5394, 2810, 1942, 43, 3257, 1927, 2877, 9042, 18, 3]}]}
{"query": {"id": "q_1041", "content": "migraine headache [SEP] ugh the ages and its past and present role in the management of migraine headache. Despite the advent of calcium channel blockers and beta-adrene", "tokenized_content": [2, 13258, 12187, 3, 12522, 1023, 1920, 7684, 1930, 2496, 5375, 1930, 2481, 2770, 1922, 1920, 4280, 1927, 13258, 12187, 18, 4281, 1920, 20873, 1927, 5016, 4999, 13628, 1930, 4666, 17, 3]}, "items": [{"id": "p_1041", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_1042", "content": "calcium [SEP] e in the management of migraine headache. Despite the advent of calcium channel blockers and beta-adrenergic antagonists, ergot prepara", "tokenized_content": [2, 5016, 3, 47, 1922, 1920, 4280, 1927, 13258, 12187, 18, 4281, 1920, 20873, 1927, 5016, 4999, 13628, 1930, 4666, 17, 13672, 10515, 16, 11949, 1991, 3524, 1019, 3]}, "items": [{"id": "p_1042", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1043", "content": "migraine [SEP] ugh the ages and its past and present role in the management of migraine headache. Despite the advent of calcium channel blockers and be", "tokenized_content": [2, 13258, 3, 12522, 1023, 1920, 7684, 1930, 2496, 5375, 1930, 2481, 2770, 1922, 1920, 4280, 1927, 13258, 12187, 18, 4281, 1920, 20873, 1927, 5016, 4999, 13628, 1930, 1998, 3]}, "items": [{"id": "p_1043", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_1044", "content": "St. Anthony's fire [SEP] to play a major role in migraine therapy, so that the danger of St. Anthony's fire persists.", "tokenized_content": [2, 1955, 18, 8795, 14186, 11, 61, 11105, 3, 1942, 3918, 43, 3044, 2770, 1922, 13258, 3181, 16, 2577, 1988, 1920, 15378, 1927, 1955, 18, 8795, 14186, 11, 61, 11105, 20350, 3]}, "items": [{"id": "p_1044", "content": "Ergotism [SEP] Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11949, 13323, 18538, 3, 18722, 4189, 2007, 11378, 2104, 11949, 13323, 6756, 11572, 2014, 2007, 1920, 5682, 7408, 19884, 2014, 9122, 2485, 1927, 11949, 1991, 1966, 43, 5380, 18, 3]}]}
{"query": {"id": "q_1045", "content": "hypokalemia [SEP] Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol.", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 4666, 17, 22, 17, 25090, 17, 3434, 14395, 7640, 1952, 6026, 1930, 2496, 18741, 2017, 2007, 2833, 20367, 23646, 18, 3]}, "items": [{"id": "p_1045", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1046", "content": "oxprenolol [SEP] Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol.", "tokenized_content": [2, 2833, 20367, 23646, 3, 4666, 17, 22, 17, 25090, 17, 3434, 14395, 7640, 1952, 6026, 1930, 2496, 18741, 2017, 2007, 2833, 20367, 23646, 18, 3]}, "items": [{"id": "p_1046", "content": "Oxprenolol [SEP] A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2833, 20367, 23646, 3, 43, 4666, 17, 13672, 8151, 2251, 1922, 1920, 2311, 1927, 5579, 16, 16961, 23540, 1937, 16, 16934, 16, 1930, 5592, 18, 3]}]}
{"query": {"id": "q_1047", "content": "terbutaline [SEP] The time course and concentration-effect relationship of terbutaline-induced hypokalemia was studied, using computer-aided pharmacok", "tokenized_content": [2, 6005, 16119, 8177, 3, 1920, 2367, 4914, 1930, 3110, 17, 2495, 3303, 1927, 6005, 16119, 8177, 17, 2719, 14395, 7640, 1952, 6026, 1982, 3942, 16, 2193, 7058, 17, 20037, 4602, 3]}, "items": [{"id": "p_1047", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_1048", "content": "hypokalemia [SEP] se and concentration-effect relationship of terbutaline-induced hypokalemia was studied, using computer-aided pharmacokinetic-dynamic model", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 2058, 1930, 3110, 17, 2495, 3303, 1927, 6005, 16119, 8177, 17, 2719, 14395, 7640, 1952, 6026, 1982, 3942, 16, 2193, 7058, 17, 20037, 12763, 17, 3]}, "items": [{"id": "p_1048", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1049", "content": "oxprenolol [SEP] -dynamic modeling. Subsequently we investigated the efficacy of oxprenolol in antagonizing such hypokalemia, together with the pharmacokin", "tokenized_content": [2, 2833, 20367, 23646, 3, 17, 5760, 7081, 18, 5326, 2038, 3845, 1920, 4348, 1927, 2833, 20367, 23646, 1922, 5605, 3903, 2427, 14395, 7640, 1952, 6026, 16, 4084, 1956, 1920, 4602, 3]}, "items": [{"id": "p_1049", "content": "Oxprenolol [SEP] A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2833, 20367, 23646, 3, 43, 4666, 17, 13672, 8151, 2251, 1922, 1920, 2311, 1927, 5579, 16, 16961, 23540, 1937, 16, 16934, 16, 1930, 5592, 18, 3]}]}
{"query": {"id": "q_1050", "content": "potassium [SEP] stration, plasma samples were taken for determination of plasma potassium levels and drug concentrations. The sigmoid Emax model offered ", "tokenized_content": [2, 9057, 3, 9402, 1929, 16, 3582, 2785, 1985, 4208, 1958, 7063, 1927, 3582, 9057, 2428, 1930, 2838, 3295, 18, 1920, 21205, 23444, 1039, 2322, 10318, 3]}, "items": [{"id": "p_1050", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1051", "content": "Oxprenolol [SEP] ation between terbutaline concentrations and potassium effects. Oxprenolol caused decreases of 65% and 56% of terbutaline volume of distri", "tokenized_content": [2, 2833, 20367, 23646, 3, 2019, 2001, 2192, 6005, 16119, 8177, 3295, 1930, 9057, 2564, 18, 2833, 20367, 23646, 4189, 6386, 1927, 4459, 9, 1930, 4489, 9, 1927, 6005, 16119, 8177, 3]}, "items": [{"id": "p_1051", "content": "Oxprenolol [SEP] A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2833, 20367, 23646, 3, 43, 4666, 17, 13672, 8151, 2251, 1922, 1920, 2311, 1927, 5579, 16, 16961, 23540, 1937, 16, 16934, 16, 1930, 5592, 18, 3]}]}
{"query": {"id": "q_1052", "content": "serotonin [SEP] Midline B3 serotonin nerves in rat medulla are involved in hypotensive effect of met", "tokenized_content": [2, 11153, 3, 14210, 16563, 11153, 12014, 1922, 3067, 18755, 2032, 3286, 1922, 12201, 3766, 2495, 1927, 2130, 3]}, "items": [{"id": "p_1052", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1053", "content": "hypotensive [SEP] Midline B3 serotonin nerves in rat medulla are involved in hypotensive effect of methyldopa.", "tokenized_content": [2, 12201, 3766, 3, 14210, 16563, 11153, 12014, 1922, 3067, 18755, 2032, 3286, 1922, 12201, 3766, 2495, 1927, 4963, 22389, 4302, 18, 3]}, "items": [{"id": "p_1053", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1054", "content": "methyldopa [SEP] nin nerves in rat medulla are involved in hypotensive effect of methyldopa.", "tokenized_content": [2, 4963, 22389, 4302, 3, 12117, 12014, 1922, 3067, 18755, 2032, 3286, 1922, 12201, 3766, 2495, 1927, 4963, 22389, 4302, 18, 3]}, "items": [{"id": "p_1054", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_1055", "content": "methyldopa [SEP] xperiments in this laboratory have shown that microinjection of methyldopa onto the ventrolateral cells of the B3 serotonin neurons in the", "tokenized_content": [2, 4963, 22389, 4302, 3, 15930, 18842, 2560, 1922, 2052, 4542, 2162, 2522, 1988, 24283, 1927, 4963, 22389, 4302, 6131, 1920, 30429, 2094, 1927, 1920, 16563, 11153, 3558, 1922, 1920, 3]}, "items": [{"id": "p_1055", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_1056", "content": "serotonin [SEP] oinjection of methyldopa onto the ventrolateral cells of the B3 serotonin neurons in the medulla elicits a hypotensive response mediated ", "tokenized_content": [2, 11153, 3, 25166, 1022, 7931, 1927, 4963, 22389, 4302, 6131, 1920, 30429, 2094, 1927, 1920, 16563, 11153, 3558, 1922, 1920, 18755, 21809, 43, 12201, 3766, 2644, 3434, 3]}, "items": [{"id": "p_1056", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1057", "content": "hypotensive [SEP] eral cells of the B3 serotonin neurons in the medulla elicits a hypotensive response mediated by a projection descending into the spinal co", "tokenized_content": [2, 12201, 3766, 3, 14821, 1024, 2094, 1927, 1920, 16563, 11153, 3558, 1922, 1920, 18755, 21809, 43, 12201, 3766, 2644, 3434, 2007, 43, 11244, 14931, 2460, 1920, 6071, 2081, 3]}, "items": [{"id": "p_1057", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1058", "content": "hypertensive [SEP] the medulla, coinciding with the raphe magnus. In spontaneously hypertensive, stroke-prone rats, microinjection of methyldopa into the area ", "tokenized_content": [2, 11706, 3, 1920, 18755, 16, 10420, 11353, 1956, 1920, 27106, 3679, 1957, 18, 1922, 12753, 11706, 16, 5235, 17, 10424, 3615, 16, 24283, 1927, 4963, 22389, 4302, 2460, 1920, 3403, 3]}, "items": [{"id": "p_1058", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1059", "content": "stroke [SEP] oinciding with the raphe magnus. In spontaneously hypertensive, stroke-prone rats, microinjection of methyldopa into the area of the m", "tokenized_content": [2, 5235, 3, 25166, 15895, 11353, 1956, 1920, 27106, 3679, 1957, 18, 1922, 12753, 11706, 16, 5235, 17, 10424, 3615, 16, 24283, 1927, 4963, 22389, 4302, 2460, 1920, 3403, 1927, 1920, 3]}, "items": [{"id": "p_1059", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1060", "content": "hypotension [SEP]  B3 serotonin cell group in the ventral medulla caused a potent hypotension of 30-40 mm Hg, which was maximal 2-3 h after administration an", "tokenized_content": [2, 16453, 3, 16563, 11153, 2024, 2210, 1922, 1920, 8420, 18755, 4189, 43, 6828, 16453, 1927, 2627, 17, 3040, 2489, 7175, 16, 2154, 1982, 7275, 22, 17, 23, 50, 2256, 4183, 3]}, "items": [{"id": "p_1060", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1061", "content": "5,7-dihydroxytryptamine [SEP] er administration and was abolished by the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) injected intracerebroventricularly. However, intraspi", "tokenized_content": [2, 25, 16, 27, 17, 20684, 30298, 3812, 3, 2668, 4183, 1930, 1982, 10979, 2007, 1920, 11153, 9124, 9754, 25, 16, 27, 17, 20684, 30298, 3812, 12, 25, 16, 27, 17, 3]}, "items": [{"id": "p_1061", "content": "5,7-Dihydroxytryptamine [SEP] Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotone", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 27, 17, 20684, 30298, 3812, 3, 11790, 3812, 11798, 1956, 2288, 9420, 2671, 1922, 6490, 25, 1930, 27, 18, 2176, 1977, 43, 20919, 11153, 5729, 1988, 19259, 1036, 9752, 2290, 3]}]}
{"query": {"id": "q_1062", "content": "5,7-DHT [SEP]  abolished by the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) injected intracerebroventricularly. However, intraspinal injec", "tokenized_content": [2, 25, 16, 27, 17, 22379, 3, 10979, 2007, 1920, 11153, 9124, 9754, 25, 16, 27, 17, 20684, 30298, 3812, 12, 25, 16, 27, 17, 22379, 13, 5624, 19343, 18474, 24722, 3]}, "items": [{"id": "p_1062", "content": "5,7-Dihydroxytryptamine [SEP] Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotone", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 27, 17, 20684, 30298, 3812, 3, 11790, 3812, 11798, 1956, 2288, 9420, 2671, 1922, 6490, 25, 1930, 27, 18, 2176, 1977, 43, 20919, 11153, 5729, 1988, 19259, 1036, 9752, 2290, 3]}]}
{"query": {"id": "q_1063", "content": "Yohimbine [SEP] Yohimbine treatment of sexual side effects induced by serotonin reuptake ", "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 7419, 7969, 17010, 2053, 2311, 1927, 5702, 4159, 2564, 2719, 2007, 11153, 22957, 3]}, "items": [{"id": "p_1063", "content": "Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT", "score": 1, "type": null, "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 43, 4496, 29951, 1956, 4595, 17, 22, 17, 13672, 7472, 2455, 18, 7419, 7969, 17010, 2053, 2258, 2252, 2251, 1966, 43, 15388, 3027, 2479, 1930, 1922, 1920, 2311, 1927, 24311, 1031, 3]}]}
{"query": {"id": "q_1064", "content": "sexual side effects [SEP] Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers.", "tokenized_content": [2, 5702, 4159, 2564, 3, 7419, 7969, 17010, 2053, 2311, 1927, 5702, 4159, 2564, 2719, 2007, 11153, 22957, 13628, 18, 3]}, "items": [{"id": "p_1064", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_1065", "content": "serotonin [SEP] Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers.", "tokenized_content": [2, 11153, 3, 7419, 7969, 17010, 2053, 2311, 1927, 5702, 4159, 2564, 2719, 2007, 11153, 22957, 13628, 18, 3]}, "items": [{"id": "p_1065", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1066", "content": "yohimbine [SEP] BACKGROUND: Preclinical and clinical studies suggest that yohimbine facilitates sexual behavior and may be helpful in the treatment", "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 3872, 30, 10311, 1930, 2535, 2351, 3220, 1988, 7419, 7969, 17010, 2053, 11374, 5702, 3379, 1930, 2278, 1998, 9617, 1922, 1920, 2311, 3]}, "items": [{"id": "p_1066", "content": "Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT", "score": 1, "type": null, "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 43, 4496, 29951, 1956, 4595, 17, 22, 17, 13672, 7472, 2455, 18, 7419, 7969, 17010, 2053, 2258, 2252, 2251, 1966, 43, 15388, 3027, 2479, 1930, 1922, 1920, 2311, 1927, 24311, 1031, 3]}]}
{"query": {"id": "q_1067", "content": "male impotence [SEP] ilitates sexual behavior and may be helpful in the treatment of male impotence. A single case report suggests that yohimbine may be used to tr", "tokenized_content": [2, 4005, 2754, 7229, 15895, 1021, 3, 14872, 3857, 14652, 5702, 3379, 1930, 2278, 1998, 9617, 1922, 1920, 2311, 1927, 4005, 2754, 7229, 15895, 1021, 18, 43, 2957, 3087, 3809, 4015, 3]}, "items": [{"id": "p_1067", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_1068", "content": "sexual side effects [SEP] le case report suggests that yohimbine may be used to treat the sexual side effects of clomipramine. This study evaluated yohimbine as a treatment ", "tokenized_content": [2, 5702, 4159, 2564, 3, 2071, 3087, 3809, 4015, 1988, 7419, 7969, 17010, 2053, 2278, 1998, 2251, 1942, 2297, 1920, 5702, 4159, 2564, 1927, 12596, 7395, 13399, 25157, 18, 2052, 2161, 3]}, "items": [{"id": "p_1068", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_1069", "content": "clomipramine [SEP]  that yohimbine may be used to treat the sexual side effects of clomipramine. This study evaluated yohimbine as a treatment for the sexual s", "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 1988, 7419, 7969, 17010, 2053, 2278, 1998, 2251, 1942, 2297, 1920, 5702, 4159, 2564, 1927, 12596, 7395, 13399, 25157, 18, 2052, 2161, 3747, 7419, 7969, 3]}, "items": [{"id": "p_1069", "content": "Clomipramine [SEP] A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily a", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 43, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 1988, 9331, 7042, 1920, 5047, 1927, 11153, 1922, 1920, 3068, 18, 2176, 1977, 8745, 43, 3]}]}
{"query": {"id": "q_1070", "content": "serotonin [SEP]  yohimbine as a treatment for the sexual side effects caused by serotonin reuptake blockers. METHOD: Six patients with either obsessive c", "tokenized_content": [2, 11153, 3, 7419, 7969, 17010, 2053, 1966, 43, 2311, 1958, 1920, 5702, 4159, 2564, 4189, 2007, 11153, 22957, 13628, 18, 2417, 30, 3798, 2132, 1956, 3108, 25555, 45, 3]}, "items": [{"id": "p_1070", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1071", "content": "obsessive compulsive disorder [SEP] y serotonin reuptake blockers. METHOD: Six patients with either obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered", "tokenized_content": [2, 25555, 21543, 4770, 3, 67, 11153, 22957, 13628, 18, 2417, 30, 3798, 2132, 1956, 3108, 25555, 21543, 4770, 16, 10477, 13323, 11560, 8678, 2126, 16, 5592, 16, 2014, 11863, 4414, 3]}, "items": [{"id": "p_1071", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_1072", "content": "trichotillomania [SEP] METHOD: Six patients with either obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered sexual side effec", "tokenized_content": [2, 10477, 13323, 11560, 8678, 2126, 3, 2417, 30, 3798, 2132, 1956, 3108, 25555, 21543, 4770, 16, 10477, 13323, 11560, 8678, 2126, 16, 5592, 16, 2014, 11863, 4414, 2746, 13949, 5702, 3]}, "items": [{"id": "p_1072", "content": "Trichotillomania [SEP] Compulsion to pull out one's hair.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10477, 13323, 11560, 8678, 2126, 3, 2059, 12138, 1942, 10875, 2397, 2340, 11, 61, 7018, 18, 3]}]}
{"query": {"id": "q_1073", "content": "anxiety [SEP] ts with either obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered sexual side effects after ", "tokenized_content": [2, 5592, 3, 4894, 1956, 3108, 25555, 21543, 4770, 16, 10477, 13323, 11560, 8678, 2126, 16, 5592, 16, 2014, 11863, 4414, 2746, 13949, 5702, 4159, 2564, 2256, 3]}, "items": [{"id": "p_1073", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_1074", "content": "affective disorders [SEP] er obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered sexual side effects after treatment with serotonin", "tokenized_content": [2, 11863, 4414, 3, 2668, 25555, 21543, 4770, 16, 10477, 13323, 11560, 8678, 2126, 16, 5592, 16, 2014, 11863, 4414, 2746, 13949, 5702, 4159, 2564, 2256, 2311, 1956, 11153, 3]}, "items": [{"id": "p_1074", "content": "Mood Disorders [SEP] Those disorders that have a disturbance in mood as their predominant feature.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9494, 4414, 3, 2690, 4414, 1988, 2162, 43, 12732, 1922, 9494, 1966, 2310, 6136, 5961, 18, 3]}]}
{"query": {"id": "q_1075", "content": "Hypersensitivity [SEP] Hypersensitivity immune reaction as a mechanism for dilevalol-associated hepatit", "tokenized_content": [2, 14625, 3, 14625, 3743, 3227, 1966, 43, 2856, 1958, 22124, 4701, 1945, 17, 2458, 5746, 1932, 3]}, "items": [{"id": "p_1075", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1076", "content": "dilevalol [SEP] Hypersensitivity immune reaction as a mechanism for dilevalol-associated hepatitis.", "tokenized_content": [2, 22124, 4701, 1945, 3, 14625, 3743, 3227, 1966, 43, 2856, 1958, 22124, 4701, 1945, 17, 2458, 7977, 18, 3]}, "items": [{"id": "p_1076", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_1077", "content": "hepatitis [SEP] itivity immune reaction as a mechanism for dilevalol-associated hepatitis.", "tokenized_content": [2, 7977, 3, 2176, 10794, 3743, 3227, 1966, 43, 2856, 1958, 22124, 4701, 1945, 17, 2458, 7977, 18, 3]}, "items": [{"id": "p_1077", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1078", "content": "dilevalol [SEP] OBJECTIVE: To assess lymphocyte reactivity to dilevalol and to serum containing putative ex vivo dilevalol antigens or ", "tokenized_content": [2, 22124, 4701, 1945, 3, 4470, 30, 1942, 2634, 10009, 8229, 1942, 22124, 4701, 1945, 1930, 1942, 3256, 3165, 6770, 1975, 3597, 22124, 4701, 1945, 7769, 2014, 3]}, "items": [{"id": "p_1078", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_1079", "content": "liver injury [SEP] ilevalol antigens or metabolites in a case of dilevalol-induced liver injury. PATIENT: A 58-year-old woman with a clinical diagnosis of dile", "tokenized_content": [2, 3568, 4047, 3, 9940, 4701, 1945, 7769, 2014, 6926, 1922, 43, 3087, 1927, 22124, 4701, 1945, 17, 2719, 3568, 4047, 18, 2774, 30, 43, 4804, 17, 2476, 17, 4156, 10440, 3]}, "items": [{"id": "p_1079", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1080", "content": "myocardial hypertrophy [SEP] Reversible myocardial hypertrophy induced by tacrolimus in a pediatric heart transplant recipient", "tokenized_content": [2, 6497, 11014, 3, 10743, 6497, 11014, 2719, 2007, 21801, 1922, 43, 7460, 4003, 5192, 10664, 3]}, "items": [{"id": "p_1080", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_1081", "content": "tacrolimus [SEP] Reversible myocardial hypertrophy induced by tacrolimus in a pediatric heart transplant recipient: case report.", "tokenized_content": [2, 21801, 3, 10743, 6497, 11014, 2719, 2007, 21801, 1922, 43, 7460, 4003, 5192, 10664, 30, 3087, 3809, 18, 3]}, "items": [{"id": "p_1081", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1082", "content": "Tacrolimus [SEP] Tacrolimus is a potent immunosuppressant that is frequently used in organ ", "tokenized_content": [2, 21801, 3, 21801, 1977, 43, 6828, 27996, 2031, 1988, 1977, 5467, 2251, 1922, 3090, 3]}, "items": [{"id": "p_1082", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1083", "content": "cardiac toxicity [SEP] used in organ transplantation. However, adverse effects include cardiac toxicity. Herein we describe transient myocardial hypertrophy induced by", "tokenized_content": [2, 4435, 5532, 3, 2251, 1922, 3090, 6530, 18, 2406, 16, 5246, 2564, 3951, 4435, 5532, 18, 10388, 2038, 5993, 6809, 6497, 11014, 2719, 2007, 3]}, "items": [{"id": "p_1083", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_1084", "content": "myocardial hypertrophy [SEP]  effects include cardiac toxicity. Herein we describe transient myocardial hypertrophy induced by tacrolimus after heart transplantation. The hypertro", "tokenized_content": [2, 6497, 11014, 3, 2564, 3951, 4435, 5532, 18, 10388, 2038, 5993, 6809, 6497, 11014, 2719, 2007, 21801, 2256, 4003, 6530, 18, 1920, 4506, 1931, 3]}, "items": [{"id": "p_1084", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_1085", "content": "tacrolimus [SEP]  Herein we describe transient myocardial hypertrophy induced by tacrolimus after heart transplantation. The hypertrophy caused no clinical", "tokenized_content": [2, 21801, 3, 10388, 2038, 5993, 6809, 6497, 11014, 2719, 2007, 21801, 2256, 4003, 6530, 18, 1920, 11014, 4189, 2239, 2535, 3]}, "items": [{"id": "p_1085", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1086", "content": "hypertrophy [SEP] clude cardiac toxicity. Herein we describe transient myocardial hypertrophy induced by tacrolimus after heart transplantation. The hypertro", "tokenized_content": [2, 11014, 3, 2111, 3424, 4435, 5532, 18, 10388, 2038, 5993, 6809, 6497, 11014, 2719, 2007, 21801, 2256, 4003, 6530, 18, 1920, 4506, 1931, 3]}, "items": [{"id": "p_1086", "content": "Hypertrophy [SEP] General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor ", "score": 1, "type": null, "tokenized_content": [2, 11014, 3, 3335, 2760, 1922, 9390, 1927, 43, 3131, 2014, 3090, 2810, 1942, 2024, 16363, 1930, 4858, 1927, 13315, 1930, 21417, 16, 2084, 2810, 1942, 2798, 3]}]}
{"query": {"id": "q_1087", "content": "edema [SEP] ; however, myocardial biopsy samples revealed only interstitial edema and mild myocardial hypertrophy; neither cellular nor humoral r", "tokenized_content": [2, 10144, 3, 31, 2406, 16, 6497, 6831, 2785, 3404, 2444, 11584, 10144, 1930, 5809, 6497, 11014, 31, 7132, 3689, 3990, 16601, 60, 3]}, "items": [{"id": "p_1087", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_1088", "content": "Myocardial hypertrophy [SEP] r than usual at that time; thus, tacrolimus dosage was reduced. Myocardial hypertrophy completely resolved upon reducing the target concentration of t", "tokenized_content": [2, 6497, 11014, 3, 60, 2254, 10616, 2019, 1988, 2367, 31, 2842, 16, 21801, 9998, 1982, 3028, 18, 6497, 11014, 5796, 8397, 4073, 5526, 1920, 2758, 3110, 1927, 62, 3]}, "items": [{"id": "p_1088", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_1089", "content": "idiopathic Parkinson's disease [SEP]  unilateral pallidotomy and subthalamotomy findings in advanced idiopathic Parkinson's disease.", "tokenized_content": [2, 13513, 10124, 11, 61, 2573, 3, 12059, 12574, 22389, 4575, 14930, 1930, 21652, 7010, 9753, 3056, 1922, 5570, 13513, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_1089", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1090", "content": "idiopathic Parkinson's disease [SEP] reotactic unilateral pallidotomy and subthalamotomy in advanced idiopathic Parkinson's disease (PD) refractory to medical treatment was designed. Ten consecut", "tokenized_content": [2, 13513, 10124, 11, 61, 2573, 3, 1964, 7336, 2341, 1935, 12059, 12574, 22389, 4575, 14930, 1930, 21652, 7010, 9753, 1922, 5570, 13513, 10124, 11, 61, 2573, 12, 3203, 13, 10923, 3]}, "items": [{"id": "p_1090", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1091", "content": "PD [SEP]  and subthalamotomy in advanced idiopathic Parkinson's disease (PD) refractory to medical treatment was designed. Ten consecutive ", "tokenized_content": [2, 3203, 3, 1930, 21652, 7010, 9753, 1922, 5570, 13513, 10124, 11, 61, 2573, 12, 3203, 13, 10923, 1942, 3423, 2311, 1982, 4609, 18, 5656, 7351, 3]}, "items": [{"id": "p_1091", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1092", "content": "levodopa [SEP] or fluctuations (Hoehn _ Yahr stage 3-5 in off-drug phases) and levodopa-induced dyskinesias were selected. All patients had bilateral s", "tokenized_content": [2, 26723, 3, 2014, 11429, 12, 6673, 29586, 1022, 41, 26169, 6570, 3587, 23, 17, 25, 1922, 4013, 17, 2838, 7643, 13, 1930, 26723, 17, 2719, 3890, 26682, 1036, 1985, 3790, 3]}, "items": [{"id": "p_1092", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_1093", "content": "dyskinesias [SEP] Hoehn _ Yahr stage 3-5 in off-drug phases) and levodopa-induced dyskinesias were selected. All patients had bilateral symptoms and their le", "tokenized_content": [2, 3890, 26682, 1036, 3, 6673, 29586, 1022, 41, 26169, 6570, 3587, 23, 17, 25, 1922, 4013, 17, 2838, 7643, 13, 1930, 26723, 17, 2719, 3890, 26682, 1036, 1985, 3790, 18, 3]}, "items": [{"id": "p_1093", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1094", "content": "Parkinson's Disease [SEP] leus (STN). Clinical evaluation included the use of the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn_Yahr score and Schwab England activ", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 10632, 1036, 12, 21667, 13, 18, 2535, 4391, 3063, 1920, 2485, 1927, 1920, 21281, 10124, 11, 61, 2573, 7276, 3536, 12, 8831, 5675, 13, 16, 3]}, "items": [{"id": "p_1094", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1095", "content": "parkinsonian [SEP] tatistically significant improvement in all contralateral major parkinsonian motor signs in all patients followed for 6 months. Levodopa equ", "tokenized_content": [2, 10124, 3122, 3, 10687, 12625, 2228, 4990, 1922, 2136, 10906, 3044, 10124, 3122, 4842, 6879, 1922, 2136, 2132, 3489, 1958, 26, 3221, 18, 26723, 3009, 3]}, "items": [{"id": "p_1095", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1096", "content": "Levodopa [SEP] parkinsonian motor signs in all patients followed for 6 months. Levodopa equivalent daily intake was significantly reduced in the STN gr", "tokenized_content": [2, 26723, 3, 10124, 3122, 4842, 6879, 1922, 2136, 2132, 3489, 1958, 26, 3221, 18, 26723, 6582, 4692, 5240, 1982, 2567, 3028, 1922, 1920, 21667, 2398, 3]}, "items": [{"id": "p_1096", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_1097", "content": "homonymous hemianopsia [SEP] ps. Complications were observed in two patients: one had a left homonymous hemianopsia after pallidotomy and another one developed left hemiballistic ", "tokenized_content": [2, 16350, 16323, 12492, 1957, 28881, 9286, 14149, 3, 2742, 18, 5021, 1985, 2528, 1922, 2288, 2132, 30, 2340, 2430, 43, 3506, 16350, 16323, 12492, 1957, 28881, 9286, 14149, 2256, 12574, 3]}, "items": [{"id": "p_1097", "content": "Hemianopsia [SEP] Partial or complete loss of vision in one half of the visual field(s) of one or both eyes. Subtypes include altitudinal hemianop", "score": 1, "type": null, "tokenized_content": [2, 28881, 9286, 14149, 3, 5740, 2014, 4080, 3257, 1927, 9266, 1922, 2340, 4768, 1927, 1920, 3737, 3559, 12, 61, 13, 1927, 2340, 2014, 2321, 7127, 18, 8160, 3951, 8387, 5629, 2526, 28881, 9286, 1034, 3]}]}
{"query": {"id": "q_1098", "content": "Valproate [SEP]  after subthalamotomy which partly improved within 1 month with Valproate 1000 mg/day. The findings of this study suggest that lesions of", "tokenized_content": [2, 23867, 2010, 3, 2256, 21652, 7010, 9753, 2154, 10028, 4305, 2651, 21, 2935, 1956, 23867, 2010, 5672, 2786, 19, 3007, 18, 1920, 3056, 1927, 2052, 2161, 3220, 1988, 4518, 1927, 3]}, "items": [{"id": "p_1098", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1099", "content": "puromycin aminonucleoside [SEP] Protective effects of antithrombin on puromycin aminonucleoside nephrosis in rats.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 6337, 2564, 1927, 10310, 6570, 10123, 1921, 1990, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 1922, 3615, 18, 3]}, "items": [{"id": "p_1099", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_1100", "content": "nephrosis [SEP] Protective effects of antithrombin on puromycin aminonucleoside nephrosis in rats.", "tokenized_content": [2, 7737, 4870, 3, 6337, 2564, 1927, 10310, 6570, 10123, 1921, 1990, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 1922, 3615, 18, 3]}, "items": [{"id": "p_1100", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_1101", "content": "puromycin aminonucleoside [SEP] rombin, a plasma inhibitor of coagulation factors, in rats with puromycin aminonucleoside-induced nephrosis, which is an experimental model of human neph", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 15612, 23605, 16, 43, 3582, 4106, 1927, 12441, 2790, 16, 1922, 3615, 1956, 19750, 3835, 1022, 2626, 8028, 17, 2719, 7737, 4870, 16, 2154, 3]}, "items": [{"id": "p_1101", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_1102", "content": "nephrosis [SEP] ulation factors, in rats with puromycin aminonucleoside-induced nephrosis, which is an experimental model of human nephrotic syndrome. An", "tokenized_content": [2, 7737, 4870, 3, 3570, 1943, 2790, 16, 1922, 3615, 1956, 19750, 3835, 1022, 2626, 8028, 17, 2719, 7737, 4870, 16, 2154, 1977, 1925, 3599, 2322, 1927, 2616, 29646, 4741, 18, 3]}, "items": [{"id": "p_1102", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_1103", "content": "nephrotic syndrome [SEP] side-induced nephrosis, which is an experimental model of human nephrotic syndrome. Antithrombin (50 or 500 IU/kg/i.v.) was administered to rats o", "tokenized_content": [2, 29646, 4741, 3, 4159, 17, 2719, 7737, 4870, 16, 2154, 1977, 1925, 3599, 2322, 1927, 2616, 29646, 4741, 18, 10310, 6570, 10123, 1921, 12, 2761, 2014, 4599, 11176, 19, 3621, 3]}, "items": [{"id": "p_1103", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_1104", "content": "hematological abnormalities [SEP] h antithrombin attenuated the puromycin aminonucleoside-induced hematological abnormalities. Puromycin aminonucleoside-induced renal dysfunction and hyperl", "tokenized_content": [2, 17339, 6754, 3, 50, 10310, 6570, 10123, 1921, 8060, 1920, 19750, 3835, 1022, 2626, 8028, 17, 2719, 17339, 6754, 18, 19750, 3835, 1022, 2626, 8028, 17, 2719, 4604, 5273, 1930, 3]}, "items": [{"id": "p_1104", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_1105", "content": "Puromycin aminonucleoside [SEP]  puromycin aminonucleoside-induced hematological abnormalities. Puromycin aminonucleoside-induced renal dysfunction and hyperlipidemia were also suppress", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 3835, 1022, 2626, 8028, 17, 2719, 17339, 6754, 18, 19750, 3835, 1022, 2626, 8028, 17, 2719, 4604, 5273, 1930, 21381, 1985, 2222, 4400, 3]}, "items": [{"id": "p_1105", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_1106", "content": "renal dysfunction [SEP]  hematological abnormalities. Puromycin aminonucleoside-induced renal dysfunction and hyperlipidemia were also suppressed. Histopathological exam", "tokenized_content": [2, 4604, 5273, 3, 17339, 6754, 18, 19750, 3835, 1022, 2626, 8028, 17, 2719, 4604, 5273, 1930, 21381, 1985, 2222, 7657, 18, 11777, 2493, 3]}, "items": [{"id": "p_1106", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1107", "content": "hyperlipidemia [SEP] lities. Puromycin aminonucleoside-induced renal dysfunction and hyperlipidemia were also suppressed. Histopathological examination revealed se", "tokenized_content": [2, 21381, 3, 4471, 2062, 18, 19750, 3835, 1022, 2626, 8028, 17, 2719, 4604, 5273, 1930, 21381, 1985, 2222, 7657, 18, 11777, 4981, 3404, 2058, 3]}, "items": [{"id": "p_1107", "content": "Hyperlipidemias [SEP] Conditions with excess LIPIDS in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21381, 1036, 3, 2961, 1956, 5799, 8238, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1108", "content": "renal damage [SEP]  also suppressed. Histopathological examination revealed severe renal damage such as proteinaceous casts in tubuli and tubular expansion in ", "tokenized_content": [2, 4604, 4293, 3, 2222, 7657, 18, 11777, 4981, 3404, 4010, 4604, 4293, 2427, 1966, 2213, 17101, 12273, 1036, 1922, 25860, 1033, 1930, 11755, 7013, 1922, 3]}, "items": [{"id": "p_1108", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1109", "content": "left ventricular apical ballooning syndrome [SEP] Reverse or inverted left ventricular apical ballooning syndrome (reverse Takotsubo cardiomyopathy) in a young woman in the sett", "tokenized_content": [2, 3506, 6493, 8913, 13819, 1941, 4741, 3, 5267, 2014, 12344, 3506, 6493, 8913, 13819, 1941, 4741, 12, 5267, 3393, 3882, 2255, 1037, 14141, 13, 1922, 43, 4201, 10440, 1922, 1920, 3]}, "items": [{"id": "p_1109", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_1110", "content": "Takotsubo cardiomyopathy [SEP] r inverted left ventricular apical ballooning syndrome (reverse Takotsubo cardiomyopathy) in a young woman in the setting of amphetamine use.", "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 60, 12344, 3506, 6493, 8913, 13819, 1941, 4741, 12, 5267, 3393, 3882, 2255, 1037, 14141, 13, 1922, 43, 4201, 10440, 1922, 1920, 4308, 1927, 3]}, "items": [{"id": "p_1110", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_1111", "content": "amphetamine [SEP] se Takotsubo cardiomyopathy) in a young woman in the setting of amphetamine use.", "tokenized_content": [2, 19057, 3, 2058, 3393, 3882, 2255, 1037, 14141, 13, 1922, 43, 4201, 10440, 1922, 1920, 4308, 1927, 19057, 2485, 18, 3]}, "items": [{"id": "p_1111", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1112", "content": "left ventricular apical ballooning syndrome [SEP] Transient left ventricular apical ballooning syndrome was first described in Japan as \"Takotsubo cardiomyopathy.\" Thi", "tokenized_content": [2, 3506, 6493, 8913, 13819, 1941, 4741, 3, 6809, 3506, 6493, 8913, 13819, 1941, 4741, 1982, 2561, 2910, 1922, 5834, 1966, 6, 3393, 3882, 2255, 1037, 14141, 18, 6, 7566, 3]}, "items": [{"id": "p_1112", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_1113", "content": "Takotsubo cardiomyopathy [SEP] lar apical ballooning syndrome was first described in Japan as \"Takotsubo cardiomyopathy.\" This syndrome has been identified in many other countries. Ma", "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 6590, 8913, 13819, 1941, 4741, 1982, 2561, 2910, 1922, 5834, 1966, 6, 3393, 3882, 2255, 1037, 14141, 18, 6, 2052, 4741, 2258, 2252, 2899, 3]}, "items": [{"id": "p_1113", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_1114", "content": "akinesia [SEP] erse type of this syndrome, with hyperdynamic apex and complete akinesia of the base (as opposed to the classic apical ballooning). In t", "tokenized_content": [2, 26162, 7156, 3, 22877, 1021, 2601, 1927, 2052, 4741, 16, 1956, 4194, 14458, 12253, 1935, 14091, 1930, 4080, 26162, 7156, 1927, 1920, 5170, 12, 1966, 12124, 1942, 1920, 12211, 8913, 3]}, "items": [{"id": "p_1114", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1115", "content": "apical ballooning [SEP] Transient left ventricular apical ballooning syndrome was first described in Japan as \"Takotsubo cardiomyopa", "tokenized_content": [2, 8913, 13819, 1941, 3, 6809, 3506, 6493, 8913, 13819, 1941, 4741, 1982, 2561, 2910, 1922, 5834, 1966, 6, 3393, 3882, 2255, 1037, 8291, 8228, 3]}, "items": [{"id": "p_1115", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_1116", "content": "apical ballooning syndrome [SEP] Transient left ventricular apical ballooning syndrome was first described in Japan as \"Takotsubo cardiomyopathy.\" Thi", "tokenized_content": [2, 8913, 13819, 1941, 4741, 3, 6809, 3506, 6493, 8913, 13819, 1941, 4741, 1982, 2561, 2910, 1922, 5834, 1966, 6, 3393, 3882, 2255, 1037, 14141, 18, 6, 7566, 3]}, "items": [{"id": "p_1116", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_1117", "content": "amphetamine [SEP] rare type of reverse apical ballooning syndrome occurring after amphetamine use. This report is followed by review of the literature.", "tokenized_content": [2, 19057, 3, 5844, 2601, 1927, 5267, 8913, 13819, 1941, 4741, 6966, 2256, 19057, 2485, 18, 2052, 3809, 1977, 3489, 2007, 3043, 1927, 1920, 4431, 18, 3]}, "items": [{"id": "p_1117", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1118", "content": "corticosterone [SEP] aminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats.", "tokenized_content": [2, 18136, 3, 13610, 1005, 11545, 4177, 2256, 5509, 10837, 1930, 8402, 18136, 2311, 1922, 3615, 18, 3]}, "items": [{"id": "p_1118", "content": "Corticosterone [SEP] An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman ", "score": 1, "type": null, "tokenized_content": [2, 18136, 3, 1925, 7206, 16557, 9507, 1988, 2258, 9194, 2308, 2228, 4209, 1966, 43, 8463, 10323, 2642, 1930, 43, 14469, 18, 12, 2037, 4227, 3862, 3]}]}
{"query": {"id": "q_1119", "content": "schizophrenia [SEP] The development of schizophrenia may include an early neurodevelopmental stress component which ", "tokenized_content": [2, 7899, 3, 1920, 2740, 1927, 7899, 2278, 3951, 1925, 3120, 19055, 3071, 4594, 2154, 3]}, "items": [{"id": "p_1119", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_1120", "content": "corticosterone [SEP] mbined with a later stress, simulated by chronic periadolescent corticosterone treatment, on behaviour in rats. Acute treatment with apomorphi", "tokenized_content": [2, 18136, 3, 5667, 2373, 1956, 43, 3690, 3071, 16, 7783, 2007, 3724, 2953, 28280, 1918, 3025, 18136, 2311, 16, 1990, 6270, 1922, 3615, 18, 3939, 2311, 1956, 11466, 12492, 11119, 3]}, "items": [{"id": "p_1120", "content": "Corticosterone [SEP] An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman ", "score": 1, "type": null, "tokenized_content": [2, 18136, 3, 1925, 7206, 16557, 9507, 1988, 2258, 9194, 2308, 2228, 4209, 1966, 43, 8463, 10323, 2642, 1930, 43, 14469, 18, 12, 2037, 4227, 3862, 3]}]}
{"query": {"id": "q_1121", "content": "apomorphine [SEP] costerone treatment, on behaviour in rats. Acute treatment with apomorphine caused disruption of prepulse inhibition (PPI) in controls and ", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 4455, 6506, 2912, 2311, 16, 1990, 6270, 1922, 3615, 18, 3939, 2311, 1956, 11466, 12492, 11119, 7969, 2912, 4189, 7561, 1927, 10719, 17765, 3523, 3]}, "items": [{"id": "p_1121", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_1122", "content": "Amphetamine [SEP]  in rats that had undergone the combined early and late stress. Amphetamine treatment significantly disrupted PPI in both non-deprived grou", "tokenized_content": [2, 19057, 3, 1922, 3615, 1988, 2430, 12299, 1920, 4252, 3120, 1930, 5058, 3071, 18, 19057, 2311, 2567, 11138, 12481, 1922, 2321, 2447, 17, 17080, 8947, 1032, 3]}, "items": [{"id": "p_1122", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1123", "content": "serotonin [SEP]  groups, but was absent in both maternally deprived groups. The serotonin-1A receptor agonist, 8-OH-DPAT, induced a significant disruptio", "tokenized_content": [2, 11153, 3, 2671, 16, 2308, 1982, 7685, 1922, 2321, 30206, 17080, 2671, 18, 1920, 11153, 17, 5123, 3148, 7829, 16, 28, 17, 5622, 17, 26202, 1031, 16, 2719, 43, 2228, 3]}, "items": [{"id": "p_1123", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1124", "content": "8-OH-DPAT [SEP]  maternally deprived groups. The serotonin-1A receptor agonist, 8-OH-DPAT, induced a significant disruption of PPI in all groups. Ampheta", "tokenized_content": [2, 28, 17, 5622, 17, 26202, 1031, 3, 30206, 17080, 2671, 18, 1920, 11153, 17, 5123, 3148, 7829, 16, 28, 17, 5622, 17, 26202, 1031, 16, 2719, 43, 2228, 7561, 1927, 3]}, "items": [{"id": "p_1124", "content": "8-Hydroxy-2-(di-n-propylamino)tetralin [SEP] A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28, 17, 8275, 17, 22, 17, 12, 2137, 17, 56, 17, 20299, 19143, 13, 12470, 7782, 3, 43, 11153, 5123, 17, 3148, 7829, 1988, 1977, 2251, 9568, 1942, 2648, 1920, 2564, 1927, 11153, 18, 3]}]}
{"query": {"id": "q_1125", "content": "locomotor hyperactivity [SEP] ignificant disruption of PPI in all groups. Amphetamine-induced locomotor hyperactivity was similar in all groups. These results show an inhibitory int", "tokenized_content": [2, 13594, 15534, 3, 12046, 2077, 2031, 7561, 1927, 12481, 1922, 2136, 2671, 18, 19057, 17, 2719, 13594, 15534, 1982, 2551, 1922, 2136, 2671, 18, 2144, 2274, 2146, 1925, 5431, 2218, 3]}, "items": [{"id": "p_1125", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1126", "content": "amphetamine [SEP] ergic regulation of PPI. The altered effects of apomorphine and amphetamine could indicate differential changes in dopamine receptor signal", "tokenized_content": [2, 19057, 3, 11949, 1935, 3640, 1927, 12481, 18, 1920, 5520, 2564, 1927, 11466, 12492, 11119, 7969, 2912, 1930, 19057, 2578, 3579, 5611, 2840, 1922, 7964, 3148, 2733, 3]}, "items": [{"id": "p_1126", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1127", "content": "dopamine [SEP]  'adolescent' stress, simulated by corticosterone treatment, on dopaminergic regulation of PPI. The altered effects of apomorphine and a", "tokenized_content": [2, 7964, 3, 11, 8402, 11, 3071, 16, 7783, 2007, 18136, 2311, 16, 1990, 12214, 3640, 1927, 12481, 18, 1920, 5520, 2564, 1927, 11466, 12492, 11119, 7969, 2912, 1930, 43, 3]}, "items": [{"id": "p_1127", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1128", "content": "iron dextran [SEP] Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia ", "tokenized_content": [2, 5680, 15195, 3, 5009, 5680, 15195, 2719, 9174, 1927, 12214, 3558, 1922, 3067, 21229, 3]}, "items": [{"id": "p_1128", "content": "Iron-Dextran Complex [SEP] A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is ", "score": 1, "type": null, "tokenized_content": [2, 5680, 17, 15195, 2796, 3, 43, 2796, 1927, 20247, 20004, 8535, 18068, 3695, 1956, 15195, 1036, 1927, 13576, 1942, 11851, 1008, 15880, 5405, 1036, 1922, 43, 24855, 3331, 3165, 2761, 2786, 19, 2646, 1927, 5680, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_1129", "content": "degeneration of dopaminergic neurons [SEP] Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra.", "tokenized_content": [2, 9174, 1927, 12214, 3558, 3, 5009, 5680, 15195, 2719, 9174, 1927, 12214, 3558, 1922, 3067, 21229, 20102, 18, 3]}, "items": [{"id": "p_1129", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_1130", "content": "Iron [SEP] Iron accumulation is considered to be involved in the pathogenesis o", "tokenized_content": [2, 5680, 3, 5680, 4858, 1977, 3311, 1942, 1998, 3286, 1922, 1920, 6559, 57, 3]}, "items": [{"id": "p_1130", "content": "Iron [SEP] A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBI", "score": 1, "type": null, "tokenized_content": [2, 5680, 3, 43, 16790, 6149, 1956, 11241, 17530, 2650, 16, 11241, 2529, 3179, 16, 1930, 11241, 3388, 4288, 18, 5140, 18, 2176, 1977, 1925, 4415, 18690, 1927, 3243, 6292, 1033, 3]}]}
{"query": {"id": "q_1131", "content": "Parkinson's disease [SEP] ccumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overlo", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 4928, 1989, 2281, 1977, 3311, 1942, 1998, 3286, 1922, 1920, 6559, 1927, 10124, 11, 61, 2573, 18, 1942, 4504, 1920, 3303, 2192, 5009, 5680, 20143, 3]}, "items": [{"id": "p_1131", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1132", "content": "iron [SEP] n's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (", "tokenized_content": [2, 5680, 3, 56, 11, 61, 2573, 18, 1942, 4504, 1920, 3303, 2192, 5009, 5680, 14491, 1930, 12214, 7428, 3257, 1922, 3067, 21229, 20102, 12, 3]}, "items": [{"id": "p_1132", "content": "Iron [SEP] A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBI", "score": 1, "type": null, "tokenized_content": [2, 5680, 3, 43, 16790, 6149, 1956, 11241, 17530, 2650, 16, 11241, 2529, 3179, 16, 1930, 11241, 3388, 4288, 18, 5140, 18, 2176, 1977, 1925, 4415, 18690, 1927, 3243, 6292, 1033, 3]}]}
{"query": {"id": "q_1133", "content": "tyrosine [SEP] gra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Perls' iron staining, an", "tokenized_content": [2, 6941, 3, 24689, 12, 3437, 13, 16, 1922, 1920, 2481, 2161, 2038, 2251, 5867, 9821, 23322, 5414, 16, 6941, 16324, 12, 1913, 13, 9101, 16, 24796, 1036, 11, 5680, 4166, 3]}, "items": [{"id": "p_1133", "content": "Tyrosine [SEP] A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HO", "score": 1, "type": null, "tokenized_content": [2, 6941, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 1922, 3555, 2176, 1977, 6653, 2037, 17388, 18, 2176, 1977, 2222, 1920, 7897, 1927, 19280, 31, 6918, 6673, 3]}]}
{"query": {"id": "q_1134", "content": "degeneration of dopaminergic neurons [SEP] ce liquid chromatography-electrochemical detection to study the degeneration of dopaminergic neurons and increased iron content in the SN of iron dextran overloaded", "tokenized_content": [2, 9174, 1927, 12214, 3558, 3, 5827, 5875, 7100, 17, 13197, 3805, 1942, 2161, 1920, 9174, 1927, 12214, 3558, 1930, 2502, 5680, 3919, 1922, 1920, 3437, 1927, 5680, 15195, 14491, 1919, 3]}, "items": [{"id": "p_1134", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_1135", "content": "iron dextran [SEP] of dopaminergic neurons and increased iron content in the SN of iron dextran overloaded animals. The findings showed that peripheral iron de", "tokenized_content": [2, 5680, 15195, 3, 1927, 12214, 3558, 1930, 2502, 5680, 3919, 1922, 1920, 3437, 1927, 5680, 15195, 14491, 1919, 3555, 18, 1920, 3056, 2594, 1988, 5009, 5680, 2028, 3]}, "items": [{"id": "p_1135", "content": "Iron-Dextran Complex [SEP] A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is ", "score": 1, "type": null, "tokenized_content": [2, 5680, 17, 15195, 2796, 3, 43, 2796, 1927, 20247, 20004, 8535, 18068, 3695, 1956, 15195, 1036, 1927, 13576, 1942, 11851, 1008, 15880, 5405, 1036, 1922, 43, 24855, 3331, 3165, 2761, 2786, 19, 2646, 1927, 5680, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_1136", "content": "dopamine [SEP] monstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present st", "tokenized_content": [2, 7964, 3, 28254, 18067, 1920, 3303, 2192, 5009, 5680, 14491, 1930, 12214, 7428, 3257, 1922, 3067, 21229, 20102, 12, 3437, 13, 16, 1922, 1920, 2481, 1955, 3]}, "items": [{"id": "p_1136", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1137", "content": "Warfarin [SEP] Warfarin-induced leukocytoclastic vasculitis.", "tokenized_content": [2, 16170, 3, 16170, 17, 2719, 5104, 3107, 5406, 4054, 21548, 18, 3]}, "items": [{"id": "p_1137", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_1138", "content": "leukocytoclastic vasculitis [SEP] Warfarin-induced leukocytoclastic vasculitis.", "tokenized_content": [2, 5104, 3107, 5406, 4054, 21548, 3, 16170, 17, 2719, 5104, 3107, 5406, 4054, 21548, 18, 3]}, "items": [{"id": "p_1138", "content": "Erythema elevatum diutinum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23349, 3946, 9576, 2137, 10574, 1989, 3, 3]}]}
{"query": {"id": "q_1139", "content": "coumarin [SEP] Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytocla", "tokenized_content": [2, 24503, 6454, 3, 4407, 5298, 2458, 1956, 4726, 24503, 6454, 17, 3595, 27691, 2032, 1925, 14403, 6564, 18, 5104, 3107, 5406, 1019, 3]}, "items": [{"id": "p_1139", "content": "coumarin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24503, 6454, 3, 3]}]}
{"query": {"id": "q_1140", "content": "Leukocytoclastic vasculitis [SEP] ral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though s", "tokenized_content": [2, 5104, 3107, 5406, 4054, 21548, 3, 15906, 24503, 6454, 17, 3595, 27691, 2032, 1925, 14403, 6564, 18, 5104, 3107, 5406, 4054, 21548, 12, 6701, 13, 1977, 5985, 43, 11276, 2858, 3]}, "items": [{"id": "p_1140", "content": "Erythema elevatum diutinum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23349, 3946, 9576, 2137, 10574, 1989, 3, 3]}]}
{"query": {"id": "q_1141", "content": "LV [SEP] ulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though syste", "tokenized_content": [2, 6701, 3, 3570, 2356, 2032, 1925, 14403, 6564, 18, 5104, 3107, 5406, 4054, 21548, 12, 6701, 13, 1977, 5985, 43, 11276, 2858, 8072, 21548, 16, 4170, 8055, 1021, 3]}, "items": [{"id": "p_1141", "content": "Erythema elevatum diutinum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23349, 3946, 9576, 2137, 10574, 1989, 3, 3]}]}
{"query": {"id": "q_1142", "content": "cutaneous small vessel vasculitis [SEP] mon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 pa", "tokenized_content": [2, 11276, 2858, 8072, 21548, 3, 2399, 6564, 18, 5104, 3107, 5406, 4054, 21548, 12, 6701, 13, 1977, 5985, 43, 11276, 2858, 8072, 21548, 16, 4170, 5510, 5668, 2278, 1998, 11989, 3]}, "items": [{"id": "p_1142", "content": "Vasculitis, Lymphocytic, Cutaneous Small Vessel [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 18921, 16, 11276, 2858, 8072, 3, 3]}]}
{"query": {"id": "q_1143", "content": "warfarin [SEP] ntered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed af", "tokenized_content": [2, 16170, 3, 5891, 7752, 18, 2038, 3809, 24, 2132, 1956, 5058, 17, 4727, 6701, 6226, 2810, 1942, 16170, 18, 2136, 24, 2132, 3549, 1956, 4407, 25655, 1036, 1988, 3530, 2221, 3]}, "items": [{"id": "p_1143", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_1144", "content": "skin eruptions [SEP] nset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The ", "tokenized_content": [2, 4407, 25655, 1036, 3, 28686, 1031, 6701, 6226, 2810, 1942, 16170, 18, 2136, 24, 2132, 3549, 1956, 4407, 25655, 1036, 1988, 3530, 2256, 5962, 16170, 1958, 2980, 2739, 18, 1920, 3]}, "items": [{"id": "p_1144", "content": "Skin Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4407, 3902, 3, 3]}]}
{"query": {"id": "q_1145", "content": "skin lesion [SEP] oped after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous ", "tokenized_content": [2, 4407, 5709, 3, 2494, 1919, 2256, 5962, 16170, 1958, 2980, 2739, 18, 1920, 2274, 1927, 4407, 5709, 9782, 1985, 3322, 1922, 23, 2132, 16, 10155, 6701, 11276, 3]}, "items": [{"id": "p_1145", "content": "Skin Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4407, 3902, 3, 3]}]}
{"query": {"id": "q_1146", "content": "LV Cutaneous lesions [SEP] f skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 ", "tokenized_content": [2, 6701, 11276, 4518, 3, 48, 4407, 5709, 9782, 1985, 3322, 1922, 23, 2132, 16, 10155, 6701, 11276, 4518, 8397, 1922, 2136, 2132, 2256, 16170, 1982, 16087, 18, 1922, 22, 3]}, "items": [{"id": "p_1146", "content": "Vasculitis, Leukocytoclastic, Cutaneous [SEP] Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or othe", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 5104, 3107, 5406, 4054, 16, 11276, 3, 4770, 4378, 2007, 43, 10205, 12013, 4741, 2458, 1956, 3395, 1942, 1925, 4730, 2427, 1966, 43, 2838, 16, 7465, 5899, 16, 2014, 7608, 4116, 3]}]}
{"query": {"id": "q_1147", "content": "N-methyl-D-aspartate [SEP] The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neuron", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 1920, 2936, 1927, 6071, 56, 17, 4963, 17, 46, 17, 12878, 4086, 2278, 4672, 1942, 9174, 1927, 6071, 4842, 7428, 3]}, "items": [{"id": "p_1147", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1148", "content": "morphine [SEP] te to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia.", "tokenized_content": [2, 11553, 3, 3602, 1942, 9174, 1927, 6071, 4842, 3558, 2719, 2007, 2974, 18049, 11553, 2256, 43, 12431, 13267, 19481, 1957, 4979, 1927, 6071, 6670, 7716, 18, 3]}, "items": [{"id": "p_1148", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_1149", "content": "spinal cord ischemia [SEP]  induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia.", "tokenized_content": [2, 6071, 6670, 7716, 3, 2719, 2007, 2974, 18049, 11553, 2256, 43, 12431, 13267, 19481, 1957, 4979, 1927, 6071, 6670, 7716, 18, 3]}, "items": [{"id": "p_1149", "content": "Spinal Cord Ischemia [SEP] Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. ", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 7716, 3, 3028, 2877, 3426, 1942, 1920, 6071, 6670, 2154, 1977, 13164, 2007, 1920, 5477, 6071, 5511, 1930, 1920, 7304, 5545, 6071, 9345, 18, 3]}]}
{"query": {"id": "q_1150", "content": "N-methyl-d-aspartate [SEP] ween the degeneration of spinal motor neurons and activation of N-methyl-d-aspartate (NMDA) receptors after neuraxial morphine following a noninjuri", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 2038, 1917, 1920, 9174, 1927, 6071, 4842, 3558, 1930, 2936, 1927, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 4086, 3]}, "items": [{"id": "p_1150", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1151", "content": "NMDA [SEP] of spinal motor neurons and activation of N-methyl-d-aspartate (NMDA) receptors after neuraxial morphine following a noninjurious in", "tokenized_content": [2, 10976, 3, 1927, 6071, 4842, 3558, 1930, 2936, 1927, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 4086, 2256, 2974, 18049, 11553, 2894, 43, 12431, 13267, 19481, 1957, 3]}, "items": [{"id": "p_1151", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1152", "content": "morphine [SEP] vation of N-methyl-d-aspartate (NMDA) receptors after neuraxial morphine following a noninjurious interval of aortic occlusion in rats. ", "tokenized_content": [2, 11553, 3, 23272, 2001, 1927, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 4086, 2256, 2974, 18049, 11553, 2894, 43, 12431, 13267, 19481, 1957, 4979, 1927, 7677, 10543, 3]}, "items": [{"id": "p_1152", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_1153", "content": "aortic occlusion [SEP] s after neuraxial morphine following a noninjurious interval of aortic occlusion in rats. Spinal cord ischemia was induced by aortic occlusion f", "tokenized_content": [2, 7677, 10543, 3, 61, 2256, 2974, 18049, 11553, 2894, 43, 12431, 13267, 19481, 1957, 4979, 1927, 7677, 10543, 1922, 3615, 18, 6071, 6670, 7716, 1982, 2719, 2007, 7677, 10543, 48, 3]}, "items": [{"id": "p_1153", "content": "Arterial Occlusive Diseases [SEP] Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduce", "score": 1, "type": null, "tokenized_content": [2, 6624, 28715, 3902, 3, 6598, 4028, 2154, 3211, 1922, 1920, 5740, 2014, 4080, 10849, 1927, 9345, 18, 2611, 2032, 4378, 2007, 8138, 4412, 3]}]}
{"query": {"id": "q_1154", "content": "Spinal cord ischemia [SEP]  following a noninjurious interval of aortic occlusion in rats. Spinal cord ischemia was induced by aortic occlusion for 6 min with a balloon cathet", "tokenized_content": [2, 6071, 6670, 7716, 3, 2894, 43, 12431, 13267, 19481, 1957, 4979, 1927, 7677, 10543, 1922, 3615, 18, 6071, 6670, 7716, 1982, 2719, 2007, 7677, 10543, 1958, 26, 2360, 1956, 43, 3]}, "items": [{"id": "p_1154", "content": "Spinal Cord Ischemia [SEP] Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. ", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 7716, 3, 3028, 2877, 3426, 1942, 1920, 6071, 6670, 2154, 1977, 13164, 2007, 1920, 5477, 6071, 5511, 1930, 1920, 7304, 5545, 6071, 9345, 18, 3]}]}
{"query": {"id": "q_1155", "content": "MK-801 [SEP]  (after IT injection). Second, we investigated the effect of IT MK-801 (30 mug) on the histopathologic changes in the spinal cord afte", "tokenized_content": [2, 10539, 17, 23858, 3, 12, 2256, 2176, 4107, 13, 18, 2812, 16, 2038, 3845, 1920, 2495, 1927, 2176, 10539, 17, 23858, 12, 2627, 28991, 13, 1990, 1920, 20324, 2840, 1922, 3]}, "items": [{"id": "p_1155", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_1156", "content": "spastic paraparesis [SEP] stopathologic changes in the spinal cord after morphine-induced spastic paraparesis. After IT morphine, the cerebrospinal fluid (CSF) glutamate con", "tokenized_content": [2, 21817, 22224, 9392, 1937, 3, 6875, 2183, 4467, 2840, 1922, 1920, 6071, 6670, 2256, 11553, 17, 2719, 21817, 22224, 9392, 1937, 18, 2256, 2176, 11553, 16, 1920, 15448, 5466, 12, 3]}, "items": [{"id": "p_1156", "content": "Paraparesis, Spastic [SEP] Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of", "score": 1, "type": null, "tokenized_content": [2, 22224, 9392, 1937, 16, 21817, 3, 5809, 2014, 5086, 3257, 1927, 4842, 2347, 7936, 2007, 29232, 1922, 1920, 2826, 18884, 18, 2052, 2625, 1977, 43, 15570, 1927, 3]}]}
{"query": {"id": "q_1157", "content": "glutamate [SEP] c paraparesis. After IT morphine, the cerebrospinal fluid (CSF) glutamate concentration was increased in group M relative to both baselin", "tokenized_content": [2, 7627, 3, 45, 22224, 9392, 1937, 18, 2256, 2176, 11553, 16, 1920, 15448, 5466, 12, 6399, 13, 7627, 3110, 1982, 2502, 1922, 2210, 55, 3338, 1942, 2321, 25672, 1921, 3]}, "items": [{"id": "p_1157", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_1158", "content": "neurotoxic [SEP] ved in NMDA receptor activation. We suggest that opioids may be neurotoxic in the setting of spinal cord ischemia via NMDA receptor activa", "tokenized_content": [2, 20919, 3, 3428, 1007, 1922, 10976, 3148, 2936, 18, 2038, 3220, 1988, 16218, 2278, 1998, 20919, 1922, 1920, 4308, 1927, 6071, 6670, 7716, 3454, 10976, 3148, 2196, 1019, 3]}, "items": [{"id": "p_1158", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_1159", "content": "spinal cord ischemia [SEP] on. We suggest that opioids may be neurotoxic in the setting of spinal cord ischemia via NMDA receptor activation.", "tokenized_content": [2, 6071, 6670, 7716, 3, 1990, 18, 2038, 3220, 1988, 16218, 2278, 1998, 20919, 1922, 1920, 4308, 1927, 6071, 6670, 7716, 3454, 10976, 3148, 2936, 18, 3]}, "items": [{"id": "p_1159", "content": "Spinal Cord Ischemia [SEP] Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. ", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 7716, 3, 3028, 2877, 3426, 1942, 1920, 6071, 6670, 2154, 1977, 13164, 2007, 1920, 5477, 6071, 5511, 1930, 1920, 7304, 5545, 6071, 9345, 18, 3]}]}
{"query": {"id": "q_1160", "content": "sodium [SEP] Reduced sodium channel density, altered voltage dependence of inactivation, an", "tokenized_content": [2, 5227, 3, 3028, 5227, 4999, 3824, 16, 5520, 6889, 6816, 1927, 8005, 16, 1925, 3]}, "items": [{"id": "p_1160", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1161", "content": "seizures [SEP] age dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.", "tokenized_content": [2, 10060, 3, 2632, 6816, 1927, 8005, 16, 1930, 2502, 6461, 1942, 10060, 1922, 2518, 7046, 5227, 4999, 4666, 22, 17, 6991, 18, 3]}, "items": [{"id": "p_1161", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1162", "content": "Sodium [SEP] Sodium channel beta-subunits modulate channel gating, assembly, and ce", "tokenized_content": [2, 5227, 3, 5227, 4999, 4666, 17, 6991, 8480, 4999, 12568, 16, 5957, 16, 1930, 5827, 3]}, "items": [{"id": "p_1162", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1163", "content": "sodium [SEP]  beta2(-/-) mice to investigate the role of beta2 in control of sodium channel density, localization, and function in neurons in vivo.", "tokenized_content": [2, 5227, 3, 4666, 1028, 12, 17, 19, 17, 13, 2518, 1942, 4482, 1920, 2770, 1927, 4666, 1028, 1922, 2285, 1927, 5227, 4999, 3824, 16, 5363, 16, 1930, 2347, 1922, 3558, 3]}, "items": [{"id": "p_1163", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1164", "content": "saxitoxin [SEP] ization, and function in neurons in vivo. Measurements of [(3)H]saxitoxin (STX) binding showed a significant reduction in the level of pl", "tokenized_content": [2, 18585, 8752, 10960, 3, 25455, 1943, 16, 1930, 2347, 1922, 3558, 1922, 3597, 18, 4146, 1927, 37, 12, 23, 13, 50, 39, 18585, 8752, 10960, 12, 24489, 13, 2743, 2594, 3]}, "items": [{"id": "p_1164", "content": "Saxitoxin [SEP] A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poiso", "score": 1, "type": null, "tokenized_content": [2, 18585, 8752, 10960, 3, 43, 3547, 1988, 5461, 43, 3028, 19700, 6335, 2433, 2308, 1977, 2084, 14041, 2169, 2712, 1942, 1920, 19700, 22390, 18, 2176, 1977, 43, 2510, 23854, 3]}]}
{"query": {"id": "q_1165", "content": "STX [SEP] d function in neurons in vivo. Measurements of [(3)H]saxitoxin (STX) binding showed a significant reduction in the level of plasma ", "tokenized_content": [2, 24489, 3, 46, 2347, 1922, 3558, 1922, 3597, 18, 4146, 1927, 37, 12, 23, 13, 50, 39, 18585, 8752, 10960, 12, 24489, 13, 2743, 2594, 43, 2228, 3378, 1922, 1920, 3]}, "items": [{"id": "p_1165", "content": "Saxitoxin [SEP] A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poiso", "score": 1, "type": null, "tokenized_content": [2, 18585, 8752, 10960, 3, 43, 3547, 1988, 5461, 43, 3028, 19700, 6335, 2433, 2308, 1977, 2084, 14041, 2169, 2712, 1942, 1920, 19700, 22390, 18, 2176, 1977, 43, 2510, 23854, 3]}]}
{"query": {"id": "q_1166", "content": "Na [SEP] e of axons in the optic nerve, and the specific localization of Na(v)1.6 channels in the nodes of Ranvier were unchanged. beta2(-/", "tokenized_content": [2, 4049, 3, 47, 1927, 9725, 1922, 1920, 10109, 5507, 16, 1930, 1920, 2487, 5363, 1927, 4049, 12, 64, 13, 21, 18, 26, 5628, 1922, 1920, 6263, 1927, 2845, 23862, 1985, 3]}, "items": [{"id": "p_1166", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1167", "content": "seizures [SEP] nchanged. beta2(-/-) mice displayed increased susceptibility to seizures, as indicated by reduced latency and threshold for pilocarpine-", "tokenized_content": [2, 10060, 3, 5301, 15409, 4428, 18, 4666, 1028, 12, 17, 19, 17, 13, 2518, 5822, 2502, 6461, 1942, 10060, 16, 1966, 3391, 2007, 3028, 9393, 1930, 4683, 1958, 7547, 7095, 3]}, "items": [{"id": "p_1167", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1168", "content": "pilocarpine [SEP]  to seizures, as indicated by reduced latency and threshold for pilocarpine-induced seizures, but seemed normal in other neurological tests", "tokenized_content": [2, 7547, 7095, 12184, 3, 1942, 10060, 16, 1966, 3391, 2007, 3028, 9393, 1930, 4683, 1958, 7547, 7095, 12184, 17, 2719, 10060, 16, 2308, 12292, 2791, 1922, 2303, 7605, 4026, 3]}, "items": [{"id": "p_1168", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_1169", "content": "seizure [SEP] Screening for stimulant use in adult emergency department seizure patients.", "tokenized_content": [2, 11015, 3, 4449, 1958, 24252, 2485, 1922, 4160, 7877, 6143, 11015, 2132, 18, 3]}, "items": [{"id": "p_1169", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1170", "content": "cocaine [SEP]  determine the prevalence of positive plasma drug screening for cocaine or amphetamine in adult emergency department seizure patients. ", "tokenized_content": [2, 9045, 3, 3415, 1920, 4077, 1927, 2843, 3582, 2838, 4449, 1958, 9045, 2014, 19057, 1922, 4160, 7877, 6143, 11015, 2132, 18, 3]}, "items": [{"id": "p_1170", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1171", "content": "amphetamine [SEP] the prevalence of positive plasma drug screening for cocaine or amphetamine in adult emergency department seizure patients. METHODS: This p", "tokenized_content": [2, 19057, 3, 1920, 4077, 1927, 2843, 3582, 2838, 4449, 1958, 9045, 2014, 19057, 1922, 4160, 7877, 6143, 11015, 2132, 18, 2860, 30, 2052, 58, 3]}, "items": [{"id": "p_1171", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1172", "content": "seizure [SEP] eening for cocaine or amphetamine in adult emergency department seizure patients. METHODS: This prospective study evaluated consecutive", "tokenized_content": [2, 11015, 3, 11150, 2989, 1958, 9045, 2014, 19057, 1922, 4160, 7877, 6143, 11015, 2132, 18, 2860, 30, 2052, 6315, 2161, 3747, 7351, 3]}, "items": [{"id": "p_1172", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1173", "content": "benzoylecgonine [SEP] n. Plasma was tested for amphetamine and the cocaine metabolite benzoylecgonine using enzyme-mediated immunoassay methodology. Plasma samples w", "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 56, 18, 3582, 1982, 3620, 1958, 19057, 1930, 1920, 9045, 9483, 19225, 6752, 1030, 3827, 8635, 2912, 2193, 4113, 17, 3434, 17705, 8087, 3]}, "items": [{"id": "p_1173", "content": "benzoylecgonine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 3]}]}
{"query": {"id": "q_1174", "content": "alcohol [SEP] s positive. Patient demographics, history of underlying drug or alcohol-related seizure disorder, estimated time from seizure to sample", "tokenized_content": [2, 4284, 3, 61, 2843, 18, 2774, 12593, 16, 4403, 1927, 5030, 2838, 2014, 4284, 17, 2712, 11015, 4770, 16, 4185, 2367, 2037, 11015, 1942, 2983, 3]}, "items": [{"id": "p_1174", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_1175", "content": "amphetamine abuse [SEP] eizure to sample collection, history or suspicion of cocaine or amphetamine abuse, results of clinical urine testing for drugs of abuse, and assa", "tokenized_content": [2, 19057, 7764, 3, 16101, 19240, 1936, 1942, 2983, 4957, 16, 4403, 2014, 18419, 1927, 9045, 2014, 19057, 7764, 16, 2274, 1927, 2535, 6960, 4213, 1958, 4195, 1927, 7764, 16, 1930, 3]}, "items": [{"id": "p_1175", "content": "Amphetamine-Related Disorders [SEP] Disorders related or resulting from use of amphetamines.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19057, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 19057, 1036, 18, 3]}]}
{"query": {"id": "q_1176", "content": "amphetamines [SEP] ing this study period, routine plasma screening for cocaine and amphetamines in adult seizure patients had a low yield. As a result, routine", "tokenized_content": [2, 19057, 1036, 3, 30393, 2052, 2161, 3047, 16, 7341, 3582, 4449, 1958, 9045, 1930, 19057, 1036, 1922, 4160, 11015, 2132, 2430, 43, 2330, 4307, 18, 1966, 43, 3211, 16, 7341, 3]}, "items": [{"id": "p_1176", "content": "Amphetamines [SEP] Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vaso", "score": 1, "type": null, "tokenized_content": [2, 19057, 1036, 3, 13204, 2014, 8383, 1927, 19057, 18, 3086, 2032, 26638, 1947, 21870, 1036, 1930, 4101, 7580, 2433, 24052, 1036, 7538, 8392, 16, 22866, 3]}]}
{"query": {"id": "q_1177", "content": "drug abuse [SEP] lant drug in which there was neither a history nor suspicion of drug abuse in this population.", "tokenized_content": [2, 2838, 7764, 3, 19027, 1031, 2838, 1922, 2154, 2276, 1982, 7132, 43, 4403, 3990, 18419, 1927, 2838, 7764, 1922, 2052, 2973, 18, 3]}, "items": [{"id": "p_1177", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_1178", "content": "parkinsonian [SEP] rnus (GPi) by studying the effects of unilateral pallidotomy on parkinsonian 'off' signs and levodopa-induced dyskinesias (LID). We found si", "tokenized_content": [2, 10124, 3122, 3, 6364, 1957, 12, 17497, 13, 2007, 9689, 1920, 2564, 1927, 12059, 12574, 22389, 4575, 14930, 1990, 10124, 3122, 11, 4013, 11, 6879, 1930, 26723, 17, 2719, 3890, 3]}, "items": [{"id": "p_1178", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1179", "content": "levodopa [SEP] fects of unilateral pallidotomy on parkinsonian 'off' signs and levodopa-induced dyskinesias (LID). We found significant positive correl", "tokenized_content": [2, 26723, 3, 16688, 1973, 1927, 12059, 12574, 22389, 4575, 14930, 1990, 10124, 3122, 11, 4013, 11, 6879, 1930, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 2435, 3]}, "items": [{"id": "p_1179", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_1180", "content": "dyskinesias [SEP] al pallidotomy on parkinsonian 'off' signs and levodopa-induced dyskinesias (LID). We found significant positive correlations between the p", "tokenized_content": [2, 3890, 26682, 1036, 3, 1969, 12574, 22389, 4575, 14930, 1990, 10124, 3122, 11, 4013, 11, 6879, 1930, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 2435, 2228, 3]}, "items": [{"id": "p_1180", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1181", "content": "LID [SEP] y on parkinsonian 'off' signs and levodopa-induced dyskinesias (LID). We found significant positive correlations between the preope", "tokenized_content": [2, 13096, 3, 67, 1990, 10124, 3122, 11, 4013, 11, 6879, 1930, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 2435, 2228, 2843, 6100, 2192, 1920, 2097, 4907, 3]}, "items": [{"id": "p_1181", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1182", "content": "parkinsonism [SEP] . Whereas cells in a wider area of the GPi may be implicated in parkinsonism, the ventral GPi seems to be crucial for the manifestation of L", "tokenized_content": [2, 26214, 3, 18, 3417, 2094, 1922, 43, 12172, 3403, 1927, 1920, 17497, 2278, 1998, 6835, 1922, 26214, 16, 1920, 8420, 17497, 6123, 1942, 1998, 6608, 1958, 1920, 15570, 1927, 54, 3]}, "items": [{"id": "p_1182", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1183", "content": "Pain [SEP] Pain responses in methadone-maintained opioid abusers.", "tokenized_content": [2, 3594, 3, 3594, 3387, 1922, 20293, 17, 5514, 9384, 7764, 5675, 18, 3]}, "items": [{"id": "p_1183", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_1184", "content": "methadone [SEP] Pain responses in methadone-maintained opioid abusers.", "tokenized_content": [2, 20293, 3, 3594, 3387, 1922, 20293, 17, 5514, 9384, 7764, 5675, 18, 3]}, "items": [{"id": "p_1184", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_1185", "content": "pain [SEP] Providing pain management for known opioid abusers is a challenging clinical t", "tokenized_content": [2, 3594, 3, 5453, 3594, 4280, 1958, 3171, 9384, 7764, 5675, 1977, 43, 8764, 2535, 62, 3]}, "items": [{"id": "p_1185", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_1186", "content": "opioid addicts [SEP] o describe pain tolerance and analgesic response in a sample of opioid addicts stabilized in methadone-maintenance (MM) treatment (n = 60) in ", "tokenized_content": [2, 9384, 16888, 1973, 3, 57, 5993, 3594, 6555, 1930, 14501, 2644, 1922, 43, 2983, 1927, 9384, 16888, 1973, 12017, 1922, 20293, 17, 6291, 12, 2489, 13, 2311, 12, 56, 33, 3]}, "items": [{"id": "p_1186", "content": "Opioid-Related Disorders [SEP] Disorders related or resulting from abuse or mis-use of opioids.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9384, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 7764, 2014, 5682, 17, 2485, 1927, 16218, 18, 3]}]}
{"query": {"id": "q_1187", "content": "methadone [SEP]  analgesic response in a sample of opioid addicts stabilized in methadone-maintenance (MM) treatment (n = 60) in comparison to matched no", "tokenized_content": [2, 20293, 3, 14501, 2644, 1922, 43, 2983, 1927, 9384, 16888, 1973, 12017, 1922, 20293, 17, 6291, 12, 2489, 13, 2311, 12, 56, 33, 3276, 13, 1922, 3723, 1942, 5992, 2239, 3]}, "items": [{"id": "p_1187", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_1188", "content": "hydromorphone [SEP] fter oral administration of therapeutic doses of common opioid (hydromorphone 2 mg) and nonsteroidal anti-inflammatory (ketorolac 10 mg) anal", "tokenized_content": [2, 3290, 12492, 11119, 10647, 2912, 3, 8916, 1915, 4726, 4183, 1927, 4272, 5312, 1927, 3059, 9384, 12, 3290, 12492, 11119, 10647, 2912, 22, 2786, 13, 1930, 29413, 2246, 17, 3769, 3]}, "items": [{"id": "p_1188", "content": "Hydromorphone [SEP] An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3290, 12492, 11119, 10647, 2912, 3, 1925, 9384, 14501, 3915, 2037, 11553, 1930, 2251, 4994, 1966, 1925, 14501, 18, 2176, 2258, 43, 7310, 4392, 1927, 4615, 2254, 11553, 18, 3]}]}
{"query": {"id": "q_1189", "content": "ketorolac [SEP] opioid (hydromorphone 2 mg) and nonsteroidal anti-inflammatory (ketorolac 10 mg) analgesic agents. Results showed that MM individuals wer", "tokenized_content": [2, 21471, 2226, 1948, 3, 9384, 12, 3290, 12492, 11119, 10647, 2912, 22, 2786, 13, 1930, 29413, 2246, 17, 3769, 12, 21471, 2226, 1948, 2119, 2786, 13, 14501, 4820, 18, 2274, 3]}, "items": [{"id": "p_1189", "content": "Ketorolac [SEP] A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its an", "score": 1, "type": null, "tokenized_content": [2, 21471, 2226, 1948, 3, 43, 23878, 2061, 2053, 18708, 2687, 10533, 12171, 2712, 1942, 20463, 18, 2176, 1977, 1925, 24194, 1930, 1977, 2251, 22581, 1958, 2496, 1925, 3]}]}
{"query": {"id": "q_1190", "content": "pain-intolerant [SEP] r group. These data indicate that MM opioid abusers represent a pain-intolerant subset of clinical patients. Their complaints of pain should be", "tokenized_content": [2, 3594, 17, 16193, 2031, 3, 60, 2210, 18, 2144, 2230, 3579, 1988, 2489, 9384, 7764, 5675, 3015, 43, 3594, 17, 16193, 2031, 6728, 1927, 2535, 2132, 18, 2310, 14782, 1927, 3]}, "items": [{"id": "p_1190", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_1191", "content": "renal tubular dysfunction [SEP] BACKGROUND: Although an indicator of renal tubular dysfunction, an increased urinary N-acetyl-beta-D-glucosaminidase (NAG) act", "tokenized_content": [2, 4604, 11755, 5273, 3, 3872, 30, 2876, 1925, 8413, 1927, 4604, 11755, 5273, 16, 1925, 2502, 7075, 56, 17, 6894, 17, 4666, 17, 46, 17, 3351, 5360, 8547, 9200, 12, 3]}, "items": [{"id": "p_1191", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_1192", "content": "Puromycin aminonucleoside [SEP] t increased lysosomal activity in renal tubular cells. METHODS: Puromycin aminonucleoside (PAN) was administered to Sprague Dawley rats to induce protein", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 62, 2502, 12097, 2455, 1922, 4604, 11755, 2094, 18, 2860, 30, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 1982, 5254, 1942, 15684, 15798, 3]}, "items": [{"id": "p_1192", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_1193", "content": "PAN [SEP] ity in renal tubular cells. METHODS: Puromycin aminonucleoside (PAN) was administered to Sprague Dawley rats to induce proteinuria.", "tokenized_content": [2, 3797, 3, 2176, 1012, 1922, 4604, 11755, 2094, 18, 2860, 30, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 1982, 5254, 1942, 15684, 15798, 3615, 1942, 4769, 15831, 18, 3]}, "items": [{"id": "p_1193", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_1194", "content": "proteinuria [SEP] leoside (PAN) was administered to Sprague Dawley rats to induce proteinuria. Total protein, albumin, NAG activity and protein electrophoret", "tokenized_content": [2, 15831, 3, 2071, 8028, 12, 3797, 13, 1982, 5254, 1942, 15684, 15798, 3615, 1942, 4769, 15831, 18, 2698, 2213, 16, 7712, 16, 14466, 2455, 1930, 2213, 17174, 1031, 3]}, "items": [{"id": "p_1194", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1195", "content": "estrogen [SEP] helial growth factor and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tum", "tokenized_content": [2, 7940, 3, 3091, 2086, 2905, 2991, 1930, 2496, 3148, 2409, 1920, 2740, 1927, 7940, 17, 2719, 3067, 10621, 3861, 2278, 8265, 7940, 17, 7796, 2497, 3]}, "items": [{"id": "p_1195", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1196", "content": "pituitary tumors [SEP] and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesis.", "tokenized_content": [2, 10621, 3861, 3, 1930, 2496, 3148, 2409, 1920, 2740, 1927, 7940, 17, 2719, 3067, 10621, 3861, 2278, 8265, 7940, 17, 7796, 2798, 8244, 18, 3]}, "items": [{"id": "p_1196", "content": "Pituitary Neoplasms [SEP] Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are di", "score": 1, "type": null, "tokenized_content": [2, 10621, 15347, 3, 15347, 2154, 10149, 2037, 2014, 23257, 2606, 1942, 1920, 10621, 8359, 18, 1920, 4827, 1927, 10621, 15347, 2032, 16787, 16, 2154, 2032, 2137, 3]}]}
{"query": {"id": "q_1197", "content": "tumor [SEP] ceptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesis.", "tokenized_content": [2, 2798, 3, 17008, 2684, 2409, 1920, 2740, 1927, 7940, 17, 2719, 3067, 10621, 3861, 2278, 8265, 7940, 17, 7796, 2798, 8244, 18, 3]}, "items": [{"id": "p_1197", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1198", "content": "Estrogens [SEP] Estrogens, which have been associated with several types of human and ani", "tokenized_content": [2, 20470, 3, 20470, 16, 2154, 2162, 2252, 2458, 1956, 2980, 3584, 1927, 2616, 1930, 1925, 1033, 3]}, "items": [{"id": "p_1198", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1199", "content": "cancers [SEP] ich have been associated with several types of human and animal cancers, can induce tumor angiogenesis in the pituitary of Fischer 344 ", "tokenized_content": [2, 5717, 3, 14910, 2162, 2252, 2458, 1956, 2980, 3584, 1927, 2616, 1930, 4027, 5717, 16, 2112, 4769, 2798, 8244, 1922, 1920, 10621, 1927, 20113, 23473, 3]}, "items": [{"id": "p_1199", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1200", "content": "tumor [SEP] ated with several types of human and animal cancers, can induce tumor angiogenesis in the pituitary of Fischer 344 rats. The mechanis", "tokenized_content": [2, 2798, 3, 30280, 1007, 1956, 2980, 3584, 1927, 2616, 1930, 4027, 5717, 16, 2112, 4769, 2798, 8244, 1922, 1920, 10621, 1927, 20113, 23473, 3615, 18, 1920, 2665, 1937, 3]}, "items": [{"id": "p_1200", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1201", "content": "estrogen [SEP] The mechanistic details of tumor angiogenesis induction, during estrogen carcinogenesis, are still unknown. To elucidate the role of est", "tokenized_content": [2, 7940, 3, 1920, 10640, 6331, 1927, 2798, 8244, 4408, 16, 2409, 7940, 12559, 16, 2032, 3974, 5435, 18, 1942, 9970, 1920, 2770, 1927, 3255, 3]}, "items": [{"id": "p_1201", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1202", "content": "carcinogenesis [SEP] nistic details of tumor angiogenesis induction, during estrogen carcinogenesis, are still unknown. To elucidate the role of estrogen in the re", "tokenized_content": [2, 12559, 3, 17299, 2002, 6331, 1927, 2798, 8244, 4408, 16, 2409, 7940, 12559, 16, 2032, 3974, 5435, 18, 1942, 9970, 1920, 2770, 1927, 7940, 1922, 1920, 1964, 3]}, "items": [{"id": "p_1202", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_1203", "content": "17beta-estradiol [SEP] examined by immunohistochemistry. The results demonstrated that 17beta-estradiol (E2) induces neovascularization, as well as the growth and enla", "tokenized_content": [2, 2752, 20440, 17, 11513, 3, 3572, 2007, 9101, 18, 1920, 2274, 3161, 1988, 2752, 20440, 17, 11513, 12, 6602, 13, 6387, 20060, 16, 1966, 2486, 1966, 1920, 2905, 1930, 9593, 3]}, "items": [{"id": "p_1203", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_1204", "content": "E2 [SEP] histochemistry. The results demonstrated that 17beta-estradiol (E2) induces neovascularization, as well as the growth and enlargem", "tokenized_content": [2, 6602, 3, 2968, 7202, 18, 1920, 2274, 3161, 1988, 2752, 20440, 17, 11513, 12, 6602, 13, 6387, 20060, 16, 1966, 2486, 1966, 1920, 2905, 1930, 15258, 1987, 3]}, "items": [{"id": "p_1204", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_1205", "content": "Pravastatin [SEP] Pravastatin-associated myopathy. Report of a case.", "tokenized_content": [2, 21227, 15337, 3, 21227, 15337, 17, 2458, 25017, 18, 3809, 1927, 43, 3087, 18, 3]}, "items": [{"id": "p_1205", "content": "Pravastatin [SEP] An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA ", "score": 1, "type": null, "tokenized_content": [2, 21227, 15337, 3, 1925, 2246, 8257, 4197, 8697, 9483, 3937, 2037, 5054, 1927, 9812, 13047, 5728, 1997, 2688, 6102, 18, 2176, 8016, 1966, 43, 10362, 4106, 1927, 12058, 10027, 3]}]}
{"query": {"id": "q_1206", "content": "myopathy [SEP] Pravastatin-associated myopathy. Report of a case.", "tokenized_content": [2, 25017, 3, 21227, 15337, 17, 2458, 25017, 18, 3809, 1927, 43, 3087, 18, 3]}, "items": [{"id": "p_1206", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1207", "content": "inflammatory myopathy [SEP] A case of acute inflammatory myopathy associated with the use of pravastatin, a new hydrophilic 3-hyd", "tokenized_content": [2, 3769, 25017, 3, 43, 3087, 1927, 3939, 3769, 25017, 2458, 1956, 1920, 2485, 1927, 21227, 15337, 16, 43, 2814, 14033, 23, 17, 2993, 3]}, "items": [{"id": "p_1207", "content": "Myositis [SEP] Inflammation of a muscle or muscle tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15924, 12924, 3600, 3, 4531, 1927, 43, 3760, 2014, 3760, 2960, 18, 3]}]}
{"query": {"id": "q_1208", "content": "pravastatin [SEP]  case of acute inflammatory myopathy associated with the use of pravastatin, a new hydrophilic 3-hydroxy-3 methylglutaril coenzyme A reduct", "tokenized_content": [2, 21227, 15337, 3, 3087, 1927, 3939, 3769, 25017, 2458, 1956, 1920, 2485, 1927, 21227, 15337, 16, 43, 2814, 14033, 23, 17, 8275, 17, 23, 4963, 16542, 2205, 1024, 22051, 43, 3]}, "items": [{"id": "p_1208", "content": "Pravastatin [SEP] An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA ", "score": 1, "type": null, "tokenized_content": [2, 21227, 15337, 3, 1925, 2246, 8257, 4197, 8697, 9483, 3937, 2037, 5054, 1927, 9812, 13047, 5728, 1997, 2688, 6102, 18, 2176, 8016, 1966, 43, 10362, 4106, 1927, 12058, 10027, 3]}]}
{"query": {"id": "q_1209", "content": "non-insulin-dependent diabetes mellitus [SEP] or, is reported. The patient, a 69-year-old man was affected by non-insulin-dependent diabetes mellitus and hypertension. He assumed pravastatin (20 mg/day) because of", "tokenized_content": [2, 2447, 17, 4122, 17, 3100, 4032, 9695, 3, 2014, 16, 1977, 2568, 18, 1920, 2774, 16, 43, 5349, 17, 2476, 17, 4156, 2323, 1982, 4218, 2007, 2447, 17, 4122, 17, 3]}, "items": [{"id": "p_1209", "content": "Diabetes Mellitus, Type 2 [SEP] A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RE", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 16, 2601, 22, 3, 43, 17625, 1927, 4032, 9695, 1988, 1977, 2084, 4122, 17, 8487, 2014, 3100, 12, 17991, 6366, 13, 18, 2176, 1977, 4378, 6370, 2007, 4122, 1964, 3]}]}
{"query": {"id": "q_1210", "content": "hypertension [SEP] man was affected by non-insulin-dependent diabetes mellitus and hypertension. He assumed pravastatin (20 mg/day) because of hypercholesterol", "tokenized_content": [2, 5579, 3, 2323, 1982, 4218, 2007, 2447, 17, 4122, 17, 3100, 4032, 9695, 1930, 5579, 18, 2234, 7696, 21227, 15337, 12, 2036, 2786, 19, 3007, 13, 2882, 1927, 19284, 3]}, "items": [{"id": "p_1210", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1211", "content": "hypercholesterolemia [SEP] and hypertension. He assumed pravastatin (20 mg/day) because of hypercholesterolemia. He was admitted with acute myopathy of the lower limbs which r", "tokenized_content": [2, 22862, 3, 1930, 5579, 18, 2234, 7696, 21227, 15337, 12, 2036, 2786, 19, 3007, 13, 2882, 1927, 22862, 18, 2234, 1982, 9723, 1956, 3939, 25017, 1927, 1920, 2826, 14054, 2154, 3]}, "items": [{"id": "p_1211", "content": "Hypercholesterolemia [SEP] A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th per", "score": 1, "type": null, "tokenized_content": [2, 22862, 3, 43, 2625, 1956, 20756, 2149, 2428, 1927, 5463, 1922, 1920, 2877, 18, 2176, 1977, 3608, 1966, 43, 5463, 3113, 15547, 1920, 28463, 2079, 3]}]}
{"query": {"id": "q_1212", "content": "myopathy [SEP] A case of acute inflammatory myopathy associated with the use of pravastatin, a new hydrophilic 3-hyd", "tokenized_content": [2, 25017, 3, 43, 3087, 1927, 3939, 3769, 25017, 2458, 1956, 1920, 2485, 1927, 21227, 15337, 16, 43, 2814, 14033, 23, 17, 2993, 3]}, "items": [{"id": "p_1212", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1213", "content": "hypothyroidism [SEP] ew days after pravastatin discontinuation. A previously unknown hypothyroidism, probably due to chronic autoimmune thyroiditis, was evidenced.", "tokenized_content": [2, 19316, 3, 13812, 3000, 2256, 21227, 15337, 14775, 18, 43, 3024, 5435, 19316, 16, 6226, 2810, 1942, 3724, 8904, 6918, 3678, 16, 1982, 11400, 18, 3]}, "items": [{"id": "p_1213", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_1214", "content": "autoimmune thyroiditis [SEP] n. A previously unknown hypothyroidism, probably due to chronic autoimmune thyroiditis, was evidenced. Muscle biopsy (left gastrocnemius) revealed a p", "tokenized_content": [2, 8904, 6918, 3678, 3, 56, 18, 43, 3024, 5435, 19316, 16, 6226, 2810, 1942, 3724, 8904, 6918, 3678, 16, 1982, 11400, 18, 3760, 6831, 12, 3506, 23700, 13, 3404, 43, 3]}, "items": [{"id": "p_1214", "content": "Thyroiditis, Autoimmune [SEP] Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is ch", "score": 1, "type": null, "tokenized_content": [2, 6918, 3678, 16, 8904, 3, 3769, 2573, 1927, 1920, 6918, 8359, 2810, 1942, 8904, 3387, 4523, 1942, 18921, 8946, 1927, 1920, 8359, 18, 2176, 1977, 2016, 3]}]}
{"query": {"id": "q_1215", "content": "lovastatin [SEP] mmatory infiltrate with a prevalence of CD4+ lymphocytes. While lovastatin and simvastatin have been associated with toxic myopathy, prava", "tokenized_content": [2, 18412, 11680, 3, 29025, 27708, 19155, 1956, 43, 4077, 1927, 4095, 15, 7257, 18, 2679, 18412, 11680, 1930, 21555, 2162, 2252, 2458, 1956, 6161, 25017, 16, 21227, 7302, 3]}, "items": [{"id": "p_1215", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_1216", "content": "simvastatin [SEP] ate with a prevalence of CD4+ lymphocytes. While lovastatin and simvastatin have been associated with toxic myopathy, pravastatin-associate", "tokenized_content": [2, 21555, 3, 30280, 1956, 43, 4077, 1927, 4095, 15, 7257, 18, 2679, 18412, 11680, 1930, 21555, 2162, 2252, 2458, 1956, 6161, 25017, 16, 21227, 15337, 17, 11774, 3]}, "items": [{"id": "p_1216", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_1217", "content": "doxorubicin [SEP] Dose-effect and structure-function relationships in doxorubicin cardiomyopathy.", "tokenized_content": [2, 12377, 3, 3253, 17, 2495, 1930, 3170, 17, 2347, 5426, 1922, 12377, 14141, 18, 3]}, "items": [{"id": "p_1217", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_1218", "content": "cardiomyopathy [SEP] Dose-effect and structure-function relationships in doxorubicin cardiomyopathy.", "tokenized_content": [2, 14141, 3, 3253, 17, 2495, 1930, 3170, 17, 2347, 5426, 1922, 12377, 14141, 18, 3]}, "items": [{"id": "p_1218", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1219", "content": "cardiomyopathy [SEP] The cardiomyopathy (CM) produced by the anticancer drug doxorubicin (DXR) (Adriamy", "tokenized_content": [2, 14141, 3, 1920, 14141, 12, 3195, 13, 4152, 2007, 1920, 11515, 2838, 12377, 12, 14852, 1005, 13, 12, 25622, 26984, 3]}, "items": [{"id": "p_1219", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1220", "content": "CM [SEP] The cardiomyopathy (CM) produced by the anticancer drug doxorubicin (DXR) (Adriamycin)", "tokenized_content": [2, 3195, 3, 1920, 14141, 12, 3195, 13, 4152, 2007, 1920, 11515, 2838, 12377, 12, 14852, 1005, 13, 12, 25622, 7898, 13, 3]}, "items": [{"id": "p_1220", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1221", "content": "doxorubicin [SEP] The cardiomyopathy (CM) produced by the anticancer drug doxorubicin (DXR) (Adriamycin) provides a unique opportunity to analyze dos", "tokenized_content": [2, 12377, 3, 1920, 14141, 12, 3195, 13, 4152, 2007, 1920, 11515, 2838, 12377, 12, 14852, 1005, 13, 12, 25622, 7898, 13, 4558, 43, 5008, 9202, 1942, 7125, 4220, 3]}, "items": [{"id": "p_1221", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_1222", "content": "DXR [SEP] ardiomyopathy (CM) produced by the anticancer drug doxorubicin (DXR) (Adriamycin) provides a unique opportunity to analyze dose-eff", "tokenized_content": [2, 14852, 1005, 3, 2245, 7408, 3542, 6522, 12, 3195, 13, 4152, 2007, 1920, 11515, 2838, 12377, 12, 14852, 1005, 13, 12, 25622, 7898, 13, 4558, 43, 5008, 9202, 1942, 7125, 3]}, "items": [{"id": "p_1222", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_1223", "content": "Adriamycin [SEP] yopathy (CM) produced by the anticancer drug doxorubicin (DXR) (Adriamycin) provides a unique opportunity to analyze dose-effect and struc", "tokenized_content": [2, 25622, 7898, 3, 7419, 9112, 1012, 12, 3195, 13, 4152, 2007, 1920, 11515, 2838, 12377, 12, 14852, 1005, 13, 12, 25622, 7898, 13, 4558, 43, 5008, 9202, 1942, 7125, 3253, 3]}, "items": [{"id": "p_1223", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_1224", "content": "myocardial disease [SEP] fect and structure-function relationships during development of myocardial disease. We measured the degree of morphologic damage by ultrastructura", "tokenized_content": [2, 6497, 2573, 3, 16688, 1031, 1930, 3170, 17, 2347, 5426, 2409, 2740, 1927, 6497, 2573, 18, 2038, 3045, 1920, 4647, 1927, 19599, 4293, 2007, 5716, 6864, 9280, 3]}, "items": [{"id": "p_1224", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1225", "content": "myocardial damage [SEP] lso exhibited a curvilinear, threshold configuration. In DXR-CM myocardial damage is proportional to the degree of cytotoxic insult (DXR dose) wh", "tokenized_content": [2, 6497, 4293, 3, 6639, 1037, 5065, 43, 12578, 19204, 1933, 16, 4683, 9674, 18, 1922, 14852, 1005, 17, 3195, 6497, 4293, 1977, 8896, 1942, 1920, 4647, 1927, 8377, 20110, 12, 3]}, "items": [{"id": "p_1225", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1226", "content": "aplastic anemia [SEP] Fatal aplastic anemia following topical administration of ophthalmic chloramphenicol.", "tokenized_content": [2, 18373, 4054, 10679, 3, 11990, 18373, 4054, 10679, 2894, 12259, 4183, 1927, 21421, 20125, 18, 3]}, "items": [{"id": "p_1226", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_1227", "content": "chloramphenicol [SEP]  aplastic anemia following topical administration of ophthalmic chloramphenicol.", "tokenized_content": [2, 20125, 3, 18373, 4054, 10679, 2894, 12259, 4183, 1927, 21421, 20125, 18, 3]}, "items": [{"id": "p_1227", "content": "Chloramphenicol [SEP] An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relativel", "score": 1, "type": null, "tokenized_content": [2, 20125, 3, 1925, 7267, 2561, 3937, 2037, 5054, 1927, 22874, 26803, 5089, 5148, 1021, 1922, 17073, 1027, 2308, 5195, 4152, 6830, 2169, 18, 2176, 2258, 43, 3338, 1024, 3]}]}
{"query": {"id": "q_1228", "content": "aplastic anemia [SEP] A 73-year-old woman died of aplastic anemia less than two months after undergoing cataract extraction and b", "tokenized_content": [2, 18373, 4054, 10679, 3, 43, 5356, 17, 2476, 17, 4156, 10440, 8545, 1927, 18373, 4054, 10679, 2941, 2254, 2288, 3221, 2256, 7258, 14833, 5914, 1930, 44, 3]}, "items": [{"id": "p_1228", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_1229", "content": "cataract [SEP] n died of aplastic anemia less than two months after undergoing cataract extraction and beginning topical therapy with chloramphenicol. ", "tokenized_content": [2, 14833, 3, 56, 8545, 1927, 18373, 4054, 10679, 2941, 2254, 2288, 3221, 2256, 7258, 14833, 5914, 1930, 7828, 12259, 3181, 1956, 20125, 18, 3]}, "items": [{"id": "p_1229", "content": "Cataract [SEP] Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many ki", "score": 1, "type": null, "tokenized_content": [2, 14833, 3, 5740, 2014, 4080, 19888, 1999, 1990, 2014, 1922, 1920, 8540, 2014, 12174, 1927, 2340, 2014, 2321, 7127, 16, 25648, 9266, 2014, 7538, 19880, 18, 1920, 3086, 8191, 3]}]}
{"query": {"id": "q_1230", "content": "chloramphenicol [SEP] dergoing cataract extraction and beginning topical therapy with chloramphenicol. The first signs of pancytopenia began within one month of the ", "tokenized_content": [2, 20125, 3, 3135, 8024, 14833, 5914, 1930, 7828, 12259, 3181, 1956, 20125, 18, 1920, 2561, 6879, 1927, 5001, 2355, 12903, 10486, 2651, 2340, 2935, 1927, 1920, 3]}, "items": [{"id": "p_1230", "content": "Chloramphenicol [SEP] An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relativel", "score": 1, "type": null, "tokenized_content": [2, 20125, 3, 1925, 7267, 2561, 3937, 2037, 5054, 1927, 22874, 26803, 5089, 5148, 1021, 1922, 17073, 1027, 2308, 5195, 4152, 6830, 2169, 18, 2176, 2258, 43, 3338, 1024, 3]}]}
{"query": {"id": "q_1231", "content": "pancytopenia [SEP] inning topical therapy with chloramphenicol. The first signs of pancytopenia began within one month of the surgery. The pattern of the aplas", "tokenized_content": [2, 5001, 2355, 12903, 3, 6078, 1941, 12259, 3181, 1956, 20125, 18, 1920, 2561, 6879, 1927, 5001, 2355, 12903, 10486, 2651, 2340, 2935, 1927, 1920, 3782, 18, 1920, 3114, 1927, 1920, 3]}, "items": [{"id": "p_1231", "content": "Pancytopenia [SEP] Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5001, 2355, 12903, 3, 6179, 1927, 2136, 2559, 2024, 5362, 1927, 1920, 2877, 16, 14161, 16, 12257, 1930, 10097, 18, 3]}]}
{"query": {"id": "q_1232", "content": "bone marrow hypoplasia [SEP] henicol for ocular conditions, although two cases of reversible bone marrow hypoplasia have also been reported. Any other suspected cases of ocular to", "tokenized_content": [2, 3622, 6599, 25502, 3, 14618, 5670, 1024, 1958, 10046, 2961, 16, 2876, 2288, 2919, 1927, 10743, 3622, 6599, 25502, 2162, 2222, 2252, 2568, 18, 2967, 2303, 9407, 2919, 1927, 10046, 3]}, "items": [{"id": "p_1232", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_1233", "content": "ocular toxicity [SEP] ypoplasia have also been reported. Any other suspected cases of ocular toxicity associated with topically applied chloramphenicol should be rep", "tokenized_content": [2, 10046, 5532, 3, 21995, 14442, 2162, 2222, 2252, 2568, 18, 2967, 2303, 9407, 2919, 1927, 10046, 5532, 2458, 1956, 12259, 1954, 3730, 20125, 3066, 1998, 3073, 3]}, "items": [{"id": "p_1233", "content": "Eye Diseases [SEP] Diseases affecting the eye.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3902, 3, 3902, 7359, 1920, 5723, 18, 3]}]}
{"query": {"id": "q_1234", "content": "Bradycardia [SEP] Bradycardia due to trihexyphenidyl hydrochloride.", "tokenized_content": [2, 26192, 3, 26192, 2810, 1942, 5083, 17797, 11397, 28131, 14458, 1024, 16675, 18, 3]}, "items": [{"id": "p_1234", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1235", "content": "trihexyphenidyl hydrochloride [SEP] Bradycardia due to trihexyphenidyl hydrochloride.", "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 16675, 3, 26192, 2810, 1942, 5083, 17797, 11397, 28131, 14458, 1024, 16675, 18, 3]}, "items": [{"id": "p_1235", "content": "Trihexyphenidyl [SEP] One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2340, 1927, 1920, 20424, 8290, 20318, 10515, 2251, 1958, 2311, 1927, 10124, 3122, 4414, 1930, 2838, 17, 2719, 21346, 3553, 25238, 1923, 3]}]}
{"query": {"id": "q_1236", "content": "schizophrenic [SEP] A chronic schizophrenic patient was treated with an anticholinergic drug, trihexyphenid", "tokenized_content": [2, 28247, 3, 43, 3724, 28247, 2774, 1982, 2868, 1956, 1925, 5851, 12074, 12745, 2838, 16, 5083, 17797, 11397, 28131, 1007, 3]}, "items": [{"id": "p_1236", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_1237", "content": "trihexyphenidyl hydrochloride [SEP] schizophrenic patient was treated with an anticholinergic drug, trihexyphenidyl hydrochloride. The patient developed, paradoxically, sinus bradycardia. The r", "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 16675, 3, 28247, 2774, 1982, 2868, 1956, 1925, 5851, 12074, 12745, 2838, 16, 5083, 17797, 11397, 28131, 14458, 1024, 16675, 18, 1920, 2774, 3530, 3]}, "items": [{"id": "p_1237", "content": "Trihexyphenidyl [SEP] One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2340, 1927, 1920, 20424, 8290, 20318, 10515, 2251, 1958, 2311, 1927, 10124, 3122, 4414, 1930, 2838, 17, 2719, 21346, 3553, 25238, 1923, 3]}]}
{"query": {"id": "q_1238", "content": "bradycardia [SEP] idyl hydrochloride. The patient developed, paradoxically, sinus bradycardia. The reaction was specific to trihexyphenidyl and not to other ", "tokenized_content": [2, 26192, 3, 2313, 2199, 16675, 18, 1920, 2774, 3530, 16, 29009, 16, 9414, 26192, 18, 1920, 3227, 1982, 2487, 1942, 5083, 17797, 11397, 28131, 14458, 1024, 1930, 2084, 1942, 2303, 3]}, "items": [{"id": "p_1238", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1239", "content": "trihexyphenidyl [SEP] schizophrenic patient was treated with an anticholinergic drug, trihexyphenidyl hydrochloride. The patient developed, paradoxically, sinus brad", "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 28247, 2774, 1982, 2868, 1956, 1925, 5851, 12074, 12745, 2838, 16, 5083, 17797, 11397, 28131, 14458, 1024, 16675, 18, 1920, 2774, 3530, 16, 3]}, "items": [{"id": "p_1239", "content": "Trihexyphenidyl [SEP] One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2340, 1927, 1920, 20424, 8290, 20318, 10515, 2251, 1958, 2311, 1927, 10124, 3122, 4414, 1930, 2838, 17, 2719, 21346, 3553, 25238, 1923, 3]}]}
{"query": {"id": "q_1240", "content": "psychiatric [SEP] rgic drugs. This antidyskinetic drug is widely used in clinical psychiatric practice and physicians should be aware of this side effect.", "tokenized_content": [2, 7652, 3, 9372, 1935, 4195, 18, 2052, 30483, 2012, 24590, 2002, 2838, 1977, 5673, 2251, 1922, 2535, 7652, 4695, 1930, 6967, 3066, 1998, 11207, 1927, 2052, 4159, 2495, 18, 3]}, "items": [{"id": "p_1240", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1241", "content": "cyclosporine [SEP] Experimental cyclosporine nephrotoxicity: risk of concomitant chemotherapy.", "tokenized_content": [2, 21002, 3, 3599, 21002, 27880, 30, 2565, 1927, 8537, 5318, 18, 3]}, "items": [{"id": "p_1241", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1242", "content": "nephrotoxicity [SEP] Experimental cyclosporine nephrotoxicity: risk of concomitant chemotherapy.", "tokenized_content": [2, 27880, 3, 3599, 21002, 27880, 30, 2565, 1927, 8537, 5318, 18, 3]}, "items": [{"id": "p_1242", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1243", "content": "cyclosporine [SEP] The role of cyclosporine (CSA) alone or in combination with various chemotherapeutics in", "tokenized_content": [2, 21002, 3, 1920, 2770, 1927, 21002, 12, 12993, 13, 4298, 2014, 1922, 3921, 1956, 3425, 14124, 1036, 1922, 3]}, "items": [{"id": "p_1243", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1244", "content": "CSA [SEP] The role of cyclosporine (CSA) alone or in combination with various chemotherapeutics in the ", "tokenized_content": [2, 12993, 3, 1920, 2770, 1927, 21002, 12, 12993, 13, 4298, 2014, 1922, 3921, 1956, 3425, 14124, 1036, 1922, 1920, 3]}, "items": [{"id": "p_1244", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1245", "content": "renal toxicity [SEP] ombination with various chemotherapeutics in the development of renal toxicity was evaluated in rats. Administration of 20 mg/kg/day CSA for 4", "tokenized_content": [2, 4604, 5532, 3, 7254, 23605, 1943, 1956, 3425, 14124, 1036, 1922, 1920, 2740, 1927, 4604, 5532, 1982, 3747, 1922, 3615, 18, 4183, 1927, 2036, 2786, 19, 3621, 19, 3007, 12993, 3]}, "items": [{"id": "p_1245", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1246", "content": "nephrotoxic [SEP] administration of CSA and various chemotherapeutic drugs with a nephrotoxic potential, such as gentamicin (at therapeutic doses), amphother", "tokenized_content": [2, 22994, 10605, 3, 4183, 1927, 12993, 1930, 3425, 14124, 4195, 1956, 43, 22994, 10605, 2889, 16, 2427, 1966, 17144, 12, 2019, 4272, 5312, 13, 16, 9141, 2916, 3]}, "items": [{"id": "p_1246", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1247", "content": "gentamicin [SEP] us chemotherapeutic drugs with a nephrotoxic potential, such as gentamicin (at therapeutic doses), amphothericin B and ketoconazole, which", "tokenized_content": [2, 17144, 3, 2022, 14124, 4195, 1956, 43, 22994, 10605, 2889, 16, 2427, 1966, 17144, 12, 2019, 4272, 5312, 13, 16, 9141, 2916, 6915, 44, 1930, 21471, 12334, 6984, 16, 2154, 3]}, "items": [{"id": "p_1247", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_1248", "content": "amphothericin B [SEP] phrotoxic potential, such as gentamicin (at therapeutic doses), amphothericin B and ketoconazole, which are frequently used in immunosuppressed", "tokenized_content": [2, 9141, 2916, 6915, 44, 3, 17252, 12899, 2889, 16, 2427, 1966, 17144, 12, 2019, 4272, 5312, 13, 16, 9141, 2916, 6915, 44, 1930, 21471, 12334, 6984, 16, 2154, 2032, 5467, 3]}, "items": [{"id": "p_1248", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1249", "content": "ketoconazole [SEP]  such as gentamicin (at therapeutic doses), amphothericin B and ketoconazole, which are frequently used in immunosuppressed patients, did no", "tokenized_content": [2, 21471, 12334, 6984, 3, 2427, 1966, 17144, 12, 2019, 4272, 5312, 13, 16, 9141, 2916, 6915, 44, 1930, 21471, 12334, 6984, 16, 2154, 2032, 5467, 2251, 1922, 27996, 1919, 2132, 3]}, "items": [{"id": "p_1249", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_1250", "content": "toxicity [SEP] tion with various chemotherapeutics in the development of renal toxicity was evaluated in rats. Administration of 20 mg/kg/day CSA for 4", "tokenized_content": [2, 5532, 3, 8685, 1916, 1956, 3425, 14124, 1036, 1922, 1920, 2740, 1927, 4604, 5532, 1982, 3747, 1922, 3615, 18, 4183, 1927, 2036, 2786, 19, 3621, 19, 3007, 12993, 1958, 24, 3]}, "items": [{"id": "p_1250", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1251", "content": "Gentamicin [SEP] s, did not aggravate the CSA induced toxicity in the rat model. Gentamicin at toxic doses, however, increased CSA nephrotoxicity. Thus, th", "tokenized_content": [2, 17144, 3, 61, 16, 2811, 2084, 18206, 2010, 1920, 12993, 2719, 5532, 1922, 1920, 3067, 2322, 18, 17144, 2019, 6161, 5312, 16, 2406, 16, 2502, 12993, 27880, 18, 2842, 16, 3]}, "items": [{"id": "p_1251", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_1252", "content": "nephrotoxicity [SEP] he rat model. Gentamicin at toxic doses, however, increased CSA nephrotoxicity. Thus, the nephrotoxicity induced by CSA has a different pathog", "tokenized_content": [2, 27880, 3, 2234, 3067, 2322, 18, 17144, 2019, 6161, 5312, 16, 2406, 16, 2502, 12993, 27880, 18, 2842, 16, 1920, 27880, 2719, 2007, 12993, 2258, 43, 2413, 2450, 2021, 3]}, "items": [{"id": "p_1252", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1253", "content": "nicotine [SEP] Receptor mechanisms of nicotine-induced locomotor hyperactivity in chronic nicotine-treated rat", "tokenized_content": [2, 9303, 3, 3148, 3531, 1927, 9303, 17, 2719, 13594, 15534, 1922, 3724, 9303, 17, 2868, 3067, 3]}, "items": [{"id": "p_1253", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_1254", "content": "locomotor hyperactivity [SEP] Receptor mechanisms of nicotine-induced locomotor hyperactivity in chronic nicotine-treated rats.", "tokenized_content": [2, 13594, 15534, 3, 3148, 3531, 1927, 9303, 17, 2719, 13594, 15534, 1922, 3724, 9303, 17, 2868, 3615, 18, 3]}, "items": [{"id": "p_1254", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1255", "content": "nicotine [SEP] Rats were pretreated with saline or nicotine (1.5 mg/kg per day) by subcutaneously implanting each animal wi", "tokenized_content": [2, 9303, 3, 3615, 1985, 12152, 1956, 5977, 2014, 9303, 12, 21, 18, 25, 2786, 19, 3621, 2079, 3007, 13, 2007, 15554, 6237, 1941, 2362, 4027, 11980, 3]}, "items": [{"id": "p_1255", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_1256", "content": "spiperone [SEP]  s.c.) and (ii) measuring the density of L-[3H]nicotine and [3H]spiperone binding sites in the striatum. We observed no changes in nicoti", "tokenized_content": [2, 15776, 2116, 2290, 3, 61, 18, 45, 18, 13, 1930, 12, 2890, 13, 6711, 1920, 3824, 1927, 54, 17, 37, 7648, 39, 9303, 1930, 37, 7648, 39, 15776, 2116, 2290, 3]}, "items": [{"id": "p_1256", "content": "Spiperone [SEP] A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCH", "score": 1, "type": null, "tokenized_content": [2, 15776, 2116, 2290, 3, 43, 22075, 2308, 5134, 17616, 2290, 5729, 2551, 1942, 25107, 1930, 2303, 2712, 4300, 18, 2176, 2258, 2252, 6198, 1922, 1920, 2311, 1927, 2966, 3]}]}
{"query": {"id": "q_1257", "content": "dopamine [SEP] umber of L-[3H]nicotine binding sites and also with an elevated dopamine (DA) level in the striatum. The number of striatal [3H]spiperon", "tokenized_content": [2, 7964, 3, 25589, 1915, 1927, 54, 17, 37, 7648, 39, 9303, 2743, 3402, 1930, 2222, 1956, 1925, 4664, 7964, 12, 3692, 13, 2237, 1922, 1920, 11259, 18, 1920, 2529, 1927, 3]}, "items": [{"id": "p_1257", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1258", "content": "DA [SEP] -[3H]nicotine binding sites and also with an elevated dopamine (DA) level in the striatum. The number of striatal [3H]spiperone bi", "tokenized_content": [2, 3692, 3, 17, 37, 7648, 39, 9303, 2743, 3402, 1930, 2222, 1956, 1925, 4664, 7964, 12, 3692, 13, 2237, 1922, 1920, 11259, 18, 1920, 2529, 1927, 13165, 37, 7648, 39, 3]}, "items": [{"id": "p_1258", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1259", "content": "locomotor hyperactivity [SEP] hese results suggest that chronic nicotine-treated rats develop locomotor hyperactivity in response to nicotine initially due to increases of both the ", "tokenized_content": [2, 13594, 15534, 3, 10688, 1021, 2274, 3220, 1988, 3724, 9303, 17, 2868, 3615, 2392, 13594, 15534, 1922, 2644, 1942, 9303, 6370, 2810, 1942, 4041, 1927, 2321, 1920, 3]}, "items": [{"id": "p_1259", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1260", "content": "Hydrocortisone [SEP] Hydrocortisone-induced hypertension in humans: pressor responsiveness and symp", "tokenized_content": [2, 28184, 3, 28184, 17, 2719, 5579, 1922, 5209, 30, 3477, 1924, 10854, 1930, 29148, 3]}, "items": [{"id": "p_1260", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_1261", "content": "hypertension [SEP] Hydrocortisone-induced hypertension in humans: pressor responsiveness and sympathetic function.", "tokenized_content": [2, 5579, 3, 28184, 17, 2719, 5579, 1922, 5209, 30, 3477, 1924, 10854, 1930, 11739, 2347, 18, 3]}, "items": [{"id": "p_1261", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1262", "content": "hydrocortisone [SEP] Oral hydrocortisone increases blood pressure and enhances pressor responsiveness in", "tokenized_content": [2, 28184, 3, 4726, 28184, 4041, 2877, 3772, 1930, 9515, 3477, 1924, 10854, 1922, 3]}, "items": [{"id": "p_1262", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_1263", "content": "norepinephrine [SEP] , total peripheral resistance, forearm vascular resistance, and norepinephrine spillover to plasma in eight healthy male volunteers. Although ", "tokenized_content": [2, 16436, 3, 16, 2698, 5009, 3554, 16, 18652, 4541, 3554, 16, 1930, 16436, 23193, 2731, 1942, 3582, 1922, 5066, 4097, 4005, 9701, 18, 2876, 3]}, "items": [{"id": "p_1263", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1264", "content": "increased cardiac output [SEP] o 135 mm Hg (SED +/- 3.4, p less than 0.01), associated with an increased cardiac output (5.85-7.73 l/min, SED +/- 0.46, p less than 0.01). Total periph", "tokenized_content": [2, 2502, 4435, 6647, 3, 57, 11477, 2489, 7175, 12, 6276, 15, 19, 17, 23, 18, 24, 16, 58, 2941, 2254, 20, 18, 3287, 13, 16, 2458, 1956, 1925, 2502, 4435, 3]}, "items": [{"id": "p_1264", "content": "Cardiac Output, High [SEP] A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. Th", "score": 1, "type": null, "tokenized_content": [2, 4435, 6647, 16, 2149, 3, 43, 3360, 1927, 4664, 4435, 6647, 2810, 1942, 2961, 1927, 3108, 2502, 12173, 9749, 2014, 3028, 4435, 4612, 6647, 18, 1913, 3]}]}
{"query": {"id": "q_1265", "content": "rise in resting blood pressure [SEP] ting sympathetic nervous system activity was not increased. The rise in resting blood pressure with hydrocortisone is associated with an increased cardiac out", "tokenized_content": [2, 7164, 1922, 8513, 2877, 3772, 3, 12347, 1029, 11739, 7580, 2433, 2455, 1982, 2084, 2502, 18, 1920, 7164, 1922, 8513, 2877, 3772, 1956, 28184, 1977, 2458, 1956, 1925, 2502, 4435, 3]}, "items": [{"id": "p_1265", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1266", "content": "suprofen [SEP] Effects of suprofen on the isolated perfused rat kidney.", "tokenized_content": [2, 9320, 18514, 3, 2564, 1927, 9320, 18514, 1990, 1920, 3937, 13699, 3067, 5245, 18, 3]}, "items": [{"id": "p_1266", "content": "Suprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an a", "score": 1, "type": null, "tokenized_content": [2, 9320, 18514, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 7042, 15900, 4271, 1930, 2258, 2252, 4211, 1966, 1925, 43, 3]}]}
{"query": {"id": "q_1267", "content": "suprofen [SEP] Although suprofen has been associated with the development of acute renal failure", "tokenized_content": [2, 9320, 18514, 3, 2876, 9320, 18514, 2258, 2252, 2458, 1956, 1920, 2740, 1927, 3939, 4604, 4574, 3]}, "items": [{"id": "p_1267", "content": "Suprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an a", "score": 1, "type": null, "tokenized_content": [2, 9320, 18514, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 7042, 15900, 4271, 1930, 2258, 2252, 4211, 1966, 1925, 43, 3]}]}
{"query": {"id": "q_1268", "content": "acute renal failure [SEP] Although suprofen has been associated with the development of acute renal failure in greater than 100 subjects, the mechanism of damage remains u", "tokenized_content": [2, 3939, 4604, 4574, 3, 2876, 9320, 18514, 2258, 2252, 2458, 1956, 1920, 2740, 1927, 3939, 4604, 4574, 1922, 3430, 2254, 2813, 3297, 16, 1920, 2856, 1927, 4293, 4497, 63, 3]}, "items": [{"id": "p_1268", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1269", "content": "nephrotoxic [SEP] 0 subjects, the mechanism of damage remains unclear. The direct nephrotoxic effects of a single dose of 15 mg of suprofen were compared in ", "tokenized_content": [2, 22994, 10605, 3, 20, 3297, 16, 1920, 2856, 1927, 4293, 4497, 6390, 18, 1920, 3083, 22994, 10605, 2564, 1927, 43, 2957, 3253, 1927, 2461, 2786, 1927, 9320, 18514, 1985, 2452, 3]}, "items": [{"id": "p_1269", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1270", "content": "uric acid [SEP] ith cell-free buffer with or without the addition of 5 mg/dL of uric acid. There were no significant differences in renal sodium excretio", "tokenized_content": [2, 17607, 2687, 3, 24737, 2024, 17, 3294, 3762, 1956, 2014, 2979, 1920, 2459, 1927, 25, 2786, 19, 5268, 1927, 17607, 2687, 18, 2276, 1985, 2239, 2228, 2886, 1922, 4604, 5227, 3]}, "items": [{"id": "p_1270", "content": "Uric Acid [SEP] An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product o", "score": 1, "type": null, "tokenized_content": [2, 17607, 2687, 3, 1925, 6638, 4863, 16, 3454, 26059, 10488, 16, 1927, 20004, 1034, 17687, 1036, 2427, 1966, 26059, 1930, 5918, 24943, 18, 2176, 1977, 1920, 3948, 6638, 4863, 57, 3]}]}
{"query": {"id": "q_1271", "content": "sodium [SEP] dL of uric acid. There were no significant differences in renal sodium excretion, oxygen consumption, or urinary flow rates in kidneys", "tokenized_content": [2, 5227, 3, 5268, 1927, 17607, 2687, 18, 2276, 1985, 2239, 2228, 2886, 1922, 4604, 5227, 11093, 16, 4612, 5434, 16, 2014, 7075, 3426, 3389, 1922, 11770, 3]}, "items": [{"id": "p_1271", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1272", "content": "oxygen [SEP] here were no significant differences in renal sodium excretion, oxygen consumption, or urinary flow rates in kidneys perfused with sup", "tokenized_content": [2, 4612, 3, 3410, 1985, 2239, 2228, 2886, 1922, 4604, 5227, 11093, 16, 4612, 5434, 16, 2014, 7075, 3426, 3389, 1922, 11770, 13699, 1956, 2302, 3]}, "items": [{"id": "p_1272", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_1273", "content": "acute declines in renal function [SEP] roups over the experimental period. In summary, suprofen causes acute declines in renal function, most likely by directly altering the intrarenal distribution o", "tokenized_content": [2, 3939, 15459, 1922, 4604, 2347, 3, 5828, 2523, 2338, 1920, 3599, 3047, 18, 1922, 6099, 16, 9320, 18514, 5092, 3939, 15459, 1922, 4604, 2347, 16, 2501, 3205, 2007, 4103, 12571, 3]}, "items": [{"id": "p_1273", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1274", "content": "Cocaine [SEP] Cocaine-induced brainstem seizures and behavior.", "tokenized_content": [2, 9045, 3, 9045, 17, 2719, 14938, 10060, 1930, 3379, 18, 3]}, "items": [{"id": "p_1274", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1275", "content": "seizures [SEP] Cocaine-induced brainstem seizures and behavior.", "tokenized_content": [2, 10060, 3, 9045, 17, 2719, 14938, 10060, 1930, 3379, 18, 3]}, "items": [{"id": "p_1275", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1276", "content": "cocaine [SEP] current stimulations and by acute and chronic administration of cocaine. The electrode implant implicated one side or the other of the ", "tokenized_content": [2, 9045, 3, 3214, 28308, 1930, 2007, 3939, 1930, 3724, 4183, 1927, 9045, 18, 1920, 7730, 6237, 6835, 2340, 4159, 2014, 1920, 2303, 1927, 1920, 3]}, "items": [{"id": "p_1276", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1277", "content": "Cocaine [SEP] instem but subjects were not incapacitated by the stimulations. Cocaine (40 mg/kg) was injected subcutaneously for an acute experiment ", "tokenized_content": [2, 9045, 3, 4766, 1987, 2308, 3297, 1985, 2084, 22689, 28278, 3857, 2013, 2007, 1920, 28308, 18, 9045, 12, 3040, 2786, 19, 3621, 13, 1982, 5624, 15554, 1958, 1925, 3939, 3859, 3]}, "items": [{"id": "p_1277", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1278", "content": "hyperactivity [SEP] ted subjects. The abnormal behaviors were yawning, retrocollis, hyperactivity, hypersensitivity, \"beating drum\" behavior, squealing, head bob", "tokenized_content": [2, 15534, 3, 26080, 3297, 18, 1920, 4552, 5888, 1985, 26169, 1018, 2989, 16, 7332, 4879, 11560, 1937, 16, 15534, 16, 14625, 16, 6, 24711, 2324, 1989, 6, 3379, 16, 4687, 3]}, "items": [{"id": "p_1278", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1279", "content": "hypersensitivity [SEP] he abnormal behaviors were yawning, retrocollis, hyperactivity, hypersensitivity, \"beating drum\" behavior, squealing, head bobbing, circling, sn", "tokenized_content": [2, 14625, 3, 2234, 4552, 5888, 1985, 26169, 1018, 2989, 16, 7332, 4879, 11560, 1937, 16, 15534, 16, 14625, 16, 6, 24711, 2324, 1989, 6, 3379, 16, 4687, 5243, 1941, 16, 3]}, "items": [{"id": "p_1279", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1280", "content": "Hypersensitivity [SEP] patterns were noted between quiet and pacing behavioral states. Hypersensitivity to various auditory, tactile, and visual stimulation was presen", "tokenized_content": [2, 14625, 3, 4147, 1985, 5040, 2192, 22993, 1930, 17248, 5343, 4376, 18, 14625, 1942, 3425, 8401, 16, 18607, 16, 1930, 3737, 4177, 1982, 2244, 1917, 3]}, "items": [{"id": "p_1280", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1281", "content": "deoxycholic acid [SEP] Increased sulfation and decreased 7alpha-hydroxylation of deoxycholic acid in ethinyl estradiol-induced cholestasis in rats.", "tokenized_content": [2, 22863, 4485, 2687, 3, 2502, 5141, 1943, 1930, 3261, 9770, 13857, 2722, 17, 21319, 1927, 22863, 4485, 2687, 1922, 17180, 16323, 1024, 11513, 17, 2719, 30086, 1922, 3615, 18, 3]}, "items": [{"id": "p_1281", "content": "Deoxycholic Acid [SEP] A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as ", "score": 1, "type": null, "tokenized_content": [2, 22863, 4485, 2687, 3, 43, 9619, 2687, 5333, 2007, 4543, 4615, 2037, 6268, 2010, 18, 2176, 1977, 5394, 6765, 1956, 10646, 2014, 22769, 18, 22863, 4485, 2687, 8016, 1966, 3]}]}
{"query": {"id": "q_1282", "content": "ethinyl estradiol [SEP] ation and decreased 7alpha-hydroxylation of deoxycholic acid in ethinyl estradiol-induced cholestasis in rats.", "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 2019, 2001, 1930, 3261, 9770, 13857, 2722, 17, 21319, 1927, 22863, 4485, 2687, 1922, 17180, 16323, 1024, 11513, 17, 2719, 30086, 1922, 3615, 18, 3]}, "items": [{"id": "p_1282", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_1283", "content": "cholestasis [SEP] -hydroxylation of deoxycholic acid in ethinyl estradiol-induced cholestasis in rats.", "tokenized_content": [2, 30086, 3, 17, 21319, 1927, 22863, 4485, 2687, 1922, 17180, 16323, 1024, 11513, 17, 2719, 30086, 1922, 3615, 18, 3]}, "items": [{"id": "p_1283", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_1284", "content": "Deoxycholic acid [SEP] Deoxycholic acid conjugation, transport capacity, and metabolism were compared i", "tokenized_content": [2, 22863, 4485, 2687, 3, 22863, 4485, 2687, 14122, 16, 4860, 4796, 16, 1930, 4714, 1985, 2452, 51, 3]}, "items": [{"id": "p_1284", "content": "Deoxycholic Acid [SEP] A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as ", "score": 1, "type": null, "tokenized_content": [2, 22863, 4485, 2687, 3, 43, 9619, 2687, 5333, 2007, 4543, 4615, 2037, 6268, 2010, 18, 2176, 1977, 5394, 6765, 1956, 10646, 2014, 22769, 18, 22863, 4485, 2687, 8016, 1966, 3]}]}
{"query": {"id": "q_1285", "content": "ethinyl estradiol [SEP] transport capacity, and metabolism were compared in control and ethinyl estradiol-treated rats. Control rats were found to have a lower capacity ", "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 4860, 4796, 16, 1930, 4714, 1985, 2452, 1922, 2285, 1930, 17180, 16323, 1024, 11513, 17, 2868, 3615, 18, 2285, 3615, 1985, 2435, 1942, 2162, 43, 3]}, "items": [{"id": "p_1285", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_1286", "content": "deoxycholic acid [SEP] . Control rats were found to have a lower capacity to transport deoxycholic acid than taurodeoxycholic acid, and both were decreased by ethinyl ", "tokenized_content": [2, 22863, 4485, 2687, 3, 18, 2285, 3615, 1985, 2435, 1942, 2162, 43, 2826, 4796, 1942, 4860, 22863, 4485, 2687, 2254, 7462, 11483, 1021, 7221, 22513, 1935, 2687, 16, 1930, 2321, 3]}, "items": [{"id": "p_1286", "content": "Deoxycholic Acid [SEP] A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as ", "score": 1, "type": null, "tokenized_content": [2, 22863, 4485, 2687, 3, 43, 9619, 2687, 5333, 2007, 4543, 4615, 2037, 6268, 2010, 18, 2176, 1977, 5394, 6765, 1956, 10646, 2014, 22769, 18, 22863, 4485, 2687, 8016, 1966, 3]}]}
{"query": {"id": "q_1287", "content": "taurodeoxycholic acid [SEP] und to have a lower capacity to transport deoxycholic acid than taurodeoxycholic acid, and both were decreased by ethinyl estradiol treatment. During", "tokenized_content": [2, 7462, 11483, 1021, 7221, 22513, 1935, 2687, 3, 3075, 1942, 2162, 43, 2826, 4796, 1942, 4860, 22863, 4485, 2687, 2254, 7462, 11483, 1021, 7221, 22513, 1935, 2687, 16, 1930, 2321, 3]}, "items": [{"id": "p_1287", "content": "Taurodeoxycholic Acid [SEP] A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholago", "score": 1, "type": null, "tokenized_content": [2, 7462, 11483, 1021, 7221, 22513, 1935, 2687, 3, 43, 9619, 7012, 5333, 1922, 1920, 3568, 2007, 14122, 1927, 24849, 1956, 22769, 16, 5394, 1966, 1920, 5227, 7012, 18, 2176, 1977, 2251, 1966, 43, 6268, 10421, 3]}]}
{"query": {"id": "q_1288", "content": "sodium deoxycholate [SEP] h were decreased by ethinyl estradiol treatment. During [24-14C]sodium deoxycholate infusion, [14C]biliary bile acid secretion increased, but bile ", "tokenized_content": [2, 5227, 24849, 3, 50, 1985, 3261, 2007, 17180, 16323, 1024, 11513, 2311, 18, 2409, 37, 2686, 17, 16974, 39, 5227, 24849, 7386, 16, 37, 16974, 39, 13210, 9619, 2687, 5512, 3]}, "items": [{"id": "p_1288", "content": "Deoxycholic Acid [SEP] A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as ", "score": 1, "type": null, "tokenized_content": [2, 22863, 4485, 2687, 3, 43, 9619, 2687, 5333, 2007, 4543, 4615, 2037, 6268, 2010, 18, 2176, 1977, 5394, 6765, 1956, 10646, 2014, 22769, 18, 22863, 4485, 2687, 8016, 1966, 3]}]}
{"query": {"id": "q_1289", "content": "bile acid [SEP] ment. During [24-14C]sodium deoxycholate infusion, [14C]biliary bile acid secretion increased, but bile flow did not change significantly", "tokenized_content": [2, 9619, 2687, 3, 11567, 18, 2409, 37, 2686, 17, 16974, 39, 5227, 24849, 7386, 16, 37, 16974, 39, 13210, 9619, 2687, 5512, 2502, 16, 2308, 9619, 3426, 2811, 2084, 3185, 3]}, "items": [{"id": "p_1289", "content": "Bile Acids and Salts [SEP] Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or", "score": 1, "type": null, "tokenized_content": [2, 9619, 4576, 1930, 16028, 3, 9507, 4576, 1930, 16028, 18, 1920, 3065, 9619, 4576, 2032, 3595, 2037, 5463, 1922, 1920, 3568, 1930, 5394, 6765, 1956, 10646, 2014, 3]}]}
{"query": {"id": "q_1290", "content": "Ethinyl estradiol [SEP] nificantly in either control or ethinyl estradiol-treated rats. Ethinyl estradiol-treated animals excreted significantly less 14C as taurocholic ", "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 17719, 13611, 14598, 1012, 1922, 3108, 2285, 2014, 17180, 16323, 1024, 11513, 17, 2868, 3615, 18, 17180, 16323, 1024, 11513, 17, 2868, 3555, 22182, 2567, 3]}, "items": [{"id": "p_1290", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_1291", "content": "taurocholic acid [SEP] yl estradiol-treated animals excreted significantly less 14C as taurocholic acid than did control animals, consistent with an impairment of 7alp", "tokenized_content": [2, 7462, 24182, 4485, 2687, 3, 12111, 11513, 17, 2868, 3555, 22182, 2567, 2941, 16974, 1966, 7462, 24182, 4485, 2687, 2254, 2811, 2285, 3555, 16, 3499, 1956, 1925, 6159, 1927, 9770, 3]}, "items": [{"id": "p_1291", "content": "Taurocholic Acid [SEP] The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous anima", "score": 1, "type": null, "tokenized_content": [2, 7462, 24182, 4485, 2687, 3, 1920, 4863, 1927, 14122, 1927, 6268, 1935, 2687, 1956, 22769, 18, 2496, 5227, 7012, 1977, 1920, 18095, 24364, 1927, 1920, 9619, 1927, 14933, 2068, 9938, 2963, 1019, 3]}]}
{"query": {"id": "q_1292", "content": "ouabain [SEP] Effects of ouabain on myocardial oxygen supply and demand in patients with chronic", "tokenized_content": [2, 26274, 3, 2564, 1927, 26274, 1990, 6497, 4612, 9042, 1930, 9749, 1922, 2132, 1956, 3724, 3]}, "items": [{"id": "p_1292", "content": "Ouabain [SEP] A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants ", "score": 1, "type": null, "tokenized_content": [2, 26274, 3, 43, 21129, 3849, 7533, 2261, 7600, 1927, 23120, 2217, 1930, 26175, 4079, 1921, 16, 2926, 2037, 1920, 9869, 1927, 4943, 18547, 1963, 1957, 24689, 1031, 1957, 1930, 2303, 4793, 3]}]}
{"query": {"id": "q_1293", "content": "oxygen [SEP] Effects of ouabain on myocardial oxygen supply and demand in patients with chronic coronary artery dise", "tokenized_content": [2, 4612, 3, 2564, 1927, 26274, 1990, 6497, 4612, 9042, 1930, 9749, 1922, 2132, 1956, 3724, 5846, 5511, 2445, 3]}, "items": [{"id": "p_1293", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_1294", "content": "coronary artery disease [SEP] on myocardial oxygen supply and demand in patients with chronic coronary artery disease. A hemodynamic, volumetric, and metabolic study in patients wit", "tokenized_content": [2, 5846, 5511, 2573, 3, 1990, 6497, 4612, 9042, 1930, 9749, 1922, 2132, 1956, 3724, 5846, 5511, 2573, 18, 43, 12173, 16, 16031, 16, 1930, 4487, 2161, 1922, 2132, 16086, 3]}, "items": [{"id": "p_1294", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_1295", "content": "heart failure [SEP] emodynamic, volumetric, and metabolic study in patients without heart failure.", "tokenized_content": [2, 4003, 4574, 3, 5138, 14458, 12253, 1935, 16, 16031, 16, 1930, 4487, 2161, 1922, 2132, 2979, 4003, 4574, 18, 3]}, "items": [{"id": "p_1295", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1296", "content": "digitalis glycosides [SEP] The effects of digitalis glycosides on myocardial oxygen supply and demand are of particular intere", "tokenized_content": [2, 8225, 1937, 28170, 3, 1920, 2564, 1927, 8225, 1937, 28170, 1990, 6497, 4612, 9042, 1930, 9749, 2032, 1927, 3278, 2107, 1021, 3]}, "items": [{"id": "p_1296", "content": "Digitalis Glycosides [SEP] Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also", "score": 1, "type": null, "tokenized_content": [2, 8225, 1937, 28170, 3, 28170, 2037, 4793, 1927, 1920, 9487, 8225, 1937, 18, 2673, 1927, 2144, 2032, 4707, 1966, 21129, 24970, 1930, 2246, 17, 18346, 4820, 18, 3063, 2222, 3]}]}
{"query": {"id": "q_1297", "content": "oxygen [SEP] The effects of digitalis glycosides on myocardial oxygen supply and demand are of particular interest in the presence of", "tokenized_content": [2, 4612, 3, 1920, 2564, 1927, 8225, 1937, 28170, 1990, 6497, 4612, 9042, 1930, 9749, 2032, 1927, 3278, 4501, 1922, 1920, 2990, 1927, 3]}, "items": [{"id": "p_1297", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_1298", "content": "coronary artery disease [SEP] emand are of particular interest in the presence of obstructive coronary artery disease, but have not been measured previously in man. We assessed the ", "tokenized_content": [2, 5846, 5511, 2573, 3, 27436, 1007, 2032, 1927, 3278, 4501, 1922, 1920, 2990, 1927, 12234, 5846, 5511, 2573, 16, 2308, 2162, 2084, 2252, 3045, 3024, 1922, 2323, 18, 2038, 3683, 3]}, "items": [{"id": "p_1298", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_1299", "content": "ouabain [SEP] not been measured previously in man. We assessed the effects of ouabain (0.015 mg/kg body weight) on hemodynamic, volumetric, and metab", "tokenized_content": [2, 26274, 3, 2084, 2252, 3045, 3024, 1922, 2323, 18, 2038, 3683, 1920, 2564, 1927, 26274, 12, 20, 18, 16442, 2786, 19, 3621, 3362, 3388, 13, 1990, 12173, 16, 16031, 16, 3]}, "items": [{"id": "p_1299", "content": "Ouabain [SEP] A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants ", "score": 1, "type": null, "tokenized_content": [2, 26274, 3, 43, 21129, 3849, 7533, 2261, 7600, 1927, 23120, 2217, 1930, 26175, 4079, 1921, 16, 2926, 2037, 1920, 9869, 1927, 4943, 18547, 1963, 1957, 24689, 1031, 1957, 1930, 2303, 4793, 3]}]}
{"query": {"id": "q_1300", "content": "congestive heart failure [SEP] ts with severe chronic coronary artery disease without clinical congestive heart failure. Because the protocol was long and involved interventions which", "tokenized_content": [2, 20180, 4003, 4574, 3, 4894, 1956, 4010, 3724, 5846, 5511, 2573, 2979, 2535, 20180, 4003, 4574, 18, 2882, 1920, 4478, 1982, 2815, 1930, 3286, 4984, 2154, 3]}, "items": [{"id": "p_1300", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1301", "content": "left ventricular end-diastolic volume falls [SEP] artery disease who are not in clinical congestive heart failure left ventricular end-diastolic volume falls after ouabain administration even when it is initially normal. ", "tokenized_content": [2, 3506, 6493, 2482, 17, 9395, 3776, 12182, 3, 5511, 2573, 2746, 2032, 2084, 1922, 2535, 20180, 4003, 4574, 3506, 6493, 2482, 17, 9395, 3776, 12182, 2256, 26274, 4183, 3385, 2469, 3]}, "items": [{"id": "p_1301", "content": "Cardiac Output, Low [SEP] A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, in", "score": 1, "type": null, "tokenized_content": [2, 4435, 6647, 16, 2330, 3, 43, 3360, 1927, 28843, 2620, 2014, 11365, 4435, 6647, 2019, 6172, 2014, 2409, 3071, 18, 2176, 1977, 43, 6293, 1927, 5321, 3902, 16, 1922, 3]}]}
{"query": {"id": "q_1302", "content": "Prolongation of the QT interval [SEP] Prolongation of the QT interval related to cisapride-diltiazem interaction.", "tokenized_content": [2, 20334, 1927, 1920, 8877, 4979, 3, 20334, 1927, 1920, 8877, 4979, 2712, 1942, 5848, 21358, 2261, 17, 4333, 11574, 6931, 1035, 2835, 18, 3]}, "items": [{"id": "p_1302", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_1303", "content": "cisapride [SEP] Prolongation of the QT interval related to cisapride-diltiazem interaction.", "tokenized_content": [2, 5848, 21358, 2261, 3, 20334, 1927, 1920, 8877, 4979, 2712, 1942, 5848, 21358, 2261, 17, 4333, 11574, 6931, 1035, 2835, 18, 3]}, "items": [{"id": "p_1303", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_1304", "content": "diltiazem [SEP] Prolongation of the QT interval related to cisapride-diltiazem interaction.", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 20334, 1927, 1920, 8877, 4979, 2712, 1942, 5848, 21358, 2261, 17, 4333, 11574, 6931, 1035, 2835, 18, 3]}, "items": [{"id": "p_1304", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_1305", "content": "Cisapride [SEP] Cisapride, a cytochrome P450 3A4 (CYP3A4) substrate, is widely prescribed", "tokenized_content": [2, 5848, 21358, 2261, 3, 5848, 21358, 2261, 16, 43, 9387, 12088, 5694, 1006, 12, 20722, 13, 4510, 16, 1977, 5673, 9975, 3]}, "items": [{"id": "p_1305", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_1306", "content": "gastrointestinal motility disorders [SEP] 4 (CYP3A4) substrate, is widely prescribed for the treatment of gastrointestinal motility disorders. Prolongation of QT interval, torsades de pointes, and sudden c", "tokenized_content": [2, 8375, 9254, 4414, 3, 24, 12, 20722, 13, 4510, 16, 1977, 5673, 9975, 1958, 1920, 2311, 1927, 8375, 9254, 4414, 18, 20334, 1927, 8877, 4979, 16, 14823, 6363, 2028, 3575, 3]}, "items": [{"id": "p_1306", "content": "Ocular Motility Disorders [SEP] Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into i", "score": 1, "type": null, "tokenized_content": [2, 10046, 9254, 4414, 3, 4414, 1988, 5961, 6159, 1927, 5723, 8264, 1966, 43, 3065, 15570, 1927, 2573, 18, 2144, 2961, 2278, 1998, 5831, 2460, 51, 3]}]}
{"query": {"id": "q_1307", "content": "Prolongation of QT interval [SEP] ribed for the treatment of gastrointestinal motility disorders. Prolongation of QT interval, torsades de pointes, and sudden cardiac death have been report", "tokenized_content": [2, 20334, 1927, 8877, 4979, 3, 5216, 1919, 1958, 1920, 2311, 1927, 8375, 9254, 4414, 18, 20334, 1927, 8877, 4979, 16, 14823, 6363, 2028, 3575, 1918, 16, 1930, 12446, 4435, 3539, 3]}, "items": [{"id": "p_1307", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_1308", "content": "torsades de pointes [SEP] strointestinal motility disorders. Prolongation of QT interval, torsades de pointes, and sudden cardiac death have been reported after concomitant ", "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 4943, 8349, 9254, 4414, 18, 20334, 1927, 8877, 4979, 16, 14823, 6363, 2028, 3575, 1918, 16, 1930, 12446, 4435, 3539, 2162, 2252, 2568, 2256, 3]}, "items": [{"id": "p_1308", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_1309", "content": "sudden cardiac death [SEP] isorders. Prolongation of QT interval, torsades de pointes, and sudden cardiac death have been reported after concomitant administration with erythr", "tokenized_content": [2, 12446, 4435, 3539, 3, 4911, 8544, 2045, 18, 20334, 1927, 8877, 4979, 16, 14823, 6363, 2028, 3575, 1918, 16, 1930, 12446, 4435, 3539, 2162, 2252, 2568, 2256, 8537, 4183, 1956, 3]}, "items": [{"id": "p_1309", "content": "Death, Sudden, Cardiac [SEP] Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the w", "score": 1, "type": null, "tokenized_content": [2, 3539, 16, 12446, 16, 4435, 3, 9892, 4052, 4613, 3539, 2810, 1942, 5321, 15687, 2651, 2340, 6231, 1927, 3754, 3601, 18, 2176, 1977, 5394, 4189, 2007, 1920, 65, 3]}]}
{"query": {"id": "q_1310", "content": "erythromycin [SEP]  death have been reported after concomitant administration with erythromycin or azole antifungal agents, but not with other CYP3A4 inhibitor", "tokenized_content": [2, 22925, 3, 3539, 2162, 2252, 2568, 2256, 8537, 4183, 1956, 22925, 2014, 27381, 1952, 15216, 4820, 16, 2308, 2084, 1956, 2303, 20722, 4106, 3]}, "items": [{"id": "p_1310", "content": "Erythromycin [SEP] A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active componen", "score": 1, "type": null, "tokenized_content": [2, 22925, 3, 43, 14027, 14882, 7267, 23929, 2261, 4152, 2007, 22874, 6549, 1936, 1957, 18, 22925, 43, 1977, 3311, 2496, 3044, 3500, 3309, 1917, 3]}]}
{"query": {"id": "q_1311", "content": "azole [SEP]  reported after concomitant administration with erythromycin or azole antifungal agents, but not with other CYP3A4 inhibitors. A poss", "tokenized_content": [2, 27381, 1952, 3, 2568, 2256, 8537, 4183, 1956, 22925, 2014, 27381, 1952, 15216, 4820, 16, 2308, 2084, 1956, 2303, 20722, 4472, 18, 43, 2776, 3]}, "items": [{"id": "p_1311", "content": "Azoles [SEP] Five membered rings containing a NITROGEN atom.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27381, 2612, 3, 3628, 30261, 12750, 3165, 43, 6634, 6761, 18, 3]}]}
{"query": {"id": "q_1312", "content": "cisapride [SEP] drug interaction occurred in a 45-year-old woman who was taking cisapride for gastroesophageal reflux disorder and diltiazem, an agent th", "tokenized_content": [2, 5848, 21358, 2261, 3, 2838, 2835, 4807, 1922, 43, 3607, 17, 2476, 17, 4156, 10440, 2746, 1982, 6303, 5848, 21358, 2261, 1958, 28933, 13583, 4770, 1930, 4333, 11574, 6931, 1035, 3]}, "items": [{"id": "p_1312", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_1313", "content": "gastroesophageal reflux disorder [SEP] on occurred in a 45-year-old woman who was taking cisapride for gastroesophageal reflux disorder and diltiazem, an agent that has inhibitory effect on CYP3A4, f", "tokenized_content": [2, 28933, 13583, 4770, 3, 1990, 4807, 1922, 43, 3607, 17, 2476, 17, 4156, 10440, 2746, 1982, 6303, 5848, 21358, 2261, 1958, 28933, 13583, 4770, 1930, 4333, 11574, 6931, 1035, 16, 3]}, "items": [{"id": "p_1313", "content": "Gastroesophageal Reflux [SEP] Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGU", "score": 1, "type": null, "tokenized_content": [2, 28933, 13583, 3, 14492, 3426, 1927, 6319, 17574, 12, 6319, 2687, 13, 1930, 19, 2014, 17752, 8906, 12, 9619, 4576, 31, 6356, 17574, 13, 2460, 1920, 6583, 12901, 1032, 3]}]}
{"query": {"id": "q_1314", "content": "diltiazem [SEP] o was taking cisapride for gastroesophageal reflux disorder and diltiazem, an agent that has inhibitory effect on CYP3A4, for hypertensio", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 57, 1982, 6303, 5848, 21358, 2261, 1958, 28933, 13583, 4770, 1930, 4333, 11574, 6931, 1035, 16, 1925, 5899, 1988, 2258, 5431, 2495, 1990, 20722, 16, 3]}, "items": [{"id": "p_1314", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_1315", "content": "hypertension [SEP] d diltiazem, an agent that has inhibitory effect on CYP3A4, for hypertension. The patient was in near syncope and had QT-interval prolongati", "tokenized_content": [2, 5579, 3, 46, 4333, 11574, 6931, 1035, 16, 1925, 5899, 1988, 2258, 5431, 2495, 1990, 20722, 16, 1958, 5579, 18, 1920, 2774, 1982, 1922, 4931, 26742, 1930, 2430, 8877, 17, 3]}, "items": [{"id": "p_1315", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1316", "content": "syncope [SEP] ory effect on CYP3A4, for hypertension. The patient was in near syncope and had QT-interval prolongation. After discontinuing cisapride", "tokenized_content": [2, 26742, 3, 2014, 1012, 2495, 1990, 20722, 16, 1958, 5579, 18, 1920, 2774, 1982, 1922, 4931, 26742, 1930, 2430, 8877, 17, 4979, 20334, 18, 2256, 9035, 13768, 5848, 21358, 2261, 3]}, "items": [{"id": "p_1316", "content": "Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync", "score": 1, "type": null, "tokenized_content": [2, 26742, 3, 43, 6809, 3257, 1927, 16897, 1930, 17198, 11020, 4189, 2007, 9597, 2877, 3426, 1942, 1920, 3068, 12, 51, 18, 47, 18, 16, 3068, 7716, 13, 18, 2244, 2304, 1030, 3]}]}
{"query": {"id": "q_1317", "content": "QT-interval prolongation [SEP] P3A4, for hypertension. The patient was in near syncope and had QT-interval prolongation. After discontinuing cisapride, the QT interval returned to nor", "tokenized_content": [2, 8877, 17, 4979, 20334, 3, 9234, 16010, 16, 1958, 5579, 18, 1920, 2774, 1982, 1922, 4931, 26742, 1930, 2430, 8877, 17, 4979, 20334, 18, 2256, 9035, 13768, 5848, 21358, 2261, 3]}, "items": [{"id": "p_1317", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_1318", "content": "Paclitaxel [SEP] Paclitaxel combined with carboplatin in the first-line treatment of advanc", "tokenized_content": [2, 12404, 3, 12404, 4252, 1956, 20072, 1922, 1920, 2561, 17, 2823, 2311, 1927, 3277, 2412, 3]}, "items": [{"id": "p_1318", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_1319", "content": "carboplatin [SEP] Paclitaxel combined with carboplatin in the first-line treatment of advanced ovarian cancer.", "tokenized_content": [2, 20072, 3, 12404, 4252, 1956, 20072, 1922, 1920, 2561, 17, 2823, 2311, 1927, 5570, 6751, 2539, 18, 3]}, "items": [{"id": "p_1319", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_1320", "content": "ovarian cancer [SEP] mbined with carboplatin in the first-line treatment of advanced ovarian cancer.", "tokenized_content": [2, 6751, 2539, 3, 5667, 2373, 1956, 20072, 1922, 1920, 2561, 17, 2823, 2311, 1927, 5570, 6751, 2539, 18, 3]}, "items": [{"id": "p_1320", "content": "Ovarian Neoplasms [SEP] Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin", "score": 1, "type": null, "tokenized_content": [2, 6751, 15347, 3, 3861, 2014, 2539, 1927, 1920, 13464, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2611, 2032, 5947, 3147, 1942, 1920, 2960, 1927, 4853, 3]}]}
{"query": {"id": "q_1321", "content": "paclitaxel [SEP] In a phase I study to determine the maximum tolerated dose of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) given as a", "tokenized_content": [2, 12404, 3, 1922, 43, 3193, 51, 2161, 1942, 3415, 1920, 4419, 11117, 3253, 1927, 12404, 12, 24411, 31, 23905, 17, 25912, 4687, 27667, 12428, 16, 5946, 30119, 16, 11421, 13, 3]}, "items": [{"id": "p_1321", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_1322", "content": "Taxol [SEP]  I study to determine the maximum tolerated dose of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) given as a 3-hour", "tokenized_content": [2, 24411, 3, 51, 2161, 1942, 3415, 1920, 4419, 11117, 3253, 1927, 12404, 12, 24411, 31, 23905, 17, 25912, 4687, 27667, 12428, 16, 5946, 30119, 16, 11421, 13, 3258, 1966, 43, 3]}, "items": [{"id": "p_1322", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_1323", "content": "carboplatin [SEP] , Princeton, NJ) given as a 3-hour infusion in combination with carboplatin administered every 21 days to women with advanced ovarian cance", "tokenized_content": [2, 20072, 3, 16, 5946, 30119, 16, 11421, 13, 3258, 1966, 43, 23, 17, 6231, 7386, 1922, 3921, 1956, 20072, 5254, 4808, 2900, 3000, 1942, 3089, 1956, 5570, 6751, 2112, 1972, 3]}, "items": [{"id": "p_1323", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_1324", "content": "ovarian cancer [SEP] h carboplatin administered every 21 days to women with advanced ovarian cancer, paclitaxel doses were escalated as follows: level 1, 135 mg/m2", "tokenized_content": [2, 6751, 2539, 3, 50, 20072, 5254, 4808, 2900, 3000, 1942, 3089, 1956, 5570, 6751, 2539, 16, 12404, 5312, 1985, 15279, 1981, 1966, 6052, 30, 2237, 21, 16, 11477, 2786, 19, 3]}, "items": [{"id": "p_1324", "content": "Ovarian Neoplasms [SEP] Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin", "score": 1, "type": null, "tokenized_content": [2, 6751, 15347, 3, 3861, 2014, 2539, 1927, 1920, 13464, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2611, 2032, 5947, 3147, 1942, 1920, 2960, 1927, 4853, 3]}]}
{"query": {"id": "q_1325", "content": "toxicity [SEP] 2) have been entered into this ongoing study. The dose-limiting toxicity of the combination was myelosuppression (leukopenia, granulocyt", "tokenized_content": [2, 5532, 3, 22, 13, 2162, 2252, 10725, 2460, 2052, 8234, 2161, 18, 1920, 3253, 17, 8051, 5532, 1927, 1920, 3921, 1982, 5707, 1951, 3481, 3124, 12, 5104, 12903, 16, 9015, 3]}, "items": [{"id": "p_1325", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1326", "content": "myelosuppression [SEP] ngoing study. The dose-limiting toxicity of the combination was myelosuppression (leukopenia, granulocytopenia, and thrombocytopenia). Neurotoxi", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 4375, 9024, 1029, 2161, 18, 1920, 3253, 17, 8051, 5532, 1927, 1920, 3921, 1982, 5707, 1951, 3481, 3124, 12, 5104, 12903, 16, 9015, 3107, 12903, 3]}, "items": [{"id": "p_1326", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_1327", "content": "leukopenia [SEP] dose-limiting toxicity of the combination was myelosuppression (leukopenia, granulocytopenia, and thrombocytopenia). Neurotoxicity was lar", "tokenized_content": [2, 5104, 12903, 3, 3253, 17, 8051, 5532, 1927, 1920, 3921, 1982, 5707, 1951, 3481, 3124, 12, 5104, 12903, 16, 9015, 3107, 12903, 16, 1930, 17100, 13, 18, 18034, 1982, 6590, 3]}, "items": [{"id": "p_1327", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_1328", "content": "granulocytopenia [SEP] g toxicity of the combination was myelosuppression (leukopenia, granulocytopenia, and thrombocytopenia). Neurotoxicity was largely moderate. So ", "tokenized_content": [2, 9015, 3107, 12903, 3, 49, 5532, 1927, 1920, 3921, 1982, 5707, 1951, 3481, 3124, 12, 5104, 12903, 16, 9015, 3107, 12903, 16, 1930, 17100, 13, 18, 18034, 1982, 6318, 5086, 3]}, "items": [{"id": "p_1328", "content": "Agranulocytosis [SEP] A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 43, 3714, 1922, 1920, 2529, 1927, 22144, 31, 12, 29929, 31, 15854, 31, 1930, 8508, 13, 18, 3]}]}
{"query": {"id": "q_1329", "content": "thrombocytopenia [SEP] ination was myelosuppression (leukopenia, granulocytopenia, and thrombocytopenia). Neurotoxicity was largely moderate. So far, 14 patients are e", "tokenized_content": [2, 17100, 3, 26851, 1929, 1982, 5707, 1951, 3481, 3124, 12, 5104, 12903, 16, 9015, 3107, 12903, 16, 1930, 17100, 13, 18, 18034, 1982, 6318, 5086, 18, 2577, 5108, 16, 2607, 3]}, "items": [{"id": "p_1329", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_1330", "content": "Neurotoxicity [SEP] ppression (leukopenia, granulocytopenia, and thrombocytopenia). Neurotoxicity was largely moderate. So far, 14 patients are evaluable for res", "tokenized_content": [2, 18034, 3, 22904, 2881, 12, 5104, 12903, 16, 9015, 3107, 12903, 16, 1930, 17100, 13, 18, 18034, 1982, 6318, 5086, 18, 2577, 5108, 16, 2607, 2132, 2032, 23626, 1958, 1995, 3]}, "items": [{"id": "p_1330", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_1331", "content": "tacrolimus [SEP] Treatment of tacrolimus-related adverse effects by conversion to cyclosporine in liver ", "tokenized_content": [2, 21801, 3, 2311, 1927, 21801, 17, 2712, 5246, 2564, 2007, 7309, 1942, 21002, 1922, 3568, 3]}, "items": [{"id": "p_1331", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1332", "content": "cyclosporine [SEP] reatment of tacrolimus-related adverse effects by conversion to cyclosporine in liver transplant recipients.", "tokenized_content": [2, 21002, 3, 1964, 7647, 1927, 21801, 17, 2712, 5246, 2564, 2007, 7309, 1942, 21002, 1922, 3568, 5192, 9336, 18, 3]}, "items": [{"id": "p_1332", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1333", "content": "tacrolimus [SEP] When tacrolimus side effects persist despite dose reduction, conversion to cycl", "tokenized_content": [2, 21801, 3, 2469, 21801, 4159, 2564, 5762, 4281, 3253, 3378, 16, 7309, 1942, 3637, 3]}, "items": [{"id": "p_1333", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1334", "content": "cyclosporine [SEP] imus side effects persist despite dose reduction, conversion to cyclosporine-based immunosuppression (CyA) is necessary. We characterized ta", "tokenized_content": [2, 21002, 3, 2042, 1957, 4159, 2564, 5762, 4281, 3253, 3378, 16, 7309, 1942, 21002, 17, 2454, 15858, 12, 6002, 1019, 13, 1977, 4680, 18, 2038, 4378, 4410, 3]}, "items": [{"id": "p_1334", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1335", "content": "neurotoxicity [SEP] ) and late in 41 (58.6%). Indications for early conversion were neurotoxicity (20), (insulin-dependent) diabetes mellitus (IDDM) (5), nephrot", "tokenized_content": [2, 18034, 3, 13, 1930, 5058, 1922, 4353, 12, 4804, 18, 26, 9, 13, 18, 11615, 1958, 3120, 7309, 1985, 18034, 12, 2036, 13, 16, 12, 4122, 17, 3100, 13, 4032, 3]}, "items": [{"id": "p_1335", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_1336", "content": "(insulin-dependent) diabetes mellitus [SEP] .6%). Indications for early conversion were neurotoxicity (20), (insulin-dependent) diabetes mellitus (IDDM) (5), nephrotoxicity (3), gastrointestinal (GI) toxicity ", "tokenized_content": [2, 12, 4122, 17, 3100, 13, 4032, 9695, 3, 18, 26, 9, 13, 18, 11615, 1958, 3120, 7309, 1985, 18034, 12, 2036, 13, 16, 12, 4122, 17, 3100, 13, 4032, 9695, 3]}, "items": [{"id": "p_1336", "content": "Diabetes Mellitus, Type 1 [SEP] A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPER", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 16, 2601, 21, 3, 43, 8856, 1927, 4032, 9695, 1988, 1977, 4378, 2007, 4122, 6179, 18, 2176, 1977, 16687, 2007, 1920, 12446, 4727, 1927, 4010, 4194, 3]}]}
{"query": {"id": "q_1337", "content": "IDDM [SEP] were neurotoxicity (20), (insulin-dependent) diabetes mellitus (IDDM) (5), nephrotoxicity (3), gastrointestinal (GI) toxicity (6), a", "tokenized_content": [2, 2313, 6366, 3, 1985, 18034, 12, 2036, 13, 16, 12, 4122, 17, 3100, 13, 4032, 9695, 12, 2313, 6366, 13, 12, 25, 13, 16, 27880, 12, 23, 13, 16, 8375, 3]}, "items": [{"id": "p_1337", "content": "Diabetes Mellitus, Type 1 [SEP] A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPER", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 16, 2601, 21, 3, 43, 8856, 1927, 4032, 9695, 1988, 1977, 4378, 2007, 4122, 6179, 18, 2176, 1977, 16687, 2007, 1920, 12446, 4727, 1927, 4010, 4194, 3]}]}
{"query": {"id": "q_1338", "content": "nephrotoxicity [SEP] oxicity (20), (insulin-dependent) diabetes mellitus (IDDM) (5), nephrotoxicity (3), gastrointestinal (GI) toxicity (6), and cardiomyopathy (1)", "tokenized_content": [2, 27880, 3, 2833, 3610, 12, 2036, 13, 16, 12, 4122, 17, 3100, 13, 4032, 9695, 12, 2313, 6366, 13, 12, 25, 13, 16, 27880, 12, 23, 13, 16, 8375, 12, 3]}, "items": [{"id": "p_1338", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1339", "content": "gastrointestinal (GI) toxicity [SEP] in-dependent) diabetes mellitus (IDDM) (5), nephrotoxicity (3), gastrointestinal (GI) toxicity (6), and cardiomyopathy (1), and for late conversion were neuro", "tokenized_content": [2, 8375, 12, 7217, 13, 5532, 3, 1922, 17, 3100, 13, 4032, 9695, 12, 2313, 6366, 13, 12, 25, 13, 16, 27880, 12, 23, 13, 16, 8375, 12, 7217, 13, 5532, 3]}, "items": [{"id": "p_1339", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_1340", "content": "cardiomyopathy [SEP] 5), nephrotoxicity (3), gastrointestinal (GI) toxicity (6), and cardiomyopathy (1), and for late conversion were neurotoxicity (15), IDDM (12)", "tokenized_content": [2, 14141, 3, 25, 13, 16, 27880, 12, 23, 13, 16, 8375, 12, 7217, 13, 5532, 12, 26, 13, 16, 1930, 14141, 12, 21, 13, 16, 1930, 1958, 5058, 7309, 1985, 3]}, "items": [{"id": "p_1340", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1341", "content": "GI toxicity [SEP] version were neurotoxicity (15), IDDM (12), nephrotoxicity (3), GI toxicity (5), hepatotoxicity (6), post-transplant lmphoproliferate disea", "tokenized_content": [2, 7217, 5532, 3, 4671, 1985, 18034, 12, 2461, 13, 16, 2313, 6366, 12, 2369, 13, 16, 27880, 12, 23, 13, 16, 7217, 5532, 12, 25, 13, 16, 24126, 12, 26, 3]}, "items": [{"id": "p_1341", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_1342", "content": "hepatotoxicity [SEP] otoxicity (15), IDDM (12), nephrotoxicity (3), GI toxicity (5), hepatotoxicity (6), post-transplant lmphoproliferate disease (PTLD) (2), cardi", "tokenized_content": [2, 24126, 3, 7608, 14916, 12, 2461, 13, 16, 2313, 6366, 12, 2369, 13, 16, 27880, 12, 23, 13, 16, 7217, 5532, 12, 25, 13, 16, 24126, 12, 26, 13, 16, 3]}, "items": [{"id": "p_1342", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1343", "content": "post-transplant lmphoproliferate disease [SEP]  (12), nephrotoxicity (3), GI toxicity (5), hepatotoxicity (6), post-transplant lmphoproliferate disease (PTLD) (2), cardiomyopathy (1), hemolytic anemia (1), and pruri", "tokenized_content": [2, 2753, 17, 5192, 24984, 20855, 2226, 19582, 2057, 2573, 3, 12, 2369, 13, 16, 27880, 12, 23, 13, 16, 7217, 5532, 12, 25, 13, 16, 24126, 12, 26, 13, 16, 3]}, "items": [{"id": "p_1343", "content": "Lymphoproliferative Disorders [SEP] Disorders characterized by proliferation of lymphoid tissue, general or unspecified.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3541, 23283, 4414, 3, 4414, 4378, 2007, 4031, 1927, 11751, 2960, 16, 3335, 2014, 29628, 2828, 18, 3]}]}
{"query": {"id": "q_1344", "content": "PTLD [SEP] , hepatotoxicity (6), post-transplant lmphoproliferate disease (PTLD) (2), cardiomyopathy (1), hemolytic anemia (1), and pruritus (1", "tokenized_content": [2, 4401, 4184, 3, 16, 24126, 12, 26, 13, 16, 2753, 17, 5192, 24984, 20855, 2226, 19582, 2057, 2573, 12, 4401, 4184, 13, 12, 22, 13, 16, 14141, 12, 21, 13, 3]}, "items": [{"id": "p_1344", "content": "Lymphoproliferative Disorders [SEP] Disorders characterized by proliferation of lymphoid tissue, general or unspecified.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3541, 23283, 4414, 3, 4414, 4378, 2007, 4031, 1927, 11751, 2960, 16, 3335, 2014, 29628, 2828, 18, 3]}]}
{"query": {"id": "q_1345", "content": "hemolytic anemia [SEP] splant lmphoproliferate disease (PTLD) (2), cardiomyopathy (1), hemolytic anemia (1), and pruritus (1). All early-conversion patients showed imp", "tokenized_content": [2, 21515, 10679, 3, 5671, 2031, 24984, 20855, 2226, 19582, 2057, 2573, 12, 4401, 4184, 13, 12, 22, 13, 16, 14141, 12, 21, 13, 16, 21515, 10679, 12, 21, 13, 16, 3]}, "items": [{"id": "p_1345", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_1346", "content": "pruritus [SEP] sease (PTLD) (2), cardiomyopathy (1), hemolytic anemia (1), and pruritus (1). All early-conversion patients showed improvement/resolutio", "tokenized_content": [2, 27496, 3, 6743, 1021, 12, 4401, 4184, 13, 12, 22, 13, 16, 14141, 12, 21, 13, 16, 21515, 10679, 12, 21, 13, 16, 1930, 27496, 12, 21, 13, 18, 2136, 3]}, "items": [{"id": "p_1346", "content": "Pruritus [SEP] An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27496, 3, 1925, 10702, 20687, 1941, 15826, 1988, 9300, 1920, 11460, 1021, 1942, 10010, 2014, 18480, 1920, 4407, 1942, 5649, 13104, 18, 3]}]}
{"query": {"id": "q_1347", "content": "toxicity [SEP] Relative efficacy and toxicity of netilmicin and tobramycin in oncology patients.", "tokenized_content": [2, 5532, 3, 3338, 4348, 1930, 5532, 1927, 3254, 1970, 4913, 1921, 1930, 7551, 29085, 4636, 1922, 11605, 2132, 18, 3]}, "items": [{"id": "p_1347", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1348", "content": "netilmicin [SEP] Relative efficacy and toxicity of netilmicin and tobramycin in oncology patients.", "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 3338, 4348, 1930, 5532, 1927, 3254, 1970, 4913, 1921, 1930, 7551, 29085, 4636, 1922, 11605, 2132, 18, 3]}, "items": [{"id": "p_1348", "content": "Netilmicin [SEP] Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear an", "score": 1, "type": null, "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 8762, 18801, 4905, 4116, 2002, 21, 17, 56, 17, 7843, 10533, 1927, 19149, 7928, 16, 1925, 23029, 8028, 7267, 1956, 4615, 2551, 1942, 17144, 16, 2308, 2941, 4352, 1925, 3]}]}
{"query": {"id": "q_1349", "content": "tobramycin [SEP] Relative efficacy and toxicity of netilmicin and tobramycin in oncology patients.", "tokenized_content": [2, 7551, 29085, 4636, 3, 3338, 4348, 1930, 5532, 1927, 3254, 1970, 4913, 1921, 1930, 7551, 29085, 4636, 1922, 11605, 2132, 18, 3]}, "items": [{"id": "p_1349", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_1350", "content": "netilmicin sulfate [SEP] We prospectively compared the efficacy and safety of netilmicin sulfate or tobramycin sulfate in conjunction with piperacillin sodium i", "tokenized_content": [2, 3254, 1970, 4913, 1921, 8767, 3, 2038, 12439, 2452, 1920, 4348, 1930, 5407, 1927, 3254, 1970, 4913, 1921, 8767, 2014, 7551, 29085, 4636, 8767, 1922, 11799, 1956, 16057, 25877, 5227, 3]}, "items": [{"id": "p_1350", "content": "Netilmicin [SEP] Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear an", "score": 1, "type": null, "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 8762, 18801, 4905, 4116, 2002, 21, 17, 56, 17, 7843, 10533, 1927, 19149, 7928, 16, 1925, 23029, 8028, 7267, 1956, 4615, 2551, 1942, 17144, 16, 2308, 2941, 4352, 1925, 3]}]}
{"query": {"id": "q_1351", "content": "tobramycin sulfate [SEP] ively compared the efficacy and safety of netilmicin sulfate or tobramycin sulfate in conjunction with piperacillin sodium in 118 immunocompromise", "tokenized_content": [2, 7551, 29085, 4636, 8767, 3, 4370, 2264, 2452, 1920, 4348, 1930, 5407, 1927, 3254, 1970, 4913, 1921, 8767, 2014, 7551, 29085, 4636, 8767, 1922, 11799, 1956, 16057, 25877, 5227, 1922, 3]}, "items": [{"id": "p_1351", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_1352", "content": "piperacillin sodium [SEP] of netilmicin sulfate or tobramycin sulfate in conjunction with piperacillin sodium in 118 immunocompromised patients with presumed severe infectio", "tokenized_content": [2, 16057, 25877, 5227, 3, 1927, 3254, 1970, 4913, 1921, 8767, 2014, 7551, 29085, 4636, 8767, 1922, 11799, 1956, 16057, 25877, 5227, 1922, 10297, 21134, 2132, 1956, 15326, 4010, 15119, 3940, 3]}, "items": [{"id": "p_1352", "content": "Piperacillin [SEP] Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also us", "score": 1, "type": null, "tokenized_content": [2, 16057, 25877, 3, 8762, 18801, 4905, 4116, 2002, 16, 4949, 17, 5648, 16, 17128, 3595, 6794, 15072, 17125, 7832, 7267, 4211, 1958, 13461, 5024, 18, 2176, 1977, 2222, 2022, 3]}]}
{"query": {"id": "q_1353", "content": "infections [SEP] n sodium in 118 immunocompromised patients with presumed severe infections. The two treatment regimens were equally efficacious. Nephrotox", "tokenized_content": [2, 5024, 3, 56, 5227, 1922, 10297, 21134, 2132, 1956, 15326, 4010, 5024, 18, 1920, 2288, 2311, 9922, 1985, 9208, 15860, 18, 22994, 2325, 3]}, "items": [{"id": "p_1353", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_1354", "content": "Nephrotoxicity [SEP] nfections. The two treatment regimens were equally efficacious. Nephrotoxicity occurred in a similar proportion in patients treated with netil", "tokenized_content": [2, 27880, 3, 4651, 6037, 18, 1920, 2288, 2311, 9922, 1985, 9208, 15860, 18, 27880, 4807, 1922, 43, 2551, 4242, 1922, 2132, 2868, 1956, 3254, 1970, 3]}, "items": [{"id": "p_1354", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1355", "content": "netilmicin [SEP] We prospectively compared the efficacy and safety of netilmicin sulfate or tobramycin sulfate in conjunction with piperacillin ", "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 2038, 12439, 2452, 1920, 4348, 1930, 5407, 1927, 3254, 1970, 4913, 1921, 8767, 2014, 7551, 29085, 4636, 8767, 1922, 11799, 1956, 16057, 25877, 3]}, "items": [{"id": "p_1355", "content": "Netilmicin [SEP] Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear an", "score": 1, "type": null, "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 8762, 18801, 4905, 4116, 2002, 21, 17, 56, 17, 7843, 10533, 1927, 19149, 7928, 16, 1925, 23029, 8028, 7267, 1956, 4615, 2551, 1942, 17144, 16, 2308, 2941, 4352, 1925, 3]}]}
{"query": {"id": "q_1356", "content": "tobramycin [SEP] ively compared the efficacy and safety of netilmicin sulfate or tobramycin sulfate in conjunction with piperacillin sodium in 118 immunoco", "tokenized_content": [2, 7551, 29085, 4636, 3, 4370, 2264, 2452, 1920, 4348, 1930, 5407, 1927, 3254, 1970, 4913, 1921, 8767, 2014, 7551, 29085, 4636, 8767, 1922, 11799, 1956, 16057, 25877, 5227, 1922, 10297, 3]}, "items": [{"id": "p_1356", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_1357", "content": "Ototoxicity [SEP] n patients treated with netilmicin and tobramycin (17% vs 11%). Ototoxicity occurred in four (9.5%) of 42 netilmicin and piperacillin and i", "tokenized_content": [2, 7608, 11930, 3, 56, 2132, 2868, 1956, 3254, 1970, 4913, 1921, 1930, 7551, 29085, 4636, 12, 2752, 9, 3201, 2513, 9, 13, 18, 7608, 11930, 4807, 1922, 3006, 12, 29, 3]}, "items": [{"id": "p_1357", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_1358", "content": "piperacillin [SEP] of netilmicin sulfate or tobramycin sulfate in conjunction with piperacillin sodium in 118 immunocompromised patients with presumed severe i", "tokenized_content": [2, 16057, 25877, 3, 1927, 3254, 1970, 4913, 1921, 8767, 2014, 7551, 29085, 4636, 8767, 1922, 11799, 1956, 16057, 25877, 5227, 1922, 10297, 21134, 2132, 1956, 15326, 4010, 51, 3]}, "items": [{"id": "p_1358", "content": "Piperacillin [SEP] Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also us", "score": 1, "type": null, "tokenized_content": [2, 16057, 25877, 3, 8762, 18801, 4905, 4116, 2002, 16, 4949, 17, 5648, 16, 17128, 3595, 6794, 15072, 17125, 7832, 7267, 4211, 1958, 13461, 5024, 18, 2176, 1977, 2222, 2022, 3]}]}
{"query": {"id": "q_1359", "content": "aminoglycoside [SEP] llin-treated patients (18 of 78 vs 67 of 115). We conclude that aminoglycoside-associated ototoxicity was less severe and more often reversibl", "tokenized_content": [2, 23029, 8028, 3, 10748, 1921, 17, 2868, 2132, 12, 2654, 1927, 5440, 3201, 4838, 1927, 10709, 13, 18, 2038, 7676, 1988, 23029, 8028, 17, 2458, 7608, 11930, 1982, 2941, 4010, 3]}, "items": [{"id": "p_1359", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_1360", "content": "ototoxicity [SEP] of 78 vs 67 of 115). We conclude that aminoglycoside-associated ototoxicity was less severe and more often reversible with netilmicin than ", "tokenized_content": [2, 7608, 11930, 3, 1927, 5440, 3201, 4838, 1927, 10709, 13, 18, 2038, 7676, 1988, 23029, 8028, 17, 2458, 7608, 11930, 1982, 2941, 4010, 1930, 2253, 3868, 10743, 1956, 3254, 1970, 3]}, "items": [{"id": "p_1360", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_1361", "content": "prostaglandin [SEP] Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in ", "tokenized_content": [2, 15900, 3, 2495, 1927, 15900, 18185, 4472, 1990, 9568, 2719, 4772, 19389, 1922, 3]}, "items": [{"id": "p_1361", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1362", "content": "convulsions [SEP] f prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.", "tokenized_content": [2, 4772, 19389, 3, 48, 15900, 18185, 4472, 1990, 9568, 2719, 4772, 19389, 1922, 3615, 18, 3]}, "items": [{"id": "p_1362", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1363", "content": "prostaglandins [SEP] To investigate the relationship of prostaglandins (PGs) to seizure induction, the effects of six PG synthetase in", "tokenized_content": [2, 25674, 3, 1942, 4482, 1920, 3303, 1927, 25674, 12, 22571, 13, 1942, 11015, 4408, 16, 1920, 2564, 1927, 3798, 5306, 18185, 1922, 3]}, "items": [{"id": "p_1363", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1364", "content": "PGs [SEP] To investigate the relationship of prostaglandins (PGs) to seizure induction, the effects of six PG synthetase inhibit", "tokenized_content": [2, 22571, 3, 1942, 4482, 1920, 3303, 1927, 25674, 12, 22571, 13, 1942, 11015, 4408, 16, 1920, 2564, 1927, 3798, 5306, 18185, 2875, 3]}, "items": [{"id": "p_1364", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1365", "content": "seizure [SEP] To investigate the relationship of prostaglandins (PGs) to seizure induction, the effects of six PG synthetase inhibitors on convu", "tokenized_content": [2, 11015, 3, 1942, 4482, 1920, 3303, 1927, 25674, 12, 22571, 13, 1942, 11015, 4408, 16, 1920, 2564, 1927, 3798, 5306, 18185, 4472, 1990, 4772, 1032, 3]}, "items": [{"id": "p_1365", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1366", "content": "convulsions [SEP] izure induction, the effects of six PG synthetase inhibitors on convulsions induced by flurothyl, picrotoxin, pentetrazol (PTZ), electrosho", "tokenized_content": [2, 4772, 19389, 3, 25455, 2027, 4408, 16, 1920, 2564, 1927, 3798, 5306, 18185, 4472, 1990, 4772, 19389, 2719, 2007, 2848, 6843, 30338, 1024, 16, 7271, 6843, 9754, 16, 9412, 21193, 3]}, "items": [{"id": "p_1366", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1367", "content": "flurothyl [SEP] fects of six PG synthetase inhibitors on convulsions induced by flurothyl, picrotoxin, pentetrazol (PTZ), electroshock or bicuculline wer", "tokenized_content": [2, 2848, 6843, 30338, 1024, 3, 16688, 1973, 1927, 3798, 5306, 18185, 4472, 1990, 4772, 19389, 2719, 2007, 2848, 6843, 30338, 1024, 16, 7271, 6843, 9754, 16, 9412, 21193, 13642, 1024, 3]}, "items": [{"id": "p_1367", "content": "Flurothyl [SEP] A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock", "score": 1, "type": null, "tokenized_content": [2, 2848, 6843, 30338, 1024, 3, 43, 4772, 6325, 2031, 5985, 2251, 1922, 3599, 3555, 18, 2176, 1982, 22397, 2251, 1942, 4769, 4772, 19389, 1966, 43, 5012, 1942, 17975, 10647, 12940, 3]}]}
{"query": {"id": "q_1368", "content": "picrotoxin [SEP] x PG synthetase inhibitors on convulsions induced by flurothyl, picrotoxin, pentetrazol (PTZ), electroshock or bicuculline were evaluated.", "tokenized_content": [2, 7271, 6843, 9754, 3, 66, 5306, 18185, 4472, 1990, 4772, 19389, 2719, 2007, 2848, 6843, 30338, 1024, 16, 7271, 6843, 9754, 16, 9412, 21193, 13642, 1024, 12, 4401, 1011, 13, 3]}, "items": [{"id": "p_1368", "content": "Picrotoxin [SEP] A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated c", "score": 1, "type": null, "tokenized_content": [2, 7271, 6843, 9754, 3, 43, 22849, 9626, 2572, 2320, 8151, 2019, 7992, 17, 43, 4086, 1930, 2842, 43, 4772, 6325, 2031, 18, 7271, 6843, 9754, 7644, 1920, 7034, 17, 29093, 2687, 17, 4128, 45, 3]}]}
{"query": {"id": "q_1369", "content": "pentetrazol [SEP] ase inhibitors on convulsions induced by flurothyl, picrotoxin, pentetrazol (PTZ), electroshock or bicuculline were evaluated. Ibuprofen, s", "tokenized_content": [2, 9412, 21193, 13642, 1024, 3, 28826, 4472, 1990, 4772, 19389, 2719, 2007, 2848, 6843, 30338, 1024, 16, 7271, 6843, 9754, 16, 9412, 21193, 13642, 1024, 12, 4401, 1011, 13, 16, 3]}, "items": [{"id": "p_1369", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_1370", "content": "PTZ [SEP] s on convulsions induced by flurothyl, picrotoxin, pentetrazol (PTZ), electroshock or bicuculline were evaluated. Ibuprofen, sulind", "tokenized_content": [2, 4401, 1011, 3, 61, 1990, 4772, 19389, 2719, 2007, 2848, 6843, 30338, 1024, 16, 7271, 6843, 9754, 16, 9412, 21193, 13642, 1024, 12, 4401, 1011, 13, 16, 17975, 10647, 12940, 3]}, "items": [{"id": "p_1370", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_1371", "content": "bicuculline [SEP] ed by flurothyl, picrotoxin, pentetrazol (PTZ), electroshock or bicuculline were evaluated. Ibuprofen, sulindac, mefenamic acid, and low do", "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 3347, 2007, 2848, 6843, 30338, 1024, 16, 7271, 6843, 9754, 16, 9412, 21193, 13642, 1024, 12, 4401, 1011, 13, 16, 17975, 10647, 12940, 2014, 8876, 3]}, "items": [{"id": "p_1371", "content": "Bicuculline [SEP] An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors", "score": 1, "type": null, "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 1925, 4911, 11072, 8419, 29951, 2926, 2037, 9192, 2334, 1019, 18242, 3199, 6148, 1930, 2303, 4793, 18, 2176, 1977, 43, 10362, 8151, 1958, 7992, 17, 43, 4086, 3]}]}
{"query": {"id": "q_1372", "content": "Ibuprofen [SEP]  pentetrazol (PTZ), electroshock or bicuculline were evaluated. Ibuprofen, sulindac, mefenamic acid, and low dose meclofenamic acid incre", "tokenized_content": [2, 24089, 3, 9412, 21193, 13642, 1024, 12, 4401, 1011, 13, 16, 17975, 10647, 12940, 2014, 8876, 1978, 3199, 2053, 1985, 3747, 18, 24089, 16, 9596, 2762, 1948, 16, 17925, 11496, 3]}, "items": [{"id": "p_1372", "content": "Ibuprofen [SEP] A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24089, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 14501, 3879, 2251, 1922, 1920, 3181, 1927, 10939, 2421, 1930, 8884, 18, 3]}]}
{"query": {"id": "q_1373", "content": "sulindac [SEP] l (PTZ), electroshock or bicuculline were evaluated. Ibuprofen, sulindac, mefenamic acid, and low dose meclofenamic acid increased the l", "tokenized_content": [2, 9596, 2762, 1948, 3, 54, 12, 4401, 1011, 13, 16, 17975, 10647, 12940, 2014, 8876, 1978, 3199, 2053, 1985, 3747, 18, 24089, 16, 9596, 2762, 1948, 16, 17925, 11496, 4913, 3]}, "items": [{"id": "p_1373", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_1374", "content": "mefenamic acid [SEP] lectroshock or bicuculline were evaluated. Ibuprofen, sulindac, mefenamic acid, and low dose meclofenamic acid increased the latency-to-onset ", "tokenized_content": [2, 17925, 11496, 4913, 2687, 3, 17533, 2263, 10647, 12940, 2014, 8876, 1978, 3199, 2053, 1985, 3747, 18, 24089, 16, 9596, 2762, 1948, 16, 17925, 11496, 4913, 2687, 16, 1930, 2330, 3]}, "items": [{"id": "p_1374", "content": "Mefenamic Acid [SEP] A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyc", "score": 1, "type": null, "tokenized_content": [2, 17925, 11496, 4913, 2687, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 1956, 14501, 16, 2246, 17, 3769, 16, 1930, 2246, 18425, 3023, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21309, 3]}]}
{"query": {"id": "q_1375", "content": "meclofenamic acid [SEP] re evaluated. Ibuprofen, sulindac, mefenamic acid, and low dose meclofenamic acid increased the latency-to-onset in the flurothyl and/or PTZ mode", "tokenized_content": [2, 10685, 25927, 13514, 2687, 3, 1964, 3747, 18, 24089, 16, 9596, 2762, 1948, 16, 17925, 11496, 4913, 2687, 16, 1930, 2330, 3253, 10685, 25927, 13514, 2687, 2502, 1920, 9393, 17, 3]}, "items": [{"id": "p_1375", "content": "Meclofenamic Acid [SEP] A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynth", "score": 1, "type": null, "tokenized_content": [2, 10685, 25927, 13514, 2687, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 1956, 2246, 18425, 3023, 1930, 2246, 18218, 2281, 4209, 18, 2176, 2222, 7042, 15900, 7067, 3]}]}
{"query": {"id": "q_1376", "content": "fluorthyl [SEP] ts suggest that PGs are involved in the mechanism(s) underlying fluorthyl- and PTZ-induced convulsions, but not picrotoxin-, electroshock", "tokenized_content": [2, 5533, 28935, 1024, 3, 4894, 3220, 1988, 22571, 2032, 3286, 1922, 1920, 2856, 12, 61, 13, 5030, 5533, 28935, 1024, 17, 1930, 4401, 1011, 17, 2719, 4772, 19389, 16, 2308, 3]}, "items": [{"id": "p_1376", "content": "Flurothyl [SEP] A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock", "score": 1, "type": null, "tokenized_content": [2, 2848, 6843, 30338, 1024, 3, 43, 4772, 6325, 2031, 5985, 2251, 1922, 3599, 3555, 18, 2176, 1982, 22397, 2251, 1942, 4769, 4772, 19389, 1966, 43, 5012, 1942, 17975, 10647, 12940, 3]}]}
{"query": {"id": "q_1377", "content": "angioedema [SEP] Angiotensin-converting enzyme (ACE) inhibitor-associated angioedema of the stomach and small intestine: a case report.", "tokenized_content": [2, 29220, 16670, 3, 10814, 17, 15025, 4113, 12, 8298, 13, 4106, 17, 2458, 29220, 16670, 1927, 1920, 11399, 1930, 2858, 9887, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_1377", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_1378", "content": "hypertension [SEP] t on a 45-year old African-American female with newly diagnosed hypertension, who was started on a combination pill of amlodipine/benazapril", "tokenized_content": [2, 5579, 3, 62, 1990, 43, 3607, 17, 2476, 4156, 7050, 17, 5339, 4232, 1956, 7471, 5377, 5579, 16, 2746, 1982, 8074, 1990, 43, 3921, 16898, 1927, 9508, 26584, 19, 7129, 3]}, "items": [{"id": "p_1378", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1379", "content": "amlodipine [SEP] iagnosed hypertension, who was started on a combination pill of amlodipine/benazapril 10/5 mg. The very next day, she presented at the eme", "tokenized_content": [2, 9508, 26584, 3, 11640, 3223, 10350, 5579, 16, 2746, 1982, 8074, 1990, 43, 3921, 16898, 1927, 9508, 26584, 19, 7129, 3408, 21358, 1970, 2119, 19, 25, 2786, 18, 1920, 3345, 3]}, "items": [{"id": "p_1379", "content": "Amlodipine [SEP] A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.\n   ", "score": 1, "type": null, "tokenized_content": [2, 9508, 26584, 3, 43, 2815, 17, 8290, 11842, 18425, 5802, 5016, 4999, 14580, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 1930, 5579, 18, 3]}]}
{"query": {"id": "q_1380", "content": "benazapril [SEP] pertension, who was started on a combination pill of amlodipine/benazapril 10/5 mg. The very next day, she presented at the emergency room", "tokenized_content": [2, 7129, 3408, 21358, 1970, 3, 7548, 3212, 16, 2746, 1982, 8074, 1990, 43, 3921, 16898, 1927, 9508, 26584, 19, 7129, 3408, 21358, 1970, 2119, 19, 25, 2786, 18, 1920, 3345, 3]}, "items": [{"id": "p_1380", "content": "benazepril [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7129, 18570, 3027, 1024, 3, 3]}]}
{"query": {"id": "q_1381", "content": "abdominal pain [SEP] he very next day, she presented at the emergency room (ER) with abdominal pain, nausea and vomiting. Physical exam, complete metabolic panel, ", "tokenized_content": [2, 6900, 3594, 3, 2234, 3345, 4560, 3007, 16, 4693, 3549, 2019, 1920, 7877, 4921, 12, 2668, 13, 1956, 6900, 3594, 16, 13759, 1930, 13954, 18, 3841, 2493, 16, 4080, 4487, 3]}, "items": [{"id": "p_1381", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_1382", "content": "nausea [SEP] , she presented at the emergency room (ER) with abdominal pain, nausea and vomiting. Physical exam, complete metabolic panel, and hemo", "tokenized_content": [2, 13759, 3, 16, 4693, 3549, 2019, 1920, 7877, 4921, 12, 2668, 13, 1956, 6900, 3594, 16, 13759, 1930, 13954, 18, 3841, 2493, 16, 4080, 4487, 4812, 16, 1930, 3243, 1037, 3]}, "items": [{"id": "p_1382", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_1383", "content": "vomiting [SEP] nted at the emergency room (ER) with abdominal pain, nausea and vomiting. Physical exam, complete metabolic panel, and hemogram were in ", "tokenized_content": [2, 13954, 3, 5891, 1919, 2019, 1920, 7877, 4921, 12, 2668, 13, 1956, 6900, 3594, 16, 13759, 1930, 13954, 18, 3841, 2493, 16, 4080, 4487, 4812, 16, 1930, 3243, 7539, 1985, 3]}, "items": [{"id": "p_1383", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_1384", "content": "angioedema [SEP]  cavity. Angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema was suspected, and anti-hypertensive medications were discontin", "tokenized_content": [2, 29220, 16670, 3, 8568, 18, 10814, 17, 15025, 4113, 4106, 12, 8298, 1033, 13, 17, 2719, 29220, 16670, 1982, 9407, 16, 1930, 2246, 17, 11706, 7719, 1985, 9035, 3]}, "items": [{"id": "p_1384", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_1385", "content": "hypertensive [SEP] yme inhibitor (ACEI)-induced angioedema was suspected, and anti-hypertensive medications were discontinued. Her symptoms improved within the", "tokenized_content": [2, 11706, 3, 23143, 1021, 4106, 12, 8298, 1033, 13, 17, 2719, 29220, 16670, 1982, 9407, 16, 1930, 2246, 17, 11706, 7719, 1985, 16087, 18, 3656, 3601, 4305, 2651, 1920, 3]}, "items": [{"id": "p_1385", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1386", "content": "ascites [SEP] ovement in stomach and small bowel thickening and resolution of ascites. The recognition of angiotensin-converting enzyme (ACE) and ang", "tokenized_content": [2, 17622, 3, 4285, 2855, 1922, 11399, 1930, 2858, 9472, 16121, 1930, 4885, 1927, 17622, 18, 1920, 5708, 1927, 10814, 17, 15025, 4113, 12, 8298, 13, 1930, 3409, 3]}, "items": [{"id": "p_1386", "content": "Ascites [SEP] Accumulation or retention of free fluid within the peritoneal cavity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17622, 3, 4858, 2014, 7521, 1927, 3294, 5466, 2651, 1920, 10706, 8568, 18, 3]}]}
{"query": {"id": "q_1387", "content": "angiotensin [SEP]  bowel thickening and resolution of ascites. The recognition of angiotensin-converting enzyme (ACE) and angiotensin receptor blocker (ARB) ", "tokenized_content": [2, 10814, 3, 9472, 16121, 1930, 4885, 1927, 17622, 18, 1920, 5708, 1927, 10814, 17, 15025, 4113, 12, 8298, 13, 1930, 10814, 3148, 14580, 12, 9859, 13, 3]}, "items": [{"id": "p_1387", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_1388", "content": "intestinal [SEP] -converting enzyme (ACE) and angiotensin receptor blocker (ARB) intestinal angioedema constitutes a challenge to primary care physicians, ", "tokenized_content": [2, 6139, 3, 17, 15025, 4113, 12, 8298, 13, 1930, 10814, 3148, 14580, 12, 9859, 13, 6139, 29220, 16670, 14879, 43, 6013, 1942, 3065, 2859, 6967, 16, 3]}, "items": [{"id": "p_1388", "content": "Intestinal Diseases [SEP] Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6139, 3902, 3, 6598, 4028, 1922, 2967, 5367, 1927, 1920, 9887, 2037, 20934, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_1389", "content": "Valproic acid [SEP] Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity", "tokenized_content": [2, 23867, 1935, 2687, 3, 23867, 1935, 2687, 51, 30, 2367, 4914, 1927, 4486, 14214, 7074, 16, 3568, 5532, 3]}, "items": [{"id": "p_1389", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1390", "content": "liver toxicity [SEP] Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.", "tokenized_content": [2, 3568, 5532, 3, 23867, 1935, 2687, 51, 30, 2367, 4914, 1927, 4486, 14214, 7074, 16, 3568, 5532, 16, 1930, 23867, 1935, 2687, 9483, 2428, 1922, 3615, 18, 3]}, "items": [{"id": "p_1390", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1391", "content": "valproic acid [SEP] me course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.", "tokenized_content": [2, 23867, 1935, 2687, 3, 2142, 4914, 1927, 4486, 14214, 7074, 16, 3568, 5532, 16, 1930, 23867, 1935, 2687, 9483, 2428, 1922, 3615, 18, 3]}, "items": [{"id": "p_1391", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1392", "content": "valproic acid [SEP] A single dose of valproic acid (VPA), which is a widely used antiepileptic drug, is associated", "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 2957, 3253, 1927, 23867, 1935, 2687, 12, 19703, 13, 16, 2154, 1977, 43, 5673, 2251, 29132, 2838, 16, 1977, 2458, 3]}, "items": [{"id": "p_1392", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1393", "content": "VPA [SEP] A single dose of valproic acid (VPA), which is a widely used antiepileptic drug, is associated with", "tokenized_content": [2, 19703, 3, 43, 2957, 3253, 1927, 23867, 1935, 2687, 12, 19703, 13, 16, 2154, 1977, 43, 5673, 2251, 29132, 2838, 16, 1977, 2458, 1956, 3]}, "items": [{"id": "p_1393", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1394", "content": "15-F(2t)-isoprostane [SEP]  stress in rats, as recently demonstrated by elevated levels of 15-F(2t)-isoprostane (15-F(2t)-IsoP). To determine whether there was a temporal rela", "tokenized_content": [2, 2461, 17, 48, 12, 22, 1031, 13, 17, 10301, 16289, 2516, 3, 3071, 1922, 3615, 16, 1966, 3998, 3161, 2007, 4664, 2428, 1927, 2461, 17, 48, 12, 22, 1031, 13, 3]}, "items": [{"id": "p_1394", "content": "8-epi-prostaglandin F2alpha [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28, 17, 13872, 17, 15900, 11063, 13276, 3, 3]}]}
{"query": {"id": "q_1395", "content": "15-F(2t)-IsoP [SEP] cently demonstrated by elevated levels of 15-F(2t)-isoprostane (15-F(2t)-IsoP). To determine whether there was a temporal relationship betwee", "tokenized_content": [2, 2461, 17, 48, 12, 22, 1031, 13, 17, 10301, 3, 3208, 1954, 3161, 2007, 4664, 2428, 1927, 2461, 17, 48, 12, 22, 1031, 13, 17, 10301, 16289, 2516, 12, 2461, 3]}, "items": [{"id": "p_1395", "content": "8-epi-prostaglandin F2alpha [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28, 17, 13872, 17, 15900, 11063, 13276, 3, 3]}]}
{"query": {"id": "q_1396", "content": "hepatotoxicity [SEP] mporal relationship between VPA-associated oxidative stress and hepatotoxicity, adult male Sprague-Dawley rats were treated ip with VPA (500 m", "tokenized_content": [2, 24126, 3, 18278, 7317, 3303, 2192, 19703, 17, 2458, 5163, 3071, 1930, 24126, 16, 4160, 4005, 15684, 17, 15798, 3615, 1985, 2868, 5416, 1956, 19703, 12, 4599, 55, 3]}, "items": [{"id": "p_1396", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1397", "content": "lipid hydroperoxides [SEP] sessed by determining plasma and liver levels of 15-F(2t)-IsoP, lipid hydroperoxides (LPO), and thiobarbituric acid reactive substances (TBARs). Pla", "tokenized_content": [2, 4486, 25461, 29508, 3, 9924, 4127, 1007, 2007, 7426, 3582, 1930, 3568, 2428, 1927, 2461, 17, 48, 12, 22, 1031, 13, 17, 10301, 16, 4486, 25461, 29508, 12, 8182, 1037, 3]}, "items": [{"id": "p_1397", "content": "Lipid Peroxides [SEP] Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of ", "score": 1, "type": null, "tokenized_content": [2, 4486, 12316, 1036, 3, 12316, 1036, 4152, 1922, 1920, 2990, 1927, 43, 3294, 6917, 2007, 1920, 6638, 1927, 19172, 5934, 4576, 1922, 1920, 2024, 1922, 1920, 2990, 1927, 3]}]}
{"query": {"id": "q_1398", "content": "LPO [SEP] plasma and liver levels of 15-F(2t)-IsoP, lipid hydroperoxides (LPO), and thiobarbituric acid reactive substances (TBARs). Plasma a", "tokenized_content": [2, 8182, 1037, 3, 3582, 1930, 3568, 2428, 1927, 2461, 17, 48, 12, 22, 1031, 13, 17, 10301, 16, 4486, 25461, 29508, 12, 8182, 1037, 13, 16, 1930, 15331, 8751, 5443, 3]}, "items": [{"id": "p_1398", "content": "Lipid Peroxides [SEP] Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of ", "score": 1, "type": null, "tokenized_content": [2, 4486, 12316, 1036, 3, 12316, 1036, 4152, 1922, 1920, 2990, 1927, 43, 3294, 6917, 2007, 1920, 6638, 1927, 19172, 5934, 4576, 1922, 1920, 2024, 1922, 1920, 2990, 1927, 3]}]}
{"query": {"id": "q_1399", "content": "thiobarbituric acid reactive substances [SEP]  liver levels of 15-F(2t)-IsoP, lipid hydroperoxides (LPO), and thiobarbituric acid reactive substances (TBARs). Plasma and liver 15-F(2t)-IsoP were elevated and reach", "tokenized_content": [2, 15331, 8751, 5443, 15861, 2687, 6079, 10054, 3, 3568, 2428, 1927, 2461, 17, 48, 12, 22, 1031, 13, 17, 10301, 16, 4486, 25461, 29508, 12, 8182, 1037, 13, 16, 1930, 3]}, "items": [{"id": "p_1399", "content": "Thiobarbituric Acid Reactive Substances [SEP] Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation prod", "score": 1, "type": null, "tokenized_content": [2, 15331, 8751, 5443, 15861, 2687, 6079, 10054, 3, 2330, 17, 3272, 17, 3388, 2482, 4461, 16, 6226, 24270, 16, 1988, 2032, 5333, 2409, 1920, 12942, 1927, 4486, 14214, 21383, 3]}]}
{"query": {"id": "q_1400", "content": "TBARs [SEP] roperoxides (LPO), and thiobarbituric acid reactive substances (TBARs). Plasma and liver 15-F(2t)-IsoP were elevated and reached a pl", "tokenized_content": [2, 30225, 3, 17890, 6506, 18068, 7980, 12, 8182, 1037, 13, 16, 1930, 15331, 8751, 5443, 15861, 2687, 6079, 10054, 12, 30225, 13, 18, 3582, 1930, 3568, 2461, 17, 48, 12, 3]}, "items": [{"id": "p_1400", "content": "Thiobarbituric Acid Reactive Substances [SEP] Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation prod", "score": 1, "type": null, "tokenized_content": [2, 15331, 8751, 5443, 15861, 2687, 6079, 10054, 3, 2330, 17, 3272, 17, 3388, 2482, 4461, 16, 6226, 24270, 16, 1988, 2032, 5333, 2409, 1920, 12942, 1927, 4486, 14214, 21383, 3]}]}
{"query": {"id": "q_1401", "content": "Liver toxicity [SEP] ere not increased until 14 days (2-fold vs. control, p < 0.05). Liver toxicity was evaluated based on serum levels of alpha-glutathione S-tran", "tokenized_content": [2, 3568, 5532, 3, 22561, 2084, 2502, 4801, 2607, 3000, 12, 22, 17, 3728, 3201, 18, 2285, 16, 58, 32, 20, 18, 2914, 13, 18, 3568, 5532, 1982, 3747, 2454, 1990, 3]}, "items": [{"id": "p_1401", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1402", "content": "glutathione [SEP] 5). Liver toxicity was evaluated based on serum levels of alpha-glutathione S-transferase (alpha-GST) and by histology. Serum alpha-GST lev", "tokenized_content": [2, 9153, 3, 25, 13, 18, 3568, 5532, 1982, 3747, 2454, 1990, 3256, 2428, 1927, 4595, 17, 9153, 61, 17, 13763, 12, 4595, 17, 7793, 13, 1930, 2007, 10727, 18, 3256, 3]}, "items": [{"id": "p_1402", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_1403", "content": "inflammation [SEP] onded to hepatotoxicity as shown by the increasing incidence of inflammation of the liver capsule, necrosis, and steatosis throughout the st", "tokenized_content": [2, 4531, 3, 1990, 22250, 1942, 24126, 1966, 2522, 2007, 1920, 3605, 4332, 1927, 4531, 1927, 1920, 3568, 12174, 16, 7476, 16, 1930, 16387, 5264, 1920, 1955, 3]}, "items": [{"id": "p_1403", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_1404", "content": "necrosis [SEP]  the increasing incidence of inflammation of the liver capsule, necrosis, and steatosis throughout the study. The liver levels of beta-o", "tokenized_content": [2, 7476, 3, 1920, 3605, 4332, 1927, 4531, 1927, 1920, 3568, 12174, 16, 7476, 16, 1930, 16387, 5264, 1920, 2161, 18, 1920, 3568, 2428, 1927, 4666, 17, 57, 3]}, "items": [{"id": "p_1404", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_1405", "content": "steatosis [SEP] g incidence of inflammation of the liver capsule, necrosis, and steatosis throughout the study. The liver levels of beta-oxidation metabo", "tokenized_content": [2, 16387, 3, 49, 4332, 1927, 4531, 1927, 1920, 3568, 12174, 16, 7476, 16, 1930, 16387, 5264, 1920, 2161, 18, 1920, 3568, 2428, 1927, 4666, 17, 6638, 18447, 1037, 3]}, "items": [{"id": "p_1405", "content": "Fatty Liver [SEP] Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usua", "score": 1, "type": null, "tokenized_content": [2, 5934, 3568, 3, 4486, 8946, 1927, 1920, 6095, 19223, 2094, 3864, 1922, 43, 7463, 17, 12669, 3568, 18, 1920, 4552, 4486, 4858, 1977, 2022, 12169, 3]}]}
{"query": {"id": "q_1406", "content": "4-ene-VPA [SEP] etabolites of VPA were decreased by day 14, while the levels of 4-ene-VPA and (E)-2,4-diene-VPA were not elevated throughout the study. O", "tokenized_content": [2, 24, 17, 2066, 1021, 17, 19703, 3, 20634, 4627, 12191, 14652, 1927, 19703, 1985, 3261, 2007, 3007, 2607, 16, 2679, 1920, 2428, 1927, 24, 17, 2066, 1021, 17, 19703, 1930, 3]}, "items": [{"id": "p_1406", "content": "2-propyl-4-pentenoic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 20299, 17, 24, 17, 9412, 19789, 2687, 3, 3]}]}
{"query": {"id": "q_1407", "content": "2,4-diene-VPA [SEP] were decreased by day 14, while the levels of 4-ene-VPA and (E)-2,4-diene-VPA were not elevated throughout the study. Overall, these findings", "tokenized_content": [2, 22, 16, 24, 17, 8769, 2912, 17, 19703, 3, 1985, 3261, 2007, 3007, 2607, 16, 2679, 1920, 2428, 1927, 24, 17, 2066, 1021, 17, 19703, 1930, 12, 47, 13, 17, 3]}, "items": [{"id": "p_1407", "content": "2,4-diene-valproic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 24, 17, 8769, 2912, 17, 23867, 1935, 2687, 3, 3]}]}
{"query": {"id": "q_1408", "content": "Pheochromocytoma [SEP] Pheochromocytoma unmasked by amisulpride and tiapride.", "tokenized_content": [2, 30004, 26493, 3, 30004, 26493, 30370, 1919, 2007, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 18, 3]}, "items": [{"id": "p_1408", "content": "Pheochromocytoma [SEP] A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paragang", "score": 1, "type": null, "tokenized_content": [2, 30004, 26493, 3, 43, 5394, 8867, 16, 2486, 17, 15358, 16, 28560, 16, 4541, 2798, 1927, 3233, 9501, 2960, 1927, 1920, 10651, 18755, 2014, 11739, 8202, 6115, 1029, 3]}]}
{"query": {"id": "q_1409", "content": "amisulpride [SEP] Pheochromocytoma unmasked by amisulpride and tiapride.", "tokenized_content": [2, 15665, 20490, 13857, 20332, 1021, 3, 30004, 26493, 30370, 1919, 2007, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 18, 3]}, "items": [{"id": "p_1409", "content": "sultopride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9596, 27747, 20332, 1021, 3, 3]}]}
{"query": {"id": "q_1410", "content": "tiapride [SEP] Pheochromocytoma unmasked by amisulpride and tiapride.", "tokenized_content": [2, 22093, 2047, 2261, 3, 30004, 26493, 30370, 1919, 2007, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 18, 3]}, "items": [{"id": "p_1410", "content": "Tiapride Hydrochloride [SEP] Benzamide derivative with dopamine antagonist actions similar to SULPIRIDE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22093, 2047, 2261, 16675, 3, 7334, 5482, 10533, 1956, 7964, 8151, 7728, 2551, 1942, 9596, 10984, 20332, 1021, 18, 3]}]}
{"query": {"id": "q_1411", "content": "pheochromocytoma [SEP] OBJECTIVE: To describe the unmasking of pheochromocytoma in a patient treated with amisulpride and tiapride. CASE SUMMAR", "tokenized_content": [2, 30004, 26493, 3, 4470, 30, 1942, 5993, 1920, 30370, 1941, 1927, 30004, 26493, 1922, 43, 2774, 2868, 1956, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 18, 3087, 6220, 3]}, "items": [{"id": "p_1411", "content": "Pheochromocytoma [SEP] A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paragang", "score": 1, "type": null, "tokenized_content": [2, 30004, 26493, 3, 43, 5394, 8867, 16, 2486, 17, 15358, 16, 28560, 16, 4541, 2798, 1927, 3233, 9501, 2960, 1927, 1920, 10651, 18755, 2014, 11739, 8202, 6115, 1029, 3]}]}
{"query": {"id": "q_1412", "content": "amisulpride [SEP] ibe the unmasking of pheochromocytoma in a patient treated with amisulpride and tiapride. CASE SUMMARY: A 42-year-old white man developed a", "tokenized_content": [2, 15665, 20490, 13857, 20332, 1021, 3, 6180, 1021, 1920, 30370, 1941, 1927, 30004, 26493, 1922, 43, 2774, 2868, 1956, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 18, 3087, 3]}, "items": [{"id": "p_1412", "content": "sultopride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9596, 27747, 20332, 1021, 3, 3]}]}
{"query": {"id": "q_1413", "content": "tiapride [SEP] g of pheochromocytoma in a patient treated with amisulpride and tiapride. CASE SUMMARY: A 42-year-old white man developed acute hyperten", "tokenized_content": [2, 22093, 2047, 2261, 3, 49, 1927, 30004, 26493, 1922, 43, 2774, 2868, 1956, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 18, 3087, 6099, 30, 43, 3858, 17, 2476, 3]}, "items": [{"id": "p_1413", "content": "Tiapride Hydrochloride [SEP] Benzamide derivative with dopamine antagonist actions similar to SULPIRIDE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22093, 2047, 2261, 16675, 3, 7334, 5482, 10533, 1956, 7964, 8151, 7728, 2551, 1942, 9596, 10984, 20332, 1021, 18, 3]}]}
{"query": {"id": "q_1414", "content": "hypertension [SEP] tiapride. CASE SUMMARY: A 42-year-old white man developed acute hypertension with severe headache and vomiting 2 hours after the first doses", "tokenized_content": [2, 5579, 3, 22093, 2047, 2261, 18, 3087, 6099, 30, 43, 3858, 17, 2476, 17, 4156, 4511, 2323, 3530, 3939, 5579, 1956, 4010, 12187, 1930, 13954, 22, 3967, 2256, 1920, 2561, 3]}, "items": [{"id": "p_1414", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1415", "content": "headache [SEP]  42-year-old white man developed acute hypertension with severe headache and vomiting 2 hours after the first doses of amisulpride 100 m", "tokenized_content": [2, 12187, 3, 3858, 17, 2476, 17, 4156, 4511, 2323, 3530, 3939, 5579, 1956, 4010, 12187, 1930, 13954, 22, 3967, 2256, 1920, 2561, 5312, 1927, 15665, 20490, 13857, 20332, 1021, 2813, 3]}, "items": [{"id": "p_1415", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_1416", "content": "vomiting [SEP] white man developed acute hypertension with severe headache and vomiting 2 hours after the first doses of amisulpride 100 mg and tiaprid", "tokenized_content": [2, 13954, 3, 4511, 2323, 3530, 3939, 5579, 1956, 4010, 12187, 1930, 13954, 22, 3967, 2256, 1920, 2561, 5312, 1927, 15665, 20490, 13857, 20332, 1021, 2813, 2786, 1930, 22093, 2047, 1960, 3]}, "items": [{"id": "p_1416", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_1417", "content": "nicardipine [SEP] iately discontinued, and the patient recovered after subsequent nicardipine and verapamil treatment. Abdominal ultrasound showed an adrenal", "tokenized_content": [2, 11188, 3082, 12184, 3, 21006, 2264, 16087, 16, 1930, 1920, 2774, 8294, 2256, 4521, 11188, 3082, 12184, 1930, 23300, 2311, 18, 6900, 7424, 2594, 1925, 10651, 3]}, "items": [{"id": "p_1417", "content": "Nicardipine [SEP] A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the tr", "score": 1, "type": null, "tokenized_content": [2, 11188, 3082, 12184, 3, 43, 6828, 5016, 4999, 9847, 1005, 1956, 4961, 28194, 4615, 18, 2176, 2258, 16439, 3879, 1930, 1977, 3655, 1922, 1920, 2025, 3]}]}
{"query": {"id": "q_1418", "content": "verapamil [SEP] ued, and the patient recovered after subsequent nicardipine and verapamil treatment. Abdominal ultrasound showed an adrenal mass, and pos", "tokenized_content": [2, 23300, 3, 63, 1919, 16, 1930, 1920, 2774, 8294, 2256, 4521, 11188, 3082, 12184, 1930, 23300, 2311, 18, 6900, 7424, 2594, 1925, 10651, 3411, 16, 1930, 2159, 3]}, "items": [{"id": "p_1418", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_1419", "content": "benzamide [SEP] eochromocytoma are often associated with the use of substituted benzamide drugs, but the underlying mechanism is unknown. In our case, us", "tokenized_content": [2, 7334, 5482, 3, 23466, 6570, 13777, 27932, 2954, 2032, 3868, 2458, 1956, 1920, 2485, 1927, 11798, 7334, 5482, 4195, 16, 2308, 1920, 5030, 2856, 1977, 5435, 18, 1922, 2342, 3087, 3]}, "items": [{"id": "p_1419", "content": "benzamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7334, 5482, 3, 3]}]}
{"query": {"id": "q_1420", "content": "hypertensive [SEP] probability scale indicated a possible relationship between the hypertensive crisis and amisulpride and tiapride therapy. CONCLUSIONS: As of", "tokenized_content": [2, 11706, 3, 5485, 3536, 3391, 43, 3216, 3303, 2192, 1920, 11706, 17263, 1930, 15665, 20490, 13857, 20332, 1021, 1930, 22093, 2047, 2261, 3181, 18, 4355, 30, 1966, 1927, 3]}, "items": [{"id": "p_1420", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1421", "content": "psychosis [SEP] Quantitative drug levels in stimulant psychosis: relationship to symptom severity, catecholamines and hyperkine", "tokenized_content": [2, 15489, 3, 4794, 2838, 2428, 1922, 24252, 15489, 30, 3303, 1942, 3226, 5155, 16, 25923, 1930, 4194, 24590, 3]}, "items": [{"id": "p_1421", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_1422", "content": "catecholamines [SEP] evels in stimulant psychosis: relationship to symptom severity, catecholamines and hyperkinesia.", "tokenized_content": [2, 25923, 3, 2180, 3222, 1922, 24252, 15489, 30, 3303, 1942, 3226, 5155, 16, 25923, 1930, 4194, 26682, 18, 3]}, "items": [{"id": "p_1422", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_1423", "content": "hyperkinesia [SEP] psychosis: relationship to symptom severity, catecholamines and hyperkinesia.", "tokenized_content": [2, 4194, 26682, 3, 15489, 30, 3303, 1942, 3226, 5155, 16, 25923, 1930, 4194, 26682, 18, 3]}, "items": [{"id": "p_1423", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1424", "content": "catecholamines [SEP] ne the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric eme", "tokenized_content": [2, 25923, 3, 2069, 1920, 3303, 2192, 4794, 24252, 2838, 2428, 16, 25923, 16, 1930, 16651, 3601, 16, 24354, 2132, 1922, 43, 7652, 2391, 1021, 3]}, "items": [{"id": "p_1424", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_1425", "content": "psychotic symptoms [SEP] between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a di", "tokenized_content": [2, 16651, 3601, 3, 2192, 4794, 24252, 2838, 2428, 16, 25923, 16, 1930, 16651, 3601, 16, 24354, 2132, 1922, 43, 7652, 7877, 5948, 1956, 43, 2137, 3]}, "items": [{"id": "p_1425", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_1426", "content": "psychiatric [SEP]  catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-i", "tokenized_content": [2, 7652, 3, 25923, 16, 1930, 16651, 3601, 16, 24354, 2132, 1922, 43, 7652, 7877, 5948, 1956, 43, 3574, 1927, 19057, 17, 2014, 9045, 17, 51, 3]}, "items": [{"id": "p_1426", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1427", "content": "amphetamine [SEP] patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and ", "tokenized_content": [2, 19057, 3, 2132, 1922, 43, 7652, 7877, 5948, 1956, 43, 3574, 1927, 19057, 17, 2014, 9045, 17, 2719, 15489, 1985, 14213, 16, 1930, 3582, 1930, 3]}, "items": [{"id": "p_1427", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1428", "content": "cocaine [SEP] ychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and urine were c", "tokenized_content": [2, 9045, 3, 22386, 7969, 16036, 7877, 5948, 1956, 43, 3574, 1927, 19057, 17, 2014, 9045, 17, 2719, 15489, 1985, 14213, 16, 1930, 3582, 1930, 6960, 1985, 45, 3]}, "items": [{"id": "p_1428", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1429", "content": "psychosis [SEP] ncy service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and urine were collected for quant", "tokenized_content": [2, 15489, 3, 5301, 1012, 5948, 1956, 43, 3574, 1927, 19057, 17, 2014, 9045, 17, 2719, 15489, 1985, 14213, 16, 1930, 3582, 1930, 6960, 1985, 3651, 1958, 9878, 3]}, "items": [{"id": "p_1429", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_1430", "content": "catecholamine [SEP] ne the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric em", "tokenized_content": [2, 23483, 3, 2069, 1920, 3303, 2192, 4794, 24252, 2838, 2428, 16, 25923, 16, 1930, 16651, 3601, 16, 24354, 2132, 1922, 43, 7652, 2391, 3]}, "items": [{"id": "p_1430", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_1431", "content": "Methamphetamine [SEP] e assays of stimulant drug and catecholamine metabolite levels. Methamphetamine or amphetamine levels were related to several psychopathology s", "tokenized_content": [2, 20375, 3, 47, 4614, 1927, 24252, 2838, 1930, 23483, 9483, 2428, 18, 20375, 2014, 19057, 2428, 1985, 2712, 1942, 2980, 16425, 61, 3]}, "items": [{"id": "p_1431", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_1432", "content": "hyperkinesia [SEP] s were related to several psychopathology scores and the global hyperkinesia rating. HVA levels were related to global hyperkinesia but not ", "tokenized_content": [2, 4194, 26682, 3, 61, 1985, 2712, 1942, 2980, 16425, 3888, 1930, 1920, 4906, 4194, 26682, 7276, 18, 12948, 1019, 2428, 1985, 2712, 1942, 4906, 4194, 26682, 2308, 2084, 3]}, "items": [{"id": "p_1432", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1433", "content": "stereotypies [SEP] y a role, intensity of stimulant-induced psychotic symptoms and stereotypies appears to be at least in part dose-related.", "tokenized_content": [2, 18028, 2085, 2062, 3, 67, 43, 2770, 16, 4266, 1927, 24252, 17, 2719, 16651, 3601, 1930, 18028, 2085, 2062, 5107, 1942, 1998, 2019, 3464, 1922, 3131, 3253, 17, 2712, 18, 3]}, "items": [{"id": "p_1433", "content": "Stereotypic Movement Disorder [SEP] Motor behavior that is repetitive, often seemingly driven, and nonfunctional. This behavior markedly interferes with normal acti", "score": 1, "type": null, "tokenized_content": [2, 18028, 2085, 1935, 5829, 4770, 3, 4842, 3379, 1988, 1977, 12089, 16, 3868, 20258, 6446, 16, 1930, 19136, 20839, 18, 2052, 3379, 7686, 20766, 1956, 2791, 4033, 1033, 3]}]}
{"query": {"id": "q_1434", "content": "asystolic [SEP] Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with hig", "tokenized_content": [2, 1966, 2298, 4485, 3, 7083, 1966, 2298, 4485, 4435, 8048, 2256, 4333, 11574, 6931, 1035, 21090, 31, 15371, 1956, 21340, 3]}, "items": [{"id": "p_1434", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1435", "content": "cardiac arrest [SEP] Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intraven", "tokenized_content": [2, 4435, 8048, 3, 7083, 1966, 2298, 4485, 4435, 8048, 2256, 4333, 11574, 6931, 1035, 21090, 31, 15371, 1956, 2149, 3253, 6306, 1917, 3]}, "items": [{"id": "p_1435", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1436", "content": "diltiazem [SEP] Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 7083, 1966, 2298, 4485, 4435, 8048, 2256, 4333, 11574, 6931, 1035, 21090, 31, 15371, 1956, 2149, 3253, 7307, 5016, 18, 3]}, "items": [{"id": "p_1436", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_1437", "content": "overdose [SEP] Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.", "tokenized_content": [2, 21090, 3, 7083, 1966, 2298, 4485, 4435, 8048, 2256, 4333, 11574, 6931, 1035, 21090, 31, 15371, 1956, 2149, 3253, 7307, 5016, 18, 3]}, "items": [{"id": "p_1437", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_1438", "content": "calcium [SEP] er diltiazem overdose; resuscitation with high dose intravenous calcium.", "tokenized_content": [2, 5016, 3, 2668, 4333, 11574, 6931, 1035, 21090, 31, 15371, 1956, 2149, 3253, 7307, 5016, 18, 3]}, "items": [{"id": "p_1438", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1439", "content": "overdose [SEP] A 51 year old man took a mixed overdose including 1.8-3.6 g of diltiazem, paracetamol, aspirin, isosorb", "tokenized_content": [2, 21090, 3, 43, 4892, 2476, 4156, 2323, 8659, 43, 4985, 21090, 2710, 21, 18, 28, 17, 23, 18, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 16, 12396, 16, 3]}, "items": [{"id": "p_1439", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_1440", "content": "diltiazem [SEP] A 51 year old man took a mixed overdose including 1.8-3.6 g of diltiazem, paracetamol, aspirin, isosorbide nitrate, and alcohol. He init", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 4892, 2476, 4156, 2323, 8659, 43, 4985, 21090, 2710, 21, 18, 28, 17, 23, 18, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 3]}, "items": [{"id": "p_1440", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_1441", "content": "paracetamol [SEP] old man took a mixed overdose including 1.8-3.6 g of diltiazem, paracetamol, aspirin, isosorbide nitrate, and alcohol. He initially present", "tokenized_content": [2, 27021, 3, 4156, 2323, 8659, 43, 4985, 21090, 2710, 21, 18, 28, 17, 23, 18, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 16, 12396, 16, 4911, 2204, 16007, 3]}, "items": [{"id": "p_1441", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_1442", "content": "aspirin [SEP] a mixed overdose including 1.8-3.6 g of diltiazem, paracetamol, aspirin, isosorbide nitrate, and alcohol. He initially presented to hos", "tokenized_content": [2, 12396, 3, 43, 4985, 21090, 2710, 21, 18, 28, 17, 23, 18, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 16, 12396, 16, 4911, 2204, 16007, 2261, 12628, 16, 3]}, "items": [{"id": "p_1442", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_1443", "content": "isosorbide [SEP] verdose including 1.8-3.6 g of diltiazem, paracetamol, aspirin, isosorbide nitrate, and alcohol. He initially presented to hospital after ", "tokenized_content": [2, 4911, 2204, 16007, 2261, 3, 3566, 22389, 4127, 2710, 21, 18, 28, 17, 23, 18, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 16, 12396, 16, 4911, 2204, 16007, 3]}, "items": [{"id": "p_1443", "content": "Isosorbide [SEP] 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4911, 2204, 16007, 2261, 3, 21, 16, 24, 30, 23, 16, 26, 17, 25141, 21677, 2584, 1931, 46, 17, 3351, 8148, 18, 13944, 22937, 13951, 26829, 2251, 4994, 1942, 2297, 24408, 31, 2222, 2251, 1922, 12106, 18, 3]}]}
{"query": {"id": "q_1444", "content": "nitrate [SEP] luding 1.8-3.6 g of diltiazem, paracetamol, aspirin, isosorbide nitrate, and alcohol. He initially presented to hospital after six hour", "tokenized_content": [2, 12628, 3, 30118, 1941, 21, 18, 28, 17, 23, 18, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 16, 12396, 16, 4911, 2204, 16007, 2261, 12628, 16, 1930, 4284, 3]}, "items": [{"id": "p_1444", "content": "Nitrates [SEP] Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12628, 1036, 3, 13849, 2014, 6805, 16028, 1930, 16785, 1927, 10233, 2687, 18, 2144, 4300, 5531, 1920, 20112, 17, 6917, 18, 3]}]}
{"query": {"id": "q_1445", "content": "alcohol [SEP] 6 g of diltiazem, paracetamol, aspirin, isosorbide nitrate, and alcohol. He initially presented to hospital after six hours with mild h", "tokenized_content": [2, 4284, 3, 26, 49, 1927, 4333, 11574, 6931, 1035, 16, 27021, 16, 12396, 16, 4911, 2204, 16007, 2261, 12628, 16, 1930, 4284, 18, 2234, 6370, 3549, 1942, 3461, 2256, 3798, 3]}, "items": [{"id": "p_1445", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_1446", "content": "hypotension [SEP] l. He initially presented to hospital after six hours with mild hypotension and was treated with activated charcoal and intravenous fluids.", "tokenized_content": [2, 16453, 3, 54, 18, 2234, 6370, 3549, 1942, 3461, 2256, 3798, 3967, 1956, 5809, 16453, 1930, 1982, 2868, 1956, 4128, 27466, 1930, 7307, 13315, 18, 3]}, "items": [{"id": "p_1446", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1447", "content": "tonic-clonic seizures [SEP] luids. Eighteen hours after the overdose he had two generalised tonic-clonic seizures. The patient remained unresponsive with junctional bradycardia,", "tokenized_content": [2, 16887, 17, 6138, 1935, 10060, 3, 10908, 3753, 18, 20461, 3967, 2256, 1920, 21090, 2234, 2430, 2288, 29822, 16887, 17, 6138, 1935, 10060, 18, 1920, 2774, 5410, 27327, 1956, 21226, 3]}, "items": [{"id": "p_1447", "content": "Epilepsy, Tonic-Clonic [SEP] A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 16887, 17, 6138, 1935, 3, 43, 9612, 11015, 4770, 4378, 2007, 7457, 3044, 4842, 10060, 18, 1920, 3754, 5310, 16887, 3193, 1977, 4961, 2007, 13717, 3]}]}
{"query": {"id": "q_1448", "content": "bradycardia [SEP] nic seizures. The patient remained unresponsive with junctional bradycardia, unrecordable blood pressure, and then became asystolic. He was", "tokenized_content": [2, 26192, 3, 11188, 10060, 18, 1920, 2774, 5410, 27327, 1956, 21226, 26192, 16, 23306, 2538, 2115, 2877, 3772, 16, 1930, 2759, 7935, 1966, 2298, 4485, 18, 2234, 1982, 3]}, "items": [{"id": "p_1448", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1449", "content": "asystolic [SEP] ional bradycardia, unrecordable blood pressure, and then became asystolic. He was resuscitated with high dose (13.5 g) intravenous calciu", "tokenized_content": [2, 1966, 2298, 4485, 3, 4755, 1923, 26192, 16, 23306, 2538, 2115, 2877, 3772, 16, 1930, 2759, 7935, 1966, 2298, 4485, 18, 2234, 1982, 14037, 19633, 1956, 2149, 3253, 12, 2590, 3]}, "items": [{"id": "p_1449", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1450", "content": "calcium [SEP] stolic. He was resuscitated with high dose (13.5 g) intravenous calcium and adrenaline (epinephrine). He required inotropic support and", "tokenized_content": [2, 5016, 3, 13046, 3742, 18, 2234, 1982, 14037, 19633, 1956, 2149, 3253, 12, 2590, 18, 25, 49, 13, 7307, 5016, 1930, 10651, 2053, 12, 19280, 13, 18, 2234, 3414, 28853, 3]}, "items": [{"id": "p_1450", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1451", "content": "adrenaline [SEP] as resuscitated with high dose (13.5 g) intravenous calcium and adrenaline (epinephrine). He required inotropic support and temporary paci", "tokenized_content": [2, 10651, 2053, 3, 1966, 14037, 19633, 1956, 2149, 3253, 12, 2590, 18, 25, 49, 13, 7307, 5016, 1930, 10651, 2053, 12, 19280, 13, 18, 2234, 3414, 28853, 3373, 1930, 15301, 3]}, "items": [{"id": "p_1451", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1452", "content": "epinephrine [SEP] ted with high dose (13.5 g) intravenous calcium and adrenaline (epinephrine). He required inotropic support and temporary pacing over the n", "tokenized_content": [2, 19280, 3, 26080, 1956, 2149, 3253, 12, 2590, 18, 25, 49, 13, 7307, 5016, 1930, 10651, 2053, 12, 19280, 13, 18, 2234, 3414, 28853, 3373, 1930, 15301, 17248, 2338, 1920, 3]}, "items": [{"id": "p_1452", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1453", "content": "asystole [SEP] py in severe diltiazem overdose, particularly with the onset of asystole. It should be considered early in cases of cardiac arrest after", "tokenized_content": [2, 1966, 2298, 2456, 3, 6085, 1922, 4010, 4333, 11574, 6931, 1035, 21090, 16, 4443, 1956, 1920, 4727, 1927, 1966, 2298, 2456, 18, 2176, 3066, 1998, 3311, 3120, 1922, 2919, 1927, 3]}, "items": [{"id": "p_1453", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1454", "content": "cardiac arrest [SEP] he onset of asystole. It should be considered early in cases of cardiac arrest after diltiazem overdose. The case also highlights the problems", "tokenized_content": [2, 4435, 8048, 3, 2234, 4727, 1927, 1966, 2298, 2456, 18, 2176, 3066, 1998, 3311, 3120, 1922, 2919, 1927, 4435, 8048, 2256, 4333, 11574, 6931, 1035, 21090, 18, 1920, 3087, 2222, 3]}, "items": [{"id": "p_1454", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1455", "content": "toxicity [SEP] em overdose. The case also highlights the problems with delayed toxicity when whole bowel irrigation is not administered.", "tokenized_content": [2, 5532, 3, 2391, 21090, 18, 1920, 3087, 2222, 10668, 1920, 4951, 1956, 7083, 5532, 2469, 4292, 9472, 18224, 1977, 2084, 5254, 18, 3]}, "items": [{"id": "p_1455", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1456", "content": "Renal papillary necrosis [SEP] Renal papillary necrosis due to naproxen.", "tokenized_content": [2, 4604, 15787, 7476, 3, 4604, 15787, 7476, 2810, 1942, 14290, 12222, 1917, 18, 3]}, "items": [{"id": "p_1456", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_1457", "content": "naproxen [SEP] Renal papillary necrosis due to naproxen.", "tokenized_content": [2, 14290, 12222, 1917, 3, 4604, 15787, 7476, 2810, 1942, 14290, 12222, 1917, 18, 3]}, "items": [{"id": "p_1457", "content": "Naproxen [SEP] An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatmen", "score": 1, "type": null, "tokenized_content": [2, 14290, 12222, 1917, 3, 1925, 2246, 17, 3769, 5899, 1956, 14501, 1930, 2246, 18425, 3023, 3879, 18, 2321, 1920, 2687, 1930, 2496, 5227, 7012, 2032, 2251, 1922, 1920, 2297, 19047, 3]}]}
{"query": {"id": "q_1458", "content": "rheumatoid arthritis [SEP] A 31-year-old man with rheumatoid arthritis, who had previously been treated with sulindac, fenoprofen calc", "tokenized_content": [2, 13053, 8884, 3, 43, 3470, 17, 2476, 17, 4156, 2323, 1956, 13053, 8884, 16, 2746, 2430, 3024, 2252, 2868, 1956, 9596, 2762, 1948, 16, 15096, 12964, 14946, 2799, 3]}, "items": [{"id": "p_1458", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_1459", "content": "sulindac [SEP] with rheumatoid arthritis, who had previously been treated with sulindac, fenoprofen calcium, high dose salicylates and gold salts, deve", "tokenized_content": [2, 9596, 2762, 1948, 3, 1956, 13053, 8884, 16, 2746, 2430, 3024, 2252, 2868, 1956, 9596, 2762, 1948, 16, 15096, 12964, 14946, 5016, 16, 2149, 3253, 20734, 9075, 1036, 1930, 6557, 3]}, "items": [{"id": "p_1459", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_1460", "content": "fenoprofen calcium [SEP] atoid arthritis, who had previously been treated with sulindac, fenoprofen calcium, high dose salicylates and gold salts, developed renal papillar", "tokenized_content": [2, 15096, 12964, 14946, 5016, 3, 2019, 2642, 8884, 16, 2746, 2430, 3024, 2252, 2868, 1956, 9596, 2762, 1948, 16, 15096, 12964, 14946, 5016, 16, 2149, 3253, 20734, 9075, 1036, 1930, 3]}, "items": [{"id": "p_1460", "content": "Fenoprofen [SEP] An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to ASPIRIN, but ", "score": 1, "type": null, "tokenized_content": [2, 15096, 12964, 14946, 3, 1925, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 3626, 4124, 1942, 3582, 2697, 18, 2176, 1977, 24645, 2551, 1942, 12396, 16, 2308, 3]}]}
{"query": {"id": "q_1461", "content": "salicylates [SEP] ously been treated with sulindac, fenoprofen calcium, high dose salicylates and gold salts, developed renal papillary necrosis (RPN) 4 mont", "tokenized_content": [2, 20734, 9075, 1036, 3, 17208, 1036, 1954, 2252, 2868, 1956, 9596, 2762, 1948, 16, 15096, 12964, 14946, 5016, 16, 2149, 3253, 20734, 9075, 1036, 1930, 6557, 16028, 16, 3530, 4604, 3]}, "items": [{"id": "p_1461", "content": "Salicylates [SEP] The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and ", "score": 1, "type": null, "tokenized_content": [2, 20734, 9075, 1036, 3, 1920, 16028, 2014, 16785, 1927, 20734, 14523, 4576, 16, 2014, 20734, 9075, 16785, 1927, 1925, 6805, 2687, 18, 2673, 1927, 2144, 2162, 14501, 16, 2246, 18425, 3023, 16, 1930, 3]}]}
{"query": {"id": "q_1462", "content": "gold [SEP] ed with sulindac, fenoprofen calcium, high dose salicylates and gold salts, developed renal papillary necrosis (RPN) 4 months after ", "tokenized_content": [2, 6557, 3, 3347, 1956, 9596, 2762, 1948, 16, 15096, 12964, 14946, 5016, 16, 2149, 3253, 20734, 9075, 1036, 1930, 6557, 16028, 16, 3530, 4604, 15787, 7476, 12, 4822, 1022, 13, 3]}, "items": [{"id": "p_1462", "content": "Gold [SEP] A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating", "score": 1, "type": null, "tokenized_content": [2, 6557, 3, 43, 7463, 16790, 6149, 1956, 1920, 11241, 17530, 5759, 16, 11241, 2529, 5637, 16, 1930, 11241, 3388, 5876, 18, 2176, 1977, 2251, 1922, 28296, 1938, 6907, 16, 6557, 8516, 1029, 3]}]}
{"query": {"id": "q_1463", "content": "renal papillary necrosis [SEP] profen calcium, high dose salicylates and gold salts, developed renal papillary necrosis (RPN) 4 months after institution of naproxen therapy. No other ", "tokenized_content": [2, 4604, 15787, 7476, 3, 3150, 1917, 5016, 16, 2149, 3253, 20734, 9075, 1036, 1930, 6557, 16028, 16, 3530, 4604, 15787, 7476, 12, 4822, 1022, 13, 24, 3221, 2256, 5115, 1927, 3]}, "items": [{"id": "p_1463", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_1464", "content": "RPN [SEP] salicylates and gold salts, developed renal papillary necrosis (RPN) 4 months after institution of naproxen therapy. No other facto", "tokenized_content": [2, 4822, 1022, 3, 20734, 9075, 1036, 1930, 6557, 16028, 16, 3530, 4604, 15787, 7476, 12, 4822, 1022, 13, 24, 3221, 2256, 5115, 1927, 14290, 12222, 1917, 3181, 18, 2239, 2303, 3]}, "items": [{"id": "p_1464", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_1465", "content": "naproxen [SEP] ed renal papillary necrosis (RPN) 4 months after institution of naproxen therapy. No other factor predisposing to RPN could be discovere", "tokenized_content": [2, 14290, 12222, 1917, 3, 3347, 4604, 15787, 7476, 12, 4822, 1022, 13, 24, 3221, 2256, 5115, 1927, 14290, 12222, 1917, 3181, 18, 2239, 2303, 2991, 20908, 1942, 4822, 1022, 2578, 3]}, "items": [{"id": "p_1465", "content": "Naproxen [SEP] An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatmen", "score": 1, "type": null, "tokenized_content": [2, 14290, 12222, 1917, 3, 1925, 2246, 17, 3769, 5899, 1956, 14501, 1930, 2246, 18425, 3023, 3879, 18, 2321, 1920, 2687, 1930, 2496, 5227, 7012, 2032, 2251, 1922, 1920, 2297, 19047, 3]}]}
{"query": {"id": "q_1466", "content": "Sulindac [SEP] erapy. No other factor predisposing to RPN could be discovered. Sulindac was substituted for naproxen and no further adverse renal effec", "tokenized_content": [2, 9596, 2762, 1948, 3, 14821, 13976, 18, 2239, 2303, 2991, 20908, 1942, 4822, 1022, 2578, 1998, 8117, 18, 9596, 2762, 1948, 1982, 11798, 1958, 14290, 12222, 1917, 1930, 2239, 2520, 3]}, "items": [{"id": "p_1466", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_1467", "content": "renal toxicity [SEP] ossible advantages of sulindac in patients who have experienced renal toxicity from other antiinflammatory agents.", "tokenized_content": [2, 4604, 5532, 3, 16420, 2563, 8518, 1927, 9596, 2762, 1948, 1922, 2132, 2746, 2162, 6090, 4604, 5532, 2037, 2303, 2246, 9899, 4820, 18, 3]}, "items": [{"id": "p_1467", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1468", "content": "beta-adrenergic blocking drugs [SEP] Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases.", "tokenized_content": [2, 4666, 17, 13672, 7472, 4195, 3, 5246, 2835, 2192, 4666, 17, 13672, 7472, 4195, 1930, 23300, 17, 17, 3809, 1927, 2559, 2919, 18, 3]}, "items": [{"id": "p_1468", "content": "Adrenergic beta-Antagonists [SEP] Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adren", "score": 1, "type": null, "tokenized_content": [2, 13672, 4666, 17, 10515, 3, 4195, 1988, 4566, 1942, 2308, 2608, 2084, 6980, 4666, 17, 13672, 4086, 6113, 7472, 1920, 7728, 1927, 4666, 17, 13672, 9849, 18, 7206, 3]}]}
{"query": {"id": "q_1469", "content": "verapamil [SEP] Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases.", "tokenized_content": [2, 23300, 3, 5246, 2835, 2192, 4666, 17, 13672, 7472, 4195, 1930, 23300, 17, 17, 3809, 1927, 2559, 2919, 18, 3]}, "items": [{"id": "p_1469", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_1470", "content": "ischaemic heart disease [SEP] Three patients with ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia", "tokenized_content": [2, 19855, 4003, 2573, 3, 2559, 2132, 1956, 19855, 4003, 2573, 3530, 11098, 4435, 4574, 16, 16453, 1930, 26192, 3]}, "items": [{"id": "p_1470", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_1471", "content": "cardiac failure [SEP] Three patients with ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verap", "tokenized_content": [2, 4435, 4574, 3, 2559, 2132, 1956, 19855, 4003, 2573, 3530, 11098, 4435, 4574, 16, 16453, 1930, 26192, 2409, 4252, 3181, 1956, 3566, 2026, 3]}, "items": [{"id": "p_1471", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1472", "content": "hypotension [SEP] ith ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and beta", "tokenized_content": [2, 16453, 3, 24737, 19855, 4003, 2573, 3530, 11098, 4435, 4574, 16, 16453, 1930, 26192, 2409, 4252, 3181, 1956, 23300, 1930, 4666, 3]}, "items": [{"id": "p_1472", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1473", "content": "bradycardia [SEP] art disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic bloc", "tokenized_content": [2, 26192, 3, 6903, 2573, 3530, 11098, 4435, 4574, 16, 16453, 1930, 26192, 2409, 4252, 3181, 1956, 23300, 1930, 4666, 17, 13672, 30445, 3]}, "items": [{"id": "p_1473", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1474", "content": "verapamil [SEP] ilure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs. This clinical picture resol", "tokenized_content": [2, 23300, 3, 2614, 2027, 16, 16453, 1930, 26192, 2409, 4252, 3181, 1956, 23300, 1930, 4666, 17, 13672, 7472, 4195, 18, 2052, 2535, 10213, 24321, 3]}, "items": [{"id": "p_1474", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_1475", "content": "beta-adrenergic blocking drugs [SEP] sion and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs. This clinical picture resolved completely with cessation of th", "tokenized_content": [2, 4666, 17, 13672, 7472, 4195, 3, 5998, 1916, 1930, 26192, 2409, 4252, 3181, 1956, 23300, 1930, 4666, 17, 13672, 7472, 4195, 18, 2052, 2535, 10213, 8397, 5796, 1956, 10975, 1927, 3]}, "items": [{"id": "p_1475", "content": "Adrenergic beta-Antagonists [SEP] Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adren", "score": 1, "type": null, "tokenized_content": [2, 13672, 4666, 17, 10515, 3, 4195, 1988, 4566, 1942, 2308, 2608, 2084, 6980, 4666, 17, 13672, 4086, 6113, 7472, 1920, 7728, 1927, 4666, 17, 13672, 9849, 18, 7206, 3]}]}
{"query": {"id": "q_1476", "content": "bendrofluazide [SEP] Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report ", "tokenized_content": [2, 20672, 28716, 5277, 29895, 3, 5246, 5298, 1942, 20672, 28716, 5277, 29895, 1930, 21395, 1958, 1920, 2311, 1927, 5809, 5579, 18, 3809, 3]}, "items": [{"id": "p_1476", "content": "Bendroflumethiazide [SEP] A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial", "score": 1, "type": null, "tokenized_content": [2, 20672, 28716, 5277, 23568, 7736, 2261, 3, 43, 27225, 2261, 26829, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 14369, 30354, 2261, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 11444, 3]}]}
{"query": {"id": "q_1477", "content": "propranolol [SEP] Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Resea", "tokenized_content": [2, 21395, 3, 5246, 5298, 1942, 20672, 28716, 5277, 29895, 1930, 21395, 1958, 1920, 2311, 1927, 5809, 5579, 18, 3809, 1927, 3423, 1995, 5376, 3]}, "items": [{"id": "p_1477", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_1478", "content": "hypertension [SEP] ons to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Research Council Working Party on Mild to Mo", "tokenized_content": [2, 5579, 3, 24335, 1942, 20672, 28716, 5277, 29895, 1930, 21395, 1958, 1920, 2311, 1927, 5809, 5579, 18, 3809, 1927, 3423, 2659, 11198, 5905, 20700, 1990, 5809, 1942, 2661, 3]}, "items": [{"id": "p_1478", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1479", "content": "Hypertension [SEP] t of Medical Research Council Working Party on Mild to Moderate Hypertension.", "tokenized_content": [2, 5579, 3, 62, 1927, 3423, 2659, 11198, 5905, 20700, 1990, 5809, 1942, 5086, 5579, 18, 3]}, "items": [{"id": "p_1479", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1480", "content": "hypertension [SEP] ipants in the Medical Research Council treatment trial for mild hypertension are randomly allocated to one of four treatment groups: bendrof", "tokenized_content": [2, 5579, 3, 16736, 4905, 1036, 1922, 1920, 3423, 2659, 11198, 2311, 3046, 1958, 5809, 5579, 2032, 6266, 14553, 1942, 2340, 1927, 3006, 2311, 2671, 30, 20672, 28716, 3]}, "items": [{"id": "p_1480", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1481", "content": "bendrofluazide [SEP] tension are randomly allocated to one of four treatment groups: bendrofluazide, propranolol, or a placebo for either of these drugs. The trial", "tokenized_content": [2, 20672, 28716, 5277, 29895, 3, 10146, 2032, 6266, 14553, 1942, 2340, 1927, 3006, 2311, 2671, 30, 20672, 28716, 5277, 29895, 16, 21395, 16, 2014, 43, 5936, 1958, 3108, 1927, 2144, 3]}, "items": [{"id": "p_1481", "content": "Bendroflumethiazide [SEP] A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial", "score": 1, "type": null, "tokenized_content": [2, 20672, 28716, 5277, 23568, 7736, 2261, 3, 43, 27225, 2261, 26829, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 14369, 30354, 2261, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 11444, 3]}]}
{"query": {"id": "q_1482", "content": "propranolol [SEP] omly allocated to one of four treatment groups: bendrofluazide, propranolol, or a placebo for either of these drugs. The trial is single-bl", "tokenized_content": [2, 21395, 3, 7254, 1954, 14553, 1942, 2340, 1927, 3006, 2311, 2671, 30, 20672, 28716, 5277, 29895, 16, 21395, 16, 2014, 43, 5936, 1958, 3108, 1927, 2144, 4195, 18, 1920, 3046, 3]}, "items": [{"id": "p_1482", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_1483", "content": "impotence [SEP] esults show an association between bendrofluazide treatment and impotence, and impotence also occurred more frequently in patients taking", "tokenized_content": [2, 2754, 7229, 15895, 1021, 3, 2376, 17620, 2146, 1925, 3279, 2192, 20672, 28716, 5277, 29895, 2311, 1930, 2754, 7229, 15895, 1021, 16, 1930, 2754, 7229, 15895, 1021, 2222, 4807, 2253, 3]}, "items": [{"id": "p_1483", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_1484", "content": "impaired glucose tolerance [SEP] dverse reactions significantly linked with active drugs include impaired glucose tolerance in men and women and gout in men, associated with bendrofluazid", "tokenized_content": [2, 5761, 3817, 6555, 3, 11203, 2045, 1021, 5298, 2567, 4624, 1956, 3500, 4195, 3951, 5761, 3817, 6555, 1922, 3925, 1930, 3089, 1930, 22952, 1922, 3925, 16, 2458, 1956, 20672, 28716, 3]}, "items": [{"id": "p_1484", "content": "Glucose Intolerance [SEP] A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above appro", "score": 1, "type": null, "tokenized_content": [2, 3817, 19202, 3, 43, 6598, 3360, 1922, 2154, 2877, 3817, 2237, 1977, 2941, 2254, 3993, 8949, 2786, 19, 2813, 2646, 1927, 3582, 2019, 8712, 16, 1930, 3538, 2440, 3]}]}
{"query": {"id": "q_1485", "content": "gout [SEP] e drugs include impaired glucose tolerance in men and women and gout in men, associated with bendrofluazide treatment, and Raynaud's", "tokenized_content": [2, 22952, 3, 47, 4195, 3951, 5761, 3817, 6555, 1922, 3925, 1930, 3089, 1930, 22952, 1922, 3925, 16, 2458, 1956, 20672, 28716, 5277, 29895, 2311, 16, 1930, 6451, 2175, 2009, 11, 3]}, "items": [{"id": "p_1485", "content": "Gout [SEP] Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and ar", "score": 1, "type": null, "tokenized_content": [2, 22952, 3, 16321, 4487, 4770, 4378, 2007, 7457, 3939, 8884, 16, 4194, 15861, 3847, 1930, 7860, 1927, 5227, 3674, 2010, 1922, 1930, 2245, 3]}]}
{"query": {"id": "q_1486", "content": "Raynaud's phenomenon [SEP]  and gout in men, associated with bendrofluazide treatment, and Raynaud's phenomenon and dyspnoea in men and women taking propranolol. No corneal di", "tokenized_content": [2, 6451, 2175, 2009, 11, 61, 7902, 3, 1930, 22952, 1922, 3925, 16, 2458, 1956, 20672, 28716, 5277, 29895, 2311, 16, 1930, 6451, 2175, 2009, 11, 61, 7902, 1930, 14633, 26447, 3]}, "items": [{"id": "p_1486", "content": "Raynaud Disease [SEP] An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS ", "score": 1, "type": null, "tokenized_content": [2, 6451, 2175, 2009, 2573, 3, 1925, 13513, 4541, 4770, 4378, 2007, 7787, 6451, 2175, 2009, 7902, 16, 1920, 20135, 4727, 1927, 8225, 16222, 2971, 2014, 26898, 8362, 3]}]}
{"query": {"id": "q_1487", "content": "dyspnoea [SEP] ted with bendrofluazide treatment, and Raynaud's phenomenon and dyspnoea in men and women taking propranolol. No corneal disease is know", "tokenized_content": [2, 14633, 26447, 3, 26080, 1956, 20672, 28716, 5277, 29895, 2311, 16, 1930, 6451, 2175, 2009, 11, 61, 7902, 1930, 14633, 26447, 1922, 3925, 1930, 3089, 6303, 21395, 18, 2239, 9990, 3]}, "items": [{"id": "p_1487", "content": "Dyspnea [SEP] Difficult or labored breathing.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18461, 3, 4571, 2014, 3876, 1919, 11995, 18, 3]}]}
{"query": {"id": "q_1488", "content": "corneal disease [SEP] phenomenon and dyspnoea in men and women taking propranolol. No corneal disease is known to have occurred in the propranolol group. Mean serum ", "tokenized_content": [2, 9990, 2573, 3, 7902, 1930, 14633, 26447, 1922, 3925, 1930, 3089, 6303, 21395, 18, 2239, 9990, 2573, 1977, 3171, 1942, 2162, 4807, 1922, 1920, 21395, 2210, 18, 2667, 3256, 3]}, "items": [{"id": "p_1488", "content": "Corneal Diseases [SEP] Diseases of the cornea.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9990, 3902, 3, 3902, 1927, 1920, 16678, 18, 3]}]}
{"query": {"id": "q_1489", "content": "potassium [SEP]  is known to have occurred in the propranolol group. Mean serum potassium level fell, and urea and uric acid levels rose, in men and wome", "tokenized_content": [2, 9057, 3, 1977, 3171, 1942, 2162, 4807, 1922, 1920, 21395, 2210, 18, 2667, 3256, 9057, 2237, 9650, 16, 1930, 10505, 1930, 17607, 2687, 2428, 13679, 16, 1922, 3925, 1930, 26334, 3]}, "items": [{"id": "p_1489", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1490", "content": "urea [SEP]  in the propranolol group. Mean serum potassium level fell, and urea and uric acid levels rose, in men and women taking bendrofluazi", "tokenized_content": [2, 10505, 3, 1922, 1920, 21395, 2210, 18, 2667, 3256, 9057, 2237, 9650, 16, 1930, 10505, 1930, 17607, 2687, 2428, 13679, 16, 1922, 3925, 1930, 3089, 6303, 20672, 28716, 5277, 3408, 3]}, "items": [{"id": "p_1490", "content": "Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote", "score": 1, "type": null, "tokenized_content": [2, 10505, 3, 43, 3547, 5333, 1922, 1920, 3568, 2037, 14880, 4152, 2007, 1920, 30097, 8547, 1943, 1927, 3835, 4576, 18, 2176, 1977, 1920, 7944, 2482, 4863, 1927, 2174, 3]}]}
{"query": {"id": "q_1491", "content": "uric acid [SEP] ropranolol group. Mean serum potassium level fell, and urea and uric acid levels rose, in men and women taking bendrofluazide. In the pro", "tokenized_content": [2, 17607, 2687, 3, 17890, 17182, 23646, 2210, 18, 2667, 3256, 9057, 2237, 9650, 16, 1930, 10505, 1930, 17607, 2687, 2428, 13679, 16, 1922, 3925, 1930, 3089, 6303, 20672, 28716, 5277, 3]}, "items": [{"id": "p_1491", "content": "Uric Acid [SEP] An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product o", "score": 1, "type": null, "tokenized_content": [2, 17607, 2687, 3, 1925, 6638, 4863, 16, 3454, 26059, 10488, 16, 1927, 20004, 1034, 17687, 1036, 2427, 1966, 26059, 1930, 5918, 24943, 18, 2176, 1977, 1920, 3948, 6638, 4863, 57, 3]}]}
{"query": {"id": "q_1492", "content": "Dexmedetomidine [SEP] Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis", "tokenized_content": [2, 26854, 3, 26854, 1930, 4435, 6202, 1958, 2447, 17, 4435, 3782, 30, 43, 5880, 17, 2333, 3]}, "items": [{"id": "p_1492", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_1493", "content": "dexmedetomidine [SEP] We conducted a systematic review of the effects of dexmedetomidine on cardiac outcomes following non-cardiac surgery. We included ", "tokenized_content": [2, 26854, 3, 2038, 3609, 43, 5614, 3043, 1927, 1920, 2564, 1927, 26854, 1990, 4435, 3685, 2894, 2447, 17, 4435, 3782, 18, 2038, 3063, 3]}, "items": [{"id": "p_1493", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_1494", "content": "Dexmedetomidine [SEP] entified, 20 were included in the meta-analysis (840 patients). Dexmedetomidine was associated with a trend towards improved cardiac outcomes; ", "tokenized_content": [2, 26854, 3, 5080, 27983, 16, 2036, 1985, 3063, 1922, 1920, 5880, 17, 2333, 12, 5686, 1008, 2132, 13, 18, 26854, 1982, 2458, 1956, 43, 5045, 5681, 4305, 4435, 3685, 31, 3]}, "items": [{"id": "p_1494", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_1495", "content": "myocardial infarction [SEP] ause mortality (OR 0.27, 95% CI 0.01-7.13, p = 0.44), non-fatal myocardial infarction (OR 0.26, 95% CI 0.04-1.60, p = 0.14), and myocardial ischaemia", "tokenized_content": [2, 6497, 8358, 3, 18238, 1021, 3885, 12, 2014, 20, 18, 3225, 16, 3002, 9, 3371, 20, 18, 3287, 17, 27, 18, 2590, 16, 58, 33, 20, 18, 4044, 13, 16, 3]}, "items": [{"id": "p_1495", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1496", "content": "myocardial ischaemia [SEP] yocardial infarction (OR 0.26, 95% CI 0.04-1.60, p = 0.14), and myocardial ischaemia (OR 0.65, 95% CI 0.26-1.63, p = 0.36). Peri-operative hypotensi", "tokenized_content": [2, 6497, 22927, 3, 7419, 15339, 7408, 1923, 8358, 12, 2014, 20, 18, 3179, 16, 3002, 9, 3371, 20, 18, 5228, 17, 21, 18, 3276, 16, 58, 33, 20, 18, 2607, 3]}, "items": [{"id": "p_1496", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_1497", "content": "hypotension [SEP] ischaemia (OR 0.65, 95% CI 0.26-1.63, p = 0.36). Peri-operative hypotension (26%, OR 3.80, 95% CI 1.91-7.54, p = 0.0001) and bradycardia (1", "tokenized_content": [2, 16453, 3, 22927, 12, 2014, 20, 18, 4459, 16, 3002, 9, 3371, 20, 18, 3179, 17, 21, 18, 4968, 16, 58, 33, 20, 18, 3480, 13, 18, 2953, 17, 8116, 3]}, "items": [{"id": "p_1497", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1498", "content": "bradycardia [SEP] ve hypotension (26%, OR 3.80, 95% CI 1.91-7.54, p = 0.0001) and bradycardia (17%, OR 5.45, 95% CI 2.98-9.95, p < 0.00001) were significantl", "tokenized_content": [2, 26192, 3, 3428, 16453, 12, 3179, 9, 16, 2014, 23, 18, 3729, 16, 3002, 9, 3371, 21, 18, 6550, 17, 27, 18, 4584, 16, 58, 33, 20, 18, 6060, 13, 3]}, "items": [{"id": "p_1498", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1499", "content": "creatine [SEP] Differential diagnosis of high serum creatine kinase levels in systemic lupus erythematosus.", "tokenized_content": [2, 17784, 3, 5611, 3574, 1927, 2149, 3256, 17784, 4016, 2428, 1922, 5510, 13711, 22045, 18, 3]}, "items": [{"id": "p_1499", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_1500", "content": "systemic lupus erythematosus [SEP] Differential diagnosis of high serum creatine kinase levels in systemic lupus erythematosus.", "tokenized_content": [2, 5510, 13711, 22045, 3, 5611, 3574, 1927, 2149, 3256, 17784, 4016, 2428, 1922, 5510, 13711, 22045, 18, 3]}, "items": [{"id": "p_1500", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_1501", "content": "chloroquine [SEP] inical and bioptic findings for a 57-year-old woman with severe chloroquine-induced myopathy. Since 1989, she had been suffering from syste", "tokenized_content": [2, 20813, 3, 1922, 2046, 1930, 20864, 2002, 3056, 1958, 43, 4786, 17, 2476, 17, 4156, 10440, 1956, 4010, 20813, 17, 2719, 25017, 18, 3328, 9982, 16, 4693, 2430, 2252, 11364, 3]}, "items": [{"id": "p_1501", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_1502", "content": "myopathy [SEP] indings for a 57-year-old woman with severe chloroquine-induced myopathy. Since 1989, she had been suffering from systemic lupus erythem", "tokenized_content": [2, 25017, 3, 2063, 4689, 1958, 43, 4786, 17, 2476, 17, 4156, 10440, 1956, 4010, 20813, 17, 2719, 25017, 18, 3328, 9982, 16, 4693, 2430, 2252, 11364, 2037, 5510, 13711, 6549, 3]}, "items": [{"id": "p_1502", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1503", "content": "systemic lupus erythematosus [SEP] quine-induced myopathy. Since 1989, she had been suffering from systemic lupus erythematosus (SLE) with renal involvement and undergone periods of treatment", "tokenized_content": [2, 5510, 13711, 22045, 3, 9012, 1021, 17, 2719, 25017, 18, 3328, 9982, 16, 4693, 2430, 2252, 11364, 2037, 5510, 13711, 22045, 12, 4565, 13, 1956, 4604, 5668, 1930, 12299, 6696, 3]}, "items": [{"id": "p_1503", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_1504", "content": "SLE [SEP] 1989, she had been suffering from systemic lupus erythematosus (SLE) with renal involvement and undergone periods of treatment with", "tokenized_content": [2, 4565, 3, 9982, 16, 4693, 2430, 2252, 11364, 2037, 5510, 13711, 22045, 12, 4565, 13, 1956, 4604, 5668, 1930, 12299, 6696, 1927, 2311, 1956, 3]}, "items": [{"id": "p_1504", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_1505", "content": "renal involvement [SEP] had been suffering from systemic lupus erythematosus (SLE) with renal involvement and undergone periods of treatment with azathioprine and cyclop", "tokenized_content": [2, 4604, 5668, 3, 2430, 2252, 11364, 2037, 5510, 13711, 22045, 12, 4565, 13, 1956, 4604, 5668, 1930, 12299, 6696, 1927, 2311, 1956, 30499, 5773, 1930, 20585, 3]}, "items": [{"id": "p_1505", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1506", "content": "azathioprine [SEP]  with renal involvement and undergone periods of treatment with azathioprine and cyclophosphamide. Additional therapy with chloroquine (CQ) ", "tokenized_content": [2, 30499, 5773, 3, 1956, 4604, 5668, 1930, 12299, 6696, 1927, 2311, 1956, 30499, 5773, 1930, 17135, 18, 3281, 3181, 1956, 20813, 12, 15705, 13, 3]}, "items": [{"id": "p_1506", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_1507", "content": "cyclophosphamide [SEP] vement and undergone periods of treatment with azathioprine and cyclophosphamide. Additional therapy with chloroquine (CQ) was started because o", "tokenized_content": [2, 17135, 3, 27706, 1939, 1930, 12299, 6696, 1927, 2311, 1956, 30499, 5773, 1930, 17135, 18, 3281, 3181, 1956, 20813, 12, 15705, 13, 1982, 8074, 2882, 57, 3]}, "items": [{"id": "p_1507", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_1508", "content": "CQ [SEP] rine and cyclophosphamide. Additional therapy with chloroquine (CQ) was started because of arthralgia. At the same time, slightly ", "tokenized_content": [2, 15705, 3, 25699, 1021, 1930, 17135, 18, 3281, 3181, 1956, 20813, 12, 15705, 13, 1982, 8074, 2882, 1927, 9273, 7317, 11966, 18, 2019, 1920, 2841, 2367, 16, 5733, 3]}, "items": [{"id": "p_1508", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_1509", "content": "arthralgia [SEP] Additional therapy with chloroquine (CQ) was started because of arthralgia. At the same time, slightly increased creatine kinase (CK) leve", "tokenized_content": [2, 9273, 7317, 11966, 3, 3281, 3181, 1956, 20813, 12, 15705, 13, 1982, 8074, 2882, 1927, 9273, 7317, 11966, 18, 2019, 1920, 2841, 2367, 16, 5733, 2502, 17784, 4016, 12, 6394, 3]}, "items": [{"id": "p_1509", "content": "Arthralgia [SEP] Pain in the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 7317, 11966, 3, 3594, 1922, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_1510", "content": "creatine [SEP] ted because of arthralgia. At the same time, slightly increased creatine kinase (CK) levels were noted. Myositis was suspected, and the ", "tokenized_content": [2, 17784, 3, 26080, 2882, 1927, 9273, 7317, 11966, 18, 2019, 1920, 2841, 2367, 16, 5733, 2502, 17784, 4016, 12, 6394, 13, 2428, 1985, 5040, 18, 15924, 12924, 3600, 1982, 9407, 3]}, "items": [{"id": "p_1510", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_1511", "content": "Myositis [SEP] ime, slightly increased creatine kinase (CK) levels were noted. Myositis was suspected, and the patient was treated with steroids. The C", "tokenized_content": [2, 15924, 12924, 3600, 3, 2042, 1021, 16, 5733, 2502, 17784, 4016, 12, 6394, 13, 2428, 1985, 5040, 18, 15924, 12924, 3600, 1982, 9407, 16, 1930, 1920, 2774, 1982, 2868, 1956, 3]}, "items": [{"id": "p_1511", "content": "Myositis [SEP] Inflammation of a muscle or muscle tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15924, 12924, 3600, 3, 4531, 1927, 43, 3760, 2014, 3760, 2960, 18, 3]}]}
{"query": {"id": "q_1512", "content": "steroids [SEP] noted. Myositis was suspected, and the patient was treated with steroids. The CK increase persisted, however, and she developed progress", "tokenized_content": [2, 13039, 3, 5040, 18, 15924, 12924, 3600, 1982, 9407, 16, 1930, 1920, 2774, 1982, 2868, 1956, 13039, 18, 1920, 6394, 2760, 14583, 16, 2406, 16, 1930, 4693, 3530, 4782, 3]}, "items": [{"id": "p_1512", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_1513", "content": "muscular weakness [SEP] e CK increase persisted, however, and she developed progressive muscular weakness and muscular atrophy. Routine controls revealed markedly elevat", "tokenized_content": [2, 12330, 12175, 3, 47, 6394, 2760, 14583, 16, 2406, 16, 1930, 4693, 3530, 7529, 12330, 12175, 1930, 12330, 10260, 18, 7341, 3562, 3404, 7686, 3946, 1926, 3]}, "items": [{"id": "p_1513", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_1514", "content": "muscular atrophy [SEP] d, however, and she developed progressive muscular weakness and muscular atrophy. Routine controls revealed markedly elevated CK levels of 1,700", "tokenized_content": [2, 12330, 10260, 3, 46, 16, 2406, 16, 1930, 4693, 3530, 7529, 12330, 12175, 1930, 12330, 10260, 18, 7341, 3562, 3404, 7686, 4664, 6394, 2428, 1927, 21, 16, 11851, 3]}, "items": [{"id": "p_1514", "content": "Muscular Atrophy [SEP] Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, pr", "score": 1, "type": null, "tokenized_content": [2, 12330, 10260, 3, 3135, 9538, 1922, 3081, 1930, 2529, 1927, 3760, 6989, 6966, 1956, 6619, 16, 3378, 1922, 2877, 9042, 16, 2014, 2894, 16704, 16, 2033, 3]}]}
{"query": {"id": "q_1515", "content": "myositis [SEP] rological and electrophysiological findings were not typical of myositis. Thus, muscle biopsy of the deltoid muscle was performed in ord", "tokenized_content": [2, 15924, 12924, 3600, 3, 29144, 2021, 2046, 1930, 13189, 3056, 1985, 2084, 5939, 1927, 15924, 12924, 3600, 18, 2842, 16, 3760, 6831, 1927, 1920, 17496, 2642, 3760, 1982, 2593, 1922, 3]}, "items": [{"id": "p_1515", "content": "Myositis [SEP] Inflammation of a muscle or muscle tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15924, 12924, 3600, 3, 4531, 1927, 43, 3760, 2014, 3760, 2960, 18, 3]}]}
{"query": {"id": "q_1516", "content": "polymyositis [SEP]  biopsy of the deltoid muscle was performed in order to exclude polymyositis or toxic myopathy. As it revealed chloroquine-induced myopathy,", "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 6831, 1927, 1920, 17496, 2642, 3760, 1982, 2593, 1922, 3238, 1942, 10443, 3491, 25749, 12924, 3600, 2014, 6161, 25017, 18, 1966, 2176, 3404, 20813, 17, 3]}, "items": [{"id": "p_1516", "content": "Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi", "score": 1, "type": null, "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3902, 4378, 2007, 4531, 5884, 3137, 7848, 18, 2052, 2278, 4704, 1966, 1925, 3939, 2014, 3724, 2625, 2458, 11980, 3]}]}
{"query": {"id": "q_1517", "content": "affection of the musculoskeletal system [SEP] ication was stopped. Discriminating between primary SLE-induced affection of the musculoskeletal system and drug-induced side effects is important for appropriate trea", "tokenized_content": [2, 4081, 2001, 1927, 1920, 15322, 2433, 3, 14784, 1929, 1982, 12032, 18, 20287, 2192, 3065, 4565, 17, 2719, 4081, 2001, 1927, 1920, 15322, 2433, 1930, 2838, 17, 2719, 4159, 2564, 3]}, "items": [{"id": "p_1517", "content": "Musculoskeletal Diseases [SEP] Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collect", "score": 1, "type": null, "tokenized_content": [2, 15322, 3902, 3, 3902, 1927, 1920, 7848, 1930, 2310, 2458, 27831, 1930, 2303, 14948, 2960, 1930, 1927, 1920, 14153, 1930, 8642, 11103, 11946, 3]}]}
{"query": {"id": "q_1518", "content": "ribavirin [SEP] Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised ch", "tokenized_content": [2, 23635, 3, 7307, 23635, 2311, 1958, 4010, 13354, 2573, 1922, 21134, 2016, 3]}, "items": [{"id": "p_1518", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1519", "content": "adenovirus disease [SEP] Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children.", "tokenized_content": [2, 13354, 2573, 3, 7307, 23635, 2311, 1958, 4010, 13354, 2573, 1922, 21134, 3069, 18, 3]}, "items": [{"id": "p_1519", "content": "Adenoviridae Infections [SEP] Virus diseases caused by the ADENOVIRIDAE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29639, 3026, 10828, 5024, 3, 3413, 3902, 4189, 2007, 1920, 29639, 3026, 10828, 18, 3]}]}
{"query": {"id": "q_1520", "content": "adenovirus disease [SEP] ortality in the immunocompromised host. The incidence of severe adenovirus disease in pediatrics is increasing in association with growing numbers", "tokenized_content": [2, 13354, 2573, 3, 2014, 2381, 1999, 1922, 1920, 21134, 4423, 18, 1920, 4332, 1927, 4010, 13354, 2573, 1922, 22786, 1977, 3605, 1922, 3279, 1956, 6552, 4630, 3]}, "items": [{"id": "p_1520", "content": "Adenoviridae Infections [SEP] Virus diseases caused by the ADENOVIRIDAE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29639, 3026, 10828, 5024, 3, 3413, 3902, 4189, 2007, 1920, 29639, 3026, 10828, 18, 3]}]}
{"query": {"id": "q_1521", "content": "ribavirin [SEP] ports and small series. Experience is greatest with intravenous ribavirin and cidofovir. Ribavirin, a guanosine analogue, has broad antiv", "tokenized_content": [2, 23635, 3, 9260, 1036, 1930, 2858, 4696, 18, 4848, 1977, 9449, 1956, 7307, 23635, 1930, 18069, 26489, 18, 23635, 16, 43, 24870, 12980, 16, 2258, 4949, 9539, 3]}, "items": [{"id": "p_1521", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1522", "content": "cidofovir [SEP] l series. Experience is greatest with intravenous ribavirin and cidofovir. Ribavirin, a guanosine analogue, has broad antiviral activity ", "tokenized_content": [2, 18069, 26489, 3, 54, 4696, 18, 4848, 1977, 9449, 1956, 7307, 23635, 1930, 18069, 26489, 18, 23635, 16, 43, 24870, 12980, 16, 2258, 4949, 10129, 2455, 3]}, "items": [{"id": "p_1522", "content": "cidofovir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18069, 26489, 3, 3]}]}
{"query": {"id": "q_1523", "content": "Ribavirin [SEP] xperience is greatest with intravenous ribavirin and cidofovir. Ribavirin, a guanosine analogue, has broad antiviral activity against bot", "tokenized_content": [2, 23635, 3, 15930, 18842, 2055, 1977, 9449, 1956, 7307, 23635, 1930, 18069, 26489, 18, 23635, 16, 43, 24870, 12980, 16, 2258, 4949, 10129, 2455, 3316, 12499, 3]}, "items": [{"id": "p_1523", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1524", "content": "guanosine [SEP] greatest with intravenous ribavirin and cidofovir. Ribavirin, a guanosine analogue, has broad antiviral activity against both RNA and DNA", "tokenized_content": [2, 24870, 3, 9449, 1956, 7307, 23635, 1930, 18069, 26489, 18, 23635, 16, 43, 24870, 12980, 16, 2258, 4949, 10129, 2455, 3316, 2321, 3146, 1930, 2678, 3]}, "items": [{"id": "p_1524", "content": "Guanosine [SEP] A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid", "score": 1, "type": null, "tokenized_content": [2, 24870, 3, 43, 19700, 18015, 1988, 2258, 16904, 4624, 2007, 2496, 56, 1026, 6634, 1942, 1920, 8817, 5056, 1927, 17870, 18, 2176, 1977, 43, 4594, 1927, 18347, 1935, 2687, 3]}]}
{"query": {"id": "q_1525", "content": "respiratory syncytial virus infection [SEP] tro. Ribavirin is licensed in aerosol form for the treatment of respiratory syncytial virus infection, and orally in combination with interferon to treat hepatitis C", "tokenized_content": [2, 5481, 29988, 3413, 2909, 3, 12730, 18, 23635, 1977, 20969, 1922, 16518, 2386, 1958, 1920, 2311, 1927, 5481, 29988, 3413, 2909, 16, 1930, 12950, 1922, 3921, 1956, 10001, 1942, 2297, 3]}, "items": [{"id": "p_1525", "content": "Respiratory Syncytial Virus Infections [SEP] Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats ", "score": 1, "type": null, "tokenized_content": [2, 5481, 29988, 3413, 5024, 3, 6097, 7414, 5024, 4189, 2007, 1920, 5481, 29988, 6241, 18, 5209, 1930, 11735, 2032, 2501, 4218, 2308, 5024, 1922, 21516, 3]}]}
{"query": {"id": "q_1526", "content": "hepatitis C [SEP] s infection, and orally in combination with interferon to treat hepatitis C. Intravenous ribavirin is the treatment of choice for infection", "tokenized_content": [2, 7977, 45, 3, 61, 2909, 16, 1930, 12950, 1922, 3921, 1956, 10001, 1942, 2297, 7977, 45, 18, 7307, 23635, 1977, 1920, 2311, 1927, 6259, 1958, 2909, 3]}, "items": [{"id": "p_1526", "content": "Hepatitis C [SEP] INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 day", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 7977, 45, 3413, 16, 43, 2957, 17, 10338, 3146, 3413, 18, 2496, 5282, 3047, 1977, 2627, 17, 3865, 3007, 3]}]}
{"query": {"id": "q_1527", "content": "infection with hemorrhagic fever viruses [SEP] patitis C. Intravenous ribavirin is the treatment of choice for infection with hemorrhagic fever viruses. The most common adverse effect of intravenous ribavirin is rev", "tokenized_content": [2, 2909, 1956, 16052, 9087, 6241, 3, 2091, 3600, 45, 18, 7307, 23635, 1977, 1920, 2311, 1927, 6259, 1958, 2909, 1956, 16052, 9087, 6241, 18, 1920, 2501, 3059, 5246, 2495, 1927, 3]}, "items": [{"id": "p_1527", "content": "Hemorrhagic Fevers, Viral [SEP] A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability", "score": 1, "type": null, "tokenized_content": [2, 16052, 9087, 1036, 16, 4324, 3, 43, 2210, 1927, 4324, 3902, 1927, 6445, 10383, 2308, 4537, 3086, 2551, 2535, 3779, 31, 2502, 9623, 8828, 3]}]}
{"query": {"id": "q_1528", "content": "anemia [SEP] mmon adverse effect of intravenous ribavirin is reversible mild anemia. The use of cidofovir in severe adenovirus infection has been l", "tokenized_content": [2, 10679, 3, 2489, 1916, 5246, 2495, 1927, 7307, 23635, 1977, 10743, 5809, 10679, 18, 1920, 2485, 1927, 18069, 26489, 1922, 4010, 13354, 2909, 2258, 2252, 54, 3]}, "items": [{"id": "p_1528", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_1529", "content": "adenovirus infection [SEP] virin is reversible mild anemia. The use of cidofovir in severe adenovirus infection has been limited by adverse effects, the most significant of wh", "tokenized_content": [2, 13354, 2909, 3, 2787, 1921, 1977, 10743, 5809, 10679, 18, 1920, 2485, 1927, 18069, 26489, 1922, 4010, 13354, 2909, 2258, 2252, 3892, 2007, 5246, 2564, 16, 1920, 2501, 2228, 1927, 3]}, "items": [{"id": "p_1529", "content": "Adenoviridae Infections [SEP] Virus diseases caused by the ADENOVIRIDAE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29639, 3026, 10828, 5024, 3, 3413, 3902, 4189, 2007, 1920, 29639, 3026, 10828, 18, 3]}]}
{"query": {"id": "q_1530", "content": "nephrotoxicity [SEP] en limited by adverse effects, the most significant of which is nephrotoxicity. OBJECTIVE: We report our experience with intravenous ribavirin", "tokenized_content": [2, 27880, 3, 2066, 3892, 2007, 5246, 2564, 16, 1920, 2501, 2228, 1927, 2154, 1977, 27880, 18, 4470, 30, 2038, 3809, 2342, 4848, 1956, 7307, 23635, 3]}, "items": [{"id": "p_1530", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1531", "content": "hemorrhagic [SEP] avenous ribavirin is the treatment of choice for infection with hemorrhagic fever viruses. The most common adverse effect of intravenous ri", "tokenized_content": [2, 16052, 3, 16959, 2080, 23635, 1977, 1920, 2311, 1927, 6259, 1958, 2909, 1956, 16052, 9087, 6241, 18, 1920, 2501, 3059, 5246, 2495, 1927, 7307, 11280, 3]}, "items": [{"id": "p_1531", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1532", "content": "cystitis [SEP] enovirus disease. Two patients developed adenovirus hemorrhagic cystitis after cardiac and bone marrow transplants, respectively. The bo", "tokenized_content": [2, 9446, 3678, 3, 2066, 7414, 2573, 18, 2288, 2132, 3530, 13354, 16052, 9446, 3678, 2256, 4435, 1930, 3622, 6599, 19214, 16, 2763, 18, 1920, 4078, 3]}, "items": [{"id": "p_1532", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_1533", "content": "adenovirus [SEP] ortality in the immunocompromised host. The incidence of severe adenovirus disease in pediatrics is increasing in association with growing", "tokenized_content": [2, 13354, 3, 2014, 2381, 1999, 1922, 1920, 21134, 4423, 18, 1920, 4332, 1927, 4010, 13354, 2573, 1922, 22786, 1977, 3605, 1922, 3279, 1956, 6552, 3]}, "items": [{"id": "p_1533", "content": "Adenoviridae Infections [SEP] Virus diseases caused by the ADENOVIRIDAE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29639, 3026, 10828, 5024, 3, 3413, 3902, 4189, 2007, 1920, 29639, 3026, 10828, 18, 3]}]}
{"query": {"id": "q_1534", "content": "pneumonia [SEP] eminated disease. An additional 3 children developed adenovirus pneumonia; 2 were neonates, 1 of whom had partial DiGeorge syndrome. The ", "tokenized_content": [2, 7868, 3, 2391, 4597, 2573, 18, 1925, 3281, 23, 3069, 3530, 13354, 7868, 31, 22, 1985, 13250, 16, 21, 1927, 8566, 2430, 5740, 4325, 1021, 1924, 2106, 4741, 18, 1920, 3]}, "items": [{"id": "p_1534", "content": "Pneumonia, Viral [SEP] Inflammation of the lung parenchyma that is caused by a viral infection.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7868, 16, 4324, 3, 4531, 1927, 1920, 3614, 15214, 1988, 1977, 4189, 2007, 43, 4324, 2909, 18, 3]}]}
{"query": {"id": "q_1535", "content": "DiGeorge syndrome [SEP] ed adenovirus pneumonia; 2 were neonates, 1 of whom had partial DiGeorge syndrome. The remaining infant had recently undergone a cardiac transpla", "tokenized_content": [2, 4325, 1021, 1924, 2106, 4741, 3, 3347, 13354, 7868, 31, 22, 1985, 13250, 16, 21, 1927, 8566, 2430, 5740, 4325, 1021, 1924, 2106, 4741, 18, 1920, 5719, 8125, 2430, 3998, 3]}, "items": [{"id": "p_1535", "content": "DiGeorge Syndrome [SEP] Congenital syndrome characterized by a wide spectrum of characteristics including the absence of the THYMUS and PARATHYROID GLAN", "score": 1, "type": null, "tokenized_content": [2, 4325, 1021, 1924, 2106, 4741, 3, 9901, 4741, 4378, 2007, 43, 4743, 5648, 1927, 3779, 2710, 1920, 3905, 1927, 1920, 15004, 1930, 17152, 27494, 1022, 3]}]}
{"query": {"id": "q_1536", "content": "progressive renal failure [SEP] well tolerated. Use of cidofovir in 1 child was associated with progressive renal failure and neutropenia. DISCUSSION: Our series of patients is represen", "tokenized_content": [2, 7529, 4604, 4574, 3, 2486, 11117, 18, 2485, 1927, 18069, 26489, 1922, 21, 2748, 1982, 2458, 1956, 7529, 4604, 4574, 1930, 18005, 18, 7248, 30, 2342, 4696, 1927, 2132, 1977, 3]}, "items": [{"id": "p_1536", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1537", "content": "neutropenia [SEP] ir in 1 child was associated with progressive renal failure and neutropenia. DISCUSSION: Our series of patients is representative of the sp", "tokenized_content": [2, 18005, 3, 3166, 1922, 21, 2748, 1982, 2458, 1956, 7529, 4604, 4574, 1930, 18005, 18, 7248, 30, 2342, 4696, 1927, 2132, 1977, 5051, 1927, 1920, 2056, 3]}, "items": [{"id": "p_1537", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1538", "content": "immunodeficiency [SEP]  bone marrow transplant recipients, neonates, and children with immunodeficiency. Although intravenous ribavirin was not effective for all child", "tokenized_content": [2, 13141, 3, 3622, 6599, 5192, 9336, 16, 13250, 16, 1930, 3069, 1956, 13141, 18, 2876, 7307, 23635, 1982, 2084, 3655, 1958, 2136, 2748, 3]}, "items": [{"id": "p_1538", "content": "Immunologic Deficiency Syndromes [SEP] Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21049, 6179, 12688, 3, 12688, 1922, 2154, 2276, 1977, 43, 6179, 2014, 7374, 1922, 1920, 3531, 1927, 7611, 16, 3108, 3689, 2014, 16601, 18, 3]}]}
{"query": {"id": "q_1539", "content": "infection [SEP] n aerosol form for the treatment of respiratory syncytial virus infection, and orally in combination with interferon to treat hepatitis C", "tokenized_content": [2, 2909, 3, 56, 16518, 2386, 1958, 1920, 2311, 1927, 5481, 29988, 3413, 2909, 16, 1930, 12950, 1922, 3921, 1956, 10001, 1942, 2297, 7977, 45, 3]}, "items": [{"id": "p_1539", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_1540", "content": "Hepatotoxicity [SEP] Hepatotoxicity of amiodarone.", "tokenized_content": [2, 24126, 3, 24126, 1927, 15665, 25033, 2830, 1021, 18, 3]}, "items": [{"id": "p_1540", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1541", "content": "amiodarone [SEP] Hepatotoxicity of amiodarone.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 24126, 1927, 15665, 25033, 2830, 1021, 18, 3]}, "items": [{"id": "p_1541", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1542", "content": "Amiodarone [SEP] Amiodarone has proved very effective in the treatment of otherwise resista", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 15665, 25033, 2830, 1021, 2258, 9534, 3345, 3655, 1922, 1920, 2311, 1927, 7631, 3088, 1019, 3]}, "items": [{"id": "p_1542", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1543", "content": "tachyarrhythmias [SEP]  very effective in the treatment of otherwise resistant cardiac tachyarrhythmias. The use of amiodarone has, however, been limited due to its se", "tokenized_content": [2, 12762, 9771, 18858, 10245, 15519, 3, 3345, 3655, 1922, 1920, 2311, 1927, 7631, 4910, 4435, 12762, 9771, 18858, 10245, 15519, 18, 1920, 2485, 1927, 15665, 25033, 2830, 1021, 2258, 16, 3]}, "items": [{"id": "p_1543", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_1544", "content": "amiodarone [SEP] ent of otherwise resistant cardiac tachyarrhythmias. The use of amiodarone has, however, been limited due to its serious side-effects. A p", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 8496, 1927, 7631, 4910, 4435, 12762, 9771, 18858, 10245, 15519, 18, 1920, 2485, 1927, 15665, 25033, 2830, 1021, 2258, 16, 2406, 16, 2252, 3892, 2810, 3]}, "items": [{"id": "p_1544", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1545", "content": "cholestatic [SEP] r, been limited due to its serious side-effects. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a ", "tokenized_content": [2, 21211, 2479, 3, 60, 16, 2252, 3892, 2810, 1942, 2496, 7433, 4159, 17, 2564, 18, 43, 2774, 1956, 21211, 2479, 7977, 2810, 1942, 15665, 25033, 2830, 1021, 2311, 1977, 3549, 3]}, "items": [{"id": "p_1545", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_1546", "content": "hepatitis [SEP] ted due to its serious side-effects. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a review of ", "tokenized_content": [2, 7977, 3, 26080, 2810, 1942, 2496, 7433, 4159, 17, 2564, 18, 43, 2774, 1956, 21211, 2479, 7977, 2810, 1942, 15665, 25033, 2830, 1021, 2311, 1977, 3549, 4535, 1930, 43, 3043, 3]}, "items": [{"id": "p_1546", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1547", "content": "hepatotoxicity [SEP]  to amiodarone treatment is presented below and a review of the hepatotoxicity of amiodarone is given. It is concluded that solid evidence exi", "tokenized_content": [2, 24126, 3, 1942, 15665, 25033, 2830, 1021, 2311, 1977, 3549, 4535, 1930, 43, 3043, 1927, 1920, 24126, 1927, 15665, 25033, 2830, 1021, 1977, 3258, 18, 2176, 1977, 7903, 1988, 5358, 3]}, "items": [{"id": "p_1547", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1548", "content": "hepatic injury [SEP] odarone is given. It is concluded that solid evidence exists of hepatic injury due to amiodarone treatment, including steatosis, alterations r", "tokenized_content": [2, 6095, 4047, 3, 4426, 25685, 1977, 3258, 18, 2176, 1977, 7903, 1988, 5358, 3095, 8655, 1927, 6095, 4047, 2810, 1942, 15665, 25033, 2830, 1021, 2311, 16, 2710, 16387, 16, 5996, 3]}, "items": [{"id": "p_1548", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1549", "content": "steatosis [SEP] exists of hepatic injury due to amiodarone treatment, including steatosis, alterations resembling alcoholic hepatitis, cholestatic hepati", "tokenized_content": [2, 16387, 3, 8655, 1927, 6095, 4047, 2810, 1942, 15665, 25033, 2830, 1021, 2311, 16, 2710, 16387, 16, 5996, 18994, 15521, 7977, 16, 21211, 2479, 5746, 1033, 3]}, "items": [{"id": "p_1549", "content": "Fatty Liver [SEP] Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usua", "score": 1, "type": null, "tokenized_content": [2, 5934, 3568, 3, 4486, 8946, 1927, 1920, 6095, 19223, 2094, 3864, 1922, 43, 7463, 17, 12669, 3568, 18, 1920, 4552, 4486, 4858, 1977, 2022, 12169, 3]}]}
{"query": {"id": "q_1550", "content": "alcoholic hepatitis [SEP] iodarone treatment, including steatosis, alterations resembling alcoholic hepatitis, cholestatic hepatitis and micronodular cirrhosis of the liver.", "tokenized_content": [2, 15521, 7977, 3, 8594, 25685, 2311, 16, 2710, 16387, 16, 5996, 18994, 15521, 7977, 16, 21211, 2479, 7977, 1930, 13094, 1986, 2168, 11260, 1927, 1920, 3568, 18, 3]}, "items": [{"id": "p_1550", "content": "Hepatitis, Alcoholic [SEP] INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 15521, 3, 4531, 1927, 1920, 3568, 2810, 1942, 4284, 7764, 18, 2176, 1977, 4378, 2007, 7476, 1927, 9919, 16, 8946, 2007, 8508, 16, 1930, 3]}]}
{"query": {"id": "q_1551", "content": "cirrhosis of the liver [SEP] ing alcoholic hepatitis, cholestatic hepatitis and micronodular cirrhosis of the liver. Patients receiving amiodarone should be regularly screened wit", "tokenized_content": [2, 11260, 1927, 1920, 3568, 3, 30393, 15521, 7977, 16, 21211, 2479, 7977, 1930, 13094, 1986, 2168, 11260, 1927, 1920, 3568, 18, 2132, 5962, 15665, 25033, 2830, 1021, 3066, 1998, 13487, 3]}, "items": [{"id": "p_1551", "content": "Liver Cirrhosis [SEP] Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably ", "score": 1, "type": null, "tokenized_content": [2, 3568, 11260, 3, 3568, 2573, 1922, 2154, 1920, 2791, 27469, 16, 1920, 10461, 4541, 12843, 16, 1930, 1920, 6095, 9335, 2162, 2252, 2309, 3458, 3]}]}
{"query": {"id": "q_1552", "content": "cholestatic injury [SEP] zyme levels. Therapy should be discontinued on the suspicion of cholestatic injury or hepatomegaly.", "tokenized_content": [2, 21211, 2479, 4047, 3, 15856, 1021, 2428, 18, 3181, 3066, 1998, 16087, 1990, 1920, 18419, 1927, 21211, 2479, 4047, 2014, 5746, 19323, 18, 3]}, "items": [{"id": "p_1552", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_1553", "content": "hepatomegaly [SEP] hould be discontinued on the suspicion of cholestatic injury or hepatomegaly.", "tokenized_content": [2, 5746, 19323, 3, 6673, 2248, 1998, 16087, 1990, 1920, 18419, 1927, 21211, 2479, 4047, 2014, 5746, 19323, 18, 3]}, "items": [{"id": "p_1553", "content": "Hepatomegaly [SEP] Enlargement of the liver.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5746, 19323, 3, 16363, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_1554", "content": "Catalepsy [SEP] Catalepsy induced by combinations of ketamine and morphine: potentiation,", "tokenized_content": [2, 4233, 9431, 1012, 3, 4233, 9431, 1012, 2719, 2007, 7763, 1927, 14049, 1930, 11553, 30, 16020, 16, 3]}, "items": [{"id": "p_1554", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_1555", "content": "ketamine [SEP] Catalepsy induced by combinations of ketamine and morphine: potentiation, antagonism, tolerance and cross-tol", "tokenized_content": [2, 14049, 3, 4233, 9431, 1012, 2719, 2007, 7763, 1927, 14049, 1930, 11553, 30, 16020, 16, 18394, 16, 6555, 1930, 3567, 17, 21930, 3]}, "items": [{"id": "p_1555", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_1556", "content": "morphine [SEP] Catalepsy induced by combinations of ketamine and morphine: potentiation, antagonism, tolerance and cross-tolerance in the", "tokenized_content": [2, 11553, 3, 4233, 9431, 1012, 2719, 2007, 7763, 1927, 14049, 1930, 11553, 30, 16020, 16, 18394, 16, 6555, 1930, 3567, 17, 6555, 1922, 1920, 3]}, "items": [{"id": "p_1556", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_1557", "content": "ketamine [SEP] Previous studies demonstrated that both ketamine and morphine induced analgesia and catalepsy in the rat. Pre-tr", "tokenized_content": [2, 14049, 3, 2555, 2351, 3161, 1988, 2321, 14049, 1930, 11553, 2719, 14695, 1930, 4233, 9431, 1012, 1922, 1920, 3067, 18, 2097, 17, 2025, 3]}, "items": [{"id": "p_1557", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_1558", "content": "morphine [SEP] Previous studies demonstrated that both ketamine and morphine induced analgesia and catalepsy in the rat. Pre-treatment with ", "tokenized_content": [2, 11553, 3, 2555, 2351, 3161, 1988, 2321, 14049, 1930, 11553, 2719, 14695, 1930, 4233, 9431, 1012, 1922, 1920, 3067, 18, 2097, 17, 2311, 1956, 3]}, "items": [{"id": "p_1558", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_1559", "content": "analgesia [SEP] us studies demonstrated that both ketamine and morphine induced analgesia and catalepsy in the rat. Pre-treatment with ketamine produced ", "tokenized_content": [2, 14695, 3, 2022, 2351, 3161, 1988, 2321, 14049, 1930, 11553, 2719, 14695, 1930, 4233, 9431, 1012, 1922, 1920, 3067, 18, 2097, 17, 2311, 1956, 14049, 4152, 3]}, "items": [{"id": "p_1559", "content": "Pain Insensitivity, Congenital [SEP] A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent cor", "score": 1, "type": null, "tokenized_content": [2, 3594, 30055, 16, 9901, 3, 43, 4741, 4378, 2007, 2063, 11307, 2055, 1942, 3594, 4281, 1920, 3682, 1942, 7279, 24218, 2037, 2447, 17, 24218, 5458, 18, 7685, 2233, 3]}]}
{"query": {"id": "q_1560", "content": "catalepsy [SEP] onstrated that both ketamine and morphine induced analgesia and catalepsy in the rat. Pre-treatment with ketamine produced cross-toleranc", "tokenized_content": [2, 4233, 9431, 1012, 3, 24335, 25957, 1988, 2321, 14049, 1930, 11553, 2719, 14695, 1930, 4233, 9431, 1012, 1922, 1920, 3067, 18, 2097, 17, 2311, 1956, 14049, 4152, 3567, 17, 4977, 3]}, "items": [{"id": "p_1560", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_1561", "content": "cataleptic [SEP] not induce cross-tolerance to ketamine but rather augmented the cataleptic response; this augmentation was attributed to residual morphine", "tokenized_content": [2, 4233, 17920, 3, 2084, 4769, 3567, 17, 6555, 1942, 14049, 2308, 4356, 13553, 1920, 4233, 17920, 2644, 31, 2052, 16493, 1982, 6898, 1942, 6615, 11553, 3]}, "items": [{"id": "p_1561", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_1562", "content": "rigidity [SEP] tive doses of morphine. Latency to the loss of righting reflex, rigidity and behavior on recovery, reflected the relative predominance o", "tokenized_content": [2, 20471, 3, 8685, 1961, 5312, 1927, 11553, 18, 9393, 1942, 1920, 3257, 1927, 3659, 1941, 11573, 16, 20471, 1930, 3379, 1990, 5241, 16, 8830, 1920, 3338, 19585, 57, 3]}, "items": [{"id": "p_1562", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_1563", "content": "Naloxone [SEP] ative predominance of ketamine or morphine in each combination. Naloxone inhibited the induced cataleptic effects. The degree and time c", "tokenized_content": [2, 21926, 3, 2019, 2320, 19585, 1927, 14049, 2014, 11553, 1922, 2362, 3921, 18, 21926, 5069, 1920, 2719, 4233, 17920, 2564, 18, 1920, 4647, 1930, 2367, 45, 3]}, "items": [{"id": "p_1563", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_1564", "content": "naloxone [SEP] r, asymmetry of cross-tolerance and a widely-different ID50 for naloxone would argue against an action at a single opioid site.", "tokenized_content": [2, 21926, 3, 60, 16, 13337, 1927, 3567, 17, 6555, 1930, 43, 5673, 17, 2413, 2313, 3382, 1958, 21926, 2962, 13451, 3316, 1925, 4615, 2019, 43, 2957, 9384, 3200, 18, 3]}, "items": [{"id": "p_1564", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_1565", "content": "Acute renal failure [SEP] Acute renal failure in patients with AIDS on tenofovir while receiving prolonged va", "tokenized_content": [2, 3939, 4604, 4574, 3, 3939, 4604, 4574, 1922, 2132, 1956, 8494, 1990, 29122, 2679, 5962, 7171, 9315, 3]}, "items": [{"id": "p_1565", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1566", "content": "AIDS [SEP] Acute renal failure in patients with AIDS on tenofovir while receiving prolonged vancomycin course for os", "tokenized_content": [2, 8494, 3, 3939, 4604, 4574, 1922, 2132, 1956, 8494, 1990, 29122, 2679, 5962, 7171, 16100, 4914, 1958, 3125, 3]}, "items": [{"id": "p_1566", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_1567", "content": "tenofovir [SEP] Acute renal failure in patients with AIDS on tenofovir while receiving prolonged vancomycin course for osteomyelitis.", "tokenized_content": [2, 29122, 3, 3939, 4604, 4574, 1922, 2132, 1956, 8494, 1990, 29122, 2679, 5962, 7171, 16100, 4914, 1958, 28420, 18, 3]}, "items": [{"id": "p_1567", "content": "tenofovir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29122, 3, 3]}]}
{"query": {"id": "q_1568", "content": "vancomycin [SEP] re in patients with AIDS on tenofovir while receiving prolonged vancomycin course for osteomyelitis.", "tokenized_content": [2, 16100, 3, 1964, 1922, 2132, 1956, 8494, 1990, 29122, 2679, 5962, 7171, 16100, 4914, 1958, 28420, 18, 3]}, "items": [{"id": "p_1568", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_1569", "content": "osteomyelitis [SEP] DS on tenofovir while receiving prolonged vancomycin course for osteomyelitis.", "tokenized_content": [2, 28420, 3, 4473, 1990, 29122, 2679, 5962, 7171, 16100, 4914, 1958, 28420, 18, 3]}, "items": [{"id": "p_1569", "content": "Osteomyelitis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28420, 3, 3]}]}
{"query": {"id": "q_1570", "content": "Renal failure [SEP] Renal failure developed after a prolonged course of vancomycin therapy in 2 p", "tokenized_content": [2, 4604, 4574, 3, 4604, 4574, 3530, 2256, 43, 7171, 4914, 1927, 16100, 3181, 1922, 22, 58, 3]}, "items": [{"id": "p_1570", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_1571", "content": "vancomycin [SEP] Renal failure developed after a prolonged course of vancomycin therapy in 2 patients who were receiving tenofovir disoproxil f", "tokenized_content": [2, 16100, 3, 4604, 4574, 3530, 2256, 43, 7171, 4914, 1927, 16100, 3181, 1922, 22, 2132, 2746, 1985, 5962, 29122, 2054, 12964, 18068, 1024, 48, 3]}, "items": [{"id": "p_1571", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_1572", "content": "tenofovir disoproxil fumarate [SEP] d course of vancomycin therapy in 2 patients who were receiving tenofovir disoproxil fumarate as part of an antiretroviral regimen. Tenofovir has been implic", "tokenized_content": [2, 29122, 2054, 12964, 18068, 1024, 28343, 3, 46, 4914, 1927, 16100, 3181, 1922, 22, 2132, 2746, 1985, 5962, 29122, 2054, 12964, 18068, 1024, 28343, 1966, 3131, 1927, 1925, 14255, 8607, 3]}, "items": [{"id": "p_1572", "content": "tenofovir disoproxil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29122, 2054, 12964, 18068, 1024, 3, 3]}]}
{"query": {"id": "q_1573", "content": "Tenofovir [SEP] fovir disoproxil fumarate as part of an antiretroviral regimen. Tenofovir has been implicated in the development of Fanconi syndrome and ", "tokenized_content": [2, 29122, 3, 21020, 1996, 2054, 12964, 18068, 1024, 28343, 1966, 3131, 1927, 1925, 14255, 8607, 18, 29122, 2258, 2252, 6835, 1922, 1920, 2740, 1927, 17431, 13339, 4741, 1930, 3]}, "items": [{"id": "p_1573", "content": "tenofovir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29122, 3, 3]}]}
{"query": {"id": "q_1574", "content": "Fanconi syndrome [SEP] al regimen. Tenofovir has been implicated in the development of Fanconi syndrome and renal insufficiency because of its effects on the proximal ", "tokenized_content": [2, 17431, 13339, 4741, 3, 1969, 8607, 18, 29122, 2258, 2252, 6835, 1922, 1920, 2740, 1927, 17431, 13339, 4741, 1930, 4604, 14566, 2882, 1927, 2496, 2564, 1990, 1920, 6863, 3]}, "items": [{"id": "p_1574", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_1575", "content": "renal insufficiency [SEP]  has been implicated in the development of Fanconi syndrome and renal insufficiency because of its effects on the proximal renal tubule. Vancomycin", "tokenized_content": [2, 4604, 14566, 3, 2258, 2252, 6835, 1922, 1920, 2740, 1927, 17431, 13339, 4741, 1930, 4604, 14566, 2882, 1927, 2496, 2564, 1990, 1920, 6863, 4604, 17946, 18, 16100, 3]}, "items": [{"id": "p_1575", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_1576", "content": "Vancomycin [SEP] ufficiency because of its effects on the proximal renal tubule. Vancomycin nephrotoxicity is infrequent but may result from coadministrati", "tokenized_content": [2, 16100, 3, 18661, 19894, 3349, 2589, 2882, 1927, 2496, 2564, 1990, 1920, 6863, 4604, 17946, 18, 16100, 27880, 1977, 21587, 2308, 2278, 3211, 2037, 29818, 8547, 3139, 1968, 3]}, "items": [{"id": "p_1576", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_1577", "content": "nephrotoxicity [SEP] because of its effects on the proximal renal tubule. Vancomycin nephrotoxicity is infrequent but may result from coadministration with a nephr", "tokenized_content": [2, 27880, 3, 2882, 1927, 2496, 2564, 1990, 1920, 6863, 4604, 17946, 18, 16100, 27880, 1977, 21587, 2308, 2278, 3211, 2037, 29818, 8547, 3934, 1956, 43, 7737, 1005, 3]}, "items": [{"id": "p_1577", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1578", "content": "nephrotoxic [SEP] because of its effects on the proximal renal tubule. Vancomycin nephrotoxicity is infrequent but may result from coadministration with a ne", "tokenized_content": [2, 22994, 10605, 3, 2882, 1927, 2496, 2564, 1990, 1920, 6863, 4604, 17946, 18, 16100, 27880, 1977, 21587, 2308, 2278, 3211, 2037, 29818, 8547, 3934, 1956, 43, 2069, 3]}, "items": [{"id": "p_1578", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1579", "content": "tenofovir [SEP] d course of vancomycin therapy in 2 patients who were receiving tenofovir disoproxil fumarate as part of an antiretroviral regimen. Tenof", "tokenized_content": [2, 29122, 3, 46, 4914, 1927, 16100, 3181, 1922, 22, 2132, 2746, 1985, 5962, 29122, 2054, 12964, 18068, 1024, 28343, 1966, 3131, 1927, 1925, 14255, 8607, 18, 5656, 4199, 3]}, "items": [{"id": "p_1579", "content": "tenofovir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29122, 3, 3]}]}
{"query": {"id": "q_1580", "content": "renal failure [SEP] Clinicians should be aware that tenofovir may raise the risk of renal failure during prolonged administration of vancomycin.", "tokenized_content": [2, 4604, 4574, 3, 8575, 3066, 1998, 11207, 1988, 29122, 2278, 13701, 1920, 2565, 1927, 4604, 4574, 2409, 7171, 4183, 1927, 16100, 18, 3]}, "items": [{"id": "p_1580", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_1581", "content": "leukoencephalopathy [SEP] Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.", "tokenized_content": [2, 5104, 29159, 6522, 3, 7083, 5104, 29159, 6522, 1956, 5235, 17, 3189, 6544, 1922, 5318, 9336, 18, 3]}, "items": [{"id": "p_1581", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1582", "content": "stroke [SEP] Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.", "tokenized_content": [2, 5235, 3, 7083, 5104, 29159, 6522, 1956, 5235, 17, 3189, 6544, 1922, 5318, 9336, 18, 3]}, "items": [{"id": "p_1582", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1583", "content": "leukoencephalopathy [SEP] BACKGROUND: A transient leukoencephalopathy mimicking cerebrovascular accident has been described as a comp", "tokenized_content": [2, 5104, 29159, 6522, 3, 3872, 30, 43, 6809, 5104, 29159, 6522, 18072, 16221, 17713, 2258, 2252, 2910, 1966, 43, 2059, 3]}, "items": [{"id": "p_1583", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1584", "content": "cerebrovascular accident [SEP] BACKGROUND: A transient leukoencephalopathy mimicking cerebrovascular accident has been described as a complication of chemotherapy, most comm", "tokenized_content": [2, 16221, 17713, 3, 3872, 30, 43, 6809, 5104, 29159, 6522, 18072, 16221, 17713, 2258, 2252, 2910, 1966, 43, 9388, 1927, 5318, 16, 2501, 2689, 3]}, "items": [{"id": "p_1584", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_1585", "content": "methotrexate [SEP] ion of chemotherapy, most commonly in recipients of intrathecal methotrexate for childhood leukaemia. Recently published neuroimaging data s", "tokenized_content": [2, 18031, 3, 4755, 1927, 5318, 16, 2501, 5384, 1922, 9336, 1927, 22782, 18031, 1958, 7238, 23099, 18, 3998, 4586, 13793, 2230, 61, 3]}, "items": [{"id": "p_1585", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_1586", "content": "leukaemia [SEP] ommonly in recipients of intrathecal methotrexate for childhood leukaemia. Recently published neuroimaging data suggest a common pathophy", "tokenized_content": [2, 23099, 3, 7254, 3947, 1954, 1922, 9336, 1927, 22782, 18031, 1958, 7238, 23099, 18, 3998, 4586, 13793, 2230, 3220, 43, 3059, 2450, 2688, 1012, 3]}, "items": [{"id": "p_1586", "content": "Leukemia [SEP] A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukoc", "score": 1, "type": null, "tokenized_content": [2, 8111, 3, 43, 7529, 16, 6558, 2573, 1927, 1920, 2877, 17, 7402, 7393, 16, 4378, 2007, 22797, 4031, 1930, 2740, 1927, 5104, 1994, 3]}]}
{"query": {"id": "q_1587", "content": "stroke [SEP]  for single reports and case series of patients presenting with stroke-like episodes while receiving systemic or intrathecal chemother", "tokenized_content": [2, 5235, 3, 1958, 2957, 4710, 1930, 3087, 4696, 1927, 2132, 8326, 1956, 5235, 17, 3189, 9232, 2679, 5962, 5510, 2014, 22782, 12776, 2380, 3]}, "items": [{"id": "p_1587", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1588", "content": "cerebrovascular accidents [SEP] ded studies providing detailed neuroimaging data. Patients with cerebrovascular accidents were excluded. RESULTS: We identified 27 reports of toxic leuko", "tokenized_content": [2, 16221, 19556, 3, 11481, 2351, 5453, 5720, 13793, 2230, 18, 2132, 1956, 16221, 19556, 1985, 5450, 18, 2274, 30, 2038, 2899, 3225, 4710, 1927, 6161, 5104, 1037, 3]}, "items": [{"id": "p_1588", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_1589", "content": "5-fluorouracil [SEP]  in patients treated with methotrexate (intrathecal, systemic), 5-fluorouracil and its derivative carmofur, and capecitabine. Diffusion weight", "tokenized_content": [2, 25, 17, 21353, 3, 1922, 2132, 2868, 1956, 18031, 12, 22782, 16, 5510, 13, 16, 25, 17, 21353, 1930, 2496, 10533, 2279, 12492, 19073, 1005, 16, 1930, 28720, 18, 6601, 3]}, "items": [{"id": "p_1589", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1590", "content": "carmofur [SEP] xate (intrathecal, systemic), 5-fluorouracil and its derivative carmofur, and capecitabine. Diffusion weighted imaging (DWI) of all pati", "tokenized_content": [2, 2279, 12492, 19073, 1005, 3, 23447, 2057, 12, 22782, 16, 5510, 13, 16, 25, 17, 21353, 1930, 2496, 10533, 2279, 12492, 19073, 1005, 16, 1930, 28720, 18, 6601, 7370, 3755, 3]}, "items": [{"id": "p_1590", "content": "1-hexylcarbamoyl-5-fluorouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 7142, 2199, 15339, 7972, 12492, 2199, 17, 25, 17, 21353, 3, 3]}]}
{"query": {"id": "q_1591", "content": "capecitabine [SEP] cal, systemic), 5-fluorouracil and its derivative carmofur, and capecitabine. Diffusion weighted imaging (DWI) of all patients revealed well", "tokenized_content": [2, 28720, 3, 2570, 16, 5510, 13, 16, 25, 17, 21353, 1930, 2496, 10533, 2279, 12492, 19073, 1005, 16, 1930, 28720, 18, 6601, 7370, 3755, 12, 20305, 13, 1927, 2136, 2132, 3]}, "items": [{"id": "p_1591", "content": "capecitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28720, 3, 3]}]}
{"query": {"id": "q_1592", "content": "lesions within the subcortical white matter [SEP] ing (DWI) of all patients revealed well demarcated hyperintense lesions within the subcortical white matter of the cerebral hemispheres and the corpus callosum, correspond", "tokenized_content": [2, 4518, 2651, 1920, 16921, 4511, 6537, 3, 30393, 12, 20305, 13, 1927, 2136, 2132, 3404, 2486, 25702, 1981, 22432, 4480, 4518, 2651, 1920, 16921, 4511, 6537, 1927, 1920, 6329, 21098, 3]}, "items": [{"id": "p_1592", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1593", "content": "white matter abnormalities [SEP] rsion recovery (FLAIR) sequences frequently revealed persistent white matter abnormalities. CONCLUSIONS: Several pathophysiological models of delayed leuk", "tokenized_content": [2, 4511, 6537, 6754, 3, 4366, 2001, 5241, 12, 28321, 13, 3709, 5467, 3404, 7733, 4511, 6537, 6754, 18, 4355, 30, 2980, 15421, 3130, 1927, 7083, 5104, 3]}, "items": [{"id": "p_1593", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1594", "content": "cytotoxic oedema within cerebral white matter [SEP] ve been proposed. DWI findings in this cohort are indicative of cytotoxic oedema within cerebral white matter and lend support to an at least partially reversible metabolic ", "tokenized_content": [2, 8377, 24110, 2651, 6329, 4511, 6537, 3, 3428, 2252, 4211, 18, 20305, 3056, 1922, 2052, 4382, 2032, 10779, 1927, 8377, 24110, 2651, 6329, 4511, 6537, 1930, 30217, 3373, 1942, 1925, 3]}, "items": [{"id": "p_1594", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_1595", "content": "norepinephrine [SEP] Down-regulation of norepinephrine transporter function induced by chronic administration of desip", "tokenized_content": [2, 16436, 3, 3292, 17, 3640, 1927, 16436, 9054, 2347, 2719, 2007, 3724, 4183, 1927, 2270, 2049, 3]}, "items": [{"id": "p_1595", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1596", "content": "desipramine [SEP] hrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-i", "tokenized_content": [2, 2270, 27085, 3, 3668, 2053, 9054, 2347, 2719, 2007, 3724, 4183, 1927, 2270, 27085, 9486, 1942, 1920, 10076, 1927, 3802, 1927, 3076, 17, 25118, 17, 51, 3]}, "items": [{"id": "p_1596", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_1597", "content": "convulsions [SEP] g to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anestheti", "tokenized_content": [2, 4772, 19389, 3, 49, 1942, 1920, 10076, 1927, 3802, 1927, 3076, 17, 25118, 17, 2719, 4772, 19389, 1930, 1920, 20806, 2001, 2007, 2081, 17, 4183, 1956, 3076, 6176, 4988, 3]}, "items": [{"id": "p_1597", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1598", "content": "norepinephrine [SEP] Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in rela", "tokenized_content": [2, 16436, 3, 5996, 1927, 16436, 9054, 12, 3254, 13, 2347, 2007, 3724, 3523, 1927, 3254, 1922, 22247, 3]}, "items": [{"id": "p_1598", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1599", "content": "seizures [SEP] on by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice. D", "tokenized_content": [2, 10060, 3, 1990, 2007, 3724, 3523, 1927, 3254, 1922, 6147, 1942, 12770, 1942, 10060, 4769, 2007, 9045, 1930, 3076, 25118, 1985, 3942, 1922, 2518, 18, 46, 3]}, "items": [{"id": "p_1599", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1600", "content": "cocaine [SEP] ition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice. Daily administratio", "tokenized_content": [2, 9045, 3, 2176, 2001, 1927, 3254, 1922, 6147, 1942, 12770, 1942, 10060, 4769, 2007, 9045, 1930, 3076, 25118, 1985, 3942, 1922, 2518, 18, 4692, 10473, 1968, 1037, 3]}, "items": [{"id": "p_1600", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1601", "content": "desipramine [SEP] local anesthetics were studied in mice. Daily administration of desipramine, an inhibitor of the NET, for 5 days decreased [(3)H]norepineph", "tokenized_content": [2, 2270, 27085, 3, 3076, 25118, 1985, 3942, 1922, 2518, 18, 4692, 4183, 1927, 2270, 27085, 16, 1925, 4106, 1927, 1920, 3254, 16, 1958, 25, 3000, 3261, 37, 12, 23, 13, 3]}, "items": [{"id": "p_1601", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_1602", "content": "lidocaine [SEP] pus but not cortex, striatum or amygdalae. Co-administration of lidocaine, bupivacaine or tricaine with desipramine reversed this effect.", "tokenized_content": [2, 19567, 3, 24093, 2308, 2084, 4997, 16, 11259, 2014, 10637, 1021, 18, 2081, 17, 4183, 1927, 19567, 16, 25473, 2014, 12258, 5966, 1956, 2270, 27085, 9432, 2052, 2495, 18, 3]}, "items": [{"id": "p_1602", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_1603", "content": "bupivacaine [SEP]  cortex, striatum or amygdalae. Co-administration of lidocaine, bupivacaine or tricaine with desipramine reversed this effect. Daily treatm", "tokenized_content": [2, 25473, 3, 4997, 16, 11259, 2014, 10637, 1021, 18, 2081, 17, 4183, 1927, 19567, 16, 25473, 2014, 12258, 5966, 1956, 2270, 27085, 9432, 2052, 2495, 18, 4692, 2297, 1035, 3]}, "items": [{"id": "p_1603", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_1604", "content": "tricaine [SEP] um or amygdalae. Co-administration of lidocaine, bupivacaine or tricaine with desipramine reversed this effect. Daily treatment of cocai", "tokenized_content": [2, 12258, 5966, 3, 8736, 2014, 10637, 1021, 18, 2081, 17, 4183, 1927, 19567, 16, 25473, 2014, 12258, 5966, 1956, 2270, 27085, 9432, 2052, 2495, 18, 4692, 2311, 1927, 6880, 5504, 3]}, "items": [{"id": "p_1604", "content": "tricaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12258, 5966, 3, 3]}]}
{"query": {"id": "q_1605", "content": "convulsions [SEP] mine increased the incidence of appearance of lidocaine-induced convulsions and decreased that of cocaine-induced convulsions. Co-administr", "tokenized_content": [2, 4772, 19389, 3, 24165, 2502, 1920, 4332, 1927, 7818, 1927, 19567, 17, 2719, 4772, 19389, 1930, 3261, 1988, 1927, 9045, 17, 2719, 4772, 19389, 18, 2081, 17, 10473, 3]}, "items": [{"id": "p_1605", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1606", "content": "convulsive [SEP] istration of lidocaine with desipramine reversed the changes of convulsive activity of lidocaine and cocaine induced by repeated administr", "tokenized_content": [2, 4772, 13042, 3, 1977, 6003, 1927, 19567, 1956, 2270, 27085, 9432, 1920, 2840, 1927, 4772, 13042, 2455, 1927, 19567, 1930, 9045, 2719, 2007, 5116, 10473, 3]}, "items": [{"id": "p_1606", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1607", "content": "Na [SEP] e-induced sensitization of lidocaine convulsions. Inhibition of Na(+) channels by local anesthetics may regulate desipramine-induc", "tokenized_content": [2, 4049, 3, 47, 17, 2719, 12770, 1927, 19567, 4772, 19389, 18, 3523, 1927, 4049, 12, 15, 13, 5628, 2007, 3076, 25118, 2278, 5741, 2270, 27085, 17, 4320, 3]}, "items": [{"id": "p_1607", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1608", "content": "Desipramine [SEP] n of cocaine induces up-regulation of hippocampal NET function. Desipramine-induced sensitization of lidocaine seizures may have a mechanis", "tokenized_content": [2, 2270, 27085, 3, 56, 1927, 9045, 6387, 2353, 17, 3640, 1927, 7636, 3254, 2347, 18, 2270, 27085, 17, 2719, 12770, 1927, 19567, 10060, 2278, 2162, 43, 2665, 1937, 3]}, "items": [{"id": "p_1608", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_1609", "content": "anemia [SEP] Definition and management of anemia in patients infected with hepatitis C virus.", "tokenized_content": [2, 10679, 3, 6600, 1930, 4280, 1927, 10679, 1922, 2132, 4014, 1956, 7977, 45, 3413, 18, 3]}, "items": [{"id": "p_1609", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_1610", "content": "infected with hepatitis C virus [SEP] Definition and management of anemia in patients infected with hepatitis C virus.", "tokenized_content": [2, 4014, 1956, 7977, 45, 3413, 3, 6600, 1930, 4280, 1927, 10679, 1922, 2132, 4014, 1956, 7977, 45, 3413, 18, 3]}, "items": [{"id": "p_1610", "content": "Hepatitis C [SEP] INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 day", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 7977, 45, 3413, 16, 43, 2957, 17, 10338, 3146, 3413, 18, 2496, 5282, 3047, 1977, 2627, 17, 3865, 3007, 3]}]}
{"query": {"id": "q_1611", "content": "Chronic infection with hepatitis C virus [SEP] Chronic infection with hepatitis C virus (HCV) can progress to cirrhosis, hepatocellular carcinoma, and ", "tokenized_content": [2, 3724, 2909, 1956, 7977, 45, 3413, 3, 3724, 2909, 1956, 7977, 45, 3413, 12, 6749, 13, 2112, 4782, 1942, 11260, 16, 12457, 5373, 16, 1930, 3]}, "items": [{"id": "p_1611", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1612", "content": "cirrhosis [SEP] Chronic infection with hepatitis C virus (HCV) can progress to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. The cur", "tokenized_content": [2, 11260, 3, 3724, 2909, 1956, 7977, 45, 3413, 12, 6749, 13, 2112, 4782, 1942, 11260, 16, 12457, 5373, 16, 1930, 2482, 17, 3587, 3568, 2573, 18, 1920, 3580, 3]}, "items": [{"id": "p_1612", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_1613", "content": "hepatocellular carcinoma [SEP] fection with hepatitis C virus (HCV) can progress to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. The current best treatment for HC", "tokenized_content": [2, 12457, 5373, 3, 16688, 1929, 1956, 7977, 45, 3413, 12, 6749, 13, 2112, 4782, 1942, 11260, 16, 12457, 5373, 16, 1930, 2482, 17, 3587, 3568, 2573, 18, 1920, 3214, 4534, 3]}, "items": [{"id": "p_1613", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_1614", "content": "end-stage liver disease [SEP]  (HCV) can progress to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. The current best treatment for HCV infection is combination th", "tokenized_content": [2, 2482, 17, 3587, 3568, 2573, 3, 12, 6749, 13, 2112, 4782, 1942, 11260, 16, 12457, 5373, 16, 1930, 2482, 17, 3587, 3568, 2573, 18, 1920, 3214, 4534, 2311, 1958, 6749, 3]}, "items": [{"id": "p_1614", "content": "End Stage Liver Disease [SEP] Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2482, 3587, 3568, 2573, 3, 3948, 3587, 1927, 43, 3568, 2573, 2469, 1920, 3568, 4574, 1977, 14104, 1930, 3568, 6530, 1977, 4500, 18, 3]}]}
{"query": {"id": "q_1615", "content": "HCV infection [SEP] ma, and end-stage liver disease. The current best treatment for HCV infection is combination therapy with pegylated interferon and ribavirin.", "tokenized_content": [2, 6749, 2909, 3, 2488, 16, 1930, 2482, 17, 3587, 3568, 2573, 18, 1920, 3214, 4534, 2311, 1958, 6749, 2909, 1977, 3921, 3181, 1956, 24208, 10001, 1930, 23635, 18, 3]}, "items": [{"id": "p_1615", "content": "Hepatitis C [SEP] INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 day", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 7977, 45, 3413, 16, 43, 2957, 17, 10338, 3146, 3413, 18, 2496, 5282, 3047, 1977, 2627, 17, 3865, 3007, 3]}]}
{"query": {"id": "q_1616", "content": "interferon [SEP] eatment for HCV infection is combination therapy with pegylated interferon and ribavirin. Although this regimen produces sustained virolog", "tokenized_content": [2, 10001, 3, 13619, 2017, 1958, 6749, 2909, 1977, 3921, 3181, 1956, 24208, 10001, 1930, 23635, 18, 2876, 2052, 8607, 9300, 7637, 16019, 3]}, "items": [{"id": "p_1616", "content": "Interferons [SEP] Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different v", "score": 1, "type": null, "tokenized_content": [2, 10001, 1036, 3, 2697, 8366, 2007, 13416, 2094, 1922, 2644, 1942, 43, 4743, 5386, 1927, 23329, 18, 2611, 7909, 3554, 3316, 3086, 2413, 64, 3]}]}
{"query": {"id": "q_1617", "content": "ribavirin [SEP]  infection is combination therapy with pegylated interferon and ribavirin. Although this regimen produces sustained virologic responses (", "tokenized_content": [2, 23635, 3, 2909, 1977, 3921, 3181, 1956, 24208, 10001, 1930, 23635, 18, 2876, 2052, 8607, 9300, 7637, 27657, 3387, 12, 3]}, "items": [{"id": "p_1617", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1618", "content": "hemolytic anemia [SEP] patients, it can be associated with a potentially dose-limiting hemolytic anemia. Hemoglobin concentrations decrease mainly as a result of ribav", "tokenized_content": [2, 21515, 10679, 3, 2132, 16, 2176, 2112, 1998, 2458, 1956, 43, 5063, 3253, 17, 8051, 21515, 10679, 18, 9652, 3295, 3714, 4994, 1966, 43, 3211, 1927, 5216, 2507, 3]}, "items": [{"id": "p_1618", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_1619", "content": "hemolysis [SEP] concentrations decrease mainly as a result of ribavirin-induced hemolysis, and this anemia can be problematic in patients with HCV infect", "tokenized_content": [2, 22409, 3, 3295, 3714, 4994, 1966, 43, 3211, 1927, 23635, 17, 2719, 22409, 16, 1930, 2052, 10679, 2112, 1998, 13624, 1922, 2132, 1956, 6749, 15119, 3]}, "items": [{"id": "p_1619", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_1620", "content": "anemia [SEP] it can be associated with a potentially dose-limiting hemolytic anemia. Hemoglobin concentrations decrease mainly as a result of ribav", "tokenized_content": [2, 10679, 3, 2176, 2112, 1998, 2458, 1956, 43, 5063, 3253, 17, 8051, 21515, 10679, 18, 9652, 3295, 3714, 4994, 1966, 43, 3211, 1927, 5216, 2507, 3]}, "items": [{"id": "p_1620", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_1621", "content": "cardiovascular disorders [SEP] with HCV infection, especially those who have comorbid renal or cardiovascular disorders. In general, anemia can increase the risk of morbidity and mort", "tokenized_content": [2, 5321, 4414, 3, 1956, 6749, 2909, 16, 4369, 2690, 2746, 2162, 9006, 4604, 2014, 5321, 4414, 18, 1922, 3335, 16, 10679, 2112, 2760, 1920, 2565, 1927, 7207, 1930, 22787, 3]}, "items": [{"id": "p_1621", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_1622", "content": "Viramidine [SEP] avirin-associated anemia but has other potential disadvantages. Viramidine, a liver-targeting prodrug of ribavirin, has the potential to m", "tokenized_content": [2, 2787, 25238, 2053, 3, 22731, 5572, 17, 2458, 10679, 2308, 2258, 2303, 2889, 18275, 18, 2787, 25238, 2053, 16, 43, 3568, 17, 5133, 21499, 1927, 23635, 16, 2258, 1920, 2889, 3]}, "items": [{"id": "p_1622", "content": "ribavirin amidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23635, 28813, 2053, 3, 3]}]}
{"query": {"id": "q_1623", "content": "chronic hepatitis C [SEP]  while decreasing the risk of hemolytic anemia in patients with chronic hepatitis C.", "tokenized_content": [2, 3724, 7977, 45, 3, 2679, 7742, 1920, 2565, 1927, 21515, 10679, 1922, 2132, 1956, 3724, 7977, 45, 18, 3]}, "items": [{"id": "p_1623", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1624", "content": "Calcium carbonate [SEP] Calcium carbonate toxicity: the updated milk-alkali syndrome; report of 3 cases a", "tokenized_content": [2, 5016, 17724, 3, 5016, 17724, 5532, 30, 1920, 13236, 7126, 17, 25178, 4741, 31, 3809, 1927, 23, 2919, 43, 3]}, "items": [{"id": "p_1624", "content": "Calcium Carbonate [SEP] Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically a", "score": 1, "type": null, "tokenized_content": [2, 5016, 17724, 3, 5056, 1935, 2687, 5016, 7012, 12, 19107, 1010, 13, 18, 1925, 12685, 5427, 16, 13891, 5427, 10201, 2014, 6561, 1988, 5110, 1922, 4899, 18, 2176, 1977, 2251, 25058, 43, 3]}]}
{"query": {"id": "q_1625", "content": "toxicity [SEP] Calcium carbonate toxicity: the updated milk-alkali syndrome; report of 3 cases and review", "tokenized_content": [2, 5532, 3, 5016, 17724, 5532, 30, 1920, 13236, 7126, 17, 25178, 4741, 31, 3809, 1927, 23, 2919, 1930, 3043, 3]}, "items": [{"id": "p_1625", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1626", "content": "milk-alkali syndrome [SEP] Calcium carbonate toxicity: the updated milk-alkali syndrome; report of 3 cases and review of the literature.", "tokenized_content": [2, 7126, 17, 25178, 4741, 3, 5016, 17724, 5532, 30, 1920, 13236, 7126, 17, 25178, 4741, 31, 3809, 1927, 23, 2919, 1930, 3043, 1927, 1920, 4431, 18, 3]}, "items": [{"id": "p_1626", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1627", "content": "calcium carbonate [SEP] OBJECTIVE: To describe 3 patients with calcium carbonate-induced hypercalcemia and gain insights into the cause and mana", "tokenized_content": [2, 5016, 17724, 3, 4470, 30, 1942, 5993, 23, 2132, 1956, 5016, 17724, 17, 2719, 25374, 9358, 1930, 5938, 8486, 2460, 1920, 3936, 1930, 2323, 1019, 3]}, "items": [{"id": "p_1627", "content": "Calcium Carbonate [SEP] Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically a", "score": 1, "type": null, "tokenized_content": [2, 5016, 17724, 3, 5056, 1935, 2687, 5016, 7012, 12, 19107, 1010, 13, 18, 1925, 12685, 5427, 16, 13891, 5427, 10201, 2014, 6561, 1988, 5110, 1922, 4899, 18, 2176, 1977, 2251, 25058, 43, 3]}]}
{"query": {"id": "q_1628", "content": "hypercalcemia [SEP] BJECTIVE: To describe 3 patients with calcium carbonate-induced hypercalcemia and gain insights into the cause and management of the milk-alk", "tokenized_content": [2, 25374, 9358, 3, 17840, 2451, 30, 1942, 5993, 23, 2132, 1956, 5016, 17724, 17, 2719, 25374, 9358, 1930, 5938, 8486, 2460, 1920, 3936, 1930, 4280, 1927, 1920, 7126, 17, 5638, 3]}, "items": [{"id": "p_1628", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1629", "content": "milk-alkali syndrome [SEP] calcemia and gain insights into the cause and management of the milk-alkali syndrome. METHODS: We report the clinical and laboratory data in 3 patie", "tokenized_content": [2, 7126, 17, 25178, 4741, 3, 2799, 3847, 1930, 5938, 8486, 2460, 1920, 3936, 1930, 4280, 1927, 1920, 7126, 17, 25178, 4741, 18, 2860, 30, 2038, 3809, 1920, 2535, 1930, 4542, 3]}, "items": [{"id": "p_1629", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1630", "content": "calcium [SEP] OBJECTIVE: To describe 3 patients with calcium carbonate-induced hypercalcemia and gain insights into the caus", "tokenized_content": [2, 5016, 3, 4470, 30, 1942, 5993, 23, 2132, 1956, 5016, 17724, 17, 2719, 25374, 9358, 1930, 5938, 8486, 2460, 1920, 3092, 3]}, "items": [{"id": "p_1630", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1631", "content": "acute renal insufficiency [SEP] literature on milk-alkali syndrome. RESULTS: The 3 patients had acute renal insufficiency, relative metabolic alkalosis, and low parathyroid hormone (PTH", "tokenized_content": [2, 3939, 4604, 14566, 3, 4431, 1990, 7126, 17, 25178, 4741, 18, 2274, 30, 1920, 23, 2132, 2430, 3939, 4604, 14566, 16, 3338, 4487, 14961, 2475, 16, 1930, 2330, 17152, 6365, 3]}, "items": [{"id": "p_1631", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1632", "content": "metabolic alkalosis [SEP] RESULTS: The 3 patients had acute renal insufficiency, relative metabolic alkalosis, and low parathyroid hormone (PTH), PTH-related peptide, and 1,", "tokenized_content": [2, 4487, 14961, 2475, 3, 2274, 30, 1920, 23, 2132, 2430, 3939, 4604, 14566, 16, 3338, 4487, 14961, 2475, 16, 1930, 2330, 17152, 6365, 12, 13330, 13, 16, 13330, 17, 2712, 3]}, "items": [{"id": "p_1632", "content": "Alkalosis [SEP] A pathological condition that removes acid or adds base to the body fluids.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14961, 2475, 3, 43, 6598, 2625, 1988, 21890, 2687, 2014, 17005, 5170, 1942, 1920, 3362, 13315, 18, 3]}]}
{"query": {"id": "q_1633", "content": "1,25-dihydroxyvitamin D [SEP] is, and low parathyroid hormone (PTH), PTH-related peptide, and 1,25-dihydroxyvitamin D concentrations. No malignant lesion was found. Treatment includ", "tokenized_content": [2, 21, 16, 2637, 17, 20684, 25418, 46, 3, 1977, 16, 1930, 2330, 17152, 6365, 12, 13330, 13, 16, 13330, 17, 2712, 4207, 16, 1930, 21, 16, 2637, 17, 20684, 25418, 3]}, "items": [{"id": "p_1633", "content": "1,25-dihydroxyvitamin D [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 2637, 17, 20684, 25418, 46, 3, 3]}]}
{"query": {"id": "q_1634", "content": "furosemide [SEP] . Treatment included aggressive hydration and varied amounts of furosemide. The 2 patients with the higher serum calcium concentrations re", "tokenized_content": [2, 30509, 3, 18, 2311, 3063, 8704, 16561, 1930, 6760, 6222, 1927, 30509, 18, 1920, 22, 2132, 1956, 1920, 2580, 3256, 5016, 3295, 1964, 3]}, "items": [{"id": "p_1634", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_1635", "content": "pamidronate [SEP]  patients with the higher serum calcium concentrations received pamidronate intravenously (60 and 30 mg, respectively), which caused severe", "tokenized_content": [2, 11888, 1960, 20161, 3, 2132, 1956, 1920, 2580, 3256, 5016, 3295, 4004, 11888, 1960, 20161, 15132, 12, 3276, 1930, 2627, 2786, 16, 2763, 13, 16, 2154, 4189, 4010, 3]}, "items": [{"id": "p_1635", "content": "pamidronate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11888, 1960, 20161, 3, 3]}]}
{"query": {"id": "q_1636", "content": "hypocalcemia [SEP] intravenously (60 and 30 mg, respectively), which caused severe hypocalcemia. Of the 3 patients, 2 were ingesting acceptable doses of elemen", "tokenized_content": [2, 30201, 9358, 3, 15132, 12, 3276, 1930, 2627, 2786, 16, 2763, 13, 16, 2154, 4189, 4010, 30201, 9358, 18, 1927, 1920, 23, 2132, 16, 22, 1985, 11378, 2104, 9630, 5312, 3]}, "items": [{"id": "p_1636", "content": "Hypocalcemia [SEP] Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle an", "score": 1, "type": null, "tokenized_content": [2, 30201, 9358, 3, 3378, 1927, 1920, 2877, 5016, 4535, 2791, 18, 10952, 3951, 28704, 6515, 11780, 24064, 16, 2016, 15525, 2156, 2819, 11, 61, 2105, 16, 3760, 1925, 3]}]}
{"query": {"id": "q_1637", "content": "Milk-alkali syndrome [SEP] he cases reported from early 1995 to November 2003. CONCLUSION: Milk-alkali syndrome may be a common cause of unexplained hypercalcemia and can be p", "tokenized_content": [2, 7126, 17, 25178, 4741, 3, 2234, 2919, 2568, 2037, 3120, 6719, 1942, 12832, 4450, 18, 4180, 30, 7126, 17, 25178, 4741, 2278, 1998, 43, 3059, 3936, 1927, 21109, 25374, 9358, 3]}, "items": [{"id": "p_1637", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1638", "content": "vitamin D [SEP] rathyroid hormone (PTH), PTH-related peptide, and 1,25-dihydroxyvitamin D concentrations. No malignant lesion was found. Treatment includ", "tokenized_content": [2, 6111, 46, 3, 3067, 30338, 12245, 6365, 12, 13330, 13, 16, 13330, 17, 2712, 4207, 16, 1930, 21, 16, 2637, 17, 20684, 25418, 46, 3295, 18, 2239, 6558, 5709, 1982, 3]}, "items": [{"id": "p_1638", "content": "Vitamin D [SEP] A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS ", "score": 1, "type": null, "tokenized_content": [2, 6111, 46, 3, 43, 6111, 1988, 5921, 2321, 17177, 8515, 3236, 3706, 1930, 11949, 5000, 3349, 2070, 3706, 16, 2154, 2162, 1920, 3059, 2495, 1927, 8444, 2014, 22700, 19507, 3441, 3]}]}
{"query": {"id": "q_1639", "content": "Pamidronate [SEP] iscontinuation of the calcium and vitamin D source is adequate. Pamidronate treatment is associated with considerable risk for hypocalcemia", "tokenized_content": [2, 11888, 1960, 20161, 3, 23924, 7562, 10874, 1927, 1920, 5016, 1930, 6111, 46, 4585, 1977, 7485, 18, 11888, 1960, 20161, 2311, 1977, 2458, 1956, 7743, 2565, 1958, 30201, 9358, 3]}, "items": [{"id": "p_1639", "content": "pamidronate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11888, 1960, 20161, 3, 3]}]}
{"query": {"id": "q_1640", "content": "ribavirin [SEP] Management strategies for ribavirin-induced hemolytic anemia in the treatment of hepatitis C: clini", "tokenized_content": [2, 23635, 3, 4280, 4762, 1958, 23635, 17, 2719, 21515, 10679, 1922, 1920, 2311, 1927, 7977, 45, 30, 2442, 1033, 3]}, "items": [{"id": "p_1640", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1641", "content": "hemolytic anemia [SEP] Management strategies for ribavirin-induced hemolytic anemia in the treatment of hepatitis C: clinical and economic implicat", "tokenized_content": [2, 21515, 10679, 3, 4280, 4762, 1958, 23635, 17, 2719, 21515, 10679, 1922, 1920, 2311, 1927, 7977, 45, 30, 2535, 1930, 7029, 6313, 6102, 1031, 3]}, "items": [{"id": "p_1641", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_1642", "content": "hepatitis C [SEP] gies for ribavirin-induced hemolytic anemia in the treatment of hepatitis C: clinical and economic implications.", "tokenized_content": [2, 7977, 45, 3, 7217, 1918, 1958, 23635, 17, 2719, 21515, 10679, 1922, 1920, 2311, 1927, 7977, 45, 30, 2535, 1930, 7029, 7020, 18, 3]}, "items": [{"id": "p_1642", "content": "Hepatitis C [SEP] INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 day", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 7977, 45, 3413, 16, 43, 2957, 17, 10338, 3146, 3413, 18, 2496, 5282, 3047, 1977, 2627, 17, 3865, 3007, 3]}]}
{"query": {"id": "q_1643", "content": "ribavirin [SEP] fectiveness of combination therapy with interferon and alpha-2b/ribavirin compared with interferon-alpha monotherapy in the treatment of ", "tokenized_content": [2, 23635, 3, 16688, 24770, 1927, 3921, 3181, 1956, 10001, 1930, 4595, 17, 5751, 19, 23635, 2452, 1956, 10001, 17, 4595, 13767, 1922, 1920, 2311, 1927, 3]}, "items": [{"id": "p_1643", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1644", "content": "interferon-alpha [SEP] on therapy with interferon and alpha-2b/ribavirin compared with interferon-alpha monotherapy in the treatment of chronic hepatitis C (CHC). Comb", "tokenized_content": [2, 10001, 17, 4595, 3, 1990, 3181, 1956, 10001, 1930, 4595, 17, 5751, 19, 23635, 2452, 1956, 10001, 17, 4595, 13767, 1922, 1920, 2311, 1927, 3724, 7977, 45, 12, 25009, 13, 3]}, "items": [{"id": "p_1644", "content": "Interferon-alpha [SEP] One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity", "score": 1, "type": null, "tokenized_content": [2, 10001, 17, 4595, 3, 2340, 1927, 1920, 2601, 51, 10001, 1036, 4152, 2007, 5009, 2877, 12257, 2014, 3541, 7439, 2642, 2094, 18, 1922, 2459, 1942, 10129, 2455, 3]}]}
{"query": {"id": "q_1645", "content": "chronic hepatitis C [SEP]  compared with interferon-alpha monotherapy in the treatment of chronic hepatitis C (CHC). Combination therapy is associated with a clinically impo", "tokenized_content": [2, 3724, 7977, 45, 3, 2452, 1956, 10001, 17, 4595, 13767, 1922, 1920, 2311, 1927, 3724, 7977, 45, 12, 25009, 13, 18, 3921, 3181, 1977, 2458, 1956, 43, 5908, 2754, 1037, 3]}, "items": [{"id": "p_1645", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1646", "content": "CHC [SEP] eron-alpha monotherapy in the treatment of chronic hepatitis C (CHC). Combination therapy is associated with a clinically important", "tokenized_content": [2, 25009, 3, 2668, 1916, 17, 4595, 13767, 1922, 1920, 2311, 1927, 3724, 7977, 45, 12, 25009, 13, 18, 3921, 3181, 1977, 2458, 1956, 43, 5908, 2715, 3]}, "items": [{"id": "p_1646", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1647", "content": "hemolytic anemia [SEP] d with a clinically important adverse effect: ribavirin-induced hemolytic anemia (RIHA). The objective of this study was to evaluate the direct ", "tokenized_content": [2, 21515, 10679, 3, 46, 1956, 43, 5908, 2715, 5246, 2495, 30, 23635, 17, 2719, 21515, 10679, 12, 11280, 2722, 13, 18, 1920, 4470, 1927, 2052, 2161, 1982, 1942, 4323, 1920, 3]}, "items": [{"id": "p_1647", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_1648", "content": "RIHA [SEP] y important adverse effect: ribavirin-induced hemolytic anemia (RIHA). The objective of this study was to evaluate the direct health", "tokenized_content": [2, 11280, 2722, 3, 67, 2715, 5246, 2495, 30, 23635, 17, 2719, 21515, 10679, 12, 11280, 2722, 13, 18, 1920, 4470, 1927, 2052, 2161, 1982, 1942, 4323, 1920, 3083, 2436, 3]}, "items": [{"id": "p_1648", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_1649", "content": "amine [SEP] Effects of amine pretreatment on ketamine catatonia in pinealectomized or hypoph", "tokenized_content": [2, 13610, 3, 2564, 1927, 13610, 9111, 1990, 14049, 3115, 8286, 10306, 1922, 27719, 18534, 2014, 26497, 1023, 3]}, "items": [{"id": "p_1649", "content": "Amines [SEP] A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dic", "score": 1, "type": null, "tokenized_content": [2, 20739, 3, 43, 2210, 1927, 4300, 3595, 2037, 14880, 2007, 26276, 6805, 12467, 1958, 1920, 6201, 1036, 18, 12, 2037, 6216, 10, 2118, 12940, 1023, 11, 61, 4399, 9192, 3]}]}
{"query": {"id": "q_1650", "content": "ketamine [SEP] Effects of amine pretreatment on ketamine catatonia in pinealectomized or hypophysectomized animals.", "tokenized_content": [2, 14049, 3, 2564, 1927, 13610, 9111, 1990, 14049, 3115, 8286, 10306, 1922, 27719, 18534, 2014, 26497, 30338, 4127, 2341, 1947, 2301, 3555, 18, 3]}, "items": [{"id": "p_1650", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_1651", "content": "catatonia [SEP] Effects of amine pretreatment on ketamine catatonia in pinealectomized or hypophysectomized animals.", "tokenized_content": [2, 3115, 8286, 10306, 3, 2564, 1927, 13610, 9111, 1990, 14049, 3115, 8286, 10306, 1922, 27719, 18534, 2014, 26497, 30338, 4127, 2341, 1947, 2301, 3555, 18, 3]}, "items": [{"id": "p_1651", "content": "Catatonia [SEP] A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (ac", "score": 1, "type": null, "tokenized_content": [2, 3115, 8286, 10306, 3, 43, 19305, 4770, 4378, 2007, 2340, 2014, 2253, 1927, 1920, 2894, 4415, 4075, 30, 26546, 16, 2446, 2421, 16, 2922, 1968, 7400, 1035, 12, 2000, 3]}]}
{"query": {"id": "q_1652", "content": "catecholamines [SEP] The present studies were designed to clarify the role of catecholamines and pineal idolamines on ketamine-induced catatonia in the inta", "tokenized_content": [2, 25923, 3, 1920, 2481, 2351, 1985, 4609, 1942, 11012, 1920, 2770, 1927, 25923, 1930, 27719, 23783, 10082, 2613, 1990, 14049, 17, 2719, 3115, 8286, 10306, 1922, 1920, 2218, 1019, 3]}, "items": [{"id": "p_1652", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_1653", "content": "ketamine [SEP]  to clarify the role of catecholamines and pineal idolamines on ketamine-induced catatonia in the intact, pinealectomized or hypophysect", "tokenized_content": [2, 14049, 3, 1942, 11012, 1920, 2770, 1927, 25923, 1930, 27719, 23783, 10082, 2613, 1990, 14049, 17, 2719, 3115, 8286, 10306, 1922, 1920, 6718, 16, 27719, 18534, 2014, 26497, 30338, 4127, 3]}, "items": [{"id": "p_1653", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_1654", "content": "catatonia [SEP] ole of catecholamines and pineal idolamines on ketamine-induced catatonia in the intact, pinealectomized or hypophysectomized chick and r", "tokenized_content": [2, 3115, 8286, 10306, 3, 12188, 1927, 25923, 1930, 27719, 23783, 10082, 2613, 1990, 14049, 17, 2719, 3115, 8286, 10306, 1922, 1920, 6718, 16, 27719, 18534, 2014, 26497, 30338, 4127, 2341, 3]}, "items": [{"id": "p_1654", "content": "Catatonia [SEP] A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (ac", "score": 1, "type": null, "tokenized_content": [2, 3115, 8286, 10306, 3, 43, 19305, 4770, 4378, 2007, 2340, 2014, 2253, 1927, 1920, 2894, 4415, 4075, 30, 26546, 16, 2446, 2421, 16, 2922, 1968, 7400, 1035, 12, 2000, 3]}]}
{"query": {"id": "q_1655", "content": "dopamine [SEP]  chick and rat. In the pinealectomized chick, pretreatment with dopamine increased the duration of catatonia (DOC) after ketamine, but p", "tokenized_content": [2, 7964, 3, 8006, 1930, 3067, 18, 1922, 1920, 27719, 18534, 8006, 16, 9111, 1956, 7964, 2502, 1920, 4392, 1927, 3115, 8286, 10306, 12, 4289, 13, 2256, 14049, 16, 2308, 58, 3]}, "items": [{"id": "p_1655", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1656", "content": "norepinephrine [SEP] ration of catatonia (DOC) after ketamine, but pretreatment with norepinephrine did not. The pineal indolamines exhibited mixed actions. Seroto", "tokenized_content": [2, 16436, 3, 12488, 1927, 3115, 8286, 10306, 12, 4289, 13, 2256, 14049, 16, 2308, 9111, 1956, 16436, 2811, 2084, 18, 1920, 27719, 22164, 14286, 5065, 4985, 7728, 18, 9752, 1037, 3]}, "items": [{"id": "p_1656", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1657", "content": "Serotonin [SEP] phrine did not. The pineal indolamines exhibited mixed actions. Serotonin and N-acetyl serotonin which augmented ketamine DOC, did not do", "tokenized_content": [2, 11153, 3, 17252, 2053, 2811, 2084, 18, 1920, 27719, 22164, 14286, 5065, 4985, 7728, 18, 11153, 1930, 56, 17, 6894, 11153, 2154, 13553, 14049, 4289, 16, 2811, 2084, 2608, 3]}, "items": [{"id": "p_1657", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1658", "content": "N-acetyl serotonin [SEP] . The pineal indolamines exhibited mixed actions. Serotonin and N-acetyl serotonin which augmented ketamine DOC, did not do so in the absence of t", "tokenized_content": [2, 56, 17, 6894, 11153, 3, 18, 1920, 27719, 22164, 14286, 5065, 4985, 7728, 18, 11153, 1930, 56, 17, 6894, 11153, 2154, 13553, 14049, 4289, 16, 2811, 2084, 2608, 2577, 1922, 3]}, "items": [{"id": "p_1658", "content": "N-acetylserotonin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 6894, 13545, 11099, 8635, 1022, 3, 3]}]}
{"query": {"id": "q_1659", "content": "melatonin [SEP]  DOC, did not do so in the absence of the pineal gland, whereas melatonin potentiated the ketamine DOC in both the intact and pinealectom", "tokenized_content": [2, 13366, 3, 4289, 16, 2811, 2084, 2608, 2577, 1922, 1920, 3905, 1927, 1920, 27719, 8359, 16, 3417, 13366, 20419, 1920, 14049, 4289, 1922, 2321, 1920, 6718, 1930, 27719, 14503, 3]}, "items": [{"id": "p_1659", "content": "Melatonin [SEP] A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion incre", "score": 1, "type": null, "tokenized_content": [2, 13366, 3, 43, 24241, 19730, 13610, 1988, 1977, 2435, 1922, 3555, 1930, 4793, 18, 1922, 9902, 16, 13366, 1977, 4152, 2007, 1920, 27719, 8359, 18, 2496, 5512, 2203, 3]}]}
{"query": {"id": "q_1660", "content": "Ketamine [SEP]  the ketamine DOC in both the intact and pinealectomized chick. Ketamine was more potent in the hypophysectomized chick and the circadia", "tokenized_content": [2, 14049, 3, 1920, 14049, 4289, 1922, 2321, 1920, 6718, 1930, 27719, 18534, 8006, 18, 14049, 1982, 2253, 6828, 1922, 1920, 26497, 30338, 4127, 2341, 1947, 2301, 8006, 1930, 1920, 3624, 3]}, "items": [{"id": "p_1660", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_1661", "content": "amines [SEP] he present studies were designed to clarify the role of catecholamines and pineal idolamines on ketamine-induced catatonia in the inta", "tokenized_content": [2, 20739, 3, 2234, 2481, 2351, 1985, 4609, 1942, 11012, 1920, 2770, 1927, 25923, 1930, 27719, 23783, 10082, 2613, 1990, 14049, 17, 2719, 3115, 8286, 10306, 1922, 1920, 2218, 1019, 3]}, "items": [{"id": "p_1661", "content": "Amines [SEP] A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dic", "score": 1, "type": null, "tokenized_content": [2, 20739, 3, 43, 2210, 1927, 4300, 3595, 2037, 14880, 2007, 26276, 6805, 12467, 1958, 1920, 6201, 1036, 18, 12, 2037, 6216, 10, 2118, 12940, 1023, 11, 61, 4399, 9192, 3]}]}
{"query": {"id": "q_1662", "content": "azelastine [SEP] nd, multiple-dose, parallel-groups efficacy and safety trial of azelastine, chlorpheniramine, and placebo in the treatment of spring aller", "tokenized_content": [2, 6352, 15208, 2156, 2053, 3, 8026, 16, 3137, 17, 3253, 16, 6110, 17, 2671, 4348, 1930, 5407, 3046, 1927, 6352, 15208, 2156, 2053, 16, 4891, 17616, 11979, 25157, 16, 1930, 3]}, "items": [{"id": "p_1662", "content": "azelastine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6352, 15208, 2156, 2053, 3, 3]}]}
{"query": {"id": "q_1663", "content": "chlorpheniramine [SEP] -dose, parallel-groups efficacy and safety trial of azelastine, chlorpheniramine, and placebo in the treatment of spring allergic rhinitis.", "tokenized_content": [2, 4891, 17616, 11979, 25157, 3, 17, 3253, 16, 6110, 17, 2671, 4348, 1930, 5407, 3046, 1927, 6352, 15208, 2156, 2053, 16, 4891, 17616, 11979, 25157, 16, 1930, 5936, 1922, 1920, 3]}, "items": [{"id": "p_1663", "content": "Chlorpheniramine [SEP] A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veter", "score": 1, "type": null, "tokenized_content": [2, 4891, 17616, 11979, 25157, 3, 43, 14622, 9169, 8151, 2251, 1922, 10519, 5298, 16, 15568, 9087, 16, 21298, 16, 27986, 6148, 16, 1930, 6678, 18, 2176, 2258, 2222, 2252, 2251, 1922, 9956, 3]}]}
{"query": {"id": "q_1664", "content": "spring allergic rhinitis [SEP] f azelastine, chlorpheniramine, and placebo in the treatment of spring allergic rhinitis.", "tokenized_content": [2, 11858, 10519, 21298, 3, 48, 6352, 15208, 2156, 2053, 16, 4891, 17616, 11979, 25157, 16, 1930, 5936, 1922, 1920, 2311, 1927, 11858, 10519, 21298, 18, 3]}, "items": [{"id": "p_1664", "content": "Rhinitis, Allergic, Seasonal [SEP] Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCH", "score": 1, "type": null, "tokenized_content": [2, 21298, 16, 10519, 16, 10995, 3, 10519, 21298, 1988, 5110, 2019, 1920, 2841, 2367, 4808, 2476, 18, 2176, 1977, 4378, 2007, 3939, 16911, 3678, 1956, 26919, 12874, 1929, 1930, 20687, 3]}]}
{"query": {"id": "q_1665", "content": "Azelastine [SEP] Azelastine, a novel antiallergic medication, was compared with chlorphenir", "tokenized_content": [2, 6352, 15208, 2156, 2053, 3, 6352, 15208, 2156, 2053, 16, 43, 4008, 2246, 2214, 5237, 6093, 16, 1982, 2452, 1956, 4891, 17616, 1996, 3]}, "items": [{"id": "p_1665", "content": "azelastine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6352, 15208, 2156, 2053, 3, 3]}]}
{"query": {"id": "q_1666", "content": "chlorpheniramine maleate [SEP] Azelastine, a novel antiallergic medication, was compared with chlorpheniramine maleate and placebo for efficacy and safety in the treatment of spring ", "tokenized_content": [2, 4891, 17616, 11979, 25157, 4005, 2010, 3, 6352, 15208, 2156, 2053, 16, 43, 4008, 2246, 2214, 5237, 6093, 16, 1982, 2452, 1956, 4891, 17616, 11979, 25157, 4005, 2010, 1930, 5936, 3]}, "items": [{"id": "p_1666", "content": "Chlorpheniramine [SEP] A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veter", "score": 1, "type": null, "tokenized_content": [2, 4891, 17616, 11979, 25157, 3, 43, 14622, 9169, 8151, 2251, 1922, 10519, 5298, 16, 15568, 9087, 16, 21298, 16, 27986, 6148, 16, 1930, 6678, 18, 2176, 2258, 2222, 2252, 2251, 1922, 9956, 3]}]}
{"query": {"id": "q_1667", "content": "spring allergic rhinitis [SEP] maleate and placebo for efficacy and safety in the treatment of spring allergic rhinitis in a multicenter, double-blind, multiple-dose, parallel-groups ", "tokenized_content": [2, 11858, 10519, 21298, 3, 4005, 2010, 1930, 5936, 1958, 4348, 1930, 5407, 1922, 1920, 2311, 1927, 11858, 10519, 21298, 1922, 43, 14620, 16, 4825, 17, 7109, 16, 3137, 17, 3253, 3]}, "items": [{"id": "p_1667", "content": "Rhinitis, Allergic, Seasonal [SEP] Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCH", "score": 1, "type": null, "tokenized_content": [2, 21298, 16, 10519, 16, 10995, 3, 10519, 21298, 1988, 5110, 2019, 1920, 2841, 2367, 4808, 2476, 18, 2176, 1977, 4378, 2007, 3939, 16911, 3678, 1956, 26919, 12874, 1929, 1930, 20687, 3]}]}
{"query": {"id": "q_1668", "content": "azelastine [SEP] ing aeroallergens. Medications were given four times daily; the azelastine groups received 0.5, 1.0, or 2.0 mg in the morning and evening ", "tokenized_content": [2, 6352, 15208, 2156, 2053, 3, 30393, 6049, 20827, 3823, 7470, 18, 7719, 1985, 3258, 3006, 3586, 4692, 31, 1920, 6352, 15208, 2156, 2053, 2671, 4004, 20, 18, 25, 16, 21, 3]}, "items": [{"id": "p_1668", "content": "azelastine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6352, 15208, 2156, 2053, 3, 3]}]}
{"query": {"id": "q_1669", "content": "chlorpheniramine [SEP] Azelastine, a novel antiallergic medication, was compared with chlorpheniramine maleate and placebo for efficacy and safety in the treatment of", "tokenized_content": [2, 4891, 17616, 11979, 25157, 3, 6352, 15208, 2156, 2053, 16, 43, 4008, 2246, 2214, 5237, 6093, 16, 1982, 2452, 1956, 4891, 17616, 11979, 25157, 4005, 2010, 1930, 5936, 1958, 4348, 3]}, "items": [{"id": "p_1669", "content": "Chlorpheniramine [SEP] A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veter", "score": 1, "type": null, "tokenized_content": [2, 4891, 17616, 11979, 25157, 3, 43, 14622, 9169, 8151, 2251, 1922, 10519, 5298, 16, 15568, 9087, 16, 21298, 16, 27986, 6148, 16, 1930, 6678, 18, 2176, 2258, 2222, 2252, 2251, 1922, 9956, 3]}]}
{"query": {"id": "q_1670", "content": "Drowsiness [SEP] re were no serious side effects in any of the treatment groups. Drowsiness and altered taste perception were increased significantly over ", "tokenized_content": [2, 29247, 6777, 1979, 3, 1964, 1985, 2239, 7433, 4159, 2564, 1922, 2967, 1927, 1920, 2311, 2671, 18, 29247, 6777, 1979, 1930, 5520, 13891, 6262, 1985, 2502, 2567, 2338, 3]}, "items": [{"id": "p_1670", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_1671", "content": "altered taste perception [SEP] ous side effects in any of the treatment groups. Drowsiness and altered taste perception were increased significantly over placebo only in the high-dose", "tokenized_content": [2, 5520, 13891, 6262, 3, 17208, 1036, 4159, 2564, 1922, 2967, 1927, 1920, 2311, 2671, 18, 29247, 6777, 1979, 1930, 5520, 13891, 6262, 1985, 2502, 2567, 2338, 5936, 2444, 1922, 1920, 3]}, "items": [{"id": "p_1671", "content": "Taste Disorders [SEP] Conditions characterized by an alteration in gustatory function or perception. Taste disorders are frequently associated with OL", "score": 1, "type": null, "tokenized_content": [2, 13891, 4414, 3, 2961, 4378, 2007, 1925, 10076, 1922, 26416, 2548, 2347, 2014, 6262, 18, 13891, 4414, 2032, 5467, 2458, 1956, 2865, 3]}]}
{"query": {"id": "q_1672", "content": "seasonal allergic rhinitis [SEP] up. Azelastine appears to be a safe, efficacious medication for seasonal allergic rhinitis.", "tokenized_content": [2, 10995, 10519, 21298, 3, 2353, 18, 6352, 15208, 2156, 2053, 5107, 1942, 1998, 43, 7672, 16, 15860, 6093, 1958, 10995, 10519, 21298, 18, 3]}, "items": [{"id": "p_1672", "content": "Rhinitis, Allergic, Seasonal [SEP] Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCH", "score": 1, "type": null, "tokenized_content": [2, 21298, 16, 10519, 16, 10995, 3, 10519, 21298, 1988, 5110, 2019, 1920, 2841, 2367, 4808, 2476, 18, 2176, 1977, 4378, 2007, 3939, 16911, 3678, 1956, 26919, 12874, 1929, 1930, 20687, 3]}]}
{"query": {"id": "q_1673", "content": "hypercalcaemia [SEP] One case of acute hypercalcaemia and two of recurrent nephrolithiasis are reported in patients w", "tokenized_content": [2, 25374, 19101, 3, 2340, 3087, 1927, 3939, 25374, 19101, 1930, 2288, 1927, 7457, 7737, 2226, 29016, 2032, 2568, 1922, 2132, 65, 3]}, "items": [{"id": "p_1673", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1674", "content": "nephrolithiasis [SEP] One case of acute hypercalcaemia and two of recurrent nephrolithiasis are reported in patients who had regularly consumed large amoun", "tokenized_content": [2, 7737, 2226, 29016, 3, 2340, 3087, 1927, 3939, 25374, 19101, 1930, 2288, 1927, 7457, 7737, 2226, 29016, 2032, 2568, 1922, 2132, 2746, 2430, 13487, 10848, 3103, 2150, 2125, 3]}, "items": [{"id": "p_1674", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_1675", "content": "calcium carbon-ate [SEP] eported in patients who had regularly consumed large amounts of calcium carbon-ate-sodium bicarbonate powders for more than 20 years. The powders ", "tokenized_content": [2, 5016, 5056, 17, 30280, 3, 15751, 7446, 1919, 1922, 2132, 2746, 2430, 13487, 10848, 3103, 6222, 1927, 5016, 5056, 17, 30280, 17, 5227, 16106, 25019, 1958, 2253, 2254, 2036, 2739, 3]}, "items": [{"id": "p_1675", "content": "Calcium Carbonate [SEP] Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically a", "score": 1, "type": null, "tokenized_content": [2, 5016, 17724, 3, 5056, 1935, 2687, 5016, 7012, 12, 19107, 1010, 13, 18, 1925, 12685, 5427, 16, 13891, 5427, 10201, 2014, 6561, 1988, 5110, 1922, 4899, 18, 2176, 1977, 2251, 25058, 43, 3]}]}
{"query": {"id": "q_1676", "content": "sodium bicarbonate [SEP]  who had regularly consumed large amounts of calcium carbon-ate-sodium bicarbonate powders for more than 20 years. The powders had been obtained f", "tokenized_content": [2, 5227, 16106, 3, 2746, 2430, 13487, 10848, 3103, 6222, 1927, 5016, 5056, 17, 30280, 17, 5227, 16106, 25019, 1958, 2253, 2254, 2036, 2739, 18, 1920, 25019, 2430, 2252, 2926, 48, 3]}, "items": [{"id": "p_1676", "content": "Sodium Bicarbonate [SEP] A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in", "score": 1, "type": null, "tokenized_content": [2, 5227, 16106, 3, 43, 4511, 16, 14631, 10201, 1988, 1977, 5384, 2251, 1966, 43, 2087, 23811, 5899, 16, 1925, 15428, 24549, 14682, 16, 5510, 25178, 14151, 1930, 1922, 3]}]}
{"query": {"id": "q_1677", "content": "paralysis [SEP] Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and cortic", "tokenized_content": [2, 18973, 3, 7171, 18973, 2810, 1942, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 1930, 8106, 3]}, "items": [{"id": "p_1677", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_1678", "content": "nondepolarizing neuromuscular blocking agents [SEP] Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and corticosteroids.", "tokenized_content": [2, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 3, 7171, 18973, 2810, 1942, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 1930, 14610, 18, 3]}, "items": [{"id": "p_1678", "content": "Neuromuscular Nondepolarizing Agents [SEP] Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. ", "score": 1, "type": null, "tokenized_content": [2, 15829, 13125, 2128, 4362, 3903, 4820, 3, 4195, 1988, 12151, 2410, 5303, 2019, 1920, 7345, 15829, 6910, 2979, 7538, 14030, 1927, 1920, 4842, 2482, 5500, 18, 3]}]}
{"query": {"id": "q_1679", "content": "corticosteroids [SEP] alysis due to nondepolarizing neuromuscular blocking agents and corticosteroids.", "tokenized_content": [2, 14610, 3, 1969, 4662, 2810, 1942, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 1930, 14610, 18, 3]}, "items": [{"id": "p_1679", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_1680", "content": "nondepolarizing neuromuscular blocking agents [SEP] The long-term use of nondepolarizing neuromuscular blocking agents (ND-NMBA) has recently been implicated as a cause of prolonged ", "tokenized_content": [2, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 3, 1920, 2815, 17, 2576, 2485, 1927, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 12, 8026, 17, 2943, 7972, 13, 2258, 3998, 2252, 3]}, "items": [{"id": "p_1680", "content": "Neuromuscular Nondepolarizing Agents [SEP] Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. ", "score": 1, "type": null, "tokenized_content": [2, 15829, 13125, 2128, 4362, 3903, 4820, 3, 4195, 1988, 12151, 2410, 5303, 2019, 1920, 7345, 15829, 6910, 2979, 7538, 14030, 1927, 1920, 4842, 2482, 5500, 18, 3]}]}
{"query": {"id": "q_1681", "content": "ND-NMBA [SEP] long-term use of nondepolarizing neuromuscular blocking agents (ND-NMBA) has recently been implicated as a cause of prolonged muscle we", "tokenized_content": [2, 8026, 17, 2943, 7972, 3, 2815, 17, 2576, 2485, 1927, 13125, 2128, 4362, 3903, 15829, 7472, 4820, 12, 8026, 17, 2943, 7972, 13, 2258, 3998, 2252, 6835, 1966, 43, 3936, 3]}, "items": [{"id": "p_1681", "content": "Neuromuscular Nondepolarizing Agents [SEP] Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. ", "score": 1, "type": null, "tokenized_content": [2, 15829, 13125, 2128, 4362, 3903, 4820, 3, 4195, 1988, 12151, 2410, 5303, 2019, 1920, 7345, 15829, 6910, 2979, 7538, 14030, 1927, 1920, 4842, 2482, 5500, 18, 3]}]}
{"query": {"id": "q_1682", "content": "muscle weakness [SEP]  (ND-NMBA) has recently been implicated as a cause of prolonged muscle weakness, although the site of the lesion and the predisposing factors h", "tokenized_content": [2, 3760, 12175, 3, 12, 8026, 17, 2943, 7972, 13, 2258, 3998, 2252, 6835, 1966, 43, 3936, 1927, 7171, 3760, 12175, 16, 2876, 1920, 3200, 1927, 1920, 5709, 1930, 1920, 20908, 3]}, "items": [{"id": "p_1682", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_1683", "content": "respiratory insufficiency [SEP] been unclear. We report 3 patients (age 37-52 years) with acute respiratory insufficiency who developed prolonged weakness following the discontinuation ", "tokenized_content": [2, 5481, 14566, 3, 2252, 6390, 18, 2038, 3809, 23, 2132, 12, 2632, 3191, 17, 4764, 2739, 13, 1956, 3939, 5481, 14566, 2746, 3530, 7171, 12175, 2894, 1920, 14775, 3]}, "items": [{"id": "p_1683", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_1684", "content": "weakness [SEP] BA) has recently been implicated as a cause of prolonged muscle weakness, although the site of the lesion and the predisposing factors h", "tokenized_content": [2, 12175, 3, 6813, 13, 2258, 3998, 2252, 6835, 1966, 43, 3936, 1927, 7171, 3760, 12175, 16, 2876, 1920, 3200, 1927, 1920, 5709, 1930, 1920, 20908, 2790, 50, 3]}, "items": [{"id": "p_1684", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_1685", "content": "ND-NMBAs [SEP] o developed prolonged weakness following the discontinuation of ND-NMBAs. Two patients also received intravenous corticosteroids. Renal ", "tokenized_content": [2, 8026, 17, 2943, 7972, 1036, 3, 57, 3530, 7171, 12175, 2894, 1920, 14775, 1927, 8026, 17, 2943, 7972, 1036, 18, 2288, 2132, 2222, 4004, 7307, 14610, 18, 4604, 3]}, "items": [{"id": "p_1685", "content": "Neuromuscular Nondepolarizing Agents [SEP] Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. ", "score": 1, "type": null, "tokenized_content": [2, 15829, 13125, 2128, 4362, 3903, 4820, 3, 4195, 1988, 12151, 2410, 5303, 2019, 1920, 7345, 15829, 6910, 2979, 7538, 14030, 1927, 1920, 4842, 2482, 5500, 18, 3]}]}
{"query": {"id": "q_1686", "content": "corticosteroids [SEP] ontinuation of ND-NMBAs. Two patients also received intravenous corticosteroids. Renal function was normal but hepatic function was impaired in", "tokenized_content": [2, 14610, 3, 9056, 1921, 10874, 1927, 8026, 17, 2943, 7972, 1036, 18, 2288, 2132, 2222, 4004, 7307, 14610, 18, 4604, 2347, 1982, 2791, 2308, 6095, 2347, 1982, 5761, 1922, 3]}, "items": [{"id": "p_1686", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_1687", "content": "acidosis [SEP]  but hepatic function was impaired in all patients, and all had acidosis. Electrophysiologic studies revealed low amplitude compound mot", "tokenized_content": [2, 19051, 3, 2308, 6095, 2347, 1982, 5761, 1922, 2136, 2132, 16, 1930, 2136, 2430, 19051, 18, 11350, 12649, 2351, 3404, 2330, 6531, 3547, 12798, 3]}, "items": [{"id": "p_1687", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_1688", "content": "vecuronium [SEP]  at 2 Hz showed a decremental response in 2 patients. The serum vecuronium level measured in 1 patient 14 days after the drug had been dis", "tokenized_content": [2, 28054, 10366, 2457, 3, 2019, 22, 4865, 2594, 43, 2649, 9600, 2644, 1922, 22, 2132, 18, 1920, 3256, 28054, 10366, 2457, 2237, 3045, 1922, 21, 2774, 2607, 3000, 2256, 1920, 3]}, "items": [{"id": "p_1688", "content": "Vecuronium Bromide [SEP] Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than panc", "score": 1, "type": null, "tokenized_content": [2, 28054, 10366, 2457, 13788, 3, 8914, 28273, 1915, 14203, 5928, 1927, 5001, 10366, 2457, 18, 43, 2447, 17, 24999, 15829, 7472, 5899, 1956, 7310, 4392, 1927, 4615, 2254, 5001, 3]}]}
{"query": {"id": "q_1689", "content": "loss of thick, myosin filaments [SEP] continued was 172 ng/mL. A muscle biopsy in this patient showed loss of thick, myosin filaments. The weakness in these patients is due to pathology at both the", "tokenized_content": [2, 3257, 1927, 4721, 16, 10863, 11855, 3, 7583, 1982, 15807, 4375, 19, 2646, 18, 43, 3760, 6831, 1922, 2052, 2774, 2594, 3257, 1927, 4721, 16, 10863, 11855, 18, 1920, 12175, 3]}, "items": [{"id": "p_1689", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1690", "content": "pathology at both the neuromuscular junction [SEP] ick, myosin filaments. The weakness in these patients is due to pathology at both the neuromuscular junction (most likely due to ND-NMBA) and muscle (most likely due to cor", "tokenized_content": [2, 6819, 2019, 2321, 1920, 15829, 6910, 3, 3996, 1040, 16, 10863, 11855, 18, 1920, 12175, 1922, 2144, 2132, 1977, 2810, 1942, 6819, 2019, 2321, 1920, 15829, 6910, 12, 2501, 3205, 3]}, "items": [{"id": "p_1690", "content": "Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif", "score": 1, "type": null, "tokenized_content": [2, 15829, 3902, 3, 43, 3335, 2576, 17527, 2826, 4842, 7428, 2573, 31, 5009, 7580, 2433, 3902, 31, 1930, 4908, 12330, 3902, 18, 6747, 3]}]}
{"query": {"id": "q_1691", "content": "Hepatic dysfunction [SEP] ue to ND-NMBA) and muscle (most likely due to corticosteroids). Hepatic dysfunction and acidosis are contributing risk factors.", "tokenized_content": [2, 6095, 5273, 3, 63, 1021, 1942, 8026, 17, 2943, 7972, 13, 1930, 3760, 12, 2501, 3205, 2810, 1942, 14610, 13, 18, 6095, 5273, 1930, 19051, 2032, 8739, 2565, 2790, 18, 3]}, "items": [{"id": "p_1691", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_1692", "content": "Prostaglandin E2 [SEP] Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involv", "tokenized_content": [2, 15900, 6602, 3, 15900, 6602, 17, 2719, 7821, 15534, 1922, 2791, 16, 11993, 3615, 30, 2755, 1020, 3]}, "items": [{"id": "p_1692", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_1693", "content": "bladder hyperactivity [SEP] Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involvement of tachykinins?", "tokenized_content": [2, 7821, 15534, 3, 15900, 6602, 17, 2719, 7821, 15534, 1922, 2791, 16, 11993, 3615, 30, 5668, 1927, 12762, 23674, 15020, 1036, 35, 3]}, "items": [{"id": "p_1693", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_1694", "content": "tachykinins [SEP] bladder hyperactivity in normal, conscious rats: involvement of tachykinins?", "tokenized_content": [2, 12762, 23674, 15020, 1036, 3, 7821, 15534, 1922, 2791, 16, 11993, 3615, 30, 5668, 1927, 12762, 23674, 15020, 1036, 35, 3]}, "items": [{"id": "p_1694", "content": "Tachykinins [SEP] A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is eith", "score": 1, "type": null, "tokenized_content": [2, 12762, 23674, 15020, 1036, 3, 43, 3416, 1927, 12186, 3500, 5320, 10763, 43, 3059, 5305, 45, 17, 4262, 3244, 16, 17, 10422, 17, 66, 17, 3376, 17, 10632, 17, 2130, 17, 15410, 16, 2597, 66, 1977, 16101, 1963, 3]}]}
{"query": {"id": "q_1695", "content": "prostaglandin (PG) E2 [SEP] investigated by continuous cystometry, intravesically instilled prostaglandin (PG) E2 facilitated micturition and increased basal intravesical pressu", "tokenized_content": [2, 15900, 12, 5306, 13, 6602, 3, 3845, 2007, 4798, 9446, 5014, 16, 6306, 18522, 5657, 1954, 4766, 6297, 15900, 12, 5306, 13, 6602, 11556, 2206, 1031, 25682, 1930, 2502, 5342, 3]}, "items": [{"id": "p_1695", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_1696", "content": "RP 67,580 [SEP] ct was attenuated by both the NK1 receptor selective antagonist RP 67,580 and the NK2 receptor selective antagonist SR 48,968, given intr", "tokenized_content": [2, 4822, 4838, 16, 25195, 3, 3369, 1982, 8060, 2007, 2321, 1920, 25320, 3148, 5328, 8151, 4822, 4838, 16, 25195, 1930, 1920, 5916, 1028, 3148, 5328, 8151, 4581, 3427, 16, 4746, 3]}, "items": [{"id": "p_1696", "content": "7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 27, 16, 27, 17, 18190, 17, 22, 17, 12, 21, 17, 2042, 3522, 17, 22, 17, 12, 22, 17, 17954, 17616, 2199, 13, 7843, 13, 7990, 2584, 1931, 23854, 2762, 1945, 17, 24, 17, 2340, 3, 3]}]}
{"query": {"id": "q_1697", "content": "SR 48,968 [SEP]  antagonist RP 67,580 and the NK2 receptor selective antagonist SR 48,968, given intra-arterially, suggesting that it was mediated by sti", "tokenized_content": [2, 4581, 3427, 16, 4746, 1025, 3, 8151, 4822, 4838, 16, 25195, 1930, 1920, 5916, 1028, 3148, 5328, 8151, 4581, 3427, 16, 4746, 1025, 16, 3258, 5153, 17, 6624, 1954, 16, 3]}, "items": [{"id": "p_1697", "content": "SR 48968 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4581, 3427, 10352, 1025, 3, 3]}]}
{"query": {"id": "q_1698", "content": "PGE2 [SEP] imulation of both NK1 and NK2 receptors. Intra-arterially given PGE2 produced a distinct increase in bladder pressure before initiat", "tokenized_content": [2, 13790, 3, 2042, 2281, 1927, 2321, 25320, 1930, 5916, 1028, 4086, 18, 5153, 17, 6624, 1954, 3258, 13790, 4152, 43, 4493, 2760, 1922, 7821, 3772, 3119, 2907, 1926, 3]}, "items": [{"id": "p_1698", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_1699", "content": "PG [SEP]  continuous cystometry, intravesically instilled prostaglandin (PG) E2 facilitated micturition and increased basal intravesical pr", "tokenized_content": [2, 5306, 3, 4798, 9446, 5014, 16, 6306, 18522, 5657, 1954, 4766, 6297, 15900, 12, 5306, 13, 6602, 11556, 2206, 1031, 25682, 1930, 2502, 5342, 6306, 18522, 5657, 2033, 3]}, "items": [{"id": "p_1699", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1700", "content": "tachykinins [SEP] ven intravesically, PGE2 may stimulate micturition by releasing tachykinins from nerves in and/or immediately below the urothelium. These t", "tokenized_content": [2, 12762, 23674, 15020, 1036, 3, 8102, 6306, 18522, 5657, 1954, 16, 13790, 2278, 9084, 2206, 1031, 25682, 2007, 13182, 12762, 23674, 15020, 1036, 2037, 12014, 1922, 1930, 19, 2014, 6183, 3]}, "items": [{"id": "p_1700", "content": "Tachykinins [SEP] A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is eith", "score": 1, "type": null, "tokenized_content": [2, 12762, 23674, 15020, 1036, 3, 43, 3416, 1927, 12186, 3500, 5320, 10763, 43, 3059, 5305, 45, 17, 4262, 3244, 16, 17, 10422, 17, 66, 17, 3376, 17, 10632, 17, 2130, 17, 15410, 16, 2597, 66, 1977, 16101, 1963, 3]}]}
{"query": {"id": "q_1701", "content": "Prostanoids [SEP] iate a micturition reflex by stimulating NK1 and NK2 receptors. Prostanoids may, via release of tachykinins, contribute to both urge and bl", "tokenized_content": [2, 4876, 9286, 3753, 3, 21006, 1021, 43, 2206, 1031, 25682, 11573, 2007, 9868, 25320, 1930, 5916, 1028, 4086, 18, 4876, 9286, 3753, 2278, 16, 3454, 4012, 1927, 12762, 23674, 15020, 3]}, "items": [{"id": "p_1701", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1702", "content": "bladder hyperactivity [SEP] ds may, via release of tachykinins, contribute to both urge and bladder hyperactivity seen in inflammatory conditions of the lower urinary tract.", "tokenized_content": [2, 7821, 15534, 3, 4473, 2278, 16, 3454, 4012, 1927, 12762, 23674, 15020, 1036, 16, 4672, 1942, 2321, 11460, 1021, 1930, 7821, 15534, 3945, 1922, 3769, 2961, 1927, 1920, 2826, 7075, 3]}, "items": [{"id": "p_1702", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_1703", "content": "Thiazide [SEP] Thiazide diuretics, hypokalemia and cardiac arrhythmias.", "tokenized_content": [2, 27225, 2261, 3, 27225, 2261, 25505, 16, 14395, 7640, 1952, 6026, 1930, 4435, 16934, 18, 3]}, "items": [{"id": "p_1703", "content": "Thiazides [SEP] Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SOD", "score": 1, "type": null, "tokenized_content": [2, 27225, 3726, 3, 27804, 13153, 4300, 1956, 12585, 1930, 6634, 1922, 1920, 6335, 18, 2052, 2576, 5384, 11238, 1942, 1920, 19225, 22523, 2713, 10119, 1036, 1988, 2875, 4546, 3]}]}
{"query": {"id": "q_1704", "content": "hypokalemia [SEP] Thiazide diuretics, hypokalemia and cardiac arrhythmias.", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 27225, 2261, 25505, 16, 14395, 7640, 1952, 6026, 1930, 4435, 16934, 18, 3]}, "items": [{"id": "p_1704", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1705", "content": "cardiac arrhythmias [SEP] Thiazide diuretics, hypokalemia and cardiac arrhythmias.", "tokenized_content": [2, 4435, 16934, 3, 27225, 2261, 25505, 16, 14395, 7640, 1952, 6026, 1930, 4435, 16934, 18, 3]}, "items": [{"id": "p_1705", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_1706", "content": "Thiazide [SEP] Thiazide diuretics are widely accepted as the cornerstone of antihyperte", "tokenized_content": [2, 27225, 2261, 3, 27225, 2261, 25505, 2032, 5673, 8131, 1966, 1920, 23153, 5405, 1021, 1927, 15759, 1021, 3]}, "items": [{"id": "p_1706", "content": "Thiazides [SEP] Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SOD", "score": 1, "type": null, "tokenized_content": [2, 27225, 3726, 3, 27804, 13153, 4300, 1956, 12585, 1930, 6634, 1922, 1920, 6335, 18, 2052, 2576, 5384, 11238, 1942, 1920, 19225, 22523, 2713, 10119, 1036, 1988, 2875, 4546, 3]}]}
{"query": {"id": "q_1707", "content": "Hypokalemia [SEP] pted as the cornerstone of antihypertensive treatment programs. Hypokalemia is a commonly encountered metabolic consequence of chronic thia", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 4401, 1919, 1966, 1920, 23153, 5405, 1021, 1927, 16439, 2311, 6144, 18, 14395, 7640, 1952, 6026, 1977, 43, 5384, 11989, 4487, 7749, 1927, 3724, 7566, 3]}, "items": [{"id": "p_1707", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1708", "content": "thiazide [SEP] emia is a commonly encountered metabolic consequence of chronic thiazide therapy. We treated 38 patients (22 low renin, 16 normal renin)", "tokenized_content": [2, 27225, 2261, 3, 2391, 2126, 1977, 43, 5384, 11989, 4487, 7749, 1927, 3724, 27225, 2261, 3181, 18, 2038, 2868, 3738, 2132, 12, 2950, 2330, 16306, 16, 2641, 2791, 16306, 13, 3]}, "items": [{"id": "p_1708", "content": "Thiazides [SEP] Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SOD", "score": 1, "type": null, "tokenized_content": [2, 27225, 3726, 3, 27804, 13153, 4300, 1956, 12585, 1930, 6634, 1922, 1920, 6335, 18, 2052, 2576, 5384, 11238, 1942, 1920, 19225, 22523, 2713, 10119, 1036, 1988, 2875, 4546, 3]}]}
{"query": {"id": "q_1709", "content": "diastolic hypertension [SEP] eated 38 patients (22 low renin, 16 normal renin) with moderate diastolic hypertension with hydrochlorothiazide (HCTC) administered on a twice daily s", "tokenized_content": [2, 9395, 5579, 3, 13619, 1919, 3738, 2132, 12, 2950, 2330, 16306, 16, 2641, 2791, 16306, 13, 1956, 5086, 9395, 5579, 1956, 14369, 30354, 2261, 12, 10745, 1030, 13, 5254, 1990, 3]}, "items": [{"id": "p_1709", "content": "Hypertension, Diastolic, Resistance to [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 9395, 16, 3554, 1942, 3, 3]}]}
{"query": {"id": "q_1710", "content": "hydrochlorothiazide [SEP] nin, 16 normal renin) with moderate diastolic hypertension with hydrochlorothiazide (HCTC) administered on a twice daily schedule. Initial dose was", "tokenized_content": [2, 14369, 30354, 2261, 3, 12117, 16, 2641, 2791, 16306, 13, 1956, 5086, 9395, 5579, 1956, 14369, 30354, 2261, 12, 10745, 1030, 13, 5254, 1990, 43, 6470, 4692, 11660, 18, 3754, 3]}, "items": [{"id": "p_1710", "content": "Hydrochlorothiazide [SEP] A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the", "score": 1, "type": null, "tokenized_content": [2, 14369, 30354, 2261, 3, 43, 27225, 2261, 26829, 3868, 3311, 1920, 29183, 7210, 1927, 2052, 2921, 18, 2176, 7268, 1920, 26287, 1927, 25308, 2037, 1920, 3]}]}
{"query": {"id": "q_1711", "content": "HCTC [SEP]  with moderate diastolic hypertension with hydrochlorothiazide (HCTC) administered on a twice daily schedule. Initial dose was 50 mg", "tokenized_content": [2, 10745, 1030, 3, 1956, 5086, 9395, 5579, 1956, 14369, 30354, 2261, 12, 10745, 1030, 13, 5254, 1990, 43, 6470, 4692, 11660, 18, 3754, 3253, 1982, 2761, 2786, 3]}, "items": [{"id": "p_1711", "content": "Hydrochlorothiazide [SEP] A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the", "score": 1, "type": null, "tokenized_content": [2, 14369, 30354, 2261, 3, 43, 27225, 2261, 26829, 3868, 3311, 1920, 29183, 7210, 1927, 2052, 2921, 18, 2176, 7268, 1920, 26287, 1927, 25308, 2037, 1920, 3]}]}
{"query": {"id": "q_1712", "content": "K [SEP]  mg and 200 mg daily until blood pressure normalized. The serum K during the control period was 4.5 +/- 0.2 mEq/l an on 50, 100, ", "tokenized_content": [2, 53, 3, 2786, 1930, 2191, 2786, 4692, 4801, 2877, 3772, 5766, 18, 1920, 3256, 53, 2409, 1920, 2285, 3047, 1982, 24, 18, 25, 15, 19, 17, 20, 18, 22, 25509, 3]}, "items": [{"id": "p_1712", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1713", "content": "HCTZ [SEP] trol period was 4.5 +/- 0.2 mEq/l an on 50, 100, 150 and 200 mg HCTZ daily 3.9 +/- 0.3, 3.4 +/- 0.2, 2.9 +/- 0.2, and 2.4 +/- 0.3 mE", "tokenized_content": [2, 10745, 1011, 3, 12730, 1024, 3047, 1982, 24, 18, 25, 15, 19, 17, 20, 18, 22, 25509, 19, 54, 1925, 1990, 2761, 16, 2813, 16, 5493, 1930, 2191, 2786, 10745, 3]}, "items": [{"id": "p_1713", "content": "Hydrochlorothiazide [SEP] A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the", "score": 1, "type": null, "tokenized_content": [2, 14369, 30354, 2261, 3, 43, 27225, 2261, 26829, 3868, 3311, 1920, 29183, 7210, 1927, 2052, 2921, 18, 2176, 7268, 1920, 26287, 1927, 25308, 2037, 1920, 3]}]}
{"query": {"id": "q_1714", "content": "hypokalemia [SEP] han 0.001. In conclusion we found that thiazide diuretics cause hypokalemia and depletion of body potassium. The more profound hypokalemia,", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 13087, 20, 18, 3472, 18, 1922, 4180, 2038, 2435, 1988, 27225, 2261, 25505, 3936, 14395, 7640, 1952, 6026, 1930, 6882, 1927, 3362, 9057, 18, 1920, 3]}, "items": [{"id": "p_1714", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1715", "content": "potassium [SEP] that thiazide diuretics cause hypokalemia and depletion of body potassium. The more profound hypokalemia, the greater the propensity for ", "tokenized_content": [2, 9057, 3, 1988, 27225, 2261, 25505, 3936, 14395, 7640, 1952, 6026, 1930, 6882, 1927, 3362, 9057, 18, 1920, 2253, 11098, 14395, 7640, 1952, 6026, 16, 1920, 3430, 1920, 12020, 1958, 3]}, "items": [{"id": "p_1715", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1716", "content": "potassium [SEP] Diuretics, potassium and arrhythmias in hypertensive coronary disease.", "tokenized_content": [2, 9057, 3, 25505, 16, 9057, 1930, 16934, 1922, 11706, 5846, 2573, 18, 3]}, "items": [{"id": "p_1716", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1717", "content": "arrhythmias [SEP] Diuretics, potassium and arrhythmias in hypertensive coronary disease.", "tokenized_content": [2, 16934, 3, 25505, 16, 9057, 1930, 16934, 1922, 11706, 5846, 2573, 18, 3]}, "items": [{"id": "p_1717", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_1718", "content": "hypertensive [SEP] Diuretics, potassium and arrhythmias in hypertensive coronary disease.", "tokenized_content": [2, 11706, 3, 25505, 16, 9057, 1930, 16934, 1922, 11706, 5846, 2573, 18, 3]}, "items": [{"id": "p_1718", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1719", "content": "coronary disease [SEP] Diuretics, potassium and arrhythmias in hypertensive coronary disease.", "tokenized_content": [2, 5846, 2573, 3, 25505, 16, 9057, 1930, 16934, 1922, 11706, 5846, 2573, 18, 3]}, "items": [{"id": "p_1719", "content": "Coronary Disease [SEP] An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow", "score": 1, "type": null, "tokenized_content": [2, 5846, 2573, 3, 1925, 14093, 2192, 6497, 3183, 8456, 1930, 1920, 4796, 1927, 1920, 5846, 7208, 1942, 9042, 5409, 2877, 3426, 3]}]}
{"query": {"id": "q_1720", "content": "potassium [SEP] It has been proposed that modest changes in plasma potassium can alter the tendency towards cardiac arrhythmias. If this wer", "tokenized_content": [2, 9057, 3, 2176, 2258, 2252, 4211, 1988, 9194, 2840, 1922, 3582, 9057, 2112, 4238, 1920, 10080, 5681, 4435, 16934, 18, 2647, 2052, 22210, 3]}, "items": [{"id": "p_1720", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1721", "content": "cardiac arrhythmias [SEP] dest changes in plasma potassium can alter the tendency towards cardiac arrhythmias. If this were so, patients with coronary artery disease might b", "tokenized_content": [2, 4435, 16934, 3, 10300, 2840, 1922, 3582, 9057, 2112, 4238, 1920, 10080, 5681, 4435, 16934, 18, 2647, 2052, 1985, 2577, 16, 2132, 1956, 5846, 5511, 2573, 3284, 44, 3]}, "items": [{"id": "p_1721", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_1722", "content": "coronary artery disease [SEP] ncy towards cardiac arrhythmias. If this were so, patients with coronary artery disease might be especially susceptible. Thus, myocardial electrical ex", "tokenized_content": [2, 5846, 5511, 2573, 3, 5301, 1012, 5681, 4435, 16934, 18, 2647, 2052, 1985, 2577, 16, 2132, 1956, 5846, 5511, 2573, 3284, 1998, 4369, 7819, 18, 2842, 16, 6497, 8287, 1975, 3]}, "items": [{"id": "p_1722", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_1723", "content": "hypertension [SEP] rical excitability was measured in patients with mild essential hypertension and known coronary artery disease after 8 weeks of treatment wi", "tokenized_content": [2, 5579, 3, 18091, 1923, 14670, 1982, 3045, 1922, 2132, 1956, 5809, 4415, 5579, 1930, 3171, 5846, 5511, 2573, 2256, 28, 3625, 1927, 2311, 11980, 3]}, "items": [{"id": "p_1723", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1724", "content": "amiloride [SEP] fter 8 weeks of treatment with a potassium-conserving diuretic (amiloride) and a similar period on a potassium-losing diuretic (chlorthal", "tokenized_content": [2, 30374, 29189, 3, 8916, 1915, 28, 3625, 1927, 2311, 1956, 43, 9057, 17, 7040, 1941, 26829, 12, 30374, 29189, 13, 1930, 43, 2551, 3047, 1990, 43, 9057, 17, 22107, 26829, 3]}, "items": [{"id": "p_1724", "content": "Amiloride [SEP] A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a ", "score": 1, "type": null, "tokenized_content": [2, 30374, 29189, 3, 43, 6487, 10119, 3547, 7918, 5227, 26287, 2596, 5227, 5628, 1922, 4604, 4944, 2094, 18, 2052, 3523, 15628, 43, 3]}]}
{"query": {"id": "q_1725", "content": "chlorthalidone [SEP] amiloride) and a similar period on a potassium-losing diuretic (chlorthalidone) in a randomised study. Plasma potassium concentrations were on", "tokenized_content": [2, 4891, 8025, 15726, 3, 30374, 29189, 13, 1930, 43, 2551, 3047, 1990, 43, 9057, 17, 22107, 26829, 12, 4891, 8025, 15726, 13, 1922, 43, 12090, 2161, 18, 3582, 9057, 3295, 3]}, "items": [{"id": "p_1725", "content": "Chlorthalidone [SEP] A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4891, 8025, 15726, 3, 43, 18536, 19028, 12502, 16408, 1021, 17, 19686, 29899, 1988, 7462, 4575, 9213, 4517, 1942, 43, 19225, 17616, 3965, 2386, 18, 2176, 1977, 3311, 43, 27225, 2261, 17, 3189, 26829, 18, 3]}]}
{"query": {"id": "q_1726", "content": "noradrenaline [SEP] e and volume states as assessed by bodyweight, plasma renin and noradrenaline (norepinephrine) concentrations were similar on the 2 regimens.", "tokenized_content": [2, 22636, 3, 47, 1930, 3776, 4376, 1966, 3683, 2007, 3362, 7987, 16, 3582, 16306, 1930, 22636, 12, 16436, 13, 3295, 1985, 2551, 1990, 1920, 22, 9922, 18, 3]}, "items": [{"id": "p_1726", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1727", "content": "norepinephrine [SEP] ates as assessed by bodyweight, plasma renin and noradrenaline (norepinephrine) concentrations were similar on the 2 regimens. Compared to ami", "tokenized_content": [2, 16436, 3, 30280, 1036, 1966, 3683, 2007, 3362, 7987, 16, 3582, 16306, 1930, 22636, 12, 16436, 13, 3295, 1985, 2551, 1990, 1920, 22, 9922, 18, 2452, 1942, 15665, 3]}, "items": [{"id": "p_1727", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1728", "content": "ventricular ectopic beats [SEP] orthalidone phase was associated with an increased frequency of ventricular ectopic beats (24-hour Holter monitoring) and a higher Lown grading, increase", "tokenized_content": [2, 6493, 11092, 19380, 3, 5561, 12498, 28615, 1021, 3193, 1982, 2458, 1956, 1925, 2502, 3528, 1927, 6493, 11092, 19380, 12, 2686, 17, 6231, 8001, 1967, 5378, 13, 1930, 43, 2580, 3]}, "items": [{"id": "p_1728", "content": "Ventricular Premature Complexes [SEP] A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS compl", "score": 1, "type": null, "tokenized_content": [2, 6493, 9839, 5048, 3, 43, 2601, 1927, 4435, 18346, 1956, 9839, 15465, 1927, 1920, 4003, 21008, 18, 2176, 1977, 4378, 2007, 1920, 9839, 22355, 6581, 3]}]}
{"query": {"id": "q_1729", "content": "ischaemic heart disease [SEP] an increase myocardial electrical excitability in patients with ischaemic heart disease, even minor falls in plasma potassium concentrations are probab", "tokenized_content": [2, 19855, 4003, 2573, 3, 1925, 2760, 6497, 8287, 14670, 1922, 2132, 1956, 19855, 4003, 2573, 16, 3385, 5857, 12182, 1922, 3582, 9057, 3295, 2032, 2680, 1993, 3]}, "items": [{"id": "p_1729", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_1730", "content": "GABA [SEP] GABA involvement in naloxone induced reversal of respiratory paralys", "tokenized_content": [2, 7992, 3, 7992, 5668, 1922, 21926, 2719, 12393, 1927, 5481, 11271, 2012, 3]}, "items": [{"id": "p_1730", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1731", "content": "naloxone [SEP] GABA involvement in naloxone induced reversal of respiratory paralysis produced by thiopenta", "tokenized_content": [2, 21926, 3, 7992, 5668, 1922, 21926, 2719, 12393, 1927, 5481, 18973, 4152, 2007, 15331, 17125, 3857, 3]}, "items": [{"id": "p_1731", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_1732", "content": "respiratory paralysis [SEP] GABA involvement in naloxone induced reversal of respiratory paralysis produced by thiopental.", "tokenized_content": [2, 5481, 18973, 3, 7992, 5668, 1922, 21926, 2719, 12393, 1927, 5481, 18973, 4152, 2007, 15331, 17125, 2381, 18, 3]}, "items": [{"id": "p_1732", "content": "Respiratory Paralysis [SEP] Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHER", "score": 1, "type": null, "tokenized_content": [2, 5481, 18973, 3, 4080, 2014, 4010, 12175, 1927, 1920, 7848, 1927, 11695, 18, 2052, 2625, 2278, 1998, 2458, 1956, 4842, 7428, 3902, 31, 4709, 3]}]}
{"query": {"id": "q_1733", "content": "thiopental [SEP]  naloxone induced reversal of respiratory paralysis produced by thiopental.", "tokenized_content": [2, 15331, 17125, 2381, 3, 21926, 2719, 12393, 1927, 5481, 18973, 4152, 2007, 15331, 17125, 2381, 18, 3]}, "items": [{"id": "p_1733", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_1734", "content": "respiratory paralysis [SEP] No agent is yet available to reverse respiratory paralysis produced by CNS depressants, such as general anesthetics. In th", "tokenized_content": [2, 5481, 18973, 3, 2239, 5899, 1977, 4898, 3322, 1942, 5267, 5481, 18973, 4152, 2007, 7520, 20852, 2356, 16, 2427, 1966, 3335, 25118, 18, 1922, 1913, 3]}, "items": [{"id": "p_1734", "content": "Respiratory Paralysis [SEP] Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHER", "score": 1, "type": null, "tokenized_content": [2, 5481, 18973, 3, 4080, 2014, 4010, 12175, 1927, 1920, 7848, 1927, 11695, 18, 2052, 2625, 2278, 1998, 2458, 1956, 4842, 7428, 3902, 31, 4709, 3]}]}
{"query": {"id": "q_1735", "content": "naloxone [SEP]  by CNS depressants, such as general anesthetics. In this study naloxone reversed respiratory paralysis induced by thiopental in rats. 2", "tokenized_content": [2, 21926, 3, 2007, 7520, 20852, 2356, 16, 2427, 1966, 3335, 25118, 18, 1922, 2052, 2161, 21926, 9432, 5481, 18973, 2719, 2007, 15331, 17125, 2381, 1922, 3615, 18, 22, 3]}, "items": [{"id": "p_1735", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_1736", "content": "thiopental [SEP] n this study naloxone reversed respiratory paralysis induced by thiopental in rats. 25 mg/kg, i.v. thiopental produced anesthesia without ", "tokenized_content": [2, 15331, 17125, 2381, 3, 56, 2052, 2161, 21926, 9432, 5481, 18973, 2719, 2007, 15331, 17125, 2381, 1922, 3615, 18, 2637, 2786, 19, 3621, 16, 51, 18, 64, 18, 15331, 17125, 3]}, "items": [{"id": "p_1736", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_1737", "content": "GABA [SEP] roduced anesthesia without altering respiratory rate, increased GABA, decreased glutamate, and had no effect on aspartate or glycine", "tokenized_content": [2, 7992, 3, 6275, 2418, 8871, 2979, 12571, 5481, 2769, 16, 2502, 7992, 16, 3261, 7627, 16, 1930, 2430, 2239, 2495, 1990, 12878, 2014, 10646, 3]}, "items": [{"id": "p_1737", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1738", "content": "glutamate [SEP] ia without altering respiratory rate, increased GABA, decreased glutamate, and had no effect on aspartate or glycine levels compared to c", "tokenized_content": [2, 7627, 3, 11640, 2979, 12571, 5481, 2769, 16, 2502, 7992, 16, 3261, 7627, 16, 1930, 2430, 2239, 2495, 1990, 12878, 2014, 10646, 2428, 2452, 1942, 45, 3]}, "items": [{"id": "p_1738", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_1739", "content": "aspartate [SEP] rate, increased GABA, decreased glutamate, and had no effect on aspartate or glycine levels compared to controls in rat cortex and brain ", "tokenized_content": [2, 12878, 3, 2769, 16, 2502, 7992, 16, 3261, 7627, 16, 1930, 2430, 2239, 2495, 1990, 12878, 2014, 10646, 2428, 2452, 1942, 3562, 1922, 3067, 4997, 1930, 3068, 3]}, "items": [{"id": "p_1739", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_1740", "content": "glycine [SEP] ed GABA, decreased glutamate, and had no effect on aspartate or glycine levels compared to controls in rat cortex and brain stem. Pretr", "tokenized_content": [2, 10646, 3, 3347, 7992, 16, 3261, 7627, 16, 1930, 2430, 2239, 2495, 1990, 12878, 2014, 10646, 2428, 2452, 1942, 3562, 1922, 3067, 4997, 1930, 3068, 4402, 18, 24532, 1005, 3]}, "items": [{"id": "p_1740", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_1741", "content": "thiosemicarbazide [SEP] ontrols in rat cortex and brain stem. Pretreatment of rats with thiosemicarbazide for 30 minutes abolished the anesthetic action as well as the r", "tokenized_content": [2, 15331, 21696, 6102, 16007, 29895, 3, 9056, 2226, 1036, 1922, 3067, 4997, 1930, 3068, 4402, 18, 9111, 1927, 3615, 1956, 15331, 21696, 6102, 16007, 29895, 1958, 2627, 4814, 10979, 1920, 3]}, "items": [{"id": "p_1741", "content": "thiosemicarbazide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15331, 21696, 6102, 16007, 29895, 3, 3]}]}
{"query": {"id": "q_1742", "content": "respiratory arrest [SEP] essant action of thiopental. 50 mg/kg, i.v. thiopental produced respiratory arrest with further increase in GABA and decrease in glutamate again i", "tokenized_content": [2, 5481, 8048, 3, 4023, 2031, 4615, 1927, 15331, 17125, 2381, 18, 2761, 2786, 19, 3621, 16, 51, 18, 64, 18, 15331, 17125, 2381, 4152, 5481, 8048, 1956, 2520, 2760, 1922, 3]}, "items": [{"id": "p_1742", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_1743", "content": "amino acids [SEP] ate again in cortex and brain stem without affecting any of the amino acids studied in four regions of rat brain. Naloxone (2.5 mg/kg, i.v.", "tokenized_content": [2, 3835, 4576, 3, 30280, 3116, 1922, 4997, 1930, 3068, 4402, 2979, 7359, 2967, 1927, 1920, 3835, 4576, 3942, 1922, 3006, 3451, 1927, 3067, 3068, 18, 21926, 12, 22, 18, 25, 3]}, "items": [{"id": "p_1743", "content": "Amino Acids [SEP] Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits", "score": 1, "type": null, "tokenized_content": [2, 3835, 4576, 3, 6805, 4300, 1988, 4933, 5531, 1925, 3835, 12, 17, 15410, 13, 1930, 43, 9943, 12, 17, 20729, 13, 2210, 18, 7639, 4595, 17, 3835, 4576, 2032, 1920, 6991, 3]}]}
{"query": {"id": "q_1744", "content": "Naloxone [SEP] ng any of the amino acids studied in four regions of rat brain. Naloxone (2.5 mg/kg, i.v.) reversed respiratory paralysis, glutamate and", "tokenized_content": [2, 21926, 3, 4375, 2967, 1927, 1920, 3835, 4576, 3942, 1922, 3006, 3451, 1927, 3067, 3068, 18, 21926, 12, 22, 18, 25, 2786, 19, 3621, 16, 51, 18, 64, 18, 13, 3]}, "items": [{"id": "p_1744", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_1745", "content": "infection by hepatitis B virus [SEP] National project on the prevention of mother-to-infant infection by hepatitis B virus in Japan.", "tokenized_content": [2, 2909, 2007, 7977, 44, 3413, 3, 3852, 5539, 1990, 1920, 5455, 1927, 7999, 17, 1942, 17, 8125, 2909, 2007, 7977, 44, 3413, 1922, 5834, 18, 3]}, "items": [{"id": "p_1745", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_1746", "content": "infection by hepatitis B virus [SEP] Japan, a nationwide prevention program against mother-to-infant infection by hepatitis B virus (HBV) started in 1985. This program consists of double screenin", "tokenized_content": [2, 2909, 2007, 7977, 44, 3413, 3, 5834, 16, 43, 19006, 5455, 3688, 3316, 7999, 17, 1942, 17, 8125, 2909, 2007, 7977, 44, 3413, 12, 8738, 13, 8074, 1922, 11917, 18, 3]}, "items": [{"id": "p_1746", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_1747", "content": "hepatitis B surface antigen [SEP] nt women and prophylactic treatment to the infants born to both hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers. The", "tokenized_content": [2, 7977, 44, 3154, 4730, 3, 5891, 3089, 1930, 14847, 2311, 1942, 1920, 5969, 8813, 1942, 2321, 7977, 44, 3154, 4730, 12, 17596, 13, 1930, 7977, 44, 47, 4730, 12, 25162, 3]}, "items": [{"id": "p_1747", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_1748", "content": "HBsAg [SEP] atment to the infants born to both hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers. These infa", "tokenized_content": [2, 17596, 3, 7513, 1939, 1942, 1920, 5969, 8813, 1942, 2321, 7977, 44, 3154, 4730, 12, 17596, 13, 1930, 7977, 44, 47, 4730, 12, 25162, 13, 2843, 7026, 18, 2144, 2122, 3]}, "items": [{"id": "p_1748", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_1749", "content": "hepatitis B e antigen [SEP] he infants born to both hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers. These infants are treated with two in", "tokenized_content": [2, 7977, 44, 47, 4730, 3, 2234, 5969, 8813, 1942, 2321, 7977, 44, 3154, 4730, 12, 17596, 13, 1930, 7977, 44, 47, 4730, 12, 25162, 13, 2843, 7026, 18, 2144, 5969, 3]}, "items": [{"id": "p_1749", "content": "Hepatitis B e Antigens [SEP] A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic he", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 47, 7769, 3, 43, 6538, 2712, 2210, 1927, 7769, 2435, 1922, 1920, 3582, 2444, 2409, 1920, 20905, 3193, 1927, 7977, 44, 2014, 1922, 18354, 3724, 2234, 3]}]}
{"query": {"id": "q_1750", "content": "HBeAg [SEP]  hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers. These infants are treated with two injection", "tokenized_content": [2, 25162, 3, 7977, 44, 3154, 4730, 12, 17596, 13, 1930, 7977, 44, 47, 4730, 12, 25162, 13, 2843, 7026, 18, 2144, 5969, 2032, 2868, 1956, 2288, 4107, 3]}, "items": [{"id": "p_1750", "content": "Hepatitis B e Antigens [SEP] A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic he", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 47, 7769, 3, 43, 6538, 2712, 2210, 1927, 7769, 2435, 1922, 1920, 3582, 2444, 2409, 1920, 20905, 3193, 1927, 7977, 44, 2014, 1922, 18354, 3724, 2234, 3]}]}
{"query": {"id": "q_1751", "content": "hepatitis B [SEP] onwide prevention program against mother-to-infant infection by hepatitis B virus (HBV) started in 1985. This program consists of double sc", "tokenized_content": [2, 7977, 44, 3, 1990, 7641, 5455, 3688, 3316, 7999, 17, 1942, 17, 8125, 2909, 2007, 7977, 44, 3413, 12, 8738, 13, 8074, 1922, 11917, 18, 2052, 3688, 7543, 1927, 4825, 3]}, "items": [{"id": "p_1751", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_1752", "content": "hepatitis B vaccine [SEP] globulin (HBIG) and at least three injections of plasma derived hepatitis B vaccine. We sent questionnaires about the numbers of each procedure or ", "tokenized_content": [2, 7977, 44, 5955, 3, 24366, 12, 4873, 1950, 13, 1930, 2019, 3464, 2559, 8775, 1927, 3582, 3595, 7977, 44, 5955, 18, 2038, 8437, 9343, 3001, 1920, 4630, 1927, 2362, 4360, 3]}, "items": [{"id": "p_1752", "content": "Hepatitis B Vaccines [SEP] Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepa", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 9375, 3, 9375, 2014, 6610, 9375, 3165, 11588, 7977, 44, 2014, 2673, 1927, 2496, 4594, 7769, 1930, 4609, 1942, 4625, 3357, 1019, 3]}]}
{"query": {"id": "q_1753", "content": "prostaglandin D2 [SEP] Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice.", "tokenized_content": [2, 15900, 8631, 3, 19034, 2564, 2719, 2007, 22782, 4183, 1927, 15900, 8631, 16, 6602, 16, 2014, 11063, 4595, 1942, 11993, 2518, 18, 3]}, "items": [{"id": "p_1753", "content": "Prostaglandin D2 [SEP] The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesize", "score": 1, "type": null, "tokenized_content": [2, 15900, 8631, 3, 1920, 7944, 21271, 9483, 1927, 19571, 2687, 18, 2176, 1977, 6988, 4073, 2936, 1927, 9731, 2094, 1930, 1977, 2222, 15541, 3]}]}
{"query": {"id": "q_1754", "content": "prostaglandins [SEP] The effects of intrathecal administration of prostaglandins on pain responses in conscious mice were evaluated by using hot", "tokenized_content": [2, 25674, 3, 1920, 2564, 1927, 22782, 4183, 1927, 25674, 1990, 3594, 3387, 1922, 11993, 2518, 1985, 3747, 2007, 2193, 9529, 3]}, "items": [{"id": "p_1754", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1755", "content": "pain [SEP] The effects of intrathecal administration of prostaglandins on pain responses in conscious mice were evaluated by using hot plate a", "tokenized_content": [2, 3594, 3, 1920, 2564, 1927, 22782, 4183, 1927, 25674, 1990, 3594, 3387, 1922, 11993, 2518, 1985, 3747, 2007, 2193, 9529, 5500, 43, 3]}, "items": [{"id": "p_1755", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_1756", "content": "acetic acid [SEP] sponses in conscious mice were evaluated by using hot plate and acetic acid writhing tests. Prostaglandin D2 (0.5-3 ng/mouse) had a hyperal", "tokenized_content": [2, 13069, 2687, 3, 15312, 1918, 1922, 11993, 2518, 1985, 3747, 2007, 2193, 9529, 5500, 1930, 13069, 2687, 4573, 1953, 1941, 4026, 18, 15900, 8631, 12, 20, 18, 25, 17, 23, 3]}, "items": [{"id": "p_1756", "content": "Acetic Acid [SEP] Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as", "score": 1, "type": null, "tokenized_content": [2, 13069, 2687, 3, 4863, 1927, 1920, 6638, 1927, 5757, 1930, 1927, 1920, 21243, 3653, 10888, 1929, 1927, 10211, 18, 2176, 1977, 2251, 10753, 16, 14647, 23125, 16, 1966, 3]}]}
{"query": {"id": "q_1757", "content": "Prostaglandin D2 [SEP] re evaluated by using hot plate and acetic acid writhing tests. Prostaglandin D2 (0.5-3 ng/mouse) had a hyperalgesic action on the response to a", "tokenized_content": [2, 15900, 8631, 3, 1964, 3747, 2007, 2193, 9529, 5500, 1930, 13069, 2687, 4573, 1953, 1941, 4026, 18, 15900, 8631, 12, 20, 18, 25, 17, 23, 4375, 19, 3321, 13, 2430, 3]}, "items": [{"id": "p_1757", "content": "Prostaglandin D2 [SEP] The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesize", "score": 1, "type": null, "tokenized_content": [2, 15900, 8631, 3, 1920, 7944, 21271, 9483, 1927, 19571, 2687, 18, 2176, 1977, 6988, 4073, 2936, 1927, 9731, 2094, 1930, 1977, 2222, 15541, 3]}]}
{"query": {"id": "q_1758", "content": "hyperalgesic [SEP] ic acid writhing tests. Prostaglandin D2 (0.5-3 ng/mouse) had a hyperalgesic action on the response to a hot plate during a 3-60 min period ", "tokenized_content": [2, 20543, 1935, 3, 3996, 2687, 4573, 1953, 1941, 4026, 18, 15900, 8631, 12, 20, 18, 25, 17, 23, 4375, 19, 3321, 13, 2430, 43, 20543, 1935, 4615, 1990, 1920, 2644, 3]}, "items": [{"id": "p_1758", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_1759", "content": "Prostaglandin E2 [SEP] sponse to a hot plate during a 3-60 min period after injection. Prostaglandin E2 showed a hyperalgesic effect at doses of 1 pg to 10 ng/mouse, b", "tokenized_content": [2, 15900, 6602, 3, 15312, 1021, 1942, 43, 9529, 5500, 2409, 43, 23, 17, 3276, 2360, 3047, 2256, 4107, 18, 15900, 6602, 2594, 43, 20543, 1935, 2495, 2019, 5312, 1927, 21, 3]}, "items": [{"id": "p_1759", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_1760", "content": "pg [SEP] on. Prostaglandin E2 showed a hyperalgesic effect at doses of 1 pg to 10 ng/mouse, but the effect lasted shorter (3-30 min) than t", "tokenized_content": [2, 5306, 3, 1990, 18, 15900, 6602, 2594, 43, 20543, 1935, 2495, 2019, 5312, 1927, 21, 5306, 1942, 2119, 4375, 19, 3321, 16, 2308, 1920, 2495, 16276, 7310, 12, 23, 17, 3]}, "items": [{"id": "p_1760", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_1761", "content": "prostaglandin D2 [SEP] ng/mouse, but the effect lasted shorter (3-30 min) than that of prostaglandin D2. Similar results were obtained by acetic acid writhing tests. T", "tokenized_content": [2, 15900, 8631, 3, 4375, 19, 3321, 16, 2308, 1920, 2495, 16276, 7310, 12, 23, 17, 2627, 2360, 13, 2254, 1988, 1927, 15900, 8631, 18, 2551, 2274, 1985, 2926, 2007, 13069, 3]}, "items": [{"id": "p_1761", "content": "Prostaglandin D2 [SEP] The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesize", "score": 1, "type": null, "tokenized_content": [2, 15900, 8631, 3, 1920, 7944, 21271, 9483, 1927, 19571, 2687, 18, 2176, 1977, 6988, 4073, 2936, 1927, 9731, 2094, 1930, 1977, 2222, 15541, 3]}]}
{"query": {"id": "q_1762", "content": "AH6809 [SEP] tance P antagonist (greater than or equal to 100 ng) but not by AH6809, a prostanoid EP1-receptor antagonist. Conversely, prostaglandi", "tokenized_content": [2, 9646, 6735, 13192, 3, 10434, 1972, 58, 8151, 12, 3430, 2254, 2014, 5557, 1942, 2813, 4375, 13, 2308, 2084, 2007, 9646, 6735, 13192, 16, 43, 4876, 9286, 1960, 2630, 1009, 3]}, "items": [{"id": "p_1762", "content": "6-isopropoxy-9-oxoxanthene-2-carboxylic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26, 17, 25549, 7221, 17, 29, 17, 18588, 11414, 4905, 22467, 1021, 17, 22, 17, 18708, 2687, 3, 3]}]}
{"query": {"id": "q_1763", "content": "prostaglandin E2 [SEP] ot by AH6809, a prostanoid EP1-receptor antagonist. Conversely, prostaglandin E2-induced hyperalgesia was blocked by AH6809 (greater than or equ", "tokenized_content": [2, 15900, 6602, 3, 7608, 2007, 9646, 6735, 13192, 16, 43, 4876, 9286, 1960, 2630, 1009, 17, 3148, 8151, 18, 8990, 16, 15900, 6602, 17, 2719, 21525, 1982, 6923, 2007, 9646, 3]}, "items": [{"id": "p_1763", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_1764", "content": "hyperalgesia [SEP] d EP1-receptor antagonist. Conversely, prostaglandin E2-induced hyperalgesia was blocked by AH6809 (greater than or equal to 500 ng) but not", "tokenized_content": [2, 21525, 3, 46, 2630, 1009, 17, 3148, 8151, 18, 8990, 16, 15900, 6602, 17, 2719, 21525, 1982, 6923, 2007, 9646, 6735, 13192, 12, 3430, 2254, 2014, 5557, 1942, 4599, 4375, 3]}, "items": [{"id": "p_1764", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_1765", "content": "Prostaglandin F2 alpha [SEP] than or equal to 500 ng) but not by the substance P antagonist. Prostaglandin F2 alpha had little effect on pain responses. These results demonstrate ", "tokenized_content": [2, 15900, 11063, 4595, 3, 2254, 2014, 5557, 1942, 4599, 4375, 13, 2308, 2084, 2007, 1920, 7311, 58, 8151, 18, 15900, 11063, 4595, 2430, 5082, 2495, 1990, 3594, 3387, 18, 2144, 3]}, "items": [{"id": "p_1765", "content": "Dinoprost [SEP] A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile prop", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 3, 43, 10414, 6966, 15900, 1988, 2258, 16462, 19977, 16, 12867, 6586, 16, 1930, 11380, 3058, 28278, 1939, 4209, 18, 2810, 1942, 2496, 22866, 12334, 10261, 2341, 2383, 5062, 3]}]}
{"query": {"id": "q_1766", "content": "atrial tachyarrhythmia [SEP] Swallowing-induced atrial tachyarrhythmia triggered by salbutamol: case report and review of the literatu", "tokenized_content": [2, 9224, 12762, 9771, 18858, 10245, 6026, 3, 20496, 17, 2719, 9224, 12762, 9771, 18858, 10245, 6026, 9436, 2007, 3370, 16119, 20624, 30, 3087, 3809, 1930, 3043, 1927, 1920, 4154, 1926, 3]}, "items": [{"id": "p_1766", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_1767", "content": "salbutamol [SEP] Swallowing-induced atrial tachyarrhythmia triggered by salbutamol: case report and review of the literature.", "tokenized_content": [2, 3370, 16119, 20624, 3, 20496, 17, 2719, 9224, 12762, 9771, 18858, 10245, 6026, 9436, 2007, 3370, 16119, 20624, 30, 3087, 3809, 1930, 3043, 1927, 1920, 4431, 18, 3]}, "items": [{"id": "p_1767", "content": "Albuterol [SEP] A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared", "score": 1, "type": null, "tokenized_content": [2, 5311, 4834, 1945, 3, 43, 3662, 17, 8290, 4666, 17, 22, 13672, 7829, 1988, 1977, 5985, 2251, 1966, 43, 26272, 3061, 5899, 1942, 2297, 6678, 18, 5311, 4834, 1945, 1977, 4649, 3]}]}
{"query": {"id": "q_1768", "content": "atrial tachyarrhythmia [SEP]  discomfort while swallowing. On electrocardiogram, episodes of atrial tachyarrhythmia were recorded immediately after swallowing; 24-hour Holter moni", "tokenized_content": [2, 9224, 12762, 9771, 18858, 10245, 6026, 3, 15335, 2679, 20496, 18, 1990, 22477, 16, 9232, 1927, 9224, 12762, 9771, 18858, 10245, 6026, 1985, 4562, 6183, 2256, 20496, 31, 2686, 17, 3]}, "items": [{"id": "p_1768", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_1769", "content": "arrhythmia [SEP] while swallowing. On electrocardiogram, episodes of atrial tachyarrhythmia were recorded immediately after swallowing; 24-hour Holter moni", "tokenized_content": [2, 18346, 3, 2679, 20496, 18, 1990, 22477, 16, 9232, 1927, 9224, 12762, 9771, 18858, 10245, 6026, 1985, 4562, 6183, 2256, 20496, 31, 2686, 17, 6231, 8001, 1967, 2399, 1033, 3]}, "items": [{"id": "p_1769", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_1770", "content": "atenolol [SEP] rded several events. The arrhythmia resolved after therapy with atenolol, but recurred a year later. The patient noticed that before the", "tokenized_content": [2, 30280, 11873, 6012, 1024, 3, 8695, 1919, 2980, 3916, 18, 1920, 18346, 8397, 2256, 3181, 1956, 30280, 11873, 6012, 1024, 16, 2308, 4734, 1919, 43, 2476, 3690, 18, 1920, 2774, 3]}, "items": [{"id": "p_1770", "content": "Atenolol [SEP] A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative ino", "score": 1, "type": null, "tokenized_content": [2, 30280, 11873, 6012, 1024, 3, 43, 21129, 4127, 25419, 2185, 4666, 17, 21, 13672, 14580, 19705, 3879, 1930, 10397, 2551, 1942, 21395, 16, 2308, 2979, 43, 3136, 26848, 3]}]}
{"query": {"id": "q_1771", "content": "salbutamol [SEP] ed that before these episodes he had been using an inhalator of salbutamol. After stopping the beta-agonist, and after a week with the ate", "tokenized_content": [2, 3370, 16119, 20624, 3, 3347, 1988, 3119, 2144, 9232, 2234, 2430, 2252, 2193, 1925, 9927, 3061, 1927, 3370, 16119, 20624, 18, 2256, 20225, 1920, 4666, 17, 7829, 16, 1930, 2256, 3]}, "items": [{"id": "p_1771", "content": "Albuterol [SEP] A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared", "score": 1, "type": null, "tokenized_content": [2, 5311, 4834, 1945, 3, 43, 3662, 17, 8290, 4666, 17, 22, 13672, 7829, 1988, 1977, 5985, 2251, 1966, 43, 26272, 3061, 5899, 1942, 2297, 6678, 18, 5311, 4834, 1945, 1977, 4649, 3]}]}
{"query": {"id": "q_1772", "content": "SIAT [SEP] ppeared. DISCUSSION: Swallowing-induced atrial tachyarrhythmia (SIAT) is a rare phenomenon. Fewer than 50 cases of SIAT have been de", "tokenized_content": [2, 26352, 1031, 3, 29296, 7119, 18, 7248, 30, 20496, 17, 2719, 9224, 12762, 9771, 18858, 10245, 6026, 12, 26352, 1031, 13, 1977, 43, 5844, 7902, 18, 7380, 2254, 2761, 2919, 3]}, "items": [{"id": "p_1772", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_1773", "content": "Salbutamol [SEP] rgery, and radiofrequency catheter ablation (RFCA). CONCLUSION: Salbutamol is presented here as a possible trigger for SIAT. Although it i", "tokenized_content": [2, 3370, 16119, 20624, 3, 9372, 2734, 16, 1930, 23660, 8421, 9413, 12, 7751, 3375, 13, 18, 4180, 30, 3370, 16119, 20624, 1977, 3549, 3410, 1966, 43, 3216, 6086, 1958, 26352, 3]}, "items": [{"id": "p_1773", "content": "Albuterol [SEP] A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared", "score": 1, "type": null, "tokenized_content": [2, 5311, 4834, 1945, 3, 43, 3662, 17, 8290, 4666, 17, 22, 13672, 7829, 1988, 1977, 5985, 2251, 1966, 43, 26272, 3061, 5899, 1942, 2297, 6678, 18, 5311, 4834, 1945, 1977, 4649, 3]}]}
{"query": {"id": "q_1774", "content": "tachycardia [SEP] l to think that a beta-agonist like salbutamol (known to induce tachycardia) may be the trigger of adrenergic reflexes originating in the e", "tokenized_content": [2, 17397, 3, 54, 1942, 8727, 1988, 43, 4666, 17, 7829, 3189, 3370, 16119, 20624, 12, 3171, 1942, 4769, 17397, 13, 2278, 1998, 1920, 6086, 1927, 13672, 24064, 14391, 1922, 1920, 3]}, "items": [{"id": "p_1774", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_1775", "content": "Coenzyme Q10 [SEP] Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.", "tokenized_content": [2, 22051, 22027, 1008, 3, 22051, 22027, 1008, 2311, 20611, 1036, 3939, 9284, 27880, 1922, 2518, 18, 3]}, "items": [{"id": "p_1775", "content": "coenzyme Q10 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22051, 22027, 1008, 3, 3]}]}
{"query": {"id": "q_1776", "content": "cisplatin [SEP] Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.", "tokenized_content": [2, 9284, 3, 22051, 22027, 1008, 2311, 20611, 1036, 3939, 9284, 27880, 1922, 2518, 18, 3]}, "items": [{"id": "p_1776", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_1777", "content": "nephrotoxicity [SEP] Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.", "tokenized_content": [2, 27880, 3, 22051, 22027, 1008, 2311, 20611, 1036, 3939, 9284, 27880, 1922, 2518, 18, 3]}, "items": [{"id": "p_1777", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1778", "content": "coenzyme Q10 [SEP] The nephroprotective effect of coenzyme Q10 was investigated in mice with acute renal injury induced by a s", "tokenized_content": [2, 22051, 22027, 1008, 3, 1920, 7737, 2928, 4424, 12323, 2495, 1927, 22051, 22027, 1008, 1982, 3845, 1922, 2518, 1956, 3939, 4604, 4047, 2719, 2007, 43, 61, 3]}, "items": [{"id": "p_1778", "content": "coenzyme Q10 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22051, 22027, 1008, 3, 3]}]}
{"query": {"id": "q_1779", "content": "acute renal injury [SEP] protective effect of coenzyme Q10 was investigated in mice with acute renal injury induced by a single i.p. injection of cisplatin (5 mg/kg). Coen", "tokenized_content": [2, 3939, 4604, 4047, 3, 6337, 2495, 1927, 22051, 22027, 1008, 1982, 3845, 1922, 2518, 1956, 3939, 4604, 4047, 2719, 2007, 43, 2957, 51, 18, 58, 18, 4107, 1927, 9284, 12, 3]}, "items": [{"id": "p_1779", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1780", "content": "cisplatin [SEP] e with acute renal injury induced by a single i.p. injection of cisplatin (5 mg/kg). Coenzyme Q10 treatment (10 mg/kg/day, i.p.) was appl", "tokenized_content": [2, 9284, 3, 47, 1956, 3939, 4604, 4047, 2719, 2007, 43, 2957, 51, 18, 58, 18, 4107, 1927, 9284, 12, 25, 2786, 19, 3621, 13, 18, 22051, 22027, 1008, 2311, 12, 3]}, "items": [{"id": "p_1780", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_1781", "content": "Coenzyme Q10 [SEP] jury induced by a single i.p. injection of cisplatin (5 mg/kg). Coenzyme Q10 treatment (10 mg/kg/day, i.p.) was applied for 6 consecutive da", "tokenized_content": [2, 22051, 22027, 1008, 3, 11540, 1012, 2719, 2007, 43, 2957, 51, 18, 58, 18, 4107, 1927, 9284, 12, 25, 2786, 19, 3621, 13, 18, 22051, 22027, 1008, 2311, 12, 2119, 3]}, "items": [{"id": "p_1781", "content": "coenzyme Q10 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22051, 22027, 1008, 3, 3]}]}
{"query": {"id": "q_1782", "content": "blood urea nitrogen [SEP] re cisplatin administration. Coenzyme Q10 significantly reduced blood urea nitrogen and serum creatinine levels which were increased by cisplatin. ", "tokenized_content": [2, 2877, 10505, 6634, 3, 1964, 9284, 4183, 18, 22051, 22027, 1008, 2567, 3028, 2877, 10505, 6634, 1930, 3256, 9374, 2428, 2154, 1985, 2502, 2007, 9284, 18, 3]}, "items": [{"id": "p_1782", "content": "Blood Urea Nitrogen [SEP] The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% highe", "score": 1, "type": null, "tokenized_content": [2, 2877, 10505, 6634, 3, 1920, 10505, 3110, 1927, 1920, 2877, 9662, 1922, 4430, 1927, 6634, 3919, 18, 3256, 12, 3582, 13, 10505, 6634, 1977, 3993, 2369, 9, 2149, 1021, 3]}]}
{"query": {"id": "q_1783", "content": "creatinine [SEP] oenzyme Q10 significantly reduced blood urea nitrogen and serum creatinine levels which were increased by cisplatin. Coenzyme Q10 signific", "tokenized_content": [2, 9374, 3, 17353, 1022, 9318, 22027, 1008, 2567, 3028, 2877, 10505, 6634, 1930, 3256, 9374, 2428, 2154, 1985, 2502, 2007, 9284, 18, 22051, 22027, 1008, 2208, 3]}, "items": [{"id": "p_1783", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_1784", "content": "reduced glutathione [SEP] tly compensated deficits in the antioxidant defense mechanisms (reduced glutathione level and superoxide dismutase activity), suppressed lipid pero", "tokenized_content": [2, 3028, 9153, 3, 10474, 1012, 17566, 7961, 1922, 1920, 7335, 9720, 3531, 12, 3028, 9153, 2237, 1930, 10738, 16679, 2455, 13, 16, 7657, 4486, 2079, 1037, 3]}, "items": [{"id": "p_1784", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_1785", "content": "superoxide [SEP] e antioxidant defense mechanisms (reduced glutathione level and superoxide dismutase activity), suppressed lipid peroxidation, decreased t", "tokenized_content": [2, 10738, 3, 47, 7335, 9720, 3531, 12, 3028, 9153, 2237, 1930, 10738, 16679, 2455, 13, 16, 7657, 4486, 14214, 16, 3261, 62, 3]}, "items": [{"id": "p_1785", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_1786", "content": "tumor [SEP] ty), suppressed lipid peroxidation, decreased the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentrat", "tokenized_content": [2, 2798, 3, 6227, 13, 16, 7657, 4486, 14214, 16, 3261, 1920, 17554, 1927, 2798, 7476, 2991, 17, 4595, 16, 10233, 7491, 1930, 13299, 4755, 2587, 1926, 3]}, "items": [{"id": "p_1786", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1787", "content": "necrosis [SEP] uppressed lipid peroxidation, decreased the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentration, and ", "tokenized_content": [2, 7476, 3, 2353, 6153, 4486, 14214, 16, 3261, 1920, 17554, 1927, 2798, 7476, 2991, 17, 4595, 16, 10233, 7491, 1930, 13299, 4755, 3110, 16, 1930, 3]}, "items": [{"id": "p_1787", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_1788", "content": "nitric oxide [SEP] ation, decreased the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentration, and attenuated the reductions o", "tokenized_content": [2, 10233, 7491, 3, 2019, 2001, 16, 3261, 1920, 17554, 1927, 2798, 7476, 2991, 17, 4595, 16, 10233, 7491, 1930, 13299, 4755, 3110, 16, 1930, 8060, 1920, 9350, 57, 3]}, "items": [{"id": "p_1788", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_1789", "content": "platinum [SEP] the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentration, and attenuated the reductions of selenium an", "tokenized_content": [2, 13299, 3, 1920, 17554, 1927, 2798, 7476, 2991, 17, 4595, 16, 10233, 7491, 1930, 13299, 4755, 3110, 16, 1930, 8060, 1920, 9350, 1927, 17277, 1925, 3]}, "items": [{"id": "p_1789", "content": "Platinum [SEP] Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th e", "score": 1, "type": null, "tokenized_content": [2, 13299, 3, 13299, 18, 43, 7881, 16, 3793, 16, 9495, 2471, 6048, 16, 18994, 12347, 16, 11241, 2529, 5440, 16, 11241, 3388, 16030, 18, 7102, 16, 17530, 4401, 18, 12, 2037, 19638, 4702, 16, 3158, 1963, 47, 3]}]}
{"query": {"id": "q_1790", "content": "selenium [SEP] nd platinum ion concentration, and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administr", "tokenized_content": [2, 17277, 3, 8026, 13299, 4755, 3110, 16, 1930, 8060, 1920, 9350, 1927, 17277, 1930, 7997, 6982, 1922, 4604, 2960, 4306, 2037, 9284, 10473, 3]}, "items": [{"id": "p_1790", "content": "Selenium [SEP] An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals an", "score": 1, "type": null, "tokenized_content": [2, 17277, 3, 1925, 6149, 1956, 1920, 11241, 17530, 2058, 16, 11241, 2529, 3540, 16, 1930, 11241, 3388, 5440, 18, 4746, 18, 2176, 1977, 1925, 4415, 22522, 1939, 1958, 9902, 1925, 3]}]}
{"query": {"id": "q_1791", "content": "zinc [SEP] on concentration, and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administration. Al", "tokenized_content": [2, 7997, 3, 1990, 3110, 16, 1930, 8060, 1920, 9350, 1927, 17277, 1930, 7997, 6982, 1922, 4604, 2960, 4306, 2037, 9284, 4183, 18, 1969, 3]}, "items": [{"id": "p_1791", "content": "Zinc [SEP] A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essentia", "score": 1, "type": null, "tokenized_content": [2, 7997, 3, 43, 16790, 6149, 1927, 11241, 2529, 2627, 1930, 11241, 3388, 4459, 18, 3738, 18, 2176, 1977, 43, 4680, 9950, 6149, 1922, 1920, 3986, 16, 7402, 1925, 4023, 7721, 3]}]}
{"query": {"id": "q_1792", "content": "renal tissue damage [SEP] resulted from cisplatin administration. Also, histopathological renal tissue damage mediated by cisplatin was ameliorated by coenzyme Q10 treatment", "tokenized_content": [2, 4604, 2960, 4293, 3, 4306, 2037, 9284, 4183, 18, 2222, 16, 11777, 4604, 2960, 4293, 3434, 2007, 9284, 1982, 22085, 2007, 22051, 22027, 1008, 2311, 3]}, "items": [{"id": "p_1792", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1793", "content": "nephrotoxicity [SEP] potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice.", "tokenized_content": [2, 27880, 3, 2889, 4272, 8297, 1942, 9145, 3316, 3939, 9284, 27880, 5384, 11989, 1922, 2535, 4695, 18, 3]}, "items": [{"id": "p_1793", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1794", "content": "Metformin [SEP] Metformin prevents experimental gentamicin-induced nephropathy by a mitoc", "tokenized_content": [2, 11885, 3, 11885, 10299, 3599, 17144, 17, 2719, 15582, 2007, 43, 25959, 1030, 3]}, "items": [{"id": "p_1794", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1795", "content": "gentamicin [SEP] Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.", "tokenized_content": [2, 17144, 3, 11885, 10299, 3599, 17144, 17, 2719, 15582, 2007, 43, 6489, 17, 3100, 3374, 18, 3]}, "items": [{"id": "p_1795", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_1796", "content": "nephropathy [SEP] Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.", "tokenized_content": [2, 15582, 3, 11885, 10299, 3599, 17144, 17, 2719, 15582, 2007, 43, 6489, 17, 3100, 3374, 18, 3]}, "items": [{"id": "p_1796", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1797", "content": "metformin [SEP] The antidiabetic drug metformin can diminish apoptosis induced by oxidative stress in endotheli", "tokenized_content": [2, 11885, 3, 1920, 26818, 2838, 11885, 2112, 16072, 4091, 2719, 2007, 5163, 3071, 1922, 4579, 11085, 3]}, "items": [{"id": "p_1797", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1798", "content": "vascular dysfunction [SEP] is induced by oxidative stress in endothelial cells and prevent vascular dysfunction even in nondiabetic patients. Here we tested whether it has a b", "tokenized_content": [2, 4541, 5273, 3, 1977, 2719, 2007, 5163, 3071, 1922, 5003, 2094, 1930, 4625, 4541, 5273, 3385, 1922, 26819, 2132, 18, 3410, 2038, 3620, 3053, 2176, 2258, 43, 44, 3]}, "items": [{"id": "p_1798", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_1799", "content": "gentamicin [SEP]  we tested whether it has a beneficial effect in a rat model of gentamicin toxicity. Mitochondrial analysis, respiration intensity, levels", "tokenized_content": [2, 17144, 3, 2038, 3620, 3053, 2176, 2258, 43, 6928, 2495, 1922, 43, 3067, 2322, 1927, 17144, 5532, 18, 4596, 2333, 16, 11695, 4266, 16, 2428, 3]}, "items": [{"id": "p_1799", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_1800", "content": "toxicity [SEP] whether it has a beneficial effect in a rat model of gentamicin toxicity. Mitochondrial analysis, respiration intensity, levels of react", "tokenized_content": [2, 5532, 3, 3053, 2176, 2258, 43, 6928, 2495, 1922, 43, 3067, 2322, 1927, 17144, 5532, 18, 4596, 2333, 16, 11695, 4266, 16, 2428, 1927, 9793, 3]}, "items": [{"id": "p_1800", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1801", "content": "oxygen [SEP] tochondrial analysis, respiration intensity, levels of reactive oxygen species, permeability transition, and cytochrome c release were", "tokenized_content": [2, 4612, 3, 21682, 10647, 10249, 3027, 1923, 2333, 16, 11695, 4266, 16, 2428, 1927, 6079, 4612, 3038, 16, 8828, 4832, 16, 1930, 9387, 45, 4012, 1985, 3]}, "items": [{"id": "p_1801", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_1802", "content": "Metformin [SEP] ase were assessed 3 and 6 days after gentamicin administration. Metformin treatment fully blocked gentamicin-mediated acute renal failure", "tokenized_content": [2, 11885, 3, 28826, 1985, 3683, 23, 1930, 26, 3000, 2256, 17144, 4183, 18, 11885, 2311, 5437, 6923, 17144, 17, 3434, 3939, 4604, 4574, 3]}, "items": [{"id": "p_1802", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1803", "content": "acute renal failure [SEP] stration. Metformin treatment fully blocked gentamicin-mediated acute renal failure. This was accompanied by a lower activity of N-acetyl-beta-D-gl", "tokenized_content": [2, 3939, 4604, 4574, 3, 9402, 1929, 18, 11885, 2311, 5437, 6923, 17144, 17, 3434, 3939, 4604, 4574, 18, 2052, 1982, 7936, 2007, 43, 2826, 2455, 1927, 56, 17, 6894, 17, 3]}, "items": [{"id": "p_1803", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1804", "content": "kidney dysfunction [SEP]  days after gentamicin administration. These in vivo markers of kidney dysfunction and their correction by metformin were complemented by in vitro", "tokenized_content": [2, 5245, 5273, 3, 3000, 2256, 17144, 4183, 18, 2144, 1922, 3597, 4432, 1927, 5245, 5273, 1930, 2310, 6820, 2007, 11885, 1985, 17849, 2007, 1922, 3596, 3]}, "items": [{"id": "p_1804", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1805", "content": "nephrotoxicity [SEP] sts that pleiotropic effects of metformin can lessen gentamicin nephrotoxicity and improve mitochondrial homeostasis.", "tokenized_content": [2, 27880, 3, 16245, 1988, 20233, 2564, 1927, 11885, 2112, 2941, 1917, 17144, 27880, 1930, 3326, 4596, 7622, 18, 3]}, "items": [{"id": "p_1805", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1806", "content": "postoperative delirium [SEP] Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.", "tokenized_content": [2, 5924, 18166, 3, 15263, 6070, 2409, 6071, 8871, 1930, 1920, 2740, 1927, 5924, 18166, 1922, 7354, 2132, 7258, 7679, 7515, 5059, 18, 3]}, "items": [{"id": "p_1806", "content": "Postoperative Complications [SEP] Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which th", "score": 1, "type": null, "tokenized_content": [2, 5924, 5021, 3, 11896, 4028, 1988, 4081, 2132, 2256, 43, 4548, 4360, 18, 2611, 2278, 2014, 2278, 2084, 1998, 2712, 1942, 1920, 2573, 1958, 2154, 1913, 3]}]}
{"query": {"id": "q_1807", "content": "delirium [SEP] h during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.", "tokenized_content": [2, 18166, 3, 50, 2409, 6071, 8871, 1930, 1920, 2740, 1927, 5924, 18166, 1922, 7354, 2132, 7258, 7679, 7515, 5059, 18, 3]}, "items": [{"id": "p_1807", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_1808", "content": "hip fracture [SEP] opment of postoperative delirium in elderly patients undergoing hip fracture repair.", "tokenized_content": [2, 7679, 7515, 3, 2494, 2017, 1927, 5924, 18166, 1922, 7354, 2132, 7258, 7679, 7515, 5059, 18, 3]}, "items": [{"id": "p_1808", "content": "Hip Fractures [SEP] Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region.", "score": 1, "type": null, "tokenized_content": [2, 7679, 9018, 3, 9018, 1927, 1920, 14955, 4469, 31, 1920, 14955, 7467, 31, 12, 9550, 7467, 9018, 13, 31, 1920, 24517, 26150, 1036, 31, 2014, 1920, 2107, 17, 2014, 10356, 2694, 26150, 1935, 3031, 18, 3]}]}
{"query": {"id": "q_1809", "content": "hip fracture [SEP] ting intraoperative sedation depth during spinal anesthesia for hip fracture repair in elderly patients can decrease the prevalence of posto", "tokenized_content": [2, 7679, 7515, 3, 12347, 1029, 12122, 15263, 6070, 2409, 6071, 8871, 1958, 7679, 7515, 5059, 1922, 7354, 2132, 2112, 3714, 1920, 4077, 1927, 2753, 1037, 3]}, "items": [{"id": "p_1809", "content": "Hip Fractures [SEP] Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region.", "score": 1, "type": null, "tokenized_content": [2, 7679, 9018, 3, 9018, 1927, 1920, 14955, 4469, 31, 1920, 14955, 7467, 31, 12, 9550, 7467, 9018, 13, 31, 1920, 24517, 26150, 1036, 31, 2014, 1920, 2107, 17, 2014, 10356, 2694, 26150, 1935, 3031, 18, 3]}]}
{"query": {"id": "q_1810", "content": "postoperative delirium [SEP] cture repair in elderly patients can decrease the prevalence of postoperative delirium. PATIENTS AND METHODS: We performed a double-blind, randomized ", "tokenized_content": [2, 5924, 18166, 3, 3369, 2027, 5059, 1922, 7354, 2132, 2112, 3714, 1920, 4077, 1927, 5924, 18166, 18, 2132, 1930, 2860, 30, 2038, 2593, 43, 4825, 17, 7109, 16, 5542, 3]}, "items": [{"id": "p_1810", "content": "Postoperative Complications [SEP] Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which th", "score": 1, "type": null, "tokenized_content": [2, 5924, 5021, 3, 11896, 4028, 1988, 4081, 2132, 2256, 43, 4548, 4360, 18, 2611, 2278, 2014, 2278, 2084, 1998, 2712, 1942, 1920, 2573, 1958, 2154, 1913, 3]}]}
{"query": {"id": "q_1811", "content": "delirium [SEP] n elderly patients can decrease the prevalence of postoperative delirium. PATIENTS AND METHODS: We performed a double-blind, randomized ", "tokenized_content": [2, 18166, 3, 56, 7354, 2132, 2112, 3714, 1920, 4077, 1927, 5924, 18166, 18, 2132, 1930, 2860, 30, 2038, 2593, 43, 4825, 17, 7109, 16, 5542, 3]}, "items": [{"id": "p_1811", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_1812", "content": "dementia [SEP] patients (>or=65 years) without preoperative delirium or severe dementia who underwent hip fracture repair under spinal anesthesia with ", "tokenized_content": [2, 7811, 3, 2132, 12, 34, 2014, 33, 4459, 2739, 13, 2979, 8169, 18166, 2014, 4010, 7811, 2746, 5468, 7679, 7515, 5059, 2441, 6071, 8871, 1956, 3]}, "items": [{"id": "p_1812", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_1813", "content": "propofol [SEP]  who underwent hip fracture repair under spinal anesthesia with propofol sedation. Sedation depth was titrated using processed electroen", "tokenized_content": [2, 16615, 3, 2746, 5468, 7679, 7515, 5059, 2441, 6071, 8871, 1956, 16615, 15263, 18, 15263, 6070, 1982, 22861, 2193, 7078, 4260, 1917, 3]}, "items": [{"id": "p_1813", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_1814", "content": "Postoperative delirium [SEP] r deep (BIS, approximately 50) or light (BIS, >or=80) sedation. Postoperative delirium was assessed as defined by Diagnostic and Statistical Manual of", "tokenized_content": [2, 5924, 18166, 3, 60, 6515, 12, 7266, 16, 3993, 2761, 13, 2014, 3696, 12, 7266, 16, 34, 2014, 33, 3729, 13, 15263, 18, 5924, 18166, 1982, 3683, 1966, 3608, 2007, 3]}, "items": [{"id": "p_1814", "content": "Postoperative Complications [SEP] Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which th", "score": 1, "type": null, "tokenized_content": [2, 5924, 5021, 3, 11896, 4028, 1988, 4081, 2132, 2256, 43, 4548, 4360, 18, 2611, 2278, 2014, 2278, 2084, 1998, 2712, 1942, 1920, 2573, 1958, 2154, 1913, 3]}]}
{"query": {"id": "q_1815", "content": "Mental Disorders [SEP] was assessed as defined by Diagnostic and Statistical Manual of Mental Disorders (Third Edition Revised) criteria using the Confusion Assessment", "tokenized_content": [2, 5018, 4414, 3, 1982, 3683, 1966, 3608, 2007, 4785, 1930, 3850, 8507, 1927, 5018, 4414, 12, 4563, 17407, 10041, 13, 4164, 2193, 1920, 18272, 4076, 3]}, "items": [{"id": "p_1815", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1816", "content": "Sorafenib [SEP] Sorafenib-induced acute myocardial infarction due to coronary artery spas", "tokenized_content": [2, 16788, 3, 16788, 17, 2719, 3939, 6497, 8358, 2810, 1942, 5846, 5511, 19361, 1036, 3]}, "items": [{"id": "p_1816", "content": "sorafenib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16788, 3, 3]}]}
{"query": {"id": "q_1817", "content": "myocardial infarction [SEP] Sorafenib-induced acute myocardial infarction due to coronary artery spasm.", "tokenized_content": [2, 6497, 8358, 3, 16788, 17, 2719, 3939, 6497, 8358, 2810, 1942, 5846, 5511, 24431, 18, 3]}, "items": [{"id": "p_1817", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1818", "content": "coronary artery spasm [SEP] Sorafenib-induced acute myocardial infarction due to coronary artery spasm.", "tokenized_content": [2, 5846, 5511, 24431, 3, 16788, 17, 2719, 3939, 6497, 8358, 2810, 1942, 5846, 5511, 24431, 18, 3]}, "items": [{"id": "p_1818", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_1819", "content": "renal cell carcinoma [SEP] A 65-year-old man with advanced renal cell carcinoma was admitted due to continuing chest pain at rest. Two weeks be", "tokenized_content": [2, 4604, 2024, 5373, 3, 43, 4459, 17, 2476, 17, 4156, 2323, 1956, 5570, 4604, 2024, 5373, 1982, 9723, 2810, 1942, 14497, 8475, 3594, 2019, 6172, 18, 2288, 3625, 1998, 3]}, "items": [{"id": "p_1819", "content": "Carcinoma, Renal Cell [SEP] A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes includin", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 4604, 2024, 3, 43, 8538, 2210, 1927, 13088, 2014, 16321, 5373, 3595, 2037, 2094, 1927, 1920, 11770, 18, 2276, 2032, 2980, 8160, 2327, 1921, 3]}]}
{"query": {"id": "q_1820", "content": "chest pain [SEP] th advanced renal cell carcinoma was admitted due to continuing chest pain at rest. Two weeks before his admission, sorafenib had been sta", "tokenized_content": [2, 8475, 3594, 3, 1913, 5570, 4604, 2024, 5373, 1982, 9723, 2810, 1942, 14497, 8475, 3594, 2019, 6172, 18, 2288, 3625, 3119, 4167, 7682, 16, 16788, 2430, 2252, 23891, 3]}, "items": [{"id": "p_1820", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_1821", "content": "sorafenib [SEP]  continuing chest pain at rest. Two weeks before his admission, sorafenib had been started. He was diagnosed with non-ST-elevation myocar", "tokenized_content": [2, 16788, 3, 14497, 8475, 3594, 2019, 6172, 18, 2288, 3625, 3119, 4167, 7682, 16, 16788, 2430, 2252, 8074, 18, 2234, 1982, 5377, 1956, 2447, 17, 1955, 17, 8644, 15924, 15339, 3]}, "items": [{"id": "p_1821", "content": "sorafenib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16788, 3, 3]}]}
{"query": {"id": "q_1822", "content": "myocardial infarction [SEP] afenib had been started. He was diagnosed with non-ST-elevation myocardial infarction by laboratory data and electrocardiogram. Enhanced heart magnet", "tokenized_content": [2, 6497, 8358, 3, 2221, 28131, 1014, 2430, 2252, 8074, 18, 2234, 1982, 5377, 1956, 2447, 17, 1955, 17, 8644, 6497, 8358, 2007, 4542, 2230, 1930, 22477, 18, 4256, 4003, 14634, 3]}, "items": [{"id": "p_1822", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1823", "content": "subendocardial infarction [SEP] rdiogram. Enhanced heart magnetic resonance imaging also showed subendocardial infarction. However, there was no stenosis in coronary arteries on angiogr", "tokenized_content": [2, 2316, 2200, 9641, 1923, 8358, 3, 8695, 3940, 20087, 18, 4256, 4003, 5691, 6912, 3755, 2222, 2594, 2316, 2200, 9641, 1923, 8358, 18, 2406, 16, 2276, 1982, 2239, 10407, 1922, 3]}, "items": [{"id": "p_1823", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1824", "content": "Coronary artery spasm [SEP] ver, there was no stenosis in coronary arteries on angiography. Coronary artery spasm was induced by a provocative test. Cessation of sorafenib and a", "tokenized_content": [2, 5846, 5511, 24431, 3, 3566, 16, 2276, 1982, 2239, 10407, 1922, 5846, 9345, 1990, 11676, 18, 5846, 5511, 24431, 1982, 2719, 2007, 43, 2463, 21259, 2185, 2648, 18, 10975, 1927, 3]}, "items": [{"id": "p_1824", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_1825", "content": "Ca [SEP]  provocative test. Cessation of sorafenib and administration of Ca-channel blocker and nitrates ameliorated his symptoms, but rela", "tokenized_content": [2, 2332, 3, 2463, 21259, 2185, 2648, 18, 10975, 1927, 16788, 1930, 4183, 1927, 2332, 17, 4999, 14580, 1930, 12628, 1036, 22085, 4167, 3601, 16, 2308, 22247, 3]}, "items": [{"id": "p_1825", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1826", "content": "nitrates [SEP] ation of sorafenib and administration of Ca-channel blocker and nitrates ameliorated his symptoms, but relapse occurred after resumption", "tokenized_content": [2, 12628, 1036, 3, 2019, 2001, 1927, 16788, 1930, 4183, 1927, 2332, 17, 4999, 14580, 1930, 12628, 1036, 22085, 4167, 3601, 16, 2308, 8834, 4807, 2256, 22380, 2929, 3]}, "items": [{"id": "p_1826", "content": "Nitrates [SEP] Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12628, 1036, 3, 13849, 2014, 6805, 16028, 1930, 16785, 1927, 10233, 2687, 18, 2144, 4300, 5531, 1920, 20112, 17, 6917, 18, 3]}]}
{"query": {"id": "q_1827", "content": "nicorandil [SEP] elapse occurred after resumption of sorafenib. Addition of oral nicorandil reduced his symptoms and maintained stable angina status. We re", "tokenized_content": [2, 7718, 17182, 7408, 1024, 3, 2349, 6126, 4807, 2256, 22380, 2929, 1927, 16788, 18, 2459, 1927, 4726, 7718, 17182, 7408, 1024, 3028, 4167, 3601, 1930, 5514, 4700, 16961, 3642, 18, 3]}, "items": [{"id": "p_1827", "content": "Nicorandil [SEP] A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that cau", "score": 1, "type": null, "tokenized_content": [2, 7718, 17182, 7408, 1024, 3, 43, 10533, 1927, 1920, 21946, 3665, 5482, 1988, 1977, 12171, 4252, 1956, 1925, 6805, 12628, 18, 2176, 1977, 43, 9057, 17, 4999, 4437, 1915, 1988, 20200, 3]}]}
{"query": {"id": "q_1828", "content": "stable angina [SEP] Addition of oral nicorandil reduced his symptoms and maintained stable angina status. We report the first case of sorafenib-induced coronary ", "tokenized_content": [2, 4700, 16961, 3, 2459, 1927, 4726, 7718, 17182, 7408, 1024, 3028, 4167, 3601, 1930, 5514, 4700, 16961, 3642, 18, 2038, 3809, 1920, 2561, 3087, 1927, 16788, 17, 2719, 5846, 3]}, "items": [{"id": "p_1828", "content": "Angina, Stable [SEP] Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such ", "score": 1, "type": null, "tokenized_content": [2, 16961, 16, 4700, 3, 7733, 1930, 13257, 8475, 15335, 5394, 14019, 2007, 43, 3841, 28187, 1988, 18772, 2209, 4073, 10975, 1927, 2427, 3]}]}
{"query": {"id": "q_1829", "content": "coronary artery spasm [SEP] le angina status. We report the first case of sorafenib-induced coronary artery spasm. Sorafenib is a multikinase inhibitor that targets signaling pa", "tokenized_content": [2, 5846, 5511, 24431, 3, 2071, 16961, 3642, 18, 2038, 3809, 1920, 2561, 3087, 1927, 16788, 17, 2719, 5846, 5511, 24431, 18, 16788, 1977, 43, 2779, 25545, 4106, 1988, 4845, 3197, 3]}, "items": [{"id": "p_1829", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_1830", "content": "Sorafenib [SEP] port the first case of sorafenib-induced coronary artery spasm. Sorafenib is a multikinase inhibitor that targets signaling pathways nece", "tokenized_content": [2, 16788, 3, 9260, 1920, 2561, 3087, 1927, 16788, 17, 2719, 5846, 5511, 24431, 18, 16788, 1977, 43, 2779, 25545, 4106, 1988, 4845, 3197, 3873, 3296, 1021, 3]}, "items": [{"id": "p_1830", "content": "sorafenib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16788, 3, 3]}]}
{"query": {"id": "q_1831", "content": "ciprofloxacin [SEP] Anxiogenic potential of ciprofloxacin and norfloxacin in rats.", "tokenized_content": [2, 18502, 3, 24400, 3880, 2889, 1927, 18502, 1930, 3990, 14217, 1922, 3615, 18, 3]}, "items": [{"id": "p_1831", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_1832", "content": "norfloxacin [SEP] Anxiogenic potential of ciprofloxacin and norfloxacin in rats.", "tokenized_content": [2, 3990, 14217, 3, 24400, 3880, 2889, 1927, 18502, 1930, 3990, 14217, 1922, 3615, 18, 3]}, "items": [{"id": "p_1832", "content": "Norfloxacin [SEP] A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-po", "score": 1, "type": null, "tokenized_content": [2, 3990, 14217, 3, 43, 6830, 23619, 13048, 12, 23619, 24909, 13, 1956, 4949, 17, 5648, 13021, 2455, 3316, 2501, 8604, 17, 3136, 1930, 8604, 17, 2510, 3]}]}
{"query": {"id": "q_1833", "content": "fluoroquinolones [SEP] INTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adu", "tokenized_content": [2, 23619, 24909, 3, 6935, 30, 1920, 3216, 24400, 3880, 2564, 1927, 23619, 24909, 16, 8129, 18502, 1930, 3990, 14217, 16, 1985, 3845, 1922, 2041, 1032, 3]}, "items": [{"id": "p_1833", "content": "Fluoroquinolones [SEP] A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23619, 24909, 3, 43, 2210, 1927, 9012, 24909, 1956, 2019, 3464, 2340, 29700, 6761, 1930, 43, 16057, 25823, 2199, 2210, 18, 3]}]}
{"query": {"id": "q_1834", "content": "ciprofloxacin [SEP] ON: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albi", "tokenized_content": [2, 18502, 3, 1990, 30, 1920, 3216, 24400, 3880, 2564, 1927, 23619, 24909, 16, 8129, 18502, 1930, 3990, 14217, 16, 1985, 3845, 1922, 4160, 19134, 12449, 5311, 1033, 3]}, "items": [{"id": "p_1834", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_1835", "content": "norfloxacin [SEP] nxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of eithe", "tokenized_content": [2, 3990, 14217, 3, 27578, 3940, 11216, 2564, 1927, 23619, 24909, 16, 8129, 18502, 1930, 3990, 14217, 16, 1985, 3845, 1922, 4160, 19134, 12449, 28734, 3615, 1927, 16101, 20536, 3]}, "items": [{"id": "p_1835", "content": "Norfloxacin [SEP] A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-po", "score": 1, "type": null, "tokenized_content": [2, 3990, 14217, 3, 43, 6830, 23619, 13048, 12, 23619, 24909, 13, 1956, 4949, 17, 5648, 13021, 2455, 3316, 2501, 8604, 17, 3136, 1930, 8604, 17, 2510, 3]}]}
{"query": {"id": "q_1836", "content": "anxious behaviour [SEP] ndicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. Ho", "tokenized_content": [2, 19719, 6270, 3, 8026, 14494, 1988, 18502, 17, 1930, 3990, 14217, 17, 2868, 3615, 2594, 19719, 6270, 1922, 3723, 1942, 2285, 3615, 1922, 2136, 1920, 3673, 3942, 18, 6673, 3]}, "items": [{"id": "p_1836", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_1837", "content": "AZT [SEP] Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy.", "tokenized_content": [2, 28301, 3, 6497, 4557, 5207, 2294, 4041, 6461, 1942, 28301, 17, 2719, 14141, 18, 3]}, "items": [{"id": "p_1837", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1838", "content": "cardiomyopathy [SEP] l Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy.", "tokenized_content": [2, 14141, 3, 54, 4557, 5207, 2294, 4041, 6461, 1942, 28301, 17, 2719, 14141, 18, 3]}, "items": [{"id": "p_1838", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1839", "content": "Dilated cardiomyopathy [SEP] BACKGROUND: Dilated cardiomyopathy (DCM) and myocarditis occur in many HIV-infected individuals, r", "tokenized_content": [2, 16434, 14141, 3, 3872, 30, 16434, 14141, 12, 16327, 13, 1930, 27169, 4704, 1922, 3086, 3525, 17, 4014, 3445, 16, 60, 3]}, "items": [{"id": "p_1839", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_1840", "content": "DCM [SEP] BACKGROUND: Dilated cardiomyopathy (DCM) and myocarditis occur in many HIV-infected individuals, result", "tokenized_content": [2, 16327, 3, 3872, 30, 16434, 14141, 12, 16327, 13, 1930, 27169, 4704, 1922, 3086, 3525, 17, 4014, 3445, 16, 3211, 3]}, "items": [{"id": "p_1840", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_1841", "content": "myocarditis [SEP] BACKGROUND: Dilated cardiomyopathy (DCM) and myocarditis occur in many HIV-infected individuals, resulting in symptomati", "tokenized_content": [2, 27169, 3, 3872, 30, 16434, 14141, 12, 16327, 13, 1930, 27169, 4704, 1922, 3086, 3525, 17, 4014, 3445, 16, 3864, 1922, 3226, 1968, 3]}, "items": [{"id": "p_1841", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1842", "content": "HIV-infected [SEP] UND: Dilated cardiomyopathy (DCM) and myocarditis occur in many HIV-infected individuals, resulting in symptomatic heart failure in up to 5%", "tokenized_content": [2, 3525, 17, 4014, 3, 3075, 30, 16434, 14141, 12, 16327, 13, 1930, 27169, 4704, 1922, 3086, 3525, 17, 4014, 3445, 16, 3864, 1922, 9371, 4003, 4574, 1922, 2353, 1942, 25, 3]}, "items": [{"id": "p_1842", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_1843", "content": "heart failure [SEP] ccur in many HIV-infected individuals, resulting in symptomatic heart failure in up to 5% of patients. Highly active antiretroviral therapy (", "tokenized_content": [2, 4003, 4574, 3, 4928, 1949, 1922, 3086, 3525, 17, 4014, 3445, 16, 3864, 1922, 9371, 4003, 4574, 1922, 2353, 1942, 25, 9, 1927, 2132, 18, 3626, 3500, 14255, 3181, 12, 3]}, "items": [{"id": "p_1843", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1844", "content": "acquired immunodeficiency syndrome [SEP] py (HAART) has significantly reduced morbidity and mortality of acquired immunodeficiency syndrome (AIDS), but has resulted in an increase in cardiac and skeletal", "tokenized_content": [2, 5815, 13141, 4741, 3, 6085, 12, 18711, 13, 2258, 2567, 3028, 7207, 1930, 3885, 1927, 5815, 13141, 4741, 12, 8494, 13, 16, 2308, 2258, 4306, 1922, 1925, 2760, 1922, 4435, 3]}, "items": [{"id": "p_1844", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_1845", "content": "AIDS [SEP]  morbidity and mortality of acquired immunodeficiency syndrome (AIDS), but has resulted in an increase in cardiac and skeletal myopa", "tokenized_content": [2, 8494, 3, 7207, 1930, 3885, 1927, 5815, 13141, 4741, 12, 8494, 13, 16, 2308, 2258, 4306, 1922, 1925, 2760, 1922, 4435, 1930, 7345, 15924, 4302, 3]}, "items": [{"id": "p_1845", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_1846", "content": "cardiac and skeletal myopathies [SEP] odeficiency syndrome (AIDS), but has resulted in an increase in cardiac and skeletal myopathies. METHODS AND RESULTS: In order to investigate whether the HAART", "tokenized_content": [2, 4435, 1930, 7345, 15924, 9112, 2062, 3, 4426, 7726, 3792, 4741, 12, 8494, 13, 16, 2308, 2258, 4306, 1922, 1925, 2760, 1922, 4435, 1930, 7345, 15924, 9112, 2062, 18, 2860, 3]}, "items": [{"id": "p_1846", "content": "Dilated cardiomyopathy, neutropenia, skeletal myopathy, and abnormal mitochondria [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16434, 14141, 16, 18005, 16, 7345, 25017, 16, 1930, 4552, 6489, 3, 3]}]}
{"query": {"id": "q_1847", "content": "zidovudine [SEP] ND RESULTS: In order to investigate whether the HAART component zidovudine (3'-azido-2',3'-deoxythymidine; AZT) triggers the Fas-dependent", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 8026, 2274, 30, 1922, 3238, 1942, 4482, 3053, 1920, 18711, 4594, 28666, 22389, 1020, 20597, 12, 23, 11, 17, 6352, 15072, 17, 22, 11, 16, 3]}, "items": [{"id": "p_1847", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1848", "content": "3'-azido-2',3'-deoxythymidine [SEP] In order to investigate whether the HAART component zidovudine (3'-azido-2',3'-deoxythymidine; AZT) triggers the Fas-dependent cell-death pathway and cause c", "tokenized_content": [2, 23, 11, 17, 6352, 15072, 17, 22, 11, 16, 23, 11, 17, 16333, 28935, 16408, 2053, 3, 1922, 3238, 1942, 4482, 3053, 1920, 18711, 4594, 28666, 22389, 1020, 20597, 12, 3]}, "items": [{"id": "p_1848", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1849", "content": "AZT [SEP]  the HAART component zidovudine (3'-azido-2',3'-deoxythymidine; AZT) triggers the Fas-dependent cell-death pathway and cause cytosk", "tokenized_content": [2, 28301, 3, 1920, 18711, 4594, 28666, 22389, 1020, 20597, 12, 23, 11, 17, 6352, 15072, 17, 22, 11, 16, 23, 11, 17, 16333, 28935, 16408, 2053, 31, 28301, 13, 11847, 3]}, "items": [{"id": "p_1849", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1850", "content": "cardiac dilation [SEP] re or function. In contrast, AZT-treated FasL Tg mice developed cardiac dilation and depressed cardiac function in a dose-dependent manner, with", "tokenized_content": [2, 4435, 16470, 3, 1964, 2014, 2347, 18, 1922, 3320, 16, 28301, 17, 2868, 21819, 6030, 2518, 3530, 4435, 16470, 1930, 11365, 4435, 2347, 1922, 43, 3253, 17, 3100, 5222, 16, 3]}, "items": [{"id": "p_1850", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_1851", "content": "cardiomyopathy [SEP] BACKGROUND: Dilated cardiomyopathy (DCM) and myocarditis occur in many HIV-infected individuals, r", "tokenized_content": [2, 14141, 3, 3872, 30, 16434, 14141, 12, 16327, 13, 1930, 27169, 4704, 1922, 3086, 3525, 17, 4014, 3445, 16, 60, 3]}, "items": [{"id": "p_1851", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1852", "content": "Valproate [SEP] Valproate-induced chorea and encephalopathy in atypical nonketotic hyperg", "tokenized_content": [2, 23867, 2010, 3, 23867, 2010, 17, 2719, 11418, 5376, 1930, 19393, 1922, 10834, 2447, 18540, 3153, 11602, 3]}, "items": [{"id": "p_1852", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1853", "content": "chorea [SEP] Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia.", "tokenized_content": [2, 11418, 5376, 3, 23867, 2010, 17, 2719, 11418, 5376, 1930, 19393, 1922, 10834, 2447, 18540, 3153, 11903, 11388, 6026, 18, 3]}, "items": [{"id": "p_1853", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_1854", "content": "encephalopathy [SEP] Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia.", "tokenized_content": [2, 19393, 3, 23867, 2010, 17, 2719, 11418, 5376, 1930, 19393, 1922, 10834, 2447, 18540, 3153, 11903, 11388, 6026, 18, 3]}, "items": [{"id": "p_1854", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_1855", "content": "nonketotic hyperglycinemia [SEP] Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia.", "tokenized_content": [2, 2447, 18540, 3153, 11903, 11388, 6026, 3, 23867, 2010, 17, 2719, 11418, 5376, 1930, 19393, 1922, 10834, 2447, 18540, 3153, 11903, 11388, 6026, 18, 3]}, "items": [{"id": "p_1855", "content": "Hyperglycinemia, Nonketotic [SEP] An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11903, 11388, 6026, 16, 2447, 18540, 3153, 3, 1925, 13027, 13992, 4487, 4770, 4189, 2007, 16148, 1922, 1920, 4596, 10646, 6404, 2433, 18, 3]}]}
{"query": {"id": "q_1856", "content": "Nonketotic hyperglycinemia [SEP] Nonketotic hyperglycinemia is a disorder of amino acid metabolism in which a defect in the", "tokenized_content": [2, 2447, 18540, 3153, 11903, 11388, 6026, 3, 2447, 18540, 3153, 11903, 11388, 6026, 1977, 43, 4770, 1927, 3835, 2687, 4714, 1922, 2154, 43, 7374, 1922, 1920, 3]}, "items": [{"id": "p_1856", "content": "Hyperglycinemia, Nonketotic [SEP] An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11903, 11388, 6026, 16, 2447, 18540, 3153, 3, 1925, 13027, 13992, 4487, 4770, 4189, 2007, 16148, 1922, 1920, 4596, 10646, 6404, 2433, 18, 3]}]}
{"query": {"id": "q_1857", "content": "disorder of amino acid metabolism [SEP] Nonketotic hyperglycinemia is a disorder of amino acid metabolism in which a defect in the glycine cleavage system leads to an ac", "tokenized_content": [2, 4770, 1927, 3835, 2687, 4714, 3, 2447, 18540, 3153, 11903, 11388, 6026, 1977, 43, 4770, 1927, 3835, 2687, 4714, 1922, 2154, 43, 7374, 1922, 1920, 10646, 6404, 2433, 5029, 1942, 3]}, "items": [{"id": "p_1857", "content": "Amino Acid Metabolism, Inborn Errors [SEP] Disorders affecting amino acid metabolism. The majority of these disorders are inherited and present in the neonatal period with", "score": 1, "type": null, "tokenized_content": [2, 3835, 2687, 4714, 16, 1922, 23419, 6109, 3, 4414, 7359, 3835, 2687, 4714, 18, 1920, 4827, 1927, 2144, 4414, 2032, 12911, 1930, 2481, 1922, 1920, 7985, 3047, 1956, 3]}]}
{"query": {"id": "q_1858", "content": "glycine [SEP] Nonketotic hyperglycinemia is a disorder of amino acid metabolism in which a defect in ", "tokenized_content": [2, 10646, 3, 2447, 18540, 3153, 11903, 11388, 6026, 1977, 43, 4770, 1927, 3835, 2687, 4714, 1922, 2154, 43, 7374, 1922, 3]}, "items": [{"id": "p_1858", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_1859", "content": "apnea [SEP] ody compartments. In the classical form it presents as neonatal apnea, intractable seizures, and hypotonia, followed by significant p", "tokenized_content": [2, 17578, 3, 4426, 1012, 10436, 18, 1922, 1920, 8445, 2386, 2176, 8178, 1966, 7985, 17578, 16, 26032, 10060, 16, 1930, 12201, 6114, 16, 3489, 2007, 2228, 58, 3]}, "items": [{"id": "p_1859", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_1860", "content": "seizures [SEP] n the classical form it presents as neonatal apnea, intractable seizures, and hypotonia, followed by significant psychomotor retardation", "tokenized_content": [2, 10060, 3, 56, 1920, 8445, 2386, 2176, 8178, 1966, 7985, 17578, 16, 26032, 10060, 16, 1930, 12201, 6114, 16, 3489, 2007, 2228, 26261, 16342, 3]}, "items": [{"id": "p_1860", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1861", "content": "hypotonia [SEP] l form it presents as neonatal apnea, intractable seizures, and hypotonia, followed by significant psychomotor retardation. An important ", "tokenized_content": [2, 12201, 6114, 3, 54, 2386, 2176, 8178, 1966, 7985, 17578, 16, 26032, 10060, 16, 1930, 12201, 6114, 16, 3489, 2007, 2228, 26261, 16342, 18, 1925, 2715, 3]}, "items": [{"id": "p_1861", "content": "Muscle Hypotonia [SEP] A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3760, 12201, 6114, 3, 43, 7798, 2306, 1927, 1920, 7345, 3760, 11020, 4961, 2007, 43, 9597, 3554, 1942, 9832, 15192, 18, 3]}]}
{"query": {"id": "q_1862", "content": "psychomotor retardation [SEP] a, intractable seizures, and hypotonia, followed by significant psychomotor retardation. An important subset of children with nonketotic hyperglycinemi", "tokenized_content": [2, 26261, 16342, 3, 43, 16, 26032, 10060, 16, 1930, 12201, 6114, 16, 3489, 2007, 2228, 26261, 16342, 18, 1925, 2715, 6728, 1927, 3069, 1956, 2447, 18540, 3153, 11903, 11388, 7395, 3]}, "items": [{"id": "p_1862", "content": "Psychomotor Disorders [SEP] Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26261, 4414, 3, 6754, 1927, 4842, 2347, 1988, 2032, 2458, 1956, 6805, 1930, 2447, 17, 6805, 4328, 4414, 18, 3]}]}
{"query": {"id": "q_1863", "content": "nonketotic hyperglycinemia [SEP] t psychomotor retardation. An important subset of children with nonketotic hyperglycinemia are atypical variants who present in a heterogeneous manner. Th", "tokenized_content": [2, 2447, 18540, 3153, 11903, 11388, 6026, 3, 62, 26261, 16342, 18, 1925, 2715, 6728, 1927, 3069, 1956, 2447, 18540, 3153, 11903, 11388, 6026, 2032, 10834, 4936, 2746, 2481, 1922, 43, 3]}, "items": [{"id": "p_1863", "content": "Hyperglycinemia, Nonketotic [SEP] An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11903, 11388, 6026, 16, 2447, 18540, 3153, 3, 1925, 13027, 13992, 4487, 4770, 4189, 2007, 16148, 1922, 1920, 4596, 10646, 6404, 2433, 18, 3]}]}
{"query": {"id": "q_1864", "content": "language delay [SEP] heterogeneous manner. This report describes a patient with mild language delay and mental retardation, who was found to have nonketotic hyperg", "tokenized_content": [2, 6357, 4989, 3, 8538, 5222, 18, 2052, 3809, 9845, 43, 2774, 1956, 5809, 6357, 4989, 1930, 5018, 16342, 16, 2746, 1982, 2435, 1942, 2162, 2447, 18540, 3153, 11602, 3]}, "items": [{"id": "p_1864", "content": "Language Development Disorders [SEP] Conditions characterized by language abilities (comprehension and expression of speech and writing) that are below the expected ", "score": 1, "type": null, "tokenized_content": [2, 6357, 2740, 4414, 3, 2961, 4378, 2007, 6357, 10957, 12, 15538, 1930, 2294, 1927, 8560, 1930, 9095, 13, 1988, 2032, 4535, 1920, 4100, 3]}]}
{"query": {"id": "q_1865", "content": "mental retardation [SEP] r. This report describes a patient with mild language delay and mental retardation, who was found to have nonketotic hyperglycinemia following her", "tokenized_content": [2, 5018, 16342, 3, 60, 18, 2052, 3809, 9845, 43, 2774, 1956, 5809, 6357, 4989, 1930, 5018, 16342, 16, 2746, 1982, 2435, 1942, 2162, 2447, 18540, 3153, 11903, 11388, 6026, 2894, 3]}, "items": [{"id": "p_1865", "content": "Intellectual Disability [SEP] Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, inc", "score": 1, "type": null, "tokenized_content": [2, 13059, 8015, 3, 28843, 2620, 13059, 7295, 2154, 22970, 2409, 1920, 5878, 3047, 18, 2052, 2258, 3137, 2889, 22608, 16, 2043, 3]}]}
{"query": {"id": "q_1866", "content": "encephalopathy [SEP] onketotic hyperglycinemia following her presentation with acute encephalopathy and chorea shortly after initiation of valproate therapy.", "tokenized_content": [2, 19393, 3, 1990, 18540, 3153, 11903, 11388, 6026, 2894, 3656, 6544, 1956, 3939, 19393, 1930, 11418, 5376, 17002, 2256, 6035, 1927, 23867, 2010, 3181, 18, 3]}, "items": [{"id": "p_1866", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_1867", "content": "chorea [SEP] inemia following her presentation with acute encephalopathy and chorea shortly after initiation of valproate therapy.", "tokenized_content": [2, 11418, 5376, 3, 11116, 6026, 2894, 3656, 6544, 1956, 3939, 19393, 1930, 11418, 5376, 17002, 2256, 6035, 1927, 23867, 2010, 3181, 18, 3]}, "items": [{"id": "p_1867", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_1868", "content": "valproate [SEP] ith acute encephalopathy and chorea shortly after initiation of valproate therapy.", "tokenized_content": [2, 23867, 2010, 3, 24737, 3939, 19393, 1930, 11418, 5376, 17002, 2256, 6035, 1927, 23867, 2010, 3181, 18, 3]}, "items": [{"id": "p_1868", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1869", "content": "ritanserin [SEP] Microinjection of ritanserin into the CA1 region of hippocampus improves scopolamine-induced", "tokenized_content": [2, 24019, 2075, 16654, 3, 24283, 1927, 24019, 2075, 16654, 2460, 1920, 12961, 3031, 1927, 7661, 10204, 25392, 10173, 25157, 17, 2719, 3]}, "items": [{"id": "p_1869", "content": "Ritanserin [SEP] A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety an", "score": 1, "type": null, "tokenized_content": [2, 24019, 2075, 16654, 3, 43, 5328, 1930, 6828, 11153, 17, 22, 8151, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 43, 5386, 1927, 12688, 2712, 1942, 5592, 1925, 3]}]}
{"query": {"id": "q_1870", "content": "scopolamine [SEP] ction of ritanserin into the CA1 region of hippocampus improves scopolamine-induced amnesia in adult male rats.", "tokenized_content": [2, 25392, 10173, 25157, 3, 3369, 2001, 1927, 24019, 2075, 16654, 2460, 1920, 12961, 3031, 1927, 7661, 10204, 25392, 10173, 25157, 17, 2719, 14701, 7156, 1922, 4160, 4005, 3615, 18, 3]}, "items": [{"id": "p_1870", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_1871", "content": "amnesia [SEP] into the CA1 region of hippocampus improves scopolamine-induced amnesia in adult male rats.", "tokenized_content": [2, 14701, 7156, 3, 2460, 1920, 12961, 3031, 1927, 7661, 10204, 25392, 10173, 25157, 17, 2719, 14701, 7156, 1922, 4160, 4005, 3615, 18, 3]}, "items": [{"id": "p_1871", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_1872", "content": "ritanserin [SEP] The effect of ritanserin (5-HT2 antagonist) on scopolamine (muscarinic cholinergic antag", "tokenized_content": [2, 24019, 2075, 16654, 3, 1920, 2495, 1927, 24019, 2075, 16654, 12, 25, 17, 5334, 1028, 8151, 13, 1990, 25392, 10173, 25157, 12, 20318, 13908, 4942, 2006, 3]}, "items": [{"id": "p_1872", "content": "Ritanserin [SEP] A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety an", "score": 1, "type": null, "tokenized_content": [2, 24019, 2075, 16654, 3, 43, 5328, 1930, 6828, 11153, 17, 22, 8151, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 43, 5386, 1927, 12688, 2712, 1942, 5592, 1925, 3]}]}
{"query": {"id": "q_1873", "content": "scopolamine [SEP] The effect of ritanserin (5-HT2 antagonist) on scopolamine (muscarinic cholinergic antagonist)-induced amnesia in Morris w", "tokenized_content": [2, 25392, 10173, 25157, 3, 1920, 2495, 1927, 24019, 2075, 16654, 12, 25, 17, 5334, 1028, 8151, 13, 1990, 25392, 10173, 25157, 12, 20318, 13908, 8151, 13, 17, 2719, 14701, 7156, 3]}, "items": [{"id": "p_1873", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_1874", "content": "amnesia [SEP] ist) on scopolamine (muscarinic cholinergic antagonist)-induced amnesia in Morris water maze (MWM) was investigated. Rats were divided ", "tokenized_content": [2, 14701, 7156, 3, 1977, 1031, 13, 1990, 25392, 10173, 25157, 12, 20318, 13908, 8151, 13, 17, 2719, 14701, 7156, 1922, 20376, 3224, 14476, 12, 8825, 1035, 13, 1982, 3845, 18, 3]}, "items": [{"id": "p_1874", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_1875", "content": "DMSO [SEP] pus. One week later, they received repeatedly vehicles (saline, DMSO, saline+DMSO), scopolamine (2 microg/0.5 microl saline/side; 30", "tokenized_content": [2, 7731, 3, 24093, 18, 2340, 2982, 3690, 16, 2611, 4004, 14959, 18488, 12, 5977, 16, 7731, 16, 5977, 15, 7731, 13, 16, 25392, 10173, 25157, 12, 22, 12517, 19, 20, 3]}, "items": [{"id": "p_1875", "content": "Dimethyl Sulfoxide [SEP] A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membran", "score": 1, "type": null, "tokenized_content": [2, 9780, 20139, 3, 43, 3626, 5676, 6805, 5875, 16, 1988, 1977, 2251, 5673, 1966, 43, 4399, 7596, 18, 2882, 1927, 2496, 3682, 1942, 21224, 3933, 3033, 1928, 3]}]}
{"query": {"id": "q_1876", "content": "Ritanserin [SEP] tform in scopolamine-treated group as compared to saline group. Ritanserin-treated rats (4 microg/0.5 microl/side) showed a significant de", "tokenized_content": [2, 24019, 2075, 16654, 3, 6406, 2076, 1922, 25392, 10173, 25157, 17, 2868, 2210, 1966, 2452, 1942, 5977, 2210, 18, 24019, 2075, 16654, 17, 2868, 3615, 12, 24, 12517, 19, 20, 3]}, "items": [{"id": "p_1876", "content": "Ritanserin [SEP] A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety an", "score": 1, "type": null, "tokenized_content": [2, 24019, 2075, 16654, 3, 43, 5328, 1930, 6828, 11153, 17, 22, 8151, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 43, 5386, 1927, 12688, 2712, 1942, 5592, 1925, 3]}]}
{"query": {"id": "q_1877", "content": "Hypoxia [SEP] Hypoxia in renal disease with proteinuria and/or glomerular hypertensio", "tokenized_content": [2, 7264, 3, 7264, 1922, 4604, 2573, 1956, 15831, 1930, 19, 2014, 11655, 4506, 2099, 3940, 3]}, "items": [{"id": "p_1877", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_1878", "content": "renal disease [SEP] Hypoxia in renal disease with proteinuria and/or glomerular hypertension.", "tokenized_content": [2, 4604, 2573, 3, 7264, 1922, 4604, 2573, 1956, 15831, 1930, 19, 2014, 11655, 5579, 18, 3]}, "items": [{"id": "p_1878", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1879", "content": "proteinuria [SEP] Hypoxia in renal disease with proteinuria and/or glomerular hypertension.", "tokenized_content": [2, 15831, 3, 7264, 1922, 4604, 2573, 1956, 15831, 1930, 19, 2014, 11655, 5579, 18, 3]}, "items": [{"id": "p_1879", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1880", "content": "hypertension [SEP] Hypoxia in renal disease with proteinuria and/or glomerular hypertension.", "tokenized_content": [2, 5579, 3, 7264, 1922, 4604, 2573, 1956, 15831, 1930, 19, 2014, 11655, 5579, 18, 3]}, "items": [{"id": "p_1880", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1881", "content": "hypoxia [SEP]  methods have been available. In this study, we developed a new hypoxia-responsive reporter vector using a hypoxia-responsive element o", "tokenized_content": [2, 7264, 3, 2860, 2162, 2252, 3322, 18, 1922, 2052, 2161, 16, 2038, 3530, 43, 2814, 7264, 17, 8487, 6734, 4580, 2193, 43, 7264, 17, 8487, 6149, 57, 3]}, "items": [{"id": "p_1881", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_1882", "content": "diseased kidney [SEP] mal model to the detection of tubulointerstitial hypoxia in the diseased kidney. With this model, we were able to identify diffuse cortical hyp", "tokenized_content": [2, 16663, 5245, 3, 3054, 2322, 1942, 1920, 3805, 1927, 25860, 4418, 2045, 2572, 2086, 7264, 1922, 1920, 16663, 5245, 18, 1956, 2052, 2322, 16, 2038, 1985, 4236, 1942, 3512, 9435, 3]}, "items": [{"id": "p_1882", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1883", "content": "puromycin aminonucleoside [SEP] model, we were able to identify diffuse cortical hypoxia in the puromycin aminonucleoside-induced nephrotic syndrome and focal and segmental hypoxia in t", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 2322, 16, 2038, 1985, 4236, 1942, 3512, 9435, 5586, 7264, 1922, 1920, 19750, 3835, 1022, 2626, 8028, 17, 2719, 29646, 4741, 1930, 8083, 1930, 3]}, "items": [{"id": "p_1883", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_1884", "content": "nephrotic syndrome [SEP] ffuse cortical hypoxia in the puromycin aminonucleoside-induced nephrotic syndrome and focal and segmental hypoxia in the remnant kidney model. Ex", "tokenized_content": [2, 29646, 4741, 3, 10735, 2517, 5586, 7264, 1922, 1920, 19750, 3835, 1022, 2626, 8028, 17, 2719, 29646, 4741, 1930, 8083, 1930, 16294, 7264, 1922, 1920, 23537, 5245, 2322, 18, 1975, 3]}, "items": [{"id": "p_1884", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_1885", "content": "hypoxic [SEP] itive, and terminal dUTP nick-end labeled-positive cells in the hypoxic cortical area in the remnant kidney model. We propose here a po", "tokenized_content": [2, 11277, 3, 2176, 2320, 16, 1930, 4262, 28024, 12657, 17, 2482, 4993, 17, 2843, 2094, 1922, 1920, 11277, 5586, 3403, 1922, 1920, 23537, 5245, 2322, 18, 2038, 8040, 3410, 43, 3]}, "items": [{"id": "p_1885", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_1886", "content": "glomerular diseases [SEP]  tie between chronic tubulointerstitial hypoxia and progressive glomerular diseases.", "tokenized_content": [2, 11655, 3902, 3, 19108, 2192, 3724, 25860, 4418, 2045, 2572, 2086, 7264, 1930, 7529, 11655, 3902, 18, 3]}, "items": [{"id": "p_1886", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1887", "content": "cardiotoxicity [SEP] Consensus statement concerning cardiotoxicity occurring during haematopoietic stem cell transplantation in th", "tokenized_content": [2, 30490, 3, 7076, 12977, 8679, 30490, 6966, 2409, 13080, 9251, 4402, 2024, 6530, 1922, 1913, 3]}, "items": [{"id": "p_1887", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_1888", "content": "autoimmune diseases [SEP] ng haematopoietic stem cell transplantation in the treatment of autoimmune diseases, with special reference to systemic sclerosis and multiple scle", "tokenized_content": [2, 8904, 3902, 3, 4375, 13080, 9251, 4402, 2024, 6530, 1922, 1920, 2311, 1927, 8904, 3902, 16, 1956, 5180, 4386, 1942, 5510, 11484, 1930, 3137, 22305, 1021, 3]}, "items": [{"id": "p_1888", "content": "Autoimmune Diseases [SEP] Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are ", "score": 1, "type": null, "tokenized_content": [2, 8904, 3902, 3, 4414, 1988, 2032, 4378, 2007, 1920, 3372, 1927, 3788, 1988, 9793, 1956, 4423, 3878, 2014, 3743, 7917, 2094, 1988, 2032, 3]}]}
{"query": {"id": "q_1889", "content": "systemic sclerosis [SEP] the treatment of autoimmune diseases, with special reference to systemic sclerosis and multiple sclerosis.", "tokenized_content": [2, 5510, 11484, 3, 1920, 2311, 1927, 8904, 3902, 16, 1956, 5180, 4386, 1942, 5510, 11484, 1930, 3137, 11484, 18, 3]}, "items": [{"id": "p_1889", "content": "Scleroderma, Systemic [SEP] A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GA", "score": 1, "type": null, "tokenized_content": [2, 8266, 20532, 16, 5510, 3, 43, 3724, 2779, 17, 2433, 4770, 1927, 14948, 2960, 18, 2176, 1977, 4378, 2007, 11484, 1922, 1920, 4407, 16, 1920, 9193, 16, 1920, 4003, 16, 1920, 4357, 3]}]}
{"query": {"id": "q_1890", "content": "multiple sclerosis [SEP] mune diseases, with special reference to systemic sclerosis and multiple sclerosis.", "tokenized_content": [2, 3137, 11484, 3, 10965, 1021, 3902, 16, 1956, 5180, 4386, 1942, 5510, 11484, 1930, 3137, 11484, 18, 3]}, "items": [{"id": "p_1890", "content": "Multiple Sclerosis [SEP] An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. P", "score": 1, "type": null, "tokenized_content": [2, 3137, 11484, 3, 1925, 8904, 4770, 4994, 7359, 4201, 4440, 1930, 4378, 2007, 12102, 1927, 12996, 1922, 1920, 4101, 7580, 2433, 18, 58, 3]}]}
{"query": {"id": "q_1891", "content": "autoimmune diseases [SEP] sible and effective treatment for selected patients with severe autoimmune diseases. Worldwide, over 650 patients have been transplanted in the con", "tokenized_content": [2, 8904, 3902, 3, 9643, 1952, 1930, 3655, 2311, 1958, 3790, 2132, 1956, 4010, 8904, 3902, 18, 8563, 16, 2338, 18529, 2132, 2162, 2252, 11726, 1922, 1920, 1962, 3]}, "items": [{"id": "p_1891", "content": "Autoimmune Diseases [SEP] Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are ", "score": 1, "type": null, "tokenized_content": [2, 8904, 3902, 3, 4414, 1988, 2032, 4378, 2007, 1920, 3372, 1927, 3788, 1988, 9793, 1956, 4423, 3878, 2014, 3743, 7917, 2094, 1988, 2032, 3]}]}
{"query": {"id": "q_1892", "content": "infections [SEP] ated to either the stage of the disease at transplant or due to infections. The number of deaths related to cardiac toxicity is low. Howev", "tokenized_content": [2, 5024, 3, 30280, 1007, 1942, 3108, 1920, 3587, 1927, 1920, 2573, 2019, 5192, 2014, 2810, 1942, 5024, 18, 1920, 2529, 1927, 7601, 2712, 1942, 4435, 5532, 1977, 2330, 18, 2307, 3]}, "items": [{"id": "p_1892", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_1893", "content": "cardiac toxicity [SEP] ransplant or due to infections. The number of deaths related to cardiac toxicity is low. However, caution is required when cyclophosphamide or a", "tokenized_content": [2, 4435, 5532, 3, 2845, 3508, 17576, 1031, 2014, 2810, 1942, 5024, 18, 1920, 2529, 1927, 7601, 2712, 1942, 4435, 5532, 1977, 2330, 18, 2406, 16, 12838, 1977, 3414, 2469, 17135, 3]}, "items": [{"id": "p_1893", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_1894", "content": "cyclophosphamide [SEP] d to cardiac toxicity is low. However, caution is required when cyclophosphamide or anthracyclines such as mitoxantrone are used in patients wit", "tokenized_content": [2, 17135, 3, 46, 1942, 4435, 5532, 1977, 2330, 18, 2406, 16, 12838, 1977, 3414, 2469, 17135, 2014, 30021, 1036, 2427, 1966, 25959, 11414, 4905, 2830, 1021, 2032, 2251, 1922, 2132, 3]}, "items": [{"id": "p_1894", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_1895", "content": "anthracyclines [SEP] y is low. However, caution is required when cyclophosphamide or anthracyclines such as mitoxantrone are used in patients with a possible under", "tokenized_content": [2, 30021, 1036, 3, 67, 1977, 2330, 18, 2406, 16, 12838, 1977, 3414, 2469, 17135, 2014, 30021, 1036, 2427, 1966, 25959, 11414, 4905, 2830, 1021, 2032, 2251, 1922, 2132, 1956, 43, 3]}, "items": [{"id": "p_1895", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_1896", "content": "mitoxantrone [SEP] ion is required when cyclophosphamide or anthracyclines such as mitoxantrone are used in patients with a possible underlying heart damage, f", "tokenized_content": [2, 25959, 11414, 4905, 2830, 1021, 3, 4755, 1977, 3414, 2469, 17135, 2014, 30021, 1036, 2427, 1966, 25959, 11414, 4905, 2830, 1021, 2032, 2251, 1922, 2132, 1956, 43, 3216, 5030, 4003, 3]}, "items": [{"id": "p_1896", "content": "Mitoxantrone [SEP] An anthracenedione-derived antineoplastic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25959, 11414, 4905, 2830, 1021, 3, 1925, 19657, 20670, 2290, 17, 3595, 29128, 9969, 5899, 18, 3]}]}
{"query": {"id": "q_1897", "content": "heart damage [SEP] as mitoxantrone are used in patients with a possible underlying heart damage, for example, systemic sclerosis patients. In November 2002, a ", "tokenized_content": [2, 4003, 4293, 3, 1966, 25959, 11414, 4905, 2830, 1021, 2032, 2251, 1922, 2132, 1956, 43, 3216, 5030, 4003, 4293, 16, 1958, 3534, 16, 5510, 11484, 2132, 18, 1922, 12832, 4631, 3]}, "items": [{"id": "p_1897", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_1898", "content": "systemic sclerosis [SEP]  patients with a possible underlying heart damage, for example, systemic sclerosis patients. In November 2002, a meeting was held in Florence, bri", "tokenized_content": [2, 5510, 11484, 3, 2132, 1956, 43, 3216, 5030, 4003, 4293, 16, 1958, 3534, 16, 5510, 11484, 2132, 18, 1922, 12832, 4631, 16, 43, 8957, 1982, 9865, 1922, 14800, 2055, 16, 3]}, "items": [{"id": "p_1898", "content": "Scleroderma, Systemic [SEP] A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GA", "score": 1, "type": null, "tokenized_content": [2, 8266, 20532, 16, 5510, 3, 43, 3724, 2779, 17, 2433, 4770, 1927, 14948, 2960, 18, 2176, 1977, 4378, 2007, 11484, 1922, 1920, 4407, 16, 1920, 9193, 16, 1920, 4003, 16, 1920, 4357, 3]}]}
{"query": {"id": "q_1899", "content": "autoimmune disease [SEP] sible and effective treatment for selected patients with severe autoimmune diseases. Worldwide, over 650 patients have been transplanted in the co", "tokenized_content": [2, 8904, 2573, 3, 9643, 1952, 1930, 3655, 2311, 1958, 3790, 2132, 1956, 4010, 8904, 3902, 18, 8563, 16, 2338, 18529, 2132, 2162, 2252, 11726, 1922, 1920, 2081, 3]}, "items": [{"id": "p_1899", "content": "Autoimmune Diseases [SEP] Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are ", "score": 1, "type": null, "tokenized_content": [2, 8904, 3902, 3, 4414, 1988, 2032, 4378, 2007, 1920, 3372, 1927, 3788, 1988, 9793, 1956, 4423, 3878, 2014, 3743, 7917, 2094, 1988, 2032, 3]}]}
{"query": {"id": "q_1900", "content": "nitric oxide [SEP] Immunohistochemical study on inducible type of nitric oxide (iNOS), basic fibroblast growth factor (bFGF) and tumor growth ", "tokenized_content": [2, 10233, 7491, 3, 9885, 2161, 1990, 9376, 2601, 1927, 10233, 7491, 12, 10320, 13, 16, 5937, 10541, 2905, 2991, 12, 19441, 13, 1930, 2798, 2905, 3]}, "items": [{"id": "p_1900", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_1901", "content": "tumor [SEP]  nitric oxide (iNOS), basic fibroblast growth factor (bFGF) and tumor growth factor-beta1 (TGF-beta1) in arteritis induced in rats by", "tokenized_content": [2, 2798, 3, 10233, 7491, 12, 10320, 13, 16, 5937, 10541, 2905, 2991, 12, 19441, 13, 1930, 2798, 2905, 2991, 17, 24186, 12, 5525, 17, 24186, 13, 1922, 12480, 3600, 2719, 3]}, "items": [{"id": "p_1901", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1902", "content": "arteritis [SEP] owth factor (bFGF) and tumor growth factor-beta1 (TGF-beta1) in arteritis induced in rats by fenoldopam and theophylline, vasodilators.", "tokenized_content": [2, 12480, 3600, 3, 5073, 1963, 2991, 12, 19441, 13, 1930, 2798, 2905, 2991, 17, 24186, 12, 5525, 17, 24186, 13, 1922, 12480, 3600, 2719, 1922, 3615, 2007, 15096, 2643, 8228, 3]}, "items": [{"id": "p_1902", "content": "Arteritis [SEP] INFLAMMATION of any ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12480, 3600, 3, 4531, 1927, 2967, 9345, 18, 3]}]}
{"query": {"id": "q_1903", "content": "fenoldopam [SEP] growth factor-beta1 (TGF-beta1) in arteritis induced in rats by fenoldopam and theophylline, vasodilators.", "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 2905, 2991, 17, 24186, 12, 5525, 17, 24186, 13, 1922, 12480, 3600, 2719, 1922, 3615, 2007, 15096, 2643, 8228, 1035, 1930, 29629, 16, 28194, 1036, 3]}, "items": [{"id": "p_1903", "content": "Fenoldopam [SEP] A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilati", "score": 1, "type": null, "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 43, 7964, 8524, 3148, 7829, 1988, 1977, 2251, 1966, 1925, 16439, 5899, 18, 2176, 25617, 2877, 3772, 2596, 12480, 4362, 13662, 1968, 3]}]}
{"query": {"id": "q_1904", "content": "theophylline [SEP] eta1 (TGF-beta1) in arteritis induced in rats by fenoldopam and theophylline, vasodilators.", "tokenized_content": [2, 29629, 3, 20634, 1009, 12, 5525, 17, 24186, 13, 1922, 12480, 3600, 2719, 1922, 3615, 2007, 15096, 2643, 8228, 1035, 1930, 29629, 16, 28194, 1036, 18, 3]}, "items": [{"id": "p_1904", "content": "Theophylline [SEP] A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous sys", "score": 1, "type": null, "tokenized_content": [2, 29629, 3, 43, 4963, 26059, 10533, 2037, 12459, 1956, 26829, 16, 6689, 3760, 7327, 2031, 16, 14700, 16470, 16, 4435, 1930, 4101, 7580, 7930, 1036, 3]}]}
{"query": {"id": "q_1905", "content": "Arteritis [SEP] Arteritis induced in rats by vasodilators, fenoldopam and theophylline, w", "tokenized_content": [2, 12480, 3600, 3, 12480, 3600, 2719, 1922, 3615, 2007, 28194, 1036, 16, 15096, 2643, 8228, 1035, 1930, 29629, 16, 65, 3]}, "items": [{"id": "p_1905", "content": "Arteritis [SEP] INFLAMMATION of any ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12480, 3600, 3, 4531, 1927, 2967, 9345, 18, 3]}]}
{"query": {"id": "q_1906", "content": "fenoldopam [SEP] Arteritis induced in rats by vasodilators, fenoldopam and theophylline, was examined immunohistochemically for expres", "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 12480, 3600, 2719, 1922, 3615, 2007, 28194, 1036, 16, 15096, 2643, 8228, 1035, 1930, 29629, 16, 1982, 3572, 29820, 1958, 2887, 2808, 3]}, "items": [{"id": "p_1906", "content": "Fenoldopam [SEP] A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilati", "score": 1, "type": null, "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 43, 7964, 8524, 3148, 7829, 1988, 1977, 2251, 1966, 1925, 16439, 5899, 18, 2176, 25617, 2877, 3772, 2596, 12480, 4362, 13662, 1968, 3]}]}
{"query": {"id": "q_1907", "content": "theophylline [SEP] Arteritis induced in rats by vasodilators, fenoldopam and theophylline, was examined immunohistochemically for expressions of inducibl", "tokenized_content": [2, 29629, 3, 12480, 3600, 2719, 1922, 3615, 2007, 28194, 1036, 16, 15096, 2643, 8228, 1035, 1930, 29629, 16, 1982, 3572, 29820, 1958, 9678, 1927, 4320, 2023, 1024, 3]}, "items": [{"id": "p_1907", "content": "Theophylline [SEP] A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous sys", "score": 1, "type": null, "tokenized_content": [2, 29629, 3, 43, 4963, 26059, 10533, 2037, 12459, 1956, 26829, 16, 6689, 3760, 7327, 2031, 16, 14700, 16470, 16, 4435, 1930, 4101, 7580, 7930, 1036, 3]}]}
{"query": {"id": "q_1908", "content": "nitric oxide [SEP] ined immunohistochemically for expressions of inducible type of nitric oxide synthase (iNOS), basic fibroblast growth factor (bFGF) and tumo", "tokenized_content": [2, 10233, 7491, 3, 11116, 1007, 29820, 1958, 9678, 1927, 9376, 2601, 1927, 10233, 7491, 8921, 12, 10320, 13, 16, 5937, 10541, 2905, 2991, 12, 19441, 13, 1930, 2497, 1037, 3]}, "items": [{"id": "p_1908", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_1909", "content": "tumor [SEP] xide synthase (iNOS), basic fibroblast growth factor (bFGF) and tumor growth factor-beta1 (TGF-beta1). Rats were administered fenoldo", "tokenized_content": [2, 2798, 3, 11551, 3695, 8921, 12, 10320, 13, 16, 5937, 10541, 2905, 2991, 12, 19441, 13, 1930, 2798, 2905, 2991, 17, 24186, 12, 5525, 17, 24186, 13, 18, 3615, 1985, 3]}, "items": [{"id": "p_1909", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1910", "content": "arteritis [SEP] F may have a suppressive effect on iNOS expression in these rat arteritis models. On the other hand, TGF-beta1 was not considered to have", "tokenized_content": [2, 12480, 3600, 3, 48, 2278, 2162, 43, 14105, 2495, 1990, 10320, 2294, 1922, 2144, 3067, 12480, 3600, 3130, 18, 1990, 1920, 2303, 3897, 16, 5525, 17, 24186, 1982, 2084, 3311, 3]}, "items": [{"id": "p_1910", "content": "Arteritis [SEP] INFLAMMATION of any ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12480, 3600, 3, 4531, 1927, 2967, 9345, 18, 3]}]}
{"query": {"id": "q_1911", "content": "Low-molecular-weight heparin [SEP] Low-molecular-weight heparin for the treatment of patients with mechanical heart valves.", "tokenized_content": [2, 2330, 17, 3272, 17, 3388, 9962, 3, 2330, 17, 3272, 17, 3388, 9962, 1958, 1920, 2311, 1927, 2132, 1956, 5821, 4003, 19335, 18, 3]}, "items": [{"id": "p_1911", "content": "Heparin, Low-Molecular-Weight [SEP] Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective a", "score": 1, "type": null, "tokenized_content": [2, 9962, 16, 2330, 17, 3272, 17, 3388, 3, 9962, 6872, 1956, 43, 3272, 3388, 5394, 2192, 16055, 1930, 22348, 7546, 18, 2144, 2330, 17, 3272, 17, 3388, 6872, 2032, 3655, 43, 3]}]}
{"query": {"id": "q_1912", "content": "Unfractionated heparin [SEP]  noncardiac surgery, non-surgical interventions, and pregnancy. Unfractionated heparin (UH) is currently the substitute for selected patients. Low-mol", "tokenized_content": [2, 6281, 27320, 1981, 9962, 3, 9341, 25111, 3782, 16, 2447, 17, 4548, 4984, 16, 1930, 5284, 18, 6281, 27320, 1981, 9962, 12, 23476, 13, 1977, 5077, 1920, 18336, 1958, 3790, 3]}, "items": [{"id": "p_1912", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_1913", "content": "UH [SEP] -surgical interventions, and pregnancy. Unfractionated heparin (UH) is currently the substitute for selected patients. Low-molecul", "tokenized_content": [2, 23476, 3, 17, 4548, 4984, 16, 1930, 5284, 18, 6281, 27320, 1981, 9962, 12, 23476, 13, 1977, 5077, 1920, 18336, 1958, 3790, 2132, 18, 2330, 17, 2747, 1944, 3]}, "items": [{"id": "p_1913", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_1914", "content": "Low-molecular-weight heparin [SEP] heparin (UH) is currently the substitute for selected patients. Low-molecular-weight heparin (LMWH) offers theoretical advantages over UH, but is not curren", "tokenized_content": [2, 2330, 17, 3272, 17, 3388, 9962, 3, 9962, 12, 23476, 13, 1977, 5077, 1920, 18336, 1958, 3790, 2132, 18, 2330, 17, 3272, 17, 3388, 9962, 12, 28722, 1023, 13, 9874, 3]}, "items": [{"id": "p_1914", "content": "Heparin, Low-Molecular-Weight [SEP] Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective a", "score": 1, "type": null, "tokenized_content": [2, 9962, 16, 2330, 17, 3272, 17, 3388, 3, 9962, 6872, 1956, 43, 3272, 3388, 5394, 2192, 16055, 1930, 22348, 7546, 18, 2144, 2330, 17, 3272, 17, 3388, 6872, 2032, 3655, 43, 3]}]}
{"query": {"id": "q_1915", "content": "LMWH [SEP] substitute for selected patients. Low-molecular-weight heparin (LMWH) offers theoretical advantages over UH, but is not currently co", "tokenized_content": [2, 28722, 1023, 3, 18336, 1958, 3790, 2132, 18, 2330, 17, 3272, 17, 3388, 9962, 12, 28722, 1023, 13, 9874, 7768, 8518, 2338, 23476, 16, 2308, 1977, 2084, 5077, 2081, 3]}, "items": [{"id": "p_1915", "content": "Heparin, Low-Molecular-Weight [SEP] Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective a", "score": 1, "type": null, "tokenized_content": [2, 9962, 16, 2330, 17, 3272, 17, 3388, 3, 9962, 6872, 1956, 43, 3272, 3388, 5394, 2192, 16055, 1930, 22348, 7546, 18, 2144, 2330, 17, 3272, 17, 3388, 6872, 2032, 3655, 43, 3]}]}
{"query": {"id": "q_1916", "content": "thromboembolic [SEP] randomized, and only one was prospective. Data to establish the thromboembolic risk were incomplete. After excluding case reports, the followi", "tokenized_content": [2, 25580, 3, 5542, 16, 1930, 2444, 2340, 1982, 6315, 18, 2230, 1942, 5389, 1920, 25580, 2565, 1985, 9876, 18, 2256, 10566, 3087, 4710, 16, 1920, 2396, 1033, 3]}, "items": [{"id": "p_1916", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1917", "content": "thromboembolism [SEP] 6); (d) long-term, in pregnancy (n = 10). The incidence rate of thromboembolism was 0.9% for all the studies and 0.5, 0, 20, and 0% in groups a", "tokenized_content": [2, 23821, 3, 26, 13, 31, 12, 46, 13, 2815, 17, 2576, 16, 1922, 5284, 12, 56, 33, 2119, 13, 18, 1920, 4332, 2769, 1927, 23821, 1982, 20, 18, 29, 9, 3]}, "items": [{"id": "p_1917", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1918", "content": "hemorrhage [SEP]  0.5, 0, 20, and 0% in groups a, b, c, and d, respectively; for hemorrhage, the overall rate was 3.4% (3.8, 2.6, 10, and 0% for the respec", "tokenized_content": [2, 10489, 3, 20, 18, 25, 16, 20, 16, 2036, 16, 1930, 20, 9, 1922, 2671, 43, 16, 44, 16, 45, 16, 1930, 46, 16, 2763, 31, 1958, 10489, 16, 1920, 3]}, "items": [{"id": "p_1918", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1919", "content": "Topiramate [SEP] Topiramate-induced nephrolithiasis.", "tokenized_content": [2, 3700, 11979, 23874, 3, 3700, 11979, 23874, 17, 2719, 7737, 2226, 29016, 18, 3]}, "items": [{"id": "p_1919", "content": "topiramate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3700, 11979, 23874, 3, 3]}]}
{"query": {"id": "q_1920", "content": "nephrolithiasis [SEP] Topiramate-induced nephrolithiasis.", "tokenized_content": [2, 7737, 2226, 29016, 3, 3700, 11979, 23874, 17, 2719, 7737, 2226, 29016, 18, 3]}, "items": [{"id": "p_1920", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_1921", "content": "Topiramate [SEP] Topiramate is a recently developed antiepileptic medication that is becomi", "tokenized_content": [2, 3700, 11979, 23874, 3, 3700, 11979, 23874, 1977, 43, 3998, 3530, 29132, 6093, 1988, 1977, 2605, 1947, 1033, 3]}, "items": [{"id": "p_1921", "content": "topiramate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3700, 11979, 23874, 3, 3]}]}
{"query": {"id": "q_1922", "content": "refractory seizures [SEP] ming more widely prescribed because of its efficacy in treating refractory seizures. Urologists should be aware that this medication can cause meta", "tokenized_content": [2, 10923, 10060, 3, 2360, 1029, 2253, 5673, 9975, 2882, 1927, 2496, 4348, 1922, 8247, 10923, 10060, 18, 17684, 3535, 3066, 1998, 11207, 1988, 2052, 6093, 2112, 3936, 5880, 3]}, "items": [{"id": "p_1922", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_1923", "content": "metabolic acidosis [SEP] ures. Urologists should be aware that this medication can cause metabolic acidosis in patients secondary to inhibition of carbonic anhydrase. In a", "tokenized_content": [2, 4487, 19051, 3, 6794, 1036, 18, 17684, 3535, 3066, 1998, 11207, 1988, 2052, 6093, 2112, 3936, 4487, 19051, 1922, 2132, 4067, 1942, 3523, 1927, 5056, 1935, 22018, 2051, 18, 1922, 3]}, "items": [{"id": "p_1923", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_1924", "content": "calcium phosphate [SEP]  drop in urine pH. These factors can lead to the development of calcium phosphate nephrolithiasis. We report the first two cases of topiramate-in", "tokenized_content": [2, 5016, 5413, 3, 7086, 1922, 6960, 2087, 18, 2144, 2790, 2112, 2949, 1942, 1920, 2740, 1927, 5016, 5413, 7737, 2226, 29016, 18, 2038, 3809, 1920, 2561, 2288, 2919, 1927, 3700, 3]}, "items": [{"id": "p_1924", "content": "calcium phosphate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5016, 5413, 3, 3]}]}
{"query": {"id": "q_1925", "content": "nephrolithiasis [SEP]  These factors can lead to the development of calcium phosphate nephrolithiasis. We report the first two cases of topiramate-induced nephrolith", "tokenized_content": [2, 7737, 2226, 29016, 3, 2144, 2790, 2112, 2949, 1942, 1920, 2740, 1927, 5016, 5413, 7737, 2226, 29016, 18, 2038, 3809, 1920, 2561, 2288, 2919, 1927, 3700, 11979, 23874, 17, 2719, 3]}, "items": [{"id": "p_1925", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_1926", "content": "topiramate [SEP] ium phosphate nephrolithiasis. We report the first two cases of topiramate-induced nephrolithiasis in the urologic literature.", "tokenized_content": [2, 3700, 11979, 23874, 3, 11176, 1035, 5413, 7737, 2226, 29016, 18, 2038, 3809, 1920, 2561, 2288, 2919, 1927, 3700, 11979, 23874, 17, 2719, 7737, 2226, 29016, 1922, 1920, 17684, 1935, 3]}, "items": [{"id": "p_1926", "content": "topiramate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3700, 11979, 23874, 3, 3]}]}
{"query": {"id": "q_1927", "content": "Spironolactone [SEP] Spironolactone: is it a novel drug for the prevention of amphotericin B-relate", "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 22075, 11873, 5148, 2341, 2290, 30, 1977, 2176, 43, 4008, 2838, 1958, 1920, 5455, 1927, 23210, 44, 17, 12448, 3]}, "items": [{"id": "p_1927", "content": "Spironolactone [SEP] A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatm", "score": 1, "type": null, "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 43, 9057, 17981, 26829, 1988, 8016, 2007, 18394, 1927, 16944, 1922, 1920, 6583, 4604, 14876, 18, 2176, 1977, 2251, 4994, 1922, 1920, 2297, 1035, 3]}]}
{"query": {"id": "q_1928", "content": "amphotericin B [SEP] Spironolactone: is it a novel drug for the prevention of amphotericin B-related hypokalemia in cancer patients?", "tokenized_content": [2, 23210, 44, 3, 22075, 11873, 5148, 2341, 2290, 30, 1977, 2176, 43, 4008, 2838, 1958, 1920, 5455, 1927, 23210, 44, 17, 2712, 14395, 7640, 1952, 6026, 1922, 2539, 2132, 35, 3]}, "items": [{"id": "p_1928", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1929", "content": "hypokalemia [SEP] is it a novel drug for the prevention of amphotericin B-related hypokalemia in cancer patients?", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 1977, 2176, 43, 4008, 2838, 1958, 1920, 5455, 1927, 23210, 44, 17, 2712, 14395, 7640, 1952, 6026, 1922, 2539, 2132, 35, 3]}, "items": [{"id": "p_1929", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1930", "content": "cancer [SEP] rug for the prevention of amphotericin B-related hypokalemia in cancer patients?", "tokenized_content": [2, 2539, 3, 23148, 1958, 1920, 5455, 1927, 23210, 44, 17, 2712, 14395, 7640, 1952, 6026, 1922, 2539, 2132, 35, 3]}, "items": [{"id": "p_1930", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1931", "content": "Nephrotoxicity [SEP] OBJECTIVE: Nephrotoxicity is the major adverse effect of amphotericin B (AmB), often limi", "tokenized_content": [2, 27880, 3, 4470, 30, 27880, 1977, 1920, 3044, 5246, 2495, 1927, 23210, 44, 12, 6168, 13, 16, 3868, 2784, 1033, 3]}, "items": [{"id": "p_1931", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1932", "content": "amphotericin B [SEP] OBJECTIVE: Nephrotoxicity is the major adverse effect of amphotericin B (AmB), often limiting administration of full dosage. Selective ", "tokenized_content": [2, 23210, 44, 3, 4470, 30, 27880, 1977, 1920, 3044, 5246, 2495, 1927, 23210, 44, 12, 6168, 13, 16, 3868, 8051, 4183, 1927, 4125, 9998, 18, 5328, 3]}, "items": [{"id": "p_1932", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1933", "content": "AmB [SEP] : Nephrotoxicity is the major adverse effect of amphotericin B (AmB), often limiting administration of full dosage. Selective dista", "tokenized_content": [2, 6168, 3, 30, 27880, 1977, 1920, 3044, 5246, 2495, 1927, 23210, 44, 12, 6168, 13, 16, 3868, 8051, 4183, 1927, 4125, 9998, 18, 5328, 3653, 1019, 3]}, "items": [{"id": "p_1933", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1934", "content": "toxicity [SEP] OBJECTIVE: Nephrotoxicity is the major adverse effect of amphotericin B (AmB), often limi", "tokenized_content": [2, 5532, 3, 4470, 30, 27880, 1977, 1920, 3044, 5246, 2495, 1927, 23210, 44, 12, 6168, 13, 16, 3868, 2784, 1033, 3]}, "items": [{"id": "p_1934", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1935", "content": "potassium [SEP] ar epithelial toxicity seems to be responsible for the profound potassium wasting that is a major clinical side effect of treatment with ", "tokenized_content": [2, 9057, 3, 2245, 4944, 5532, 6123, 1942, 1998, 5061, 1958, 1920, 11098, 9057, 23217, 1988, 1977, 43, 3044, 2535, 4159, 2495, 1927, 2311, 1956, 3]}, "items": [{"id": "p_1935", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1936", "content": "Potassium [SEP] ing that is a major clinical side effect of treatment with AmB. Potassium depletion also potentiates the tubular toxicity of AmB. This st", "tokenized_content": [2, 9057, 3, 30393, 1988, 1977, 43, 3044, 2535, 4159, 2495, 1927, 2311, 1956, 6168, 18, 9057, 6882, 2222, 29734, 1920, 11755, 5532, 1927, 6168, 18, 2052, 1955, 3]}, "items": [{"id": "p_1936", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1937", "content": "spironolactone [SEP] xicity of AmB. This study was designed to assess the ability of spironolactone to reduce potassium requirements and to prevent hypokalemia in ", "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 11551, 3349, 3145, 1927, 6168, 18, 2052, 2161, 1982, 4609, 1942, 2634, 1920, 3682, 1927, 22075, 11873, 5148, 2341, 2290, 1942, 4412, 9057, 8456, 3]}, "items": [{"id": "p_1937", "content": "Spironolactone [SEP] A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatm", "score": 1, "type": null, "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 43, 9057, 17981, 26829, 1988, 8016, 2007, 18394, 1927, 16944, 1922, 1920, 6583, 4604, 14876, 18, 2176, 1977, 2251, 4994, 1922, 1920, 2297, 1035, 3]}]}
{"query": {"id": "q_1938", "content": "hypokalemia [SEP]  spironolactone to reduce potassium requirements and to prevent hypokalemia in neutropenic patients on AmB treatment. METHODS: In this stud", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 22075, 11873, 5148, 2341, 2290, 1942, 4412, 9057, 8456, 1930, 1942, 4625, 14395, 7640, 1952, 6026, 1922, 16286, 7245, 2132, 1990, 6168, 2311, 18, 2860, 3]}, "items": [{"id": "p_1938", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_1939", "content": "neutropenic [SEP]  to reduce potassium requirements and to prevent hypokalemia in neutropenic patients on AmB treatment. METHODS: In this study 26 patients w", "tokenized_content": [2, 16286, 7245, 3, 1942, 4412, 9057, 8456, 1930, 1942, 4625, 14395, 7640, 1952, 6026, 1922, 16286, 7245, 2132, 1990, 6168, 2311, 18, 2860, 30, 1922, 2052, 2161, 3179, 2132, 65, 3]}, "items": [{"id": "p_1939", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1940", "content": "hematological disorders [SEP]  AmB treatment. METHODS: In this study 26 patients with various hematological disorders were randomized to receive either intravenous AmB alone or AmB ", "tokenized_content": [2, 17339, 4414, 3, 6168, 2311, 18, 2860, 30, 1922, 2052, 2161, 3179, 2132, 1956, 3425, 17339, 4414, 1985, 5542, 1942, 7130, 3108, 7307, 6168, 4298, 2014, 6168, 3]}, "items": [{"id": "p_1940", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_1941", "content": "fungal infection [SEP] actone 100 mg twice daily when developing a proven or suspected fungal infection. RESULTS: Patients receiving concomitant AmB and spironolactone", "tokenized_content": [2, 8697, 2909, 3, 4033, 2290, 2813, 2786, 6470, 4692, 2469, 5130, 43, 9253, 2014, 9407, 8697, 2909, 18, 2274, 30, 2132, 5962, 8537, 6168, 1930, 22075, 11873, 5148, 2341, 2290, 3]}, "items": [{"id": "p_1941", "content": "Mycoses [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5078, 12278, 3, 3]}]}
{"query": {"id": "q_1942", "content": "Dopamine [SEP] Dopamine D2 receptor signaling controls neuronal cell death induced by m", "tokenized_content": [2, 7964, 3, 7964, 8631, 3148, 3197, 3562, 5121, 2024, 3539, 2719, 2007, 55, 3]}, "items": [{"id": "p_1942", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1943", "content": "Dopamine [SEP] Dopamine (DA), through D1/D2 receptor-mediated signaling, plays a major ", "tokenized_content": [2, 7964, 3, 7964, 12, 3692, 13, 16, 2596, 8524, 19, 8631, 3148, 17, 3434, 3197, 16, 5705, 43, 3044, 3]}, "items": [{"id": "p_1943", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1944", "content": "DA [SEP] Dopamine (DA), through D1/D2 receptor-mediated signaling, plays a major role", "tokenized_content": [2, 3692, 3, 7964, 12, 3692, 13, 16, 2596, 8524, 19, 8631, 3148, 17, 3434, 3197, 16, 5705, 43, 3044, 2770, 3]}, "items": [{"id": "p_1944", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1945", "content": "epileptic seizures [SEP] ceptor-mediated signaling, plays a major role in the control of epileptic seizures arising in the limbic system. Excitotoxicity leading to neurona", "tokenized_content": [2, 16304, 10060, 3, 17008, 2684, 17, 3434, 3197, 16, 5705, 43, 3044, 2770, 1922, 1920, 2285, 1927, 16304, 10060, 11894, 1922, 1920, 20590, 2433, 18, 29239, 4523, 1942, 7428, 1019, 3]}, "items": [{"id": "p_1945", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_1946", "content": "seizures [SEP] iated signaling, plays a major role in the control of epileptic seizures arising in the limbic system. Excitotoxicity leading to neurona", "tokenized_content": [2, 10060, 3, 21006, 1919, 3197, 16, 5705, 43, 3044, 2770, 1922, 1920, 2285, 1927, 16304, 10060, 11894, 1922, 1920, 20590, 2433, 18, 29239, 4523, 1942, 7428, 1019, 3]}, "items": [{"id": "p_1946", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1947", "content": "epilepsy [SEP] le is known about the role of DA receptors in the occurrence of epilepsy-induced neuronal cell death. Here we analyze the occurrence of ", "tokenized_content": [2, 9741, 3, 2071, 1977, 3171, 3001, 1920, 2770, 1927, 3692, 4086, 1922, 1920, 6564, 1927, 9741, 17, 2719, 5121, 2024, 3539, 18, 3410, 2038, 7125, 1920, 6564, 1927, 3]}, "items": [{"id": "p_1947", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_1948", "content": "neurotoxicity [SEP] onal cell death. Here we analyze the occurrence of seizures and neurotoxicity in D2R -/- mice treated with the cholinergic agonist pilocarpin", "tokenized_content": [2, 18034, 3, 1990, 1923, 2024, 3539, 18, 3410, 2038, 7125, 1920, 6564, 1927, 10060, 1930, 18034, 1922, 30290, 17, 19, 17, 2518, 2868, 1956, 1920, 13908, 7829, 7547, 7095, 9512, 3]}, "items": [{"id": "p_1948", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_1949", "content": "pilocarpine [SEP] rotoxicity in D2R -/- mice treated with the cholinergic agonist pilocarpine. We compared these results with those previously obtained with ", "tokenized_content": [2, 7547, 7095, 12184, 3, 5337, 14916, 1922, 30290, 17, 19, 17, 2518, 2868, 1956, 1920, 13908, 7829, 7547, 7095, 12184, 18, 2038, 2452, 2144, 2274, 1956, 2690, 3024, 2926, 1956, 3]}, "items": [{"id": "p_1949", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_1950", "content": "kainic acid [SEP] . We compared these results with those previously obtained with kainic acid (KA), a potent glutamate agonist. Importantly, D2R -/- mice dev", "tokenized_content": [2, 24714, 1935, 2687, 3, 18, 2038, 2452, 2144, 2274, 1956, 2690, 3024, 2926, 1956, 24714, 1935, 2687, 12, 9580, 13, 16, 43, 6828, 7627, 7829, 18, 6444, 16, 30290, 17, 3]}, "items": [{"id": "p_1950", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_1951", "content": "KA [SEP]  these results with those previously obtained with kainic acid (KA), a potent glutamate agonist. Importantly, D2R -/- mice develop", "tokenized_content": [2, 9580, 3, 2144, 2274, 1956, 2690, 3024, 2926, 1956, 24714, 1935, 2687, 12, 9580, 13, 16, 43, 6828, 7627, 7829, 18, 6444, 16, 30290, 17, 19, 17, 2518, 2392, 3]}, "items": [{"id": "p_1951", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_1952", "content": "glutamate [SEP]  with those previously obtained with kainic acid (KA), a potent glutamate agonist. Importantly, D2R -/- mice develop seizures at doses of", "tokenized_content": [2, 7627, 3, 1956, 2690, 3024, 2926, 1956, 24714, 1935, 2687, 12, 9580, 13, 16, 43, 6828, 7627, 7829, 18, 6444, 16, 30290, 17, 19, 17, 2518, 2392, 10060, 2019, 5312, 3]}, "items": [{"id": "p_1952", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_1953", "content": "acetylcholine [SEP] lowers the threshold for seizures induced by both glutamate and acetylcholine. Moreover, the dopaminergic control of epilepsy-induced neurode", "tokenized_content": [2, 14561, 3, 25617, 1920, 4683, 1958, 10060, 2719, 2007, 2321, 7627, 1930, 14561, 18, 3950, 16, 1920, 12214, 2285, 1927, 9741, 17, 2719, 7927, 3]}, "items": [{"id": "p_1953", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1954", "content": "neurodegeneration [SEP] choline. Moreover, the dopaminergic control of epilepsy-induced neurodegeneration seems to be mediated by distinct interactions of D2R signaling ", "tokenized_content": [2, 14481, 3, 15440, 18, 3950, 16, 1920, 12214, 2285, 1927, 9741, 17, 2719, 14481, 6123, 1942, 1998, 3434, 2007, 4493, 3719, 1927, 30290, 3197, 3]}, "items": [{"id": "p_1954", "content": "Neurodegenerative Diseases [SEP] Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often ", "score": 1, "type": null, "tokenized_content": [2, 11128, 3902, 3, 16321, 1930, 13088, 2961, 2154, 2032, 4378, 2007, 7529, 7580, 2433, 5273, 18, 2144, 4414, 2032, 3868, 3]}]}
{"query": {"id": "q_1955", "content": "risperidone [SEP] Treatment of risperidone-induced hyperprolactinemia with a dopamine agonist in children.", "tokenized_content": [2, 26991, 3, 2311, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1956, 43, 7964, 7829, 1922, 3069, 18, 3]}, "items": [{"id": "p_1955", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_1956", "content": "hyperprolactinemia [SEP] Treatment of risperidone-induced hyperprolactinemia with a dopamine agonist in children.", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2311, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1956, 43, 7964, 7829, 1922, 3069, 18, 3]}, "items": [{"id": "p_1956", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_1957", "content": "dopamine [SEP] Treatment of risperidone-induced hyperprolactinemia with a dopamine agonist in children.", "tokenized_content": [2, 7964, 3, 2311, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1956, 43, 7964, 7829, 1922, 3069, 18, 3]}, "items": [{"id": "p_1957", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1958", "content": "Risperidone [SEP] BACKGROUND: Risperidone, a potent antagonist of both serotonergic (5HT2A) and dopaminer", "tokenized_content": [2, 26991, 3, 3872, 30, 26991, 16, 43, 6828, 8151, 1927, 2321, 21292, 12, 29621, 5896, 13, 1930, 7964, 1005, 3]}, "items": [{"id": "p_1958", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_1959", "content": "hyperprolactinemia [SEP] nergic (5HT2A) and dopaminergic D2 receptors is associated with hyperprolactinemia in adults and children. Chronically elevated prolactin levels i", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 4919, 11545, 12, 29621, 5896, 13, 1930, 12214, 8631, 4086, 1977, 2458, 1956, 4194, 15743, 11686, 3847, 1922, 4440, 1930, 3069, 18, 16132, 4664, 18386, 3]}, "items": [{"id": "p_1959", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_1960", "content": "prolactinomas [SEP] hildren. Chronically elevated prolactin levels in children with prolactinomas may be associated with arrested growth and development resultin", "tokenized_content": [2, 18386, 4956, 3, 18077, 3883, 1917, 18, 16132, 4664, 18386, 2428, 1922, 3069, 1956, 18386, 4956, 2278, 1998, 2458, 1956, 17398, 2905, 1930, 2740, 3211, 1921, 3]}, "items": [{"id": "p_1960", "content": "Prolactinoma [SEP] A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTO", "score": 1, "type": null, "tokenized_content": [2, 18386, 2954, 3, 43, 10621, 16530, 2154, 15989, 1036, 18386, 16, 4523, 1942, 4194, 15743, 11686, 3847, 18, 2535, 10952, 3951, 15969, 21588, 31, 9479, 1037, 3]}]}
{"query": {"id": "q_1961", "content": "delayed puberty [SEP] ciated with arrested growth and development resulting in either delayed puberty or short stature. These possibilities stress the importance of ", "tokenized_content": [2, 7083, 18335, 3, 24748, 2013, 1956, 17398, 2905, 1930, 2740, 3864, 1922, 3108, 7083, 18335, 2014, 3662, 25906, 18, 2144, 13860, 3071, 1920, 4737, 1927, 3]}, "items": [{"id": "p_1961", "content": "Puberty, Delayed [SEP] The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the ", "score": 1, "type": null, "tokenized_content": [2, 18335, 16, 7083, 3, 1920, 3630, 1927, 2740, 1927, 5702, 7655, 1922, 10294, 1930, 9201, 2019, 43, 23469, 2632, 1988, 1977, 22, 18, 25, 2970, 9804, 3538, 1920, 3]}]}
{"query": {"id": "q_1962", "content": "risperidone [SEP] erprolactinemia in youth. We report the successful treatment of risperidone-induced hyperprolactinemia with cabergoline in youth. METHODS: ", "tokenized_content": [2, 26991, 3, 15950, 2226, 11686, 3847, 1922, 7925, 18, 2038, 3809, 1920, 4654, 2311, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1956, 11026, 2693, 8419, 1922, 7925, 18, 2860, 3]}, "items": [{"id": "p_1962", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_1963", "content": "cabergoline [SEP] essful treatment of risperidone-induced hyperprolactinemia with cabergoline in youth. METHODS: We undertook a retrospective case review of ", "tokenized_content": [2, 11026, 2693, 8419, 3, 4023, 2903, 2311, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1956, 11026, 2693, 8419, 1922, 7925, 18, 2860, 30, 2038, 23111, 43, 6968, 3087, 3043, 3]}, "items": [{"id": "p_1963", "content": "cabergoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11026, 2693, 8419, 3, 3]}]}
{"query": {"id": "q_1964", "content": "Mental Disorders [SEP] ales (age 6-11 years) with Diagnostic and Statistical Manual of Mental Disorders (fourth edition) bipolar disorder or psychoses, with risperidon", "tokenized_content": [2, 5018, 4414, 3, 19543, 1036, 12, 2632, 26, 17, 2513, 2739, 13, 1956, 4785, 1930, 3850, 8507, 1927, 5018, 4414, 12, 8776, 17407, 13, 10275, 4770, 2014, 9855, 1918, 16, 3]}, "items": [{"id": "p_1964", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1965", "content": "bipolar disorder [SEP] tic and Statistical Manual of Mental Disorders (fourth edition) bipolar disorder or psychoses, with risperidone-induced elevations in serum prol", "tokenized_content": [2, 10275, 4770, 3, 18298, 1930, 3850, 8507, 1927, 5018, 4414, 12, 8776, 17407, 13, 10275, 4770, 2014, 9855, 1918, 16, 1956, 26991, 17, 2719, 17554, 1922, 3256, 3192, 3]}, "items": [{"id": "p_1965", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_1966", "content": "psychoses [SEP] Manual of Mental Disorders (fourth edition) bipolar disorder or psychoses, with risperidone-induced elevations in serum prolactin levels ", "tokenized_content": [2, 9855, 1918, 3, 8507, 1927, 5018, 4414, 12, 8776, 17407, 13, 10275, 4770, 2014, 9855, 1918, 16, 1956, 26991, 17, 2719, 17554, 1922, 3256, 18386, 2428, 3]}, "items": [{"id": "p_1966", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_1967", "content": "Cabergoline [SEP]  duration of therapy with risperidone was 788.5 +/- 162.5 days. Cabergoline was well tolerated without adverse effects. CONCLUSIONS: Caberg", "tokenized_content": [2, 11026, 2693, 8419, 3, 4392, 1927, 3181, 1956, 26991, 1982, 5440, 1025, 18, 25, 15, 19, 17, 15333, 18, 25, 3000, 18, 11026, 2693, 8419, 1982, 2486, 11117, 2979, 5246, 3]}, "items": [{"id": "p_1967", "content": "cabergoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11026, 2693, 8419, 3, 3]}]}
{"query": {"id": "q_1968", "content": "Cholestatic jaundice [SEP] Cholestatic jaundice associated with the use of metformin.", "tokenized_content": [2, 21211, 2479, 25314, 3, 21211, 2479, 25314, 2458, 1956, 1920, 2485, 1927, 11885, 18, 3]}, "items": [{"id": "p_1968", "content": "Jaundice, Obstructive [SEP] Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIA", "score": 1, "type": null, "tokenized_content": [2, 25314, 16, 12234, 3, 25314, 16, 1920, 2625, 1956, 7463, 2471, 4166, 1927, 1920, 4407, 1930, 27103, 5726, 16, 1988, 1977, 2810, 1942, 5761, 9619, 3426, 1922, 1920, 5088, 2126, 3]}]}
{"query": {"id": "q_1969", "content": "metformin [SEP] Cholestatic jaundice associated with the use of metformin.", "tokenized_content": [2, 11885, 3, 21211, 2479, 25314, 2458, 1956, 1920, 2485, 1927, 11885, 18, 3]}, "items": [{"id": "p_1969", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1970", "content": "cholestatic jaundice [SEP] We report a patient who developed cholestatic jaundice shortly after initiation of treatment with metformin hydrochlor", "tokenized_content": [2, 21211, 2479, 25314, 3, 2038, 3809, 43, 2774, 2746, 3530, 21211, 2479, 25314, 17002, 2256, 6035, 1927, 2311, 1956, 11885, 14369, 3]}, "items": [{"id": "p_1970", "content": "Jaundice, Obstructive [SEP] Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIA", "score": 1, "type": null, "tokenized_content": [2, 25314, 16, 12234, 3, 25314, 16, 1920, 2625, 1956, 7463, 2471, 4166, 1927, 1920, 4407, 1930, 27103, 5726, 16, 1988, 1977, 2810, 1942, 5761, 9619, 3426, 1922, 1920, 5088, 2126, 3]}]}
{"query": {"id": "q_1971", "content": "metformin hydrochloride [SEP] cholestatic jaundice shortly after initiation of treatment with metformin hydrochloride. Ultrasound of the liver and abdominal CT were normal. An ERCP ", "tokenized_content": [2, 11885, 16675, 3, 21211, 2479, 25314, 17002, 2256, 6035, 1927, 2311, 1956, 11885, 16675, 18, 7424, 1927, 1920, 3568, 1930, 6900, 3369, 1985, 2791, 18, 1925, 26954, 3]}, "items": [{"id": "p_1971", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1972", "content": "cholestasis [SEP] natomy. A percutaneous liver biopsy was obtained showing marked cholestasis, with portal edema, ductular proliferation, and acute inflammat", "tokenized_content": [2, 30086, 3, 3898, 3542, 18, 43, 12826, 3568, 6831, 1982, 2926, 4570, 4961, 30086, 16, 1956, 10669, 10144, 16, 10840, 2168, 4031, 16, 1930, 3939, 3121, 1926, 3]}, "items": [{"id": "p_1972", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_1973", "content": "edema [SEP] ver biopsy was obtained showing marked cholestasis, with portal edema, ductular proliferation, and acute inflammation. Metformin hydr", "tokenized_content": [2, 10144, 3, 3566, 6831, 1982, 2926, 4570, 4961, 30086, 16, 1956, 10669, 10144, 16, 10840, 2168, 4031, 16, 1930, 3939, 4531, 18, 11885, 9698, 3]}, "items": [{"id": "p_1973", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_1974", "content": "inflammation [SEP] olestasis, with portal edema, ductular proliferation, and acute inflammation. Metformin hydrochloride was discontinued, and the patient's ja", "tokenized_content": [2, 4531, 3, 12188, 2156, 3932, 16, 1956, 10669, 10144, 16, 10840, 2168, 4031, 16, 1930, 3939, 4531, 18, 11885, 16675, 1982, 16087, 16, 1930, 1920, 2774, 11, 61, 13149, 3]}, "items": [{"id": "p_1974", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_1975", "content": "Metformin hydrochloride [SEP] h portal edema, ductular proliferation, and acute inflammation. Metformin hydrochloride was discontinued, and the patient's jaundice resolved slowly ov", "tokenized_content": [2, 11885, 16675, 3, 50, 10669, 10144, 16, 10840, 2168, 4031, 16, 1930, 3939, 4531, 18, 11885, 16675, 1982, 16087, 16, 1930, 1920, 2774, 11, 61, 25314, 8397, 11240, 4285, 3]}, "items": [{"id": "p_1975", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1976", "content": "jaundice [SEP] We report a patient who developed cholestatic jaundice shortly after initiation of treatment with metformin hydrochlor", "tokenized_content": [2, 25314, 3, 2038, 3809, 43, 2774, 2746, 3530, 21211, 2479, 25314, 17002, 2256, 6035, 1927, 2311, 1956, 11885, 14369, 3]}, "items": [{"id": "p_1976", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_1977", "content": "metformin [SEP] cholestatic jaundice shortly after initiation of treatment with metformin hydrochloride. Ultrasound of the liver and abdominal CT were no", "tokenized_content": [2, 11885, 3, 21211, 2479, 25314, 17002, 2256, 6035, 1927, 2311, 1956, 11885, 16675, 18, 7424, 1927, 1920, 3568, 1930, 6900, 3369, 1985, 2239, 3]}, "items": [{"id": "p_1977", "content": "Metformin [SEP] A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi", "score": 1, "type": null, "tokenized_content": [2, 11885, 3, 43, 9769, 13785, 2261, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 1974, 1033, 3]}]}
{"query": {"id": "q_1978", "content": "hepatotoxicity [SEP] ve that this case represents an example of metformin-associated hepatotoxicity, the first such case reported.", "tokenized_content": [2, 24126, 3, 3428, 1988, 2052, 3087, 4972, 1925, 3534, 1927, 11885, 17, 2458, 24126, 16, 1920, 2561, 2427, 3087, 2568, 18, 3]}, "items": [{"id": "p_1978", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1979", "content": "vigabatrin [SEP] potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.", "tokenized_content": [2, 11505, 20013, 17670, 3, 9322, 16, 1930, 21632, 4260, 26313, 3796, 1922, 2132, 1956, 11505, 20013, 17670, 17, 6898, 3737, 3559, 19837, 18, 3]}, "items": [{"id": "p_1979", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_1980", "content": "visual field constriction [SEP] ocal electroretinography in patients with vigabatrin-attributed visual field constriction.", "tokenized_content": [2, 3737, 3559, 19837, 3, 5084, 1923, 4260, 26313, 3796, 1922, 2132, 1956, 11505, 20013, 17670, 17, 6898, 3737, 3559, 19837, 18, 3]}, "items": [{"id": "p_1980", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_1981", "content": "visual field constriction [SEP] PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported. The", "tokenized_content": [2, 3737, 3559, 19837, 3, 5120, 30, 9371, 3737, 3559, 19837, 6212, 1942, 1998, 2458, 1956, 11505, 20013, 17670, 2258, 2252, 2568, 18, 1920, 3]}, "items": [{"id": "p_1981", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_1982", "content": "vigabatrin [SEP] tomatic visual field constriction thought to be associated with vigabatrin has been reported. The current study investigated the visual fi", "tokenized_content": [2, 11505, 20013, 17670, 3, 5970, 2479, 3737, 3559, 19837, 6212, 1942, 1998, 2458, 1956, 11505, 20013, 17670, 2258, 2252, 2568, 18, 1920, 3214, 2161, 3845, 1920, 3737, 14856, 3]}, "items": [{"id": "p_1982", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_1983", "content": "visual field loss [SEP] rophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously. Six of the patients we", "tokenized_content": [2, 3737, 3559, 3257, 3, 17890, 30338, 12924, 2591, 1927, 5066, 2132, 1956, 3171, 11505, 20013, 17670, 17, 6898, 3737, 3559, 3257, 16, 2559, 1927, 8566, 1985, 2568, 3024, 18, 3798, 3]}, "items": [{"id": "p_1983", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_1984", "content": "rapamycin [SEP] Conversion to rapamycin immunosuppression in renal transplant recipients: report of an ", "tokenized_content": [2, 11100, 3, 7309, 1942, 11100, 15858, 1922, 4604, 5192, 9336, 30, 3809, 1927, 1925, 3]}, "items": [{"id": "p_1984", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1985", "content": "RAPA [SEP] BACKGROUND: The aim of this study is to evaluate the effects of RAPA conversion in patients undergoing cyclosporine (CsA) or tacroli", "tokenized_content": [2, 29513, 3, 3872, 30, 1920, 3774, 1927, 2052, 2161, 1977, 1942, 4323, 1920, 2564, 1927, 29513, 7309, 1922, 2132, 7258, 21002, 12, 12993, 13, 2014, 9214, 2226, 1033, 3]}, "items": [{"id": "p_1985", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1986", "content": "cyclosporine [SEP]  evaluate the effects of RAPA conversion in patients undergoing cyclosporine (CsA) or tacrolimus (Tac) toxicity. METHODS: Twenty renal trans", "tokenized_content": [2, 21002, 3, 4323, 1920, 2564, 1927, 29513, 7309, 1922, 2132, 7258, 21002, 12, 12993, 13, 2014, 21801, 12, 9214, 13, 5532, 18, 2860, 30, 7639, 4604, 2127, 3]}, "items": [{"id": "p_1986", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1987", "content": "CsA [SEP] effects of RAPA conversion in patients undergoing cyclosporine (CsA) or tacrolimus (Tac) toxicity. METHODS: Twenty renal transplant", "tokenized_content": [2, 12993, 3, 2564, 1927, 29513, 7309, 1922, 2132, 7258, 21002, 12, 12993, 13, 2014, 21801, 12, 9214, 13, 5532, 18, 2860, 30, 7639, 4604, 5192, 3]}, "items": [{"id": "p_1987", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_1988", "content": "tacrolimus [SEP] of RAPA conversion in patients undergoing cyclosporine (CsA) or tacrolimus (Tac) toxicity. METHODS: Twenty renal transplant recipients wer", "tokenized_content": [2, 21801, 3, 1927, 29513, 7309, 1922, 2132, 7258, 21002, 12, 12993, 13, 2014, 21801, 12, 9214, 13, 5532, 18, 2860, 30, 7639, 4604, 5192, 9336, 22210, 3]}, "items": [{"id": "p_1988", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1989", "content": "Tac [SEP] ersion in patients undergoing cyclosporine (CsA) or tacrolimus (Tac) toxicity. METHODS: Twenty renal transplant recipients were swi", "tokenized_content": [2, 9214, 3, 22877, 2001, 1922, 2132, 7258, 21002, 12, 12993, 13, 2014, 21801, 12, 9214, 13, 5532, 18, 2860, 30, 7639, 4604, 5192, 9336, 1985, 19532, 3]}, "items": [{"id": "p_1989", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1990", "content": "toxicity [SEP] n in patients undergoing cyclosporine (CsA) or tacrolimus (Tac) toxicity. METHODS: Twenty renal transplant recipients were switched to f", "tokenized_content": [2, 5532, 3, 56, 1922, 2132, 7258, 21002, 12, 12993, 13, 2014, 21801, 12, 9214, 13, 5532, 18, 2860, 30, 7639, 4604, 5192, 9336, 1985, 15523, 1942, 48, 3]}, "items": [{"id": "p_1990", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1991", "content": "rapamycin [SEP]  Twenty renal transplant recipients were switched to fixed dose rapamycin (RAPA) (5 mg/day) 0 to 204 months posttransplant. Drug monitori", "tokenized_content": [2, 11100, 3, 7639, 4604, 5192, 9336, 1985, 15523, 1942, 4779, 3253, 11100, 12, 29513, 13, 12, 25, 2786, 19, 3007, 13, 20, 1942, 16368, 3221, 13918, 4043, 18, 2838, 8434, 3]}, "items": [{"id": "p_1991", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1992", "content": "nephrotoxicity [SEP] djust doses. The indications for switch were chronic CsA or Tac nephrotoxicity (12), acute CsA or Tac toxicity (3), severe facial dysmorphism ", "tokenized_content": [2, 27880, 3, 17224, 2892, 5312, 18, 1920, 11615, 1958, 6195, 1985, 3724, 12993, 2014, 9214, 27880, 12, 2369, 13, 16, 3939, 12993, 2014, 9214, 5532, 12, 23, 13, 16, 4010, 3]}, "items": [{"id": "p_1992", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1993", "content": "posttransplant lymphoproliferative disorder [SEP] , acute CsA or Tac toxicity (3), severe facial dysmorphism (2), posttransplant lymphoproliferative disorder (PTLD) in remission (2), and hepatotoxicity in 1. Follow-up is ", "tokenized_content": [2, 13918, 4043, 3541, 23283, 4770, 3, 16, 3939, 12993, 2014, 9214, 5532, 12, 23, 13, 16, 4010, 9567, 26906, 28119, 12, 22, 13, 16, 13918, 4043, 3541, 23283, 4770, 12, 3]}, "items": [{"id": "p_1993", "content": "Lymphoproliferative Disorders [SEP] Disorders characterized by proliferation of lymphoid tissue, general or unspecified.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3541, 23283, 4414, 3, 4414, 4378, 2007, 4031, 1927, 11751, 2960, 16, 3335, 2014, 29628, 2828, 18, 3]}]}
{"query": {"id": "q_1994", "content": "PTLD [SEP] l dysmorphism (2), posttransplant lymphoproliferative disorder (PTLD) in remission (2), and hepatotoxicity in 1. Follow-up is 7 to 2", "tokenized_content": [2, 4401, 4184, 3, 54, 26906, 28119, 12, 22, 13, 16, 13918, 4043, 3541, 23283, 4770, 12, 4401, 4184, 13, 1922, 10221, 12, 22, 13, 16, 1930, 24126, 1922, 21, 18, 3]}, "items": [{"id": "p_1994", "content": "Lymphoproliferative Disorders [SEP] Disorders characterized by proliferation of lymphoid tissue, general or unspecified.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3541, 23283, 4414, 3, 4414, 4378, 2007, 4031, 1927, 11751, 2960, 16, 3335, 2014, 29628, 2828, 18, 3]}]}
{"query": {"id": "q_1995", "content": "hepatotoxicity [SEP] plant lymphoproliferative disorder (PTLD) in remission (2), and hepatotoxicity in 1. Follow-up is 7 to 24 months. RESULTS: In the 12 patients ", "tokenized_content": [2, 24126, 3, 4496, 3541, 23283, 4770, 12, 4401, 4184, 13, 1922, 10221, 12, 22, 13, 16, 1930, 24126, 1922, 21, 18, 2396, 17, 2353, 1977, 27, 1942, 2686, 3221, 18, 3]}, "items": [{"id": "p_1995", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1996", "content": "creatinine [SEP] hronic nephrotoxicity there was a significant decrease in serum creatinine [233+/-34 to 210+/-56 micromol/liter (P<0.05) at 6 months]. Fac", "tokenized_content": [2, 9374, 3, 3668, 3490, 27880, 2276, 1982, 43, 2228, 3714, 1922, 3256, 9374, 37, 19598, 15, 19, 17, 3540, 1942, 12348, 15, 19, 17, 4489, 25385, 19, 4154, 12, 58, 3]}, "items": [{"id": "p_1996", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_1997", "content": "pneumonia [SEP] ients. No relapse of PTLD was observed. Five patients developed pneumonia (two Pneumocystis carinii pneumonia, one infectious mononucleos", "tokenized_content": [2, 7868, 3, 10116, 4905, 1036, 18, 2239, 8834, 1927, 4401, 4184, 1982, 2528, 18, 3628, 2132, 3530, 7868, 12, 2288, 6097, 22972, 2279, 11566, 1033, 7868, 16, 2340, 7465, 29932, 3]}, "items": [{"id": "p_1997", "content": "Pneumonia [SEP] Inflammation of any part, segment or lobe, of the lung parenchyma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7868, 3, 4531, 1927, 2967, 3131, 16, 5367, 2014, 9581, 16, 1927, 1920, 3614, 15214, 18, 3]}]}
{"query": {"id": "q_1998", "content": "Pneumocystis carinii pneumonia [SEP] se of PTLD was observed. Five patients developed pneumonia (two Pneumocystis carinii pneumonia, one infectious mononucleosis with polyclonal PTLD lung infiltr", "tokenized_content": [2, 6097, 22972, 2279, 11566, 1033, 7868, 3, 2058, 1927, 4401, 4184, 1982, 2528, 18, 3628, 2132, 3530, 7868, 12, 2288, 6097, 22972, 2279, 11566, 1033, 7868, 16, 2340, 7465, 29932, 3]}, "items": [{"id": "p_1998", "content": "Pneumonia, Pneumocystis [SEP] A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachyp", "score": 1, "type": null, "tokenized_content": [2, 7868, 16, 6097, 22972, 3, 43, 5352, 2573, 1922, 5209, 6966, 1922, 30297, 2014, 3054, 29956, 5270, 2132, 2014, 5969, 16, 4378, 2007, 18461, 16, 12762, 2085, 3]}]}
{"query": {"id": "q_1999", "content": "infectious mononucleosis [SEP] ts developed pneumonia (two Pneumocystis carinii pneumonia, one infectious mononucleosis with polyclonal PTLD lung infiltrate) and two had bronchiolitis", "tokenized_content": [2, 7465, 29932, 2475, 3, 4894, 3530, 7868, 12, 2288, 6097, 22972, 2279, 11566, 1033, 7868, 16, 2340, 7465, 29932, 2475, 1956, 9563, 4401, 4184, 3614, 19155, 13, 1930, 2288, 2430, 3]}, "items": [{"id": "p_1999", "content": "Infectious Mononucleosis [SEP] A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear w", "score": 1, "type": null, "tokenized_content": [2, 7465, 29932, 2475, 3, 43, 3059, 16, 3939, 2909, 5394, 4189, 2007, 1920, 22038, 17, 18852, 3413, 12, 25718, 24, 16, 2616, 13, 18, 2276, 1977, 1925, 2760, 1922, 12192, 65, 3]}]}
{"query": {"id": "q_2000", "content": "bronchiolitis obliterans [SEP] mononucleosis with polyclonal PTLD lung infiltrate) and two had bronchiolitis obliterans. There were no deaths. RAPA was discontinued in four patients, ", "tokenized_content": [2, 30149, 3678, 26462, 2075, 3, 29932, 2475, 1956, 9563, 4401, 4184, 3614, 19155, 13, 1930, 2288, 2430, 30149, 3678, 26462, 2075, 18, 2276, 1985, 2239, 7601, 18, 29513, 1982, 16087, 3]}, "items": [{"id": "p_2000", "content": "Bronchiolitis Obliterans [SEP] Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tis", "score": 1, "type": null, "tokenized_content": [2, 30149, 3678, 26462, 2075, 3, 4531, 1927, 1920, 30149, 1918, 4523, 1942, 1925, 12234, 3614, 2573, 18, 30149, 1918, 2032, 4378, 2007, 15711, 28258, 30152, 3]}]}
{"query": {"id": "q_2001", "content": "aphtous ulcers [SEP] ur patients, because of pneumonia in two, PTLD in one, and oral aphtous ulcers in one. RAPA levels were high (>15 ng/ml) in 7 of 13 (54%) pati", "tokenized_content": [2, 12274, 4575, 1957, 16225, 3, 3674, 2132, 16, 2882, 1927, 7868, 1922, 2288, 16, 4401, 4184, 1922, 2340, 16, 1930, 4726, 12274, 4575, 1957, 16225, 1922, 2340, 18, 29513, 2428, 3]}, "items": [{"id": "p_2001", "content": "Stomatitis, Aphthous [SEP] A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or mul", "score": 1, "type": null, "tokenized_content": [2, 9347, 6219, 16, 12274, 1963, 2080, 3, 43, 7457, 2573, 1927, 1920, 4726, 9680, 1927, 5435, 10383, 18, 2176, 1977, 4378, 2007, 2858, 4511, 20428, 4518, 16, 2957, 2014, 2556, 3]}]}
{"query": {"id": "q_2002", "content": "levodopa [SEP] Worsening of levodopa-induced dyskinesias by motor and mental tasks.", "tokenized_content": [2, 26723, 3, 15473, 1927, 26723, 17, 2719, 3890, 26682, 1036, 2007, 4842, 1930, 5018, 6840, 18, 3]}, "items": [{"id": "p_2002", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2003", "content": "dyskinesias [SEP] Worsening of levodopa-induced dyskinesias by motor and mental tasks.", "tokenized_content": [2, 3890, 26682, 1036, 3, 15473, 1927, 26723, 17, 2719, 3890, 26682, 1036, 2007, 4842, 1930, 5018, 6840, 18, 3]}, "items": [{"id": "p_2003", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2004", "content": "Parkinson's disease [SEP] Ten patients who had Parkinson's disease with disabling dyskinesia were included in this study to evalua", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 5656, 2132, 2746, 2430, 10124, 11, 61, 2573, 1956, 27606, 3890, 26682, 1985, 3063, 1922, 2052, 2161, 1942, 2711, 1019, 3]}, "items": [{"id": "p_2004", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2005", "content": "dyskinesia [SEP] Ten patients who had Parkinson's disease with disabling dyskinesia were included in this study to evaluate the role of mental (men", "tokenized_content": [2, 3890, 26682, 3, 5656, 2132, 2746, 2430, 10124, 11, 61, 2573, 1956, 27606, 3890, 26682, 1985, 3063, 1922, 2052, 2161, 1942, 4323, 1920, 2770, 1927, 5018, 12, 3925, 3]}, "items": [{"id": "p_2005", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2006", "content": "apomorphine [SEP] kinesia following administration of an effective single dose of apomorphine. Compared with the score at rest (1.3+/-0.3), a significant agg", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 16892, 2126, 2894, 4183, 1927, 1925, 3655, 2957, 3253, 1927, 11466, 12492, 11119, 7969, 2912, 18, 2452, 1956, 1920, 3593, 2019, 6172, 12, 21, 3]}, "items": [{"id": "p_2006", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_2007", "content": "Structural and functional impairment of mitochondria [SEP] Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: suppression of cy", "tokenized_content": [2, 4346, 1930, 3183, 6159, 1927, 6489, 3, 4346, 1930, 3183, 6159, 1927, 6489, 1922, 25622, 7898, 17, 2719, 14141, 1922, 2518, 30, 6412, 1927, 6002, 3]}, "items": [{"id": "p_2007", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_2008", "content": "adriamycin [SEP] Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: suppression of cytochrome c oxi", "tokenized_content": [2, 25622, 7898, 3, 4346, 1930, 3183, 6159, 1927, 6489, 1922, 25622, 7898, 17, 2719, 14141, 1922, 2518, 30, 6412, 1927, 9387, 45, 2833, 1033, 3]}, "items": [{"id": "p_2008", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2009", "content": "cardiomyopathy [SEP] and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: suppression of cytochrome c oxidase II gene expression", "tokenized_content": [2, 14141, 3, 1930, 3183, 6159, 1927, 6489, 1922, 25622, 7898, 17, 2719, 14141, 1922, 2518, 30, 6412, 1927, 9387, 45, 10488, 2890, 2359, 2294, 3]}, "items": [{"id": "p_2009", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2010", "content": "adriamycin [SEP] The use of adriamycin (ADR) in cancer chemotherapy has been limited due to its cumula", "tokenized_content": [2, 25622, 7898, 3, 1920, 2485, 1927, 25622, 7898, 12, 17645, 13, 1922, 2539, 5318, 2258, 2252, 3892, 2810, 1942, 2496, 7394, 5617, 3]}, "items": [{"id": "p_2010", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2011", "content": "ADR [SEP] The use of adriamycin (ADR) in cancer chemotherapy has been limited due to its cumulative ", "tokenized_content": [2, 17645, 3, 1920, 2485, 1927, 25622, 7898, 12, 17645, 13, 1922, 2539, 5318, 2258, 2252, 3892, 2810, 1942, 2496, 8274, 3]}, "items": [{"id": "p_2011", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2012", "content": "cancer [SEP] The use of adriamycin (ADR) in cancer chemotherapy has been limited due to its cumulative cardiovascu", "tokenized_content": [2, 2539, 3, 1920, 2485, 1927, 25622, 7898, 12, 17645, 13, 1922, 2539, 5318, 2258, 2252, 3892, 2810, 1942, 2496, 8274, 21129, 10916, 18021, 3]}, "items": [{"id": "p_2012", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_2013", "content": "cardiovascular toxicity [SEP] ) in cancer chemotherapy has been limited due to its cumulative cardiovascular toxicity. Earlier observations that ADR interacts with mitochondrial cyt", "tokenized_content": [2, 5321, 5532, 3, 13, 1922, 2539, 5318, 2258, 2252, 3892, 2810, 1942, 2496, 8274, 5321, 5532, 18, 5556, 5184, 1988, 17645, 9034, 1956, 4596, 2702, 3]}, "items": [{"id": "p_2013", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_2014", "content": "cardiovascular arrhythmias [SEP] Our results indicated that 1) treatment of mice with ADR caused cardiovascular arrhythmias characterized by bradycardia, extension of ventricular depolari", "tokenized_content": [2, 5321, 16934, 3, 2342, 2274, 3391, 1988, 21, 13, 2311, 1927, 2518, 1956, 17645, 4189, 5321, 16934, 4378, 2007, 26192, 16, 7140, 1927, 6493, 10722, 1033, 3]}, "items": [{"id": "p_2014", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2015", "content": "bradycardia [SEP] ice with ADR caused cardiovascular arrhythmias characterized by bradycardia, extension of ventricular depolarization time (tQRS), and failu", "tokenized_content": [2, 26192, 3, 7133, 1956, 17645, 4189, 5321, 16934, 4378, 2007, 26192, 16, 7140, 1927, 6493, 14030, 2367, 12, 28949, 5675, 13, 16, 1930, 3627, 1032, 3]}, "items": [{"id": "p_2015", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2016", "content": "swelling [SEP] dy weight cumulative dose); 2) the heart mitochondria underwent swelling, fusion, dissolution, and/or disruption of mitochondrial crista", "tokenized_content": [2, 11438, 3, 6433, 3388, 8274, 3253, 13, 31, 22, 13, 1920, 4003, 6489, 5468, 11438, 16, 5289, 16, 15059, 16, 1930, 19, 2014, 7561, 1927, 4596, 29023, 1019, 3]}, "items": [{"id": "p_2016", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2017", "content": "mitochondrial structural and functional impairment [SEP] deteriorating effects of ADR on cardiovascular function involve mitochondrial structural and functional impairment.", "tokenized_content": [2, 4596, 4346, 1930, 3183, 6159, 3, 10901, 2287, 2564, 1927, 17645, 1990, 5321, 2347, 8156, 4596, 4346, 1930, 3183, 6159, 18, 3]}, "items": [{"id": "p_2017", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_2018", "content": "bradycardia [SEP] Enhanced bradycardia induced by beta-adrenoceptor antagonists in rats pretreated wit", "tokenized_content": [2, 26192, 3, 4256, 26192, 2719, 2007, 4666, 17, 25090, 10515, 1922, 3615, 12152, 16086, 3]}, "items": [{"id": "p_2018", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2019", "content": "isoniazid [SEP] nduced by beta-adrenoceptor antagonists in rats pretreated with isoniazid.", "tokenized_content": [2, 28383, 3, 8026, 2418, 2007, 4666, 17, 25090, 10515, 1922, 3615, 12152, 1956, 28383, 18, 3]}, "items": [{"id": "p_2019", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_2020", "content": "isoniazid [SEP] High doses of isoniazid increase hypotension induced by vasodilators and change the acc", "tokenized_content": [2, 28383, 3, 2149, 5312, 1927, 28383, 2760, 16453, 2719, 2007, 28194, 1036, 1930, 3185, 1920, 2280, 3]}, "items": [{"id": "p_2020", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_2021", "content": "hypotension [SEP] High doses of isoniazid increase hypotension induced by vasodilators and change the accompanying reflex tach", "tokenized_content": [2, 16453, 3, 2149, 5312, 1927, 28383, 2760, 16453, 2719, 2007, 28194, 1036, 1930, 3185, 1920, 15252, 11573, 12762, 3]}, "items": [{"id": "p_2021", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2022", "content": "tachycardia [SEP] sion induced by vasodilators and change the accompanying reflex tachycardia to bradycardia, an interaction attributed to decreased synthesi", "tokenized_content": [2, 17397, 3, 5998, 1916, 2719, 2007, 28194, 1036, 1930, 3185, 1920, 15252, 11573, 17397, 1942, 26192, 16, 1925, 2835, 6898, 1942, 3261, 11685, 1033, 3]}, "items": [{"id": "p_2022", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_2023", "content": "bradycardia [SEP]  vasodilators and change the accompanying reflex tachycardia to bradycardia, an interaction attributed to decreased synthesis of brain gamm", "tokenized_content": [2, 26192, 3, 28194, 1036, 1930, 3185, 1920, 15252, 11573, 17397, 1942, 26192, 16, 1925, 2835, 6898, 1942, 3261, 4271, 1927, 3068, 6741, 3]}, "items": [{"id": "p_2023", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2024", "content": "gamma-aminobutyric acid [SEP] rdia, an interaction attributed to decreased synthesis of brain gamma-aminobutyric acid (GABA). In the present study, the possible enhancement by isoni", "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 8695, 2126, 16, 1925, 2835, 6898, 1942, 3261, 4271, 1927, 3068, 7034, 17, 29093, 2687, 12, 7992, 13, 18, 1922, 1920, 2481, 2161, 16, 1920, 3]}, "items": [{"id": "p_2024", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_2025", "content": "GABA [SEP] ibuted to decreased synthesis of brain gamma-aminobutyric acid (GABA). In the present study, the possible enhancement by isoniazid o", "tokenized_content": [2, 7992, 3, 22306, 2013, 1942, 3261, 4271, 1927, 3068, 7034, 17, 29093, 2687, 12, 7992, 13, 18, 1922, 1920, 2481, 2161, 16, 1920, 3216, 7489, 2007, 28383, 57, 3]}, "items": [{"id": "p_2025", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_2026", "content": "chloralose [SEP] enoceptor antagonists was determined in rats anaesthetised with chloralose-urethane. Isoniazid significantly increased bradycardia after p", "tokenized_content": [2, 4891, 20807, 4127, 3, 2066, 20245, 1924, 10515, 1982, 3180, 1922, 3615, 12023, 24964, 1919, 1956, 4891, 20807, 4127, 17, 19221, 2516, 18, 28383, 2567, 2502, 26192, 2256, 58, 3]}, "items": [{"id": "p_2026", "content": "Chloralose [SEP] A derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most co", "score": 1, "type": null, "tokenized_content": [2, 4891, 20807, 4127, 3, 43, 10533, 1927, 4891, 1923, 27864, 1988, 1982, 2251, 1966, 43, 28514, 2308, 2258, 2252, 8403, 2007, 20404, 1930, 2253, 3655, 4195, 18, 2496, 2501, 2081, 3]}]}
{"query": {"id": "q_2027", "content": "urethane [SEP] ntagonists was determined in rats anaesthetised with chloralose-urethane. Isoniazid significantly increased bradycardia after propranolo", "tokenized_content": [2, 19221, 2516, 3, 20503, 3827, 11110, 1973, 1982, 3180, 1922, 3615, 12023, 24964, 1919, 1956, 4891, 20807, 4127, 17, 19221, 2516, 18, 28383, 2567, 2502, 26192, 2256, 12031, 4296, 1037, 3]}, "items": [{"id": "p_2027", "content": "Urethane [SEP] Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis", "score": 1, "type": null, "tokenized_content": [2, 19221, 2516, 3, 29128, 9969, 5899, 1988, 1977, 2222, 2251, 1966, 43, 15748, 16111, 18, 2176, 2258, 2222, 2252, 2251, 1966, 1925, 6129, 1922, 6805, 4271, 3]}]}
{"query": {"id": "q_2028", "content": "Isoniazid [SEP]  was determined in rats anaesthetised with chloralose-urethane. Isoniazid significantly increased bradycardia after propranolol, pindolol", "tokenized_content": [2, 28383, 3, 1982, 3180, 1922, 3615, 12023, 24964, 1919, 1956, 4891, 20807, 4127, 17, 19221, 2516, 18, 28383, 2567, 2502, 26192, 2256, 21395, 16, 8701, 22389, 6012, 1024, 3]}, "items": [{"id": "p_2028", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_2029", "content": "propranolol [SEP] e-urethane. Isoniazid significantly increased bradycardia after propranolol, pindolol, labetalol and atenolol, as well as after clonidine, ", "tokenized_content": [2, 21395, 3, 47, 17, 19221, 2516, 18, 28383, 2567, 2502, 26192, 2256, 21395, 16, 8701, 22389, 6012, 1024, 16, 2857, 3949, 1945, 1930, 30280, 11873, 6012, 1024, 16, 1966, 2486, 3]}, "items": [{"id": "p_2029", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2030", "content": "pindolol [SEP] soniazid significantly increased bradycardia after propranolol, pindolol, labetalol and atenolol, as well as after clonidine, but not af", "tokenized_content": [2, 8701, 22389, 6012, 1024, 3, 9337, 7736, 1960, 2567, 2502, 26192, 2256, 21395, 16, 8701, 22389, 6012, 1024, 16, 2857, 3949, 1945, 1930, 30280, 11873, 6012, 1024, 16, 1966, 2486, 3]}, "items": [{"id": "p_2030", "content": "Pindolol [SEP] A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic ", "score": 1, "type": null, "tokenized_content": [2, 8701, 22389, 6012, 1024, 3, 43, 11224, 21140, 4666, 14580, 12, 13672, 4666, 17, 10515, 13, 18, 2176, 1977, 2447, 17, 21129, 4127, 25419, 2185, 1930, 2258, 7598, 26638, 1947, 21870, 3]}]}
{"query": {"id": "q_2031", "content": "labetalol [SEP] ignificantly increased bradycardia after propranolol, pindolol, labetalol and atenolol, as well as after clonidine, but not after hexamet", "tokenized_content": [2, 2857, 3949, 1945, 3, 12046, 2077, 2031, 1954, 2502, 26192, 2256, 21395, 16, 8701, 22389, 6012, 1024, 16, 2857, 3949, 1945, 1930, 30280, 11873, 6012, 1024, 16, 1966, 2486, 1966, 3]}, "items": [{"id": "p_2031", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_2032", "content": "atenolol [SEP] ncreased bradycardia after propranolol, pindolol, labetalol and atenolol, as well as after clonidine, but not after hexamethonium or car", "tokenized_content": [2, 30280, 11873, 6012, 1024, 3, 16122, 18013, 1919, 26192, 2256, 21395, 16, 8701, 22389, 6012, 1024, 16, 2857, 3949, 1945, 1930, 30280, 11873, 6012, 1024, 16, 1966, 2486, 1966, 2256, 3]}, "items": [{"id": "p_2032", "content": "Atenolol [SEP] A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative ino", "score": 1, "type": null, "tokenized_content": [2, 30280, 11873, 6012, 1024, 3, 43, 21129, 4127, 25419, 2185, 4666, 17, 21, 13672, 14580, 19705, 3879, 1930, 10397, 2551, 1942, 21395, 16, 2308, 2979, 43, 3136, 26848, 3]}]}
{"query": {"id": "q_2033", "content": "clonidine [SEP] propranolol, pindolol, labetalol and atenolol, as well as after clonidine, but not after hexamethonium or carbachol. Enhancement was not ", "tokenized_content": [2, 26596, 3, 21395, 16, 8701, 22389, 6012, 1024, 16, 2857, 3949, 1945, 1930, 30280, 11873, 6012, 1024, 16, 1966, 2486, 1966, 2256, 26596, 16, 2308, 2084, 2256, 7142, 10758, 15414, 3]}, "items": [{"id": "p_2033", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_2034", "content": "hexamethonium [SEP] betalol and atenolol, as well as after clonidine, but not after hexamethonium or carbachol. Enhancement was not observed in rats pretreated w", "tokenized_content": [2, 7142, 10758, 15414, 3, 4666, 6012, 1024, 1930, 30280, 11873, 6012, 1024, 16, 1966, 2486, 1966, 2256, 26596, 16, 2308, 2084, 2256, 7142, 10758, 15414, 2014, 28940, 18, 7489, 1982, 3]}, "items": [{"id": "p_2034", "content": "Hexamethonium [SEP] A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gast", "score": 1, "type": null, "tokenized_content": [2, 7142, 10758, 15414, 3, 43, 20239, 13908, 8151, 3868, 6656, 1942, 1966, 1920, 29183, 12516, 1935, 14580, 18, 2176, 1977, 7865, 14504, 2037, 1920, 6215, 3]}]}
{"query": {"id": "q_2035", "content": "carbachol [SEP] lol, as well as after clonidine, but not after hexamethonium or carbachol. Enhancement was not observed in rats pretreated with methylatr", "tokenized_content": [2, 28940, 3, 3004, 1024, 16, 1966, 2486, 1966, 2256, 26596, 16, 2308, 2084, 2256, 7142, 10758, 15414, 2014, 28940, 18, 7489, 1982, 2084, 2528, 1922, 3615, 12152, 1956, 4963, 12078, 3]}, "items": [{"id": "p_2035", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_2036", "content": "methylatropine [SEP] carbachol. Enhancement was not observed in rats pretreated with methylatropine or previously vagotomised. These results are compatible with in", "tokenized_content": [2, 4963, 12078, 2011, 2053, 3, 28940, 18, 7489, 1982, 2084, 2528, 1922, 3615, 12152, 1956, 4963, 12078, 2011, 2053, 2014, 3024, 7715, 11957, 3495, 18, 2144, 2274, 2032, 11290, 1956, 3]}, "items": [{"id": "p_2036", "content": "methylatropine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4963, 12078, 2011, 2053, 3, 3]}]}
{"query": {"id": "q_2037", "content": "folic acid [SEP] Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)", "tokenized_content": [2, 19731, 2687, 3, 28367, 3880, 2455, 1927, 19731, 2687, 2256, 2838, 6387, 4565, 12, 19731, 2687, 1930, 9741, 13, 3]}, "items": [{"id": "p_2037", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_2038", "content": "SLE [SEP] Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)", "tokenized_content": [2, 4565, 3, 28367, 3880, 2455, 1927, 19731, 2687, 2256, 2838, 6387, 4565, 12, 19731, 2687, 1930, 9741, 13, 3]}, "items": [{"id": "p_2038", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_2039", "content": "epilepsy [SEP] c activity of folic acid after drug induces SLE (folic acid and epilepsy)", "tokenized_content": [2, 9741, 3, 45, 2455, 1927, 19731, 2687, 2256, 2838, 6387, 4565, 12, 19731, 2687, 1930, 9741, 13, 3]}, "items": [{"id": "p_2039", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2040", "content": "folic acid [SEP] OBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women befo", "tokenized_content": [2, 19731, 2687, 3, 4470, 30, 1942, 2161, 1920, 2495, 1927, 19731, 2687, 17, 3165, 5738, 20760, 8746, 1922, 16304, 3089, 1998, 15282, 3]}, "items": [{"id": "p_2040", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_2041", "content": "epileptic [SEP] effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rat", "tokenized_content": [2, 16304, 3, 2495, 1927, 19731, 2687, 17, 3165, 5738, 20760, 8746, 1922, 16304, 3089, 3119, 1930, 2409, 5284, 1922, 3238, 1942, 3415, 1920, 3067, 3]}, "items": [{"id": "p_2041", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2042", "content": "birth defects [SEP] d during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects. STUDY DESIGN: First a random", "tokenized_content": [2, 5043, 6007, 3, 46, 2409, 5284, 1922, 3238, 1942, 3415, 1920, 2769, 1927, 4346, 5043, 6007, 1930, 9741, 17, 2712, 4159, 2564, 18, 2161, 3036, 30, 2561, 43, 3332, 3]}, "items": [{"id": "p_2042", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_2043", "content": "epilepsy [SEP]  in order to determine the rate of structural birth defects and epilepsy-related side effects. STUDY DESIGN: First a randomised trial, l", "tokenized_content": [2, 9741, 3, 1922, 3238, 1942, 3415, 1920, 2769, 1927, 4346, 5043, 6007, 1930, 9741, 17, 2712, 4159, 2564, 18, 2161, 3036, 30, 2561, 43, 12090, 3046, 16, 54, 3]}, "items": [{"id": "p_2043", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2044", "content": "cleft lip [SEP] conception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizure", "tokenized_content": [2, 14649, 3178, 3, 13413, 3047, 18, 2340, 16304, 10440, 7866, 43, 12203, 1956, 14649, 3178, 1930, 19471, 18, 3741, 2774, 5065, 1956, 43, 4377, 1927, 11015, 3]}, "items": [{"id": "p_2044", "content": "Cleft Lip [SEP] Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is", "score": 1, "type": null, "tokenized_content": [2, 14649, 3178, 3, 9901, 7374, 1922, 1920, 5199, 3178, 2597, 1920, 15813, 8057, 2055, 16300, 1942, 27399, 1956, 1920, 15780, 7922, 9305, 8057, 2408, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_2045", "content": "seizures [SEP] eft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. Thi", "tokenized_content": [2, 10060, 3, 8485, 1031, 3178, 1930, 19471, 18, 3741, 2774, 5065, 1956, 43, 4377, 1927, 10060, 2256, 1920, 10796, 1916, 14132, 3047, 2193, 3741, 5738, 20760, 18, 7566, 3]}, "items": [{"id": "p_2045", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2046", "content": "carbamazepine [SEP] n. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th w", "tokenized_content": [2, 30315, 3, 56, 18, 2052, 2950, 17, 2476, 17, 4156, 16304, 10440, 1982, 2868, 10446, 2007, 30315, 1930, 43, 19731, 2687, 12, 21, 2786, 13, 17, 3165, 5738, 20760, 2037, 3]}, "items": [{"id": "p_2046", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_2047", "content": "status epilepticus [SEP] ing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnan", "tokenized_content": [2, 3642, 16304, 1957, 3, 30393, 5738, 20760, 2037, 1920, 25673, 2982, 1927, 10879, 18, 4693, 3530, 3642, 16304, 1957, 1930, 3690, 3601, 1927, 5510, 13711, 19216, 7019, 18, 3656, 4297, 3]}, "items": [{"id": "p_2047", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_2048", "content": "systemic lupus erythematodes [SEP] station. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth. CONCLUSIONS: The epilepti", "tokenized_content": [2, 5510, 13711, 19216, 7019, 3, 9212, 18, 4693, 3530, 3642, 16304, 1957, 1930, 3690, 3601, 1927, 5510, 13711, 19216, 7019, 18, 3656, 5284, 14974, 1956, 24267, 18, 4355, 30, 1920, 3]}, "items": [{"id": "p_2048", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_2049", "content": "stillbirth [SEP] ptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth. CONCLUSIONS: The epileptic pregnant patient's autoimmune disea", "tokenized_content": [2, 24267, 3, 4401, 18995, 1927, 5510, 13711, 19216, 7019, 18, 3656, 5284, 14974, 1956, 24267, 18, 4355, 30, 1920, 16304, 7808, 2774, 11, 61, 8904, 2445, 1019, 3]}, "items": [{"id": "p_2049", "content": "Stillbirth [SEP] The event that a FETUS is born dead or stillborn.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24267, 3, 1920, 4817, 1988, 43, 15722, 1977, 8813, 9535, 2014, 3974, 23419, 18, 3]}]}
{"query": {"id": "q_2050", "content": "autoimmune disease [SEP]  with stillbirth. CONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barr", "tokenized_content": [2, 8904, 2573, 3, 1956, 24267, 18, 4355, 30, 1920, 16304, 7808, 2774, 11, 61, 8904, 2573, 12, 6226, 2838, 17, 2719, 13711, 13, 2578, 4293, 1920, 2877, 17, 3068, 18852, 3]}, "items": [{"id": "p_2050", "content": "Autoimmune Diseases [SEP] Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are ", "score": 1, "type": null, "tokenized_content": [2, 8904, 3902, 3, 4414, 1988, 2032, 4378, 2007, 1920, 3372, 1927, 3788, 1988, 9793, 1956, 4423, 3878, 2014, 3743, 7917, 2094, 1988, 2032, 3]}]}
{"query": {"id": "q_2051", "content": "lupus [SEP] She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth. CONCLUSIONS", "tokenized_content": [2, 13711, 3, 4693, 3530, 3642, 16304, 1957, 1930, 3690, 3601, 1927, 5510, 13711, 19216, 7019, 18, 3656, 5284, 14974, 1956, 24267, 18, 4355, 3]}, "items": [{"id": "p_2051", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_2052", "content": "epileptic seizures [SEP] l without any autoimmune disease, did not increase the risk for epileptic seizures.", "tokenized_content": [2, 16304, 10060, 3, 54, 2979, 2967, 8904, 2573, 16, 2811, 2084, 2760, 1920, 2565, 1958, 16304, 10060, 18, 3]}, "items": [{"id": "p_2052", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2053", "content": "cisapride [SEP] Effects of cisapride on symptoms and postcibal small-bowel motor function in patient", "tokenized_content": [2, 5848, 21358, 2261, 3, 2564, 1927, 5848, 21358, 2261, 1990, 3601, 1930, 27236, 26073, 1024, 2858, 17, 9472, 4842, 2347, 1922, 2774, 3]}, "items": [{"id": "p_2053", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_2054", "content": "irritable bowel syndrome [SEP] ptoms and postcibal small-bowel motor function in patients with irritable bowel syndrome.", "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 4401, 18995, 1930, 27236, 26073, 1024, 2858, 17, 9472, 4842, 2347, 1922, 2132, 1956, 5262, 5678, 9472, 4741, 18, 3]}, "items": [{"id": "p_2054", "content": "Irritable Bowel Syndrome [SEP] A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or", "score": 1, "type": null, "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 43, 4770, 1956, 3724, 2014, 7457, 12401, 3601, 2979, 43, 4021, 18021, 1031, 10383, 18, 2052, 2625, 1977, 4378, 2007, 3724, 2014, 3]}]}
{"query": {"id": "q_2055", "content": "Irritable bowel syndrome [SEP] BACKGROUND: Irritable bowel syndrome is a common cause of abdominal pain and discomfort and may be r", "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 3872, 30, 5262, 5678, 9472, 4741, 1977, 43, 3059, 3936, 1927, 6900, 3594, 1930, 15335, 1930, 2278, 1998, 60, 3]}, "items": [{"id": "p_2055", "content": "Irritable Bowel Syndrome [SEP] A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or", "score": 1, "type": null, "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 43, 4770, 1956, 3724, 2014, 7457, 12401, 3601, 2979, 43, 4021, 18021, 1031, 10383, 18, 2052, 2625, 1977, 4378, 2007, 3724, 2014, 3]}]}
{"query": {"id": "q_2056", "content": "abdominal pain [SEP] BACKGROUND: Irritable bowel syndrome is a common cause of abdominal pain and discomfort and may be related to disordered gastrointestina", "tokenized_content": [2, 6900, 3594, 3, 3872, 30, 5262, 5678, 9472, 4741, 1977, 43, 3059, 3936, 1927, 6900, 3594, 1930, 15335, 1930, 2278, 1998, 2712, 1942, 13885, 6858, 2879, 2158, 4058, 3]}, "items": [{"id": "p_2056", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_2057", "content": "disordered gastrointestinal motility [SEP] on cause of abdominal pain and discomfort and may be related to disordered gastrointestinal motility. Our aim was to assess the effects of long-term treatment with ", "tokenized_content": [2, 13885, 8375, 9254, 3, 1990, 3936, 1927, 6900, 3594, 1930, 15335, 1930, 2278, 1998, 2712, 1942, 13885, 8375, 9254, 18, 2342, 3774, 1982, 1942, 2634, 1920, 2564, 1927, 2815, 17, 3]}, "items": [{"id": "p_2057", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_2058", "content": "cisapride [SEP] ess the effects of long-term treatment with a prokinetic agent, cisapride, on postprandial jejunal motility and symptoms in the irritable", "tokenized_content": [2, 5848, 21358, 2261, 3, 4023, 1920, 2564, 1927, 2815, 17, 2576, 2311, 1956, 43, 1965, 24590, 2002, 5899, 16, 5848, 21358, 2261, 16, 1990, 19210, 30498, 9254, 1930, 3601, 1922, 3]}, "items": [{"id": "p_2058", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_2059", "content": "irritable bowel syndrome [SEP] cisapride, on postprandial jejunal motility and symptoms in the irritable bowel syndrome (IBS). METHODS: Thirty-eight patients with IBS (constipation-pr", "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 5848, 21358, 2261, 16, 1990, 19210, 30498, 9254, 1930, 3601, 1922, 1920, 5262, 5678, 9472, 4741, 12, 14956, 13, 18, 2860, 30, 9942, 17, 5066, 3]}, "items": [{"id": "p_2059", "content": "Irritable Bowel Syndrome [SEP] A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or", "score": 1, "type": null, "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 43, 4770, 1956, 3724, 2014, 7457, 12401, 3601, 2979, 43, 4021, 18021, 1031, 10383, 18, 2052, 2625, 1977, 4378, 2007, 3724, 2014, 3]}]}
{"query": {"id": "q_2060", "content": "IBS [SEP]  jejunal motility and symptoms in the irritable bowel syndrome (IBS). METHODS: Thirty-eight patients with IBS (constipation-predomi", "tokenized_content": [2, 14956, 3, 30498, 9254, 1930, 3601, 1922, 1920, 5262, 5678, 9472, 4741, 12, 14956, 13, 18, 2860, 30, 9942, 17, 5066, 2132, 1956, 14956, 12, 19618, 17, 5642, 1033, 3]}, "items": [{"id": "p_2060", "content": "Irritable Bowel Syndrome [SEP] A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or", "score": 1, "type": null, "tokenized_content": [2, 5262, 5678, 9472, 4741, 3, 43, 4770, 1956, 3724, 2014, 7457, 12401, 3601, 2979, 43, 4021, 18021, 1031, 10383, 18, 2052, 2625, 1977, 4378, 2007, 3724, 2014, 3]}]}
{"query": {"id": "q_2061", "content": "constipation [SEP]  bowel syndrome (IBS). METHODS: Thirty-eight patients with IBS (constipation-predominant, n = 17; diarrhoea-predominant, n = 21) underwent 2", "tokenized_content": [2, 19618, 3, 9472, 4741, 12, 14956, 13, 18, 2860, 30, 9942, 17, 5066, 2132, 1956, 14956, 12, 19618, 17, 6136, 16, 56, 33, 2752, 31, 20998, 17, 6136, 16, 56, 3]}, "items": [{"id": "p_2061", "content": "Constipation [SEP] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER", "score": 1, "type": null, "tokenized_content": [2, 19618, 3, 21587, 2014, 4571, 30034, 1927, 18610, 18, 2144, 3601, 2032, 2458, 1956, 43, 5386, 1927, 5092, 16, 2710, 2330, 6096, 6832, 3]}]}
{"query": {"id": "q_2062", "content": "diarrhoea [SEP] irty-eight patients with IBS (constipation-predominant, n = 17; diarrhoea-predominant, n = 21) underwent 24-h ambulatory jejunal manometr", "tokenized_content": [2, 20998, 3, 3166, 3145, 17, 5066, 2132, 1956, 14956, 12, 19618, 17, 6136, 16, 56, 33, 2752, 31, 20998, 17, 6136, 16, 56, 33, 2900, 13, 5468, 2686, 17, 50, 3]}, "items": [{"id": "p_2062", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_2063", "content": "Diarrhoea [SEP] sapride versus placebo (P < 0.05); pretreatment, 62 +/- 19 mm]. Diarrhoea-predominant IBS patients had a higher pain score after cisaprid", "tokenized_content": [2, 20998, 3, 9235, 20332, 1021, 4072, 5936, 12, 58, 32, 20, 18, 2914, 13, 31, 9111, 16, 5374, 15, 19, 17, 2282, 2489, 39, 18, 20998, 17, 6136, 14956, 2132, 3]}, "items": [{"id": "p_2063", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_2064", "content": "pain [SEP] GROUND: Irritable bowel syndrome is a common cause of abdominal pain and discomfort and may be related to disordered gastrointestina", "tokenized_content": [2, 3594, 3, 7406, 30, 5262, 5678, 9472, 4741, 1977, 43, 3059, 3936, 1927, 6900, 3594, 1930, 15335, 1930, 2278, 1998, 2712, 1942, 13885, 6858, 2879, 2158, 4058, 3]}, "items": [{"id": "p_2064", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2065", "content": "Cisapride [SEP] us placebo (P < 0.05); pretreatment, 67 +/- 19 mm]. CONCLUSION: Cisapride affects jejunal contraction characteristics and some symptoms i", "tokenized_content": [2, 5848, 21358, 2261, 3, 2022, 5936, 12, 58, 32, 20, 18, 2914, 13, 31, 9111, 16, 4838, 15, 19, 17, 2282, 2489, 39, 18, 4180, 30, 5848, 21358, 2261, 6886, 3]}, "items": [{"id": "p_2065", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_2066", "content": "Clarithromycin [SEP] Clarithromycin-induced ventricular tachycardia.", "tokenized_content": [2, 6932, 20402, 3, 6932, 20402, 17, 2719, 6493, 17397, 18, 3]}, "items": [{"id": "p_2066", "content": "Clarithromycin [SEP] A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibi", "score": 1, "type": null, "tokenized_content": [2, 6932, 20402, 3, 43, 8762, 18801, 4905, 4116, 2002, 23929, 2261, 7267, 3595, 2037, 22925, 1988, 1977, 3500, 3316, 43, 5386, 1927, 11679, 18, 2176, 2112, 2439, 1033, 3]}]}
{"query": {"id": "q_2067", "content": "ventricular tachycardia [SEP] Clarithromycin-induced ventricular tachycardia.", "tokenized_content": [2, 6493, 17397, 3, 6932, 20402, 17, 2719, 6493, 17397, 18, 3]}, "items": [{"id": "p_2067", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_2068", "content": "Clarithromycin [SEP] Clarithromycin is a relatively new macrolide antibiotic that offers twice-dail", "tokenized_content": [2, 6932, 20402, 3, 6932, 20402, 1977, 43, 4322, 2814, 23929, 2261, 7267, 1988, 9874, 6470, 17, 23708, 1024, 3]}, "items": [{"id": "p_2068", "content": "Clarithromycin [SEP] A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibi", "score": 1, "type": null, "tokenized_content": [2, 6932, 20402, 3, 43, 8762, 18801, 4905, 4116, 2002, 23929, 2261, 7267, 3595, 2037, 22925, 1988, 1977, 3500, 3316, 43, 5386, 1927, 11679, 18, 2176, 2112, 2439, 1033, 3]}]}
{"query": {"id": "q_2069", "content": "macrolide [SEP] Clarithromycin is a relatively new macrolide antibiotic that offers twice-daily dosing. It differs from eryt", "tokenized_content": [2, 23929, 2261, 3, 6932, 20402, 1977, 43, 4322, 2814, 23929, 2261, 7267, 1988, 9874, 6470, 17, 4692, 10654, 18, 2176, 11457, 2037, 2668, 2355, 3]}, "items": [{"id": "p_2069", "content": "Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ", "score": 1, "type": null, "tokenized_content": [2, 23929, 3726, 3, 43, 2210, 1927, 3868, 17514, 21924, 13153, 4300, 5333, 2007, 4659, 7140, 1927, 3137, 24682, 1036, 3637, 2301, 2460, 43, 3103, 12, 2357, 3]}]}
{"query": {"id": "q_2070", "content": "erythromycin [SEP] lide antibiotic that offers twice-daily dosing. It differs from erythromycin only in the methylation of the hydroxyl group at position 6. Al", "tokenized_content": [2, 22925, 3, 13096, 1021, 7267, 1988, 9874, 6470, 17, 4692, 10654, 18, 2176, 11457, 2037, 22925, 2444, 1922, 1920, 5547, 1927, 1920, 9420, 2210, 2019, 3507, 26, 18, 1969, 3]}, "items": [{"id": "p_2070", "content": "Erythromycin [SEP] A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active componen", "score": 1, "type": null, "tokenized_content": [2, 22925, 3, 43, 14027, 14882, 7267, 23929, 2261, 4152, 2007, 22874, 6549, 1936, 1957, 18, 22925, 43, 1977, 3311, 2496, 3044, 3500, 3309, 1917, 3]}]}
{"query": {"id": "q_2071", "content": "gastroenteritis [SEP] e side-effect profile of erythromycin is established, including gastroenteritis and interactions with other drugs subject to hepatic mixed-func", "tokenized_content": [2, 28189, 3, 47, 4159, 17, 2495, 5174, 1927, 22925, 1977, 4379, 16, 2710, 28189, 1930, 3719, 1956, 2303, 4195, 5198, 1942, 6095, 4985, 17, 2277, 1030, 3]}, "items": [{"id": "p_2071", "content": "Gastroenteritis [SEP] INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including", "score": 1, "type": null, "tokenized_content": [2, 28189, 3, 4531, 1927, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 5092, 1927, 28189, 2032, 3086, 2710, 3]}]}
{"query": {"id": "q_2072", "content": "macrolides [SEP] ic mixed-function oxidase metabolism, experience with the newer macrolides is still being recorded. Cardiotoxicity has been demonstrated a", "tokenized_content": [2, 23929, 3726, 3, 3996, 4985, 17, 2347, 10488, 4714, 16, 4848, 1956, 1920, 18012, 23929, 3726, 1977, 3974, 3301, 4562, 18, 30490, 2258, 2252, 3161, 43, 3]}, "items": [{"id": "p_2072", "content": "Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ", "score": 1, "type": null, "tokenized_content": [2, 23929, 3726, 3, 43, 2210, 1927, 3868, 17514, 21924, 13153, 4300, 5333, 2007, 4659, 7140, 1927, 3137, 24682, 1036, 3637, 2301, 2460, 43, 3103, 12, 2357, 3]}]}
{"query": {"id": "q_2073", "content": "Cardiotoxicity [SEP] , experience with the newer macrolides is still being recorded. Cardiotoxicity has been demonstrated after both intravenous and oral administr", "tokenized_content": [2, 30490, 3, 16, 4848, 1956, 1920, 18012, 23929, 3726, 1977, 3974, 3301, 4562, 18, 30490, 2258, 2252, 3161, 2256, 2321, 7307, 1930, 4726, 10473, 3]}, "items": [{"id": "p_2073", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2074", "content": "ventricular dysrhythmias [SEP] er been reported with the newer macrolides. We report a case of ventricular dysrhythmias that occurred after six therapeutic doses of clarithromycin. Th", "tokenized_content": [2, 6493, 3890, 5004, 4626, 15519, 3, 2668, 2252, 2568, 1956, 1920, 18012, 23929, 3726, 18, 2038, 3809, 43, 3087, 1927, 6493, 3890, 5004, 4626, 15519, 1988, 4807, 2256, 3798, 4272, 3]}, "items": [{"id": "p_2074", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2075", "content": "clarithromycin [SEP] cular dysrhythmias that occurred after six therapeutic doses of clarithromycin. The dysrhythmias resolved after discontinuation of the drug.", "tokenized_content": [2, 6932, 20402, 3, 6710, 1933, 3890, 5004, 4626, 15519, 1988, 4807, 2256, 3798, 4272, 5312, 1927, 6932, 20402, 18, 1920, 3890, 5004, 4626, 15519, 8397, 2256, 14775, 1927, 1920, 2838, 3]}, "items": [{"id": "p_2075", "content": "Clarithromycin [SEP] A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibi", "score": 1, "type": null, "tokenized_content": [2, 6932, 20402, 3, 43, 8762, 18801, 4905, 4116, 2002, 23929, 2261, 7267, 3595, 2037, 22925, 1988, 1977, 3500, 3316, 43, 5386, 1927, 11679, 18, 2176, 2112, 2439, 1033, 3]}]}
{"query": {"id": "q_2076", "content": "dysrhythmias [SEP] rted with the newer macrolides. We report a case of ventricular dysrhythmias that occurred after six therapeutic doses of clarithromycin. Th", "tokenized_content": [2, 3890, 5004, 4626, 15519, 3, 4341, 1919, 1956, 1920, 18012, 23929, 3726, 18, 2038, 3809, 43, 3087, 1927, 6493, 3890, 5004, 4626, 15519, 1988, 4807, 2256, 3798, 4272, 5312, 1927, 3]}, "items": [{"id": "p_2076", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2077", "content": "nephrogenic diabetes insipidus [SEP] Persistent nephrogenic diabetes insipidus following lithium therapy.", "tokenized_content": [2, 7737, 14845, 4032, 2346, 2049, 22291, 3, 7733, 7737, 14845, 4032, 2346, 2049, 22291, 2894, 14330, 3181, 18, 3]}, "items": [{"id": "p_2077", "content": "Diabetes Insipidus, Nephrogenic [SEP] A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to re", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 16, 7737, 14845, 3, 43, 3299, 2014, 5815, 4286, 15861, 4770, 4378, 2007, 7733, 29107, 6960, 1930, 14395, 7640, 1952, 6026, 18, 2052, 2625, 1977, 2810, 1942, 1964, 3]}]}
{"query": {"id": "q_2078", "content": "lithium [SEP] Persistent nephrogenic diabetes insipidus following lithium therapy.", "tokenized_content": [2, 14330, 3, 7733, 7737, 14845, 4032, 2346, 2049, 22291, 2894, 14330, 3181, 18, 3]}, "items": [{"id": "p_2078", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2079", "content": "dehydration [SEP] eport the case of a patient who developed severe hypernatraemic dehydration following a head injury. Ten years previously he had been diagn", "tokenized_content": [2, 16585, 3, 15751, 7446, 1920, 3087, 1927, 43, 2774, 2746, 3530, 4010, 4194, 5791, 5524, 4197, 16585, 2894, 43, 4469, 4047, 18, 5656, 2739, 3024, 2234, 2430, 2252, 2822, 3]}, "items": [{"id": "p_2079", "content": "Dehydration [SEP] The condition that results from excessive loss of water from a living organism.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16585, 3, 1920, 2625, 1988, 2274, 2037, 9122, 3257, 1927, 3224, 2037, 43, 5818, 9669, 18, 3]}]}
{"query": {"id": "q_2080", "content": "head injury [SEP] ent who developed severe hypernatraemic dehydration following a head injury. Ten years previously he had been diagnosed to have lithium-ind", "tokenized_content": [2, 4469, 4047, 3, 8496, 2746, 3530, 4010, 4194, 5791, 5524, 4197, 16585, 2894, 43, 4469, 4047, 18, 5656, 2739, 3024, 2234, 2430, 2252, 5377, 1942, 2162, 14330, 17, 2063, 3]}, "items": [{"id": "p_2080", "content": "Craniocerebral Trauma [SEP] Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structure", "score": 1, "type": null, "tokenized_content": [2, 21204, 2337, 13495, 7317, 7176, 3, 10242, 8209, 5884, 1920, 17586, 1989, 1930, 12179, 4061, 12, 51, 18, 47, 18, 16, 3068, 31, 13598, 12014, 31, 10286, 1918, 31, 1930, 2303, 3170, 3]}]}
{"query": {"id": "q_2081", "content": "lithium [SEP] head injury. Ten years previously he had been diagnosed to have lithium-induced nephrogenic diabetes insipidus, and lithium therapy had", "tokenized_content": [2, 14330, 3, 4469, 4047, 18, 5656, 2739, 3024, 2234, 2430, 2252, 5377, 1942, 2162, 14330, 17, 2719, 7737, 14845, 4032, 2346, 2049, 22291, 16, 1930, 14330, 3181, 2430, 3]}, "items": [{"id": "p_2081", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2082", "content": "nephrogenic diabetes insipidus [SEP]  years previously he had been diagnosed to have lithium-induced nephrogenic diabetes insipidus, and lithium therapy had been discontinued. He remained thirsty", "tokenized_content": [2, 7737, 14845, 4032, 2346, 2049, 22291, 3, 2739, 3024, 2234, 2430, 2252, 5377, 1942, 2162, 14330, 17, 2719, 7737, 14845, 4032, 2346, 2049, 22291, 16, 1930, 14330, 3181, 2430, 2252, 3]}, "items": [{"id": "p_2082", "content": "Diabetes Insipidus, Nephrogenic [SEP] A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to re", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 16, 7737, 14845, 3, 43, 3299, 2014, 5815, 4286, 15861, 4770, 4378, 2007, 7733, 29107, 6960, 1930, 14395, 7640, 1952, 6026, 18, 2052, 2625, 1977, 2810, 1942, 1964, 3]}]}
{"query": {"id": "q_2083", "content": "polyuric [SEP]  lithium therapy had been discontinued. He remained thirsty and polyuric despite cessation of lithium and investigations on admission sh", "tokenized_content": [2, 4286, 15861, 3, 14330, 3181, 2430, 2252, 16087, 18, 2234, 5410, 4053, 2156, 1012, 1930, 4286, 15861, 4281, 10975, 1927, 14330, 1930, 7873, 1990, 7682, 2044, 3]}, "items": [{"id": "p_2083", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_2084", "content": "vasopressin [SEP] on admission showed him to have normal osmoregulated thirst and vasopressin secretion, with clear evidence of nephrogenic diabetes insipidu", "tokenized_content": [2, 20671, 3, 1990, 7682, 2594, 13135, 1942, 2162, 2791, 9405, 14424, 2544, 4053, 2156, 1930, 20671, 5512, 16, 1956, 4021, 3095, 1927, 7737, 14845, 4032, 2346, 2049, 1960, 1032, 3]}, "items": [{"id": "p_2084", "content": "Vasopressins [SEP] Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balan", "score": 1, "type": null, "tokenized_content": [2, 20671, 1036, 3, 22576, 15766, 10224, 6988, 2007, 1920, 3366, 30338, 7056, 25818, 8362, 1927, 2136, 14976, 12, 3170, 10229, 1956, 3038, 13, 1942, 5741, 3224, 4641, 1928, 3]}]}
{"query": {"id": "q_2085", "content": "Lithium [SEP] cretion, with clear evidence of nephrogenic diabetes insipidus. Lithium induced nephrogenic diabetes insipidus is considered to be reve", "tokenized_content": [2, 14330, 3, 3478, 1929, 16, 1956, 4021, 3095, 1927, 7737, 14845, 4032, 2346, 2049, 22291, 18, 14330, 2719, 7737, 14845, 4032, 2346, 2049, 22291, 1977, 3311, 1942, 1998, 3084, 3]}, "items": [{"id": "p_2085", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2086", "content": "polyuria [SEP] idus is considered to be reversible on cessation of therapy but polyuria persisted in this patient for ten years after lithium was stopp", "tokenized_content": [2, 4286, 8754, 3, 2313, 1957, 1977, 3311, 1942, 1998, 10743, 1990, 10975, 1927, 3181, 2308, 4286, 8754, 14583, 1922, 2052, 2774, 1958, 5656, 2739, 2256, 14330, 1982, 6875, 1034, 3]}, "items": [{"id": "p_2086", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_2087", "content": "cardiotoxicity [SEP] Late cardiotoxicity after treatment for a malignant bone tumor.", "tokenized_content": [2, 30490, 3, 5058, 30490, 2256, 2311, 1958, 43, 6558, 3622, 2798, 18, 3]}, "items": [{"id": "p_2087", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2088", "content": "bone tumor [SEP] Late cardiotoxicity after treatment for a malignant bone tumor.", "tokenized_content": [2, 3622, 2798, 3, 5058, 30490, 2256, 2311, 1958, 43, 6558, 3622, 2798, 18, 3]}, "items": [{"id": "p_2088", "content": "Bone Neoplasms [SEP] Tumors or cancer located in bone tissue or specific BONES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3622, 15347, 3, 3861, 2014, 2539, 4810, 1922, 3622, 2960, 2014, 2487, 14153, 18, 3]}]}
{"query": {"id": "q_2089", "content": "bone tumors [SEP] rdiac function was assessed in long-term survivors of malignant bone tumors who were treated according to Rosen's T5 or T10 protocol, both ", "tokenized_content": [2, 3622, 3861, 3, 8695, 2126, 1030, 2347, 1982, 3683, 1922, 2815, 17, 2576, 9408, 1927, 6558, 3622, 3861, 2746, 1985, 2868, 3147, 1942, 25969, 11, 61, 24520, 2014, 6197, 1008, 3]}, "items": [{"id": "p_2089", "content": "Bone Neoplasms [SEP] Tumors or cancer located in bone tissue or specific BONES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3622, 15347, 3, 3861, 2014, 2539, 4810, 1922, 3622, 2960, 2014, 2487, 14153, 18, 3]}]}
{"query": {"id": "q_2090", "content": "Rosen's T5 or T10 protocol [SEP] urvivors of malignant bone tumors who were treated according to Rosen's T5 or T10 protocol, both including doxorubicin. Thirty-one patients, age 10-45 yea", "tokenized_content": [2, 25969, 11, 61, 24520, 2014, 6197, 1008, 4478, 3, 3674, 2165, 15525, 5675, 1927, 6558, 3622, 3861, 2746, 1985, 2868, 3147, 1942, 25969, 11, 61, 24520, 2014, 6197, 1008, 4478, 3]}, "items": [{"id": "p_2090", "content": "Rosen's T-10 protocol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25969, 11, 61, 62, 17, 2119, 4478, 3, 3]}]}
{"query": {"id": "q_2091", "content": "doxorubicin [SEP] treated according to Rosen's T5 or T10 protocol, both including doxorubicin. Thirty-one patients, age 10-45 years (median age 17.8 years) w", "tokenized_content": [2, 12377, 3, 2868, 3147, 1942, 25969, 11, 61, 24520, 2014, 6197, 1008, 4478, 16, 2321, 2710, 12377, 18, 9942, 17, 2340, 2132, 16, 2632, 2119, 17, 3607, 2739, 12, 4181, 3]}, "items": [{"id": "p_2091", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2092", "content": "cardiac toxicity [SEP]  radionuclide angiography. Eighteen of 31 (58%) patients showed cardiac toxicity, defined as having one or more of the following abnormalities: ", "tokenized_content": [2, 4435, 5532, 3, 29428, 11676, 18, 20461, 1927, 3470, 12, 4804, 9, 13, 2132, 2594, 4435, 5532, 16, 3608, 1966, 4537, 2340, 2014, 2253, 1927, 1920, 2894, 6754, 30, 3]}, "items": [{"id": "p_2092", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2093", "content": "ventricular arrhythmias [SEP] r more of the following abnormalities: late potentials, complex ventricular arrhythmias, left ventricular dilation, decreased shortening fraction, or d", "tokenized_content": [2, 6493, 16934, 3, 60, 2253, 1927, 1920, 2894, 6754, 30, 5058, 9322, 16, 2796, 6493, 16934, 16, 3506, 6493, 16470, 16, 3261, 14177, 3906, 16, 2014, 46, 3]}, "items": [{"id": "p_2093", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2094", "content": "ventricular dilation [SEP] alities: late potentials, complex ventricular arrhythmias, left ventricular dilation, decreased shortening fraction, or decreased ejection fraction.", "tokenized_content": [2, 6493, 16470, 3, 15356, 3237, 30, 5058, 9322, 16, 2796, 6493, 16934, 16, 3506, 6493, 16470, 16, 3261, 14177, 3906, 16, 2014, 3261, 13854, 3906, 18, 3]}, "items": [{"id": "p_2094", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_2095", "content": "cardiac abnormalities [SEP] ning fraction, or decreased ejection fraction. The incidence of cardiac abnormalities increased with length of follow-up (P< or = .05). No correlatio", "tokenized_content": [2, 4435, 6754, 3, 12117, 1029, 3906, 16, 2014, 3261, 13854, 3906, 18, 1920, 4332, 1927, 4435, 6754, 2502, 1956, 3471, 1927, 2396, 17, 2353, 12, 58, 32, 2014, 33, 18, 3]}, "items": [{"id": "p_2095", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_2096", "content": "cardiotoxicity [SEP] decreased in all patients. The incidence of doxorubicin-induced cardiotoxicity is high and increases with follow-up, irrespective of cumulativ", "tokenized_content": [2, 30490, 3, 3261, 1922, 2136, 2132, 18, 1920, 4332, 1927, 12377, 17, 2719, 30490, 1977, 2149, 1930, 4041, 1956, 2396, 17, 2353, 16, 12287, 1927, 7394, 5617, 2113, 3]}, "items": [{"id": "p_2096", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2097", "content": "Venous complications [SEP] Venous complications of midazolam versus diazepam.", "tokenized_content": [2, 8562, 5021, 3, 8562, 5021, 1927, 23380, 4072, 26079, 18, 3]}, "items": [{"id": "p_2097", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_2098", "content": "midazolam [SEP] Venous complications of midazolam versus diazepam.", "tokenized_content": [2, 23380, 3, 8562, 5021, 1927, 23380, 4072, 26079, 18, 3]}, "items": [{"id": "p_2098", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_2099", "content": "diazepam [SEP] Venous complications of midazolam versus diazepam.", "tokenized_content": [2, 26079, 3, 8562, 5021, 1927, 23380, 4072, 26079, 18, 3]}, "items": [{"id": "p_2099", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_2100", "content": "venous complications [SEP] Although some studies have suggested fewer venous complications are associated with midazolam than with diazepam for endoscopic", "tokenized_content": [2, 8562, 5021, 3, 2876, 2673, 2351, 2162, 3978, 7380, 8562, 5021, 2032, 2458, 1956, 23380, 2254, 1956, 26079, 1958, 10448, 3]}, "items": [{"id": "p_2100", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_2101", "content": "midazolam [SEP] s have suggested fewer venous complications are associated with midazolam than with diazepam for endoscopic procedures, this variable has", "tokenized_content": [2, 23380, 3, 61, 2162, 3978, 7380, 8562, 5021, 2032, 2458, 1956, 23380, 2254, 1956, 26079, 1958, 10448, 4869, 16, 2052, 4650, 2258, 3]}, "items": [{"id": "p_2101", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_2102", "content": "diazepam [SEP] er venous complications are associated with midazolam than with diazepam for endoscopic procedures, this variable has not been well docu", "tokenized_content": [2, 26079, 3, 2668, 8562, 5021, 2032, 2458, 1956, 23380, 2254, 1956, 26079, 1958, 10448, 4869, 16, 2052, 4650, 2258, 2084, 2252, 2486, 4289, 1032, 3]}, "items": [{"id": "p_2102", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_2103", "content": "Pain [SEP]  with 2% (1 of 60 patients) in the midazolam group (p < 0.002). Pain at the injection site occurred in 35% (22 of 62) of patients in", "tokenized_content": [2, 3594, 3, 1956, 22, 9, 12, 21, 1927, 3276, 2132, 13, 1922, 1920, 23380, 2210, 12, 58, 32, 20, 18, 9299, 13, 18, 3594, 2019, 1920, 4107, 3200, 4807, 1922, 3]}, "items": [{"id": "p_2103", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2104", "content": "Swelling [SEP]  with 7% (4 of 60 patients) in the midazolam group (p < 0.001). Swelling and warmth at the injection site were not significantly differe", "tokenized_content": [2, 11438, 3, 1956, 27, 9, 12, 24, 1927, 3276, 2132, 13, 1922, 1920, 23380, 2210, 12, 58, 32, 20, 18, 3472, 13, 18, 11438, 1930, 10142, 1963, 2019, 1920, 4107, 3]}, "items": [{"id": "p_2104", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2105", "content": "alcohol [SEP]  drug use, intravenous catheter site, dwell time of the needle, alcohol use, and pain during the injection had no effect on the inciden", "tokenized_content": [2, 4284, 3, 2838, 2485, 16, 7307, 8421, 3200, 16, 22708, 2367, 1927, 1920, 9351, 16, 4284, 2485, 16, 1930, 3594, 2409, 1920, 4107, 2430, 2239, 2495, 1990, 1920, 12869, 1917, 3]}, "items": [{"id": "p_2105", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_2106", "content": "pain [SEP] enous catheter site, dwell time of the needle, alcohol use, and pain during the injection had no effect on the incidence of venous c", "tokenized_content": [2, 3594, 3, 2066, 2080, 8421, 3200, 16, 22708, 2367, 1927, 1920, 9351, 16, 4284, 2485, 16, 1930, 3594, 2409, 1920, 4107, 2430, 2239, 2495, 1990, 1920, 4332, 1927, 8562, 45, 3]}, "items": [{"id": "p_2106", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2107", "content": "Tetany [SEP] Tetany and rhabdomyolysis due to surreptitious furosemide--importance ", "tokenized_content": [2, 9717, 5323, 3, 9717, 5323, 1930, 25369, 6892, 2810, 1942, 2250, 20483, 2572, 4836, 30509, 17, 17, 4737, 3]}, "items": [{"id": "p_2107", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_2108", "content": "rhabdomyolysis [SEP] Tetany and rhabdomyolysis due to surreptitious furosemide--importance of magnesium supple", "tokenized_content": [2, 25369, 6892, 3, 9717, 5323, 1930, 25369, 6892, 2810, 1942, 2250, 20483, 2572, 4836, 30509, 17, 17, 4737, 1927, 13148, 12902, 3]}, "items": [{"id": "p_2108", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_2109", "content": "furosemide [SEP] Tetany and rhabdomyolysis due to surreptitious furosemide--importance of magnesium supplementation.", "tokenized_content": [2, 30509, 3, 9717, 5323, 1930, 25369, 6892, 2810, 1942, 2250, 20483, 2572, 4836, 30509, 17, 17, 4737, 1927, 13148, 8746, 18, 3]}, "items": [{"id": "p_2109", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_2110", "content": "magnesium [SEP] d rhabdomyolysis due to surreptitious furosemide--importance of magnesium supplementation.", "tokenized_content": [2, 13148, 3, 46, 25369, 6892, 2810, 1942, 2250, 20483, 2572, 4836, 30509, 17, 17, 4737, 1927, 13148, 8746, 18, 3]}, "items": [{"id": "p_2110", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_2111", "content": "hypokalemia [SEP] Diuretics may induce hypokalemia, hypocalcemia and hypomagnesemia. While severe hypokalemia may ", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 25505, 2278, 4769, 14395, 7640, 1952, 6026, 16, 30201, 9358, 1930, 22750, 2531, 2124, 6026, 18, 2679, 4010, 14395, 7640, 1952, 6026, 2278, 3]}, "items": [{"id": "p_2111", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_2112", "content": "hypocalcemia [SEP] Diuretics may induce hypokalemia, hypocalcemia and hypomagnesemia. While severe hypokalemia may cause muscle w", "tokenized_content": [2, 30201, 9358, 3, 25505, 2278, 4769, 14395, 7640, 1952, 6026, 16, 30201, 9358, 1930, 22750, 2531, 2124, 6026, 18, 2679, 4010, 14395, 7640, 1952, 6026, 2278, 3936, 3760, 65, 3]}, "items": [{"id": "p_2112", "content": "Hypocalcemia [SEP] Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle an", "score": 1, "type": null, "tokenized_content": [2, 30201, 9358, 3, 3378, 1927, 1920, 2877, 5016, 4535, 2791, 18, 10952, 3951, 28704, 6515, 11780, 24064, 16, 2016, 15525, 2156, 2819, 11, 61, 2105, 16, 3760, 1925, 3]}]}
{"query": {"id": "q_2113", "content": "hypomagnesemia [SEP] Diuretics may induce hypokalemia, hypocalcemia and hypomagnesemia. While severe hypokalemia may cause muscle weakness, severe hyp", "tokenized_content": [2, 22750, 2531, 2124, 6026, 3, 25505, 2278, 4769, 14395, 7640, 1952, 6026, 16, 30201, 9358, 1930, 22750, 2531, 2124, 6026, 18, 2679, 4010, 14395, 7640, 1952, 6026, 2278, 3936, 3760, 3]}, "items": [{"id": "p_2113", "content": "Hypomagnesemia primary [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22750, 2531, 2124, 6026, 3065, 3, 3]}]}
{"query": {"id": "q_2114", "content": "muscle weakness [SEP] calcemia and hypomagnesemia. While severe hypokalemia may cause muscle weakness, severe hypomagnesemia is associated with muscle spasms and tet", "tokenized_content": [2, 3760, 12175, 3, 2799, 3847, 1930, 22750, 2531, 2124, 6026, 18, 2679, 4010, 14395, 7640, 1952, 6026, 2278, 3936, 3760, 12175, 16, 4010, 22750, 2531, 2124, 6026, 1977, 2458, 1956, 3]}, "items": [{"id": "p_2114", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_2115", "content": "muscle spasms [SEP] cause muscle weakness, severe hypomagnesemia is associated with muscle spasms and tetany which cannot be corrected by potassium and calcium s", "tokenized_content": [2, 3760, 24431, 1036, 3, 3936, 3760, 12175, 16, 4010, 22750, 2531, 2124, 6026, 1977, 2458, 1956, 3760, 24431, 1036, 1930, 9717, 5323, 2154, 5156, 1998, 7702, 2007, 9057, 1930, 5016, 3]}, "items": [{"id": "p_2115", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_2116", "content": "tetany [SEP] ess, severe hypomagnesemia is associated with muscle spasms and tetany which cannot be corrected by potassium and calcium supplementat", "tokenized_content": [2, 9717, 5323, 3, 4023, 16, 4010, 22750, 2531, 2124, 6026, 1977, 2458, 1956, 3760, 24431, 1036, 1930, 9717, 5323, 2154, 5156, 1998, 7702, 2007, 9057, 1930, 5016, 3029, 1926, 3]}, "items": [{"id": "p_2116", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_2117", "content": "potassium [SEP] ated with muscle spasms and tetany which cannot be corrected by potassium and calcium supplementation alone (1,2). Surreptitious diuretic", "tokenized_content": [2, 9057, 3, 30280, 1007, 1956, 3760, 24431, 1036, 1930, 9717, 5323, 2154, 5156, 1998, 7702, 2007, 9057, 1930, 5016, 8746, 4298, 12, 21, 16, 22, 13, 18, 2250, 20483, 2572, 3]}, "items": [{"id": "p_2117", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2118", "content": "calcium [SEP] le spasms and tetany which cannot be corrected by potassium and calcium supplementation alone (1,2). Surreptitious diuretic ingestion h", "tokenized_content": [2, 5016, 3, 2071, 24431, 1036, 1930, 9717, 5323, 2154, 5156, 1998, 7702, 2007, 9057, 1930, 5016, 8746, 4298, 12, 21, 16, 22, 13, 18, 2250, 20483, 2572, 4836, 26829, 14195, 3]}, "items": [{"id": "p_2118", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2119", "content": "obese [SEP] been described, mainly in women who are concerned that they are obese or edematous. Symptomatic hypokalemia has been reported in such", "tokenized_content": [2, 7379, 3, 2252, 2910, 16, 4994, 1922, 3089, 2746, 2032, 13629, 1988, 2611, 2032, 7379, 2014, 10144, 4575, 1957, 18, 9371, 14395, 7640, 1952, 6026, 2258, 2252, 2568, 1922, 2427, 3]}, "items": [{"id": "p_2119", "content": "Obesity [SEP] A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS i", "score": 1, "type": null, "tokenized_content": [2, 5379, 3, 43, 3642, 1956, 3362, 3388, 1988, 1977, 28655, 3538, 1920, 9630, 2014, 13321, 3388, 16, 5394, 2810, 1942, 4858, 1927, 5799, 27751, 51, 3]}]}
{"query": {"id": "q_2120", "content": "edematous [SEP] ribed, mainly in women who are concerned that they are obese or edematous. Symptomatic hypokalemia has been reported in such patients (3-", "tokenized_content": [2, 10144, 4575, 1957, 3, 5216, 1919, 16, 4994, 1922, 3089, 2746, 2032, 13629, 1988, 2611, 2032, 7379, 2014, 10144, 4575, 1957, 18, 9371, 14395, 7640, 1952, 6026, 2258, 2252, 2568, 3]}, "items": [{"id": "p_2120", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2121", "content": "magnesium [SEP] d in one case hypocalcemia was observed (8), but the effects of magnesium depletion were not noted in these patients.", "tokenized_content": [2, 13148, 3, 46, 1922, 2340, 3087, 30201, 9358, 1982, 2528, 12, 28, 13, 16, 2308, 1920, 2564, 1927, 13148, 6882, 1985, 2084, 5040, 1922, 2144, 2132, 18, 3]}, "items": [{"id": "p_2121", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_2122", "content": "glutamate [SEP] Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus ", "tokenized_content": [2, 7627, 3, 3257, 1927, 7627, 23922, 3616, 17, 3165, 3558, 1922, 1920, 3067, 17205, 10774, 3]}, "items": [{"id": "p_2122", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_2123", "content": "pilocarpine [SEP] lase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures.", "tokenized_content": [2, 7547, 7095, 12184, 3, 4800, 1021, 3616, 17, 3165, 3558, 1922, 1920, 3067, 17205, 10774, 2894, 7547, 7095, 12184, 17, 2719, 10060, 18, 3]}, "items": [{"id": "p_2123", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_2124", "content": "seizures [SEP]  neurons in the rat dentate gyrus following pilocarpine-induced seizures.", "tokenized_content": [2, 10060, 3, 3558, 1922, 1920, 3067, 17205, 10774, 2894, 7547, 7095, 12184, 17, 2719, 10060, 18, 3]}, "items": [{"id": "p_2124", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2125", "content": "glutamic acid [SEP] In situ hybridization methods were used to determine if glutamic acid decarboxylase (GAD) mRNA-containing neurons within the hilus of", "tokenized_content": [2, 18626, 2687, 3, 1922, 4740, 8335, 2860, 1985, 2251, 1942, 3415, 2647, 18626, 2687, 23922, 12, 10279, 13, 3616, 17, 3165, 3558, 2651, 1920, 18077, 1957, 1927, 3]}, "items": [{"id": "p_2125", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_2126", "content": "seizure [SEP] neurons within the hilus of the dentate gyrus are vulnerable to seizure-induced damage in a model of chronic seizures. Sprague-Dawley r", "tokenized_content": [2, 11015, 3, 3558, 2651, 1920, 18077, 1957, 1927, 1920, 17205, 10774, 2032, 11342, 1942, 11015, 17, 2719, 4293, 1922, 43, 2322, 1927, 3724, 10060, 18, 15684, 17, 15798, 60, 3]}, "items": [{"id": "p_2126", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2127", "content": "seizures [SEP]  are vulnerable to seizure-induced damage in a model of chronic seizures. Sprague-Dawley rats were injected intraperitoneally with piloc", "tokenized_content": [2, 10060, 3, 2032, 11342, 1942, 11015, 17, 2719, 4293, 1922, 43, 2322, 1927, 3724, 10060, 18, 15684, 17, 15798, 3615, 1985, 5624, 17245, 1956, 7547, 1994, 3]}, "items": [{"id": "p_2127", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2128", "content": "pilocarpine [SEP] zures. Sprague-Dawley rats were injected intraperitoneally with pilocarpine, and the hippocampal formation was studied histologically at 1,", "tokenized_content": [2, 7547, 7095, 12184, 3, 28546, 1918, 18, 15684, 17, 15798, 3615, 1985, 5624, 17245, 1956, 7547, 7095, 12184, 16, 1930, 1920, 7636, 3337, 1982, 3942, 15055, 2019, 21, 16, 3]}, "items": [{"id": "p_2128", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_2129", "content": "digoxigenin [SEP] induced seizures. In situ hybridization histochemistry, using a digoxigenin-labeled GAD cRNA probe, demonstrated a substantial decrease in ", "tokenized_content": [2, 4325, 2325, 22037, 3, 2719, 10060, 18, 1922, 4740, 8335, 2968, 7202, 16, 2193, 43, 4325, 2325, 22037, 17, 4993, 10279, 28080, 5598, 16, 3161, 43, 6317, 3714, 1922, 3]}, "items": [{"id": "p_2129", "content": "Digoxigenin [SEP] 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydro", "score": 1, "type": null, "tokenized_content": [2, 4325, 2325, 22037, 3, 23, 4666, 16, 2369, 4666, 16, 2607, 17, 5083, 8535, 10465, 17, 25, 4666, 17, 9429, 17, 2036, 12, 2950, 13, 17, 2066, 24710, 18, 43, 9429, 9356, 2261, 2154, 1977, 1920, 2260, 19602, 1916, 1927, 28815, 18, 2112, 1998, 2926, 2007, 3290, 3]}]}
{"query": {"id": "q_2130", "content": "cresyl violet [SEP]  time intervals. Additional neuronanatomical studies, including cresyl violet staining, neuronal degeneration methods, and histochemical loca", "tokenized_content": [2, 18401, 2199, 16917, 3, 2367, 6087, 18, 3281, 7428, 20660, 8204, 2351, 16, 2710, 18401, 2199, 16917, 4166, 16, 5121, 9174, 2860, 16, 1930, 27816, 2536, 1019, 3]}, "items": [{"id": "p_2130", "content": "cresyl violet [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18401, 2199, 16917, 3, 3]}]}
{"query": {"id": "q_2131", "content": "neuronal degeneration [SEP] nal neuronanatomical studies, including cresyl violet staining, neuronal degeneration methods, and histochemical localization of glial fibrillary aci", "tokenized_content": [2, 5121, 9174, 3, 13120, 7428, 20660, 8204, 2351, 16, 2710, 18401, 2199, 16917, 4166, 16, 5121, 9174, 2860, 16, 1930, 27816, 5363, 1927, 10786, 28724, 2000, 1033, 3]}, "items": [{"id": "p_2131", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_2132", "content": "neuronal loss [SEP] ase in the number of GAD mRNA-containing neurons was related to neuronal loss rather than to a decrease in GAD mRNA levels. The loss of GAD m", "tokenized_content": [2, 5121, 3257, 3, 28826, 1922, 1920, 2529, 1927, 10279, 3616, 17, 3165, 3558, 1982, 2712, 1942, 5121, 3257, 4356, 2254, 1942, 43, 3714, 1922, 10279, 3616, 2428, 18, 1920, 3257, 3]}, "items": [{"id": "p_2132", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_2133", "content": "GABA [SEP] bility appears to be another indication of the heterogeneity of GABA neurons.", "tokenized_content": [2, 7992, 3, 5088, 1999, 5107, 1942, 1998, 3741, 10331, 1927, 1920, 6808, 1927, 7992, 3558, 18, 3]}, "items": [{"id": "p_2133", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_2134", "content": "misoprostol [SEP] Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.", "tokenized_content": [2, 5682, 21898, 1945, 3, 6337, 2495, 1927, 5682, 21898, 1945, 1990, 20463, 2719, 4604, 5273, 1922, 7354, 2132, 18, 3]}, "items": [{"id": "p_2134", "content": "Misoprostol [SEP] A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and ", "score": 1, "type": null, "tokenized_content": [2, 5682, 21898, 1945, 3, 43, 6830, 5729, 1927, 4613, 15900, 11123, 18, 2176, 9300, 43, 3253, 17, 2712, 3523, 1927, 6319, 2687, 1930, 27979, 5512, 16, 1930, 3]}]}
{"query": {"id": "q_2135", "content": "indomethacin [SEP] Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.", "tokenized_content": [2, 20463, 3, 6337, 2495, 1927, 5682, 21898, 1945, 1990, 20463, 2719, 4604, 5273, 1922, 7354, 2132, 18, 3]}, "items": [{"id": "p_2135", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_2136", "content": "renal dysfunction [SEP] Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.", "tokenized_content": [2, 4604, 5273, 3, 6337, 2495, 1927, 5682, 21898, 1945, 1990, 20463, 2719, 4604, 5273, 1922, 7354, 2132, 18, 3]}, "items": [{"id": "p_2136", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2137", "content": "misoprostol [SEP] OBJECTIVE: To evaluate the possible protective effects of misoprostol on renal function in hospitalized elderly patients treated with", "tokenized_content": [2, 5682, 21898, 1945, 3, 4470, 30, 1942, 4323, 1920, 3216, 6337, 2564, 1927, 5682, 21898, 1945, 1990, 4604, 2347, 1922, 13123, 7354, 2132, 2868, 1956, 3]}, "items": [{"id": "p_2137", "content": "Misoprostol [SEP] A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and ", "score": 1, "type": null, "tokenized_content": [2, 5682, 21898, 1945, 3, 43, 6830, 5729, 1927, 4613, 15900, 11123, 18, 2176, 9300, 43, 3253, 17, 2712, 3523, 1927, 6319, 2687, 1930, 27979, 5512, 16, 1930, 3]}]}
{"query": {"id": "q_2138", "content": "indomethacin [SEP] on renal function in hospitalized elderly patients treated with indomethacin. METHODS: Forty-five hospitalized elderly patients (> 65 years ", "tokenized_content": [2, 20463, 3, 1990, 4604, 2347, 1922, 13123, 7354, 2132, 2868, 1956, 20463, 18, 2860, 30, 11270, 17, 3628, 13123, 7354, 2132, 12, 34, 4459, 2739, 3]}, "items": [{"id": "p_2138", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_2139", "content": "creatinine [SEP] mg/day (Group B). Laboratory variables of renal function [serum creatinine, blood urea nitrogen (BUN) and electrolytes] were evaluated bef", "tokenized_content": [2, 9374, 3, 2786, 19, 3007, 12, 2210, 44, 13, 18, 4542, 3832, 1927, 4604, 2347, 37, 3256, 9374, 16, 2877, 10505, 6634, 12, 20162, 13, 1930, 25308, 39, 1985, 3747, 3]}, "items": [{"id": "p_2139", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_2140", "content": "blood urea nitrogen [SEP] p B). Laboratory variables of renal function [serum creatinine, blood urea nitrogen (BUN) and electrolytes] were evaluated before initiation of the", "tokenized_content": [2, 2877, 10505, 6634, 3, 58, 44, 13, 18, 4542, 3832, 1927, 4604, 2347, 37, 3256, 9374, 16, 2877, 10505, 6634, 12, 20162, 13, 1930, 25308, 39, 1985, 3747, 3119, 6035, 3]}, "items": [{"id": "p_2140", "content": "Blood Urea Nitrogen [SEP] The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% highe", "score": 1, "type": null, "tokenized_content": [2, 2877, 10505, 6634, 3, 1920, 10505, 3110, 1927, 1920, 2877, 9662, 1922, 4430, 1927, 6634, 3919, 18, 3256, 12, 3582, 13, 10505, 6634, 1977, 3993, 2369, 9, 2149, 1021, 3]}]}
{"query": {"id": "q_2141", "content": "BUN [SEP] ables of renal function [serum creatinine, blood urea nitrogen (BUN) and electrolytes] were evaluated before initiation of therapy ", "tokenized_content": [2, 20162, 3, 4236, 1036, 1927, 4604, 2347, 37, 3256, 9374, 16, 2877, 10505, 6634, 12, 20162, 13, 1930, 25308, 39, 1985, 3747, 3119, 6035, 1927, 3181, 3]}, "items": [{"id": "p_2141", "content": "Blood Urea Nitrogen [SEP] The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% highe", "score": 1, "type": null, "tokenized_content": [2, 2877, 10505, 6634, 3, 1920, 10505, 3110, 1927, 1920, 2877, 9662, 1922, 4430, 1927, 6634, 3919, 18, 3256, 12, 3582, 13, 10505, 6634, 1977, 3993, 2369, 9, 2149, 1021, 3]}]}
{"query": {"id": "q_2142", "content": "pain [SEP] atment was estimated by the visual analog scale for severity of pain. RESULTS: Forty-two patients completed the study, 22 in Group A", "tokenized_content": [2, 3594, 3, 7513, 1939, 1982, 4185, 2007, 1920, 3737, 5729, 3536, 1958, 5155, 1927, 3594, 18, 2274, 30, 11270, 17, 2288, 2132, 5721, 1920, 2161, 16, 2950, 1922, 2210, 43, 3]}, "items": [{"id": "p_2142", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2143", "content": "Potassium [SEP] ly, compared to only 20 and 10% of Group B patients (p < 0.05). Potassium (K) increment of 0.6 mEq/l or more was observed in 50% of Group", "tokenized_content": [2, 9057, 3, 7518, 16, 2452, 1942, 2444, 2036, 1930, 2119, 9, 1927, 2210, 44, 2132, 12, 58, 32, 20, 18, 2914, 13, 18, 9057, 12, 53, 13, 16328, 1927, 20, 3]}, "items": [{"id": "p_2143", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2144", "content": "K [SEP] d to only 20 and 10% of Group B patients (p < 0.05). Potassium (K) increment of 0.6 mEq/l or more was observed in 50% of Group A,", "tokenized_content": [2, 53, 3, 46, 1942, 2444, 2036, 1930, 2119, 9, 1927, 2210, 44, 2132, 12, 58, 32, 20, 18, 2914, 13, 18, 9057, 12, 53, 13, 16328, 1927, 20, 18, 26, 3]}, "items": [{"id": "p_2144", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2145", "content": "renal dysfunction [SEP] lderly patients are at risk for developing indomethacin related renal dysfunction. Addition of misoprostol can minimize this renal impairment wit", "tokenized_content": [2, 4604, 5273, 3, 5091, 1915, 1954, 2132, 2032, 2019, 2565, 1958, 5130, 20463, 2712, 4604, 5273, 18, 2459, 1927, 5682, 21898, 1945, 2112, 9491, 2052, 4604, 6159, 16086, 3]}, "items": [{"id": "p_2145", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2146", "content": "renal impairment [SEP] ed renal dysfunction. Addition of misoprostol can minimize this renal impairment without affecting pain control.", "tokenized_content": [2, 4604, 6159, 3, 3347, 4604, 5273, 18, 2459, 1927, 5682, 21898, 1945, 2112, 9491, 2052, 4604, 6159, 2979, 7359, 3594, 2285, 18, 3]}, "items": [{"id": "p_2146", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2147", "content": "Nephrotoxic [SEP] Nephrotoxic effects of aminoglycoside treatment on renal protein reabsorpti", "tokenized_content": [2, 22994, 10605, 3, 22994, 10605, 2564, 1927, 23029, 8028, 2311, 1990, 4604, 2213, 1964, 8805, 12157, 1914, 3]}, "items": [{"id": "p_2147", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2148", "content": "aminoglycoside [SEP] Nephrotoxic effects of aminoglycoside treatment on renal protein reabsorption and accumulation.", "tokenized_content": [2, 23029, 8028, 3, 22994, 10605, 2564, 1927, 23029, 8028, 2311, 1990, 4604, 2213, 26287, 1930, 4858, 18, 3]}, "items": [{"id": "p_2148", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_2149", "content": "gentamicin [SEP] To quantify the effects of gentamicin, kanamycin and netilmicin on renal protein reabsorption and acc", "tokenized_content": [2, 17144, 3, 1942, 8730, 1920, 2564, 1927, 17144, 16, 19404, 1930, 3254, 1970, 4913, 1921, 1990, 4604, 2213, 26287, 1930, 2280, 3]}, "items": [{"id": "p_2149", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_2150", "content": "kanamycin [SEP] To quantify the effects of gentamicin, kanamycin and netilmicin on renal protein reabsorption and accumulation, ", "tokenized_content": [2, 19404, 3, 1942, 8730, 1920, 2564, 1927, 17144, 16, 19404, 1930, 3254, 1970, 4913, 1921, 1990, 4604, 2213, 26287, 1930, 4858, 16, 3]}, "items": [{"id": "p_2150", "content": "Kanamycin [SEP] Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major com", "score": 1, "type": null, "tokenized_content": [2, 19404, 3, 7267, 2796, 4152, 2007, 22874, 12916, 26984, 1972, 2002, 1957, 2037, 10405, 6072, 18, 12936, 23, 4178, 30, 19404, 43, 16, 1920, 3044, 2008, 3]}]}
{"query": {"id": "q_2151", "content": "netilmicin [SEP] To quantify the effects of gentamicin, kanamycin and netilmicin on renal protein reabsorption and accumulation, these drugs wer", "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 1942, 8730, 1920, 2564, 1927, 17144, 16, 19404, 1930, 3254, 1970, 4913, 1921, 1990, 4604, 2213, 26287, 1930, 4858, 16, 2144, 4195, 22210, 3]}, "items": [{"id": "p_2151", "content": "Netilmicin [SEP] Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear an", "score": 1, "type": null, "tokenized_content": [2, 3254, 1970, 4913, 1921, 3, 8762, 18801, 4905, 4116, 2002, 21, 17, 56, 17, 7843, 10533, 1927, 19149, 7928, 16, 1925, 23029, 8028, 7267, 1956, 4615, 2551, 1942, 17144, 16, 2308, 2941, 4352, 1925, 3]}]}
{"query": {"id": "q_2152", "content": "sodium [SEP] icroscopy of the glomerular endothelia, urinary measurements of sodium, potassium, endogenous lysozyme, N-acetyl-beta-D-glucosaminidas", "tokenized_content": [2, 5227, 3, 19778, 9672, 1927, 1920, 11655, 4579, 14007, 16, 7075, 4146, 1927, 5227, 16, 9057, 16, 5355, 18581, 16, 56, 17, 6894, 17, 4666, 17, 46, 17, 3351, 5360, 3]}, "items": [{"id": "p_2152", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2153", "content": "potassium [SEP] y of the glomerular endothelia, urinary measurements of sodium, potassium, endogenous lysozyme, N-acetyl-beta-D-glucosaminidase (NAG) as ", "tokenized_content": [2, 9057, 3, 67, 1927, 1920, 11655, 4579, 14007, 16, 7075, 4146, 1927, 5227, 16, 9057, 16, 5355, 18581, 16, 56, 17, 6894, 17, 4666, 17, 46, 17, 3351, 5360, 8547, 3]}, "items": [{"id": "p_2153", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2154", "content": "Gentamicin [SEP] ts of inulin clearance (GFR) were done in each treatment group. Gentamicin administration decreased diameter, density and shape of endothe", "tokenized_content": [2, 17144, 3, 4894, 1927, 1922, 3392, 7802, 12, 15316, 13, 1985, 5404, 1922, 2362, 2311, 2210, 18, 17144, 4183, 3261, 5483, 16, 3824, 1930, 5989, 1927, 4579, 1021, 3]}, "items": [{"id": "p_2154", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_2155", "content": "Kanamycin [SEP] decreased diameter, density and shape of endothelial fenestrae. Kanamycin and netilmicin appeared to have no effect at the dose used. All", "tokenized_content": [2, 19404, 3, 3261, 5483, 16, 3824, 1930, 5989, 1927, 5003, 28484, 10261, 1021, 18, 19404, 1930, 3254, 1970, 4913, 1921, 6209, 1942, 2162, 2239, 2495, 2019, 1920, 3253, 2251, 18, 3]}, "items": [{"id": "p_2155", "content": "Kanamycin [SEP] Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major com", "score": 1, "type": null, "tokenized_content": [2, 19404, 3, 7267, 2796, 4152, 2007, 22874, 12916, 26984, 1972, 2002, 1957, 2037, 10405, 6072, 18, 12936, 23, 4178, 30, 19404, 43, 16, 1920, 3044, 2008, 3]}]}
{"query": {"id": "q_2156", "content": "aminoglycosides [SEP] tilmicin appeared to have no effect at the dose used. All three aminoglycosides decreased GFR and increased urinary excretion of sodium and pot", "tokenized_content": [2, 23029, 17079, 3, 10935, 4913, 1921, 6209, 1942, 2162, 2239, 2495, 2019, 1920, 3253, 2251, 18, 2136, 2559, 23029, 17079, 3261, 15316, 1930, 2502, 7075, 11093, 1927, 5227, 1930, 2543, 3]}, "items": [{"id": "p_2156", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_2157", "content": "impairment of renal reabsorption [SEP]  as nephrotoxicants at glomerular and/or tubular level inducing impairment of renal reabsorption and accumulation of proteins.", "tokenized_content": [2, 6159, 1927, 4604, 26287, 3, 1966, 22994, 10605, 2356, 2019, 11655, 1930, 19, 2014, 11755, 2237, 7834, 6159, 1927, 4604, 26287, 1930, 4858, 1927, 2697, 18, 3]}, "items": [{"id": "p_2157", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2158", "content": "GYKI-41 099 [SEP] Pharmacology of GYKI-41 099 (chlorpropanol, Tobanum) a new potent beta-adrenergic antagonis", "tokenized_content": [2, 8415, 7369, 17, 4353, 7102, 1026, 3, 18374, 1927, 8415, 7369, 17, 4353, 7102, 1026, 12, 4891, 20194, 4296, 16, 7551, 24961, 13, 43, 2814, 6828, 4666, 17, 13672, 5605, 3]}, "items": [{"id": "p_2158", "content": "tobanum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7551, 24961, 3, 3]}]}
{"query": {"id": "q_2159", "content": "chlorpropanol [SEP] Pharmacology of GYKI-41 099 (chlorpropanol, Tobanum) a new potent beta-adrenergic antagonist.", "tokenized_content": [2, 4891, 20194, 4296, 3, 18374, 1927, 8415, 7369, 17, 4353, 7102, 1026, 12, 4891, 20194, 4296, 16, 7551, 24961, 13, 43, 2814, 6828, 4666, 17, 13672, 8151, 18, 3]}, "items": [{"id": "p_2159", "content": "tobanum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7551, 24961, 3, 3]}]}
{"query": {"id": "q_2160", "content": "Tobanum [SEP] Pharmacology of GYKI-41 099 (chlorpropanol, Tobanum) a new potent beta-adrenergic antagonist.", "tokenized_content": [2, 7551, 24961, 3, 18374, 1927, 8415, 7369, 17, 4353, 7102, 1026, 12, 4891, 20194, 4296, 16, 7551, 24961, 13, 43, 2814, 6828, 4666, 17, 13672, 8151, 18, 3]}, "items": [{"id": "p_2160", "content": "tobanum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7551, 24961, 3, 3]}]}
{"query": {"id": "q_2161", "content": "GYKI-41 099 [SEP] The compound GYKI-41 099, as a beta-adrenergic antagonist, is 3-8 times more potent than", "tokenized_content": [2, 8415, 7369, 17, 4353, 7102, 1026, 3, 1920, 3547, 8415, 7369, 17, 4353, 7102, 1026, 16, 1966, 43, 4666, 17, 13672, 8151, 16, 1977, 23, 17, 28, 3586, 2253, 6828, 3]}, "items": [{"id": "p_2161", "content": "tobanum [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7551, 24961, 3, 3]}]}
{"query": {"id": "q_2162", "content": "propranolol [SEP]  as a beta-adrenergic antagonist, is 3-8 times more potent than propranolol in vitro and in vivo. Its antiarrhythmic effectiveness surpasse", "tokenized_content": [2, 21395, 3, 1966, 43, 4666, 17, 13672, 8151, 16, 1977, 23, 17, 28, 3586, 2253, 6828, 2254, 21395, 1922, 3596, 1930, 1922, 3597, 18, 2496, 2246, 23246, 4913, 6001, 28520, 3]}, "items": [{"id": "p_2162", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2163", "content": "pindolol [SEP]  antiarrhythmic effectiveness surpasses that of propranolol and pindolol inhibiting the ouabain arrhythmia in dogs and cats. GYKI-41 900", "tokenized_content": [2, 8701, 22389, 6012, 1024, 3, 2246, 23246, 4913, 6001, 28520, 1918, 1988, 1927, 21395, 1930, 8701, 22389, 6012, 1024, 7918, 1920, 26274, 18346, 1922, 7894, 1930, 12408, 18, 8415, 7369, 3]}, "items": [{"id": "p_2163", "content": "Pindolol [SEP] A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic ", "score": 1, "type": null, "tokenized_content": [2, 8701, 22389, 6012, 1024, 3, 43, 11224, 21140, 4666, 14580, 12, 13672, 4666, 17, 10515, 13, 18, 2176, 1977, 2447, 17, 21129, 4127, 25419, 2185, 1930, 2258, 7598, 26638, 1947, 21870, 3]}]}
{"query": {"id": "q_2164", "content": "ouabain [SEP] eness surpasses that of propranolol and pindolol inhibiting the ouabain arrhythmia in dogs and cats. GYKI-41 900 has a negligible cardi", "tokenized_content": [2, 26274, 3, 2066, 1979, 28520, 1918, 1988, 1927, 21395, 1930, 8701, 22389, 6012, 1024, 7918, 1920, 26274, 18346, 1922, 7894, 1930, 12408, 18, 8415, 7369, 17, 4353, 13886, 2258, 43, 3]}, "items": [{"id": "p_2164", "content": "Ouabain [SEP] A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants ", "score": 1, "type": null, "tokenized_content": [2, 26274, 3, 43, 21129, 3849, 7533, 2261, 7600, 1927, 23120, 2217, 1930, 26175, 4079, 1921, 16, 2926, 2037, 1920, 9869, 1927, 4943, 18547, 1963, 1957, 24689, 1031, 1957, 1930, 2303, 4793, 3]}]}
{"query": {"id": "q_2165", "content": "arrhythmia [SEP] rpasses that of propranolol and pindolol inhibiting the ouabain arrhythmia in dogs and cats. GYKI-41 900 has a negligible cardiodepressant", "tokenized_content": [2, 18346, 3, 16454, 5590, 1918, 1988, 1927, 21395, 1930, 8701, 22389, 6012, 1024, 7918, 1920, 26274, 18346, 1922, 7894, 1930, 12408, 18, 8415, 7369, 17, 4353, 13886, 2258, 43, 12613, 3]}, "items": [{"id": "p_2165", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2166", "content": "Chorea [SEP] Chorea associated with oral contraception.", "tokenized_content": [2, 11418, 5376, 3, 11418, 5376, 2458, 1956, 4726, 21379, 18, 3]}, "items": [{"id": "p_2166", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_2167", "content": "oral contraception [SEP] Chorea associated with oral contraception.", "tokenized_content": [2, 4726, 21379, 3, 11418, 5376, 2458, 1956, 4726, 21379, 18, 3]}, "items": [{"id": "p_2167", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_2168", "content": "chorea [SEP] Three patients developed chorea while receiving oral contraceptives. Two were young patients wh", "tokenized_content": [2, 11418, 5376, 3, 2559, 2132, 3530, 11418, 5376, 2679, 5962, 4726, 25434, 18, 2288, 1985, 4201, 2132, 2003, 3]}, "items": [{"id": "p_2168", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_2169", "content": "oral contraceptives [SEP] Three patients developed chorea while receiving oral contraceptives. Two were young patients whose chorea developed long after trea", "tokenized_content": [2, 4726, 25434, 3, 2559, 2132, 3530, 11418, 5376, 2679, 5962, 4726, 25434, 18, 2288, 1985, 4201, 2132, 6098, 11418, 5376, 3530, 2815, 2256, 2171, 1019, 3]}, "items": [{"id": "p_2169", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_2170", "content": "amphetamine [SEP] oon after it had been discontinued. The third patient had acute amphetamine-induced chorea after prolonged oral contraception. Prolonged ad", "tokenized_content": [2, 19057, 3, 57, 1916, 2256, 2176, 2430, 2252, 16087, 18, 1920, 4563, 2774, 2430, 3939, 19057, 17, 2719, 11418, 5376, 2256, 7171, 4726, 21379, 18, 7171, 2041, 3]}, "items": [{"id": "p_2170", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2171", "content": "oral contraception [SEP] rd patient had acute amphetamine-induced chorea after prolonged oral contraception. Prolonged administration of female sex hormones is a possible ", "tokenized_content": [2, 4726, 21379, 3, 8695, 2774, 2430, 3939, 19057, 17, 2719, 11418, 5376, 2256, 7171, 4726, 21379, 18, 7171, 4183, 1927, 4232, 3486, 10224, 1977, 43, 3216, 3]}, "items": [{"id": "p_2171", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_2172", "content": "rheumatic fever [SEP]  cause of chorea in women who have not previously had chorea or rheumatic fever.", "tokenized_content": [2, 22806, 9087, 3, 3936, 1927, 11418, 5376, 1922, 3089, 2746, 2162, 2084, 3024, 2430, 11418, 5376, 2014, 22806, 9087, 18, 3]}, "items": [{"id": "p_2172", "content": "Rheumatic Fever [SEP] A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple foca", "score": 1, "type": null, "tokenized_content": [2, 22806, 9087, 3, 43, 18850, 2573, 6966, 1966, 43, 7083, 2549, 15208, 1927, 5024, 1956, 15746, 6085, 10864, 18, 2176, 1977, 4378, 2007, 3137, 3438, 1019, 3]}]}
{"query": {"id": "q_2173", "content": "ammonia [SEP] Reversal of ammonia coma in rats by L-dopa: a peripheral effect.", "tokenized_content": [2, 14880, 3, 12393, 1927, 14880, 22337, 1922, 3615, 2007, 54, 17, 19428, 30, 43, 5009, 2495, 18, 3]}, "items": [{"id": "p_2173", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_2174", "content": "coma [SEP] Reversal of ammonia coma in rats by L-dopa: a peripheral effect.", "tokenized_content": [2, 22337, 3, 12393, 1927, 14880, 22337, 1922, 3615, 2007, 54, 17, 19428, 30, 43, 5009, 2495, 18, 3]}, "items": [{"id": "p_2174", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_2175", "content": "L-dopa [SEP] Reversal of ammonia coma in rats by L-dopa: a peripheral effect.", "tokenized_content": [2, 54, 17, 19428, 3, 12393, 1927, 14880, 22337, 1922, 3615, 2007, 54, 17, 19428, 30, 43, 5009, 2495, 18, 3]}, "items": [{"id": "p_2175", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2176", "content": "Ammonia [SEP] Ammonia coma was produced in rats within 10 to 15 minutes of an intrape", "tokenized_content": [2, 14880, 3, 14880, 22337, 1982, 4152, 1922, 3615, 2651, 2119, 1942, 2461, 4814, 1927, 1925, 17817, 1021, 3]}, "items": [{"id": "p_2176", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_2177", "content": "coma [SEP] Ammonia coma was produced in rats within 10 to 15 minutes of an intraperiton", "tokenized_content": [2, 22337, 3, 14880, 22337, 1982, 4152, 1922, 3615, 2651, 2119, 1942, 2461, 4814, 1927, 1925, 10493, 8439, 3]}, "items": [{"id": "p_2177", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_2178", "content": "NH4CL [SEP] hin 10 to 15 minutes of an intraperitonealinjection of 1.7 mmol NH4CL. This coma was prevented with 1.68 mmol L-dopa given by gastric", "tokenized_content": [2, 29225, 3, 10220, 1022, 2119, 1942, 2461, 4814, 1927, 1925, 13006, 22468, 1927, 21, 18, 27, 6397, 29225, 18, 2052, 22337, 1982, 8715, 1956, 21, 18, 5117, 6397, 54, 17, 3]}, "items": [{"id": "p_2178", "content": "Ammonium Chloride [SEP] An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplatin", "score": 1, "type": null, "tokenized_content": [2, 11944, 9140, 3, 1925, 2687, 7649, 5899, 1988, 2258, 6324, 8846, 4905, 1930, 26829, 2564, 18, 2222, 2251, 1922, 22066, 1930, 27249, 1930, 1966, 43, 8220, 1922, 4260, 8516, 3]}]}
{"query": {"id": "q_2179", "content": "L-dopa [SEP] ction of 1.7 mmol NH4CL. This coma was prevented with 1.68 mmol L-dopa given by gastric intubation 15 minutes before the ammonium salt", "tokenized_content": [2, 54, 17, 19428, 3, 3369, 2001, 1927, 21, 18, 27, 6397, 29225, 18, 2052, 22337, 1982, 8715, 1956, 21, 18, 5117, 6397, 54, 17, 19428, 3258, 2007, 6319, 15686, 2461, 3]}, "items": [{"id": "p_2179", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2180", "content": "ammonium salt [SEP] 8 mmol L-dopa given by gastric intubation 15 minutes before the ammonium salt injection. The effect of L-dopa was correlated with a decrease ", "tokenized_content": [2, 11944, 7012, 3, 28, 6397, 54, 17, 19428, 3258, 2007, 6319, 15686, 2461, 4814, 3119, 1920, 11944, 7012, 4107, 18, 1920, 2495, 1927, 54, 17, 19428, 1982, 4374, 1956, 43, 3]}, "items": [{"id": "p_2180", "content": "Ammonium Compounds [SEP] Inorganic compounds that include a positively charged tetrahedral nitrogen (ammonium ion) as part of their structure. This class", "score": 1, "type": null, "tokenized_content": [2, 11944, 4300, 3, 13849, 4300, 1988, 3951, 43, 6629, 9516, 12470, 23265, 6634, 12, 11944, 4755, 13, 1966, 3131, 1927, 2310, 3170, 18, 2052, 2921, 3]}]}
{"query": {"id": "q_2181", "content": "ammonia [SEP] ect of L-dopa was correlated with a decrease in blood and brain ammonia, an increase in brain dopamine, and an increase in renal excret", "tokenized_content": [2, 14880, 3, 7495, 1927, 54, 17, 19428, 1982, 4374, 1956, 43, 3714, 1922, 2877, 1930, 3068, 14880, 16, 1925, 2760, 1922, 3068, 7964, 16, 1930, 1925, 2760, 1922, 4604, 9394, 3]}, "items": [{"id": "p_2181", "content": "Ammonia [SEP] A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolica", "score": 1, "type": null, "tokenized_content": [2, 14880, 3, 43, 29500, 10746, 4422, 18, 2176, 1977, 5333, 1922, 1920, 3362, 2409, 12942, 1927, 6805, 4751, 2409, 43, 3103, 2529, 1927, 4487, 1019, 3]}]}
{"query": {"id": "q_2182", "content": "dopamine [SEP] ith a decrease in blood and brain ammonia, an increase in brain dopamine, and an increase in renal excretion of ammonia and urea. Intrav", "tokenized_content": [2, 7964, 3, 24737, 43, 3714, 1922, 2877, 1930, 3068, 14880, 16, 1925, 2760, 1922, 3068, 7964, 16, 1930, 1925, 2760, 1922, 4604, 11093, 1927, 14880, 1930, 10505, 18, 6306, 3]}, "items": [{"id": "p_2182", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2183", "content": "urea [SEP] ain dopamine, and an increase in renal excretion of ammonia and urea. Intraventricular infusion of dopamine sufficient to raise the ", "tokenized_content": [2, 10505, 3, 9798, 1022, 7964, 16, 1930, 1925, 2760, 1922, 4604, 11093, 1927, 14880, 1930, 10505, 18, 29510, 7386, 1927, 7964, 5409, 1942, 13701, 1920, 3]}, "items": [{"id": "p_2183", "content": "Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote", "score": 1, "type": null, "tokenized_content": [2, 10505, 3, 43, 3547, 5333, 1922, 1920, 3568, 2037, 14880, 4152, 2007, 1920, 30097, 8547, 1943, 1927, 3835, 4576, 18, 2176, 1977, 1920, 7944, 2482, 4863, 1927, 2174, 3]}]}
{"query": {"id": "q_2184", "content": "encephalopathic [SEP] sonable explanation for the beneficial effects observed in some encephalopathic patients receiving L-dopa.", "tokenized_content": [2, 11591, 10982, 3, 9337, 2115, 8042, 1958, 1920, 6928, 2564, 2528, 1922, 2673, 11591, 10982, 2132, 5962, 54, 17, 19428, 18, 3]}, "items": [{"id": "p_2184", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2185", "content": "Heparin [SEP] Heparin-induced thrombocytopenia after liver transplantation.", "tokenized_content": [2, 9962, 3, 9962, 17, 2719, 17100, 2256, 3568, 6530, 18, 3]}, "items": [{"id": "p_2185", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_2186", "content": "thrombocytopenia [SEP] Heparin-induced thrombocytopenia after liver transplantation.", "tokenized_content": [2, 17100, 3, 9962, 17, 2719, 17100, 2256, 3568, 6530, 18, 3]}, "items": [{"id": "p_2186", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_2187", "content": "Unfractionated heparin sodium [SEP] BACKGROUND: Unfractionated heparin sodium (UFH) or low-molecular weight heparin (LMWH) is used in anticoa", "tokenized_content": [2, 6281, 27320, 1981, 9962, 5227, 3, 3872, 30, 6281, 27320, 1981, 9962, 5227, 12, 18661, 1023, 13, 2014, 2330, 17, 3272, 3388, 9962, 12, 28722, 1023, 13, 1977, 2251, 1922, 3]}, "items": [{"id": "p_2187", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_2188", "content": "UFH [SEP] BACKGROUND: Unfractionated heparin sodium (UFH) or low-molecular weight heparin (LMWH) is used in anticoagulan", "tokenized_content": [2, 18661, 1023, 3, 3872, 30, 6281, 27320, 1981, 9962, 5227, 12, 18661, 1023, 13, 2014, 2330, 17, 3272, 3388, 9962, 12, 28722, 1023, 13, 1977, 2251, 1922, 15496, 1928, 3]}, "items": [{"id": "p_2188", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_2189", "content": "low-molecular weight heparin [SEP] BACKGROUND: Unfractionated heparin sodium (UFH) or low-molecular weight heparin (LMWH) is used in anticoagulant protocols at several institutio", "tokenized_content": [2, 2330, 17, 3272, 3388, 9962, 3, 3872, 30, 6281, 27320, 1981, 9962, 5227, 12, 18661, 1023, 13, 2014, 2330, 17, 3272, 3388, 9962, 12, 28722, 1023, 13, 1977, 2251, 1922, 3]}, "items": [{"id": "p_2189", "content": "Heparin, Low-Molecular-Weight [SEP] Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective a", "score": 1, "type": null, "tokenized_content": [2, 9962, 16, 2330, 17, 3272, 17, 3388, 3, 9962, 6872, 1956, 43, 3272, 3388, 5394, 2192, 16055, 1930, 22348, 7546, 18, 2144, 2330, 17, 3272, 17, 3388, 6872, 2032, 3655, 43, 3]}]}
{"query": {"id": "q_2190", "content": "thrombosis [SEP] d in anticoagulant protocols at several institutions to prevent thrombosis after liver transplantation. Heparin-induced thrombocytopenia (", "tokenized_content": [2, 11354, 3, 46, 1922, 18509, 6997, 2019, 2980, 10977, 1942, 4625, 11354, 2256, 3568, 6530, 18, 9962, 17, 2719, 17100, 12, 3]}, "items": [{"id": "p_2190", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_2191", "content": "Heparin [SEP] institutions to prevent thrombosis after liver transplantation. Heparin-induced thrombocytopenia (HIT) is an adverse immune-mediated re", "tokenized_content": [2, 9962, 3, 10977, 1942, 4625, 11354, 2256, 3568, 6530, 18, 9962, 17, 2719, 17100, 12, 11314, 13, 1977, 1925, 5246, 3743, 17, 3434, 1964, 3]}, "items": [{"id": "p_2191", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_2192", "content": "thrombocytopenia [SEP] prevent thrombosis after liver transplantation. Heparin-induced thrombocytopenia (HIT) is an adverse immune-mediated reaction to heparin, result", "tokenized_content": [2, 17100, 3, 4625, 11354, 2256, 3568, 6530, 18, 9962, 17, 2719, 17100, 12, 11314, 13, 1977, 1925, 5246, 3743, 17, 3434, 3227, 1942, 9962, 16, 3211, 3]}, "items": [{"id": "p_2192", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_2193", "content": "HIT [SEP]  after liver transplantation. Heparin-induced thrombocytopenia (HIT) is an adverse immune-mediated reaction to heparin, resulting i", "tokenized_content": [2, 11314, 3, 2256, 3568, 6530, 18, 9962, 17, 2719, 17100, 12, 11314, 13, 1977, 1925, 5246, 3743, 17, 3434, 3227, 1942, 9962, 16, 3864, 51, 3]}, "items": [{"id": "p_2193", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_2194", "content": "heparin [SEP] BACKGROUND: Unfractionated heparin sodium (UFH) or low-molecular weight heparin (LMWH) is used in ", "tokenized_content": [2, 9962, 3, 3872, 30, 6281, 27320, 1981, 9962, 5227, 12, 18661, 1023, 13, 2014, 2330, 17, 3272, 3388, 9962, 12, 28722, 1023, 13, 1977, 2251, 1922, 3]}, "items": [{"id": "p_2194", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_2195", "content": "platelet aggregation [SEP] D 7 to 33 x 10(9)/L on POD 9, respectively. The heparin-induced platelet aggregation test was negative in these patients. The percentage of HIT anti", "tokenized_content": [2, 7163, 7883, 3, 46, 27, 1942, 3401, 66, 2119, 12, 29, 13, 19, 54, 1990, 10181, 29, 16, 2763, 18, 1920, 9962, 17, 2719, 7163, 7883, 2648, 1982, 3136, 1922, 3]}, "items": [{"id": "p_2195", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_2196", "content": "PTU [SEP] PTU-associated vasculitis in a girl with Turner Syndrome and Graves", "tokenized_content": [2, 4401, 1032, 3, 4401, 1032, 17, 2458, 21548, 1922, 43, 21676, 1956, 24826, 4741, 1930, 30066, 3]}, "items": [{"id": "p_2196", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_2197", "content": "vasculitis [SEP] PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.", "tokenized_content": [2, 21548, 3, 4401, 1032, 17, 2458, 21548, 1922, 43, 21676, 1956, 24826, 4741, 1930, 30066, 11, 2573, 18, 3]}, "items": [{"id": "p_2197", "content": "Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.\n   ", "score": 1, "type": null, "tokenized_content": [2, 21548, 3, 4531, 1927, 2967, 2340, 1927, 1920, 2877, 7208, 16, 2710, 1920, 9345, 31, 14785, 31, 1930, 6172, 1927, 1920, 13040, 2433, 1922, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_2198", "content": "Turner Syndrome [SEP] PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.", "tokenized_content": [2, 24826, 4741, 3, 4401, 1032, 17, 2458, 21548, 1922, 43, 21676, 1956, 24826, 4741, 1930, 30066, 11, 2573, 18, 3]}, "items": [{"id": "p_2198", "content": "Turner Syndrome [SEP] A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients genera", "score": 1, "type": null, "tokenized_content": [2, 24826, 4741, 3, 43, 4741, 1927, 9785, 21282, 2740, 1922, 8189, 5027, 2458, 1956, 1920, 21954, 3607, 16, 66, 12, 2014, 3607, 16, 66, 1037, 13, 18, 2132, 12774, 3]}]}
{"query": {"id": "q_2199", "content": "Graves' disease [SEP] PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.", "tokenized_content": [2, 30066, 11, 2573, 3, 4401, 1032, 17, 2458, 21548, 1922, 43, 21676, 1956, 24826, 4741, 1930, 30066, 11, 2573, 18, 3]}, "items": [{"id": "p_2199", "content": "Graves Disease [SEP] A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies again", "score": 1, "type": null, "tokenized_content": [2, 30066, 2573, 3, 43, 3059, 2386, 1927, 28413, 1956, 43, 9435, 28733, 3611, 2997, 18, 2176, 1977, 1925, 8904, 4770, 1988, 9300, 3788, 3116, 3]}]}
{"query": {"id": "q_2200", "content": "purpura [SEP] Palpable purpura is a concerning clinical finding in pediatric patients and can ", "tokenized_content": [2, 25945, 9280, 3, 24845, 25945, 9280, 1977, 43, 8679, 2535, 2849, 1922, 7460, 2132, 1930, 2112, 3]}, "items": [{"id": "p_2200", "content": "Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 3, 25945, 2951, 2014, 8084, 2471, 2312, 2863, 18778, 1943, 16, 7278, 7816, 2596, 1920, 14512, 16, 4189, 2007, 10489, 2460, 1920, 3878, 18, 2469, 1920, 5998, 3]}]}
{"query": {"id": "q_2201", "content": "vasculitis [SEP] infectious and autoimmune processes. A rare cause, drug-induced vasculitis, may result from the production of antineutrophil cytoplasmic a", "tokenized_content": [2, 21548, 3, 7465, 1930, 8904, 4028, 18, 43, 5844, 3936, 16, 2838, 17, 2719, 21548, 16, 2278, 3211, 2037, 1920, 3372, 1927, 29128, 4092, 4748, 6823, 43, 3]}, "items": [{"id": "p_2201", "content": "Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.\n   ", "score": 1, "type": null, "tokenized_content": [2, 21548, 3, 4531, 1927, 2967, 2340, 1927, 1920, 2877, 7208, 16, 2710, 1920, 9345, 31, 14785, 31, 1930, 6172, 1927, 1920, 13040, 2433, 1922, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_2202", "content": "Turner syndrome [SEP] dies (ANCAs) in response to a medication. We report a girl with Turner syndrome and Graves' disease who presented with palpable purpuric lesion", "tokenized_content": [2, 24826, 4741, 3, 21354, 12, 28573, 1036, 13, 1922, 2644, 1942, 43, 6093, 18, 2038, 3809, 43, 21676, 1956, 24826, 4741, 1930, 30066, 11, 2573, 2746, 3549, 1956, 24845, 25945, 3]}, "items": [{"id": "p_2202", "content": "Turner Syndrome [SEP] A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients genera", "score": 1, "type": null, "tokenized_content": [2, 24826, 4741, 3, 43, 4741, 1927, 9785, 21282, 2740, 1922, 8189, 5027, 2458, 1956, 1920, 21954, 3607, 16, 66, 12, 2014, 3607, 16, 66, 1037, 13, 18, 2132, 12774, 3]}]}
{"query": {"id": "q_2203", "content": "Graves' disease [SEP] onse to a medication. We report a girl with Turner syndrome and Graves' disease who presented with palpable purpuric lesions. The diagnosis of ", "tokenized_content": [2, 30066, 11, 2573, 3, 24335, 1021, 1942, 43, 6093, 18, 2038, 3809, 43, 21676, 1956, 24826, 4741, 1930, 30066, 11, 2573, 2746, 3549, 1956, 24845, 25945, 15861, 4518, 18, 1920, 3]}, "items": [{"id": "p_2203", "content": "Graves Disease [SEP] A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies again", "score": 1, "type": null, "tokenized_content": [2, 30066, 2573, 3, 43, 3059, 2386, 1927, 28413, 1956, 43, 9435, 28733, 3611, 2997, 18, 2176, 1977, 1925, 8904, 4770, 1988, 9300, 3788, 3116, 3]}]}
{"query": {"id": "q_2204", "content": "purpuric lesions [SEP] Turner syndrome and Graves' disease who presented with palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis ", "tokenized_content": [2, 25945, 15861, 4518, 3, 24826, 4741, 1930, 30066, 11, 2573, 2746, 3549, 1956, 24845, 25945, 15861, 4518, 18, 1920, 3574, 1927, 20299, 22523, 20122, 12, 4401, 1032, 13, 17, 2458, 3]}, "items": [{"id": "p_2204", "content": "Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 3, 25945, 2951, 2014, 8084, 2471, 2312, 2863, 18778, 1943, 16, 7278, 7816, 2596, 1920, 14512, 16, 4189, 2007, 10489, 2460, 1920, 3878, 18, 2469, 1920, 5998, 3]}]}
{"query": {"id": "q_2205", "content": "propylthiouracil [SEP]  who presented with palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis was made by observation of consiste", "tokenized_content": [2, 20299, 22523, 20122, 3, 2746, 3549, 1956, 24845, 25945, 15861, 4518, 18, 1920, 3574, 1927, 20299, 22523, 20122, 12, 4401, 1032, 13, 17, 2458, 21548, 1982, 3915, 2007, 5275, 1927, 3]}, "items": [{"id": "p_2205", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_2206", "content": "PTU [SEP] h palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis was made by observation of consistent cl", "tokenized_content": [2, 4401, 1032, 3, 50, 24845, 25945, 15861, 4518, 18, 1920, 3574, 1927, 20299, 22523, 20122, 12, 4401, 1032, 13, 17, 2458, 21548, 1982, 3915, 2007, 5275, 1927, 3499, 2111, 3]}, "items": [{"id": "p_2206", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_2207", "content": "hyperthyroidism [SEP] following withdrawal of PTU. Subsequent treatment of persistent hyperthyroidism with radioablation did not result in an exacerbation of the vas", "tokenized_content": [2, 28413, 3, 2894, 9594, 1927, 4401, 1032, 18, 4521, 2311, 1927, 7733, 28413, 1956, 8466, 18613, 1943, 2811, 2084, 3211, 1922, 1925, 17021, 1927, 1920, 6350, 3]}, "items": [{"id": "p_2207", "content": "Hyperthyroidism [SEP] Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28413, 3, 10694, 1940, 10411, 2001, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 18, 4664, 2428, 1927, 6918, 10224, 2760, 5342, 4487, 2769, 18, 3]}]}
{"query": {"id": "q_2208", "content": "Succinylcholine [SEP] Succinylcholine-induced masseter muscle rigidity during bronchoscopic removal o", "tokenized_content": [2, 13791, 2199, 11603, 3, 13791, 2199, 11603, 17, 2719, 3411, 2732, 3760, 20471, 2409, 7777, 15092, 6025, 57, 3]}, "items": [{"id": "p_2208", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2209", "content": "masseter muscle rigidity [SEP] Succinylcholine-induced masseter muscle rigidity during bronchoscopic removal of a tracheal foreign body.", "tokenized_content": [2, 3411, 2732, 3760, 20471, 3, 13791, 2199, 11603, 17, 2719, 3411, 2732, 3760, 20471, 2409, 7777, 15092, 6025, 1927, 43, 16810, 12400, 3362, 18, 3]}, "items": [{"id": "p_2209", "content": "Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc", "score": 1, "type": null, "tokenized_content": [2, 6349, 23084, 3, 24431, 12486, 8332, 1927, 1920, 3411, 2732, 3760, 3864, 1922, 5495, 2903, 16795, 10408, 18, 2052, 2278, 1998, 3945, 1956, 43, 5386, 1927, 3902, 16, 2043, 3]}]}
{"query": {"id": "q_2210", "content": "Masseter muscle rigidity [SEP] Masseter muscle rigidity during general anesthesia is considered an early warning sign o", "tokenized_content": [2, 3411, 2732, 3760, 20471, 3, 3411, 2732, 3760, 20471, 2409, 3335, 8871, 1977, 3311, 1925, 3120, 18149, 2105, 57, 3]}, "items": [{"id": "p_2210", "content": "Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc", "score": 1, "type": null, "tokenized_content": [2, 6349, 23084, 3, 24431, 12486, 8332, 1927, 1920, 3411, 2732, 3760, 3864, 1922, 5495, 2903, 16795, 10408, 18, 2052, 2278, 1998, 3945, 1956, 43, 5386, 1927, 3902, 16, 2043, 3]}]}
{"query": {"id": "q_2211", "content": "malignant hyperthermia [SEP] ia is considered an early warning sign of a possible episode of malignant hyperthermia. The decision whether to continue or discontinue the procedure ", "tokenized_content": [2, 6558, 21945, 3, 11640, 1977, 3311, 1925, 3120, 18149, 2105, 1927, 43, 3216, 11631, 1927, 6558, 21945, 18, 1920, 5534, 3053, 1942, 9085, 2014, 9035, 2182, 1920, 4360, 3]}, "items": [{"id": "p_2211", "content": "Malignant Hyperthermia [SEP] Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6558, 21945, 3, 4052, 1930, 9122, 7164, 1927, 3449, 7936, 2007, 12330, 20471, 2894, 3335, 8871, 18, 3]}]}
{"query": {"id": "q_2212", "content": "masseter muscle rigidity [SEP] procedure depends on the urgency of the surgery and severity of masseter muscle rigidity. Here, we describe a case of severe masseter muscle rigidity (j", "tokenized_content": [2, 3411, 2732, 3760, 20471, 3, 4360, 7315, 1990, 1920, 24414, 1927, 1920, 3782, 1930, 5155, 1927, 3411, 2732, 3760, 20471, 18, 3410, 16, 2038, 5993, 43, 3087, 1927, 4010, 3411, 3]}, "items": [{"id": "p_2212", "content": "Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc", "score": 1, "type": null, "tokenized_content": [2, 6349, 23084, 3, 24431, 12486, 8332, 1927, 1920, 3411, 2732, 3760, 3864, 1922, 5495, 2903, 16795, 10408, 18, 2052, 2278, 1998, 3945, 1956, 43, 5386, 1927, 3902, 16, 2043, 3]}]}
{"query": {"id": "q_2213", "content": "jaw of steel [SEP] y. Here, we describe a case of severe masseter muscle rigidity (jaw of steel) after succinylcholine (Sch) administration during general anes", "tokenized_content": [2, 16795, 1927, 14485, 3, 67, 18, 3410, 16, 2038, 5993, 43, 3087, 1927, 4010, 3411, 2732, 3760, 20471, 12, 16795, 1927, 14485, 13, 2256, 13791, 2199, 11603, 12, 2966, 13, 3]}, "items": [{"id": "p_2213", "content": "Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc", "score": 1, "type": null, "tokenized_content": [2, 6349, 23084, 3, 24431, 12486, 8332, 1927, 1920, 3411, 2732, 3760, 3864, 1922, 5495, 2903, 16795, 10408, 18, 2052, 2278, 1998, 3945, 1956, 43, 5386, 1927, 3902, 16, 2043, 3]}]}
{"query": {"id": "q_2214", "content": "succinylcholine [SEP]  a case of severe masseter muscle rigidity (jaw of steel) after succinylcholine (Sch) administration during general anesthetic management for r", "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 3087, 1927, 4010, 3411, 2732, 3760, 20471, 12, 16795, 1927, 14485, 13, 2256, 13791, 2199, 11603, 12, 2966, 13, 4183, 2409, 3335, 16111, 4280, 1958, 3]}, "items": [{"id": "p_2214", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2215", "content": "Sch [SEP]  masseter muscle rigidity (jaw of steel) after succinylcholine (Sch) administration during general anesthetic management for rigid ", "tokenized_content": [2, 2966, 3, 3411, 2732, 3760, 20471, 12, 16795, 1927, 14485, 13, 2256, 13791, 2199, 11603, 12, 2966, 13, 4183, 2409, 3335, 16111, 4280, 1958, 12383, 3]}, "items": [{"id": "p_2215", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2216", "content": "propofol [SEP] acheal foreign body. Anesthesia was continued uneventfully with propofol infusion while all facilities were available to detect and trea", "tokenized_content": [2, 16615, 3, 18564, 1923, 12400, 3362, 18, 8871, 1982, 7583, 29641, 1954, 1956, 16615, 7386, 2679, 2136, 8774, 1985, 3322, 1942, 4277, 1930, 2171, 1019, 3]}, "items": [{"id": "p_2216", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_2217", "content": "neurological dysfunction [SEP] Minor neurological dysfunction, cognitive development, and somatic development at the age of 3", "tokenized_content": [2, 7605, 5273, 3, 5857, 7605, 5273, 16, 4328, 2740, 16, 1930, 8548, 2740, 2019, 1920, 2632, 1927, 23, 3]}, "items": [{"id": "p_2217", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2218", "content": "dexamethasone [SEP] pment, and somatic development at the age of 3 to 7 years after dexamethasone treatment in very-low birth-weight infants.", "tokenized_content": [2, 12681, 3, 27685, 4905, 16, 1930, 8548, 2740, 2019, 1920, 2632, 1927, 23, 1942, 27, 2739, 2256, 12681, 2311, 1922, 3345, 17, 2330, 5043, 17, 3388, 5969, 18, 3]}, "items": [{"id": "p_2218", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2219", "content": "neurological dysfunction [SEP] The objective of this study was to assess minor neurological dysfunction, cognitive development, and somatic development after dexametha", "tokenized_content": [2, 7605, 5273, 3, 1920, 4470, 1927, 2052, 2161, 1982, 1942, 2634, 5857, 7605, 5273, 16, 4328, 2740, 16, 1930, 8548, 2740, 2256, 7473, 10758, 1019, 3]}, "items": [{"id": "p_2219", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2220", "content": "dexamethasone [SEP] sfunction, cognitive development, and somatic development after dexamethasone therapy in very-low-birthweight infants. Thirty-three children ", "tokenized_content": [2, 12681, 3, 6347, 3922, 16, 4328, 2740, 16, 1930, 8548, 2740, 2256, 12681, 3181, 1922, 3345, 17, 2330, 17, 25380, 5969, 18, 9942, 17, 2559, 3069, 3]}, "items": [{"id": "p_2220", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2221", "content": "Dexamethasone [SEP] ethasone treatment. Data were assessed at the age of 3-7 years. Dexamethasone was started between the 7th and the 28th day of life over 7 day", "tokenized_content": [2, 12681, 3, 3293, 11718, 2311, 18, 2230, 1985, 3683, 2019, 1920, 2632, 1927, 23, 17, 27, 2739, 18, 12681, 1982, 8074, 2192, 1920, 23146, 1930, 1920, 3158, 1963, 3007, 1927, 3]}, "items": [{"id": "p_2221", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2222", "content": "asphyxia [SEP] ys with a total dose of 2.35 mg/kg/day. Exclusion criteria were asphyxia, malformations, major surgical interventions, small for gestati", "tokenized_content": [2, 28492, 2126, 3, 24018, 1956, 43, 2698, 3253, 1927, 22, 18, 3259, 2786, 19, 3621, 19, 3007, 18, 7901, 4164, 1985, 28492, 2126, 16, 17360, 16, 3044, 4548, 4984, 16, 3]}, "items": [{"id": "p_2222", "content": "Asphyxia [SEP] A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28492, 2126, 3, 43, 6598, 2625, 4189, 2007, 3630, 1927, 4612, 16, 16687, 1922, 2754, 4792, 2014, 7432, 10975, 1927, 3308, 18, 3]}]}
{"query": {"id": "q_2223", "content": "malformations [SEP] total dose of 2.35 mg/kg/day. Exclusion criteria were asphyxia, malformations, major surgical interventions, small for gestational age, intra", "tokenized_content": [2, 17360, 3, 2698, 3253, 1927, 22, 18, 3259, 2786, 19, 3621, 19, 3007, 18, 7901, 4164, 1985, 28492, 2126, 16, 17360, 16, 3044, 4548, 4984, 16, 2858, 1958, 10000, 2632, 3]}, "items": [{"id": "p_2223", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_2224", "content": "haemorrhage [SEP] ical interventions, small for gestational age, intraventricular haemorrhage grades III and IV, periventricular leukomalacia, and severe psy", "tokenized_content": [2, 23352, 3, 14784, 1024, 4984, 16, 2858, 1958, 10000, 2632, 16, 29510, 23352, 13658, 4337, 1930, 4370, 16, 16505, 11817, 5104, 4229, 20243, 16, 1930, 4010, 2742, 1012, 3]}, "items": [{"id": "p_2224", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2225", "content": "periventricular leukomalacia [SEP] estational age, intraventricular haemorrhage grades III and IV, periventricular leukomalacia, and severe psychomotor retardation. Each child was examined by", "tokenized_content": [2, 16505, 11817, 5104, 4229, 20243, 3, 3255, 2676, 2632, 16, 29510, 23352, 13658, 4337, 1930, 4370, 16, 16505, 11817, 5104, 4229, 20243, 16, 1930, 4010, 26261, 16342, 18, 2362, 2748, 3]}, "items": [{"id": "p_2225", "content": "Leukomalacia, Periventricular [SEP] Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The c", "score": 1, "type": null, "tokenized_content": [2, 5104, 4229, 20243, 16, 16505, 11817, 3, 9174, 1927, 4511, 6537, 6811, 1942, 1920, 6329, 21008, 2894, 6329, 7264, 2014, 3068, 7716, 1922, 13250, 18, 1920, 45, 3]}]}
{"query": {"id": "q_2226", "content": "psychomotor retardation [SEP] age grades III and IV, periventricular leukomalacia, and severe psychomotor retardation. Each child was examined by a neuropediatrician for minor neuro", "tokenized_content": [2, 26261, 16342, 3, 2632, 13658, 4337, 1930, 4370, 16, 16505, 11817, 5104, 4229, 20243, 16, 1930, 4010, 26261, 16342, 18, 2362, 2748, 1982, 3572, 2007, 43, 13889, 19258, 3319, 3122, 3]}, "items": [{"id": "p_2226", "content": "Psychomotor Disorders [SEP] Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26261, 4414, 3, 6754, 1927, 4842, 2347, 1988, 2032, 2458, 1956, 6805, 1930, 2447, 17, 6805, 4328, 4414, 18, 3]}]}
{"query": {"id": "q_2227", "content": "neurological dysfunctions [SEP] ation. Each child was examined by a neuropediatrician for minor neurological dysfunctions and tested by a psychologist for cognitive development with a K", "tokenized_content": [2, 7605, 24199, 3, 2019, 2001, 18, 2362, 2748, 1982, 3572, 2007, 43, 13889, 19258, 3319, 3122, 1958, 5857, 7605, 24199, 1930, 3620, 2007, 43, 30228, 1958, 4328, 2740, 1956, 43, 3]}, "items": [{"id": "p_2227", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2228", "content": "levodopa [SEP] Force overflow and levodopa-induced dyskinesias in Parkinson's disease.", "tokenized_content": [2, 26723, 3, 5495, 2338, 9893, 1930, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2228", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2229", "content": "dyskinesias [SEP] Force overflow and levodopa-induced dyskinesias in Parkinson's disease.", "tokenized_content": [2, 3890, 26682, 1036, 3, 5495, 2338, 9893, 1930, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2229", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2230", "content": "Parkinson's disease [SEP] Force overflow and levodopa-induced dyskinesias in Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 5495, 2338, 9893, 1930, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2230", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2231", "content": "Parkinson's disease [SEP] We assessed force coordination of the hand in Parkinson's disease and its relationship to motor complications of levodopa therapy", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2038, 3683, 5495, 9478, 1927, 1920, 3897, 1922, 10124, 11, 61, 2573, 1930, 2496, 3303, 1942, 4842, 5021, 1927, 26723, 3181, 3]}, "items": [{"id": "p_2231", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2232", "content": "levodopa [SEP] kinson's disease and its relationship to motor complications of levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We", "tokenized_content": [2, 26723, 3, 30082, 1916, 11, 61, 2573, 1930, 2496, 3303, 1942, 4842, 5021, 1927, 26723, 3181, 16, 4443, 1942, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 3]}, "items": [{"id": "p_2232", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2233", "content": "dyskinesias [SEP] lications of levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We studied two groups of Parkinson's disease patients wi", "tokenized_content": [2, 3890, 26682, 1036, 3, 10247, 2082, 1927, 26723, 3181, 16, 4443, 1942, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 3942, 2288, 2671, 1927, 10124, 11, 61, 3]}, "items": [{"id": "p_2233", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2234", "content": "LID [SEP] levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We studied two groups of Parkinson's disease patients with (P", "tokenized_content": [2, 13096, 3, 26723, 3181, 16, 4443, 1942, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 3942, 2288, 2671, 1927, 10124, 11, 61, 2573, 2132, 1956, 12, 58, 3]}, "items": [{"id": "p_2234", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2235", "content": "Parkinson's Disease [SEP] nd age-matched healthy controls. The motor score of the Unified Parkinson's Disease Rating Scale, a dyskinesia score and force in a grip-lift parad", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 8026, 2632, 17, 5992, 4097, 3562, 18, 1920, 4842, 3593, 1927, 1920, 21281, 10124, 11, 61, 2573, 7276, 3536, 16, 43, 3890, 26682, 3593, 1930, 3]}, "items": [{"id": "p_2235", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2236", "content": "dyskinesia [SEP] lications of levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We studied two groups of Parkinson's disease patients w", "tokenized_content": [2, 3890, 26682, 3, 10247, 2082, 1927, 26723, 3181, 16, 4443, 1942, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 13, 18, 2038, 3942, 2288, 2671, 1927, 10124, 11, 61, 2573, 3]}, "items": [{"id": "p_2236", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2237", "content": "ventricular septal defect [SEP] Postinfarction ventricular septal defect associated with long-term steroid therapy.", "tokenized_content": [2, 6493, 16458, 7374, 3, 15633, 29120, 2236, 6493, 16458, 7374, 2458, 1956, 2815, 17, 2576, 9507, 3181, 18, 3]}, "items": [{"id": "p_2237", "content": "Ventricular Septal Rupture [SEP] Laceration or tearing of the VENTRICULAR SEPTUM, usually caused by MYOCARDIAL INFARCTION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 16458, 12460, 3, 7511, 5026, 2014, 12650, 1941, 1927, 1920, 6493, 17026, 16, 5394, 4189, 2007, 6497, 8358, 18, 3]}]}
{"query": {"id": "q_2238", "content": "steroid [SEP] tinfarction ventricular septal defect associated with long-term steroid therapy.", "tokenized_content": [2, 9507, 3, 12347, 29120, 2236, 6493, 16458, 7374, 2458, 1956, 2815, 17, 2576, 9507, 3181, 18, 3]}, "items": [{"id": "p_2238", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_2239", "content": "ventricular septal rupture [SEP] Two cases of postinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the ", "tokenized_content": [2, 6493, 16458, 12460, 3, 2288, 2919, 1927, 15633, 29120, 2236, 6493, 16458, 12460, 1922, 2132, 1990, 2815, 17, 2576, 9507, 3181, 2032, 3549, 1930, 1920, 3]}, "items": [{"id": "p_2239", "content": "Ventricular Septal Rupture [SEP] Laceration or tearing of the VENTRICULAR SEPTUM, usually caused by MYOCARDIAL INFARCTION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 16458, 12460, 3, 7511, 5026, 2014, 12650, 1941, 1927, 1920, 6493, 17026, 16, 5394, 4189, 2007, 6497, 8358, 18, 3]}]}
{"query": {"id": "q_2240", "content": "steroid [SEP] tinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the favourable outcome in both cases ", "tokenized_content": [2, 9507, 3, 12347, 29120, 2236, 6493, 16458, 12460, 1922, 2132, 1990, 2815, 17, 2576, 9507, 3181, 2032, 3549, 1930, 1920, 18845, 3924, 1922, 2321, 2919, 3]}, "items": [{"id": "p_2240", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_2241", "content": "septal rupture [SEP] Two cases of postinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the ", "tokenized_content": [2, 16458, 12460, 3, 2288, 2919, 1927, 15633, 29120, 2236, 6493, 16458, 12460, 1922, 2132, 1990, 2815, 17, 2576, 9507, 3181, 2032, 3549, 1930, 1920, 3]}, "items": [{"id": "p_2241", "content": "Ventricular Septal Rupture [SEP] Laceration or tearing of the VENTRICULAR SEPTUM, usually caused by MYOCARDIAL INFARCTION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 16458, 12460, 3, 7511, 5026, 2014, 12650, 1941, 1927, 1920, 6493, 17026, 16, 5394, 4189, 2007, 6497, 8358, 18, 3]}]}
{"query": {"id": "q_2242", "content": "Angioedema [SEP] Angioedema associated with droperidol administration.", "tokenized_content": [2, 29220, 16670, 3, 29220, 16670, 2458, 1956, 7086, 18842, 22389, 1024, 4183, 18, 3]}, "items": [{"id": "p_2242", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2243", "content": "droperidol [SEP] Angioedema associated with droperidol administration.", "tokenized_content": [2, 7086, 18842, 22389, 1024, 3, 29220, 16670, 2458, 1956, 7086, 18842, 22389, 1024, 4183, 18, 3]}, "items": [{"id": "p_2243", "content": "Droperidol [SEP] A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such", "score": 1, "type": null, "tokenized_content": [2, 7086, 18842, 22389, 1024, 3, 43, 2308, 5134, 17616, 2290, 1956, 3335, 3879, 2551, 1942, 2690, 1927, 25107, 18, 2176, 1977, 2251, 1922, 11799, 1956, 1925, 9384, 14501, 2427, 3]}]}
{"query": {"id": "q_2244", "content": "Angioedema [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a w", "tokenized_content": [2, 29220, 16670, 3, 29220, 16670, 16, 2222, 3171, 1966, 29220, 2912, 18916, 2002, 10144, 2014, 9012, 12940, 1021, 11, 61, 2573, 16, 1977, 43, 65, 3]}, "items": [{"id": "p_2244", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2245", "content": "angioneurotic edema [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a well-demarcated, localized edema inv", "tokenized_content": [2, 29220, 2912, 18916, 2002, 10144, 3, 29220, 16670, 16, 2222, 3171, 1966, 29220, 2912, 18916, 2002, 10144, 2014, 9012, 12940, 1021, 11, 61, 2573, 16, 1977, 43, 2486, 17, 25702, 3]}, "items": [{"id": "p_2245", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2246", "content": "Quincke's disease [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a well-demarcated, localized edema involving the subcutaneo", "tokenized_content": [2, 9012, 12940, 1021, 11, 61, 2573, 3, 29220, 16670, 16, 2222, 3171, 1966, 29220, 2912, 18916, 2002, 10144, 2014, 9012, 12940, 1021, 11, 61, 2573, 16, 1977, 43, 2486, 17, 3]}, "items": [{"id": "p_2246", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2247", "content": "edema [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a w", "tokenized_content": [2, 10144, 3, 29220, 16670, 16, 2222, 3171, 1966, 29220, 2912, 18916, 2002, 10144, 2014, 9012, 12940, 1021, 11, 61, 2573, 16, 1977, 43, 65, 3]}, "items": [{"id": "p_2247", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2248", "content": "upper-airway obstruction [SEP] calized edema involving the subcutaneous tissues that may cause upper-airway obstruction. We report the case of a previously healthy 19-year-old man wit", "tokenized_content": [2, 5199, 17, 8155, 10849, 3, 2570, 2301, 10144, 5884, 1920, 8634, 3878, 1988, 2278, 3936, 5199, 17, 8155, 10849, 18, 2038, 3809, 1920, 3087, 1927, 43, 3024, 4097, 2282, 17, 3]}, "items": [{"id": "p_2248", "content": "Airway Obstruction [SEP] Any hindrance to the passage of air into and out of the lungs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8155, 10849, 3, 2967, 28831, 1942, 1920, 11008, 1927, 4433, 2460, 1930, 2397, 1927, 1920, 9193, 18, 3]}]}
{"query": {"id": "q_2249", "content": "drug allergies [SEP]  the case of a previously healthy 19-year-old man with no known drug allergies in whom angioedema with significant tongue swelling and protrus", "tokenized_content": [2, 2838, 26722, 3, 1920, 3087, 1927, 43, 3024, 4097, 2282, 17, 2476, 17, 4156, 2323, 1956, 2239, 3171, 2838, 26722, 1922, 8566, 29220, 16670, 1956, 2228, 14761, 11438, 1930, 12251, 3]}, "items": [{"id": "p_2249", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_2250", "content": "angioedema [SEP] ly healthy 19-year-old man with no known drug allergies in whom angioedema with significant tongue swelling and protrusion developed withi", "tokenized_content": [2, 29220, 16670, 3, 7518, 4097, 2282, 17, 2476, 17, 4156, 2323, 1956, 2239, 3171, 2838, 26722, 1922, 8566, 29220, 16670, 1956, 2228, 14761, 11438, 1930, 24384, 3530, 1956, 1033, 3]}, "items": [{"id": "p_2250", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2251", "content": "tongue swelling [SEP] ith no known drug allergies in whom angioedema with significant tongue swelling and protrusion developed within 10 minutes of the administratio", "tokenized_content": [2, 14761, 11438, 3, 24737, 2239, 3171, 2838, 26722, 1922, 8566, 29220, 16670, 1956, 2228, 14761, 11438, 1930, 24384, 3530, 2651, 2119, 4814, 1927, 1920, 10473, 1968, 1037, 3]}, "items": [{"id": "p_2251", "content": "Tongue Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14761, 3902, 3, 3]}]}
{"query": {"id": "q_2252", "content": "swelling [SEP] known drug allergies in whom angioedema with significant tongue swelling and protrusion developed within 10 minutes of the administratio", "tokenized_content": [2, 11438, 3, 3171, 2838, 26722, 1922, 8566, 29220, 16670, 1956, 2228, 14761, 11438, 1930, 24384, 3530, 2651, 2119, 4814, 1927, 1920, 10473, 1968, 1037, 3]}, "items": [{"id": "p_2252", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2253", "content": "droperidol [SEP]  within 10 minutes of the administration of a single IV dose of droperidol.", "tokenized_content": [2, 7086, 18842, 22389, 1024, 3, 2651, 2119, 4814, 1927, 1920, 4183, 1927, 43, 2957, 4370, 3253, 1927, 7086, 18842, 22389, 1024, 18, 3]}, "items": [{"id": "p_2253", "content": "Droperidol [SEP] A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such", "score": 1, "type": null, "tokenized_content": [2, 7086, 18842, 22389, 1024, 3, 43, 2308, 5134, 17616, 2290, 1956, 3335, 3879, 2551, 1942, 2690, 1927, 25107, 18, 2176, 1977, 2251, 1922, 11799, 1956, 1925, 9384, 14501, 2427, 3]}]}
{"query": {"id": "q_2254", "content": "Clarithromycin [SEP] Clarithromycin-associated visual hallucinations in a patient with chronic rena", "tokenized_content": [2, 6932, 20402, 3, 6932, 20402, 17, 2458, 3737, 27013, 1922, 43, 2774, 1956, 3724, 3866, 1019, 3]}, "items": [{"id": "p_2254", "content": "Clarithromycin [SEP] A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibi", "score": 1, "type": null, "tokenized_content": [2, 6932, 20402, 3, 43, 8762, 18801, 4905, 4116, 2002, 23929, 2261, 7267, 3595, 2037, 22925, 1988, 1977, 3500, 3316, 43, 5386, 1927, 11679, 18, 2176, 2112, 2439, 1033, 3]}]}
{"query": {"id": "q_2255", "content": "visual hallucinations [SEP] Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulator", "tokenized_content": [2, 3737, 27013, 3, 6932, 20402, 17, 2458, 3737, 27013, 1922, 43, 2774, 1956, 3724, 4604, 4574, 1990, 4798, 26236, 3061, 3]}, "items": [{"id": "p_2255", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2256", "content": "chronic renal failure [SEP] arithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis.", "tokenized_content": [2, 3724, 4604, 4574, 3, 22259, 11265, 17, 2458, 3737, 27013, 1922, 43, 2774, 1956, 3724, 4604, 4574, 1990, 4798, 15280, 10706, 9787, 18, 3]}, "items": [{"id": "p_2256", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_2257", "content": "Visual hallucinations [SEP] Visual hallucinations are a rare event in chronic renal failure and not related to ur", "tokenized_content": [2, 3737, 27013, 3, 3737, 27013, 2032, 43, 5844, 4817, 1922, 3724, 4604, 4574, 1930, 2084, 2712, 1942, 3674, 3]}, "items": [{"id": "p_2257", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2258", "content": "chronic renal failure [SEP] Visual hallucinations are a rare event in chronic renal failure and not related to uremia per se. Unreported in the literature ", "tokenized_content": [2, 3724, 4604, 4574, 3, 3737, 27013, 2032, 43, 5844, 4817, 1922, 3724, 4604, 4574, 1930, 2084, 2712, 1942, 6794, 6026, 2079, 2058, 18, 13497, 11568, 1922, 1920, 4431, 3]}, "items": [{"id": "p_2258", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_2259", "content": "uremia [SEP] ns are a rare event in chronic renal failure and not related to uremia per se. Unreported in the literature is visual hallucinations o", "tokenized_content": [2, 6794, 6026, 3, 4246, 2032, 43, 5844, 4817, 1922, 3724, 4604, 4574, 1930, 2084, 2712, 1942, 6794, 6026, 2079, 2058, 18, 13497, 11568, 1922, 1920, 4431, 1977, 3737, 27013, 57, 3]}, "items": [{"id": "p_2259", "content": "Uremia [SEP] A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the resul", "score": 1, "type": null, "tokenized_content": [2, 6794, 6026, 3, 43, 2535, 4741, 2458, 1956, 1920, 7521, 1927, 4604, 10437, 4461, 2014, 29870, 13599, 1922, 1920, 2877, 18, 2176, 1977, 5394, 1920, 2164, 3]}]}
{"query": {"id": "q_2260", "content": "visual hallucinations [SEP] d not related to uremia per se. Unreported in the literature is visual hallucinations occurring in association with the new macrolide antibiotic, cla", "tokenized_content": [2, 3737, 27013, 3, 46, 2084, 2712, 1942, 6794, 6026, 2079, 2058, 18, 13497, 11568, 1922, 1920, 4431, 1977, 3737, 27013, 6966, 1922, 3279, 1956, 1920, 2814, 23929, 2261, 7267, 16, 3]}, "items": [{"id": "p_2260", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2261", "content": "macrolide [SEP]  is visual hallucinations occurring in association with the new macrolide antibiotic, clarithromycin. We describe such a case in a patien", "tokenized_content": [2, 23929, 2261, 3, 1977, 3737, 27013, 6966, 1922, 3279, 1956, 1920, 2814, 23929, 2261, 7267, 16, 6932, 20402, 18, 2038, 5993, 2427, 43, 3087, 1922, 43, 2091, 1917, 3]}, "items": [{"id": "p_2261", "content": "Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ", "score": 1, "type": null, "tokenized_content": [2, 23929, 3726, 3, 43, 2210, 1927, 3868, 17514, 21924, 13153, 4300, 5333, 2007, 4659, 7140, 1927, 3137, 24682, 1036, 3637, 2301, 2460, 43, 3103, 12, 2357, 3]}]}
{"query": {"id": "q_2262", "content": "clarithromycin [SEP] ons occurring in association with the new macrolide antibiotic, clarithromycin. We describe such a case in a patient with end-stage renal dise", "tokenized_content": [2, 6932, 20402, 3, 24335, 6966, 1922, 3279, 1956, 1920, 2814, 23929, 2261, 7267, 16, 6932, 20402, 18, 2038, 5993, 2427, 43, 3087, 1922, 43, 2774, 1956, 2482, 17, 3587, 4604, 3]}, "items": [{"id": "p_2262", "content": "Clarithromycin [SEP] A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibi", "score": 1, "type": null, "tokenized_content": [2, 6932, 20402, 3, 43, 8762, 18801, 4905, 4116, 2002, 23929, 2261, 7267, 3595, 2037, 22925, 1988, 1977, 3500, 3316, 43, 5386, 1927, 11679, 18, 2176, 2112, 2439, 1033, 3]}]}
{"query": {"id": "q_2263", "content": "end-stage renal disease [SEP] otic, clarithromycin. We describe such a case in a patient with end-stage renal disease (ESRD) maintained on continuous ambulatory peritoneal dialysis ", "tokenized_content": [2, 2482, 17, 3587, 4604, 2573, 3, 7608, 1935, 16, 6932, 20402, 18, 2038, 5993, 2427, 43, 3087, 1922, 43, 2774, 1956, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 5514, 3]}, "items": [{"id": "p_2263", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_2264", "content": "ESRD [SEP] describe such a case in a patient with end-stage renal disease (ESRD) maintained on continuous ambulatory peritoneal dialysis (CAPD)", "tokenized_content": [2, 17070, 3, 5993, 2427, 43, 3087, 1922, 43, 2774, 1956, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 5514, 1990, 4798, 15280, 10706, 9787, 12, 2853, 1007, 13, 3]}, "items": [{"id": "p_2264", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_2265", "content": "aluminum [SEP] nal failure in a functionally anephric patient, with underlying aluminum intoxication, may have facilitated the appearance of this neuro", "tokenized_content": [2, 16874, 3, 13120, 4574, 1922, 43, 9346, 9860, 2102, 3133, 2774, 16, 1956, 5030, 16874, 20965, 16, 2278, 2162, 11556, 1920, 7818, 1927, 2052, 3366, 3]}, "items": [{"id": "p_2265", "content": "Aluminum [SEP] A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16874, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 2529, 2590, 16, 11241, 17530, 1969, 16, 1930, 11241, 3388, 3179, 18, 5613, 18, 3]}]}
{"query": {"id": "q_2266", "content": "neurotoxic [SEP] minum intoxication, may have facilitated the appearance of this neurotoxic side effect. It is important to understand the pharmacokinetics", "tokenized_content": [2, 20919, 3, 2360, 1989, 20965, 16, 2278, 2162, 11556, 1920, 7818, 1927, 2052, 20919, 4159, 2495, 18, 2176, 1977, 2715, 1942, 5734, 1920, 14927, 3]}, "items": [{"id": "p_2266", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2267", "content": "renal toxicity [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.", "tokenized_content": [2, 4604, 5532, 3, 3939, 4604, 5532, 1927, 12377, 12, 25622, 7898, 13, 17, 7630, 26898, 19627, 6897, 18, 3]}, "items": [{"id": "p_2267", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2268", "content": "doxorubicin [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.", "tokenized_content": [2, 12377, 3, 3939, 4604, 5532, 1927, 12377, 12, 25622, 7898, 13, 17, 7630, 26898, 19627, 6897, 18, 3]}, "items": [{"id": "p_2268", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2269", "content": "adriamycin [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.", "tokenized_content": [2, 25622, 7898, 3, 3939, 4604, 5532, 1927, 12377, 12, 25622, 7898, 13, 17, 7630, 26898, 19627, 6897, 18, 3]}, "items": [{"id": "p_2269", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2270", "content": "cyanoacrylate [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.", "tokenized_content": [2, 26898, 19627, 3, 3939, 4604, 5532, 1927, 12377, 12, 25622, 7898, 13, 17, 7630, 26898, 19627, 6897, 18, 3]}, "items": [{"id": "p_2270", "content": "Cyanoacrylates [SEP] A group of compounds having the general formula CH2=C(CN)-COOR; it polymerizes on contact with moisture; used as tissue adhesive", "score": 1, "type": null, "tokenized_content": [2, 26898, 19627, 1036, 3, 43, 2210, 1927, 4300, 4537, 1920, 3335, 9378, 11164, 33, 45, 12, 5940, 13, 17, 2081, 1924, 31, 2176, 4593, 4517, 1990, 5217, 1956, 15490, 31, 2251, 1966, 2960, 13510, 3]}]}
{"query": {"id": "q_2271", "content": "doxorubicin [SEP] Acute doxorubicin-loaded nanoparticle (DXNP) renal toxicity was explored in both ", "tokenized_content": [2, 12377, 3, 3939, 12377, 17, 7630, 13226, 12, 14852, 6708, 13, 4604, 5532, 1982, 7255, 1922, 2321, 3]}, "items": [{"id": "p_2271", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2272", "content": "renal toxicity [SEP] Acute doxorubicin-loaded nanoparticle (DXNP) renal toxicity was explored in both normal rats and rats with experimental glo", "tokenized_content": [2, 4604, 5532, 3, 3939, 12377, 17, 7630, 13226, 12, 14852, 6708, 13, 4604, 5532, 1982, 7255, 1922, 2321, 2791, 3615, 1930, 3615, 1956, 3599, 25632, 3]}, "items": [{"id": "p_2272", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2273", "content": "glomerulonephritis [SEP] ity was explored in both normal rats and rats with experimental glomerulonephritis. In normal rats, 2/6 rats given free doxorubicin (DX) (5 mg/kg)", "tokenized_content": [2, 27057, 3, 2176, 1012, 1982, 7255, 1922, 2321, 2791, 3615, 1930, 3615, 1956, 3599, 27057, 18, 1922, 2791, 3615, 16, 22, 19, 26, 3615, 3258, 3294, 12377, 12, 14852, 13, 3]}, "items": [{"id": "p_2273", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_2274", "content": "DX [SEP] Acute doxorubicin-loaded nanoparticle (DXNP) renal toxicity was explored in both normal rats and rats wit", "tokenized_content": [2, 14852, 3, 3939, 12377, 17, 7630, 13226, 12, 14852, 6708, 13, 4604, 5532, 1982, 7255, 1922, 2321, 2791, 3615, 1930, 3615, 16086, 3]}, "items": [{"id": "p_2274", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2275", "content": "proteinuria [SEP] rats having received free NP or DXNP survived. A 3 times higher proteinuria appeared in animals treated with DXNP than in those treated wit", "tokenized_content": [2, 15831, 3, 3615, 4537, 4004, 3294, 5007, 2014, 14852, 6708, 13985, 18, 43, 23, 3586, 2580, 15831, 6209, 1922, 3555, 2868, 1956, 14852, 6708, 2254, 1922, 2690, 2868, 16086, 3]}, "items": [{"id": "p_2275", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2276", "content": "Proteinuria [SEP]  animals treated by DXNP, NP, or untreated, which all survived. Proteinuria appeared in all series, but was 2-5 times more intense (p > 0.0", "tokenized_content": [2, 15831, 3, 3555, 2868, 2007, 14852, 6708, 16, 5007, 16, 2014, 6829, 16, 2154, 2136, 13985, 18, 15831, 6209, 1922, 2136, 4696, 16, 2308, 1982, 22, 17, 25, 3586, 2253, 3]}, "items": [{"id": "p_2276", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2277", "content": "nephrosis [SEP] renal toxicity of the former. Both effects (better survival and nephrosis) are most probably related to an enhanced capture of DXNP by ce", "tokenized_content": [2, 7737, 4870, 3, 4604, 5532, 1927, 1920, 8733, 18, 2321, 2564, 12, 3807, 3298, 1930, 7737, 4870, 13, 2032, 2501, 6226, 2712, 1942, 1925, 4256, 7573, 1927, 14852, 6708, 2007, 3]}, "items": [{"id": "p_2277", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_2278", "content": "Etoposide [SEP] Etoposide-related myocardial infarction.", "tokenized_content": [2, 18892, 3, 18892, 17, 2712, 6497, 8358, 18, 3]}, "items": [{"id": "p_2278", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_2279", "content": "myocardial infarction [SEP] Etoposide-related myocardial infarction.", "tokenized_content": [2, 6497, 8358, 3, 18892, 17, 2712, 6497, 8358, 18, 3]}, "items": [{"id": "p_2279", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2280", "content": "myocardial infarction [SEP] The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man w", "tokenized_content": [2, 6497, 8358, 3, 1920, 6564, 1927, 43, 6497, 8358, 1977, 2568, 2256, 5318, 3165, 18892, 16, 1922, 43, 2323, 65, 3]}, "items": [{"id": "p_2280", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2281", "content": "etoposide [SEP] myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease. Poss", "tokenized_content": [2, 18892, 3, 6497, 8358, 1977, 2568, 2256, 5318, 3165, 18892, 16, 1922, 43, 2323, 1956, 2239, 2565, 2790, 1958, 5846, 4003, 2573, 18, 2776, 3]}, "items": [{"id": "p_2281", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_2282", "content": "coronary heart disease [SEP] therapy containing etoposide, in a man with no risk factors for coronary heart disease. Possible causal mechanisms are discussed.", "tokenized_content": [2, 5846, 4003, 2573, 3, 3181, 3165, 18892, 16, 1922, 43, 2323, 1956, 2239, 2565, 2790, 1958, 5846, 4003, 2573, 18, 3216, 9263, 3531, 2032, 5601, 18, 3]}, "items": [{"id": "p_2282", "content": "Coronary Disease [SEP] An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow", "score": 1, "type": null, "tokenized_content": [2, 5846, 2573, 3, 1925, 14093, 2192, 6497, 3183, 8456, 1930, 1920, 4796, 1927, 1920, 5846, 7208, 1942, 9042, 5409, 2877, 3426, 3]}]}
{"query": {"id": "q_2283", "content": "sexual dysfunction [SEP] Subjective assessment of sexual dysfunction of patients on long-term administration of digoxin.", "tokenized_content": [2, 5702, 5273, 3, 9106, 4076, 1927, 5702, 5273, 1927, 2132, 1990, 2815, 17, 2576, 4183, 1927, 28815, 18, 3]}, "items": [{"id": "p_2283", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_2284", "content": "digoxin [SEP] f sexual dysfunction of patients on long-term administration of digoxin.", "tokenized_content": [2, 28815, 3, 48, 5702, 5273, 1927, 2132, 1990, 2815, 17, 2576, 4183, 1927, 28815, 18, 3]}, "items": [{"id": "p_2284", "content": "Digoxin [SEP] A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin", "score": 1, "type": null, "tokenized_content": [2, 28815, 3, 43, 21129, 24970, 7533, 2261, 2926, 4994, 2037, 8225, 1937, 19027, 5499, 31, 2176, 7543, 1927, 2559, 15592, 1930, 1920, 2260, 19602, 2290, 4325, 2325, 22037, 18, 28815, 3]}]}
{"query": {"id": "q_2285", "content": "digoxin [SEP] Various data suggest that male patients who have received digoxin on a longterm basis have increased levels of serum estrogen and", "tokenized_content": [2, 28815, 3, 3425, 2230, 3220, 1988, 4005, 2132, 2746, 2162, 4004, 28815, 1990, 43, 2815, 7890, 4859, 2162, 2502, 2428, 1927, 3256, 7940, 1930, 3]}, "items": [{"id": "p_2285", "content": "Digoxin [SEP] A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin", "score": 1, "type": null, "tokenized_content": [2, 28815, 3, 43, 21129, 24970, 7533, 2261, 2926, 4994, 2037, 8225, 1937, 19027, 5499, 31, 2176, 7543, 1927, 2559, 15592, 1930, 1920, 2260, 19602, 2290, 4325, 2325, 22037, 18, 28815, 3]}]}
{"query": {"id": "q_2286", "content": "estrogen [SEP] ived digoxin on a longterm basis have increased levels of serum estrogen and decreased levels of plasma testosterone and luteinizing hor", "tokenized_content": [2, 7940, 3, 4370, 1919, 28815, 1990, 43, 2815, 7890, 4859, 2162, 2502, 2428, 1927, 3256, 7940, 1930, 3261, 2428, 1927, 3582, 10592, 1930, 21600, 3903, 7114, 3]}, "items": [{"id": "p_2286", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_2287", "content": "testosterone [SEP] creased levels of serum estrogen and decreased levels of plasma testosterone and luteinizing hormone (LH). This study was undertaken to inve", "tokenized_content": [2, 10592, 3, 3478, 2148, 2428, 1927, 3256, 7940, 1930, 3261, 2428, 1927, 3582, 10592, 1930, 21600, 3903, 6365, 12, 9107, 13, 18, 2052, 2161, 1982, 10466, 1942, 2269, 1021, 3]}, "items": [{"id": "p_2287", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_2288", "content": "estradiol [SEP]  sexual behavior, and the effect of digoxin on plasma levels of estradiol, testosterone, and LH. The patients of the study and control gr", "tokenized_content": [2, 11513, 3, 5702, 3379, 16, 1930, 1920, 2495, 1927, 28815, 1990, 3582, 2428, 1927, 11513, 16, 10592, 16, 1930, 9107, 18, 1920, 2132, 1927, 1920, 2161, 1930, 2285, 2398, 3]}, "items": [{"id": "p_2288", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_2289", "content": "rheumatic heart disease [SEP] acity and age (25-40 years) and were randomly selected from the rheumatic heart disease patients. A subjective assessment of sexual behavior in the stu", "tokenized_content": [2, 22806, 4003, 2573, 3, 2000, 1999, 1930, 2632, 12, 2637, 17, 3040, 2739, 13, 1930, 1985, 6266, 3790, 2037, 1920, 22806, 4003, 2573, 2132, 18, 43, 9106, 4076, 1927, 5702, 3]}, "items": [{"id": "p_2289", "content": "Rheumatic Heart Disease [SEP] Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any p", "score": 1, "type": null, "tokenized_content": [2, 22806, 4003, 2573, 3, 4435, 15570, 1927, 5510, 10939, 2477, 2961, 16, 2427, 1966, 22806, 9087, 18, 22806, 4003, 2573, 2112, 8156, 2967, 58, 3]}]}
{"query": {"id": "q_2290", "content": "decrease in sexual desire [SEP] to evaluate the changes in sexual behavior showed a significant decrease in sexual desire, sexual excitement phase (erection), and frequency of sexual re", "tokenized_content": [2, 3714, 1922, 5702, 15917, 3, 1942, 4323, 1920, 2840, 1922, 5702, 3379, 2594, 43, 2228, 3714, 1922, 5702, 15917, 16, 5702, 7817, 2855, 3193, 12, 24311, 1929, 13, 16, 1930, 3]}, "items": [{"id": "p_2290", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_2291", "content": "aplastic anemia [SEP] Fatal aplastic anemia due to indomethacin--lymphocyte transformation tests in vitro.", "tokenized_content": [2, 18373, 4054, 10679, 3, 11990, 18373, 4054, 10679, 2810, 1942, 20463, 17, 17, 10009, 7002, 4026, 1922, 3596, 18, 3]}, "items": [{"id": "p_2291", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_2292", "content": "indomethacin [SEP] Fatal aplastic anemia due to indomethacin--lymphocyte transformation tests in vitro.", "tokenized_content": [2, 20463, 3, 11990, 18373, 4054, 10679, 2810, 1942, 20463, 17, 17, 10009, 7002, 4026, 1922, 3596, 18, 3]}, "items": [{"id": "p_2292", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_2293", "content": "indomethacin [SEP] Although indomethacin has been implicated as a possible cause of aplastic anemia on t", "tokenized_content": [2, 20463, 3, 2876, 20463, 2258, 2252, 6835, 1966, 43, 3216, 3936, 1927, 18373, 4054, 10679, 1990, 62, 3]}, "items": [{"id": "p_2293", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_2294", "content": "aplastic anemia [SEP] lthough indomethacin has been implicated as a possible cause of aplastic anemia on the basis of a few clinical observations, its role has not b", "tokenized_content": [2, 18373, 4054, 10679, 3, 3457, 15492, 2509, 20463, 2258, 2252, 6835, 1966, 43, 3216, 3936, 1927, 18373, 4054, 10679, 1990, 1920, 4859, 1927, 43, 3855, 2535, 5184, 16, 2496, 2770, 3]}, "items": [{"id": "p_2294", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_2295", "content": "allopurinol [SEP] fatal aplastic anemia is described in which no drugs other than allopurinol and indomethacin were given. Indomethacin was first given four ", "tokenized_content": [2, 24551, 13076, 1945, 3, 11990, 18373, 4054, 10679, 1977, 2910, 1922, 2154, 2239, 4195, 2303, 2254, 24551, 13076, 1945, 1930, 20463, 1985, 3258, 18, 20463, 1982, 2561, 3258, 3006, 3]}, "items": [{"id": "p_2295", "content": "Allopurinol [SEP] A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.\n ", "score": 1, "type": null, "tokenized_content": [2, 24551, 13076, 1945, 3, 43, 26059, 10488, 4106, 1988, 6386, 17607, 2687, 3372, 18, 2176, 2222, 8016, 1966, 1925, 20330, 9215, 4627, 12191, 2057, 1990, 2673, 20552, 7373, 18, 3]}]}
{"query": {"id": "q_2296", "content": "Indomethacin [SEP] ch no drugs other than allopurinol and indomethacin were given. Indomethacin was first given four weeks prior to the onset of symptoms. A po", "tokenized_content": [2, 20463, 3, 2016, 2239, 4195, 2303, 2254, 24551, 13076, 1945, 1930, 20463, 1985, 3258, 18, 20463, 1982, 2561, 3258, 3006, 3625, 3432, 1942, 1920, 4727, 1927, 3601, 18, 43, 2510, 3]}, "items": [{"id": "p_2296", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_2297", "content": "nephrotic syndrome [SEP] a and urinary lipids and lipoproteins during the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside.", "tokenized_content": [2, 29646, 4741, 3, 43, 1930, 7075, 8238, 1930, 18393, 2409, 1920, 2740, 1927, 29646, 4741, 2719, 1922, 1920, 3067, 2007, 19750, 3835, 1022, 2626, 8028, 18, 3]}, "items": [{"id": "p_2297", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2298", "content": "puromycin aminonucleoside [SEP] ing the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 30393, 1920, 2740, 1927, 29646, 4741, 2719, 1922, 1920, 3067, 2007, 19750, 3835, 1022, 2626, 8028, 18, 3]}, "items": [{"id": "p_2298", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2299", "content": "nephrotic syndrome [SEP] certain whether the alterations of plasma lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephrotic synd", "tokenized_content": [2, 29646, 4741, 3, 4908, 3053, 1920, 5996, 1927, 3582, 18393, 2435, 1922, 29646, 4741, 2719, 2007, 19750, 3835, 1022, 2626, 8028, 1985, 2810, 1942, 29646, 4404, 3]}, "items": [{"id": "p_2299", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2300", "content": "puromycin aminonucleoside [SEP] s of plasma lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephrotic syndrome per se, or, at least in part, to", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 61, 1927, 3582, 18393, 2435, 1922, 29646, 4741, 2719, 2007, 19750, 3835, 1022, 2626, 8028, 1985, 2810, 1942, 29646, 4741, 2079, 2058, 16, 2014, 3]}, "items": [{"id": "p_2300", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2301", "content": "aminonucleoside [SEP] a lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephrotic syndrome per se, or, at least in part, to", "tokenized_content": [2, 3835, 1022, 2626, 8028, 3, 43, 18393, 2435, 1922, 29646, 4741, 2719, 2007, 19750, 3835, 1022, 2626, 8028, 1985, 2810, 1942, 29646, 4741, 2079, 2058, 16, 2014, 16, 2019, 3464, 3]}, "items": [{"id": "p_2301", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2302", "content": "albuminuria [SEP] the subsequent development of nephrotic syndrome. Since massive albuminuria occurred after 6 days of treatment, the time-course study was d", "tokenized_content": [2, 24962, 3, 1920, 4521, 2740, 1927, 29646, 4741, 18, 3328, 12944, 24962, 4807, 2256, 26, 3000, 1927, 2311, 16, 1920, 2367, 17, 4914, 2161, 1982, 46, 3]}, "items": [{"id": "p_2302", "content": "Albuminuria [SEP] The presence of albumin in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24962, 3, 1920, 2990, 1927, 7712, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2303", "content": "nephrotic [SEP] certain whether the alterations of plasma lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephr", "tokenized_content": [2, 29646, 3, 4908, 3053, 1920, 5996, 1927, 3582, 18393, 2435, 1922, 29646, 4741, 2719, 2007, 19750, 3835, 1022, 2626, 8028, 1985, 2810, 1942, 7737, 1005, 3]}, "items": [{"id": "p_2303", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2304", "content": "fatty acids [SEP] ic stage (day 6-11). In pre-nephrotic stage the plasma level of fatty acids, triacylglycerol and VLDL decreased while that of phospholipid,", "tokenized_content": [2, 5934, 4576, 3, 3996, 3587, 12, 3007, 26, 17, 2513, 13, 18, 1922, 2097, 17, 29646, 3587, 1920, 3582, 2237, 1927, 5934, 4576, 16, 5083, 21295, 1930, 21288, 3261, 2679, 3]}, "items": [{"id": "p_2304", "content": "Fatty Acids [SEP] Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and", "score": 1, "type": null, "tokenized_content": [2, 5934, 4576, 3, 6805, 16, 8914, 7972, 12924, 1030, 4576, 3595, 2037, 22318, 2007, 1920, 6582, 1927, 6638, 1927, 43, 4963, 2210, 1942, 1925, 4284, 16, 18727, 16, 1930, 3]}]}
{"query": {"id": "q_2305", "content": "triacylglycerol [SEP]  6-11). In pre-nephrotic stage the plasma level of fatty acids, triacylglycerol and VLDL decreased while that of phospholipid, cholesteryl este", "tokenized_content": [2, 5083, 21295, 3, 26, 17, 2513, 13, 18, 1922, 2097, 17, 29646, 3587, 1920, 3582, 2237, 1927, 5934, 4576, 16, 5083, 21295, 1930, 21288, 3261, 2679, 1988, 1927, 14608, 16, 3]}, "items": [{"id": "p_2305", "content": "Triglycerides [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13631, 3, 3]}]}
{"query": {"id": "q_2306", "content": "cholesteryl esters [SEP]  triacylglycerol and VLDL decreased while that of phospholipid, cholesteryl esters and HDL remained constant. Plasma apolipoprotein A-I tended to ", "tokenized_content": [2, 21211, 2734, 1024, 16785, 3, 5083, 21295, 1930, 21288, 3261, 2679, 1988, 1927, 14608, 16, 21211, 2734, 1024, 16785, 1930, 8210, 5410, 5168, 18, 3582, 18747, 43, 17, 51, 10587, 3]}, "items": [{"id": "p_2306", "content": "Cholesterol Esters [SEP] Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholest", "score": 1, "type": null, "tokenized_content": [2, 5463, 16785, 3, 5934, 2687, 16785, 1927, 5463, 2154, 11480, 3001, 2288, 17, 16071, 1927, 1920, 5463, 1922, 1920, 3582, 18, 1920, 4858, 1927, 21211, 3]}]}
{"query": {"id": "q_2307", "content": "acute hepatic necrosis [SEP] Circulating lysosomal enzymes and acute hepatic necrosis.", "tokenized_content": [2, 3939, 6095, 7476, 3, 7396, 12097, 5038, 1930, 3939, 6095, 7476, 18, 3]}, "items": [{"id": "p_2307", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_2308", "content": "fulminant hepatic failure [SEP] nd acid phosphatase were measured in the serum of patients with fulminant hepatic failure. Acid protease (cathepsin D) activity was increased about tenfo", "tokenized_content": [2, 5257, 8547, 2031, 6095, 4574, 3, 8026, 2687, 8167, 1985, 3045, 1922, 1920, 3256, 1927, 2132, 1956, 5257, 8547, 2031, 6095, 4574, 18, 2687, 7154, 12, 16808, 46, 13, 2455, 3]}, "items": [{"id": "p_2308", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_2309", "content": "paracetamol [SEP]  fourfold in those who survived fulminant hepatic failure after paracetamol overdose, whereas activities were increased equally in patients", "tokenized_content": [2, 27021, 3, 28706, 1922, 2690, 2746, 13985, 5257, 8547, 2031, 6095, 4574, 2256, 27021, 21090, 16, 3417, 4209, 1985, 2502, 9208, 1922, 2132, 3]}, "items": [{"id": "p_2309", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2310", "content": "overdose [SEP]  those who survived fulminant hepatic failure after paracetamol overdose, whereas activities were increased equally in patients with ful", "tokenized_content": [2, 21090, 3, 2690, 2746, 13985, 5257, 8547, 2031, 6095, 4574, 2256, 27021, 21090, 16, 3417, 4209, 1985, 2502, 9208, 1922, 2132, 1956, 5257, 3]}, "items": [{"id": "p_2310", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_2311", "content": "viral hepatitis [SEP] eased equally in patients with fulminant hepatic failure due to viral hepatitis whether or not they survived. A correlation was found between s", "tokenized_content": [2, 4324, 7977, 3, 13832, 1007, 9208, 1922, 2132, 1956, 5257, 8547, 2031, 6095, 4574, 2810, 1942, 4324, 7977, 3053, 2014, 2084, 2611, 13985, 18, 43, 3670, 1982, 2435, 2192, 61, 3]}, "items": [{"id": "p_2311", "content": "Hepatitis, Viral, Human [SEP] INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis wi", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 4324, 16, 2616, 3, 4531, 1927, 1920, 3568, 1922, 5209, 2810, 1942, 2909, 2007, 6241, 18, 2276, 2032, 2980, 2228, 3584, 1927, 2616, 4324, 7977, 11980, 3]}]}
{"query": {"id": "q_2312", "content": "aspartate [SEP] hepsin D activity was sustained over several days compared with aspartate aminotransferase, which showed a sharp early peak and then a fa", "tokenized_content": [2, 12878, 3, 3357, 6777, 46, 2455, 1982, 7637, 2338, 2980, 3000, 2452, 1956, 12878, 15817, 16, 2154, 2594, 43, 11707, 3120, 3833, 1930, 2759, 43, 5685, 3]}, "items": [{"id": "p_2312", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_2313", "content": "tolazamide [SEP] Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy.", "tokenized_content": [2, 21930, 3408, 5482, 3, 2127, 18540, 21524, 14311, 1922, 21930, 3408, 5482, 17, 2719, 22210, 25576, 1021, 11, 61, 19393, 18, 3]}, "items": [{"id": "p_2313", "content": "Tolazamide [SEP] A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21930, 3408, 5482, 3, 43, 13528, 12831, 16648, 24873, 5899, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 4891, 20194, 5482, 18, 3]}]}
{"query": {"id": "q_2314", "content": "Wernicke's encephalopathy [SEP] Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy.", "tokenized_content": [2, 22210, 25576, 1021, 11, 61, 19393, 3, 2127, 18540, 21524, 14311, 1922, 21930, 3408, 5482, 17, 2719, 22210, 25576, 1021, 11, 61, 19393, 18, 3]}, "items": [{"id": "p_2314", "content": "Wernicke Encephalopathy [SEP] An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or con", "score": 1, "type": null, "tokenized_content": [2, 22210, 25576, 1021, 19393, 3, 1925, 3939, 7605, 4770, 4378, 2007, 1920, 21845, 1927, 14554, 4279, 11966, 16, 17698, 16, 1930, 12654, 1927, 5018, 2455, 2014, 1962, 3]}]}
{"query": {"id": "q_2315", "content": "thiamine [SEP] We studied a thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic", "tokenized_content": [2, 26901, 3, 2038, 3942, 43, 26901, 17, 3100, 4113, 16, 2127, 18540, 21524, 16, 2037, 7001, 1927, 43, 6152, 3]}, "items": [{"id": "p_2315", "content": "Thiamine [SEP] 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26901, 3, 23, 17, 12, 12, 24, 17, 3835, 17, 22, 17, 4963, 17, 25, 17, 17015, 7650, 2199, 13, 4963, 13, 17, 25, 17, 12, 22, 17, 8275, 5188, 13, 17, 24, 17, 4963, 28042, 2457, 9140, 18, 3]}]}
{"query": {"id": "q_2316", "content": "diabetic [SEP] thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated wi", "tokenized_content": [2, 6152, 3, 26901, 17, 3100, 4113, 16, 2127, 18540, 21524, 16, 2037, 7001, 1927, 43, 6152, 2774, 2746, 3530, 22210, 25576, 1021, 11, 61, 19393, 2469, 2868, 11980, 3]}, "items": [{"id": "p_2316", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_2317", "content": "Wernicke's encephalopathy [SEP] sketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this pat", "tokenized_content": [2, 22210, 25576, 1021, 11, 61, 19393, 3, 3097, 19446, 24605, 1021, 16, 2037, 7001, 1927, 43, 6152, 2774, 2746, 3530, 22210, 25576, 1021, 11, 61, 19393, 2469, 2868, 1956, 21930, 3]}, "items": [{"id": "p_2317", "content": "Wernicke Encephalopathy [SEP] An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or con", "score": 1, "type": null, "tokenized_content": [2, 22210, 25576, 1021, 19393, 3, 1925, 3939, 7605, 4770, 4378, 2007, 1920, 21845, 1927, 14554, 4279, 11966, 16, 17698, 16, 1930, 12654, 1927, 5018, 2455, 2014, 1962, 3]}]}
{"query": {"id": "q_2318", "content": "tolazamide [SEP] tient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this patient also had transketolase a", "tokenized_content": [2, 21930, 3408, 5482, 3, 19108, 4905, 2746, 3530, 22210, 25576, 1021, 11, 61, 19393, 2469, 2868, 1956, 21930, 3408, 5482, 16, 1922, 3238, 1942, 19222, 2647, 2052, 2774, 2222, 2430, 3]}, "items": [{"id": "p_2318", "content": "Tolazamide [SEP] A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21930, 3408, 5482, 3, 43, 13528, 12831, 16648, 24873, 5899, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 4891, 20194, 5482, 18, 3]}]}
{"query": {"id": "q_2319", "content": "thiamine pyrophosphate [SEP] if this patient also had transketolase abnormality [high Km for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsak", "tokenized_content": [2, 26901, 24937, 3, 2647, 2052, 2774, 2222, 2430, 2127, 18540, 21524, 14311, 37, 2149, 7477, 1958, 26901, 24937, 12, 25282, 13, 39, 16, 1966, 3024, 2568, 1922, 2753, 29576, 22210, 3]}, "items": [{"id": "p_2319", "content": "Thiamine Pyrophosphate [SEP] The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMP", "score": 1, "type": null, "tokenized_content": [2, 26901, 24937, 3, 1920, 22051, 2386, 1927, 6111, 10360, 2481, 1922, 3086, 4027, 3878, 18, 2176, 1977, 43, 3414, 6129, 1922, 1920, 11867, 9294, 2059, 3]}]}
{"query": {"id": "q_2320", "content": "TPP [SEP]  transketolase abnormality [high Km for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff s", "tokenized_content": [2, 25282, 3, 2127, 18540, 21524, 14311, 37, 2149, 7477, 1958, 26901, 24937, 12, 25282, 13, 39, 16, 1966, 3024, 2568, 1922, 2753, 29576, 22210, 25576, 1021, 17, 21136, 5735, 8323, 3]}, "items": [{"id": "p_2320", "content": "Thiamine Pyrophosphate [SEP] The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMP", "score": 1, "type": null, "tokenized_content": [2, 26901, 24937, 3, 1920, 22051, 2386, 1927, 6111, 10360, 2481, 1922, 3086, 4027, 3878, 18, 2176, 1977, 43, 3414, 6129, 1922, 1920, 11867, 9294, 2059, 3]}]}
{"query": {"id": "q_2321", "content": "Wernicke-Korsakoff syndrome [SEP] e pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff syndrome. In addition to this patient, we also studied this enzyme from ", "tokenized_content": [2, 22210, 25576, 1021, 17, 21136, 5735, 8323, 2040, 4741, 3, 47, 24937, 12, 25282, 13, 39, 16, 1966, 3024, 2568, 1922, 2753, 29576, 22210, 25576, 1021, 17, 21136, 5735, 8323, 3]}, "items": [{"id": "p_2321", "content": "Korsakoff Syndrome [SEP] An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is ", "score": 1, "type": null, "tokenized_content": [2, 21136, 5735, 8323, 2040, 4741, 3, 1925, 5815, 4328, 4770, 4378, 2007, 27351, 8956, 2971, 1930, 1920, 11752, 1942, 2386, 3662, 2576, 17921, 18, 2052, 4770, 1977, 3]}]}
{"query": {"id": "q_2322", "content": "myocardial ischemia [SEP] Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischem", "tokenized_content": [2, 6497, 7716, 3, 3531, 1927, 6497, 7716, 2719, 2007, 19280, 30, 3723, 1956, 4975, 17, 2719, 5151, 1987, 3]}, "items": [{"id": "p_2322", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_2323", "content": "epinephrine [SEP] Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischemia.", "tokenized_content": [2, 19280, 3, 3531, 1927, 6497, 7716, 2719, 2007, 19280, 30, 3723, 1956, 4975, 17, 2719, 7716, 18, 3]}, "items": [{"id": "p_2323", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_2324", "content": "ischemia [SEP] Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischem", "tokenized_content": [2, 7716, 3, 3531, 1927, 6497, 7716, 2719, 2007, 19280, 30, 3723, 1956, 4975, 17, 2719, 5151, 1987, 3]}, "items": [{"id": "p_2324", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_2325", "content": "epinephrine [SEP] The role of epinephrine in eliciting myocardial ischemia was examined in patients with ", "tokenized_content": [2, 19280, 3, 1920, 2770, 1927, 19280, 1922, 22451, 6497, 7716, 1982, 3572, 1922, 2132, 1956, 3]}, "items": [{"id": "p_2325", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_2326", "content": "myocardial ischemia [SEP] The role of epinephrine in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objectiv", "tokenized_content": [2, 6497, 7716, 3, 1920, 2770, 1927, 19280, 1922, 22451, 6497, 7716, 1982, 3572, 1922, 2132, 1956, 5846, 5511, 2573, 18, 8032, 2068, 3]}, "items": [{"id": "p_2326", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_2327", "content": "coronary artery disease [SEP]  in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objective signs of ischemia and factors increasing myocardial ", "tokenized_content": [2, 5846, 5511, 2573, 3, 1922, 22451, 6497, 7716, 1982, 3572, 1922, 2132, 1956, 5846, 5511, 2573, 18, 4470, 6879, 1927, 7716, 1930, 2790, 3605, 6497, 3]}, "items": [{"id": "p_2327", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_2328", "content": "ischemia [SEP] The role of epinephrine in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objectiv", "tokenized_content": [2, 7716, 3, 1920, 2770, 1927, 19280, 1922, 22451, 6497, 7716, 1982, 3572, 1922, 2132, 1956, 5846, 5511, 2573, 18, 8032, 2068, 3]}, "items": [{"id": "p_2328", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_2329", "content": "oxygen [SEP] . Objective signs of ischemia and factors increasing myocardial oxygen consumption were compared during epinephrine infusion and supin", "tokenized_content": [2, 4612, 3, 18, 4470, 6879, 1927, 7716, 1930, 2790, 3605, 6497, 4612, 5434, 1985, 2452, 2409, 19280, 7386, 1930, 2302, 1921, 3]}, "items": [{"id": "p_2329", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_2330", "content": "depression [SEP] xercise produced myocardial ischemia as evidenced by ST segment depression and angina. However, the mechanisms of myocardial ischemia indu", "tokenized_content": [2, 4621, 3, 27833, 3349, 4127, 4152, 6497, 7716, 1966, 11400, 2007, 1955, 5367, 4621, 1930, 16961, 18, 2406, 16, 1920, 3531, 1927, 6497, 7716, 2063, 1032, 3]}, "items": [{"id": "p_2330", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2331", "content": "angina [SEP] d myocardial ischemia as evidenced by ST segment depression and angina. However, the mechanisms of myocardial ischemia induced by epin", "tokenized_content": [2, 16961, 3, 46, 6497, 7716, 1966, 11400, 2007, 1955, 5367, 4621, 1930, 16961, 18, 2406, 16, 1920, 3531, 1927, 6497, 7716, 2719, 2007, 13872, 1022, 3]}, "items": [{"id": "p_2331", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_2332", "content": "contralateral rotation [SEP] Transient contralateral rotation following unilateral substantia nigra lesion reflects susceptib", "tokenized_content": [2, 10906, 8891, 3, 6809, 10906, 8891, 2894, 12059, 21229, 20102, 5709, 8847, 5055, 3]}, "items": [{"id": "p_2332", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_2333", "content": "amphetamine [SEP] cts susceptibility of the nigrostriatal system to exhaustion by amphetamine.", "tokenized_content": [2, 19057, 3, 15359, 6461, 1927, 1920, 17452, 17414, 21195, 2433, 1942, 19889, 2007, 19057, 18, 3]}, "items": [{"id": "p_2333", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2334", "content": "6-OHDA [SEP] Following unilateral 6-OHDA induced SN lesion, a transient period of contralateral rotation", "tokenized_content": [2, 26, 17, 25737, 3, 2894, 12059, 26, 17, 25737, 2719, 3437, 5709, 16, 43, 6809, 3047, 1927, 10906, 8891, 3]}, "items": [{"id": "p_2334", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_2335", "content": "contralateral rotation [SEP] wing unilateral 6-OHDA induced SN lesion, a transient period of contralateral rotation has been reported to precede the predominant ipsilateral circli", "tokenized_content": [2, 10906, 8891, 3, 12920, 12059, 26, 17, 25737, 2719, 3437, 5709, 16, 43, 6809, 3047, 1927, 10906, 8891, 2258, 2252, 2568, 1942, 25841, 1920, 6136, 13014, 3624, 12191, 3]}, "items": [{"id": "p_2335", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_2336", "content": "ipsilateral circling [SEP] ralateral rotation has been reported to precede the predominant ipsilateral circling. In order to clarify the nature of this initial contralateral r", "tokenized_content": [2, 13014, 3624, 3961, 3, 15906, 4724, 8891, 2258, 2252, 2568, 1942, 25841, 1920, 6136, 13014, 3624, 3961, 18, 1922, 3238, 1942, 11012, 1920, 4899, 1927, 2052, 3754, 10906, 60, 3]}, "items": [{"id": "p_2336", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_2337", "content": "amphetamine [SEP]  effect of the duration of recovery period after the lesion, on amphetamine-induced rotational behavior. Three days post lesion, most rats ", "tokenized_content": [2, 19057, 3, 2495, 1927, 1920, 4392, 1927, 5241, 3047, 2256, 1920, 5709, 16, 1990, 19057, 17, 2719, 16577, 3379, 18, 2559, 3000, 2753, 5709, 16, 2501, 3615, 3]}, "items": [{"id": "p_2337", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2338", "content": "rotational behavior [SEP] ion of recovery period after the lesion, on amphetamine-induced rotational behavior. Three days post lesion, most rats circled predominantly contra", "tokenized_content": [2, 16577, 3379, 3, 4755, 1927, 5241, 3047, 2256, 1920, 5709, 16, 1990, 19057, 17, 2719, 16577, 3379, 18, 2559, 3000, 2753, 5709, 16, 2501, 3615, 12233, 1007, 7700, 2885, 1019, 3]}, "items": [{"id": "p_2338", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_2339", "content": "rotation [SEP] l 6-OHDA induced SN lesion, a transient period of contralateral rotation has been reported to precede the predominant ipsilateral circli", "tokenized_content": [2, 8891, 3, 54, 26, 17, 25737, 2719, 3437, 5709, 16, 43, 6809, 3047, 1927, 10906, 8891, 2258, 2252, 2568, 1942, 25841, 1920, 6136, 13014, 3624, 12191, 3]}, "items": [{"id": "p_2339", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_2340", "content": "lithium [SEP] Thyroid function and urine-concentrating ability during lithium treatment.", "tokenized_content": [2, 14330, 3, 6918, 2347, 1930, 6960, 17, 2587, 2287, 3682, 2409, 14330, 2311, 18, 3]}, "items": [{"id": "p_2340", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2341", "content": "nephrogenic diabetes insipidus [SEP]  cyclase inhibition may be important in the development of both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum ", "tokenized_content": [2, 7737, 14845, 4032, 2346, 2049, 22291, 3, 16526, 3523, 2278, 1998, 2715, 1922, 1920, 2740, 1927, 2321, 7737, 14845, 4032, 2346, 2049, 22291, 1930, 19316, 2409, 14330, 2311, 18, 2038, 3]}, "items": [{"id": "p_2341", "content": "Diabetes Insipidus, Nephrogenic [SEP] A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to re", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 16, 7737, 14845, 3, 43, 3299, 2014, 5815, 4286, 15861, 4770, 4378, 2007, 7733, 29107, 6960, 1930, 14395, 7640, 1952, 6026, 18, 2052, 2625, 1977, 2810, 1942, 1964, 3]}]}
{"query": {"id": "q_2342", "content": "hypothyroidism [SEP] t in the development of both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum thyroxine and urine", "tokenized_content": [2, 19316, 3, 62, 1922, 1920, 2740, 1927, 2321, 7737, 14845, 4032, 2346, 2049, 22291, 1930, 19316, 2409, 14330, 2311, 18, 2038, 3045, 3256, 29423, 1930, 6960, 3]}, "items": [{"id": "p_2342", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_2343", "content": "lithium [SEP] f both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum thyroxine and urine-concentrating ", "tokenized_content": [2, 14330, 3, 48, 2321, 7737, 14845, 4032, 2346, 2049, 22291, 1930, 19316, 2409, 14330, 2311, 18, 2038, 3045, 3256, 29423, 1930, 6960, 17, 2587, 2287, 3]}, "items": [{"id": "p_2343", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2344", "content": "thyroxine [SEP]  and hypothyroidism during lithium treatment. We measured serum thyroxine and urine-concentrating ability (Umax) in response to desmopres", "tokenized_content": [2, 29423, 3, 1930, 19316, 2409, 14330, 2311, 18, 2038, 3045, 3256, 29423, 1930, 6960, 17, 2587, 2287, 3682, 12, 8736, 3013, 13, 1922, 2644, 1942, 17489, 15370, 1036, 3]}, "items": [{"id": "p_2344", "content": "Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an", "score": 1, "type": null, "tokenized_content": [2, 29423, 3, 1920, 3044, 6365, 3595, 2037, 1920, 6918, 8359, 18, 29423, 1977, 6653, 3454, 1920, 8594, 2636, 1927, 6941, 1036, 12, 8914, 13025, 26879, 13, 1925, 3]}]}
{"query": {"id": "q_2345", "content": "Hypothyroidism [SEP] ponse to desmopressin (DDAVP) in 85 patients receiving lithium. Hypothyroidism developed in eight patients while they were taking lithium. Imp", "tokenized_content": [2, 19316, 3, 29557, 1021, 1942, 17489, 16803, 1921, 12, 6758, 2507, 1034, 13, 1922, 5140, 2132, 5962, 14330, 18, 19316, 3530, 1922, 5066, 2132, 2679, 2611, 1985, 6303, 14330, 18, 3]}, "items": [{"id": "p_2345", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_2346", "content": "hypothyroid [SEP] t in the development of both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum thyroxine and ur", "tokenized_content": [2, 3483, 5730, 3, 62, 1922, 1920, 2740, 1927, 2321, 7737, 14845, 4032, 2346, 2049, 22291, 1930, 19316, 2409, 14330, 2311, 18, 2038, 3045, 3256, 29423, 1930, 3674, 3]}, "items": [{"id": "p_2346", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_2347", "content": "azidothymidine [SEP] nsitivity of erythroid progenitor colonies to erythropoietin in azidothymidine treated immunodeficient mice.", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 4246, 23809, 1927, 17226, 9411, 8505, 1942, 25071, 1922, 6352, 15072, 28935, 16408, 2053, 2868, 30297, 2518, 18, 3]}, "items": [{"id": "p_2347", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_2348", "content": "immunodeficient [SEP] progenitor colonies to erythropoietin in azidothymidine treated immunodeficient mice.", "tokenized_content": [2, 30297, 3, 9411, 8505, 1942, 25071, 1922, 6352, 15072, 28935, 16408, 2053, 2868, 30297, 2518, 18, 3]}, "items": [{"id": "p_2348", "content": "Immune Deficiency Disease [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3743, 6179, 2573, 3, 3]}]}
{"query": {"id": "q_2349", "content": "anaemia [SEP] The anaemia induced by 3'-azido-3'dideoxythymidine (AZT) is poorly understo", "tokenized_content": [2, 19682, 3, 1920, 19682, 2719, 2007, 23, 11, 17, 6352, 15072, 17, 23, 11, 2811, 1021, 7221, 28935, 16408, 2053, 12, 28301, 13, 1977, 7865, 4606, 1037, 3]}, "items": [{"id": "p_2349", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_2350", "content": "3'-azido-3'dideoxythymidine [SEP] The anaemia induced by 3'-azido-3'dideoxythymidine (AZT) is poorly understood. We have used a murine model of AIDS", "tokenized_content": [2, 23, 11, 17, 6352, 15072, 17, 23, 11, 2811, 1021, 7221, 28935, 16408, 2053, 3, 1920, 19682, 2719, 2007, 23, 11, 17, 6352, 15072, 17, 23, 11, 2811, 1021, 7221, 3]}, "items": [{"id": "p_2350", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_2351", "content": "AZT [SEP] The anaemia induced by 3'-azido-3'dideoxythymidine (AZT) is poorly understood. We have used a murine model of AIDS, inf", "tokenized_content": [2, 28301, 3, 1920, 19682, 2719, 2007, 23, 11, 17, 6352, 15072, 17, 23, 11, 2811, 1021, 7221, 28935, 16408, 2053, 12, 28301, 13, 1977, 7865, 7372, 18, 2038, 2162, 2251, 3]}, "items": [{"id": "p_2351", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_2352", "content": "AIDS [SEP] dine (AZT) is poorly understood. We have used a murine model of AIDS, infection of female C57BL/6 mice with LP-BM5 murine leukaemia ", "tokenized_content": [2, 8494, 3, 11687, 1021, 12, 28301, 13, 1977, 7865, 7372, 18, 2038, 2162, 2251, 43, 7135, 2322, 1927, 8494, 16, 2909, 1927, 4232, 8408, 19, 26, 2518, 1956, 8182, 17, 3]}, "items": [{"id": "p_2352", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_2353", "content": "infection [SEP] AZT) is poorly understood. We have used a murine model of AIDS, infection of female C57BL/6 mice with LP-BM5 murine leukaemia (MuLV) viru", "tokenized_content": [2, 2909, 3, 28301, 13, 1977, 7865, 7372, 18, 2038, 2162, 2251, 43, 7135, 2322, 1927, 8494, 16, 2909, 1927, 4232, 8408, 19, 26, 2518, 1956, 8182, 17, 3598, 1015, 7135, 3]}, "items": [{"id": "p_2353", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_2354", "content": "leukaemia [SEP] el of AIDS, infection of female C57BL/6 mice with LP-BM5 murine leukaemia (MuLV) virus, to determine if AZT-induced anaemia is due, in pa", "tokenized_content": [2, 23099, 3, 2349, 1927, 8494, 16, 2909, 1927, 4232, 8408, 19, 26, 2518, 1956, 8182, 17, 3598, 1015, 7135, 23099, 12, 2556, 1020, 13, 3413, 16, 1942, 3415, 2647, 28301, 3]}, "items": [{"id": "p_2354", "content": "Leukemia [SEP] A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukoc", "score": 1, "type": null, "tokenized_content": [2, 8111, 3, 43, 7529, 16, 6558, 2573, 1927, 1920, 2877, 17, 7402, 7393, 16, 4378, 2007, 22797, 4031, 1930, 2740, 1927, 5104, 1994, 3]}]}
{"query": {"id": "q_2355", "content": "phenylhydrazine [SEP] propriate for the degree of anaemia observed when compared with phenylhydrazine (PHZ) treated mice. The numbers of BFU-e and the percentage of ", "tokenized_content": [2, 7971, 10806, 10119, 3, 23249, 2057, 1958, 1920, 4647, 1927, 19682, 2528, 2469, 2452, 1956, 7971, 10806, 10119, 12, 2087, 1011, 13, 2868, 2518, 18, 1920, 4630, 1927, 10171, 1032, 3]}, "items": [{"id": "p_2355", "content": "phenylhydrazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7971, 10806, 10119, 3, 3]}]}
{"query": {"id": "q_2356", "content": "PHZ [SEP]  degree of anaemia observed when compared with phenylhydrazine (PHZ) treated mice. The numbers of BFU-e and the percentage of bone ", "tokenized_content": [2, 2087, 1011, 3, 4647, 1927, 19682, 2528, 2469, 2452, 1956, 7971, 10806, 10119, 12, 2087, 1011, 13, 2868, 2518, 18, 1920, 4630, 1927, 10171, 1032, 17, 47, 1930, 1920, 4466, 3]}, "items": [{"id": "p_2356", "content": "phenylhydrazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7971, 10806, 10119, 3, 3]}]}
{"query": {"id": "q_2357", "content": "reticulocytosis [SEP]  and PHZ treated mice with similar degrees of anaemia. However, reticulocytosis was inappropriate for the degree of anaemia observed in AZT tre", "tokenized_content": [2, 18905, 7349, 3, 1930, 2087, 1011, 2868, 2518, 1956, 2551, 6429, 1927, 19682, 18, 2406, 16, 18905, 7349, 1982, 13770, 1958, 1920, 4647, 1927, 19682, 2528, 1922, 28301, 2171, 3]}, "items": [{"id": "p_2357", "content": "Reticulocytosis [SEP] An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE product", "score": 1, "type": null, "tokenized_content": [2, 18905, 7349, 3, 1925, 2760, 1922, 7396, 18905, 3443, 16, 2154, 1977, 2706, 1920, 23284, 1930, 2501, 7214, 6879, 1927, 10843, 15469, 4863, 3]}]}
{"query": {"id": "q_2358", "content": "adriamycin [SEP] Detection of abnormal cardiac adrenergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.", "tokenized_content": [2, 25622, 7898, 3, 3805, 1927, 4552, 4435, 13672, 7428, 2455, 1922, 25622, 7898, 17, 2719, 14141, 1956, 14836, 17, 7151, 17, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 18, 3]}, "items": [{"id": "p_2358", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2359", "content": "cardiomyopathy [SEP] normal cardiac adrenergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.", "tokenized_content": [2, 14141, 3, 2791, 4435, 13672, 7428, 2455, 1922, 25622, 7898, 17, 2719, 14141, 1956, 14836, 17, 7151, 17, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 18, 3]}, "items": [{"id": "p_2359", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2360", "content": "iodine-125-metaiodobenzylguanidine [SEP] ergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.", "tokenized_content": [2, 14836, 17, 7151, 17, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 3, 11949, 1935, 7428, 2455, 1922, 25622, 7898, 17, 2719, 14141, 1956, 14836, 17, 7151, 17, 5880, 13025, 14601, 3]}, "items": [{"id": "p_2360", "content": "3-Iodobenzylguanidine [SEP] A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled for", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 25469, 13058, 2199, 11056, 8150, 27099, 3, 43, 13504, 5802, 5729, 1956, 2487, 5173, 1958, 3878, 1927, 1920, 11739, 7580, 2433, 1930, 2712, 3861, 18, 1920, 18465, 1958, 3]}]}
{"query": {"id": "q_2361", "content": "Radiolabeled metaiodobenzylguanidine [SEP] Radiolabeled metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of", "tokenized_content": [2, 18465, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 3, 18465, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 12, 19410, 1029, 13, 16, 1925, 5729, 1927, 16436, 12, 2069, 13, 16, 3]}, "items": [{"id": "p_2361", "content": "3-Iodobenzylguanidine [SEP] A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled for", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 25469, 13058, 2199, 11056, 8150, 27099, 3, 43, 13504, 5802, 5729, 1956, 2487, 5173, 1958, 3878, 1927, 1920, 11739, 7580, 2433, 1930, 2712, 3861, 18, 1920, 18465, 1958, 3]}]}
{"query": {"id": "q_2362", "content": "MIBG [SEP] Radiolabeled metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of adren", "tokenized_content": [2, 19410, 1029, 3, 18465, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 12, 19410, 1029, 13, 16, 1925, 5729, 1927, 16436, 12, 2069, 13, 16, 10634, 1966, 1925, 3867, 1927, 7206, 3]}, "items": [{"id": "p_2362", "content": "3-Iodobenzylguanidine [SEP] A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled for", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 25469, 13058, 2199, 11056, 8150, 27099, 3, 43, 13504, 5802, 5729, 1956, 2487, 5173, 1958, 3878, 1927, 1920, 11739, 7580, 2433, 1930, 2712, 3861, 18, 1920, 18465, 1958, 3]}]}
{"query": {"id": "q_2363", "content": "norepinephrine [SEP] Radiolabeled metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of adrenergic neuron integrity and fun", "tokenized_content": [2, 16436, 3, 18465, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 12, 19410, 1029, 13, 16, 1925, 5729, 1927, 16436, 12, 2069, 13, 16, 10634, 1966, 1925, 3867, 1927, 13672, 7428, 3]}, "items": [{"id": "p_2363", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_2364", "content": "NE [SEP] ed metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of adrenergic neuron integrity and functio", "tokenized_content": [2, 2069, 3, 3347, 5880, 13025, 14601, 2199, 11056, 8150, 27099, 12, 19410, 1029, 13, 16, 1925, 5729, 1927, 16436, 12, 2069, 13, 16, 10634, 1966, 1925, 3867, 1927, 13672, 7428, 3]}, "items": [{"id": "p_2364", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_2365", "content": "adriamycin [SEP]  adrenergic neuron integrity and function. Using a rat model of adriamycin-induced cardiomyopathy, we tested the hypothesis that abnormal ", "tokenized_content": [2, 25622, 7898, 3, 13672, 7428, 7996, 1930, 2347, 18, 2193, 43, 3067, 2322, 1927, 25622, 7898, 17, 2719, 14141, 16, 2038, 3620, 1920, 4676, 1988, 4552, 3]}, "items": [{"id": "p_2365", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2366", "content": "cardiomyopathy [SEP] integrity and function. Using a rat model of adriamycin-induced cardiomyopathy, we tested the hypothesis that abnormal cardiac adrenergic neur", "tokenized_content": [2, 14141, 3, 7996, 1930, 2347, 18, 2193, 43, 3067, 2322, 1927, 25622, 7898, 17, 2719, 14141, 16, 2038, 3620, 1920, 4676, 1988, 4552, 4435, 13672, 2974, 3]}, "items": [{"id": "p_2366", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2367", "content": "vacuolar degeneration of myocardial cells [SEP] ed dose-dependently in adriamycin cardiomyopathy. The degree of vacuolar degeneration of myocardial cells was analyzed in relation to the duration of adriamycin treatmen", "tokenized_content": [2, 21582, 9174, 1927, 6497, 2094, 3, 3347, 3253, 17, 19898, 1922, 25622, 7898, 14141, 18, 1920, 4647, 1927, 21582, 9174, 1927, 6497, 2094, 1982, 3265, 1922, 6147, 1942, 1920, 4392, 3]}, "items": [{"id": "p_2367", "content": "Vacuolar myopathy [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21582, 25017, 3, 3]}]}
{"query": {"id": "q_2368", "content": "myocardial impairment [SEP] ed cardiac adrenergic neuron activity in the presence of slight myocardial impairment (scattered or focal vacuolar degeneration) indicates that MIBG ", "tokenized_content": [2, 6497, 6159, 3, 3347, 4435, 13672, 7428, 2455, 1922, 1920, 2990, 1927, 4964, 6497, 6159, 12, 15522, 2014, 8083, 21582, 9174, 13, 4538, 1988, 19410, 1029, 3]}, "items": [{"id": "p_2368", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2369", "content": "vacuolar degeneration [SEP] ed dose-dependently in adriamycin cardiomyopathy. The degree of vacuolar degeneration of myocardial cells was analyzed in relation to the duration of", "tokenized_content": [2, 21582, 9174, 3, 3347, 3253, 17, 19898, 1922, 25622, 7898, 14141, 18, 1920, 4647, 1927, 21582, 9174, 1927, 6497, 2094, 1982, 3265, 1922, 6147, 1942, 1920, 4392, 1927, 3]}, "items": [{"id": "p_2369", "content": "Vacuolar myopathy [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21582, 25017, 3, 3]}]}
{"query": {"id": "q_2370", "content": "Amnestic syndrome [SEP] Amnestic syndrome associated with propranolol toxicity: a case report.", "tokenized_content": [2, 14701, 8396, 4741, 3, 14701, 8396, 4741, 2458, 1956, 21395, 5532, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2370", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_2371", "content": "propranolol [SEP] Amnestic syndrome associated with propranolol toxicity: a case report.", "tokenized_content": [2, 21395, 3, 14701, 8396, 4741, 2458, 1956, 21395, 5532, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2371", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2372", "content": "toxicity [SEP] Amnestic syndrome associated with propranolol toxicity: a case report.", "tokenized_content": [2, 5532, 3, 14701, 8396, 4741, 2458, 1956, 21395, 5532, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2372", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2373", "content": "Alzheimer [SEP] An elderly woman developed an Alzheimer-like subacute dementia as a result of propranolol toxicity. Ana", "tokenized_content": [2, 9116, 3, 1925, 7354, 10440, 3530, 1925, 9116, 17, 3189, 25440, 7811, 1966, 43, 3211, 1927, 21395, 5532, 18, 7381, 3]}, "items": [{"id": "p_2373", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_2374", "content": "dementia [SEP] An elderly woman developed an Alzheimer-like subacute dementia as a result of propranolol toxicity. Analysis of the manifestat", "tokenized_content": [2, 7811, 3, 1925, 7354, 10440, 3530, 1925, 9116, 17, 3189, 25440, 7811, 1966, 43, 3211, 1927, 21395, 5532, 18, 2333, 1927, 1920, 7943, 1926, 3]}, "items": [{"id": "p_2374", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_2375", "content": "propranolol [SEP] an developed an Alzheimer-like subacute dementia as a result of propranolol toxicity. Analysis of the manifestations showed that severe imp", "tokenized_content": [2, 21395, 3, 1925, 3530, 1925, 9116, 17, 3189, 25440, 7811, 1966, 43, 3211, 1927, 21395, 5532, 18, 2333, 1927, 1920, 10952, 2594, 1988, 4010, 2754, 3]}, "items": [{"id": "p_2375", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2376", "content": "toxicity [SEP]  an Alzheimer-like subacute dementia as a result of propranolol toxicity. Analysis of the manifestations showed that severe impairment o", "tokenized_content": [2, 5532, 3, 1925, 9116, 17, 3189, 25440, 7811, 1966, 43, 3211, 1927, 21395, 5532, 18, 2333, 1927, 1920, 10952, 2594, 1988, 4010, 6159, 57, 3]}, "items": [{"id": "p_2376", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2377", "content": "ketamine [SEP] SA node of the dog heart in vivo to selective administration of ketamine.", "tokenized_content": [2, 14049, 3, 4611, 6267, 1927, 1920, 6567, 4003, 1922, 3597, 1942, 5328, 4183, 1927, 14049, 18, 3]}, "items": [{"id": "p_2377", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2378", "content": "ketamine [SEP] Effect of ketamine on the SA node of the dog heart was studied in vivo using a sel", "tokenized_content": [2, 14049, 3, 2495, 1927, 14049, 1990, 1920, 4611, 6267, 1927, 1920, 6567, 4003, 1982, 3942, 1922, 3597, 2193, 43, 2484, 3]}, "items": [{"id": "p_2378", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2379", "content": "depression [SEP]  in doses from 100 microgram to 3 mg into the artery produced a depression of the SA nodal activity by a direct action. This depression wa", "tokenized_content": [2, 4621, 3, 1922, 5312, 2037, 2813, 23460, 1942, 23, 2786, 2460, 1920, 5511, 4152, 43, 4621, 1927, 1920, 4611, 13926, 2455, 2007, 43, 3083, 4615, 18, 2052, 4621, 4114, 3]}, "items": [{"id": "p_2379", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2380", "content": "tachycardia [SEP] locker failed to inhibit the occurrence of the ketamine-induced tachycardia, while it was completely abolished in the reserpinized dogs or ", "tokenized_content": [2, 17397, 3, 12756, 1915, 6617, 1942, 2875, 1920, 6564, 1927, 1920, 14049, 17, 2719, 17397, 16, 2679, 2176, 1982, 5796, 10979, 1922, 1920, 1995, 1915, 9512, 2301, 7894, 2014, 3]}, "items": [{"id": "p_2380", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_2381", "content": "succinylcholine [SEP] The use of serum cholinesterase in succinylcholine apnoea.", "tokenized_content": [2, 13791, 2199, 11603, 3, 1920, 2485, 1927, 3256, 15440, 2156, 7124, 4127, 1922, 13791, 2199, 11603, 2100, 26447, 18, 3]}, "items": [{"id": "p_2381", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2382", "content": "apnoea [SEP] The use of serum cholinesterase in succinylcholine apnoea.", "tokenized_content": [2, 2100, 26447, 3, 1920, 2485, 1927, 3256, 15440, 2156, 7124, 4127, 1922, 13791, 2199, 11603, 2100, 26447, 18, 3]}, "items": [{"id": "p_2382", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_2383", "content": "apnoea [SEP] Fifteen patients demonstrating unexpected prolonged apnoea lasting several hours after succinylcholine have been treated b", "tokenized_content": [2, 2100, 26447, 3, 16173, 2132, 7530, 9892, 7171, 2100, 26447, 11671, 2980, 3967, 2256, 13791, 2199, 11603, 2162, 2252, 2868, 44, 3]}, "items": [{"id": "p_2383", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_2384", "content": "succinylcholine [SEP] trating unexpected prolonged apnoea lasting several hours after succinylcholine have been treated by a new preparation of human serum cholinest", "tokenized_content": [2, 13791, 2199, 11603, 3, 3390, 2104, 9892, 7171, 2100, 26447, 11671, 2980, 3967, 2256, 13791, 2199, 11603, 2162, 2252, 2868, 2007, 43, 2814, 6040, 1927, 2616, 3256, 15440, 2156, 3]}, "items": [{"id": "p_2384", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2385", "content": "Orthostatic hypotension [SEP] Orthostatic hypotension occurs following alpha 2-adrenoceptor blockade in chronic prazo", "tokenized_content": [2, 24343, 11494, 16453, 3, 24343, 11494, 16453, 5110, 2894, 4595, 22, 17, 25090, 9847, 1922, 3724, 29041, 1037, 3]}, "items": [{"id": "p_2385", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2386", "content": "prazosin [SEP] nsion occurs following alpha 2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.", "tokenized_content": [2, 29041, 5872, 3, 4246, 2001, 5110, 2894, 4595, 22, 17, 25090, 9847, 1922, 3724, 29041, 5872, 17, 12152, 11993, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_2386", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_2387", "content": "hypertensive [SEP] blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.", "tokenized_content": [2, 11706, 3, 9847, 1922, 3724, 29041, 5872, 17, 12152, 11993, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_2387", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2388", "content": "prazosin [SEP] 1. Studies were performed to evaluate whether chronic prazosin treatment alters the alpha 2-adrenoceptor function for orthosta", "tokenized_content": [2, 29041, 5872, 3, 21, 18, 2351, 1985, 2593, 1942, 4323, 3053, 3724, 29041, 5872, 2311, 13714, 1920, 4595, 22, 17, 25090, 2347, 1958, 24343, 2156, 1019, 3]}, "items": [{"id": "p_2388", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_2389", "content": "hypertensive [SEP] c control of arterial blood pressure in conscious spontaneously hypertensive rats (SHR). 2. Conscious SHR (male 300-350 g) were subjected to", "tokenized_content": [2, 11706, 3, 45, 2285, 1927, 6624, 2877, 3772, 1922, 11993, 12753, 11706, 3615, 12, 6606, 13, 18, 22, 18, 11993, 6606, 12, 4005, 5255, 17, 11936, 49, 13, 1985, 6243, 3]}, "items": [{"id": "p_2389", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2390", "content": "rauwolscine [SEP] ollowing acute administration of prazosin (0.1 mg kg-1 i.p.) or rauwolscine (3 mg kg-1 i.v.). Orthostatic hypotension was determined by the", "tokenized_content": [2, 4313, 27142, 3706, 11388, 3, 2865, 16496, 1941, 3939, 4183, 1927, 29041, 5872, 12, 20, 18, 21, 2786, 3621, 17, 21, 51, 18, 58, 18, 13, 2014, 4313, 27142, 3706, 3]}, "items": [{"id": "p_2390", "content": "Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT", "score": 1, "type": null, "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 43, 4496, 29951, 1956, 4595, 17, 22, 17, 13672, 7472, 2455, 18, 7419, 7969, 17010, 2053, 2258, 2252, 2251, 1966, 43, 15388, 3027, 2479, 1930, 1922, 1920, 2311, 1927, 24311, 1031, 3]}]}
{"query": {"id": "q_2391", "content": "Orthostatic hypotension [SEP] of prazosin (0.1 mg kg-1 i.p.) or rauwolscine (3 mg kg-1 i.v.). Orthostatic hypotension was determined by the average decrease (%) in mean arterial pre", "tokenized_content": [2, 24343, 11494, 16453, 3, 1927, 29041, 5872, 12, 20, 18, 21, 2786, 3621, 17, 21, 51, 18, 58, 18, 13, 2014, 4313, 27142, 3706, 11388, 12, 23, 2786, 3621, 17, 3]}, "items": [{"id": "p_2391", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2392", "content": "orthostatic hypotension [SEP] auwolscine (-16%(-)-33% MAP). However, the head-up tilt induced orthostatic hypotension in the SHR treated with prazosin (-16% MAP, n = 6), but not in ", "tokenized_content": [2, 24343, 11494, 16453, 3, 5759, 1018, 3706, 11388, 12, 17, 2641, 9, 12, 17, 13, 17, 3401, 9, 4446, 13, 18, 2406, 16, 1920, 4469, 17, 2353, 18322, 2719, 24343, 3]}, "items": [{"id": "p_2392", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2393", "content": "bradycardia [SEP] ps of MAP by 19-23% in these rats. 4. The pressor responses and bradycardia to the alpha 1-agonist cirazoline (0.6 and 2 micrograms kg-1 i.", "tokenized_content": [2, 26192, 3, 2742, 1927, 4446, 2007, 2282, 17, 3020, 9, 1922, 2144, 3615, 18, 24, 18, 1920, 3477, 1924, 3387, 1930, 26192, 1942, 1920, 4595, 21, 17, 7829, 3252, 10457, 3]}, "items": [{"id": "p_2393", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2394", "content": "cirazoline [SEP] 4. The pressor responses and bradycardia to the alpha 1-agonist cirazoline (0.6 and 2 micrograms kg-1 i.v.), the alpha 2-agonist Abbott-53", "tokenized_content": [2, 3252, 10457, 2053, 3, 24, 18, 1920, 3477, 1924, 3387, 1930, 26192, 1942, 1920, 4595, 21, 17, 7829, 3252, 10457, 2053, 12, 20, 18, 26, 1930, 22, 13362, 3621, 17, 3]}, "items": [{"id": "p_2394", "content": "cirazoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3252, 10457, 2053, 3, 3]}]}
{"query": {"id": "q_2395", "content": "Abbott-53693 [SEP] irazoline (0.6 and 2 micrograms kg-1 i.v.), the alpha 2-agonist Abbott-53693 (1 and 3 micrograms kg-1 i.v.), and noradrenaline (0.1 and 1.0 ", "tokenized_content": [2, 22625, 17, 4522, 7093, 1010, 3, 3166, 10457, 2053, 12, 20, 18, 26, 1930, 22, 13362, 3621, 17, 21, 51, 18, 64, 18, 13, 16, 1920, 4595, 22, 17, 7829, 3]}, "items": [{"id": "p_2395", "content": "A 53693 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 43, 4522, 7093, 1010, 3, 3]}]}
{"query": {"id": "q_2396", "content": "noradrenaline [SEP] lpha 2-agonist Abbott-53693 (1 and 3 micrograms kg-1 i.v.), and noradrenaline (0.1 and 1.0 micrograms kg-1 i.v.) were determined in conscious", "tokenized_content": [2, 22636, 3, 8182, 2722, 22, 17, 7829, 22625, 17, 4522, 7093, 1010, 12, 21, 1930, 23, 13362, 3621, 17, 21, 51, 18, 64, 18, 13, 16, 1930, 22636, 12, 20, 3]}, "items": [{"id": "p_2396", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_2397", "content": "internal carotid artery thrombosis [SEP] Coexistence of cerebral venous sinus and internal carotid artery thrombosis associated with exogenous sex hormones. A case report.", "tokenized_content": [2, 4495, 9716, 5511, 11354, 3, 23848, 1927, 6329, 8562, 9414, 1930, 4495, 9716, 5511, 11354, 2458, 1956, 8278, 3486, 10224, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2397", "content": "Carotid Artery Thrombosis [SEP] Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading ", "score": 1, "type": null, "tokenized_content": [2, 9716, 5511, 11354, 3, 2877, 15053, 3337, 1922, 2967, 3131, 1927, 1920, 9716, 9345, 18, 2052, 2278, 5074, 9716, 10407, 2014, 10543, 1927, 1920, 8072, 16, 4523, 3]}]}
{"query": {"id": "q_2398", "content": "headache [SEP] A forty-six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days aft", "tokenized_content": [2, 12187, 3, 43, 11270, 17, 3798, 2476, 17, 4156, 23693, 10440, 3530, 12187, 16, 13759, 1930, 13954, 16, 3506, 22637, 9392, 1937, 1930, 11015, 2288, 3000, 2221, 1031, 3]}, "items": [{"id": "p_2398", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2399", "content": "nausea [SEP] A forty-six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after paren", "tokenized_content": [2, 13759, 3, 43, 11270, 17, 3798, 2476, 17, 4156, 23693, 10440, 3530, 12187, 16, 13759, 1930, 13954, 16, 3506, 22637, 9392, 1937, 1930, 11015, 2288, 3000, 2256, 2096, 1917, 3]}, "items": [{"id": "p_2399", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_2400", "content": "vomiting [SEP] six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of ", "tokenized_content": [2, 13954, 3, 3798, 2476, 17, 4156, 23693, 10440, 3530, 12187, 16, 13759, 1930, 13954, 16, 3506, 22637, 9392, 1937, 1930, 11015, 2288, 3000, 2256, 20301, 2485, 1927, 3]}, "items": [{"id": "p_2400", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_2401", "content": "hemiparesis [SEP] emenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of progesterone and e", "tokenized_content": [2, 22637, 9392, 1937, 3, 2391, 12103, 10440, 3530, 12187, 16, 13759, 1930, 13954, 16, 3506, 22637, 9392, 1937, 1930, 11015, 2288, 3000, 2256, 20301, 2485, 1927, 11528, 1930, 47, 3]}, "items": [{"id": "p_2401", "content": "Paresis [SEP] A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe", "score": 1, "type": null, "tokenized_content": [2, 2096, 2600, 3, 43, 3335, 2576, 17714, 1942, 43, 5809, 1942, 5086, 4647, 1927, 12330, 12175, 16, 14647, 2251, 1966, 43, 26023, 1958, 18973, 12, 4010, 3]}]}
{"query": {"id": "q_2402", "content": "seizure [SEP] n developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of progesterone and estradiol. Di", "tokenized_content": [2, 11015, 3, 56, 3530, 12187, 16, 13759, 1930, 13954, 16, 3506, 22637, 9392, 1937, 1930, 11015, 2288, 3000, 2256, 20301, 2485, 1927, 11528, 1930, 11513, 18, 2137, 3]}, "items": [{"id": "p_2402", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2403", "content": "progesterone [SEP] , left hemiparesis and seizure two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admissio", "tokenized_content": [2, 11528, 3, 16, 3506, 22637, 9392, 1937, 1930, 11015, 2288, 3000, 2256, 20301, 2485, 1927, 11528, 1930, 11513, 18, 4032, 9695, 12, 3931, 13, 1982, 2435, 2409, 3034, 2348, 3940, 3]}, "items": [{"id": "p_2403", "content": "Progesterone [SEP] The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTER", "score": 1, "type": null, "tokenized_content": [2, 11528, 3, 1920, 3044, 10759, 4926, 1923, 9507, 1988, 1977, 8366, 5985, 2007, 1920, 13776, 12867, 1989, 1930, 1920, 13752, 18, 11528, 8016, 1990, 1920, 8123, 3]}]}
{"query": {"id": "q_2404", "content": "estradiol [SEP] s and seizure two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed to", "tokenized_content": [2, 11513, 3, 61, 1930, 11015, 2288, 3000, 2256, 20301, 2485, 1927, 11528, 1930, 11513, 18, 4032, 9695, 12, 3931, 13, 1982, 2435, 2409, 7682, 18, 6287, 1942, 3]}, "items": [{"id": "p_2404", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_2405", "content": "Diabetes mellitus [SEP] re two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed tomography showed a h", "tokenized_content": [2, 4032, 9695, 3, 1964, 2288, 3000, 2256, 20301, 2485, 1927, 11528, 1930, 11513, 18, 4032, 9695, 12, 3931, 13, 1982, 2435, 2409, 7682, 18, 6287, 7876, 2594, 43, 50, 3]}, "items": [{"id": "p_2405", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_2406", "content": "DM [SEP] arenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed tomography showed a hemor", "tokenized_content": [2, 3931, 3, 28225, 24661, 1024, 2485, 1927, 11528, 1930, 11513, 18, 4032, 9695, 12, 3931, 13, 1982, 2435, 2409, 7682, 18, 6287, 7876, 2594, 43, 3243, 1924, 3]}, "items": [{"id": "p_2406", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_2407", "content": "hemorrhagic [SEP] s (DM) was found during admission. Computed tomography showed a hemorrhagic infarct in the right frontal lobe and increased density in the ", "tokenized_content": [2, 16052, 3, 61, 12, 3931, 13, 1982, 2435, 2409, 7682, 18, 6287, 7876, 2594, 43, 16052, 13389, 1922, 1920, 3659, 8086, 9581, 1930, 2502, 3824, 1922, 1920, 3]}, "items": [{"id": "p_2407", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2408", "content": "infarct [SEP] ound during admission. Computed tomography showed a hemorrhagic infarct in the right frontal lobe and increased density in the superior", "tokenized_content": [2, 13389, 3, 17208, 10249, 2409, 7682, 18, 6287, 7876, 2594, 43, 16052, 13389, 1922, 1920, 3659, 8086, 9581, 1930, 2502, 3824, 1922, 1920, 6566, 3]}, "items": [{"id": "p_2408", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_2409", "content": "occlusion of the left internal carotid artery [SEP] e superior sagittal sinus (SSS). Left carotid angiography found occlusion of the left internal carotid artery (ICA). Right carotid angiograms failed to show the SSS and infe", "tokenized_content": [2, 10543, 1927, 1920, 3506, 4495, 9716, 5511, 3, 47, 6566, 13486, 9414, 12, 26571, 13, 18, 3506, 9716, 11676, 2435, 10543, 1927, 1920, 3506, 4495, 9716, 5511, 12, 14784, 13, 3]}, "items": [{"id": "p_2409", "content": "Arterial Occlusive Diseases [SEP] Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduce", "score": 1, "type": null, "tokenized_content": [2, 6624, 28715, 3902, 3, 6598, 4028, 2154, 3211, 1922, 1920, 5740, 2014, 4080, 10849, 1927, 9345, 18, 2611, 2032, 4378, 2007, 8138, 4412, 3]}]}
{"query": {"id": "q_2410", "content": "venous sinus thrombosis [SEP] iled to show the SSS and inferior sagittal sinus, suggestive of venous sinus thrombosis. Coexistence of the cerebral artery and the venous sinus occlus", "tokenized_content": [2, 8562, 9414, 11354, 3, 9940, 1007, 1942, 2146, 1920, 26571, 1930, 8756, 13486, 9414, 16, 12855, 1927, 8562, 9414, 11354, 18, 23848, 1927, 1920, 6329, 5511, 1930, 1920, 8562, 9414, 3]}, "items": [{"id": "p_2410", "content": "Sinus Thrombosis, Intracranial [SEP] Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within", "score": 1, "type": null, "tokenized_content": [2, 9414, 11354, 16, 12179, 3, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 13598, 28436, 16, 3103, 11403, 17, 26285, 8562, 5628, 18287, 2651, 3]}]}
{"query": {"id": "q_2411", "content": "Chloroquine [SEP] Chloroquine related complete heart block with blindness: case report.", "tokenized_content": [2, 20813, 3, 20813, 2712, 4080, 4003, 3367, 1956, 19880, 30, 3087, 3809, 18, 3]}, "items": [{"id": "p_2411", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_2412", "content": "heart block [SEP] Chloroquine related complete heart block with blindness: case report.", "tokenized_content": [2, 4003, 3367, 3, 20813, 2712, 4080, 4003, 3367, 1956, 19880, 30, 3087, 3809, 18, 3]}, "items": [{"id": "p_2412", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_2413", "content": "blindness [SEP] Chloroquine related complete heart block with blindness: case report.", "tokenized_content": [2, 19880, 3, 20813, 2712, 4080, 4003, 3367, 1956, 19880, 30, 3087, 3809, 18, 3]}, "items": [{"id": "p_2413", "content": "Blindness [SEP] The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; O", "score": 1, "type": null, "tokenized_content": [2, 19880, 3, 1920, 11752, 1942, 3365, 2014, 1920, 3257, 2014, 3905, 1927, 6262, 1927, 3737, 5458, 18, 2052, 2625, 2278, 1998, 1920, 3211, 1927, 5723, 3902, 31, 57, 3]}]}
{"query": {"id": "q_2414", "content": "chloroquine [SEP] A 27-year old African woman with history of regular chloroquine ingestion presented with progressive deterioration of vision, e", "tokenized_content": [2, 20813, 3, 43, 3225, 17, 2476, 4156, 7050, 10440, 1956, 4403, 1927, 6314, 20813, 14195, 3549, 1956, 7529, 13318, 1927, 9266, 16, 47, 3]}, "items": [{"id": "p_2414", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_2415", "content": "deterioration of vision [SEP] ory of regular chloroquine ingestion presented with progressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopa", "tokenized_content": [2, 13318, 1927, 9266, 3, 2014, 1012, 1927, 6314, 20813, 14195, 3549, 1956, 7529, 13318, 1927, 9266, 16, 9040, 8393, 12169, 12039, 1999, 16, 14633, 26447, 16, 24009, 23612, 1942, 2540, 3]}, "items": [{"id": "p_2415", "content": "Vision, Low [SEP] Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility. ", "score": 1, "type": null, "tokenized_content": [2, 9266, 16, 2330, 3, 9266, 3311, 1942, 1998, 8756, 1942, 2791, 9266, 1966, 5960, 2007, 8131, 7891, 1927, 12320, 16, 3559, 1927, 9266, 16, 2014, 9254, 18, 3]}]}
{"query": {"id": "q_2416", "content": "fatiguability [SEP] estion presented with progressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmo", "tokenized_content": [2, 8393, 12169, 12039, 1999, 3, 3255, 2001, 3549, 1956, 7529, 13318, 1927, 9266, 16, 9040, 8393, 12169, 12039, 1999, 16, 14633, 26447, 16, 24009, 23612, 1942, 2540, 2972, 1923, 15413, 3]}, "items": [{"id": "p_2416", "content": "Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re", "score": 1, "type": null, "tokenized_content": [2, 8656, 3, 1920, 3360, 1927, 12615, 8254, 2894, 43, 3047, 1927, 28187, 16, 5018, 2014, 3841, 16, 4378, 2007, 43, 3261, 4796, 1958, 2778, 1930, 1964, 3]}]}
{"query": {"id": "q_2417", "content": "dyspnoea [SEP] d with progressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmological as", "tokenized_content": [2, 14633, 26447, 3, 46, 1956, 7529, 13318, 1927, 9266, 16, 9040, 8393, 12169, 12039, 1999, 16, 14633, 26447, 16, 24009, 23612, 1942, 2540, 2972, 1923, 15413, 18, 14554, 2477, 1966, 3]}, "items": [{"id": "p_2417", "content": "Dyspnea [SEP] Difficult or labored breathing.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18461, 3, 4571, 2014, 3876, 1919, 11995, 18, 3]}]}
{"query": {"id": "q_2418", "content": "dizziness [SEP] gressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmological assessment re", "tokenized_content": [2, 24009, 3, 2705, 5590, 2320, 13318, 1927, 9266, 16, 9040, 8393, 12169, 12039, 1999, 16, 14633, 26447, 16, 24009, 23612, 1942, 2540, 2972, 1923, 15413, 18, 14554, 2477, 4076, 1964, 3]}, "items": [{"id": "p_2418", "content": "Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24009, 3, 1925, 26385, 2870, 2576, 2154, 2278, 3333, 1942, 43, 7534, 1927, 5067, 2054, 29292, 16, 6269, 1927, 1920, 3515, 16, 2014, 3696, 10611, 1919, 2971, 18, 3]}]}
{"query": {"id": "q_2419", "content": "syncopal attacks [SEP]  vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmological assessment revealed features of chloroquine r", "tokenized_content": [2, 2540, 2972, 1923, 15413, 3, 9266, 16, 9040, 8393, 12169, 12039, 1999, 16, 14633, 26447, 16, 24009, 23612, 1942, 2540, 2972, 1923, 15413, 18, 14554, 2477, 4076, 3404, 4075, 1927, 3]}, "items": [{"id": "p_2419", "content": "Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync", "score": 1, "type": null, "tokenized_content": [2, 26742, 3, 43, 6809, 3257, 1927, 16897, 1930, 17198, 11020, 4189, 2007, 9597, 2877, 3426, 1942, 1920, 3068, 12, 51, 18, 47, 18, 16, 3068, 7716, 13, 18, 2244, 2304, 1030, 3]}]}
{"query": {"id": "q_2420", "content": "retinopathy [SEP] s. Ophthalmological assessment revealed features of chloroquine retinopathy, cardiac assessment revealed features of heart failure and a co", "tokenized_content": [2, 15508, 3, 61, 18, 14554, 2477, 4076, 3404, 4075, 1927, 20813, 15508, 16, 4435, 4076, 3404, 4075, 1927, 4003, 4574, 1930, 43, 2081, 3]}, "items": [{"id": "p_2420", "content": "Retinal Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6943, 3902, 3, 3]}]}
{"query": {"id": "q_2421", "content": "heart failure [SEP] hloroquine retinopathy, cardiac assessment revealed features of heart failure and a complete heart block with right bundle branch block patte", "tokenized_content": [2, 4003, 4574, 3, 8429, 30232, 15520, 15508, 16, 4435, 4076, 3404, 4075, 1927, 4003, 4574, 1930, 43, 4080, 4003, 3367, 1956, 3659, 14142, 6089, 3367, 2917, 2057, 3]}, "items": [{"id": "p_2421", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_2422", "content": "heart block [SEP] ac assessment revealed features of heart failure and a complete heart block with right bundle branch block pattern. The heart block was tre", "tokenized_content": [2, 4003, 3367, 3, 2000, 4076, 3404, 4075, 1927, 4003, 4574, 1930, 43, 4080, 4003, 3367, 1956, 3659, 14142, 6089, 3367, 3114, 18, 1920, 4003, 3367, 1982, 2171, 3]}, "items": [{"id": "p_2422", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_2423", "content": "right bundle branch block [SEP] ealed features of heart failure and a complete heart block with right bundle branch block pattern. The heart block was treated by pacemaker insertion and", "tokenized_content": [2, 3659, 14142, 6089, 3367, 3, 11377, 2824, 4075, 1927, 4003, 4574, 1930, 43, 4080, 4003, 3367, 1956, 3659, 14142, 6089, 3367, 3114, 18, 1920, 4003, 3367, 1982, 2868, 2007, 20876, 3]}, "items": [{"id": "p_2423", "content": "Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU", "score": 1, "type": null, "tokenized_content": [2, 14142, 17, 6089, 3367, 3, 43, 2386, 1927, 4003, 3367, 1922, 2154, 1920, 8287, 4177, 1927, 4003, 21008, 1977, 20291, 2019, 3108, 2340, 1927, 1920, 11208, 1927, 3168, 3]}]}
{"query": {"id": "q_2424", "content": "blind [SEP] usly following chloroquine discontinuation. She however remains blind.", "tokenized_content": [2, 7109, 3, 2022, 1954, 2894, 20813, 14775, 18, 4693, 2406, 4497, 7109, 18, 3]}, "items": [{"id": "p_2424", "content": "Blindness [SEP] The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; O", "score": 1, "type": null, "tokenized_content": [2, 19880, 3, 1920, 11752, 1942, 3365, 2014, 1920, 3257, 2014, 3905, 1927, 6262, 1927, 3737, 5458, 18, 2052, 2625, 2278, 1998, 1920, 3211, 1927, 5723, 3902, 31, 57, 3]}]}
{"query": {"id": "q_2425", "content": "toxicity [SEP] Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivac", "tokenized_content": [2, 5532, 3, 5510, 5532, 1930, 15371, 1922, 25473, 17, 16, 30129, 17909, 10984, 13414, 5966, 17, 16, 2014, 17890, 17370, 1030, 3]}, "items": [{"id": "p_2425", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2426", "content": "bupivacaine [SEP] Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.", "tokenized_content": [2, 25473, 3, 5510, 5532, 1930, 15371, 1922, 25473, 17, 16, 30129, 17909, 10984, 13414, 5966, 17, 16, 2014, 17890, 20026, 17, 15610, 3615, 18, 3]}, "items": [{"id": "p_2426", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2427", "content": "levobupivacaine [SEP] Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.", "tokenized_content": [2, 30129, 17909, 10984, 13414, 5966, 3, 5510, 5532, 1930, 15371, 1922, 25473, 17, 16, 30129, 17909, 10984, 13414, 5966, 17, 16, 2014, 17890, 20026, 17, 15610, 3615, 18, 3]}, "items": [{"id": "p_2427", "content": "levobupivacaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 30129, 17909, 10984, 13414, 5966, 3, 3]}]}
{"query": {"id": "q_2428", "content": "ropivacaine [SEP] oxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.", "tokenized_content": [2, 17890, 20026, 3, 2833, 3610, 1930, 15371, 1922, 25473, 17, 16, 30129, 17909, 10984, 13414, 5966, 17, 16, 2014, 17890, 20026, 17, 15610, 3615, 18, 3]}, "items": [{"id": "p_2428", "content": "ropivacaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17890, 20026, 3, 3]}]}
{"query": {"id": "q_2429", "content": "toxicity [SEP] We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetize", "tokenized_content": [2, 5532, 3, 2038, 2452, 1920, 5510, 5532, 1927, 25473, 16, 30129, 17909, 10984, 13414, 5966, 16, 1930, 17890, 20026, 1922, 6176, 4988, 6931, 3]}, "items": [{"id": "p_2429", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2430", "content": "bupivacaine [SEP] We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also", "tokenized_content": [2, 25473, 3, 2038, 2452, 1920, 5510, 5532, 1927, 25473, 16, 30129, 17909, 10984, 13414, 5966, 16, 1930, 17890, 20026, 1922, 12137, 3615, 18, 2038, 2222, 3]}, "items": [{"id": "p_2430", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2431", "content": "levobupivacaine [SEP] We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the abi", "tokenized_content": [2, 30129, 17909, 10984, 13414, 5966, 3, 2038, 2452, 1920, 5510, 5532, 1927, 25473, 16, 30129, 17909, 10984, 13414, 5966, 16, 1930, 17890, 20026, 1922, 12137, 3615, 18, 2038, 2222, 2452, 3]}, "items": [{"id": "p_2431", "content": "levobupivacaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 30129, 17909, 10984, 13414, 5966, 3, 3]}]}
{"query": {"id": "q_2432", "content": "ropivacaine [SEP] ared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the ability to resuscita", "tokenized_content": [2, 17890, 20026, 3, 2032, 1007, 1920, 5510, 5532, 1927, 25473, 16, 30129, 17909, 10984, 13414, 5966, 16, 1930, 17890, 20026, 1922, 12137, 3615, 18, 2038, 2222, 2452, 1920, 3682, 1942, 3]}, "items": [{"id": "p_2432", "content": "ropivacaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17890, 20026, 3, 3]}]}
{"query": {"id": "q_2433", "content": "Bupivacaine [SEP] resuscitate rats after lethal doses of these local anesthetics. Bupivacaine, levobupivacaine, or ropivacaine was infused at a rate of 2 mg.", "tokenized_content": [2, 25473, 3, 14037, 28698, 3615, 2256, 10470, 5312, 1927, 2144, 3076, 25118, 18, 25473, 16, 30129, 17909, 10984, 13414, 5966, 16, 2014, 17890, 20026, 1982, 15610, 2019, 43, 2769, 1927, 3]}, "items": [{"id": "p_2433", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2434", "content": "asystole [SEP] logram, and arterial pressure were continuously monitored. When asystole was recorded, drug infusion was stopped and a resuscitation seq", "tokenized_content": [2, 1966, 2298, 2456, 3, 3968, 29085, 16, 1930, 6624, 3772, 1985, 10446, 7027, 18, 2469, 1966, 2298, 2456, 1982, 4562, 16, 2838, 7386, 1982, 12032, 1930, 43, 15371, 7724, 3]}, "items": [{"id": "p_2434", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_2435", "content": "Epinephrine [SEP] ug infusion was stopped and a resuscitation sequence was begun. Epinephrine 0.01 mg/kg was administered at 1-min intervals while external c", "tokenized_content": [2, 19280, 3, 12522, 7386, 1982, 12032, 1930, 43, 15371, 3244, 1982, 18619, 18, 19280, 20, 18, 3287, 2786, 19, 3621, 1982, 5254, 2019, 21, 17, 2360, 6087, 2679, 5771, 45, 3]}, "items": [{"id": "p_2435", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_2436", "content": "seizures [SEP] mulative doses of levobupivacaine and ropivacaine that produced seizures were similar and were larger than those of bupivacaine. The cum", "tokenized_content": [2, 10060, 3, 2556, 2178, 5312, 1927, 30129, 17909, 10984, 13414, 5966, 1930, 17890, 20026, 1988, 4152, 10060, 1985, 2551, 1930, 1985, 4327, 2254, 2690, 1927, 25473, 18, 1920, 7394, 3]}, "items": [{"id": "p_2436", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2437", "content": "dysrhythmias [SEP] ivacaine. The cumulative doses of levobupivacaine that produced dysrhythmias and asystole were smaller than the corresponding doses of ropiv", "tokenized_content": [2, 3890, 5004, 4626, 15519, 3, 4370, 19053, 18, 1920, 8274, 5312, 1927, 30129, 17909, 10984, 13414, 5966, 1988, 4152, 3890, 5004, 4626, 15519, 1930, 1966, 2298, 2456, 1985, 5322, 2254, 3]}, "items": [{"id": "p_2437", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2438", "content": "epinephrine [SEP] tations did not differ among groups. However, a smaller dose of epinephrine was required in the Ropivacaine group than in the other groups.", "tokenized_content": [2, 19280, 3, 10687, 2443, 2811, 2084, 2129, 2706, 2671, 18, 2406, 16, 43, 5322, 3253, 1927, 19280, 1982, 3414, 1922, 1920, 17890, 20026, 2210, 2254, 1922, 1920, 2303, 2671, 18, 3]}, "items": [{"id": "p_2438", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_2439", "content": "Ropivacaine [SEP] ups. However, a smaller dose of epinephrine was required in the Ropivacaine group than in the other groups. We conclude that the systemic t", "tokenized_content": [2, 17890, 20026, 3, 15111, 18, 2406, 16, 43, 5322, 3253, 1927, 19280, 1982, 3414, 1922, 1920, 17890, 20026, 2210, 2254, 1922, 1920, 2303, 2671, 18, 2038, 7676, 1988, 1920, 5510, 3]}, "items": [{"id": "p_2439", "content": "ropivacaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17890, 20026, 3, 3]}]}
{"query": {"id": "q_2440", "content": "cardiac arrest [SEP] when administered at the same rate and that ropivacaine-induced cardiac arrest appears to be more susceptible to treatment than that induced b", "tokenized_content": [2, 4435, 8048, 3, 2469, 5254, 2019, 1920, 2841, 2769, 1930, 1988, 17890, 20026, 17, 2719, 4435, 8048, 5107, 1942, 1998, 2253, 7819, 1942, 2311, 2254, 1988, 2719, 44, 3]}, "items": [{"id": "p_2440", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_2441", "content": "22-oxacalcitriol [SEP] 22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low b", "tokenized_content": [2, 2950, 17, 28905, 23327, 4250, 11149, 3, 2950, 17, 28905, 23327, 4250, 11149, 12987, 4067, 30247, 2979, 7834, 2330, 44, 3]}, "items": [{"id": "p_2441", "content": "maxacalcitol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7531, 10973, 8293, 8148, 3, 3]}]}
{"query": {"id": "q_2442", "content": "secondary hyperparathyroidism [SEP] 22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure.", "tokenized_content": [2, 4067, 30247, 3, 2950, 17, 28905, 23327, 4250, 11149, 12987, 4067, 30247, 2979, 7834, 2330, 3622, 9781, 1922, 7894, 1956, 4604, 4574, 18, 3]}, "items": [{"id": "p_2442", "content": "Hyperparathyroidism, Secondary [SEP] Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other", "score": 1, "type": null, "tokenized_content": [2, 30247, 16, 4067, 3, 20756, 4664, 17152, 6365, 5512, 1966, 43, 2644, 1942, 30201, 9358, 18, 2176, 1977, 4189, 2007, 3724, 5245, 4574, 2014, 2303, 3]}]}
{"query": {"id": "q_2443", "content": "low bone turnover [SEP] triol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure.", "tokenized_content": [2, 2330, 3622, 9781, 3, 30224, 1024, 12987, 4067, 30247, 2979, 7834, 2330, 3622, 9781, 1922, 7894, 1956, 4604, 4574, 18, 3]}, "items": [{"id": "p_2443", "content": "Bone Diseases, Metabolic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 3902, 16, 4487, 3, 3]}]}
{"query": {"id": "q_2444", "content": "renal failure [SEP] rparathyroidism without inducing low bone turnover in dogs with renal failure.", "tokenized_content": [2, 4604, 4574, 3, 16454, 5524, 28935, 12245, 2421, 2979, 7834, 2330, 3622, 9781, 1922, 7894, 1956, 4604, 4574, 18, 3]}, "items": [{"id": "p_2444", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_2445", "content": "Calcitriol [SEP] BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in", "tokenized_content": [2, 20400, 29037, 3, 3872, 30, 20400, 29037, 3181, 12987, 3256, 2428, 1927, 17152, 6365, 12, 13330, 13, 1922, 3]}, "items": [{"id": "p_2445", "content": "Calcitriol [SEP] The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxychole", "score": 1, "type": null, "tokenized_content": [2, 20400, 29037, 3, 1920, 15899, 3500, 2386, 1927, 6111, 46, 18, 2176, 1977, 5333, 5985, 1922, 1920, 5245, 2007, 8145, 21319, 1927, 2637, 17, 8275, 22513, 1021, 3]}]}
{"query": {"id": "q_2446", "content": "renal failure [SEP] sses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marke", "tokenized_content": [2, 4604, 4574, 3, 24773, 1036, 3256, 2428, 1927, 17152, 6365, 12, 13330, 13, 1922, 2132, 1956, 4604, 4574, 2308, 2258, 2980, 22841, 16, 2710, 25374, 9358, 1930, 19, 2014, 2937, 3]}, "items": [{"id": "p_2446", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_2447", "content": "hypercalcemia [SEP] atients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to a", "tokenized_content": [2, 25374, 9358, 3, 2019, 6746, 1956, 4604, 4574, 2308, 2258, 2980, 22841, 16, 2710, 25374, 9358, 1930, 19, 2014, 4961, 6412, 1927, 3622, 9781, 16, 2154, 2278, 2949, 1942, 43, 3]}, "items": [{"id": "p_2447", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_2448", "content": "suppression of bone turnover [SEP] ut has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analo", "tokenized_content": [2, 6412, 1927, 3622, 9781, 3, 11112, 2258, 2980, 22841, 16, 2710, 25374, 9358, 1930, 19, 2014, 4961, 6412, 1927, 3622, 9781, 16, 2154, 2278, 2949, 1942, 2041, 17429, 3622, 2573, 3]}, "items": [{"id": "p_2448", "content": "Bone Diseases, Metabolic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 3902, 16, 4487, 3, 3]}]}
{"query": {"id": "q_2449", "content": "adynamic bone disease [SEP] a and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been sho", "tokenized_content": [2, 2041, 17429, 3622, 2573, 3, 43, 1930, 19, 2014, 4961, 6412, 1927, 3622, 9781, 16, 2154, 2278, 2949, 1942, 2041, 17429, 3622, 2573, 18, 43, 2814, 6111, 46, 12980, 16, 3]}, "items": [{"id": "p_2449", "content": "Bone Diseases, Metabolic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 3902, 16, 4487, 3, 3]}]}
{"query": {"id": "q_2450", "content": "vitamin D [SEP] f bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promis", "tokenized_content": [2, 6111, 46, 3, 48, 3622, 9781, 16, 2154, 2278, 2949, 1942, 2041, 17429, 3622, 2573, 18, 43, 2814, 6111, 46, 12980, 16, 2950, 17, 28905, 23327, 4250, 11149, 12, 5843, 3]}, "items": [{"id": "p_2450", "content": "Vitamin D [SEP] A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS ", "score": 1, "type": null, "tokenized_content": [2, 6111, 46, 3, 43, 6111, 1988, 5921, 2321, 17177, 8515, 3236, 3706, 1930, 11949, 5000, 3349, 2070, 3706, 16, 2154, 2162, 1920, 3059, 2495, 1927, 8444, 2014, 22700, 19507, 3441, 3]}]}
{"query": {"id": "q_2451", "content": "22-oxacalcitriol [SEP] ch may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This s", "tokenized_content": [2, 2950, 17, 28905, 23327, 4250, 11149, 3, 2016, 2278, 2949, 1942, 2041, 17429, 3622, 2573, 18, 43, 2814, 6111, 46, 12980, 16, 2950, 17, 28905, 23327, 4250, 11149, 12, 5843, 3]}, "items": [{"id": "p_2451", "content": "maxacalcitol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7531, 10973, 8293, 8148, 3, 3]}]}
{"query": {"id": "q_2452", "content": "OCT [SEP] namic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study ", "tokenized_content": [2, 5843, 3, 5400, 1935, 3622, 2573, 18, 43, 2814, 6111, 46, 12980, 16, 2950, 17, 28905, 23327, 4250, 11149, 12, 5843, 13, 16, 2258, 2252, 2522, 1942, 2162, 6842, 3779, 3]}, "items": [{"id": "p_2452", "content": "maxacalcitol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7531, 10973, 8293, 8148, 3, 3]}]}
{"query": {"id": "q_2453", "content": "impaired renal function [SEP] CT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or", "tokenized_content": [2, 5761, 4604, 2347, 3, 3369, 1990, 3256, 13330, 2428, 1930, 3622, 9781, 1922, 4376, 1927, 2791, 2014, 5761, 4604, 2347, 18, 2860, 30, 14063, 7894, 1985, 3108, 7737, 8955, 1947, 3]}, "items": [{"id": "p_2453", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2454", "content": "phosphate [SEP] sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of pho", "tokenized_content": [2, 5413, 3, 8236, 17, 10497, 12, 8236, 16, 56, 33, 2950, 13, 18, 1920, 3555, 4004, 6442, 5413, 1942, 4826, 13330, 5512, 18, 18032, 3625, 2256, 1920, 6413, 1927, 20175, 3]}, "items": [{"id": "p_2454", "content": "Phosphates [SEP] Inorganic salts of phosphoric acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26473, 3, 13849, 16028, 1927, 3421, 1935, 2687, 18, 3]}]}
{"query": {"id": "q_2455", "content": "calcium [SEP] an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bon", "tokenized_content": [2, 5016, 3, 1925, 3281, 5066, 3221, 18, 6503, 1930, 12438, 8836, 1927, 5016, 1930, 3622, 4714, 1985, 3045, 5264, 1920, 2161, 16, 1930, 7960, 3]}, "items": [{"id": "p_2455", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2456", "content": "renal insufficiency [SEP] ficantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 micr", "tokenized_content": [2, 4604, 14566, 3, 17662, 2031, 1954, 3261, 3256, 13330, 2428, 12722, 2256, 1920, 4408, 1927, 4604, 14566, 18, 1922, 2815, 17, 11982, 4067, 30247, 16, 5843, 12, 20, 18, 5167, 3]}, "items": [{"id": "p_2456", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_2457", "content": "secondary hyperparathyroidism [SEP] on after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the fi", "tokenized_content": [2, 4067, 30247, 3, 1990, 2256, 1920, 4408, 1927, 4604, 14566, 18, 1922, 2815, 17, 11982, 4067, 30247, 16, 5843, 12, 20, 18, 5167, 12517, 19, 3621, 13, 12017, 3256, 13330, 3]}, "items": [{"id": "p_2457", "content": "Hyperparathyroidism, Secondary [SEP] Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other", "score": 1, "type": null, "tokenized_content": [2, 30247, 16, 4067, 3, 20756, 4664, 17152, 6365, 5512, 1966, 43, 2644, 1942, 30201, 9358, 18, 2176, 1977, 4189, 2007, 3724, 5245, 4574, 2014, 2303, 3]}]}
{"query": {"id": "q_2458", "content": "hyperphosphatemia [SEP] These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient", "tokenized_content": [2, 4194, 25324, 6026, 3, 2144, 2564, 1985, 7936, 2007, 9232, 1927, 25374, 9358, 1930, 4194, 25324, 6026, 18, 1922, 3555, 1956, 2791, 4604, 2347, 16, 5843, 2719, 43, 6809, 3]}, "items": [{"id": "p_2458", "content": "Hyperphosphatemia [SEP] A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol ", "score": 1, "type": null, "tokenized_content": [2, 4194, 25324, 6026, 3, 43, 2625, 1927, 20756, 2149, 2237, 1927, 26473, 1922, 1920, 2877, 16, 5394, 2567, 3538, 1920, 2791, 3109, 1927, 20, 18, 5686, 17, 21, 18, 4804, 6397, 3]}]}
{"query": {"id": "q_2459", "content": "fibrosis [SEP] OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In", "tokenized_content": [2, 6769, 3, 5843, 9432, 4552, 3622, 3337, 16, 2427, 1966, 26334, 4169, 4416, 2642, 1930, 6769, 16, 2308, 2811, 2084, 2567, 4238, 1920, 2237, 1927, 3622, 9781, 18, 1922, 3]}, "items": [{"id": "p_2459", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2460", "content": "low bone turnover [SEP] ent of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone dis", "tokenized_content": [2, 2330, 3622, 9781, 3, 8496, 1927, 4067, 30247, 2882, 2176, 3731, 2084, 4769, 2330, 3622, 9781, 1930, 16, 2955, 16, 3731, 2084, 2760, 1920, 2565, 1927, 2041, 17429, 3622, 2054, 3]}, "items": [{"id": "p_2460", "content": "Bone Diseases, Metabolic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 3902, 16, 4487, 3, 3]}]}
{"query": {"id": "q_2461", "content": "non-small cell lung cancer [SEP] Chemotherapy of advanced inoperable non-small cell lung cancer with paclitaxel: a phase II trial.", "tokenized_content": [2, 2447, 17, 2858, 2024, 3614, 2539, 3, 5318, 1927, 5570, 26848, 2116, 2115, 2447, 17, 2858, 2024, 3614, 2539, 1956, 12404, 30, 43, 3193, 2890, 3046, 18, 3]}, "items": [{"id": "p_2461", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_2462", "content": "paclitaxel [SEP] otherapy of advanced inoperable non-small cell lung cancer with paclitaxel: a phase II trial.", "tokenized_content": [2, 12404, 3, 2303, 18644, 1927, 5570, 26848, 2116, 2115, 2447, 17, 2858, 2024, 3614, 2539, 1956, 12404, 30, 43, 3193, 2890, 3046, 18, 3]}, "items": [{"id": "p_2462", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_2463", "content": "Paclitaxel [SEP] Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has demons", "tokenized_content": [2, 12404, 3, 12404, 12, 24411, 31, 23905, 17, 25912, 4687, 27667, 12428, 16, 5946, 30119, 16, 11421, 13, 2258, 2521, 2101, 3]}, "items": [{"id": "p_2463", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_2464", "content": "Taxol [SEP] Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has demonstrated ", "tokenized_content": [2, 24411, 3, 12404, 12, 24411, 31, 23905, 17, 25912, 4687, 27667, 12428, 16, 5946, 30119, 16, 11421, 13, 2258, 3161, 3]}, "items": [{"id": "p_2464", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_2465", "content": "tumor [SEP] onstrated significant antineoplastic activity against different tumor types, notably ovarian and breast carcinoma. Two phase II trial", "tokenized_content": [2, 2798, 3, 24335, 25957, 2228, 29128, 9969, 2455, 3316, 2413, 2798, 3584, 16, 7388, 6751, 1930, 3739, 5373, 18, 2288, 3193, 2890, 3046, 3]}, "items": [{"id": "p_2465", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_2466", "content": "breast carcinoma [SEP] tic activity against different tumor types, notably ovarian and breast carcinoma. Two phase II trials of 24-hour paclitaxel infusions in chemoth", "tokenized_content": [2, 3739, 5373, 3, 18298, 2455, 3316, 2413, 2798, 3584, 16, 7388, 6751, 1930, 3739, 5373, 18, 2288, 3193, 2890, 3848, 1927, 2686, 17, 6231, 12404, 17656, 1922, 12776, 1023, 3]}, "items": [{"id": "p_2466", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_2467", "content": "paclitaxel [SEP] ly ovarian and breast carcinoma. Two phase II trials of 24-hour paclitaxel infusions in chemotherapy-naive patients with stage IIIB or IV ", "tokenized_content": [2, 12404, 3, 7518, 6751, 1930, 3739, 5373, 18, 2288, 3193, 2890, 3848, 1927, 2686, 17, 6231, 12404, 17656, 1922, 5318, 17, 7879, 2132, 1956, 3587, 28428, 2014, 4370, 3]}, "items": [{"id": "p_2467", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_2468", "content": "non-small cell lung cancer [SEP]  infusions in chemotherapy-naive patients with stage IIIB or IV non-small cell lung cancer (NSCLC) reported response rates of 21% and 24%. Leukopenia was ", "tokenized_content": [2, 2447, 17, 2858, 2024, 3614, 2539, 3, 17656, 1922, 5318, 17, 7879, 2132, 1956, 3587, 28428, 2014, 4370, 2447, 17, 2858, 2024, 3614, 2539, 12, 9298, 13, 2568, 2644, 3389, 3]}, "items": [{"id": "p_2468", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_2469", "content": "NSCLC [SEP] aive patients with stage IIIB or IV non-small cell lung cancer (NSCLC) reported response rates of 21% and 24%. Leukopenia was dose li", "tokenized_content": [2, 9298, 3, 9798, 1961, 2132, 1956, 3587, 28428, 2014, 4370, 2447, 17, 2858, 2024, 3614, 2539, 12, 9298, 13, 2568, 2644, 3389, 1927, 2900, 9, 1930, 2686, 9, 18, 5104, 3]}, "items": [{"id": "p_2469", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_2470", "content": "Leukopenia [SEP] ell lung cancer (NSCLC) reported response rates of 21% and 24%. Leukopenia was dose limiting: as many as 62.5% of patients experienced gra", "tokenized_content": [2, 5104, 12903, 3, 20430, 3614, 2539, 12, 9298, 13, 2568, 2644, 3389, 1927, 2900, 9, 1930, 2686, 9, 18, 5104, 12903, 1982, 3253, 8051, 30, 1966, 3086, 1966, 5374, 18, 3]}, "items": [{"id": "p_2470", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_2471", "content": "leukopenia [SEP] dose limiting: as many as 62.5% of patients experienced grade 4 leukopenia. We investigated the efficacy and toxicity of a 3-hour paclitax", "tokenized_content": [2, 5104, 12903, 3, 3253, 8051, 30, 1966, 3086, 1966, 5374, 18, 25, 9, 1927, 2132, 6090, 4927, 24, 5104, 12903, 18, 2038, 3845, 1920, 4348, 1930, 5532, 1927, 43, 23, 3]}, "items": [{"id": "p_2471", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_2472", "content": "toxicity [SEP] xperienced grade 4 leukopenia. We investigated the efficacy and toxicity of a 3-hour paclitaxel infusion in a phase II trial in patients", "tokenized_content": [2, 5532, 3, 15930, 18842, 3877, 4927, 24, 5104, 12903, 18, 2038, 3845, 1920, 4348, 1930, 5532, 1927, 43, 23, 17, 6231, 12404, 7386, 1922, 43, 3193, 2890, 3046, 1922, 2132, 3]}, "items": [{"id": "p_2472", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2473", "content": "toxicities [SEP] ad no change, and 12 had disease progression (24%). Hematologic toxicities were mild: only one patient (2%) developed grade 3 or 4 neutrop", "tokenized_content": [2, 15251, 3, 2041, 2239, 3185, 16, 1930, 2369, 2430, 2573, 4380, 12, 2686, 9, 13, 18, 18251, 15251, 1985, 5809, 30, 2444, 2340, 2774, 12, 22, 9, 13, 3530, 4927, 3]}, "items": [{"id": "p_2473", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2474", "content": "neutropenia [SEP] icities were mild: only one patient (2%) developed grade 3 or 4 neutropenia, while 29% had grade 1 or 2. Grade 1 or 2 polyneuropathy affect", "tokenized_content": [2, 18005, 3, 25272, 3237, 1985, 5809, 30, 2444, 2340, 2774, 12, 22, 9, 13, 3530, 4927, 23, 2014, 24, 18005, 16, 2679, 3230, 9, 2430, 4927, 21, 2014, 22, 18, 3]}, "items": [{"id": "p_2474", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_2475", "content": "polyneuropathy [SEP] de 3 or 4 neutropenia, while 29% had grade 1 or 2. Grade 1 or 2 polyneuropathy affected 56% of patients while only one (2%) experienced severe", "tokenized_content": [2, 15176, 3708, 13117, 3, 2028, 23, 2014, 24, 18005, 16, 2679, 3230, 9, 2430, 4927, 21, 2014, 22, 18, 4927, 21, 2014, 22, 15176, 3708, 13117, 4218, 4489, 9, 1927, 3]}, "items": [{"id": "p_2475", "content": "Polyneuropathies [SEP] Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral dist", "score": 1, "type": null, "tokenized_content": [2, 15176, 3708, 7262, 2062, 3, 3902, 1927, 3137, 5009, 12014, 7159, 18, 15176, 3708, 7262, 2062, 5394, 2032, 4378, 2007, 20410, 16, 7787, 3653, 3]}]}
{"query": {"id": "q_2476", "content": "myalgia [SEP] (2%) experienced severe polyneuropathy. Similarly, grade 1 or 2 myalgia/arthralgia was observed in 63.2% of patients, but only 14.3% ex", "tokenized_content": [2, 3057, 20394, 2126, 3, 12, 22, 9, 13, 6090, 4010, 15176, 3708, 13117, 18, 4852, 16, 4927, 21, 2014, 22, 3057, 20394, 2126, 19, 9273, 7317, 11966, 1982, 2528, 1922, 3]}, "items": [{"id": "p_2476", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_2477", "content": "arthralgia [SEP] erienced severe polyneuropathy. Similarly, grade 1 or 2 myalgia/arthralgia was observed in 63.2% of patients, but only 14.3% experienced g", "tokenized_content": [2, 9273, 7317, 11966, 3, 2668, 11741, 1007, 4010, 15176, 3708, 13117, 18, 4852, 16, 4927, 21, 2014, 22, 3057, 20394, 2126, 19, 9273, 7317, 11966, 1982, 2528, 1922, 4968, 18, 3]}, "items": [{"id": "p_2477", "content": "Arthralgia [SEP] Pain in the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 7317, 11966, 3, 3594, 1922, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_2478", "content": "Nausea [SEP]  in 63.2% of patients, but only 14.3% experienced grade 3 or 4. Nausea and vomiting were infrequent, with 14% of patients experiencing", "tokenized_content": [2, 13759, 3, 1922, 4968, 18, 22, 9, 1927, 2132, 16, 2308, 2444, 2607, 18, 23, 9, 6090, 4927, 23, 2014, 24, 18, 13759, 1930, 13954, 1985, 21587, 16, 1956, 2607, 3]}, "items": [{"id": "p_2478", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_2479", "content": "vomiting [SEP] f patients, but only 14.3% experienced grade 3 or 4. Nausea and vomiting were infrequent, with 14% of patients experiencing grade 1 or 2", "tokenized_content": [2, 13954, 3, 48, 2132, 16, 2308, 2444, 2607, 18, 23, 9, 6090, 4927, 23, 2014, 24, 18, 13759, 1930, 13954, 1985, 21587, 16, 1956, 2607, 9, 1927, 2132, 12511, 4927, 3]}, "items": [{"id": "p_2479", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_2480", "content": "Cerebral hemorrhage [SEP] Cerebral hemorrhage associated with phenylpropanolamine in combination with caffein", "tokenized_content": [2, 6329, 10489, 3, 6329, 10489, 2458, 1956, 7971, 20194, 4296, 3812, 1922, 3921, 1956, 12689, 1921, 3]}, "items": [{"id": "p_2480", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2481", "content": "phenylpropanolamine [SEP] Cerebral hemorrhage associated with phenylpropanolamine in combination with caffeine.", "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 6329, 10489, 2458, 1956, 7971, 20194, 4296, 3812, 1922, 3921, 1956, 14119, 18, 3]}, "items": [{"id": "p_2481", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_2482", "content": "caffeine [SEP] orrhage associated with phenylpropanolamine in combination with caffeine.", "tokenized_content": [2, 14119, 3, 21434, 2722, 2106, 2458, 1956, 7971, 20194, 4296, 3812, 1922, 3921, 1956, 14119, 18, 3]}, "items": [{"id": "p_2482", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_2483", "content": "Phenylpropanolamine [SEP] Phenylpropanolamine (PPA) is a drug that has been associated with serious side effe", "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 1977, 43, 2838, 1988, 2258, 2252, 2458, 1956, 7433, 4159, 2121, 1021, 3]}, "items": [{"id": "p_2483", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_2484", "content": "PPA [SEP] Phenylpropanolamine (PPA) is a drug that has been associated with serious side effects i", "tokenized_content": [2, 27301, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 1977, 43, 2838, 1988, 2258, 2252, 2458, 1956, 7433, 4159, 2564, 51, 3]}, "items": [{"id": "p_2484", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_2485", "content": "stroke [SEP] ug that has been associated with serious side effects including stroke. It is often combined with caffeine in diet preparations and \"l", "tokenized_content": [2, 5235, 3, 12522, 1988, 2258, 2252, 2458, 1956, 7433, 4159, 2564, 2710, 5235, 18, 2176, 1977, 3868, 4252, 1956, 14119, 1922, 3986, 9815, 1930, 6, 54, 3]}, "items": [{"id": "p_2485", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_2486", "content": "caffeine [SEP] erious side effects including stroke. It is often combined with caffeine in diet preparations and \"look-alike\" pills. In order to determ", "tokenized_content": [2, 14119, 3, 2668, 4836, 4159, 2564, 2710, 5235, 18, 2176, 1977, 3868, 4252, 1956, 14119, 1922, 3986, 9815, 1930, 6, 8120, 17, 15356, 3324, 6, 29099, 18, 1922, 3238, 1942, 3]}, "items": [{"id": "p_2486", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_2487", "content": "hypertensive [SEP] rmine if PPA/caffeine can lead to stroke in normotensive and/or hypertensive rats, we administered the combination in six times the allowed ", "tokenized_content": [2, 11706, 3, 10625, 2053, 2647, 27301, 19, 14119, 2112, 2949, 1942, 5235, 1922, 22479, 1930, 19, 2014, 11706, 3615, 16, 2038, 5254, 1920, 3921, 1922, 3798, 3586, 1920, 5563, 3]}, "items": [{"id": "p_2487", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2488", "content": "cerebral hemorrhage [SEP]  for the rats two times per day for five days. Subarachnoid and cerebral hemorrhage was noted in 18% of the hypertensive rats. A single PPA/caffein", "tokenized_content": [2, 6329, 10489, 3, 1958, 1920, 3615, 2288, 3586, 2079, 3007, 1958, 3628, 3000, 18, 23795, 1930, 6329, 10489, 1982, 5040, 1922, 2654, 9, 1927, 1920, 11706, 3615, 18, 43, 2957, 3]}, "items": [{"id": "p_2488", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2489", "content": "hypertension [SEP]  A single PPA/caffeine administration (same dose) lead to acute hypertension in both the normotensive and hypertensive animals. These result", "tokenized_content": [2, 5579, 3, 43, 2957, 27301, 19, 14119, 4183, 12, 2841, 3253, 13, 2949, 1942, 3939, 5579, 1922, 2321, 1920, 22479, 1930, 11706, 3555, 18, 2144, 3211, 3]}, "items": [{"id": "p_2489", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2490", "content": "toxicity [SEP] Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ", "tokenized_content": [2, 5532, 3, 2815, 17, 2576, 4348, 1930, 5532, 1927, 2149, 17, 3253, 15665, 25033, 2830, 1021, 3181, 1958, 6493, 17397, 2014, 3]}, "items": [{"id": "p_2490", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2491", "content": "amiodarone [SEP] Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 2815, 17, 2576, 4348, 1930, 5532, 1927, 2149, 17, 3253, 15665, 25033, 2830, 1021, 3181, 1958, 6493, 17397, 2014, 6493, 13671, 3]}, "items": [{"id": "p_2491", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_2492", "content": "ventricular tachycardia [SEP] -term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.", "tokenized_content": [2, 6493, 17397, 3, 17, 2576, 4348, 1930, 5532, 1927, 2149, 17, 3253, 15665, 25033, 2830, 1021, 3181, 1958, 6493, 17397, 2014, 6493, 13671, 18, 3]}, "items": [{"id": "p_2492", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_2493", "content": "ventricular fibrillation [SEP]  of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.", "tokenized_content": [2, 6493, 13671, 3, 1927, 2149, 17, 3253, 15665, 25033, 2830, 1021, 3181, 1958, 6493, 17397, 2014, 6493, 13671, 18, 3]}, "items": [{"id": "p_2493", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_2494", "content": "Amiodarone [SEP] Amiodarone was administered to 154 patients who had sustained, symptomatic", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 15665, 25033, 2830, 1021, 1982, 5254, 1942, 14396, 2132, 2746, 2430, 7637, 16, 9371, 3]}, "items": [{"id": "p_2494", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_2495", "content": "ventricular tachycardia [SEP] was administered to 154 patients who had sustained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refrac", "tokenized_content": [2, 6493, 17397, 3, 1982, 5254, 1942, 14396, 2132, 2746, 2430, 7637, 16, 9371, 6493, 17397, 12, 12195, 13, 12, 56, 33, 10297, 13, 2014, 43, 4435, 8048, 12, 56, 33, 3]}, "items": [{"id": "p_2495", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_2496", "content": "VT [SEP] atients who had sustained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refractory", "tokenized_content": [2, 12195, 3, 2019, 6746, 2746, 2430, 7637, 16, 9371, 6493, 17397, 12, 12195, 13, 12, 56, 33, 10297, 13, 2014, 43, 4435, 8048, 12, 56, 33, 3480, 13, 1930, 2746, 3]}, "items": [{"id": "p_2496", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_2497", "content": "cardiac arrest [SEP] tained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refractory to conventional antiarrhythmic", "tokenized_content": [2, 4435, 8048, 3, 27896, 5300, 16, 9371, 6493, 17397, 12, 12195, 13, 12, 56, 33, 10297, 13, 2014, 43, 4435, 8048, 12, 56, 33, 3480, 13, 1930, 2746, 1985, 10923, 3]}, "items": [{"id": "p_2497", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_2498", "content": "amiodarone [SEP] mg/day. Sixty-nine percent of patients continued treatment with amiodarone and had no recurrence of symptomatic VT or ventricular fibrilla", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 2786, 19, 3007, 18, 14063, 17, 6360, 3564, 1927, 2132, 7583, 2311, 1956, 15665, 25033, 2830, 1021, 1930, 2430, 2239, 6339, 1927, 9371, 12195, 2014, 3]}, "items": [{"id": "p_2498", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_2499", "content": "ventricular fibrillation [SEP] ment with amiodarone and had no recurrence of symptomatic VT or ventricular fibrillation (VF) over a follow-up of 6 to 52 months (mean +/- standard devi", "tokenized_content": [2, 6493, 13671, 3, 11567, 1956, 15665, 25033, 2830, 1021, 1930, 2430, 2239, 6339, 1927, 9371, 12195, 2014, 6493, 13671, 12, 15691, 13, 2338, 43, 2396, 17, 2353, 1927, 26, 1942, 3]}, "items": [{"id": "p_2499", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_2500", "content": "VF [SEP] ad no recurrence of symptomatic VT or ventricular fibrillation (VF) over a follow-up of 6 to 52 months (mean +/- standard deviatio", "tokenized_content": [2, 15691, 3, 2041, 2239, 6339, 1927, 9371, 12195, 2014, 6493, 13671, 12, 15691, 13, 2338, 43, 2396, 17, 2353, 1927, 26, 1942, 4764, 3221, 12, 2667, 15, 19, 17, 2970, 3]}, "items": [{"id": "p_2500", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_2501", "content": "tremor [SEP] of patients. The most common symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blur", "tokenized_content": [2, 18388, 3, 1927, 2132, 18, 1920, 2501, 3059, 9371, 5246, 5298, 1985, 18388, 2014, 17698, 12, 3259, 9, 13, 16, 13759, 1930, 21810, 12, 28, 9, 13, 16, 3737, 23226, 3]}, "items": [{"id": "p_2501", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_2502", "content": "ataxia [SEP] s. The most common symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%),", "tokenized_content": [2, 17698, 3, 61, 18, 1920, 2501, 3059, 9371, 5246, 5298, 1985, 18388, 2014, 17698, 12, 3259, 9, 13, 16, 13759, 1930, 21810, 12, 28, 9, 13, 16, 3737, 23226, 1036, 3]}, "items": [{"id": "p_2502", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_2503", "content": "nausea [SEP] mmon symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid funct", "tokenized_content": [2, 13759, 3, 2489, 1916, 9371, 5246, 5298, 1985, 18388, 2014, 17698, 12, 3259, 9, 13, 16, 13759, 1930, 21810, 12, 28, 9, 13, 16, 3737, 23226, 1036, 2014, 2266, 29728, 3]}, "items": [{"id": "p_2503", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_2504", "content": "anorexia [SEP] matic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormali", "tokenized_content": [2, 21810, 3, 2888, 1935, 5246, 5298, 1985, 18388, 2014, 17698, 12, 3259, 9, 13, 16, 13759, 1930, 21810, 12, 28, 9, 13, 16, 3737, 23226, 1036, 2014, 2266, 29728, 12, 3]}, "items": [{"id": "p_2504", "content": "Anorexia [SEP] The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of t", "score": 1, "type": null, "tokenized_content": [2, 21810, 3, 1920, 3630, 2014, 3257, 1927, 17990, 7936, 2007, 1925, 26433, 1942, 3959, 1930, 1920, 11752, 1942, 13619, 18, 2176, 1977, 1920, 11266, 6293, 1927, 62, 3]}]}
{"query": {"id": "q_2505", "content": "visual halos or blurring [SEP] eactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormalities (6%) and pulmonary interst", "tokenized_content": [2, 3737, 23226, 1036, 2014, 2266, 29728, 3, 27848, 3104, 1985, 18388, 2014, 17698, 12, 3259, 9, 13, 16, 13759, 1930, 21810, 12, 28, 9, 13, 16, 3737, 23226, 1036, 2014, 3]}, "items": [{"id": "p_2505", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2506", "content": "thyroid function abnormalities [SEP] (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormalities (6%) and pulmonary interstitial infiltrates (5%). Although larg", "tokenized_content": [2, 6918, 2347, 6754, 3, 12, 3259, 9, 13, 16, 13759, 1930, 21810, 12, 28, 9, 13, 16, 3737, 23226, 1036, 2014, 2266, 29728, 12, 26, 9, 13, 16, 6918, 2347, 3]}, "items": [{"id": "p_2506", "content": "Thyroid Diseases [SEP] Pathological processes involving the THYROID GLAND.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6918, 3902, 3, 6598, 4028, 5884, 1920, 6918, 8359, 18, 3]}]}
{"query": {"id": "q_2507", "content": "toxicity [SEP] ory to conventional antiarrhythmic drugs, it causes significant toxicity in approximately 50% of patients. However, when the dose is adj", "tokenized_content": [2, 5532, 3, 2014, 1012, 1942, 5552, 2246, 23246, 4913, 4195, 16, 2176, 5092, 2228, 5532, 1922, 3993, 2761, 9, 1927, 2132, 18, 2406, 16, 2469, 1920, 3253, 1977, 3250, 3]}, "items": [{"id": "p_2507", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2508", "content": "calcium chloride [SEP] Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.", "tokenized_content": [2, 5016, 9140, 3, 2495, 1927, 5016, 9140, 1930, 24, 17, 3835, 18425, 5802, 3181, 1990, 2270, 27085, 5532, 1922, 3615, 18, 3]}, "items": [{"id": "p_2508", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_2509", "content": "4-aminopyridine [SEP] Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.", "tokenized_content": [2, 24, 17, 3835, 18425, 5802, 3, 2495, 1927, 5016, 9140, 1930, 24, 17, 3835, 18425, 5802, 3181, 1990, 2270, 27085, 5532, 1922, 3615, 18, 3]}, "items": [{"id": "p_2509", "content": "4-Aminopyridine [SEP] One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 3835, 18425, 5802, 3, 2340, 1927, 1920, 9057, 4999, 13628, 16, 1956, 4067, 2495, 1990, 5016, 9058, 16, 2154, 1977, 2251, 4994, 1966, 43, 2659, 5229, 1930, 1942, 3]}]}
{"query": {"id": "q_2510", "content": "desipramine [SEP] Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.", "tokenized_content": [2, 2270, 27085, 3, 2495, 1927, 5016, 9140, 1930, 24, 17, 3835, 18425, 5802, 3181, 1990, 2270, 27085, 5532, 1922, 3615, 18, 3]}, "items": [{"id": "p_2510", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_2511", "content": "toxicity [SEP]  of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.", "tokenized_content": [2, 5532, 3, 1927, 5016, 9140, 1930, 24, 17, 3835, 18425, 5802, 3181, 1990, 2270, 27085, 5532, 1922, 3615, 18, 3]}, "items": [{"id": "p_2511", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2512", "content": "Hypotension [SEP] BACKGROUND: Hypotension is a major contributor to mortality in tricyclic antidepressant", "tokenized_content": [2, 16453, 3, 3872, 30, 16453, 1977, 43, 3044, 17679, 1942, 3885, 1922, 12258, 13153, 14183, 3]}, "items": [{"id": "p_2512", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2513", "content": "overdose [SEP] is a major contributor to mortality in tricyclic antidepressant overdose. Recent data suggest that tricyclic antidepressants inhibit cal", "tokenized_content": [2, 21090, 3, 1977, 43, 3044, 17679, 1942, 3885, 1922, 12258, 13153, 14183, 21090, 18, 3505, 2230, 3220, 1988, 12258, 13153, 17722, 2875, 2570, 3]}, "items": [{"id": "p_2513", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_2514", "content": "calcium [SEP] ose. Recent data suggest that tricyclic antidepressants inhibit calcium influx in some tissues. This study addressed the potential role", "tokenized_content": [2, 5016, 3, 3125, 1021, 18, 3505, 2230, 3220, 1988, 12258, 13153, 17722, 2875, 5016, 12403, 1922, 2673, 3878, 18, 2052, 2161, 8441, 1920, 2889, 2770, 3]}, "items": [{"id": "p_2514", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2515", "content": "hypotension [SEP] of calcium channel blockade in tricyclic antidepressant-induced hypotension. METHODS: Two interventions were studied that have been shown p", "tokenized_content": [2, 16453, 3, 1927, 5016, 4999, 9847, 1922, 12258, 13153, 14183, 17, 2719, 16453, 18, 2860, 30, 2288, 4984, 1985, 3942, 1988, 2162, 2252, 2522, 58, 3]}, "items": [{"id": "p_2515", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2516", "content": "CaCl2 [SEP] o improve blood pressure with calcium channel blocker overdose. CaCl2 and 4-aminopyridine. Anesthetized rats received the tricyclic a", "tokenized_content": [2, 13809, 3, 57, 3326, 2877, 3772, 1956, 5016, 4999, 14580, 21090, 18, 13809, 1930, 24, 17, 3835, 18425, 5802, 18, 12137, 3615, 4004, 1920, 12258, 13153, 43, 3]}, "items": [{"id": "p_2516", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_2517", "content": "4-aminopyridine [SEP] blood pressure with calcium channel blocker overdose. CaCl2 and 4-aminopyridine. Anesthetized rats received the tricyclic antidepressant desipr", "tokenized_content": [2, 24, 17, 3835, 18425, 5802, 3, 2877, 3772, 1956, 5016, 4999, 14580, 21090, 18, 13809, 1930, 24, 17, 3835, 18425, 5802, 18, 12137, 3615, 4004, 1920, 12258, 13153, 14183, 2270, 3]}, "items": [{"id": "p_2517", "content": "4-Aminopyridine [SEP] One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 3835, 18425, 5802, 3, 2340, 1927, 1920, 9057, 4999, 13628, 16, 1956, 4067, 2495, 1990, 5016, 9058, 16, 2154, 1977, 2251, 4994, 1966, 43, 2659, 5229, 1930, 1942, 3]}]}
{"query": {"id": "q_2518", "content": "desipramine [SEP] ridine. Anesthetized rats received the tricyclic antidepressant desipramine IP to produce hypotension, QRS prolongation, and bradycardia. F", "tokenized_content": [2, 2270, 27085, 3, 13240, 2053, 18, 12137, 3615, 4004, 1920, 12258, 13153, 14183, 2270, 27085, 5416, 1942, 5074, 16453, 16, 22355, 20334, 16, 1930, 26192, 18, 48, 3]}, "items": [{"id": "p_2518", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_2519", "content": "bradycardia [SEP] nt desipramine IP to produce hypotension, QRS prolongation, and bradycardia. Fifteen min later, animals received CaCl2, NaHCO3, or saline. ", "tokenized_content": [2, 26192, 3, 5891, 2270, 27085, 5416, 1942, 5074, 16453, 16, 22355, 20334, 16, 1930, 26192, 18, 16173, 2360, 3690, 16, 3555, 4004, 13809, 16, 21210, 16, 2014, 5977, 18, 3]}, "items": [{"id": "p_2519", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2520", "content": "NaHCO3 [SEP] on, and bradycardia. Fifteen min later, animals received CaCl2, NaHCO3, or saline. In a second experiment, rats received tricyclic ant", "tokenized_content": [2, 21210, 3, 1990, 16, 1930, 26192, 18, 16173, 2360, 3690, 16, 3555, 4004, 13809, 16, 21210, 16, 2014, 5977, 18, 1922, 43, 2812, 3859, 16, 3615, 4004, 12258, 13153, 4942, 3]}, "items": [{"id": "p_2520", "content": "Sodium Bicarbonate [SEP] A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in", "score": 1, "type": null, "tokenized_content": [2, 5227, 16106, 3, 43, 4511, 16, 14631, 10201, 1988, 1977, 5384, 2251, 1966, 43, 2087, 23811, 5899, 16, 1925, 15428, 24549, 14682, 16, 5510, 25178, 14151, 1930, 1922, 3]}]}
{"query": {"id": "q_2521", "content": "ventricular arrhythmias [SEP] minopyridine failed to improve blood pressure. The incidence of ventricular arrhythmias (p = 0.004) and seizures (p = 0.03) in the CaCl2 group was high", "tokenized_content": [2, 6493, 16934, 3, 2360, 13518, 5802, 6617, 1942, 3326, 2877, 3772, 18, 1920, 4332, 1927, 6493, 16934, 12, 58, 33, 20, 18, 11373, 13, 1930, 10060, 12, 58, 33, 20, 3]}, "items": [{"id": "p_2521", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2522", "content": "seizures [SEP] ssure. The incidence of ventricular arrhythmias (p = 0.004) and seizures (p = 0.03) in the CaCl2 group was higher than the other groups.", "tokenized_content": [2, 10060, 3, 4577, 2027, 18, 1920, 4332, 1927, 6493, 16934, 12, 58, 33, 20, 18, 11373, 13, 1930, 10060, 12, 58, 33, 20, 18, 5167, 13, 1922, 1920, 13809, 2210, 3]}, "items": [{"id": "p_2522", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2523", "content": "central nervous system toxicity [SEP] rats. CaCl2 therapy may possibly worsen both cardiovascular and central nervous system toxicity. These findings do not support a role for calcium channel inhib", "tokenized_content": [2, 4101, 7580, 2433, 5532, 3, 3615, 18, 13809, 3181, 2278, 6553, 27801, 2321, 5321, 1930, 4101, 7580, 2433, 5532, 18, 2144, 3056, 2608, 2084, 3373, 43, 2770, 1958, 5016, 4999, 3]}, "items": [{"id": "p_2523", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_2524", "content": "13-cis-retinoic acid [SEP] Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplant", "tokenized_content": [2, 2590, 17, 5848, 17, 18014, 2687, 3, 3193, 51, 3046, 1927, 2590, 17, 5848, 17, 18014, 2687, 1922, 3069, 1956, 15566, 2894, 3622, 6599, 5192, 3]}, "items": [{"id": "p_2524", "content": "Isotretinoin [SEP] A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has terato", "score": 1, "type": null, "tokenized_content": [2, 9775, 26313, 9024, 3, 43, 12259, 13467, 4467, 5899, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 25403, 22621, 1930, 2980, 2303, 4407, 3902, 18, 1920, 2838, 2258, 18909, 1037, 3]}]}
{"query": {"id": "q_2525", "content": "neuroblastoma [SEP] Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation.", "tokenized_content": [2, 15566, 3, 3193, 51, 3046, 1927, 2590, 17, 5848, 17, 18014, 2687, 1922, 3069, 1956, 15566, 2894, 3622, 6599, 6530, 18, 3]}, "items": [{"id": "p_2525", "content": "Neuroblastoma [SEP] A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by div", "score": 1, "type": null, "tokenized_content": [2, 15566, 3, 43, 3059, 12132, 1927, 3120, 7238, 11894, 2037, 5181, 15248, 2094, 1922, 1920, 11739, 7580, 2433, 16, 1930, 4378, 2007, 6421, 3]}]}
{"query": {"id": "q_2526", "content": "neuroblastoma [SEP] PURPOSE: Treatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustain", "tokenized_content": [2, 15566, 3, 5120, 30, 2311, 1927, 15566, 2024, 3557, 1956, 2590, 17, 5848, 17, 18014, 2687, 12, 5848, 17, 4313, 13, 2112, 3936, 10184, 3]}, "items": [{"id": "p_2526", "content": "Neuroblastoma [SEP] A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by div", "score": 1, "type": null, "tokenized_content": [2, 15566, 3, 43, 3059, 12132, 1927, 3120, 7238, 11894, 2037, 5181, 15248, 2094, 1922, 1920, 11739, 7580, 2433, 16, 1930, 4378, 2007, 6421, 3]}]}
{"query": {"id": "q_2527", "content": "13-cis-retinoic acid [SEP] PURPOSE: Treatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustained inhibition of proliferation. Since", "tokenized_content": [2, 2590, 17, 5848, 17, 18014, 2687, 3, 5120, 30, 2311, 1927, 15566, 2024, 3557, 1956, 2590, 17, 5848, 17, 18014, 2687, 12, 5848, 17, 4313, 13, 2112, 3936, 7637, 3523, 3]}, "items": [{"id": "p_2527", "content": "Isotretinoin [SEP] A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has terato", "score": 1, "type": null, "tokenized_content": [2, 9775, 26313, 9024, 3, 43, 12259, 13467, 4467, 5899, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 25403, 22621, 1930, 2980, 2303, 4407, 3902, 18, 1920, 2838, 2258, 18909, 1037, 3]}]}
{"query": {"id": "q_2528", "content": "cis-RA [SEP] reatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustained inhibition of proliferation. Since cis-RA ", "tokenized_content": [2, 5848, 17, 4313, 3, 1964, 7647, 1927, 15566, 2024, 3557, 1956, 2590, 17, 5848, 17, 18014, 2687, 12, 5848, 17, 4313, 13, 2112, 3936, 7637, 3523, 1927, 4031, 18, 3328, 3]}, "items": [{"id": "p_2528", "content": "Isotretinoin [SEP] A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has terato", "score": 1, "type": null, "tokenized_content": [2, 9775, 26313, 9024, 3, 43, 12259, 13467, 4467, 5899, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 25403, 22621, 1930, 2980, 2303, 4407, 3902, 18, 1920, 2838, 2258, 18909, 1037, 3]}]}
{"query": {"id": "q_2529", "content": "toxicities [SEP] l was designed to determine the maximal-tolerated dosage (MTD), toxicities, and pharmacokinetics of cis-RA administered on an intermittent", "tokenized_content": [2, 15251, 3, 54, 1982, 4609, 1942, 3415, 1920, 7275, 17, 11117, 9998, 12, 24521, 13, 16, 15251, 16, 1930, 14927, 1927, 5848, 17, 4313, 5254, 1990, 1925, 13252, 3]}, "items": [{"id": "p_2529", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2530", "content": "toxicity [SEP]  dose was escalated from 100 to 200 mg/m2/d until dose-limiting toxicity (DLT) was observed. A single intrapatient dose escalation was p", "tokenized_content": [2, 5532, 3, 3253, 1982, 15279, 1981, 2037, 2813, 1942, 2191, 2786, 19, 6056, 19, 46, 4801, 3253, 17, 8051, 5532, 12, 5268, 1031, 13, 1982, 2528, 18, 43, 2957, 17817, 3]}, "items": [{"id": "p_2530", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2531", "content": "hypercalcemia [SEP] ting toxicities in six of nine patients at 200 mg/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash ", "tokenized_content": [2, 25374, 9358, 3, 12347, 1029, 15251, 1922, 3798, 1927, 6360, 2132, 2019, 2191, 2786, 19, 6056, 19, 46, 3063, 25374, 9358, 12, 56, 33, 23, 13, 16, 18469, 12, 56, 3]}, "items": [{"id": "p_2531", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_2532", "content": "rash [SEP] of nine patients at 200 mg/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All t", "tokenized_content": [2, 18469, 3, 1927, 6360, 2132, 2019, 2191, 2786, 19, 6056, 19, 46, 3063, 25374, 9358, 12, 56, 33, 23, 13, 16, 18469, 12, 56, 33, 22, 13, 16, 1930, 10679, 3]}, "items": [{"id": "p_2532", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_2533", "content": "anemia [SEP] t 200 mg/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All toxicities resolved a", "tokenized_content": [2, 10679, 3, 62, 2191, 2786, 19, 6056, 19, 46, 3063, 25374, 9358, 12, 56, 33, 23, 13, 16, 18469, 12, 56, 33, 22, 13, 16, 1930, 10679, 19, 17100, 19, 3]}, "items": [{"id": "p_2533", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_2534", "content": "thrombocytopenia [SEP] g/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All toxicities resolved after cis-RA was d", "tokenized_content": [2, 17100, 3, 49, 19, 6056, 19, 46, 3063, 25374, 9358, 12, 56, 33, 23, 13, 16, 18469, 12, 56, 33, 22, 13, 16, 1930, 10679, 19, 17100, 19, 2391, 2600, 3]}, "items": [{"id": "p_2534", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_2535", "content": "emesis [SEP] ypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All toxicities resolved after cis-RA was disconti", "tokenized_content": [2, 2391, 2600, 3, 21995, 3234, 8515, 3847, 12, 56, 33, 23, 13, 16, 18469, 12, 56, 33, 22, 13, 16, 1930, 10679, 19, 17100, 19, 2391, 2600, 19, 18469, 12, 3]}, "items": [{"id": "p_2535", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_2536", "content": "metastases [SEP]  discontinued. Three complete responses were observed in marrow metastases. Serum levels of 7.4 +/- 3.0 mumol/L (peak) and 4.0 +/- 2.8 mum", "tokenized_content": [2, 8174, 3, 16087, 18, 2559, 4080, 3387, 1985, 2528, 1922, 6599, 8174, 18, 3256, 2428, 1927, 27, 18, 24, 15, 19, 17, 23, 18, 20, 27078, 19, 54, 12, 3833, 3]}, "items": [{"id": "p_2536", "content": "Neoplasm Metastasis [SEP] The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12132, 5967, 3, 1920, 3856, 1927, 43, 12132, 2037, 2340, 3090, 2014, 3131, 1927, 1920, 3362, 1942, 3741, 12597, 2037, 1920, 3065, 3200, 18, 3]}]}
{"query": {"id": "q_2537", "content": "calcium [SEP] nd may be predicted by serum cis-RA levels. Monitoring of serum calcium and cis-RA levels is indicated in future trials.", "tokenized_content": [2, 5016, 3, 8026, 2278, 1998, 4396, 2007, 3256, 5848, 17, 4313, 2428, 18, 5378, 1927, 3256, 5016, 1930, 5848, 17, 4313, 2428, 1977, 3391, 1922, 4115, 3848, 18, 3]}, "items": [{"id": "p_2537", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2538", "content": "calcium chloride [SEP] Effect of calcium chloride on gross behavioural changes produced by carbachol and eserine ", "tokenized_content": [2, 5016, 9140, 3, 2495, 1927, 5016, 9140, 1990, 10461, 11581, 2840, 4152, 2007, 28940, 1930, 2376, 16654, 1021, 3]}, "items": [{"id": "p_2538", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_2539", "content": "carbachol [SEP] ct of calcium chloride on gross behavioural changes produced by carbachol and eserine in cats.", "tokenized_content": [2, 28940, 3, 3369, 1927, 5016, 9140, 1990, 10461, 11581, 2840, 4152, 2007, 28940, 1930, 2376, 16654, 1021, 1922, 12408, 18, 3]}, "items": [{"id": "p_2539", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_2540", "content": "eserine [SEP] chloride on gross behavioural changes produced by carbachol and eserine in cats.", "tokenized_content": [2, 2376, 16654, 1021, 3, 9140, 1990, 10461, 11581, 2840, 4152, 2007, 28940, 1930, 2376, 16654, 1021, 1922, 12408, 18, 3]}, "items": [{"id": "p_2540", "content": "Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c", "score": 1, "type": null, "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 6221, 14504, 2596, 5726, 18, 2176, 2112, 1998, 3730, 12259, 1954, 1942, 1920, 16911, 1019, 18, 2176, 2222, 45, 3]}]}
{"query": {"id": "q_2541", "content": "calcium chloride [SEP] The effect of calcium chloride injected into the cerebral ventricles of group-housed unanaesth", "tokenized_content": [2, 5016, 9140, 3, 1920, 2495, 1927, 5016, 9140, 5624, 2460, 1920, 6329, 21008, 1927, 2210, 17, 12721, 26844, 26243, 2156, 1023, 3]}, "items": [{"id": "p_2541", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_2542", "content": "mydriasis [SEP] k with paws and claws, defense with paws and claws and biting), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and ", "tokenized_content": [2, 15388, 3027, 3932, 3, 53, 1956, 15329, 1036, 1930, 6958, 8327, 16, 9720, 1956, 15329, 1036, 1930, 6958, 8327, 1930, 30202, 13, 16, 15388, 3027, 3932, 16, 18388, 1930, 6138, 3]}, "items": [{"id": "p_2542", "content": "Mydriasis [SEP] Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condit", "score": 1, "type": null, "tokenized_content": [2, 15388, 3027, 3932, 3, 16470, 1927, 29697, 1942, 3430, 2254, 26, 2489, 4252, 1956, 4574, 1927, 1920, 29697, 1942, 15595, 1031, 2469, 5449, 1956, 3696, 18, 2052, 8646, 1932, 3]}]}
{"query": {"id": "q_2543", "content": "tremor [SEP]  and claws, defense with paws and claws and biting), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and eserine ", "tokenized_content": [2, 18388, 3, 1930, 6958, 8327, 16, 9720, 1956, 15329, 1036, 1930, 6958, 8327, 1930, 30202, 13, 16, 15388, 3027, 3932, 16, 18388, 1930, 6138, 1935, 17, 16887, 4772, 19389, 4152, 3]}, "items": [{"id": "p_2543", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_2544", "content": "clonic-tonic convulsions [SEP]  defense with paws and claws and biting), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and eserine injected similarly was invest", "tokenized_content": [2, 6138, 1935, 17, 16887, 4772, 19389, 3, 9720, 1956, 15329, 1036, 1930, 6958, 8327, 1930, 30202, 13, 16, 15388, 3027, 3932, 16, 18388, 1930, 6138, 1935, 17, 16887, 4772, 19389, 3]}, "items": [{"id": "p_2544", "content": "Epilepsy, Tonic-Clonic [SEP] A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 16887, 17, 6138, 1935, 3, 43, 9612, 11015, 4770, 4378, 2007, 7457, 3044, 4842, 10060, 18, 1920, 3754, 5310, 16887, 3193, 1977, 4961, 2007, 13717, 3]}]}
{"query": {"id": "q_2545", "content": "carbachol [SEP] ng), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and eserine injected similarly was investigated. Calcium chlori", "tokenized_content": [2, 28940, 3, 4375, 13, 16, 15388, 3027, 3932, 16, 18388, 1930, 6138, 1935, 17, 16887, 4772, 19389, 4152, 2007, 28940, 1930, 2376, 16654, 1021, 5624, 4852, 1982, 3845, 18, 5016, 3]}, "items": [{"id": "p_2545", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_2546", "content": "eserine [SEP] , tremor and clonic-tonic convulsions produced by carbachol and eserine injected similarly was investigated. Calcium chloride depressed", "tokenized_content": [2, 2376, 16654, 1021, 3, 16, 18388, 1930, 6138, 1935, 17, 16887, 4772, 19389, 4152, 2007, 28940, 1930, 2376, 16654, 1021, 5624, 4852, 1982, 3845, 18, 5016, 9140, 11365, 3]}, "items": [{"id": "p_2546", "content": "Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c", "score": 1, "type": null, "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 6221, 14504, 2596, 5726, 18, 2176, 2112, 1998, 3730, 12259, 1954, 1942, 1920, 16911, 1019, 18, 2176, 2222, 45, 3]}]}
{"query": {"id": "q_2547", "content": "Calcium chloride [SEP] d by carbachol and eserine injected similarly was investigated. Calcium chloride depressed or almost completely abolished the vocalization and f", "tokenized_content": [2, 5016, 9140, 3, 46, 2007, 28940, 1930, 2376, 16654, 1021, 5624, 4852, 1982, 3845, 18, 5016, 9140, 11365, 2014, 5365, 5796, 10979, 1920, 13115, 2466, 1930, 48, 3]}, "items": [{"id": "p_2547", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_2548", "content": "calcium [SEP] The effect of calcium chloride injected into the cerebral ventricles of group-housed ", "tokenized_content": [2, 5016, 3, 1920, 2495, 1927, 5016, 9140, 5624, 2460, 1920, 6329, 21008, 1927, 2210, 17, 12721, 3]}, "items": [{"id": "p_2548", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2549", "content": "atropine [SEP] ts further support the view that calcium ions in excess have an atropine-like action also in the central nervous system.", "tokenized_content": [2, 24031, 3, 4894, 2520, 3373, 1920, 4263, 1988, 5016, 6982, 1922, 5799, 2162, 1925, 24031, 17, 3189, 4615, 2222, 1922, 1920, 4101, 7580, 2433, 18, 3]}, "items": [{"id": "p_2549", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_2550", "content": "penicillamine [SEP] Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.", "tokenized_content": [2, 25142, 3812, 3, 3137, 4159, 2564, 1927, 25142, 3812, 3181, 1922, 2340, 2774, 1956, 13053, 8884, 18, 3]}, "items": [{"id": "p_2550", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_2551", "content": "rheumatoid arthritis [SEP] tiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.", "tokenized_content": [2, 13053, 8884, 3, 7933, 1952, 4159, 2564, 1927, 25142, 3812, 3181, 1922, 2340, 2774, 1956, 13053, 8884, 18, 3]}, "items": [{"id": "p_2551", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_2552", "content": "Skin rashes [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and my", "tokenized_content": [2, 4407, 18469, 1918, 3, 4407, 18469, 1918, 16, 15831, 16, 5510, 13711, 22045, 16, 3491, 25749, 12924, 3600, 1930, 3057, 3]}, "items": [{"id": "p_2552", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_2553", "content": "proteinuria [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia grav", "tokenized_content": [2, 15831, 3, 4407, 18469, 1918, 16, 15831, 16, 5510, 13711, 22045, 16, 3491, 25749, 12924, 3600, 1930, 3057, 27618, 8572, 12413, 3]}, "items": [{"id": "p_2553", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2554", "content": "systemic lupus erythematosus [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as c", "tokenized_content": [2, 5510, 13711, 22045, 3, 4407, 18469, 1918, 16, 15831, 16, 5510, 13711, 22045, 16, 3491, 25749, 12924, 3600, 1930, 3057, 27618, 8572, 12413, 1937, 2162, 2136, 2252, 4562, 1966, 45, 3]}, "items": [{"id": "p_2554", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_2555", "content": "polymyositis [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications o", "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 4407, 18469, 1918, 16, 15831, 16, 5510, 13711, 22045, 16, 3491, 25749, 12924, 3600, 1930, 3057, 27618, 8572, 12413, 1937, 2162, 2136, 2252, 4562, 1966, 3]}, "items": [{"id": "p_2555", "content": "Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi", "score": 1, "type": null, "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3902, 4378, 2007, 4531, 5884, 3137, 7848, 18, 2052, 2278, 4704, 1966, 1925, 3939, 2014, 3724, 2625, 2458, 11980, 3]}]}
{"query": {"id": "q_2556", "content": "myasthenia gravis [SEP] es, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therap", "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 2376, 16, 15831, 16, 5510, 13711, 22045, 16, 3491, 25749, 12924, 3600, 1930, 3057, 27618, 8572, 12413, 1937, 2162, 2136, 2252, 4562, 1966, 5021, 3]}, "items": [{"id": "p_2556", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_2557", "content": "penicillamine [SEP] nd myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis. A patient who ha", "tokenized_content": [2, 25142, 3812, 3, 8026, 3057, 27618, 8572, 12413, 1937, 2162, 2136, 2252, 4562, 1966, 5021, 1927, 25142, 3812, 3181, 1922, 2132, 1956, 13053, 8884, 18, 43, 2774, 2746, 2118, 3]}, "items": [{"id": "p_2557", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_2558", "content": "rheumatoid arthritis [SEP] rded as complications of penicillamine therapy in patients with rheumatoid arthritis. A patient who had developed all 5 is now described. The skin l", "tokenized_content": [2, 13053, 8884, 3, 8695, 1919, 1966, 5021, 1927, 25142, 3812, 3181, 1922, 2132, 1956, 13053, 8884, 18, 43, 2774, 2746, 2430, 3530, 2136, 25, 1977, 5195, 2910, 18, 1920, 4407, 3]}, "items": [{"id": "p_2558", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_2559", "content": "skin lesion [SEP] hritis. A patient who had developed all 5 is now described. The skin lesion resembled elastosis perforans serpiginosa, which has been repor", "tokenized_content": [2, 4407, 5709, 3, 3668, 3678, 18, 43, 2774, 2746, 2430, 3530, 2136, 25, 1977, 5195, 2910, 18, 1920, 4407, 5709, 22795, 15084, 2475, 16946, 2075, 27453, 1950, 11096, 1019, 16, 3]}, "items": [{"id": "p_2559", "content": "Skin Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4407, 3902, 3, 3]}]}
{"query": {"id": "q_2560", "content": "elastosis perforans serpiginosa [SEP] had developed all 5 is now described. The skin lesion resembled elastosis perforans serpiginosa, which has been reported as a rare side effect in patients with", "tokenized_content": [2, 15084, 2475, 16946, 2075, 27453, 1950, 11096, 1019, 3, 2430, 3530, 2136, 25, 1977, 5195, 2910, 18, 1920, 4407, 5709, 22795, 15084, 2475, 16946, 2075, 27453, 1950, 11096, 1019, 16, 3]}, "items": [{"id": "p_2560", "content": "Elastosis perforans serpiginosa [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15084, 2475, 16946, 2075, 27453, 1950, 11096, 1019, 3, 3]}]}
{"query": {"id": "q_2561", "content": "Wilson's disease [SEP]  which has been reported as a rare side effect in patients with Wilson's disease but not in patients with rheumatoid arthritis treated with peni", "tokenized_content": [2, 17711, 11, 61, 2573, 3, 2154, 2258, 2252, 2568, 1966, 43, 5844, 4159, 2495, 1922, 2132, 1956, 17711, 11, 61, 2573, 2308, 2084, 1922, 2132, 1956, 13053, 8884, 2868, 1956, 3]}, "items": [{"id": "p_2561", "content": "Hepatolenticular Degeneration [SEP] A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It i", "score": 1, "type": null, "tokenized_content": [2, 5746, 2456, 4905, 4588, 9174, 3, 43, 5844, 13027, 13992, 2573, 4378, 2007, 1920, 7860, 1927, 9541, 1922, 1920, 3068, 31, 3568, 31, 16678, 31, 1930, 2303, 7393, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2562", "content": "cardiac arrhythmias [SEP] Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.", "tokenized_content": [2, 4435, 16934, 3, 15894, 4158, 2840, 1930, 4435, 16934, 1922, 2132, 5962, 26545, 4195, 18, 3]}, "items": [{"id": "p_2562", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2563", "content": "phenothiazines [SEP] ife-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were recei", "tokenized_content": [2, 3037, 30354, 2613, 3, 2647, 1021, 17, 13281, 1922, 3628, 2679, 6303, 26545, 4195, 16, 3108, 3037, 30354, 2613, 2014, 12258, 13153, 17722, 18, 2876, 2501, 2132, 1985, 3169, 1033, 3]}, "items": [{"id": "p_2563", "content": "Phenothiazines [SEP] Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3037, 30354, 2613, 3, 4300, 3165, 17239, 4389, 1037, 17, 21, 16, 24, 17, 27225, 2053, 18, 2673, 1927, 3581, 2032, 3366, 3849, 18, 3]}]}
{"query": {"id": "q_2564", "content": "Mellaril [SEP] pressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ven", "tokenized_content": [2, 9072, 2205, 1024, 3, 3477, 2356, 18, 2876, 2501, 2132, 1985, 5962, 2980, 4195, 16, 9072, 2205, 1024, 12, 21591, 9532, 22030, 2912, 13, 6209, 1942, 1998, 5061, 1958, 3628, 3]}, "items": [{"id": "p_2564", "content": "Thioridazine [SEP] A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21591, 9532, 22030, 2912, 3, 43, 3037, 30354, 2053, 17581, 2251, 1922, 1920, 4280, 1927, 25511, 12278, 16, 2710, 7899, 18, 3]}]}
{"query": {"id": "q_2565", "content": "thioridazine [SEP]  Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachy", "tokenized_content": [2, 21591, 9532, 22030, 2912, 3, 2876, 2501, 2132, 1985, 5962, 2980, 4195, 16, 9072, 2205, 1024, 12, 21591, 9532, 22030, 2912, 13, 6209, 1942, 1998, 5061, 1958, 3628, 2919, 1927, 3]}, "items": [{"id": "p_2565", "content": "Thioridazine [SEP] A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21591, 9532, 22030, 2912, 3, 43, 3037, 30354, 2053, 17581, 2251, 1922, 1920, 4280, 1927, 25511, 12278, 16, 2710, 7899, 18, 3]}]}
{"query": {"id": "q_2566", "content": "ventricular tachycardia [SEP] ril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricula", "tokenized_content": [2, 6493, 17397, 3, 20886, 12, 21591, 9532, 22030, 2912, 13, 6209, 1942, 1998, 5061, 1958, 3628, 2919, 1927, 6493, 17397, 16, 2340, 1927, 2154, 1982, 11990, 1922, 43, 3259, 2476, 3]}, "items": [{"id": "p_2566", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_2567", "content": "Supraventricular tachycardia [SEP] lar tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). ", "tokenized_content": [2, 21038, 24722, 17397, 3, 6590, 17397, 16, 2340, 1927, 2154, 1982, 11990, 1922, 43, 3259, 2476, 4156, 10440, 18, 21038, 24722, 17397, 3530, 1922, 2340, 2774, 5962, 6625, 10119, 12, 3]}, "items": [{"id": "p_2567", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_2568", "content": "Thorazine [SEP] Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitripty", "tokenized_content": [2, 6625, 10119, 3, 21038, 24722, 17397, 3530, 1922, 2340, 2774, 5962, 6625, 10119, 12, 4891, 2216, 3368, 22030, 2912, 13, 18, 16959, 3145, 1024, 12, 3990, 1997, 14302, 26561, 13, 3]}, "items": [{"id": "p_2568", "content": "Chlorpromazine [SEP] The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are", "score": 1, "type": null, "tokenized_content": [2, 4891, 2216, 3368, 22030, 2912, 3, 1920, 29183, 3037, 30354, 2053, 17581, 2838, 18, 3189, 1920, 2303, 4195, 1922, 2052, 2921, 4891, 2216, 3368, 22030, 2912, 11, 61, 17581, 7728, 2032, 3]}]}
{"query": {"id": "q_2569", "content": "chlorpromazine [SEP] cular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produ", "tokenized_content": [2, 4891, 2216, 3368, 22030, 2912, 3, 6710, 1933, 17397, 3530, 1922, 2340, 2774, 5962, 6625, 10119, 12, 4891, 2216, 3368, 22030, 2912, 13, 18, 16959, 3145, 1024, 12, 3990, 1997, 3]}, "items": [{"id": "p_2569", "content": "Chlorpromazine [SEP] The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are", "score": 1, "type": null, "tokenized_content": [2, 4891, 2216, 3368, 22030, 2912, 3, 1920, 29183, 3037, 30354, 2053, 17581, 2838, 18, 3189, 1920, 2303, 4195, 1922, 2052, 2921, 4891, 2216, 3368, 22030, 2912, 11, 61, 17581, 7728, 2032, 3]}]}
{"query": {"id": "q_2570", "content": "Aventyl [SEP]  developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left b", "tokenized_content": [2, 16959, 3145, 1024, 3, 3530, 1922, 2340, 2774, 5962, 6625, 10119, 12, 4891, 2216, 3368, 22030, 2912, 13, 18, 16959, 3145, 1024, 12, 3990, 1997, 14302, 26561, 13, 1930, 2349, 3]}, "items": [{"id": "p_2570", "content": "Nortriptyline [SEP] A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia", "score": 1, "type": null, "tokenized_content": [2, 3990, 1997, 14302, 26561, 3, 43, 9483, 1927, 15665, 1997, 14302, 26561, 1988, 1977, 2222, 2251, 1966, 1925, 11248, 2320, 5899, 18, 3990, 1997, 14302, 26561, 1977, 2251, 1922, 3044, 4621, 16, 10612, 30338, 6026, 3]}]}
{"query": {"id": "q_2571", "content": "nortriptyline [SEP] d in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch bl", "tokenized_content": [2, 3990, 1997, 14302, 26561, 3, 46, 1922, 2340, 2774, 5962, 6625, 10119, 12, 4891, 2216, 3368, 22030, 2912, 13, 18, 16959, 3145, 1024, 12, 3990, 1997, 14302, 26561, 13, 1930, 3]}, "items": [{"id": "p_2571", "content": "Nortriptyline [SEP] A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia", "score": 1, "type": null, "tokenized_content": [2, 3990, 1997, 14302, 26561, 3, 43, 9483, 1927, 15665, 1997, 14302, 26561, 1988, 1977, 2222, 2251, 1966, 1925, 11248, 2320, 5899, 18, 3990, 1997, 14302, 26561, 1977, 2251, 1922, 3044, 4621, 16, 10612, 30338, 6026, 3]}]}
{"query": {"id": "q_2572", "content": "Elavil [SEP] ceiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 ", "tokenized_content": [2, 2349, 9188, 1024, 3, 5827, 3647, 6625, 10119, 12, 4891, 2216, 3368, 22030, 2912, 13, 18, 16959, 3145, 1024, 12, 3990, 1997, 14302, 26561, 13, 1930, 2349, 9188, 1024, 12, 3]}, "items": [{"id": "p_2572", "content": "Amitriptyline [SEP] Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and", "score": 1, "type": null, "tokenized_content": [2, 15665, 1997, 14302, 26561, 3, 12258, 13153, 14183, 1956, 5851, 12074, 12745, 1930, 28514, 3879, 18, 2176, 5107, 1942, 4625, 1920, 1964, 17, 5047, 1927, 16436, 1930, 3]}]}
{"query": {"id": "q_2573", "content": "amitriptyline [SEP] Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman.", "tokenized_content": [2, 15665, 1997, 14302, 26561, 3, 6625, 10119, 12, 4891, 2216, 3368, 22030, 2912, 13, 18, 16959, 3145, 1024, 12, 3990, 1997, 14302, 26561, 13, 1930, 2349, 9188, 1024, 12, 15665, 3]}, "items": [{"id": "p_2573", "content": "Amitriptyline [SEP] Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and", "score": 1, "type": null, "tokenized_content": [2, 15665, 1997, 14302, 26561, 3, 12258, 13153, 14183, 1956, 5851, 12074, 12745, 1930, 28514, 3879, 18, 2176, 5107, 1942, 4625, 1920, 1964, 17, 5047, 1927, 16436, 1930, 3]}]}
{"query": {"id": "q_2574", "content": "left bundle branch block [SEP] ventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnor", "tokenized_content": [2, 3506, 14142, 6089, 3367, 3, 14654, 2199, 12, 3990, 1997, 14302, 26561, 13, 1930, 2349, 9188, 1024, 12, 15665, 1997, 14302, 26561, 13, 2362, 4152, 3506, 14142, 6089, 3367, 1922, 3]}, "items": [{"id": "p_2574", "content": "Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU", "score": 1, "type": null, "tokenized_content": [2, 14142, 17, 6089, 3367, 3, 43, 2386, 1927, 4003, 3367, 1922, 2154, 1920, 8287, 4177, 1927, 4003, 21008, 1977, 20291, 2019, 3108, 2340, 1927, 1920, 11208, 1927, 3168, 3]}]}
{"query": {"id": "q_2575", "content": "ventricular arrhythmias [SEP] c T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to dir", "tokenized_content": [2, 6493, 16934, 3, 45, 62, 1930, 63, 5913, 6754, 1985, 2481, 1922, 2501, 2132, 18, 1920, 6493, 16934, 10711, 1942, 7307, 4183, 1927, 19567, 1930, 1942, 17393, 3]}, "items": [{"id": "p_2575", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2576", "content": "lidocaine [SEP] tricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was re", "tokenized_content": [2, 19567, 3, 12258, 2168, 16934, 10711, 1942, 7307, 4183, 1927, 19567, 1930, 1942, 3083, 3214, 10219, 7418, 31, 6493, 17248, 1982, 1964, 3]}, "items": [{"id": "p_2576", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_2577", "content": "propranolol [SEP] as required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias g", "tokenized_content": [2, 21395, 3, 1966, 3414, 1922, 2673, 12421, 1930, 7307, 4183, 1927, 21395, 4252, 1956, 6493, 17248, 1922, 2340, 18, 1920, 12762, 9771, 18858, 10245, 15519, 49, 3]}, "items": [{"id": "p_2577", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2578", "content": "tachyarrhythmias [SEP] ion of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the ", "tokenized_content": [2, 12762, 9771, 18858, 10245, 15519, 3, 4755, 1927, 21395, 4252, 1956, 6493, 17248, 1922, 2340, 18, 1920, 12762, 9771, 18858, 10245, 15519, 4933, 23981, 1919, 2651, 3427, 3967, 2256, 4183, 3]}, "items": [{"id": "p_2578", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_2579", "content": "heart disease [SEP] ere 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients w", "tokenized_content": [2, 4003, 2573, 3, 22561, 2761, 2739, 1927, 2632, 2014, 7237, 31, 2444, 2340, 5436, 2430, 25667, 1939, 4003, 2573, 18, 3044, 4435, 16934, 2032, 43, 2889, 7320, 1922, 2132, 65, 3]}, "items": [{"id": "p_2579", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_2580", "content": "cardiac arrhythmias [SEP] r younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who ar", "tokenized_content": [2, 4435, 16934, 3, 60, 7237, 31, 2444, 2340, 5436, 2430, 25667, 1939, 4003, 2573, 18, 3044, 4435, 16934, 2032, 43, 2889, 7320, 1922, 2132, 2979, 4003, 2573, 2746, 2245, 3]}, "items": [{"id": "p_2580", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2581", "content": "cardiac complications [SEP] prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressan", "tokenized_content": [2, 4435, 5021, 3, 6315, 2535, 3046, 1977, 3978, 1942, 8730, 1920, 2565, 1927, 4435, 5021, 1942, 2132, 5962, 3037, 30354, 2613, 2014, 12258, 13153, 11248, 1928, 3]}, "items": [{"id": "p_2581", "content": "Cardiac Complexes, Premature [SEP] A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atr", "score": 1, "type": null, "tokenized_content": [2, 4435, 5048, 16, 9839, 3, 43, 2210, 1927, 4435, 16934, 1922, 2154, 1920, 4435, 15465, 2032, 2084, 7796, 2019, 1920, 3132, 6952, 17075, 6267, 18, 2611, 3951, 2321, 6204, 3]}]}
{"query": {"id": "q_2582", "content": "benzodiazepines [SEP] Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain", "tokenized_content": [2, 26555, 3, 21292, 4195, 16, 26555, 1930, 30491, 18514, 3367, 7841, 1980, 1945, 17, 2719, 15924, 2223, 3490, 26482, 5297, 1922, 43, 3943, 3]}, "items": [{"id": "p_2582", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_2583", "content": "baclofen [SEP] Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.", "tokenized_content": [2, 30491, 18514, 3, 21292, 4195, 16, 26555, 1930, 30491, 18514, 3367, 7841, 1980, 1945, 17, 2719, 15924, 2223, 3490, 26482, 5297, 1922, 43, 3943, 1927, 2518, 18, 3]}, "items": [{"id": "p_2583", "content": "Baclofen [SEP] A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPAST", "score": 1, "type": null, "tokenized_content": [2, 30491, 18514, 3, 43, 7034, 17, 29093, 2687, 10533, 1988, 1977, 43, 2487, 7829, 1927, 7992, 17, 44, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3760, 19361, 2156, 3]}]}
{"query": {"id": "q_2584", "content": "muscimol [SEP] Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.", "tokenized_content": [2, 7841, 1980, 1945, 3, 21292, 4195, 16, 26555, 1930, 30491, 18514, 3367, 7841, 1980, 1945, 17, 2719, 15924, 2223, 3490, 26482, 5297, 1922, 43, 3943, 1927, 2518, 18, 3]}, "items": [{"id": "p_2584", "content": "Muscimol [SEP] A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a poten", "score": 1, "type": null, "tokenized_content": [2, 7841, 1980, 1945, 3, 43, 20919, 4911, 11414, 13642, 1952, 3937, 2037, 3038, 1927, 2150, 8150, 3857, 18, 2176, 1977, 2926, 2007, 22429, 1943, 1927, 6180, 7229, 19730, 2687, 18, 7841, 1980, 1945, 1977, 43, 2543, 1917, 3]}]}
{"query": {"id": "q_2585", "content": "myoclonic jerks [SEP] rgic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.", "tokenized_content": [2, 15924, 2223, 3490, 26482, 5297, 3, 9372, 1935, 4195, 16, 26555, 1930, 30491, 18514, 3367, 7841, 1980, 1945, 17, 2719, 15924, 2223, 3490, 26482, 5297, 1922, 43, 3943, 1927, 2518, 3]}, "items": [{"id": "p_2585", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_2586", "content": "muscimol [SEP] In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this re", "tokenized_content": [2, 7841, 1980, 1945, 3, 1922, 4005, 15412, 2518, 16, 7841, 1980, 1945, 4152, 15924, 2223, 3490, 26482, 5297, 18, 43, 23, 2786, 19, 3621, 12, 51, 18, 58, 18, 13, 3]}, "items": [{"id": "p_2586", "content": "Muscimol [SEP] A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a poten", "score": 1, "type": null, "tokenized_content": [2, 7841, 1980, 1945, 3, 43, 20919, 4911, 11414, 13642, 1952, 3937, 2037, 3038, 1927, 2150, 8150, 3857, 18, 2176, 1977, 2926, 2007, 22429, 1943, 1927, 6180, 7229, 19730, 2687, 18, 7841, 1980, 1945, 1977, 43, 2543, 1917, 3]}]}
{"query": {"id": "q_2587", "content": "myoclonic jerks [SEP] In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this response in all of the mice", "tokenized_content": [2, 15924, 2223, 3490, 26482, 5297, 3, 1922, 4005, 15412, 2518, 16, 7841, 1980, 1945, 4152, 15924, 2223, 3490, 26482, 5297, 18, 43, 23, 2786, 19, 3621, 12, 51, 18, 58, 3]}, "items": [{"id": "p_2587", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_2588", "content": "serotonin [SEP] er min was observed between 27 and 45 min. Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/", "tokenized_content": [2, 11153, 3, 2668, 2360, 1982, 2528, 2192, 3225, 1930, 3607, 2360, 18, 3605, 1920, 3068, 11153, 2428, 2007, 1920, 4183, 1927, 25, 17, 8275, 30298, 2688, 1928, 12, 3729, 17, 3]}, "items": [{"id": "p_2588", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_2589", "content": "5-hydroxytryptophan [SEP]  Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/kg) in combination with a peripheral decarboxylase i", "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 3605, 1920, 3068, 11153, 2428, 2007, 1920, 4183, 1927, 25, 17, 8275, 30298, 2688, 1928, 12, 3729, 17, 9608, 2786, 19, 3621, 13, 3]}, "items": [{"id": "p_2589", "content": "5-Hydroxytryptophan [SEP] The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.\n   ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 1920, 8426, 7897, 1922, 1920, 8132, 1927, 11153, 2037, 13489, 18, 2176, 1977, 2251, 1966, 1925, 29132, 1930, 14183, 18, 3]}]}
{"query": {"id": "q_2590", "content": "l-dopa [SEP] bition of the muscimol effect. However, in a similar experiment l-dopa (80-160 mg/kg) was without effect. In doses of 3-10 mg/kg, the ", "tokenized_content": [2, 54, 17, 19428, 3, 11996, 2001, 1927, 1920, 7841, 1980, 1945, 2495, 18, 2406, 16, 1922, 43, 2551, 3859, 54, 17, 19428, 12, 3729, 17, 9608, 2786, 19, 3621, 13, 3]}, "items": [{"id": "p_2590", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2591", "content": "MK-212 [SEP]  effect. In doses of 3-10 mg/kg, the serotonin receptor agonist MK-212 caused a dose-dependent blockade of the response of muscimol. O", "tokenized_content": [2, 10539, 17, 17251, 3, 2495, 18, 1922, 5312, 1927, 23, 17, 2119, 2786, 19, 3621, 16, 1920, 11153, 3148, 7829, 10539, 17, 17251, 4189, 43, 3253, 17, 3100, 9847, 1927, 3]}, "items": [{"id": "p_2591", "content": "MK 212 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10539, 17251, 3, 3]}]}
{"query": {"id": "q_2592", "content": "benzodiazepines [SEP] d a dose-dependent blockade of the response of muscimol. Of the benzodiazepines, clonazepam (0.1-0.3 mg/kg) was found to be several fold more p", "tokenized_content": [2, 26555, 3, 46, 43, 3253, 17, 3100, 9847, 1927, 1920, 2644, 1927, 7841, 1980, 1945, 18, 1927, 1920, 26555, 16, 6138, 28231, 12, 20, 18, 21, 17, 20, 18, 23, 3]}, "items": [{"id": "p_2592", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_2593", "content": "clonazepam [SEP] t blockade of the response of muscimol. Of the benzodiazepines, clonazepam (0.1-0.3 mg/kg) was found to be several fold more potent than d", "tokenized_content": [2, 6138, 28231, 3, 62, 9847, 1927, 1920, 2644, 1927, 7841, 1980, 1945, 18, 1927, 1920, 26555, 16, 6138, 28231, 12, 20, 18, 21, 17, 20, 18, 23, 2786, 19, 3621, 3]}, "items": [{"id": "p_2593", "content": "Clonazepam [SEP] An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absenc", "score": 1, "type": null, "tokenized_content": [2, 6138, 28231, 3, 1925, 26572, 2031, 2251, 1958, 2980, 3584, 1927, 10060, 16, 2710, 15924, 24970, 2014, 2019, 3490, 10060, 16, 27462, 1961, 9741, 16, 1930, 2872, 2135, 3]}]}
{"query": {"id": "q_2594", "content": "diazepam [SEP] m (0.1-0.3 mg/kg) was found to be several fold more potent than diazepam (0.3-3 mg/kg) in blocking the myoclonic jerks. While (-)-baclof", "tokenized_content": [2, 26079, 3, 55, 12, 20, 18, 21, 17, 20, 18, 23, 2786, 19, 3621, 13, 1982, 2435, 1942, 1998, 2980, 3728, 2253, 6828, 2254, 26079, 12, 20, 18, 23, 17, 3]}, "items": [{"id": "p_2594", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_2595", "content": "baclofen [SEP] azepam (0.3-3 mg/kg) in blocking the myoclonic jerks. While (-)-baclofen (1-3 mg/kg) proved to be an effective antagonist of muscimol, i", "tokenized_content": [2, 30491, 18514, 3, 6352, 2128, 1976, 12, 20, 18, 23, 17, 23, 2786, 19, 3621, 13, 1922, 7472, 1920, 15924, 2223, 3490, 26482, 5297, 18, 2679, 12, 17, 13, 17, 3]}, "items": [{"id": "p_2595", "content": "Baclofen [SEP] A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPAST", "score": 1, "type": null, "tokenized_content": [2, 30491, 18514, 3, 43, 7034, 17, 29093, 2687, 10533, 1988, 1977, 43, 2487, 7829, 1927, 7992, 17, 44, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3760, 19361, 2156, 3]}]}
{"query": {"id": "q_2596", "content": "5-HTP [SEP] er (5-20 mg/kg) lacked this property. Considering the fact that 5-HTP and the benzodiazepines have been found to be beneficial in the", "tokenized_content": [2, 25, 17, 5334, 1034, 3, 2668, 12, 25, 17, 2036, 2786, 19, 3621, 13, 15115, 2052, 9675, 18, 6300, 1920, 2371, 1988, 25, 17, 5334, 1034, 1930, 1920, 26555, 2162, 3]}, "items": [{"id": "p_2596", "content": "5-Hydroxytryptophan [SEP] The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.\n   ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 1920, 8426, 7897, 1922, 1920, 8132, 1927, 11153, 2037, 13489, 18, 2176, 1977, 2251, 1966, 1925, 29132, 1930, 14183, 18, 3]}]}
{"query": {"id": "q_2597", "content": "myoclonus [SEP]  have been found to be beneficial in the management of clinical myoclonus, the muscimol-induced myoclonus seems to be a satisfactory anim", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 2162, 2252, 2435, 1942, 1998, 6928, 1922, 1920, 4280, 1927, 2535, 15924, 2223, 1916, 1957, 16, 1920, 7841, 1980, 1945, 17, 2719, 15924, 2223, 1916, 3]}, "items": [{"id": "p_2597", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_2598", "content": "Hyperglycemic [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.", "tokenized_content": [2, 30473, 3, 30473, 2687, 3153, 22337, 1930, 3539, 1922, 3364, 1933, 3355, 17, 12471, 1936, 4741, 18, 3]}, "items": [{"id": "p_2598", "content": "Hyperglycemia [SEP] Abnormally high BLOOD GLUCOSE level.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14022, 3, 20756, 2149, 2877, 3817, 2237, 18, 3]}]}
{"query": {"id": "q_2599", "content": "acidotic [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.", "tokenized_content": [2, 2687, 3153, 3, 30473, 2687, 3153, 22337, 1930, 3539, 1922, 3364, 1933, 3355, 17, 12471, 1936, 4741, 18, 3]}, "items": [{"id": "p_2599", "content": "Acidosis, Lactic [SEP] Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in associa", "score": 1, "type": null, "tokenized_content": [2, 19051, 16, 16562, 3, 19051, 4189, 2007, 4858, 1927, 16562, 2687, 2253, 6221, 2254, 2176, 2112, 1998, 19654, 18, 2176, 2278, 4704, 12753, 2014, 1922, 2293, 1019, 3]}]}
{"query": {"id": "q_2600", "content": "coma [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.", "tokenized_content": [2, 22337, 3, 30473, 2687, 3153, 22337, 1930, 3539, 1922, 3364, 1933, 3355, 17, 12471, 1936, 4741, 18, 3]}, "items": [{"id": "p_2600", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_2601", "content": "Kearns-Sayre syndrome [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.", "tokenized_content": [2, 3364, 1933, 3355, 17, 12471, 1936, 4741, 3, 30473, 2687, 3153, 22337, 1930, 3539, 1922, 3364, 1933, 3355, 17, 12471, 1936, 4741, 18, 3]}, "items": [{"id": "p_2601", "content": "Kearns-Sayre Syndrome [SEP] A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) ", "score": 1, "type": null, "tokenized_content": [2, 3364, 1933, 3355, 17, 12471, 1936, 4741, 3, 43, 4596, 4770, 29931, 1920, 21845, 1927, 3724, 7529, 5771, 14554, 4279, 11966, 16, 14141, 12, 8291, 16038, 13, 3]}]}
{"query": {"id": "q_2602", "content": "Kearns-Sayre syndrome [SEP] cal and metabolic findings in two young boys with long-standing Kearns-Sayre syndrome. Following short exposure to oral prednisone, both boys develop", "tokenized_content": [2, 3364, 1933, 3355, 17, 12471, 1936, 4741, 3, 2570, 1930, 4487, 3056, 1922, 2288, 4201, 10294, 1956, 2815, 17, 11982, 3364, 1933, 3355, 17, 12471, 1936, 4741, 18, 2894, 3662, 3]}, "items": [{"id": "p_2602", "content": "Kearns-Sayre Syndrome [SEP] A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) ", "score": 1, "type": null, "tokenized_content": [2, 3364, 1933, 3355, 17, 12471, 1936, 4741, 3, 43, 4596, 4770, 29931, 1920, 21845, 1927, 3724, 7529, 5771, 14554, 4279, 11966, 16, 14141, 12, 8291, 16038, 13, 3]}]}
{"query": {"id": "q_2603", "content": "prednisone [SEP] tanding Kearns-Sayre syndrome. Following short exposure to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsi", "tokenized_content": [2, 20405, 3, 10434, 2117, 3364, 1933, 3355, 17, 12471, 1936, 4741, 18, 2894, 3662, 3395, 1942, 4726, 20405, 16, 2321, 10294, 3530, 8381, 2419, 1012, 16, 3605, 5714, 11873, 15253, 3]}, "items": [{"id": "p_2603", "content": "Prednisone [SEP] A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in t", "score": 1, "type": null, "tokenized_content": [2, 20405, 3, 43, 6830, 2246, 17, 3769, 14469, 3595, 2037, 18964, 8142, 1021, 18, 2176, 1977, 12186, 22937, 1930, 9076, 1942, 22025, 1922, 62, 3]}]}
{"query": {"id": "q_2604", "content": "lethargy [SEP] ollowing short exposure to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. B", "tokenized_content": [2, 8381, 2419, 1012, 3, 2865, 16496, 1941, 3662, 3395, 1942, 4726, 20405, 16, 2321, 10294, 3530, 8381, 2419, 1012, 16, 3605, 5714, 11873, 15253, 1972, 16, 19534, 5689, 2126, 16, 3]}, "items": [{"id": "p_2604", "content": "Lethargy [SEP] A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simp", "score": 1, "type": null, "tokenized_content": [2, 8381, 2419, 1012, 3, 43, 3335, 3360, 1927, 25387, 6121, 6150, 2971, 16, 6069, 5427, 16, 2014, 18191, 10008, 2013, 16, 1956, 3301, 16661, 1919, 16, 1930, 4537, 8791, 2587, 2287, 1930, 12979, 2328, 1034, 3]}]}
{"query": {"id": "q_2605", "content": "somnolence [SEP] re to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the em", "tokenized_content": [2, 5714, 11873, 15253, 1972, 3, 1964, 1942, 4726, 20405, 16, 2321, 10294, 3530, 8381, 2419, 1012, 16, 3605, 5714, 11873, 15253, 1972, 16, 19534, 5689, 2126, 16, 11769, 17378, 16, 3]}, "items": [{"id": "p_2605", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_2606", "content": "polydipsia [SEP] rednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the emergency room", "tokenized_content": [2, 19534, 5689, 2126, 3, 2312, 11110, 2290, 16, 2321, 10294, 3530, 8381, 2419, 1012, 16, 3605, 5714, 11873, 15253, 1972, 16, 19534, 5689, 2126, 16, 11769, 17378, 16, 1930, 4286, 3]}, "items": [{"id": "p_2606", "content": "Polydipsia [SEP] Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES", "score": 1, "type": null, "tokenized_content": [2, 19534, 5689, 2126, 3, 9122, 4053, 2156, 16687, 2007, 9122, 5466, 5240, 18, 2176, 1977, 6293, 1927, 3086, 3902, 2427, 1966, 4032, 9695, 31, 4032, 3]}]}
{"query": {"id": "q_2607", "content": "polyphagia [SEP] oth boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the emergency room with profou", "tokenized_content": [2, 11769, 17378, 3, 7608, 1023, 10294, 3530, 8381, 2419, 1012, 16, 3605, 5714, 11873, 15253, 1972, 16, 19534, 5689, 2126, 16, 11769, 17378, 16, 1930, 4286, 8754, 18, 2321, 3549, 3]}, "items": [{"id": "p_2607", "content": "Hyperphagia [SEP] Ingestion of a greater than optimal quantity of food.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 4151, 11966, 3, 14195, 1927, 43, 3430, 2254, 5419, 9988, 1927, 3959, 18, 3]}]}
{"query": {"id": "q_2608", "content": "polyuria [SEP] ed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the emergency room with profound coma, hypot", "tokenized_content": [2, 4286, 8754, 3, 3347, 8381, 2419, 1012, 16, 3605, 5714, 11873, 15253, 1972, 16, 19534, 5689, 2126, 16, 11769, 17378, 16, 1930, 4286, 8754, 18, 2321, 3549, 1922, 1920, 7877, 3]}, "items": [{"id": "p_2608", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_2609", "content": "coma [SEP] nd polyuria. Both presented in the emergency room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic la", "tokenized_content": [2, 22337, 3, 8026, 4286, 8754, 18, 2321, 3549, 1922, 1920, 7877, 4921, 1956, 11098, 22337, 16, 16453, 16, 4010, 14022, 16, 1930, 19051, 18, 2447, 18540, 3153, 5114, 3]}, "items": [{"id": "p_2609", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_2610", "content": "hypotension [SEP] yuria. Both presented in the emergency room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis", "tokenized_content": [2, 16453, 3, 15971, 3027, 1019, 18, 2321, 3549, 1922, 1920, 7877, 4921, 1956, 11098, 22337, 16, 16453, 16, 4010, 14022, 16, 1930, 19051, 18, 2447, 18540, 3153, 16562, 19051, 3]}, "items": [{"id": "p_2610", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2611", "content": "hyperglycemia [SEP] d in the emergency room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis was present in one an", "tokenized_content": [2, 14022, 3, 46, 1922, 1920, 7877, 4921, 1956, 11098, 22337, 16, 16453, 16, 4010, 14022, 16, 1930, 19051, 18, 2447, 18540, 3153, 16562, 19051, 1982, 2481, 1922, 2340, 1925, 3]}, "items": [{"id": "p_2611", "content": "Hyperglycemia [SEP] Abnormally high BLOOD GLUCOSE level.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14022, 3, 20756, 2149, 2877, 3817, 2237, 18, 3]}]}
{"query": {"id": "q_2612", "content": "acidosis [SEP] room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis was present in one and ketosis with", "tokenized_content": [2, 19051, 3, 4921, 1956, 11098, 22337, 16, 16453, 16, 4010, 14022, 16, 1930, 19051, 18, 2447, 18540, 3153, 16562, 19051, 1982, 2481, 1922, 2340, 1930, 21471, 8362, 1956, 3]}, "items": [{"id": "p_2612", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_2613", "content": "lactic acidosis [SEP] ma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis was present in one and ketosis without a known serum lactate le", "tokenized_content": [2, 16562, 19051, 3, 2488, 16, 16453, 16, 4010, 14022, 16, 1930, 19051, 18, 2447, 18540, 3153, 16562, 19051, 1982, 2481, 1922, 2340, 1930, 21471, 8362, 2979, 43, 3171, 3256, 9456, 3]}, "items": [{"id": "p_2613", "content": "Acidosis, Lactic [SEP] Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in associa", "score": 1, "type": null, "tokenized_content": [2, 19051, 16, 16562, 3, 19051, 4189, 2007, 4858, 1927, 16562, 2687, 2253, 6221, 2254, 2176, 2112, 1998, 19654, 18, 2176, 2278, 4704, 12753, 2014, 1922, 2293, 1019, 3]}]}
{"query": {"id": "q_2614", "content": "ketosis [SEP] and acidosis. Nonketotic lactic acidosis was present in one and ketosis without a known serum lactate level was present in the other. R", "tokenized_content": [2, 21471, 8362, 3, 1930, 19051, 18, 2447, 18540, 3153, 16562, 19051, 1982, 2481, 1922, 2340, 1930, 21471, 8362, 2979, 43, 3171, 3256, 9456, 2237, 1982, 2481, 1922, 1920, 2303, 18, 3]}, "items": [{"id": "p_2614", "content": "Ketosis [SEP] A condition characterized by an abnormally elevated concentration of KETONE BODIES in the blood (acetonemia) or urine (acetonuri", "score": 1, "type": null, "tokenized_content": [2, 21471, 8362, 3, 43, 2625, 4378, 2007, 1925, 20756, 4664, 3110, 1927, 21876, 8322, 1922, 1920, 2877, 12, 14123, 6026, 13, 2014, 6960, 12, 4118, 1916, 18330, 3]}]}
{"query": {"id": "q_2615", "content": "lactate [SEP] c acidosis was present in one and ketosis without a known serum lactate level was present in the other. Respiratory failure rapidly ens", "tokenized_content": [2, 9456, 3, 45, 19051, 1982, 2481, 1922, 2340, 1930, 21471, 8362, 2979, 43, 3171, 3256, 9456, 2237, 1982, 2481, 1922, 1920, 2303, 18, 5481, 4574, 6221, 4847, 3]}, "items": [{"id": "p_2615", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_2616", "content": "Respiratory failure [SEP] s without a known serum lactate level was present in the other. Respiratory failure rapidly ensued and both patients expired in spite of efforts at", "tokenized_content": [2, 5481, 4574, 3, 61, 2979, 43, 3171, 3256, 9456, 2237, 1982, 2481, 1922, 1920, 2303, 18, 5481, 4574, 6221, 4847, 6436, 1930, 2321, 2132, 2887, 3030, 1922, 14168, 1927, 6905, 3]}, "items": [{"id": "p_2616", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_2617", "content": "crocin [SEP] Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease i", "tokenized_content": [2, 9442, 3665, 3, 2564, 1927, 3500, 14423, 1927, 9442, 6973, 15036, 1020, 1957, 54, 18, 16, 9442, 3665, 1990, 25518, 11778, 17, 2719, 2322, 1927, 13088, 9116, 11, 61, 2573, 3]}, "items": [{"id": "p_2617", "content": "crocin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9442, 3665, 3, 3]}]}
{"query": {"id": "q_2618", "content": "streptozocin [SEP] Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats.", "tokenized_content": [2, 25518, 11778, 3, 2564, 1927, 3500, 14423, 1927, 9442, 6973, 15036, 1020, 1957, 54, 18, 16, 9442, 3665, 1990, 25518, 11778, 17, 2719, 2322, 1927, 13088, 9116, 11, 61, 2573, 3]}, "items": [{"id": "p_2618", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_2619", "content": "Alzheimer's disease [SEP] us sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats.", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 2022, 15036, 1020, 1957, 54, 18, 16, 9442, 3665, 1990, 25518, 11778, 17, 2719, 2322, 1927, 13088, 9116, 11, 61, 2573, 1922, 4005, 3615, 18, 3]}, "items": [{"id": "p_2619", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_2620", "content": "carotenoids [SEP] BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L", "tokenized_content": [2, 22359, 3, 3872, 30, 1920, 5668, 1927, 3224, 17, 6622, 22359, 16, 9442, 3665, 1036, 16, 1966, 1920, 2730, 1930, 3500, 4178, 1927, 9442, 6973, 15036, 1020, 1957, 54, 3]}, "items": [{"id": "p_2620", "content": "Carotenoids [SEP] The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are a", "score": 1, "type": null, "tokenized_content": [2, 22359, 3, 1920, 3335, 9533, 1958, 43, 2210, 1927, 3777, 17, 6622, 23756, 2435, 1922, 4524, 16, 7463, 16, 1930, 6998, 1012, 14206, 16, 1930, 7463, 12953, 18, 2611, 2032, 43, 3]}]}
{"query": {"id": "q_2621", "content": "crocins [SEP] BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extract", "tokenized_content": [2, 9442, 3665, 1036, 3, 3872, 30, 1920, 5668, 1927, 3224, 17, 6622, 22359, 16, 9442, 3665, 1036, 16, 1966, 1920, 2730, 1930, 3500, 4178, 1927, 9442, 6973, 15036, 1020, 1957, 3]}, "items": [{"id": "p_2621", "content": "crocin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9442, 3665, 3, 3]}]}
{"query": {"id": "q_2622", "content": "Alzheimer's disease [SEP] oposed. In the present study, the effect of crocins on sporadic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in ", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 2494, 10350, 18, 1922, 1920, 2481, 2161, 16, 1920, 2495, 1927, 9442, 3665, 1036, 1990, 13088, 9116, 11, 61, 2573, 2719, 2007, 19343, 18474, 24722, 3]}, "items": [{"id": "p_2622", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_2623", "content": "streptozocin [SEP] ic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. METHODS: Male adult Wistar", "tokenized_content": [2, 25518, 11778, 3, 3996, 9116, 11, 61, 2573, 2719, 2007, 19343, 18474, 24722, 12, 27191, 13, 25518, 11778, 12, 17632, 13, 1922, 4005, 3615, 1982, 3845, 18, 2860, 30, 4005, 3]}, "items": [{"id": "p_2623", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_2624", "content": "STZ [SEP]  disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. METHODS: Male adult Wistar rats", "tokenized_content": [2, 17632, 3, 2573, 2719, 2007, 19343, 18474, 24722, 12, 27191, 13, 25518, 11778, 12, 17632, 13, 1922, 4005, 3615, 1982, 3845, 18, 2860, 30, 4005, 4160, 15668, 3615, 3]}, "items": [{"id": "p_2624", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_2625", "content": "crocin [SEP] BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extrac", "tokenized_content": [2, 9442, 3665, 3, 3872, 30, 1920, 5668, 1927, 3224, 17, 6622, 22359, 16, 9442, 3665, 1036, 16, 1966, 1920, 2730, 1930, 3500, 4178, 1927, 9442, 6973, 15036, 1020, 1957, 54, 3]}, "items": [{"id": "p_2625", "content": "crocin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9442, 3665, 3, 3]}]}
{"query": {"id": "q_2626", "content": "memory impairment [SEP]  the mentioned dose could significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. CONCLU", "tokenized_content": [2, 4525, 6159, 3, 1920, 6996, 3253, 2578, 2567, 8060, 4809, 1930, 4525, 6159, 1922, 2868, 17632, 17, 5624, 2210, 1922, 9832, 11700, 2648, 18, 3008, 1032, 3]}, "items": [{"id": "p_2626", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_2627", "content": "cognitive deficits [SEP] rate the effectiveness of crocin (30 mg/kg) in antagonizing the cognitive deficits caused by STZ-icv in rats and its potential in the treatment of", "tokenized_content": [2, 4328, 7961, 3, 2769, 1920, 6001, 1927, 9442, 3665, 12, 2627, 2786, 19, 3621, 13, 1922, 5605, 3903, 1920, 4328, 7961, 4189, 2007, 17632, 17, 27191, 1922, 3615, 1930, 2496, 3]}, "items": [{"id": "p_2627", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_2628", "content": "neurodegenerative diseases [SEP] caused by STZ-icv in rats and its potential in the treatment of neurodegenerative diseases such as Alzheimer's disease.", "tokenized_content": [2, 11128, 3902, 3, 4189, 2007, 17632, 17, 27191, 1922, 3615, 1930, 2496, 2889, 1922, 1920, 2311, 1927, 11128, 3902, 2427, 1966, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2628", "content": "Neurodegenerative Diseases [SEP] Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often ", "score": 1, "type": null, "tokenized_content": [2, 11128, 3902, 3, 16321, 1930, 13088, 2961, 2154, 2032, 4378, 2007, 7529, 7580, 2433, 5273, 18, 2144, 4414, 2032, 3868, 3]}]}
{"query": {"id": "q_2629", "content": "dermatitis [SEP] Rosaceiform dermatitis associated with topical tacrolimus treatment.", "tokenized_content": [2, 18006, 3, 22424, 1972, 6154, 18006, 2458, 1956, 12259, 21801, 2311, 18, 3]}, "items": [{"id": "p_2629", "content": "Dermatitis [SEP] Any inflammation of the skin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18006, 3, 2967, 4531, 1927, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_2630", "content": "tacrolimus [SEP] Rosaceiform dermatitis associated with topical tacrolimus treatment.", "tokenized_content": [2, 21801, 3, 22424, 1972, 6154, 18006, 2458, 1956, 12259, 21801, 2311, 18, 3]}, "items": [{"id": "p_2630", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2631", "content": "rosacea [SEP] We describe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ", "tokenized_content": [2, 22424, 1972, 1019, 3, 2038, 5993, 10388, 23, 2132, 2746, 3530, 22424, 1972, 1019, 17, 3189, 18006, 25655, 1036, 2679, 2193, 20, 18, 5167, 9, 2014, 20, 18, 21, 9, 3]}, "items": [{"id": "p_2631", "content": "Rosacea [SEP] A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is ch", "score": 1, "type": null, "tokenized_content": [2, 22424, 1972, 1019, 3, 43, 11276, 4770, 5985, 1927, 19182, 2569, 1927, 1920, 4101, 3131, 1927, 1920, 6171, 16, 2427, 1966, 9023, 10611, 31, 10003, 2819, 31, 16427, 31, 1930, 6790, 18, 2176, 1977, 2016, 3]}]}
{"query": {"id": "q_2632", "content": "dermatitis [SEP] We describe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for fac", "tokenized_content": [2, 18006, 3, 2038, 5993, 10388, 23, 2132, 2746, 3530, 22424, 1972, 1019, 17, 3189, 18006, 25655, 1036, 2679, 2193, 20, 18, 5167, 9, 2014, 20, 18, 21, 9, 21801, 25166, 3]}, "items": [{"id": "p_2632", "content": "Dermatitis [SEP] Any inflammation of the skin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18006, 3, 2967, 4531, 1927, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_2633", "content": "eruptions [SEP] escribe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for facial dermat", "tokenized_content": [2, 25655, 1036, 3, 14382, 3027, 5873, 10388, 23, 2132, 2746, 3530, 22424, 1972, 1019, 17, 3189, 18006, 25655, 1036, 2679, 2193, 20, 18, 5167, 9, 2014, 20, 18, 21, 9, 3]}, "items": [{"id": "p_2633", "content": "Drug Eruptions [SEP] Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morpho", "score": 1, "type": null, "tokenized_content": [2, 2838, 25655, 1036, 3, 5246, 11276, 5298, 4189, 2007, 14195, 16, 20301, 2485, 16, 2014, 3076, 4722, 1927, 43, 2838, 18, 2144, 2278, 10336, 3425, 3901, 1037, 3]}]}
{"query": {"id": "q_2634", "content": "tacrolimus [SEP] ped rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for facial dermatitis. Skin biopsy specimens showed te", "tokenized_content": [2, 21801, 3, 5296, 22424, 1972, 1019, 17, 3189, 18006, 25655, 1036, 2679, 2193, 20, 18, 5167, 9, 2014, 20, 18, 21, 9, 21801, 25166, 4905, 2017, 1958, 9567, 18006, 18, 3]}, "items": [{"id": "p_2634", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2635", "content": "facial dermatitis [SEP] tis eruptions while using 0.03% or 0.1% tacrolimus ointment for facial dermatitis. Skin biopsy specimens showed telangiectasia and noncaseating e", "tokenized_content": [2, 9567, 18006, 3, 30152, 25655, 1036, 2679, 2193, 20, 18, 5167, 9, 2014, 20, 18, 21, 9, 21801, 25166, 4905, 2017, 1958, 9567, 18006, 18, 4407, 6831, 5864, 2594, 30512, 3]}, "items": [{"id": "p_2635", "content": "Facial Dermatoses [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9567, 13467, 12278, 3, 3]}]}
{"query": {"id": "q_2636", "content": "telangiectasia [SEP] us ointment for facial dermatitis. Skin biopsy specimens showed telangiectasia and noncaseating epithelioid granulomatous tissue formation in ", "tokenized_content": [2, 30512, 6646, 3, 2022, 25166, 4905, 2017, 1958, 9567, 18006, 18, 4407, 6831, 5864, 2594, 30512, 6646, 1930, 9341, 2051, 2287, 30001, 2642, 26676, 2960, 3337, 1922, 3]}, "items": [{"id": "p_2636", "content": "Telangiectasis [SEP] Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most common", "score": 1, "type": null, "tokenized_content": [2, 30512, 3932, 3, 11047, 16470, 1927, 21604, 2877, 7208, 12, 16973, 31, 24332, 31, 8102, 3275, 13, 11124, 2858, 8083, 2312, 4518, 16, 2501, 3059, 3]}]}
{"query": {"id": "q_2637", "content": "pimecrolimus [SEP] ontinuous topical use of immunomodulators such as tacrolimus or pimecrolimus should be regarded as a potential cause of rosaceiform dermatit", "tokenized_content": [2, 17019, 1940, 16487, 3, 9056, 1921, 10358, 12259, 2485, 1927, 15345, 20219, 2427, 1966, 21801, 2014, 17019, 1940, 16487, 3066, 1998, 11067, 1966, 43, 2889, 3936, 1927, 22424, 1972, 6154, 3]}, "items": [{"id": "p_2637", "content": "pimecrolimus [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17019, 1940, 16487, 3, 3]}]}
{"query": {"id": "q_2638", "content": "Tacrine [SEP] el of colloidal drug delivery system, able to trespass the BBB. Tacrine, administered in LiCl pre-treated rats, induces electrocorticog", "tokenized_content": [2, 9214, 5773, 3, 2349, 1927, 20205, 2838, 4868, 2433, 16, 4236, 1942, 2171, 3508, 2331, 1920, 12734, 18, 9214, 5773, 16, 5254, 1922, 27347, 2097, 17, 2868, 3615, 16, 6387, 3]}, "items": [{"id": "p_2638", "content": "Tacrine [SEP] A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxant", "score": 1, "type": null, "tokenized_content": [2, 9214, 5773, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 17553, 1920, 2877, 17, 3068, 7104, 18, 9214, 5773, 2258, 2252, 2251, 1942, 5836, 1920, 2564, 1927, 3760, 7327, 2031, 3]}]}
{"query": {"id": "q_2639", "content": "LiCl [SEP] very system, able to trespass the BBB. Tacrine, administered in LiCl pre-treated rats, induces electrocorticographic seizures and de", "tokenized_content": [2, 27347, 3, 3345, 2433, 16, 4236, 1942, 2171, 3508, 2331, 1920, 12734, 18, 9214, 5773, 16, 5254, 1922, 27347, 2097, 17, 2868, 3615, 16, 6387, 13142, 5994, 4158, 10060, 1930, 3]}, "items": [{"id": "p_2639", "content": "Lithium Chloride [SEP] A salt of lithium that has been used experimentally as an immunomodulator.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14330, 9140, 3, 43, 7012, 1927, 14330, 1988, 2258, 2252, 2251, 9568, 1966, 1925, 15345, 13505, 18, 3]}]}
{"query": {"id": "q_2640", "content": "seizures [SEP] istered in LiCl pre-treated rats, induces electrocorticographic seizures and delayed hippocampal damage. The toxic effects of tacrine-lo", "tokenized_content": [2, 10060, 3, 1977, 3188, 1922, 27347, 2097, 17, 2868, 3615, 16, 6387, 13142, 5994, 4158, 10060, 1930, 7083, 7636, 4293, 18, 1920, 6161, 2564, 1927, 9214, 5773, 17, 3004, 3]}, "items": [{"id": "p_2640", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2641", "content": "hippocampal damage [SEP] reated rats, induces electrocorticographic seizures and delayed hippocampal damage. The toxic effects of tacrine-loaded poly-L-lactid acid nanopar", "tokenized_content": [2, 7636, 4293, 3, 1964, 1981, 3615, 16, 6387, 13142, 5994, 4158, 10060, 1930, 7083, 7636, 4293, 18, 1920, 6161, 2564, 1927, 9214, 5773, 17, 7630, 4286, 17, 54, 17, 5641, 3]}, "items": [{"id": "p_2641", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_2642", "content": "tacrine [SEP] c seizures and delayed hippocampal damage. The toxic effects of tacrine-loaded poly-L-lactid acid nanoparticles (5mg/kg), a saline solu", "tokenized_content": [2, 9214, 5773, 3, 45, 10060, 1930, 7083, 7636, 4293, 18, 1920, 6161, 2564, 1927, 9214, 5773, 17, 7630, 4286, 17, 54, 17, 5641, 1960, 2687, 6897, 12, 25, 9759, 19, 3]}, "items": [{"id": "p_2642", "content": "Tacrine [SEP] A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxant", "score": 1, "type": null, "tokenized_content": [2, 9214, 5773, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 17553, 1920, 2877, 17, 3068, 7104, 18, 9214, 5773, 2258, 2252, 2251, 1942, 5836, 1920, 2564, 1927, 3760, 7327, 2031, 3]}]}
{"query": {"id": "q_2643", "content": "epileptic [SEP] rticles showed an earlier outcome of CNS adverse symptoms, i.e. epileptic onset, with respect to those animals treated with the free comp", "tokenized_content": [2, 16304, 3, 4341, 6193, 2594, 1925, 5556, 3924, 1927, 7520, 5246, 3601, 16, 51, 18, 47, 18, 16304, 4727, 16, 1956, 5633, 1942, 2690, 3555, 2868, 1956, 1920, 3294, 2059, 3]}, "items": [{"id": "p_2643", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2644", "content": "damage of neuronal cells [SEP] n addition, tacrine-loaded nanoparticles administration induced damage of neuronal cells in CA1 field of the hippocampus in all treated animals, while t", "tokenized_content": [2, 4293, 1927, 5121, 2094, 3, 56, 2459, 16, 9214, 5773, 17, 7630, 6897, 4183, 2719, 4293, 1927, 5121, 2094, 1922, 12961, 3559, 1927, 1920, 7661, 1922, 2136, 2868, 3555, 16, 3]}, "items": [{"id": "p_2644", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_2645", "content": "lithium [SEP]  severity of neurodegenerative processes induced by the tacrine-lithium model of epilepsy in the rat, could be used to evaluate prelimi", "tokenized_content": [2, 14330, 3, 5155, 1927, 11128, 4028, 2719, 2007, 1920, 9214, 5773, 17, 14330, 2322, 1927, 9741, 1922, 1920, 3067, 16, 2578, 1998, 2251, 1942, 4323, 8241, 1033, 3]}, "items": [{"id": "p_2645", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2646", "content": "epilepsy [SEP] odegenerative processes induced by the tacrine-lithium model of epilepsy in the rat, could be used to evaluate preliminarily the capabil", "tokenized_content": [2, 9741, 3, 4426, 6541, 25492, 2178, 4028, 2719, 2007, 1920, 9214, 5773, 17, 14330, 2322, 1927, 9741, 1922, 1920, 3067, 16, 2578, 1998, 2251, 1942, 4323, 8241, 29588, 1920, 2853, 3]}, "items": [{"id": "p_2646", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2647", "content": "pilocarpine [SEP] The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models.", "tokenized_content": [2, 7547, 7095, 12184, 3, 1920, 2246, 23246, 4913, 2495, 1930, 3216, 11478, 3531, 1927, 7547, 7095, 12184, 1990, 4027, 3130, 18, 3]}, "items": [{"id": "p_2647", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_2648", "content": "pilocarpine [SEP] This study was designed to evaluate the effects of pilocarpine and explore the underlying ionic mechanism, using both aconitin", "tokenized_content": [2, 7547, 7095, 12184, 3, 2052, 2161, 1982, 4609, 1942, 4323, 1920, 2564, 1927, 7547, 7095, 12184, 1930, 6414, 1920, 5030, 11478, 2856, 16, 2193, 2321, 2000, 27034, 1921, 3]}, "items": [{"id": "p_2648", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_2649", "content": "aconitine [SEP] ocarpine and explore the underlying ionic mechanism, using both aconitine-induced rat and ouabain-induced guinea pig arrhythmia models. C", "tokenized_content": [2, 2000, 27034, 2053, 3, 5084, 23457, 2053, 1930, 6414, 1920, 5030, 11478, 2856, 16, 2193, 2321, 2000, 27034, 2053, 17, 2719, 3067, 1930, 26274, 17, 2719, 12938, 5445, 18346, 3130, 3]}, "items": [{"id": "p_2649", "content": "Aconitine [SEP] A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has ", "score": 1, "type": null, "tokenized_content": [2, 2000, 27034, 2053, 3, 43, 8817, 1026, 20115, 23582, 20947, 29951, 12, 2137, 1967, 17125, 1918, 13, 2037, 1920, 5904, 1927, 2000, 27034, 1989, 4793, 18, 2176, 9094, 6889, 17, 12336, 5227, 5628, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_2650", "content": "ouabain [SEP] nderlying ionic mechanism, using both aconitine-induced rat and ouabain-induced guinea pig arrhythmia models. Confocal microscopy was u", "tokenized_content": [2, 26274, 3, 27594, 1005, 4142, 11478, 2856, 16, 2193, 2321, 2000, 27034, 2053, 17, 2719, 3067, 1930, 26274, 17, 2719, 12938, 5445, 18346, 3130, 18, 8085, 5441, 1982, 63, 3]}, "items": [{"id": "p_2650", "content": "Ouabain [SEP] A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants ", "score": 1, "type": null, "tokenized_content": [2, 26274, 3, 43, 21129, 3849, 7533, 2261, 7600, 1927, 23120, 2217, 1930, 26175, 4079, 1921, 16, 2926, 2037, 1920, 9869, 1927, 4943, 18547, 1963, 1957, 24689, 1031, 1957, 1930, 2303, 4793, 3]}]}
{"query": {"id": "q_2651", "content": "arrhythmia [SEP] using both aconitine-induced rat and ouabain-induced guinea pig arrhythmia models. Confocal microscopy was used to measure intracellular f", "tokenized_content": [2, 18346, 3, 2193, 2321, 2000, 27034, 2053, 17, 2719, 3067, 1930, 26274, 17, 2719, 12938, 5445, 18346, 3130, 18, 8085, 5441, 1982, 2251, 1942, 2931, 4776, 48, 3]}, "items": [{"id": "p_2651", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2652", "content": "calcium [SEP] els. Confocal microscopy was used to measure intracellular free-calcium concentrations ([Ca(2+)](i)) in isolated myocytes. The current ", "tokenized_content": [2, 5016, 3, 9614, 18, 8085, 5441, 1982, 2251, 1942, 2931, 4776, 3294, 17, 5016, 3295, 12, 37, 2332, 12, 22, 15, 13, 39, 12, 51, 13, 13, 1922, 3937, 14680, 3]}, "items": [{"id": "p_2652", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2653", "content": "Ca [SEP] was used to measure intracellular free-calcium concentrations ([Ca(2+)](i)) in isolated myocytes. The current data showed that pil", "tokenized_content": [2, 2332, 3, 1982, 2251, 1942, 2931, 4776, 3294, 17, 5016, 3295, 12, 37, 2332, 12, 22, 15, 13, 39, 12, 51, 13, 13, 1922, 3937, 14680, 18, 1920, 3214, 2230, 3]}, "items": [{"id": "p_2653", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2654", "content": "arrhythmias [SEP] ent data showed that pilocarpine significantly delayed onset of arrhythmias, decreased the time course of ventricular tachycardia and fibri", "tokenized_content": [2, 16934, 3, 8496, 2230, 2594, 1988, 7547, 7095, 12184, 2567, 7083, 4727, 1927, 16934, 16, 3261, 1920, 2367, 4914, 1927, 6493, 17397, 1930, 7953, 1033, 3]}, "items": [{"id": "p_2654", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2655", "content": "ventricular tachycardia [SEP] ntly delayed onset of arrhythmias, decreased the time course of ventricular tachycardia and fibrillation, reduced arrhythmia score, and increased the s", "tokenized_content": [2, 6493, 17397, 3, 5891, 1954, 7083, 4727, 1927, 16934, 16, 3261, 1920, 2367, 4914, 1927, 6493, 17397, 1930, 13671, 16, 3028, 18346, 3593, 16, 1930, 2502, 1920, 61, 3]}, "items": [{"id": "p_2655", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_2656", "content": "arrhythmic [SEP] n, reduced arrhythmia score, and increased the survival time of arrhythmic rats and guinea pigs. [Ca(2+)](i) overload induced by aconitine", "tokenized_content": [2, 11335, 4913, 3, 56, 16, 3028, 18346, 3593, 16, 1930, 2502, 1920, 3298, 2367, 1927, 11335, 4913, 3615, 1930, 12938, 9586, 18, 37, 2332, 12, 22, 15, 13, 39, 12, 3]}, "items": [{"id": "p_2656", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2657", "content": "acetylcholine [SEP] myocytes pretreated with pilocarpine. Moreover, M(3)-muscarinic acetylcholine receptor (mAChR) antagonist 4-DAMP (4-diphenylacetoxy-N-methylp", "tokenized_content": [2, 14561, 3, 14680, 12152, 1956, 7547, 7095, 12184, 18, 3950, 16, 55, 12, 23, 13, 17, 20318, 14561, 3148, 12, 6597, 1005, 13, 8151, 24, 17, 15515, 12, 24, 17, 3]}, "items": [{"id": "p_2657", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_2658", "content": "4-DAMP [SEP] over, M(3)-muscarinic acetylcholine receptor (mAChR) antagonist 4-DAMP (4-diphenylacetoxy-N-methylpiperidine-methiodide) partially abo", "tokenized_content": [2, 24, 17, 15515, 3, 2338, 16, 55, 12, 23, 13, 17, 20318, 14561, 3148, 12, 6597, 1005, 13, 8151, 24, 17, 15515, 12, 24, 17, 18190, 7681, 7221, 17, 56, 3]}, "items": [{"id": "p_2658", "content": "4-diphenylacetoxy-1,1-dimethylpiperidinium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 18190, 7681, 7221, 17, 21, 16, 21, 17, 9780, 10984, 2116, 24233, 3, 3]}]}
{"query": {"id": "q_2659", "content": "4-diphenylacetoxy-N-methylpiperidine-methiodide [SEP] 3)-muscarinic acetylcholine receptor (mAChR) antagonist 4-DAMP (4-diphenylacetoxy-N-methylpiperidine-methiodide) partially abolished the beneficial effects of pilocarpine. The", "tokenized_content": [2, 24, 17, 18190, 7681, 7221, 17, 56, 17, 4963, 10984, 2116, 5802, 17, 2295, 13025, 2261, 3, 23, 13, 17, 20318, 14561, 3148, 12, 6597, 1005, 13, 8151, 24, 17, 3]}, "items": [{"id": "p_2659", "content": "4-diphenylacetoxy-1,1-dimethylpiperidinium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 18190, 7681, 7221, 17, 21, 16, 21, 17, 9780, 10984, 2116, 24233, 3, 3]}]}
{"query": {"id": "q_2660", "content": "Disulfiram [SEP] Disulfiram-induced transient optic and peripheral neuropathy: a case repor", "tokenized_content": [2, 10993, 11979, 1035, 3, 10993, 11979, 1035, 17, 2719, 6809, 10109, 1930, 5009, 13177, 30, 43, 3087, 2424, 3]}, "items": [{"id": "p_2660", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_2661", "content": "peripheral neuropathy [SEP] Disulfiram-induced transient optic and peripheral neuropathy: a case report.", "tokenized_content": [2, 5009, 13177, 3, 10993, 11979, 1035, 17, 2719, 6809, 10109, 1930, 5009, 13177, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2661", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_2662", "content": "peripheral neuropathy [SEP] AIM: To report a case of optic and peripheral neuropathy after chronic use of disulfiram for alcohol dependence manageme", "tokenized_content": [2, 5009, 13177, 3, 3774, 30, 1942, 3809, 43, 3087, 1927, 10109, 1930, 5009, 13177, 2256, 3724, 2485, 1927, 10993, 11979, 1035, 1958, 4284, 6816, 12193, 3870, 3]}, "items": [{"id": "p_2662", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_2663", "content": "disulfiram [SEP]  a case of optic and peripheral neuropathy after chronic use of disulfiram for alcohol dependence management. MATERIALS AND METHODS: A cas", "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 3087, 1927, 10109, 1930, 5009, 13177, 2256, 3724, 2485, 1927, 10993, 11979, 1035, 1958, 4284, 6816, 4280, 18, 4751, 1930, 2860, 30, 43, 4373, 3]}, "items": [{"id": "p_2663", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_2664", "content": "alcohol dependence [SEP] c and peripheral neuropathy after chronic use of disulfiram for alcohol dependence management. MATERIALS AND METHODS: A case report. RESULTS: A 57", "tokenized_content": [2, 4284, 6816, 3, 45, 1930, 5009, 13177, 2256, 3724, 2485, 1927, 10993, 11979, 1035, 1958, 4284, 6816, 4280, 18, 4751, 1930, 2860, 30, 43, 3087, 3809, 18, 2274, 30, 43, 3]}, "items": [{"id": "p_2664", "content": "Alcoholism [SEP] A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations.", "score": 1, "type": null, "tokenized_content": [2, 19866, 3, 43, 3065, 16, 3724, 2573, 1956, 3299, 16, 10718, 16, 1930, 4813, 2790, 11623, 2496, 2740, 1930, 10952, 18, 3]}]}
{"query": {"id": "q_2665", "content": "loss of vision [SEP] case report. RESULTS: A 57-year-old male presented with gradual loss of vision in both eyes with intermittent headaches for 2 months. He also ", "tokenized_content": [2, 3257, 1927, 9266, 3, 3087, 3809, 18, 2274, 30, 43, 4786, 17, 2476, 17, 4156, 4005, 3549, 1956, 13802, 3257, 1927, 9266, 1922, 2321, 7127, 1956, 13252, 24339, 1958, 22, 3]}, "items": [{"id": "p_2665", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2666", "content": "headaches [SEP] nted with gradual loss of vision in both eyes with intermittent headaches for 2 months. He also complained of paraesthesia with numbness ", "tokenized_content": [2, 24339, 3, 5891, 1919, 1956, 13802, 3257, 1927, 9266, 1922, 2321, 7127, 1956, 13252, 24339, 1958, 22, 3221, 18, 2234, 2222, 26199, 1927, 8202, 29259, 1956, 25646, 2971, 3]}, "items": [{"id": "p_2666", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2667", "content": "paraesthesia [SEP] with intermittent headaches for 2 months. He also complained of paraesthesia with numbness in both feet. His vision was 6/15 and 2/60 in the", "tokenized_content": [2, 8202, 29259, 3, 1956, 13252, 24339, 1958, 22, 3221, 18, 2234, 2222, 26199, 1927, 8202, 29259, 1956, 25646, 2971, 1922, 2321, 18071, 18, 4167, 9266, 1982, 26, 19, 2461, 1930, 3]}, "items": [{"id": "p_2667", "content": "Paresthesia [SEP] Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence", "score": 1, "type": null, "tokenized_content": [2, 2096, 29259, 3, 9106, 11276, 26498, 12, 47, 18, 49, 18, 16, 6685, 16, 10142, 1963, 16, 12347, 4365, 1941, 16, 3772, 16, 8289, 18, 13, 1988, 2032, 6090, 12753, 1922, 1920, 3905, 3]}]}
{"query": {"id": "q_2668", "content": "numbness [SEP] headaches for 2 months. He also complained of paraesthesia with numbness in both feet. His vision was 6/15 and 2/60 in the right and lef", "tokenized_content": [2, 25646, 2971, 3, 24339, 1958, 22, 3221, 18, 2234, 2222, 26199, 1927, 8202, 29259, 1956, 25646, 2971, 1922, 2321, 18071, 18, 4167, 9266, 1982, 26, 19, 2461, 1930, 22, 19, 3]}, "items": [{"id": "p_2668", "content": "Hypesthesia [SEP] Absent or reduced sensitivity to cutaneous stimulation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2483, 29259, 3, 7685, 2014, 3028, 3802, 1942, 11276, 4177, 18, 3]}]}
{"query": {"id": "q_2669", "content": "scotomata [SEP]  heads. Visual field testing confirmed bilateral central-caecal scotomata. He had been taking disulfiram for alcohol dependence for the p", "tokenized_content": [2, 17162, 12700, 1019, 3, 16660, 18, 3737, 3559, 4213, 3982, 7787, 4101, 17, 2332, 8313, 17162, 12700, 1019, 18, 2234, 2430, 2252, 6303, 10993, 11979, 1035, 1958, 4284, 6816, 1958, 3]}, "items": [{"id": "p_2669", "content": "Scotoma [SEP] A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of EYE DISEASES (e.g., R", "score": 1, "type": null, "tokenized_content": [2, 17162, 2954, 3, 43, 6579, 7374, 1922, 1920, 3737, 3559, 9380, 1919, 2007, 1925, 3403, 1927, 2791, 9266, 18, 2052, 5110, 1956, 43, 5386, 1927, 5723, 3902, 12, 47, 18, 49, 18, 16, 60, 3]}]}
{"query": {"id": "q_2670", "content": "Disulfiram [SEP] ng disulfiram for alcohol dependence for the preceding 3 years. Disulfiram discontinuation lead to an immediate symptomatic improvement. C", "tokenized_content": [2, 10993, 11979, 1035, 3, 4375, 10993, 11979, 1035, 1958, 4284, 6816, 1958, 1920, 12141, 23, 2739, 18, 10993, 11979, 1035, 14775, 2949, 1942, 1925, 8426, 9371, 4990, 18, 45, 3]}, "items": [{"id": "p_2670", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_2671", "content": "hepatitis B [SEP] Sustained clinical improvement of a patient with decompensated hepatitis B virus-related cirrhosis after treatment with lamivudine monothe", "tokenized_content": [2, 7977, 44, 3, 7637, 2535, 4990, 1927, 43, 2774, 1956, 24691, 1981, 7977, 44, 3413, 17, 2712, 11260, 2256, 2311, 1956, 30208, 19399, 4116, 3]}, "items": [{"id": "p_2671", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2672", "content": "cirrhosis [SEP] ement of a patient with decompensated hepatitis B virus-related cirrhosis after treatment with lamivudine monotherapy.", "tokenized_content": [2, 11260, 3, 2391, 1939, 1927, 43, 2774, 1956, 24691, 1981, 7977, 44, 3413, 17, 2712, 11260, 2256, 2311, 1956, 30208, 13767, 18, 3]}, "items": [{"id": "p_2672", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2673", "content": "lamivudine [SEP] nsated hepatitis B virus-related cirrhosis after treatment with lamivudine monotherapy.", "tokenized_content": [2, 30208, 3, 4246, 1981, 7977, 44, 3413, 17, 2712, 11260, 2256, 2311, 1956, 30208, 13767, 18, 3]}, "items": [{"id": "p_2673", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2674", "content": "Hepatitis B virus (HBV) infection [SEP] Hepatitis B virus (HBV) infection, which causes liver cirrhosis and hepatocellular carcinoma, rem", "tokenized_content": [2, 7977, 44, 3413, 12, 8738, 13, 2909, 3, 7977, 44, 3413, 12, 8738, 13, 2909, 16, 2154, 5092, 3568, 11260, 1930, 12457, 5373, 16, 2500, 3]}, "items": [{"id": "p_2674", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2675", "content": "liver cirrhosis [SEP] Hepatitis B virus (HBV) infection, which causes liver cirrhosis and hepatocellular carcinoma, remains a major health problem in", "tokenized_content": [2, 3568, 11260, 3, 7977, 44, 3413, 12, 8738, 13, 2909, 16, 2154, 5092, 3568, 11260, 1930, 12457, 5373, 16, 4497, 43, 3044, 2436, 4915, 1922, 3]}, "items": [{"id": "p_2675", "content": "Liver Cirrhosis [SEP] Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably ", "score": 1, "type": null, "tokenized_content": [2, 3568, 11260, 3, 3568, 2573, 1922, 2154, 1920, 2791, 27469, 16, 1920, 10461, 4541, 12843, 16, 1930, 1920, 6095, 9335, 2162, 2252, 2309, 3458, 3]}]}
{"query": {"id": "q_2676", "content": "hepatocellular carcinoma [SEP] titis B virus (HBV) infection, which causes liver cirrhosis and hepatocellular carcinoma, remains a major health problem in Asian countries. Recent deve", "tokenized_content": [2, 12457, 5373, 3, 7090, 1937, 44, 3413, 12, 8738, 13, 2909, 16, 2154, 5092, 3568, 11260, 1930, 12457, 5373, 16, 4497, 43, 3044, 2436, 4915, 1922, 9686, 5085, 18, 3505, 3]}, "items": [{"id": "p_2676", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_2677", "content": "cirrhosis [SEP] Hepatitis B virus (HBV) infection, which causes liver cirrhosis and hepatocellular carcinoma, remains a major health problem in", "tokenized_content": [2, 11260, 3, 7977, 44, 3413, 12, 8738, 13, 2909, 16, 2154, 5092, 3568, 11260, 1930, 12457, 5373, 16, 4497, 43, 3044, 2436, 4915, 1922, 3]}, "items": [{"id": "p_2677", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2678", "content": "lamivudine [SEP] d been referred to our hospital. However, the administration of lamivudine, a reverse transcriptase inhibitor, for 23 months dramatically ", "tokenized_content": [2, 30208, 3, 46, 2252, 6656, 1942, 2342, 3461, 18, 2406, 16, 1920, 4183, 1927, 30208, 16, 43, 5267, 13335, 4106, 16, 1958, 3020, 3221, 9602, 3]}, "items": [{"id": "p_2678", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2679", "content": "hepatitis B surface antigen [SEP] en after the antiviral therapy was discontinued. Moreover, both hepatitis B surface antigen and e antigen were observed to have disappeared in this patient", "tokenized_content": [2, 7977, 44, 3154, 4730, 3, 2066, 2256, 1920, 10129, 3181, 1982, 16087, 18, 3950, 16, 2321, 7977, 44, 3154, 4730, 1930, 47, 4730, 1985, 2528, 1942, 2162, 15588, 1922, 2052, 3]}, "items": [{"id": "p_2679", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_2680", "content": "melatonin [SEP] Dual effects of melatonin on barbiturate-induced narcosis in rats.", "tokenized_content": [2, 13366, 3, 7064, 2564, 1927, 13366, 1990, 30434, 4219, 5524, 2057, 17, 2719, 22872, 2475, 1922, 3615, 18, 3]}, "items": [{"id": "p_2680", "content": "Melatonin [SEP] A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion incre", "score": 1, "type": null, "tokenized_content": [2, 13366, 3, 43, 24241, 19730, 13610, 1988, 1977, 2435, 1922, 3555, 1930, 4793, 18, 1922, 9902, 16, 13366, 1977, 4152, 2007, 1920, 27719, 8359, 18, 2496, 5512, 2203, 3]}]}
{"query": {"id": "q_2681", "content": "barbiturate [SEP] Dual effects of melatonin on barbiturate-induced narcosis in rats.", "tokenized_content": [2, 30434, 4219, 5524, 2057, 3, 7064, 2564, 1927, 13366, 1990, 30434, 4219, 5524, 2057, 17, 2719, 22872, 2475, 1922, 3615, 18, 3]}, "items": [{"id": "p_2681", "content": "barbituric acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 30434, 4219, 3133, 2687, 3, 3]}]}
{"query": {"id": "q_2682", "content": "narcosis [SEP] Dual effects of melatonin on barbiturate-induced narcosis in rats.", "tokenized_content": [2, 22872, 2475, 3, 7064, 2564, 1927, 13366, 1990, 30434, 4219, 5524, 2057, 17, 2719, 22872, 2475, 1922, 3615, 18, 3]}, "items": [{"id": "p_2682", "content": "Stupor [SEP] A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vig", "score": 1, "type": null, "tokenized_content": [2, 1955, 3481, 1924, 3, 43, 3360, 1927, 3028, 2658, 3687, 1930, 2644, 1942, 5458, 2154, 1977, 12080, 2037, 22337, 1922, 1988, 1920, 5952, 2112, 1998, 12529, 6107, 2007, 11505, 3]}]}
{"query": {"id": "q_2683", "content": "Melatonin [SEP] Melatonin affects the circadian sleep/wake cycle, but it is not clear whe", "tokenized_content": [2, 13366, 3, 13366, 6886, 1920, 10507, 5006, 19, 14763, 4048, 16, 2308, 2176, 1977, 2084, 4021, 8372, 3]}, "items": [{"id": "p_2683", "content": "Melatonin [SEP] A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion incre", "score": 1, "type": null, "tokenized_content": [2, 13366, 3, 43, 24241, 19730, 13610, 1988, 1977, 2435, 1922, 3555, 1930, 4793, 18, 1922, 9902, 16, 13366, 1977, 4152, 2007, 1920, 27719, 8359, 18, 2496, 5512, 2203, 3]}]}
{"query": {"id": "q_2684", "content": "narcosis [SEP] ycle, but it is not clear whether it may influence drug-induced narcosis. Sodium thiopenthal was administered intraperitoneally into mal", "tokenized_content": [2, 22872, 2475, 3, 22386, 1952, 16, 2308, 2176, 1977, 2084, 4021, 3053, 2176, 2278, 4039, 2838, 17, 2719, 22872, 2475, 18, 5227, 15331, 17125, 8025, 1982, 5254, 17245, 2460, 3054, 3]}, "items": [{"id": "p_2684", "content": "Stupor [SEP] A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vig", "score": 1, "type": null, "tokenized_content": [2, 1955, 3481, 1924, 3, 43, 3360, 1927, 3028, 2658, 3687, 1930, 2644, 1942, 5458, 2154, 1977, 12080, 2037, 22337, 1922, 1988, 1920, 5952, 2112, 1998, 12529, 6107, 2007, 11505, 3]}]}
{"query": {"id": "q_2685", "content": "Sodium thiopenthal [SEP] it is not clear whether it may influence drug-induced narcosis. Sodium thiopenthal was administered intraperitoneally into male rats pre-treated w", "tokenized_content": [2, 5227, 15331, 17125, 8025, 3, 2176, 1977, 2084, 4021, 3053, 2176, 2278, 4039, 2838, 17, 2719, 22872, 2475, 18, 5227, 15331, 17125, 8025, 1982, 5254, 17245, 2460, 4005, 3615, 2097, 3]}, "items": [{"id": "p_2685", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_2686", "content": "melatonin [SEP]  administered intraperitoneally into male rats pre-treated with melatonin (0.05, 0.5, 5 and 50 mg/kg). Melatonin pre-treatment affected i", "tokenized_content": [2, 13366, 3, 5254, 17245, 2460, 4005, 3615, 2097, 17, 2868, 1956, 13366, 12, 20, 18, 2914, 16, 20, 18, 25, 16, 25, 1930, 2761, 2786, 19, 3621, 13, 18, 13366, 3]}, "items": [{"id": "p_2686", "content": "Melatonin [SEP] A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion incre", "score": 1, "type": null, "tokenized_content": [2, 13366, 3, 43, 24241, 19730, 13610, 1988, 1977, 2435, 1922, 3555, 1930, 4793, 18, 1922, 9902, 16, 13366, 1977, 4152, 2007, 1920, 27719, 8359, 18, 2496, 5512, 2203, 3]}]}
{"query": {"id": "q_2687", "content": "barbiturate [SEP] nd 50 mg/kg). Melatonin pre-treatment affected in a dual manner barbiturate narcosis, however, no dose-effect correlation was found. In par", "tokenized_content": [2, 30434, 4219, 5524, 2057, 3, 8026, 2761, 2786, 19, 3621, 13, 18, 13366, 2097, 17, 2311, 4218, 1922, 43, 7064, 5222, 30434, 4219, 5524, 2057, 22872, 2475, 16, 2406, 16, 3]}, "items": [{"id": "p_2687", "content": "barbituric acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 30434, 4219, 3133, 2687, 3, 3]}]}
{"query": {"id": "q_2688", "content": "ketamine [SEP]  0.5 and 5 mg/kg influenced the duration but not the latency of ketamine- or diazepam-induced narcosis. Thus, the dual action of melaton", "tokenized_content": [2, 14049, 3, 20, 18, 25, 1930, 25, 2786, 19, 3621, 6950, 1920, 4392, 2308, 2084, 1920, 9393, 1927, 14049, 17, 2014, 26079, 17, 2719, 22872, 2475, 18, 2842, 16, 1920, 3]}, "items": [{"id": "p_2688", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2689", "content": "diazepam [SEP] /kg influenced the duration but not the latency of ketamine- or diazepam-induced narcosis. Thus, the dual action of melatonin on pharmac", "tokenized_content": [2, 26079, 3, 19, 3621, 6950, 1920, 4392, 2308, 2084, 1920, 9393, 1927, 14049, 17, 2014, 26079, 17, 2719, 22872, 2475, 18, 2842, 16, 1920, 7064, 4615, 1927, 13366, 1990, 4602, 3]}, "items": [{"id": "p_2689", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_2690", "content": "NIK-247 [SEP] Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.", "tokenized_content": [2, 12833, 17, 20892, 3, 2564, 1927, 12833, 17, 20892, 1990, 15440, 2156, 7124, 4127, 1930, 25392, 10173, 25157, 17, 2719, 14701, 7156, 18, 3]}, "items": [{"id": "p_2690", "content": "amiridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15665, 20332, 2053, 3, 3]}]}
{"query": {"id": "q_2691", "content": "scopolamine [SEP] Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.", "tokenized_content": [2, 25392, 10173, 25157, 3, 2564, 1927, 12833, 17, 20892, 1990, 15440, 2156, 7124, 4127, 1930, 25392, 10173, 25157, 17, 2719, 14701, 7156, 18, 3]}, "items": [{"id": "p_2691", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_2692", "content": "amnesia [SEP] Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.", "tokenized_content": [2, 14701, 7156, 3, 2564, 1927, 12833, 17, 20892, 1990, 15440, 2156, 7124, 4127, 1930, 25392, 10173, 25157, 17, 2719, 14701, 7156, 18, 3]}, "items": [{"id": "p_2692", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_2693", "content": "NIK-247 [SEP] The effects of NIK-247 on cholinesterase, scopolamine-induced amnesia and spontaneous ", "tokenized_content": [2, 12833, 17, 20892, 3, 1920, 2564, 1927, 12833, 17, 20892, 1990, 15440, 2156, 7124, 4127, 16, 25392, 10173, 25157, 17, 2719, 14701, 7156, 1930, 6242, 3]}, "items": [{"id": "p_2693", "content": "amiridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15665, 20332, 2053, 3, 3]}]}
{"query": {"id": "q_2694", "content": "scopolamine [SEP] The effects of NIK-247 on cholinesterase, scopolamine-induced amnesia and spontaneous movement were examined and comp", "tokenized_content": [2, 25392, 10173, 25157, 3, 1920, 2564, 1927, 12833, 17, 20892, 1990, 15440, 2156, 7124, 4127, 16, 25392, 10173, 25157, 17, 2719, 14701, 7156, 1930, 6242, 5829, 1985, 3572, 1930, 2059, 3]}, "items": [{"id": "p_2694", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_2695", "content": "amnesia [SEP] The effects of NIK-247 on cholinesterase, scopolamine-induced amnesia and spontaneous movement were examined and compared with those ", "tokenized_content": [2, 14701, 7156, 3, 1920, 2564, 1927, 12833, 17, 20892, 1990, 15440, 2156, 7124, 4127, 16, 25392, 10173, 25157, 17, 2719, 14701, 7156, 1930, 6242, 5829, 1985, 3572, 1930, 2452, 1956, 3]}, "items": [{"id": "p_2695", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_2696", "content": "tacrine [SEP] compared with those of the well-known cholinesterase inhibitors tacrine and E-2020. NIK-247, tacrine and E-2020 all strongly inhibited ", "tokenized_content": [2, 9214, 5773, 3, 2452, 1956, 2690, 1927, 1920, 2486, 17, 3171, 15440, 2156, 7124, 4127, 4472, 9214, 5773, 1930, 47, 17, 22656, 18, 12833, 17, 20892, 16, 9214, 5773, 1930, 3]}, "items": [{"id": "p_2696", "content": "Tacrine [SEP] A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxant", "score": 1, "type": null, "tokenized_content": [2, 9214, 5773, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 17553, 1920, 2877, 17, 3068, 7104, 18, 9214, 5773, 2258, 2252, 2251, 1942, 5836, 1920, 2564, 1927, 3760, 7327, 2031, 3]}]}
{"query": {"id": "q_2697", "content": "E-2020 [SEP] h those of the well-known cholinesterase inhibitors tacrine and E-2020. NIK-247, tacrine and E-2020 all strongly inhibited acetylcholi", "tokenized_content": [2, 47, 17, 22656, 3, 50, 2690, 1927, 1920, 2486, 17, 3171, 15440, 2156, 7124, 4127, 4472, 9214, 5773, 1930, 47, 17, 22656, 18, 12833, 17, 20892, 16, 9214, 5773, 1930, 3]}, "items": [{"id": "p_2697", "content": "donepezil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5404, 9626, 22030, 1024, 3, 3]}]}
{"query": {"id": "q_2698", "content": "Alzheimer's disease [SEP]  suggest that NIK-247 may be a useful drug for the treatment of Alzheimer's disease.", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 3220, 1988, 12833, 17, 20892, 2278, 1998, 43, 4707, 2838, 1958, 1920, 2311, 1927, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2698", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_2699", "content": "hallucinations [SEP] Nightmares and hallucinations after long-term intake of tramadol combined with antidepressant", "tokenized_content": [2, 27013, 3, 9609, 19252, 1918, 1930, 27013, 2256, 2815, 17, 2576, 5240, 1927, 23179, 28280, 4252, 1956, 14183, 3]}, "items": [{"id": "p_2699", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2700", "content": "tramadol [SEP] Nightmares and hallucinations after long-term intake of tramadol combined with antidepressants.", "tokenized_content": [2, 23179, 28280, 3, 9609, 19252, 1918, 1930, 27013, 2256, 2815, 17, 2576, 5240, 1927, 23179, 28280, 4252, 1956, 17722, 18, 3]}, "items": [{"id": "p_2700", "content": "Tramadol [SEP] A narcotic analgesic proposed for severe pain. It may be habituating.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23179, 28280, 3, 43, 22872, 3153, 14501, 4211, 1958, 4010, 3594, 18, 2176, 2278, 1998, 18814, 2287, 18, 3]}]}
{"query": {"id": "q_2701", "content": "Tramadol [SEP] Tramadol is a weak opioid with effects on adrenergic and serotonergic ne", "tokenized_content": [2, 23179, 28280, 3, 23179, 28280, 1977, 43, 5015, 9384, 1956, 2564, 1990, 13672, 1930, 21292, 2069, 3]}, "items": [{"id": "p_2701", "content": "Tramadol [SEP] A narcotic analgesic proposed for severe pain. It may be habituating.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23179, 28280, 3, 43, 22872, 3153, 14501, 4211, 1958, 4010, 3594, 18, 2176, 2278, 1998, 18814, 2287, 18, 3]}]}
{"query": {"id": "q_2702", "content": "cancer [SEP] nergic and serotonergic neurotransmission that is used to treat cancer pain and chronic non malignant pain. This drug was initiated in", "tokenized_content": [2, 2539, 3, 4919, 11545, 1930, 21292, 20221, 1988, 1977, 2251, 1942, 2297, 2539, 3594, 1930, 3724, 2447, 6558, 3594, 18, 2052, 2838, 1982, 7796, 1922, 3]}, "items": [{"id": "p_2702", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_2703", "content": "pain [SEP] and serotonergic neurotransmission that is used to treat cancer pain and chronic non malignant pain. This drug was initiated in asso", "tokenized_content": [2, 3594, 3, 1930, 21292, 20221, 1988, 1977, 2251, 1942, 2297, 2539, 3594, 1930, 3724, 2447, 6558, 3594, 18, 2052, 2838, 1982, 7796, 1922, 2088, 1037, 3]}, "items": [{"id": "p_2703", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2704", "content": "paroxetine [SEP] non malignant pain. This drug was initiated in association with paroxetine and dosulepine hydrochloride in a tetraparetic patient with chr", "tokenized_content": [2, 21412, 15387, 3, 2447, 6558, 3594, 18, 2052, 2838, 1982, 7796, 1922, 3279, 1956, 21412, 15387, 1930, 4220, 3466, 12184, 16675, 1922, 43, 28000, 2768, 2002, 2774, 1956, 8777, 3]}, "items": [{"id": "p_2704", "content": "Paroxetine [SEP] A serotonin uptake inhibitor that is effective in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21412, 15387, 3, 43, 11153, 5047, 4106, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_2705", "content": "dosulepine hydrochloride [SEP] ain. This drug was initiated in association with paroxetine and dosulepine hydrochloride in a tetraparetic patient with chronic pain. Fifty-six days aft", "tokenized_content": [2, 4220, 3466, 12184, 16675, 3, 9798, 1022, 18, 2052, 2838, 1982, 7796, 1922, 3279, 1956, 21412, 15387, 1930, 4220, 3466, 12184, 16675, 1922, 43, 28000, 2768, 2002, 2774, 1956, 3724, 3]}, "items": [{"id": "p_2705", "content": "Dothiepin [SEP] A tricyclic antidepressant with some tranquilizing action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8522, 7969, 2128, 1921, 3, 43, 12258, 13153, 14183, 1956, 2673, 29808, 2048, 5912, 9046, 4615, 18, 3]}]}
{"query": {"id": "q_2706", "content": "chronic pain [SEP] ine and dosulepine hydrochloride in a tetraparetic patient with chronic pain. Fifty-six days after initiation of the treatment the patient p", "tokenized_content": [2, 3724, 3594, 3, 11116, 1930, 4220, 3466, 12184, 16675, 1922, 43, 28000, 2768, 2002, 2774, 1956, 3724, 3594, 18, 12357, 17, 3798, 3000, 2256, 6035, 1927, 1920, 2311, 1920, 2774, 3]}, "items": [{"id": "p_2706", "content": "Chronic Pain [SEP] Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persi", "score": 1, "type": null, "tokenized_content": [2, 3724, 3594, 3, 3546, 1941, 15826, 1988, 20350, 1958, 2253, 2254, 43, 3855, 3221, 18, 2176, 2278, 2014, 2278, 2084, 1998, 2458, 1956, 7176, 2014, 2573, 16, 1930, 2278, 3096, 1033, 3]}]}
{"query": {"id": "q_2707", "content": "hallucinations [SEP] ix days after initiation of the treatment the patient presented hallucinations that only stopped after the withdrawal of psycho-active drugs a", "tokenized_content": [2, 27013, 3, 13848, 3000, 2256, 6035, 1927, 1920, 2311, 1920, 2774, 3549, 27013, 1988, 2444, 12032, 2256, 1920, 9594, 1927, 18740, 17, 3500, 4195, 43, 3]}, "items": [{"id": "p_2707", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2708", "content": "tramadol [SEP] at only stopped after the withdrawal of psycho-active drugs and tramadol. The case report questions the long term use of pain killers co", "tokenized_content": [2, 23179, 28280, 3, 2019, 2444, 12032, 2256, 1920, 9594, 1927, 18740, 17, 3500, 4195, 1930, 23179, 28280, 18, 1920, 3087, 3809, 5610, 1920, 2815, 2576, 2485, 1927, 3594, 16644, 1036, 3]}, "items": [{"id": "p_2708", "content": "Tramadol [SEP] A narcotic analgesic proposed for severe pain. It may be habituating.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23179, 28280, 3, 43, 22872, 3153, 14501, 4211, 1958, 4010, 3594, 18, 2176, 2278, 1998, 18814, 2287, 18, 3]}]}
{"query": {"id": "q_2709", "content": "rheumatoid arthritis [SEP] Apparent cure of rheumatoid arthritis by bone marrow transplantation.", "tokenized_content": [2, 13053, 8884, 3, 6273, 12338, 1927, 13053, 8884, 2007, 3622, 6599, 6530, 18, 3]}, "items": [{"id": "p_2709", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_2710", "content": "rheumatoid arthritis [SEP] ion of sustained remissions and possible cure of severe erosive rheumatoid arthritis (RA) by bone marrow transplantation (BMT) in 2 patients. BMT wa", "tokenized_content": [2, 13053, 8884, 3, 4755, 1927, 7637, 10221, 1036, 1930, 3216, 12338, 1927, 4010, 23898, 2320, 13053, 8884, 12, 4313, 13, 2007, 3622, 6599, 6530, 12, 24037, 13, 1922, 22, 2132, 3]}, "items": [{"id": "p_2710", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_2711", "content": "RA [SEP] sions and possible cure of severe erosive rheumatoid arthritis (RA) by bone marrow transplantation (BMT) in 2 patients. BMT was us", "tokenized_content": [2, 4313, 3, 5998, 2101, 1930, 3216, 12338, 1927, 4010, 23898, 2320, 13053, 8884, 12, 4313, 13, 2007, 3622, 6599, 6530, 12, 24037, 13, 1922, 22, 2132, 18, 24037, 1982, 2022, 3]}, "items": [{"id": "p_2711", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_2712", "content": "aplastic anemia [SEP] ansplantation (BMT) in 2 patients. BMT was used to treat severe aplastic anemia which was caused by gold in one case and D-penicillamine in the", "tokenized_content": [2, 18373, 4054, 10679, 3, 18229, 18751, 12, 24037, 13, 1922, 22, 2132, 18, 24037, 1982, 2251, 1942, 2297, 4010, 18373, 4054, 10679, 2154, 1982, 4189, 2007, 6557, 1922, 2340, 3087, 3]}, "items": [{"id": "p_2712", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_2713", "content": "gold [SEP] MT was used to treat severe aplastic anemia which was caused by gold in one case and D-penicillamine in the other. In the 8 and 6 ye", "tokenized_content": [2, 6557, 3, 4638, 1982, 2251, 1942, 2297, 4010, 18373, 4054, 10679, 2154, 1982, 4189, 2007, 6557, 1922, 2340, 3087, 1930, 46, 17, 25142, 3812, 1922, 1920, 2303, 18, 1922, 1920, 3]}, "items": [{"id": "p_2713", "content": "Gold [SEP] A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating", "score": 1, "type": null, "tokenized_content": [2, 6557, 3, 43, 7463, 16790, 6149, 1956, 1920, 11241, 17530, 5759, 16, 11241, 2529, 5637, 16, 1930, 11241, 3388, 5876, 18, 2176, 1977, 2251, 1922, 28296, 1938, 6907, 16, 6557, 8516, 1029, 3]}]}
{"query": {"id": "q_2714", "content": "D-penicillamine [SEP] severe aplastic anemia which was caused by gold in one case and D-penicillamine in the other. In the 8 and 6 years since the transplants (repre", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 4010, 18373, 4054, 10679, 2154, 1982, 4189, 2007, 6557, 1922, 2340, 3087, 1930, 46, 17, 25142, 3812, 1922, 1920, 2303, 18, 1922, 1920, 28, 1930, 3]}, "items": [{"id": "p_2714", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_2715", "content": "synovitis [SEP] a therapeutic option for patients with uncontrolled destructive synovitis.", "tokenized_content": [2, 27481, 3600, 3, 43, 4272, 8297, 1958, 2132, 1956, 15734, 21243, 27481, 3600, 18, 3]}, "items": [{"id": "p_2715", "content": "Synovitis [SEP] Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelli", "score": 1, "type": null, "tokenized_content": [2, 27481, 3600, 3, 4531, 1927, 43, 14828, 3260, 18, 2176, 1977, 5394, 15806, 16, 4443, 1990, 6269, 16, 1930, 1977, 4378, 2007, 43, 26138, 9736, 11560, 1033, 3]}]}
{"query": {"id": "q_2716", "content": "injury to different regions of the kidney [SEP] Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney.", "tokenized_content": [2, 4047, 1942, 2413, 3451, 1927, 1920, 5245, 3, 7075, 5038, 1930, 2213, 4147, 1966, 8373, 1927, 4047, 1942, 2413, 3451, 1927, 1920, 5245, 18, 3]}, "items": [{"id": "p_2716", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2717", "content": "Acute experimental models of renal damage [SEP] Acute experimental models of renal damage to the proximal tubular, glomerular, and papillary regions of t", "tokenized_content": [2, 3939, 3599, 3130, 1927, 4604, 4293, 3, 3939, 3599, 3130, 1927, 4604, 4293, 1942, 1920, 6863, 11755, 16, 11655, 16, 1930, 15787, 3451, 1927, 62, 3]}, "items": [{"id": "p_2717", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_2718", "content": "hexachloro-1:3-butadiene [SEP] papillary regions of the rat were produced by administration of hexachloro-1:3-butadiene (HCBD), puromycin aminonucleoside (PAN), and 2-bromoethylamine ", "tokenized_content": [2, 7142, 22918, 1037, 17, 21, 30, 23, 17, 2308, 2713, 2880, 3, 15787, 3451, 1927, 1920, 3067, 1985, 4152, 2007, 4183, 1927, 7142, 22918, 1037, 17, 21, 30, 23, 17, 3]}, "items": [{"id": "p_2718", "content": "hexachlorobutadiene [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7142, 22918, 14253, 2713, 2880, 3, 3]}]}
{"query": {"id": "q_2719", "content": "HCBD [SEP] at were produced by administration of hexachloro-1:3-butadiene (HCBD), puromycin aminonucleoside (PAN), and 2-bromoethylamine (BEA),", "tokenized_content": [2, 4387, 13602, 3, 2019, 1985, 4152, 2007, 4183, 1927, 7142, 22918, 1037, 17, 21, 30, 23, 17, 2308, 2713, 2880, 12, 4387, 13602, 13, 16, 19750, 3835, 1022, 2626, 8028, 3]}, "items": [{"id": "p_2719", "content": "hexachlorobutadiene [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7142, 22918, 14253, 2713, 2880, 3, 3]}]}
{"query": {"id": "q_2720", "content": "puromycin aminonucleoside [SEP]  produced by administration of hexachloro-1:3-butadiene (HCBD), puromycin aminonucleoside (PAN), and 2-bromoethylamine (BEA), respectively. Several routi", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 4152, 2007, 4183, 1927, 7142, 22918, 1037, 17, 21, 30, 23, 17, 2308, 2713, 2880, 12, 4387, 13602, 13, 16, 19750, 3835, 1022, 2626, 3]}, "items": [{"id": "p_2720", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2721", "content": "PAN [SEP]  of hexachloro-1:3-butadiene (HCBD), puromycin aminonucleoside (PAN), and 2-bromoethylamine (BEA), respectively. Several routine in", "tokenized_content": [2, 3797, 3, 1927, 7142, 22918, 1037, 17, 21, 30, 23, 17, 2308, 2713, 2880, 12, 4387, 13602, 13, 16, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 16, 1930, 22, 3]}, "items": [{"id": "p_2721", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2722", "content": "2-bromoethylamine [SEP] loro-1:3-butadiene (HCBD), puromycin aminonucleoside (PAN), and 2-bromoethylamine (BEA), respectively. Several routine indicators of nephrotoxici", "tokenized_content": [2, 22, 17, 21392, 5188, 3812, 3, 16394, 1037, 17, 21, 30, 23, 17, 2308, 2713, 2880, 12, 4387, 13602, 13, 16, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 16, 3]}, "items": [{"id": "p_2722", "content": "2-bromoethylamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 21392, 5188, 3812, 3, 3]}]}
{"query": {"id": "q_2723", "content": "BEA [SEP] (HCBD), puromycin aminonucleoside (PAN), and 2-bromoethylamine (BEA), respectively. Several routine indicators of nephrotoxicity, t", "tokenized_content": [2, 1998, 1019, 3, 12, 4387, 13602, 13, 16, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 16, 1930, 22, 17, 21392, 5188, 3812, 12, 1998, 1019, 13, 16, 2763, 18, 3]}, "items": [{"id": "p_2723", "content": "2-bromoethylamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 21392, 5188, 3812, 3, 3]}]}
{"query": {"id": "q_2724", "content": "nephrotoxicity [SEP] moethylamine (BEA), respectively. Several routine indicators of nephrotoxicity, the enzymes alkaline phosphatase and N-acetyl-beta-glucosamini", "tokenized_content": [2, 27880, 3, 2661, 5188, 3812, 12, 1998, 1019, 13, 16, 2763, 18, 2980, 7341, 8373, 1927, 27880, 16, 1920, 5038, 10746, 8167, 1930, 56, 17, 6894, 17, 4666, 17, 3351, 3]}, "items": [{"id": "p_2724", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2725", "content": "protein excretion [SEP]  and N-acetyl-beta-glucosaminidase, and the molecular weight of protein excretion were determined on urine samples. Tubular damage produced by HC", "tokenized_content": [2, 2213, 11093, 3, 1930, 56, 17, 6894, 17, 4666, 17, 3351, 5360, 8547, 9200, 16, 1930, 1920, 3272, 3388, 1927, 2213, 11093, 1985, 3180, 1990, 6960, 2785, 18, 11755, 4293, 3]}, "items": [{"id": "p_2725", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2726", "content": "glomerular damage [SEP] EA was discriminated both quantitatively and qualitatively from glomerular damage produced by PAN. The latter was characterized by a pronounced i", "tokenized_content": [2, 11655, 4293, 3, 11377, 1982, 25867, 2321, 12469, 1930, 15480, 2037, 11655, 4293, 4152, 2007, 3797, 18, 1920, 6296, 1982, 4378, 2007, 43, 9079, 51, 3]}, "items": [{"id": "p_2726", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2727", "content": "excretion of proteins [SEP] in tubular damage was raised only slightly and characterized by excretion of proteins of a wide range of molecular weights. Proximal tubular damage c", "tokenized_content": [2, 11093, 1927, 2697, 3, 1922, 11755, 4293, 1982, 8930, 2444, 5733, 1930, 4378, 2007, 11093, 1927, 2697, 1927, 43, 4743, 3109, 1927, 3272, 8845, 18, 6863, 11755, 4293, 45, 3]}, "items": [{"id": "p_2727", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2728", "content": "glucose [SEP] easurement of the two urinary enzymes. Alkaline phosphatase and glucose were markedly and transiently elevated in proximal tubular dama", "tokenized_content": [2, 3817, 3, 4843, 29228, 1927, 1920, 2288, 7075, 5038, 18, 10746, 8167, 1930, 3817, 1985, 7686, 1930, 12145, 4664, 1922, 6863, 11755, 3787, 1019, 3]}, "items": [{"id": "p_2728", "content": "Glucose [SEP] A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in i", "score": 1, "type": null, "tokenized_content": [2, 3817, 3, 43, 3065, 4585, 1927, 3844, 1958, 5818, 7373, 18, 2176, 1977, 10414, 6966, 1930, 1977, 2435, 1922, 12953, 1930, 2303, 7516, 1927, 4793, 1922, 51, 3]}]}
{"query": {"id": "q_2729", "content": "renal damage [SEP] Acute experimental models of renal damage to the proximal tubular, glomerular, and papillary regions of t", "tokenized_content": [2, 4604, 4293, 3, 3939, 3599, 3130, 1927, 4604, 4293, 1942, 1920, 6863, 11755, 16, 11655, 16, 1930, 15787, 3451, 1927, 62, 3]}, "items": [{"id": "p_2729", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2730", "content": "Neuromuscular blockade [SEP] Neuromuscular blockade with magnesium sulfate and nifedipine.", "tokenized_content": [2, 15829, 9847, 3, 15829, 9847, 1956, 13148, 8767, 1930, 25968, 18, 3]}, "items": [{"id": "p_2730", "content": "Neuromuscular Manifestations [SEP] Signs and symptoms associated with diseases of the muscle, neuromuscular junction, or peripheral nerves.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15829, 10952, 3, 6879, 1930, 3601, 2458, 1956, 3902, 1927, 1920, 3760, 16, 15829, 6910, 16, 2014, 5009, 12014, 18, 3]}]}
{"query": {"id": "q_2731", "content": "magnesium sulfate [SEP] Neuromuscular blockade with magnesium sulfate and nifedipine.", "tokenized_content": [2, 13148, 8767, 3, 15829, 9847, 1956, 13148, 8767, 1930, 25968, 18, 3]}, "items": [{"id": "p_2731", "content": "Magnesium Sulfate [SEP] A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclamps", "score": 1, "type": null, "tokenized_content": [2, 13148, 8767, 3, 43, 2858, 29500, 6561, 2251, 1966, 1925, 26572, 2031, 16, 43, 6258, 5931, 16, 1930, 1925, 15428, 24549, 14682, 1922, 1920, 2311, 1927, 2097, 17, 24712, 2523, 3]}]}
{"query": {"id": "q_2732", "content": "nifedipine [SEP] Neuromuscular blockade with magnesium sulfate and nifedipine.", "tokenized_content": [2, 25968, 3, 15829, 9847, 1956, 13148, 8767, 1930, 25968, 18, 3]}, "items": [{"id": "p_2732", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_2733", "content": "nifedipine [SEP] A patient who received tocolysis with nifedipine developed neuromuscular blockade after 500 mg of magnesium sulf", "tokenized_content": [2, 25968, 3, 43, 2774, 2746, 4004, 21682, 6892, 1956, 25968, 3530, 15829, 9847, 2256, 4599, 2786, 1927, 13148, 5141, 3]}, "items": [{"id": "p_2733", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_2734", "content": "neuromuscular blockade [SEP] A patient who received tocolysis with nifedipine developed neuromuscular blockade after 500 mg of magnesium sulfate was administered. This reacti", "tokenized_content": [2, 15829, 9847, 3, 43, 2774, 2746, 4004, 21682, 6892, 1956, 25968, 3530, 15829, 9847, 2256, 4599, 2786, 1927, 13148, 8767, 1982, 5254, 18, 2052, 9793, 1033, 3]}, "items": [{"id": "p_2734", "content": "Neuromuscular Manifestations [SEP] Signs and symptoms associated with diseases of the muscle, neuromuscular junction, or peripheral nerves.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15829, 10952, 3, 6879, 1930, 3601, 2458, 1956, 3902, 1927, 1920, 3760, 16, 15829, 6910, 16, 2014, 5009, 12014, 18, 3]}]}
{"query": {"id": "q_2735", "content": "magnesium sulfate [SEP] ith nifedipine developed neuromuscular blockade after 500 mg of magnesium sulfate was administered. This reaction demonstrates that nifedipine ca", "tokenized_content": [2, 13148, 8767, 3, 24737, 25968, 3530, 15829, 9847, 2256, 4599, 2786, 1927, 13148, 8767, 1982, 5254, 18, 2052, 3227, 7706, 1988, 25968, 2332, 3]}, "items": [{"id": "p_2735", "content": "Magnesium Sulfate [SEP] A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclamps", "score": 1, "type": null, "tokenized_content": [2, 13148, 8767, 3, 43, 2858, 29500, 6561, 2251, 1966, 1925, 26572, 2031, 16, 43, 6258, 5931, 16, 1930, 1925, 15428, 24549, 14682, 1922, 1920, 2311, 1927, 2097, 17, 24712, 2523, 3]}]}
{"query": {"id": "q_2736", "content": "toxicity [SEP] ction demonstrates that nifedipine can seriously potentiate the toxicity of magnesium. Caution should be exercised when these two tocoly", "tokenized_content": [2, 5532, 3, 3369, 2001, 7706, 1988, 25968, 2112, 22713, 23350, 1920, 5532, 1927, 13148, 18, 12838, 3066, 1998, 27776, 2469, 2144, 2288, 21682, 26558, 3]}, "items": [{"id": "p_2736", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2737", "content": "magnesium [SEP] ith nifedipine developed neuromuscular blockade after 500 mg of magnesium sulfate was administered. This reaction demonstrates that nifed", "tokenized_content": [2, 13148, 3, 24737, 25968, 3530, 15829, 9847, 2256, 4599, 2786, 1927, 13148, 8767, 1982, 5254, 18, 2052, 3227, 7706, 1988, 25855, 3]}, "items": [{"id": "p_2737", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_2738", "content": "Ifosfamide [SEP] Ifosfamide continuous infusion without mesna. A phase I trial of a 14-day ", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2647, 1951, 6016, 16408, 1021, 4798, 7386, 2979, 4438, 2175, 18, 43, 3193, 51, 3046, 1927, 43, 2607, 17, 3007, 3]}, "items": [{"id": "p_2738", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_2739", "content": "mesna [SEP] Ifosfamide continuous infusion without mesna. A phase I trial of a 14-day cycle.", "tokenized_content": [2, 4438, 2175, 3, 2647, 1951, 6016, 16408, 1021, 4798, 7386, 2979, 4438, 2175, 18, 43, 3193, 51, 3046, 1927, 43, 2607, 17, 3007, 4048, 18, 3]}, "items": [{"id": "p_2739", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_2740", "content": "ifosfamide [SEP] Twenty patients received 27 courses of ifosfamide administered as a 24-hour continuous infusion for 14 days witho", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 7639, 2132, 4004, 3225, 12726, 1927, 2647, 1951, 6016, 16408, 1021, 5254, 1966, 43, 2686, 17, 6231, 4798, 7386, 1958, 2607, 3000, 1956, 1037, 3]}, "items": [{"id": "p_2740", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_2741", "content": "Mesna [SEP] ministered as a 24-hour continuous infusion for 14 days without Mesna. The goal of the study was to deliver a dose rate and total cum", "tokenized_content": [2, 4438, 2175, 3, 9696, 2156, 7752, 1966, 43, 2686, 17, 6231, 4798, 7386, 1958, 2607, 3000, 2979, 4438, 2175, 18, 1920, 6640, 1927, 1920, 2161, 1982, 1942, 3971, 43, 3253, 3]}, "items": [{"id": "p_2741", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_2742", "content": "hematuria [SEP]  and 550 mg/m2/d. Four patients developed transient microscopic hematuria at 400, 450, and 500 mg/m2/d. There were no instances of macros", "tokenized_content": [2, 30267, 3, 1930, 16685, 2786, 19, 6056, 19, 46, 18, 3006, 2132, 3530, 6809, 10372, 30267, 2019, 5805, 16, 11193, 16, 1930, 4599, 2786, 19, 6056, 19, 46, 18, 2276, 3]}, "items": [{"id": "p_2742", "content": "Hematuria [SEP] Presence of blood in the urine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30267, 3, 2990, 1927, 2877, 1922, 1920, 6960, 18, 3]}]}
{"query": {"id": "q_2743", "content": "toxicity [SEP] maturia. At 550 mg/m2/d, three patients experienced nonurologic toxicity; confusion (1), nausea (1), and Grade 2 leukopenia (1). The rec", "tokenized_content": [2, 5532, 3, 2888, 8754, 18, 2019, 16685, 2786, 19, 6056, 19, 46, 16, 2559, 2132, 6090, 2447, 18916, 22284, 1935, 5532, 31, 18272, 12, 21, 13, 16, 13759, 12, 21, 3]}, "items": [{"id": "p_2743", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2744", "content": "confusion [SEP] t 550 mg/m2/d, three patients experienced nonurologic toxicity; confusion (1), nausea (1), and Grade 2 leukopenia (1). The recommended do", "tokenized_content": [2, 18272, 3, 62, 16685, 2786, 19, 6056, 19, 46, 16, 2559, 2132, 6090, 2447, 18916, 22284, 1935, 5532, 31, 18272, 12, 21, 13, 16, 13759, 12, 21, 13, 16, 1930, 3]}, "items": [{"id": "p_2744", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_2745", "content": "nausea [SEP] three patients experienced nonurologic toxicity; confusion (1), nausea (1), and Grade 2 leukopenia (1). The recommended dose of 500 mg", "tokenized_content": [2, 13759, 3, 2559, 2132, 6090, 2447, 18916, 22284, 1935, 5532, 31, 18272, 12, 21, 13, 16, 13759, 12, 21, 13, 16, 1930, 4927, 22, 5104, 12903, 12, 21, 13, 18, 3]}, "items": [{"id": "p_2745", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_2746", "content": "leukopenia [SEP] ed nonurologic toxicity; confusion (1), nausea (1), and Grade 2 leukopenia (1). The recommended dose of 500 mg/m2/d delivers a total dose ", "tokenized_content": [2, 5104, 12903, 3, 3347, 2447, 18916, 22284, 1935, 5532, 31, 18272, 12, 21, 13, 16, 13759, 12, 21, 13, 16, 1930, 4927, 22, 5104, 12903, 12, 21, 13, 18, 1920, 3]}, "items": [{"id": "p_2746", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_2747", "content": "Myocardial infarction [SEP] Myocardial infarction in pregnancy associated with clomiphene citrate for ovulation i", "tokenized_content": [2, 6497, 8358, 3, 6497, 8358, 1922, 5284, 2458, 1956, 12596, 7395, 17616, 1021, 11599, 1958, 21496, 51, 3]}, "items": [{"id": "p_2747", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2748", "content": "clomiphene citrate [SEP] Myocardial infarction in pregnancy associated with clomiphene citrate for ovulation induction: a case report.", "tokenized_content": [2, 12596, 7395, 17616, 1021, 11599, 3, 6497, 8358, 1922, 5284, 2458, 1956, 12596, 7395, 17616, 1021, 11599, 1958, 21496, 4408, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2748", "content": "Clomiphene [SEP] A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that EN", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 43, 14051, 8033, 13183, 6334, 1024, 5873, 2912, 10533, 2154, 1977, 1925, 7940, 7829, 2014, 8151, 6362, 1990, 1920, 2758, 2960, 18, 4725, 1988, 2066, 3]}]}
{"query": {"id": "q_2749", "content": "Clomiphene citrate [SEP] BACKGROUND: Clomiphene citrate (CC) is commonly prescribed for ovulation induction. It is cons", "tokenized_content": [2, 12596, 7395, 17616, 1021, 11599, 3, 3872, 30, 12596, 7395, 17616, 1021, 11599, 12, 4928, 13, 1977, 5384, 9975, 1958, 21496, 4408, 18, 2176, 1977, 2134, 3]}, "items": [{"id": "p_2749", "content": "Clomiphene [SEP] A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that EN", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 43, 14051, 8033, 13183, 6334, 1024, 5873, 2912, 10533, 2154, 1977, 1925, 7940, 7829, 2014, 8151, 6362, 1990, 1920, 2758, 2960, 18, 4725, 1988, 2066, 3]}]}
{"query": {"id": "q_2750", "content": "CC [SEP] BACKGROUND: Clomiphene citrate (CC) is commonly prescribed for ovulation induction. It is consider", "tokenized_content": [2, 4928, 3, 3872, 30, 12596, 7395, 17616, 1021, 11599, 12, 4928, 13, 1977, 5384, 9975, 1958, 21496, 4408, 18, 2176, 1977, 2782, 3]}, "items": [{"id": "p_2750", "content": "Clomiphene [SEP] A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that EN", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 43, 14051, 8033, 13183, 6334, 1024, 5873, 2912, 10533, 2154, 1977, 1925, 7940, 7829, 2014, 8151, 6362, 1990, 1920, 2758, 2960, 18, 4725, 1988, 2066, 3]}]}
{"query": {"id": "q_2751", "content": "Thromboembolism [SEP] on induction. It is considered safe, with minimal side effects. Thromboembolism is a rare but life-threatening complication that has been repor", "tokenized_content": [2, 23821, 3, 1990, 4408, 18, 2176, 1977, 3311, 7672, 16, 1956, 6343, 4159, 2564, 18, 23821, 1977, 43, 5844, 2308, 3308, 17, 13281, 9388, 1988, 2258, 2252, 2424, 3]}, "items": [{"id": "p_2751", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_2752", "content": "coronary thrombosis [SEP] as been reported after ovulation induction with CC. Spontaneous coronary thrombosis or thromboembolism with subsequent clot lysis has been suggeste", "tokenized_content": [2, 5846, 11354, 3, 1966, 2252, 2568, 2256, 21496, 4408, 1956, 4928, 18, 6242, 5846, 11354, 2014, 23821, 1956, 4521, 15053, 8502, 2258, 2252, 3220, 1021, 3]}, "items": [{"id": "p_2752", "content": "Coronary Thrombosis [SEP] Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTIO", "score": 1, "type": null, "tokenized_content": [2, 5846, 11354, 3, 12441, 1927, 2877, 1922, 2967, 1927, 1920, 5846, 7208, 18, 1920, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 3868, 5029, 1942, 6497, 13389, 3940, 3]}]}
{"query": {"id": "q_2753", "content": "thromboembolism [SEP] ovulation induction with CC. Spontaneous coronary thrombosis or thromboembolism with subsequent clot lysis has been suggested as one of the mos", "tokenized_content": [2, 23821, 3, 21496, 4408, 1956, 4928, 18, 6242, 5846, 11354, 2014, 23821, 1956, 4521, 15053, 8502, 2258, 2252, 3978, 1966, 2340, 1927, 1920, 7500, 3]}, "items": [{"id": "p_2753", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_2754", "content": "myocardial infarction [SEP] ot lysis has been suggested as one of the most common causes of myocardial infarction (MI) during pregnancy, with a subsequently normal coronary angi", "tokenized_content": [2, 6497, 8358, 3, 7608, 8502, 2258, 2252, 3978, 1966, 2340, 1927, 1920, 2501, 3059, 5092, 1927, 6497, 8358, 12, 6519, 13, 2409, 5284, 16, 1956, 43, 5326, 2791, 5846, 4805, 3]}, "items": [{"id": "p_2754", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2755", "content": "MI [SEP] sted as one of the most common causes of myocardial infarction (MI) during pregnancy, with a subsequently normal coronary angiogra", "tokenized_content": [2, 6519, 3, 4780, 1007, 1966, 2340, 1927, 1920, 2501, 3059, 5092, 1927, 6497, 8358, 12, 6519, 13, 2409, 5284, 16, 1956, 43, 5326, 2791, 5846, 29220, 2299, 1019, 3]}, "items": [{"id": "p_2755", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2756", "content": "chest pain [SEP] recently received CC for ovulation induction and presented with chest pain. An electrocardiogram showed a lateral and anterior wall myocar", "tokenized_content": [2, 8475, 3594, 3, 3998, 4004, 4928, 1958, 21496, 4408, 1930, 3549, 1956, 8475, 3594, 18, 1925, 22477, 2594, 43, 5347, 1930, 5477, 4821, 15924, 15339, 3]}, "items": [{"id": "p_2756", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_2757", "content": "radiation injury [SEP] rmal. At the time of admission, the patient was at high risk of radiation injury to the fetus, so a coronary angiogram was postponed until the s", "tokenized_content": [2, 5442, 4047, 3, 10625, 1923, 18, 2019, 1920, 2367, 1927, 7682, 16, 1920, 2774, 1982, 2019, 2149, 2565, 1927, 5442, 4047, 1942, 1920, 15722, 16, 2577, 43, 5846, 29220, 20087, 3]}, "items": [{"id": "p_2757", "content": "Radiation Injuries [SEP] Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5442, 8209, 3, 13635, 2564, 1927, 2447, 17, 3599, 3395, 1942, 19955, 2014, 2447, 17, 19955, 5442, 1922, 14976, 18, 3]}]}
{"query": {"id": "q_2758", "content": "Thrombosis [SEP] ng a possible association between CC and myocardial infarction. Thrombosis might be a rare but hazardous complication of CC. Given this li", "tokenized_content": [2, 11354, 3, 4375, 43, 3216, 3279, 2192, 4928, 1930, 6497, 8358, 18, 11354, 3284, 1998, 43, 5844, 2308, 22194, 9388, 1927, 4928, 18, 3258, 2052, 2336, 3]}, "items": [{"id": "p_2758", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_2759", "content": "cholangitis [SEP] Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report o", "tokenized_content": [2, 17657, 3600, 3, 5746, 29525, 4870, 1930, 17657, 3600, 2712, 1942, 2815, 17, 2576, 3037, 18986, 3181, 30, 1925, 16740, 3809, 57, 3]}, "items": [{"id": "p_2759", "content": "Cholangitis [SEP] Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17657, 3600, 3, 4531, 1927, 1920, 13210, 15154, 2433, 12, 9619, 19277, 13, 31, 22323, 16, 29086, 16, 2014, 2321, 18, 3]}]}
{"query": {"id": "q_2760", "content": "phenobarbital [SEP] Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients.", "tokenized_content": [2, 3037, 18986, 3, 5746, 29525, 4870, 1930, 17657, 3600, 2712, 1942, 2815, 17, 2576, 3037, 18986, 3181, 30, 1925, 16740, 3809, 1927, 2288, 2132, 18, 3]}, "items": [{"id": "p_2760", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_2761", "content": "Phenobarbital [SEP] Phenobarbital (PB) has a reputation for safety, and it is commonly believed t", "tokenized_content": [2, 3037, 18986, 3, 3037, 18986, 12, 5242, 13, 2258, 43, 3073, 9897, 1958, 5407, 16, 1930, 2176, 1977, 5384, 9283, 62, 3]}, "items": [{"id": "p_2761", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_2762", "content": "PB [SEP] Phenobarbital (PB) has a reputation for safety, and it is commonly believed that ", "tokenized_content": [2, 5242, 3, 3037, 18986, 12, 5242, 13, 2258, 43, 3073, 9897, 1958, 5407, 16, 1930, 2176, 1977, 5384, 9283, 1988, 3]}, "items": [{"id": "p_2762", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_2763", "content": "liver disease [SEP]  not indicate or predict the development of significant chronic liver disease. Here we report of two adult patients with a long history of ep", "tokenized_content": [2, 3568, 2573, 3, 2084, 3579, 2014, 5660, 1920, 2740, 1927, 2228, 3724, 3568, 2573, 18, 3410, 2038, 3809, 1927, 2288, 4160, 2132, 1956, 43, 2815, 4403, 1927, 2630, 3]}, "items": [{"id": "p_2763", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2764", "content": "epilepsy [SEP] se. Here we report of two adult patients with a long history of epilepsy treated with PB who died suddenly: one as consequence of cardia", "tokenized_content": [2, 9741, 3, 2058, 18, 3410, 2038, 3809, 1927, 2288, 4160, 2132, 1956, 43, 2815, 4403, 1927, 9741, 2868, 1956, 5242, 2746, 8545, 12446, 1954, 30, 2340, 1966, 7749, 1927, 3215, 3]}, "items": [{"id": "p_2764", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2765", "content": "cardiac arrest [SEP] ilepsy treated with PB who died suddenly: one as consequence of cardiac arrest, the other of acute bronchopneumonia. At autopsy, analysis of l", "tokenized_content": [2, 4435, 8048, 3, 9940, 9196, 2868, 1956, 5242, 2746, 8545, 12446, 1954, 30, 2340, 1966, 7749, 1927, 4435, 8048, 16, 1920, 2303, 1927, 3939, 7777, 2011, 5926, 6114, 18, 2019, 3]}, "items": [{"id": "p_2765", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_2766", "content": "bronchopneumonia [SEP] denly: one as consequence of cardiac arrest, the other of acute bronchopneumonia. At autopsy, analysis of liver parenchyma revealed rich portal ", "tokenized_content": [2, 7777, 2011, 5926, 6114, 3, 4533, 1954, 30, 2340, 1966, 7749, 1927, 4435, 8048, 16, 1920, 2303, 1927, 3939, 7777, 2011, 5926, 6114, 18, 2019, 16740, 16, 2333, 1927, 3568, 3]}, "items": [{"id": "p_2766", "content": "Bronchopneumonia [SEP] Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLE", "score": 1, "type": null, "tokenized_content": [2, 7777, 2011, 5926, 6114, 3, 4531, 1927, 1920, 3614, 15214, 1988, 1977, 2458, 1956, 28938, 16, 5394, 5884, 28560, 3957, 2037, 4262, 30149, 1021, 3]}]}
{"query": {"id": "q_2767", "content": "necrosis [SEP]  eosinophil and monocyte cells, associated with several foci of necrosis surrounded by a hard ring of non-specific granulomatous tissue.", "tokenized_content": [2, 7476, 3, 11510, 1930, 12064, 2094, 16, 2458, 1956, 2980, 10334, 1927, 7476, 16006, 2007, 43, 6986, 6335, 1927, 2447, 17, 2487, 26676, 2960, 18, 3]}, "items": [{"id": "p_2767", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_2768", "content": "liver damage [SEP]  Our findings illustrate that PB may be associated with chronic liver damage, which may lead to more serious and deleterious consequences. F", "tokenized_content": [2, 3568, 4293, 3, 2342, 3056, 11197, 1988, 5242, 2278, 1998, 2458, 1956, 3724, 3568, 4293, 16, 2154, 2278, 2949, 1942, 2253, 7433, 1930, 12524, 7080, 18, 48, 3]}, "items": [{"id": "p_2768", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2769", "content": "chronic hepatic enzyme dysfunction [SEP] entity in the differential diagnosis of PB-related asymptomatic chronic hepatic enzyme dysfunction.", "tokenized_content": [2, 3724, 6095, 4113, 5273, 3, 14866, 1922, 1920, 5611, 3574, 1927, 5242, 17, 2712, 9978, 3724, 6095, 4113, 5273, 18, 3]}, "items": [{"id": "p_2769", "content": "Drug-Induced Liver Injury, Chronic [SEP] Liver disease lasting six months or more, caused by an adverse drug effect. The adverse effect may result from a direct toxic ef", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 16, 3724, 3, 3568, 2573, 11671, 3798, 3221, 2014, 2253, 16, 4189, 2007, 1925, 5246, 2838, 2495, 18, 1920, 5246, 2495, 2278, 3211, 2037, 43, 3083, 6161, 8485, 3]}]}
{"query": {"id": "q_2770", "content": "Ethambutol [SEP] Ethambutol-associated optic neuropathy.", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 3293, 6739, 1984, 1945, 17, 2458, 10109, 13177, 18, 3]}, "items": [{"id": "p_2770", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_2771", "content": "optic neuropathy [SEP] Ethambutol-associated optic neuropathy.", "tokenized_content": [2, 10109, 13177, 3, 3293, 6739, 1984, 1945, 17, 2458, 10109, 13177, 18, 3]}, "items": [{"id": "p_2771", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_2772", "content": "Ethambutol [SEP] INTRODUCTION: Ethambutol is used in the treatment of tuberculosis, which is still preval", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 6935, 30, 3293, 6739, 1984, 1945, 1977, 2251, 1922, 1920, 2311, 1927, 8449, 16, 2154, 1977, 3974, 3778, 3]}, "items": [{"id": "p_2772", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_2773", "content": "tuberculosis [SEP] INTRODUCTION: Ethambutol is used in the treatment of tuberculosis, which is still prevalent in Southeast Asia, and can be associa", "tokenized_content": [2, 8449, 3, 6935, 30, 3293, 6739, 1984, 1945, 1977, 2251, 1922, 1920, 2311, 1927, 8449, 16, 2154, 1977, 3974, 8942, 1922, 20141, 11624, 16, 1930, 2112, 1998, 2293, 1019, 3]}, "items": [{"id": "p_2773", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_2774", "content": "visual loss [SEP] evalent in Southeast Asia, and can be associated with permanent visual loss. We report 3 cases which presented with bitemporal hemianopia. ", "tokenized_content": [2, 3737, 3257, 3, 2180, 16896, 1922, 20141, 11624, 16, 1930, 2112, 1998, 2458, 1956, 11047, 3737, 3257, 18, 2038, 3809, 23, 2919, 2154, 3549, 1956, 21095, 6588, 6277, 28881, 9286, 3]}, "items": [{"id": "p_2774", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2775", "content": "bitemporal hemianopia [SEP] h permanent visual loss. We report 3 cases which presented with bitemporal hemianopia. CLINICAL PICTURE: Three patients with ethambutol-associated to", "tokenized_content": [2, 21095, 6588, 6277, 28881, 9286, 10984, 1019, 3, 50, 11047, 3737, 3257, 18, 2038, 3809, 23, 2919, 2154, 3549, 1956, 21095, 6588, 6277, 28881, 9286, 10984, 1019, 18, 2535, 10213, 3]}, "items": [{"id": "p_2775", "content": "Hemianopsia [SEP] Partial or complete loss of vision in one half of the visual field(s) of one or both eyes. Subtypes include altitudinal hemianop", "score": 1, "type": null, "tokenized_content": [2, 28881, 9286, 14149, 3, 5740, 2014, 4080, 3257, 1927, 9266, 1922, 2340, 4768, 1927, 1920, 3737, 3559, 12, 61, 13, 1927, 2340, 2014, 2321, 7127, 18, 8160, 3951, 8387, 5629, 2526, 28881, 9286, 1034, 3]}]}
{"query": {"id": "q_2776", "content": "ethambutol [SEP] th bitemporal hemianopia. CLINICAL PICTURE: Three patients with ethambutol-associated toxic optic neuropathy are described. All 3 patients", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1913, 21095, 6588, 6277, 28881, 9286, 10984, 1019, 18, 2535, 10213, 30, 2559, 2132, 1956, 3293, 6739, 1984, 1945, 17, 2458, 6161, 10109, 13177, 2032, 3]}, "items": [{"id": "p_2776", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_2777", "content": "optic neuropathy [SEP] INICAL PICTURE: Three patients with ethambutol-associated toxic optic neuropathy are described. All 3 patients had loss of central visual acuity", "tokenized_content": [2, 10109, 13177, 3, 1922, 2046, 10213, 30, 2559, 2132, 1956, 3293, 6739, 1984, 1945, 17, 2458, 6161, 10109, 13177, 2032, 2910, 18, 2136, 23, 2132, 2430, 3257, 1927, 4101, 3737, 3]}, "items": [{"id": "p_2777", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_2778", "content": "loss of central visual acuity, colour vision (Ishihara) and visual field [SEP] ciated toxic optic neuropathy are described. All 3 patients had loss of central visual acuity, colour vision (Ishihara) and visual field. The visual field loss had a bitemporal flavour, suggesting inv", "tokenized_content": [2, 3257, 1927, 4101, 3737, 12320, 16, 10917, 9266, 12, 17633, 4442, 9041, 13, 1930, 3737, 3559, 3, 24748, 2013, 6161, 10109, 13177, 2032, 2910, 18, 2136, 23, 2132, 2430, 3257, 3]}, "items": [{"id": "p_2778", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2779", "content": "visual field loss [SEP] l visual acuity, colour vision (Ishihara) and visual field. The visual field loss had a bitemporal flavour, suggesting involvement of the optic c", "tokenized_content": [2, 3737, 3559, 3257, 3, 54, 3737, 12320, 16, 10917, 9266, 12, 17633, 4442, 9041, 13, 1930, 3737, 3559, 18, 1920, 3737, 3559, 3257, 2430, 43, 21095, 6588, 6277, 7732, 2257, 3]}, "items": [{"id": "p_2779", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2780", "content": "loss of visual function [SEP] tic discs were pale. OUTCOME: All 3 patients had some permanent loss of visual function. CONCLUSIONS: Ethambutol usage is associated with permanent vis", "tokenized_content": [2, 3257, 1927, 3737, 2347, 3, 18298, 16380, 1985, 16222, 18, 3924, 30, 2136, 23, 2132, 2430, 2673, 11047, 3257, 1927, 3737, 2347, 18, 4355, 30, 3293, 6739, 1984, 1945, 10070, 3]}, "items": [{"id": "p_2780", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2781", "content": "nimesulide [SEP] Tolerability of nimesulide and paracetamol in patients with NSAID-induced urticaria/angioe", "tokenized_content": [2, 17709, 1918, 13004, 3695, 3, 17934, 1927, 17709, 1918, 13004, 3695, 1930, 27021, 1922, 2132, 1956, 24194, 17, 2719, 27986, 6148, 19, 29220, 1021, 3]}, "items": [{"id": "p_2781", "content": "nimesulide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17709, 1918, 13004, 3695, 3, 3]}]}
{"query": {"id": "q_2782", "content": "paracetamol [SEP] Tolerability of nimesulide and paracetamol in patients with NSAID-induced urticaria/angioedema.", "tokenized_content": [2, 27021, 3, 17934, 1927, 17709, 1918, 13004, 3695, 1930, 27021, 1922, 2132, 1956, 24194, 17, 2719, 27986, 6148, 19, 29220, 16670, 18, 3]}, "items": [{"id": "p_2782", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2783", "content": "NSAID [SEP] Tolerability of nimesulide and paracetamol in patients with NSAID-induced urticaria/angioedema.", "tokenized_content": [2, 24194, 3, 17934, 1927, 17709, 1918, 13004, 3695, 1930, 27021, 1922, 2132, 1956, 24194, 17, 2719, 27986, 6148, 19, 29220, 16670, 18, 3]}, "items": [{"id": "p_2783", "content": "Anti-Inflammatory Agents, Non-Steroidal [SEP] Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipy", "score": 1, "type": null, "tokenized_content": [2, 2246, 17, 3769, 4820, 16, 2447, 17, 24932, 3, 2246, 17, 3769, 4820, 1988, 2032, 2447, 17, 24932, 1922, 4899, 18, 1922, 2459, 1942, 2246, 17, 3769, 7728, 16, 2611, 2162, 14501, 16, 2246, 13976, 3]}]}
{"query": {"id": "q_2784", "content": "urticaria [SEP] ty of nimesulide and paracetamol in patients with NSAID-induced urticaria/angioedema.", "tokenized_content": [2, 27986, 6148, 3, 6227, 1927, 17709, 1918, 13004, 3695, 1930, 27021, 1922, 2132, 1956, 24194, 17, 2719, 27986, 6148, 19, 29220, 16670, 18, 3]}, "items": [{"id": "p_2784", "content": "Urticaria [SEP] A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability", "score": 1, "type": null, "tokenized_content": [2, 27986, 6148, 3, 43, 4541, 3227, 1927, 1920, 4407, 4378, 2007, 23349, 1930, 8372, 1923, 3337, 2810, 1942, 6579, 2760, 1927, 4541, 8828, 3]}]}
{"query": {"id": "q_2785", "content": "angioedema [SEP] sulide and paracetamol in patients with NSAID-induced urticaria/angioedema.", "tokenized_content": [2, 29220, 16670, 3, 9596, 2261, 1930, 27021, 1922, 2132, 1956, 24194, 17, 2719, 27986, 6148, 19, 29220, 16670, 18, 3]}, "items": [{"id": "p_2785", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2786", "content": "nimesulide [SEP] Previous studies evaluated the tolerance of nimesulide and paracetamol in subjects with cutaneous, respiratory and ana", "tokenized_content": [2, 17709, 1918, 13004, 3695, 3, 2555, 2351, 3747, 1920, 6555, 1927, 17709, 1918, 13004, 3695, 1930, 27021, 1922, 3297, 1956, 11276, 16, 5481, 1930, 7381, 3]}, "items": [{"id": "p_2786", "content": "nimesulide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17709, 1918, 13004, 3695, 3, 3]}]}
{"query": {"id": "q_2787", "content": "paracetamol [SEP] Previous studies evaluated the tolerance of nimesulide and paracetamol in subjects with cutaneous, respiratory and anaphylactoid react", "tokenized_content": [2, 27021, 3, 2555, 2351, 3747, 1920, 6555, 1927, 17709, 1918, 13004, 3695, 1930, 27021, 1922, 3297, 1956, 11276, 16, 5481, 1930, 21219, 2131, 2642, 9793, 3]}, "items": [{"id": "p_2787", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2788", "content": "nonsteroidal anti-inflammatory drugs [SEP] h cutaneous, respiratory and anaphylactoid reactions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). In this study we investigated tolerability and reliab", "tokenized_content": [2, 29413, 2246, 17, 3769, 4195, 3, 50, 11276, 16, 5481, 1930, 21219, 2131, 2642, 5298, 2719, 2007, 29413, 2246, 17, 3769, 4195, 12, 17739, 13, 18, 1922, 2052, 2161, 2038, 3]}, "items": [{"id": "p_2788", "content": "Anti-Inflammatory Agents, Non-Steroidal [SEP] Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipy", "score": 1, "type": null, "tokenized_content": [2, 2246, 17, 3769, 4820, 16, 2447, 17, 24932, 3, 2246, 17, 3769, 4820, 1988, 2032, 2447, 17, 24932, 1922, 4899, 18, 1922, 2459, 1942, 2246, 17, 3769, 7728, 16, 2611, 2162, 14501, 16, 2246, 13976, 3]}]}
{"query": {"id": "q_2789", "content": "NSAIDs [SEP] toid reactions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). In this study we investigated tolerability and reliability of", "tokenized_content": [2, 17739, 3, 1942, 1960, 5298, 2719, 2007, 29413, 2246, 17, 3769, 4195, 12, 17739, 13, 18, 1922, 2052, 2161, 2038, 3845, 17934, 1930, 7328, 1927, 3]}, "items": [{"id": "p_2789", "content": "Anti-Inflammatory Agents, Non-Steroidal [SEP] Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipy", "score": 1, "type": null, "tokenized_content": [2, 2246, 17, 3769, 4820, 16, 2447, 17, 24932, 3, 2246, 17, 3769, 4820, 1988, 2032, 2447, 17, 24932, 1922, 4899, 18, 1922, 2459, 1942, 2246, 17, 3769, 7728, 16, 2611, 2162, 14501, 16, 2246, 13976, 3]}]}
{"query": {"id": "q_2790", "content": "NSAID [SEP] toid reactions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). In this study we investigated tolerability and reliability o", "tokenized_content": [2, 24194, 3, 1942, 1960, 5298, 2719, 2007, 29413, 2246, 17, 3769, 4195, 12, 17739, 13, 18, 1922, 2052, 2161, 2038, 3845, 17934, 1930, 7328, 57, 3]}, "items": [{"id": "p_2790", "content": "Anti-Inflammatory Agents, Non-Steroidal [SEP] Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipy", "score": 1, "type": null, "tokenized_content": [2, 2246, 17, 3769, 4820, 16, 2447, 17, 24932, 3, 2246, 17, 3769, 4820, 1988, 2032, 2447, 17, 24932, 1922, 4899, 18, 1922, 2459, 1942, 2246, 17, 3769, 7728, 16, 2611, 2162, 14501, 16, 2246, 13976, 3]}]}
{"query": {"id": "q_2791", "content": "urticaria [SEP] ents with an exclusive well-documented history of NSAID-induced urticaria/angioedema. Furthermore, we evaluated whether some factors have", "tokenized_content": [2, 27986, 6148, 3, 8496, 1036, 1956, 1925, 13132, 2486, 17, 6974, 4403, 1927, 24194, 17, 2719, 27986, 6148, 19, 29220, 16670, 18, 3677, 16, 2038, 3747, 3053, 2673, 2790, 2162, 3]}, "items": [{"id": "p_2791", "content": "Urticaria [SEP] A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability", "score": 1, "type": null, "tokenized_content": [2, 27986, 6148, 3, 43, 4541, 3227, 1927, 1920, 4407, 4378, 2007, 23349, 1930, 8372, 1923, 3337, 2810, 1942, 6579, 2760, 1927, 4541, 8828, 3]}]}
{"query": {"id": "q_2792", "content": "angioedema [SEP] an exclusive well-documented history of NSAID-induced urticaria/angioedema. Furthermore, we evaluated whether some factors have the potent", "tokenized_content": [2, 29220, 16670, 3, 1925, 13132, 2486, 17, 6974, 4403, 1927, 24194, 17, 2719, 27986, 6148, 19, 29220, 16670, 18, 3677, 16, 2038, 3747, 3053, 2673, 2790, 2162, 1920, 6828, 3]}, "items": [{"id": "p_2792", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_2793", "content": "verapamil [SEP] Effects of verapamil on atrial fibrillation and its electrophysiological determinant", "tokenized_content": [2, 23300, 3, 2564, 1927, 23300, 1990, 9224, 13671, 1930, 2496, 13189, 12483, 3]}, "items": [{"id": "p_2793", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2794", "content": "atrial fibrillation [SEP] Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs.", "tokenized_content": [2, 9224, 13671, 3, 2564, 1927, 23300, 1990, 9224, 13671, 1930, 2496, 13189, 9873, 1922, 7894, 18, 3]}, "items": [{"id": "p_2794", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2795", "content": "Atrial tachycardia [SEP] BACKGROUND: Atrial tachycardia-induced remodeling promotes the occurrence and maintenance of a", "tokenized_content": [2, 9224, 17397, 3, 3872, 30, 9224, 17397, 17, 2719, 8378, 7383, 1920, 6564, 1930, 6291, 1927, 43, 3]}, "items": [{"id": "p_2795", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_2796", "content": "atrial fibrillation [SEP] a-induced remodeling promotes the occurrence and maintenance of atrial fibrillation (AF) and decreases L-type Ca(2+) current. There is also a clini", "tokenized_content": [2, 9224, 13671, 3, 43, 17, 2719, 8378, 7383, 1920, 6564, 1930, 6291, 1927, 9224, 13671, 12, 2221, 13, 1930, 6386, 54, 17, 2601, 2332, 12, 22, 15, 13, 3214, 18, 3]}, "items": [{"id": "p_2796", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2797", "content": "AF [SEP] promotes the occurrence and maintenance of atrial fibrillation (AF) and decreases L-type Ca(2+) current. There is also a clinical ", "tokenized_content": [2, 2221, 3, 7383, 1920, 6564, 1930, 6291, 1927, 9224, 13671, 12, 2221, 13, 1930, 6386, 54, 17, 2601, 2332, 12, 22, 15, 13, 3214, 18, 2276, 1977, 2222, 43, 2535, 3]}, "items": [{"id": "p_2797", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2798", "content": "Ca [SEP] nd maintenance of atrial fibrillation (AF) and decreases L-type Ca(2+) current. There is also a clinical suggestion that acute L-t", "tokenized_content": [2, 2332, 3, 8026, 6291, 1927, 9224, 13671, 12, 2221, 13, 1930, 6386, 54, 17, 2601, 2332, 12, 22, 15, 13, 3214, 18, 2276, 1977, 2222, 43, 2535, 17848, 1988, 3939, 3]}, "items": [{"id": "p_2798", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2799", "content": "verapamil [SEP] sms of AF promotion by Ca(2+) channel blockers, we administered verapamil to morphine-chloralose anesthetized dogs. Diltiazem was used as", "tokenized_content": [2, 23300, 3, 21646, 1927, 2221, 10693, 2007, 2332, 12, 22, 15, 13, 4999, 13628, 16, 2038, 5254, 23300, 1942, 11553, 17, 4891, 20807, 4127, 12137, 7894, 18, 4333, 11574, 6931, 3]}, "items": [{"id": "p_2799", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2800", "content": "morphine [SEP] motion by Ca(2+) channel blockers, we administered verapamil to morphine-chloralose anesthetized dogs. Diltiazem was used as a compariso", "tokenized_content": [2, 11553, 3, 6269, 2007, 2332, 12, 22, 15, 13, 4999, 13628, 16, 2038, 5254, 23300, 1942, 11553, 17, 4891, 20807, 4127, 12137, 7894, 18, 4333, 11574, 6931, 1035, 1982, 2251, 3]}, "items": [{"id": "p_2800", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_2801", "content": "chloralose [SEP]  Ca(2+) channel blockers, we administered verapamil to morphine-chloralose anesthetized dogs. Diltiazem was used as a comparison drug and ", "tokenized_content": [2, 4891, 20807, 4127, 3, 2332, 12, 22, 15, 13, 4999, 13628, 16, 2038, 5254, 23300, 1942, 11553, 17, 4891, 20807, 4127, 12137, 7894, 18, 4333, 11574, 6931, 1035, 1982, 2251, 3]}, "items": [{"id": "p_2801", "content": "Chloralose [SEP] A derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most co", "score": 1, "type": null, "tokenized_content": [2, 4891, 20807, 4127, 3, 43, 10533, 1927, 4891, 1923, 27864, 1988, 1982, 2251, 1966, 43, 28514, 2308, 2258, 2252, 8403, 2007, 20404, 1930, 2253, 3655, 4195, 18, 2496, 2501, 2081, 3]}]}
{"query": {"id": "q_2802", "content": "Diltiazem [SEP] dministered verapamil to morphine-chloralose anesthetized dogs. Diltiazem was used as a comparison drug and autonomic blockade with atrop", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 3931, 15472, 3188, 23300, 1942, 11553, 17, 4891, 20807, 4127, 12137, 7894, 18, 4333, 11574, 6931, 1035, 1982, 2251, 1966, 43, 3723, 2838, 1930, 13725, 3]}, "items": [{"id": "p_2802", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_2803", "content": "atropine [SEP] iazem was used as a comparison drug and autonomic blockade with atropine and nadolol was applied in some experiments. Epicardial mapping", "tokenized_content": [2, 24031, 3, 11640, 6931, 1035, 1982, 2251, 1966, 43, 3723, 2838, 1930, 13725, 9847, 1956, 24031, 1930, 6577, 23646, 1982, 3730, 1922, 2673, 3144, 18, 22568, 7084, 3]}, "items": [{"id": "p_2803", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_2804", "content": "nadolol [SEP] d as a comparison drug and autonomic blockade with atropine and nadolol was applied in some experiments. Epicardial mapping with 240 ep", "tokenized_content": [2, 6577, 23646, 3, 46, 1966, 43, 3723, 2838, 1930, 13725, 9847, 1956, 24031, 1930, 6577, 23646, 1982, 3730, 1922, 2673, 3144, 18, 22568, 7084, 1956, 12075, 2630, 3]}, "items": [{"id": "p_2804", "content": "Nadolol [SEP] A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pe", "score": 1, "type": null, "tokenized_content": [2, 6577, 23646, 3, 43, 2447, 17, 5328, 4666, 17, 13672, 8151, 1956, 43, 2815, 4768, 17, 3308, 16, 2251, 1922, 5321, 2573, 1942, 2297, 16934, 16, 16961, 2737, 3]}]}
{"query": {"id": "q_2805", "content": "Verapamil [SEP]  electrodes was used to evaluate activation during AF. RESULTS: Verapamil caused AF promotion in six dogs, increasing mean duration of AF", "tokenized_content": [2, 23300, 3, 9115, 1982, 2251, 1942, 4323, 2936, 2409, 2221, 18, 2274, 30, 23300, 4189, 2221, 10693, 1922, 3798, 7894, 16, 3605, 2667, 4392, 1927, 2221, 3]}, "items": [{"id": "p_2805", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2806", "content": "diltiazem [SEP] , rather than decreasing, refractoriness. Neither verapamil nor diltiazem affected atrial conduction in the presence of autonomic blockad", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 16, 4356, 2254, 7742, 16, 10487, 14258, 1979, 18, 7132, 23300, 3990, 4333, 11574, 6931, 1035, 4218, 9224, 12382, 1922, 1920, 2990, 1927, 13725, 3367, 3]}, "items": [{"id": "p_2806", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_2807", "content": "Hypotension [SEP] Hypotension, bradycardia, and asystole after high-dose intravenous methylpr", "tokenized_content": [2, 16453, 3, 16453, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 2149, 17, 3253, 7307, 4963, 2047, 3]}, "items": [{"id": "p_2807", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2808", "content": "bradycardia [SEP] Hypotension, bradycardia, and asystole after high-dose intravenous methylprednisolone in", "tokenized_content": [2, 26192, 3, 16453, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 2149, 17, 3253, 7307, 30087, 1922, 3]}, "items": [{"id": "p_2808", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2809", "content": "asystole [SEP] Hypotension, bradycardia, and asystole after high-dose intravenous methylprednisolone in a monitored p", "tokenized_content": [2, 1966, 2298, 2456, 3, 16453, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 2149, 17, 3253, 7307, 30087, 1922, 43, 7027, 58, 3]}, "items": [{"id": "p_2809", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_2810", "content": "methylprednisolone [SEP] otension, bradycardia, and asystole after high-dose intravenous methylprednisolone in a monitored patient.", "tokenized_content": [2, 30087, 3, 7608, 3212, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 2149, 17, 3253, 7307, 30087, 1922, 43, 7027, 2774, 18, 3]}, "items": [{"id": "p_2810", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_2811", "content": "hypotension [SEP] We report a case of hypotension, bradycardia, and asystole after intravenous administration of ", "tokenized_content": [2, 16453, 3, 2038, 3809, 43, 3087, 1927, 16453, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 7307, 4183, 1927, 3]}, "items": [{"id": "p_2811", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2812", "content": "bradycardia [SEP] We report a case of hypotension, bradycardia, and asystole after intravenous administration of high-dose met", "tokenized_content": [2, 26192, 3, 2038, 3809, 43, 3087, 1927, 16453, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 7307, 4183, 1927, 2149, 17, 3253, 2130, 3]}, "items": [{"id": "p_2812", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2813", "content": "asystole [SEP] We report a case of hypotension, bradycardia, and asystole after intravenous administration of high-dose methylprednisolon", "tokenized_content": [2, 1966, 2298, 2456, 3, 2038, 3809, 43, 3087, 1927, 16453, 16, 26192, 16, 1930, 1966, 2298, 2456, 2256, 7307, 4183, 1927, 2149, 17, 3253, 29732, 26644, 3]}, "items": [{"id": "p_2813", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_2814", "content": "methylprednisolone [SEP] dia, and asystole after intravenous administration of high-dose methylprednisolone in a 73-year-old patient who underwent electrocardiographic (EC", "tokenized_content": [2, 30087, 3, 25141, 16, 1930, 1966, 2298, 2456, 2256, 7307, 4183, 1927, 2149, 17, 3253, 30087, 1922, 43, 5356, 17, 2476, 17, 4156, 2774, 2746, 5468, 15894, 4158, 12, 3270, 3]}, "items": [{"id": "p_2814", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_2815", "content": "ischemic [SEP] (ECG) monitoring throughout the episode. There was a history of ischemic cardiac disease 9 years earlier. The patient was admitted with ", "tokenized_content": [2, 7427, 3, 12, 11497, 13, 5378, 5264, 1920, 11631, 18, 2276, 1982, 43, 4403, 1927, 7427, 4435, 2573, 29, 2739, 5556, 18, 1920, 2774, 1982, 9723, 1956, 3]}, "items": [{"id": "p_2815", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_2816", "content": "cardiac disease [SEP] itoring throughout the episode. There was a history of ischemic cardiac disease 9 years earlier. The patient was admitted with a pulmonary-rena", "tokenized_content": [2, 4435, 2573, 3, 21384, 8641, 5264, 1920, 11631, 18, 2276, 1982, 43, 4403, 1927, 7427, 4435, 2573, 29, 2739, 5556, 18, 1920, 2774, 1982, 9723, 1956, 43, 5352, 17, 3866, 3]}, "items": [{"id": "p_2816", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_2817", "content": "pulmonary-renal syndrome [SEP] ardiac disease 9 years earlier. The patient was admitted with a pulmonary-renal syndrome with hemoptysis, rapidly progressive renal failure, and hypoxem", "tokenized_content": [2, 5352, 17, 4604, 4741, 3, 2245, 7408, 1948, 2573, 29, 2739, 5556, 18, 1920, 2774, 1982, 9723, 1956, 43, 5352, 17, 4604, 4741, 1956, 3243, 3460, 4662, 16, 6221, 7529, 3]}, "items": [{"id": "p_2817", "content": "Rapidly progressive glomerulonephritis with pulmonary hemorrhage [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6221, 7529, 27057, 1956, 5352, 10489, 3, 3]}]}
{"query": {"id": "q_2818", "content": "hemoptysis [SEP] . The patient was admitted with a pulmonary-renal syndrome with hemoptysis, rapidly progressive renal failure, and hypoxemia that required", "tokenized_content": [2, 3243, 3460, 4662, 3, 18, 1920, 2774, 1982, 9723, 1956, 43, 5352, 17, 4604, 4741, 1956, 3243, 3460, 4662, 16, 6221, 7529, 4604, 4574, 16, 1930, 29881, 1988, 3414, 3]}, "items": [{"id": "p_2818", "content": "Hemoptysis [SEP] Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung paren", "score": 1, "type": null, "tokenized_content": [2, 3243, 3460, 4662, 3, 6324, 6695, 2014, 15776, 3519, 1941, 1927, 2877, 14391, 2037, 2967, 3131, 1927, 1920, 5481, 6482, 16, 5394, 2037, 10489, 1922, 1920, 3614, 2096, 1917, 3]}]}
{"query": {"id": "q_2819", "content": "renal failure [SEP] a pulmonary-renal syndrome with hemoptysis, rapidly progressive renal failure, and hypoxemia that required mechanical ventilation in the inte", "tokenized_content": [2, 4604, 4574, 3, 43, 5352, 17, 4604, 4741, 1956, 3243, 3460, 4662, 16, 6221, 7529, 4604, 4574, 16, 1930, 29881, 1988, 3414, 5821, 10198, 1922, 1920, 21318, 3]}, "items": [{"id": "p_2819", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_2820", "content": "hypoxemia [SEP] yndrome with hemoptysis, rapidly progressive renal failure, and hypoxemia that required mechanical ventilation in the intensive care unit", "tokenized_content": [2, 29881, 3, 67, 10249, 4191, 1956, 3243, 3460, 4662, 16, 6221, 7529, 4604, 4574, 16, 1930, 29881, 1988, 3414, 5821, 10198, 1922, 1920, 8100, 2859, 5344, 3]}, "items": [{"id": "p_2820", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_2821", "content": "ventricular arrhythmia [SEP] ered cardiac rhythm. The ECG showed a junctional rhythm without ventricular arrhythmia. This study reviews the current proposed mechanisms of sudden d", "tokenized_content": [2, 6493, 18346, 3, 22561, 1007, 4435, 11529, 18, 1920, 11497, 2594, 43, 21226, 11529, 2979, 6493, 18346, 18, 2052, 2161, 8617, 1920, 3214, 4211, 3531, 1927, 12446, 46, 3]}, "items": [{"id": "p_2821", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2822", "content": "sudden death [SEP] rhythmia. This study reviews the current proposed mechanisms of sudden death after a high dose of intravenous methylprednisolone (IVMP). The", "tokenized_content": [2, 12446, 3539, 3, 11529, 2126, 18, 2052, 2161, 8617, 1920, 3214, 4211, 3531, 1927, 12446, 3539, 2256, 43, 2149, 3253, 1927, 7307, 30087, 12, 4370, 6588, 13, 18, 1920, 3]}, "items": [{"id": "p_2822", "content": "Death, Sudden [SEP] The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiov", "score": 1, "type": null, "tokenized_content": [2, 3539, 16, 12446, 3, 1920, 20135, 10975, 1927, 2136, 8970, 23792, 4088, 16, 16687, 2007, 1920, 11047, 3257, 1927, 2698, 6329, 16, 5481, 16, 1930, 21129, 1020, 3]}]}
{"query": {"id": "q_2823", "content": "IVMP [SEP] dden death after a high dose of intravenous methylprednisolone (IVMP). These mechanisms are not well understood because, in most cas", "tokenized_content": [2, 4370, 6588, 3, 6758, 1917, 3539, 2256, 43, 2149, 3253, 1927, 7307, 30087, 12, 4370, 6588, 13, 18, 2144, 3531, 2032, 2084, 2486, 7372, 2882, 16, 1922, 2501, 4373, 3]}, "items": [{"id": "p_2823", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_2824", "content": "azidothymidine [SEP] Lifetime treatment of mice with azidothymidine (AZT) produces myelodysplasia.", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 9416, 2311, 1927, 2518, 1956, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 9300, 5707, 26812, 9352, 18, 3]}, "items": [{"id": "p_2824", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_2825", "content": "AZT [SEP] Lifetime treatment of mice with azidothymidine (AZT) produces myelodysplasia.", "tokenized_content": [2, 28301, 3, 9416, 2311, 1927, 2518, 1956, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 9300, 5707, 26812, 9352, 18, 3]}, "items": [{"id": "p_2825", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_2826", "content": "myelodysplasia [SEP] Lifetime treatment of mice with azidothymidine (AZT) produces myelodysplasia.", "tokenized_content": [2, 5707, 26812, 9352, 3, 9416, 2311, 1927, 2518, 1956, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 9300, 5707, 26812, 9352, 18, 3]}, "items": [{"id": "p_2826", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_2827", "content": "AZT [SEP] AZT has induced a macrocytic anemia in AIDS patients on long term A", "tokenized_content": [2, 28301, 3, 28301, 2258, 2719, 43, 21924, 4274, 10679, 1922, 8494, 2132, 1990, 2815, 2576, 43, 3]}, "items": [{"id": "p_2827", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_2828", "content": "macrocytic anemia [SEP] AZT has induced a macrocytic anemia in AIDS patients on long term AZT therapy. It is generally assu", "tokenized_content": [2, 21924, 4274, 10679, 3, 28301, 2258, 2719, 43, 21924, 4274, 10679, 1922, 8494, 2132, 1990, 2815, 2576, 28301, 3181, 18, 2176, 1977, 4933, 2088, 1032, 3]}, "items": [{"id": "p_2828", "content": "Anemia, Macrocytic [SEP] Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21924, 4274, 3, 10679, 4378, 2007, 4327, 2254, 2791, 14161, 16, 2502, 2667, 13776, 18021, 5148, 1005, 3776, 12, 29635, 13, 1930, 2502, 2667, 13776, 18021, 5148, 1005, 3]}]}
{"query": {"id": "q_2829", "content": "AIDS [SEP] AZT has induced a macrocytic anemia in AIDS patients on long term AZT therapy. It is generally assumed that", "tokenized_content": [2, 8494, 3, 28301, 2258, 2719, 43, 21924, 4274, 10679, 1922, 8494, 2132, 1990, 2815, 2576, 28301, 3181, 18, 2176, 1977, 4933, 7696, 1988, 3]}, "items": [{"id": "p_2829", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_2830", "content": "thymidine [SEP] n is stopped by the insertion of AZT into the chain in place of thymidine thus preventing the phosphate hydroxyl linkages and therefore s", "tokenized_content": [2, 16253, 3, 56, 1977, 12032, 2007, 1920, 7413, 1927, 28301, 2460, 1920, 4659, 1922, 4368, 1927, 16253, 2842, 8444, 1920, 5413, 9420, 19949, 1930, 2955, 61, 3]}, "items": [{"id": "p_2830", "content": "Thymidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16253, 3, 3]}]}
{"query": {"id": "q_2831", "content": "phosphate [SEP] of AZT into the chain in place of thymidine thus preventing the phosphate hydroxyl linkages and therefore suppresses hemopoietic progenit", "tokenized_content": [2, 5413, 3, 1927, 28301, 2460, 1920, 4659, 1922, 4368, 1927, 16253, 2842, 8444, 1920, 5413, 9420, 19949, 1930, 2955, 12987, 3243, 9251, 6502, 1932, 3]}, "items": [{"id": "p_2831", "content": "Phosphates [SEP] Inorganic salts of phosphoric acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26473, 3, 13849, 16028, 1927, 3421, 1935, 2687, 18, 3]}]}
{"query": {"id": "q_2832", "content": "thrombocytopenia [SEP] 2.5 x 10(6). Histological examination on 9 of 10 mice with such thrombocytopenia showed changes compatible with myelodysplastic syndrome (MDS). ", "tokenized_content": [2, 17100, 3, 22, 18, 25, 66, 2119, 12, 26, 13, 18, 6791, 4981, 1990, 29, 1927, 2119, 2518, 1956, 2427, 17100, 2594, 2840, 11290, 1956, 5707, 26812, 14170, 4741, 12, 3]}, "items": [{"id": "p_2832", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_2833", "content": "myelodysplastic syndrome [SEP]  mice with such thrombocytopenia showed changes compatible with myelodysplastic syndrome (MDS). A variety of histological patterns was observed. There w", "tokenized_content": [2, 5707, 26812, 14170, 4741, 3, 2518, 1956, 2427, 17100, 2594, 2840, 11290, 1956, 5707, 26812, 14170, 4741, 12, 10697, 13, 18, 43, 5386, 1927, 6791, 4147, 1982, 2528, 18, 2276, 3]}, "items": [{"id": "p_2833", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_2834", "content": "MDS [SEP] openia showed changes compatible with myelodysplastic syndrome (MDS). A variety of histological patterns was observed. There were t", "tokenized_content": [2, 10697, 3, 4437, 2126, 2594, 2840, 11290, 1956, 5707, 26812, 14170, 4741, 12, 10697, 13, 18, 43, 5386, 1927, 6791, 4147, 1982, 2528, 18, 2276, 1985, 62, 3]}, "items": [{"id": "p_2834", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_2835", "content": "myelodysplasia [SEP] cal patterns was observed. There were two cases of hypocellular myelodysplasia, two cases of hypersegmented myelodysplastic granulocytosis, tw", "tokenized_content": [2, 5707, 26812, 9352, 3, 2570, 4147, 1982, 2528, 18, 2276, 1985, 2288, 2919, 1927, 20956, 3386, 5707, 26812, 9352, 16, 2288, 2919, 1927, 10694, 6541, 9426, 5707, 26812, 14170, 9015, 3]}, "items": [{"id": "p_2835", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_2836", "content": "myelodysplastic [SEP]  mice with such thrombocytopenia showed changes compatible with myelodysplastic syndrome (MDS). A variety of histological patterns was observed", "tokenized_content": [2, 5707, 26812, 14170, 3, 2518, 1956, 2427, 17100, 2594, 2840, 11290, 1956, 5707, 26812, 14170, 4741, 12, 10697, 13, 18, 43, 5386, 1927, 6791, 4147, 1982, 2528, 3]}, "items": [{"id": "p_2836", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_2837", "content": "hyperplastic marrow [SEP] e nuclei, one case of megakaryocytic myelosis associated with a hyperplastic marrow, dysmyelopoiesis and a hypocellular marrow and two cases of mye", "tokenized_content": [2, 28733, 6599, 3, 47, 6742, 16, 2340, 3087, 1927, 22695, 8316, 5707, 2475, 2458, 1956, 43, 28733, 6599, 16, 26906, 12592, 17228, 1930, 43, 20956, 3386, 6599, 1930, 2288, 2919, 3]}, "items": [{"id": "p_2837", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_2838", "content": "dysmyelopoiesis [SEP]  megakaryocytic myelosis associated with a hyperplastic marrow, dysmyelopoiesis and a hypocellular marrow and two cases of myelodysplasia with ", "tokenized_content": [2, 26906, 12592, 17228, 3, 22695, 8316, 5707, 2475, 2458, 1956, 43, 28733, 6599, 16, 26906, 12592, 17228, 1930, 43, 20956, 3386, 6599, 1930, 2288, 2919, 1927, 5707, 26812, 9352, 1956, 3]}, "items": [{"id": "p_2838", "content": "Myelodysplastic Syndromes [SEP] Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominant", "score": 1, "type": null, "tokenized_content": [2, 5707, 26812, 14170, 12688, 3, 11597, 9960, 4402, 2024, 4414, 4378, 2007, 14095, 1922, 2340, 2014, 2253, 9960, 2024, 10439, 18, 2611, 6136, 3]}]}
{"query": {"id": "q_2839", "content": "hypocellular marrow [SEP] is associated with a hyperplastic marrow, dysmyelopoiesis and a hypocellular marrow and two cases of myelodysplasia with dyserythropoiesis, hemosid", "tokenized_content": [2, 20956, 3386, 6599, 3, 1977, 2458, 1956, 43, 28733, 6599, 16, 26906, 12592, 17228, 1930, 43, 20956, 3386, 6599, 1930, 2288, 2919, 1927, 5707, 26812, 9352, 1956, 3890, 24732, 17351, 3]}, "items": [{"id": "p_2839", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_2840", "content": "hemosiderosis [SEP]  marrow and two cases of myelodysplasia with dyserythropoiesis, hemosiderosis and a hypocellular marrow. Above mentioned AZT incorporation ma", "tokenized_content": [2, 3243, 8028, 4870, 3, 6599, 1930, 2288, 2919, 1927, 5707, 26812, 9352, 1956, 3890, 24732, 17351, 14780, 16, 3243, 8028, 4870, 1930, 43, 20956, 3386, 6599, 18, 3538, 6996, 28301, 3]}, "items": [{"id": "p_2840", "content": "Hemosiderosis [SEP] Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEA", "score": 1, "type": null, "tokenized_content": [2, 3243, 8028, 4870, 3, 2961, 1922, 2154, 2276, 1977, 43, 9612, 2760, 1922, 1920, 5680, 14846, 1927, 3362, 3878, 16, 4443, 1927, 3568, 1930, 1920, 29932, 1019, 3]}]}
{"query": {"id": "q_2841", "content": "NAD [SEP] Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice.", "tokenized_content": [2, 6577, 3, 4039, 1927, 3986, 3294, 1927, 6577, 17, 10416, 1990, 23311, 24126, 1922, 2518, 18, 3]}, "items": [{"id": "p_2841", "content": "NAD [SEP] A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is foun", "score": 1, "type": null, "tokenized_content": [2, 6577, 3, 43, 22051, 7179, 1927, 29117, 2199, 19730, 28735, 5482, 25, 11, 17, 23266, 6416, 1942, 10125, 25, 11, 17, 5413, 2007, 24937, 8611, 18, 2176, 1977, 5917, 1983, 3]}]}
{"query": {"id": "q_2842", "content": "acetaminophen [SEP] Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice.", "tokenized_content": [2, 23311, 3, 4039, 1927, 3986, 3294, 1927, 6577, 17, 10416, 1990, 23311, 24126, 1922, 2518, 18, 3]}, "items": [{"id": "p_2842", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2843", "content": "hepatotoxicity [SEP] Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice.", "tokenized_content": [2, 24126, 3, 4039, 1927, 3986, 3294, 1927, 6577, 17, 10416, 1990, 23311, 24126, 1922, 2518, 18, 3]}, "items": [{"id": "p_2843", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2844", "content": "nicotinic acid amide [SEP] Recently, we demonstrated the hepatoprotective effects of nicotinic acid amide, a selective inhibitor of poly(ADP-ribose) polymerase (PARP; EC", "tokenized_content": [2, 20239, 2687, 13601, 3, 3998, 16, 2038, 3161, 1920, 5746, 15305, 2564, 1927, 20239, 2687, 13601, 16, 43, 5328, 4106, 1927, 4286, 12, 9828, 17, 17870, 13, 6479, 12, 12007, 3]}, "items": [{"id": "p_2844", "content": "Niacinamide [SEP] An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure ", "score": 1, "type": null, "tokenized_content": [2, 21946, 3665, 5482, 3, 1925, 2715, 3547, 7295, 1966, 43, 4594, 1927, 1920, 22051, 6577, 18, 2496, 3065, 4550, 1977, 1922, 1920, 5455, 1930, 19, 2014, 12338, 3]}]}
{"query": {"id": "q_2845", "content": "poly(ADP-ribose) [SEP] ctive effects of nicotinic acid amide, a selective inhibitor of poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) on mice suffering from acetamino", "tokenized_content": [2, 4286, 12, 9828, 17, 17870, 13, 3, 3369, 2320, 2564, 1927, 20239, 2687, 13601, 16, 43, 5328, 4106, 1927, 4286, 12, 9828, 17, 17870, 13, 6479, 12, 12007, 31, 3270, 3]}, "items": [{"id": "p_2845", "content": "Poly Adenosine Diphosphate Ribose [SEP] A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.\n ", "score": 1, "type": null, "tokenized_content": [2, 4286, 10125, 23266, 17870, 3, 43, 15176, 15274, 5333, 2037, 1920, 9828, 17, 17870, 11804, 1927, 21393, 17, 15643, 21302, 12, 6577, 13, 2007, 4286, 12, 9828, 17, 17870, 13, 20910, 18, 3]}]}
{"query": {"id": "q_2846", "content": "acetaminophen [SEP] P-ribose) polymerase (PARP; EC 2.4.2.30) on mice suffering from acetaminophen (AAP)-hepatitis, suggesting that the AAP-induced liver injury i", "tokenized_content": [2, 23311, 3, 58, 17, 17870, 13, 6479, 12, 12007, 31, 3270, 22, 18, 24, 18, 22, 18, 2627, 13, 1990, 2518, 11364, 2037, 23311, 12, 24349, 13, 17, 7977, 16, 3]}, "items": [{"id": "p_2846", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2847", "content": "AAP [SEP] erase (PARP; EC 2.4.2.30) on mice suffering from acetaminophen (AAP)-hepatitis, suggesting that the AAP-induced liver injury involv", "tokenized_content": [2, 24349, 3, 14821, 4127, 12, 12007, 31, 3270, 22, 18, 24, 18, 22, 18, 2627, 13, 1990, 2518, 11364, 2037, 23311, 12, 24349, 13, 17, 7977, 16, 3783, 1988, 1920, 3]}, "items": [{"id": "p_2847", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2848", "content": "hepatitis [SEP]  (PARP; EC 2.4.2.30) on mice suffering from acetaminophen (AAP)-hepatitis, suggesting that the AAP-induced liver injury involves a step w", "tokenized_content": [2, 7977, 3, 12, 12007, 31, 3270, 22, 18, 24, 18, 22, 18, 2627, 13, 1990, 2518, 11364, 2037, 23311, 12, 24349, 13, 17, 7977, 16, 3783, 1988, 1920, 24349, 17, 3]}, "items": [{"id": "p_2848", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2849", "content": "liver injury [SEP]  acetaminophen (AAP)-hepatitis, suggesting that the AAP-induced liver injury involves a step which depends on adenoribosylation. The present", "tokenized_content": [2, 3568, 4047, 3, 23311, 12, 24349, 13, 17, 7977, 16, 3783, 1988, 1920, 24349, 17, 2719, 3568, 4047, 7077, 43, 3537, 2154, 7315, 1990, 29639, 3027, 29258, 3017, 18, 1920, 3]}, "items": [{"id": "p_2849", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2850", "content": "NAD [SEP]  study investigates the effects of a diet free of precursors of NAD, the substrate on which PARP acts, in female NMRI mice with AAP", "tokenized_content": [2, 6577, 3, 2161, 24609, 1920, 2564, 1927, 43, 3986, 3294, 1927, 10416, 1927, 6577, 16, 1920, 4510, 1990, 2154, 12007, 8016, 16, 1922, 4232, 5923, 1033, 2518, 1956, 24349, 3]}, "items": [{"id": "p_2850", "content": "NAD [SEP] A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is foun", "score": 1, "type": null, "tokenized_content": [2, 6577, 3, 43, 22051, 7179, 1927, 29117, 2199, 19730, 28735, 5482, 25, 11, 17, 23266, 6416, 1942, 10125, 25, 11, 17, 5413, 2007, 24937, 8611, 18, 2176, 1977, 5917, 1983, 3]}]}
{"query": {"id": "q_2851", "content": "ethanol [SEP]  with AAP hepatitis and evaluates the influence of simultaneous ethanol consumption in these animals. Liver injuries were quantified as", "tokenized_content": [2, 5757, 3, 1956, 24349, 7977, 1930, 22494, 1920, 4039, 1927, 5710, 5757, 5434, 1922, 2144, 3555, 18, 3568, 8209, 1985, 6395, 1966, 3]}, "items": [{"id": "p_2851", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_2852", "content": "Liver injuries [SEP] influence of simultaneous ethanol consumption in these animals. Liver injuries were quantified as serum activities of glutamate-oxaloacetate t", "tokenized_content": [2, 3568, 8209, 3, 4039, 1927, 5710, 5757, 5434, 1922, 2144, 3555, 18, 3568, 8209, 1985, 6395, 1966, 3256, 4209, 1927, 7627, 17, 18512, 15365, 9215, 2057, 62, 3]}, "items": [{"id": "p_2852", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2853", "content": "glutamate [SEP]  animals. Liver injuries were quantified as serum activities of glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transami", "tokenized_content": [2, 7627, 3, 3555, 18, 3568, 8209, 1985, 6395, 1966, 3256, 4209, 1927, 7627, 17, 18512, 15365, 9215, 2057, 24376, 12, 14643, 13, 1930, 7627, 17, 11867, 2127, 14981, 3]}, "items": [{"id": "p_2853", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_2854", "content": "oxaloacetate [SEP] Liver injuries were quantified as serum activities of glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT). W", "tokenized_content": [2, 18512, 15365, 9215, 2057, 3, 3568, 8209, 1985, 6395, 1966, 3256, 4209, 1927, 7627, 17, 18512, 15365, 9215, 2057, 24376, 12, 14643, 13, 1930, 7627, 17, 11867, 24376, 12, 4882, 3]}, "items": [{"id": "p_2854", "content": "Oxaloacetic Acid [SEP] A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC", "score": 1, "type": null, "tokenized_content": [2, 18512, 21117, 2687, 3, 43, 9192, 26431, 2687, 21876, 1988, 1977, 1925, 2715, 4487, 6129, 1927, 1920, 23782, 2687, 4048, 18, 2176, 2112, 1998, 9076, 1942, 23047, 3]}]}
{"query": {"id": "q_2855", "content": "pyruvate [SEP] ties of glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT). While AAP caused a 117-fold elevation of se", "tokenized_content": [2, 11867, 3, 25439, 1927, 7627, 17, 18512, 15365, 9215, 2057, 24376, 12, 14643, 13, 1930, 7627, 17, 11867, 24376, 12, 4882, 1031, 13, 18, 2679, 24349, 4189, 43, 11678, 17, 3]}, "items": [{"id": "p_2855", "content": "Pyruvic Acid [SEP] An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retard", "score": 1, "type": null, "tokenized_content": [2, 6487, 12631, 1935, 2687, 3, 1925, 6129, 3547, 1922, 1920, 4714, 1927, 16282, 16, 2697, 16, 1930, 27751, 18, 1922, 26901, 6179, 16, 2496, 6638, 1977, 14428, 3]}]}
{"query": {"id": "q_2856", "content": "NAA [SEP] y exacerbated by ethanol and inhibited by nicotinic acid amide (NAA), adverse effects were noted in animals fed a diet free of prec", "tokenized_content": [2, 22509, 3, 67, 19159, 2007, 5757, 1930, 5069, 2007, 20239, 2687, 13601, 12, 22509, 13, 16, 5246, 2564, 1985, 5040, 1922, 3555, 5788, 43, 3986, 3294, 1927, 3648, 3]}, "items": [{"id": "p_2856", "content": "Niacinamide [SEP] An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure ", "score": 1, "type": null, "tokenized_content": [2, 21946, 3665, 5482, 3, 1925, 2715, 3547, 7295, 1966, 43, 4594, 1927, 1920, 22051, 6577, 18, 2496, 3065, 4550, 1977, 1922, 1920, 5455, 1930, 19, 2014, 12338, 3]}]}
{"query": {"id": "q_2857", "content": "liver damage [SEP]  exacerbation caused by ethanol in mice on a standard diet, the liver damage was inhibited by 50% by ethanol. A further 64% reduction of hep", "tokenized_content": [2, 3568, 4293, 3, 17021, 4189, 2007, 5757, 1922, 2518, 1990, 43, 2970, 3986, 16, 1920, 3568, 4293, 1982, 5069, 2007, 2761, 9, 2007, 5757, 18, 43, 2520, 4723, 9, 3378, 3]}, "items": [{"id": "p_2857", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2858", "content": "hepatic damage [SEP]  pharmaceutical preparations of acetaminophen in order to avoid hepatic damage in patients treated with this widely used analgesic.", "tokenized_content": [2, 6095, 4293, 3, 11106, 9815, 1927, 23311, 1922, 3238, 1942, 5161, 6095, 4293, 1922, 2132, 2868, 1956, 2052, 5673, 2251, 14501, 18, 3]}, "items": [{"id": "p_2858", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2859", "content": "cibenzoline [SEP] Antiarrhythmic plasma concentrations of cibenzoline on canine ventricular arrhythmias.", "tokenized_content": [2, 29435, 4389, 8419, 3, 2246, 23246, 4913, 3582, 3295, 1927, 29435, 4389, 8419, 1990, 13617, 6493, 16934, 18, 3]}, "items": [{"id": "p_2859", "content": "cifenline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3371, 14946, 3701, 3, 3]}]}
{"query": {"id": "q_2860", "content": "ventricular arrhythmias [SEP] Antiarrhythmic plasma concentrations of cibenzoline on canine ventricular arrhythmias.", "tokenized_content": [2, 6493, 16934, 3, 2246, 23246, 4913, 3582, 3295, 1927, 29435, 4389, 8419, 1990, 13617, 6493, 16934, 18, 3]}, "items": [{"id": "p_2860", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2861", "content": "digitalis [SEP] Using two-stage coronary ligation-, digitalis-, and adrenaline-induced canine ventricular arrhythmias, antiar", "tokenized_content": [2, 8225, 1937, 3, 2193, 2288, 17, 3587, 5846, 11102, 17, 16, 8225, 1937, 17, 16, 1930, 10651, 2053, 17, 2719, 13617, 6493, 16934, 16, 2246, 1933, 3]}, "items": [{"id": "p_2861", "content": "Digitalis Glycosides [SEP] Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also", "score": 1, "type": null, "tokenized_content": [2, 8225, 1937, 28170, 3, 28170, 2037, 4793, 1927, 1920, 9487, 8225, 1937, 18, 2673, 1927, 2144, 2032, 4707, 1966, 21129, 24970, 1930, 2246, 17, 18346, 4820, 18, 3063, 2222, 3]}]}
{"query": {"id": "q_2862", "content": "adrenaline [SEP] Using two-stage coronary ligation-, digitalis-, and adrenaline-induced canine ventricular arrhythmias, antiarrhythmic effects ", "tokenized_content": [2, 10651, 2053, 3, 2193, 2288, 17, 3587, 5846, 11102, 17, 16, 8225, 1937, 17, 16, 1930, 10651, 2053, 17, 2719, 13617, 6493, 16934, 16, 2246, 23246, 4913, 2564, 3]}, "items": [{"id": "p_2862", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_2863", "content": "ventricular arrhythmias [SEP] e coronary ligation-, digitalis-, and adrenaline-induced canine ventricular arrhythmias, antiarrhythmic effects of cibenzoline were examined and the mi", "tokenized_content": [2, 6493, 16934, 3, 47, 5846, 11102, 17, 16, 8225, 1937, 17, 16, 1930, 10651, 2053, 17, 2719, 13617, 6493, 16934, 16, 2246, 23246, 4913, 2564, 1927, 29435, 4389, 8419, 1985, 3]}, "items": [{"id": "p_2863", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2864", "content": "cibenzoline [SEP] duced canine ventricular arrhythmias, antiarrhythmic effects of cibenzoline were examined and the minimum effective plasma concentration fo", "tokenized_content": [2, 29435, 4389, 8419, 3, 10677, 1919, 13617, 6493, 16934, 16, 2246, 23246, 4913, 2564, 1927, 29435, 4389, 8419, 1985, 3572, 1930, 1920, 6081, 3655, 3582, 3110, 5917, 3]}, "items": [{"id": "p_2864", "content": "cifenline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3371, 14946, 3701, 3, 3]}]}
{"query": {"id": "q_2865", "content": "arrhythmia [SEP] igation-, digitalis-, and adrenaline-induced canine ventricular arrhythmias, antiarrhythmic effects of cibenzoline were examined and the m", "tokenized_content": [2, 18346, 3, 12114, 1929, 17, 16, 8225, 1937, 17, 16, 1930, 10651, 2053, 17, 2719, 13617, 6493, 16934, 16, 2246, 23246, 4913, 2564, 1927, 29435, 4389, 8419, 1985, 3572, 1930, 3]}, "items": [{"id": "p_2865", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2866", "content": "Cibenzoline [SEP]  plasma concentration for each arrhythmia model was determined. Cibenzoline suppressed all the arrhythmias, and the minimum effective plasm", "tokenized_content": [2, 29435, 4389, 8419, 3, 3582, 3110, 1958, 2362, 18346, 2322, 1982, 3180, 18, 29435, 4389, 8419, 7657, 2136, 1920, 16934, 16, 1930, 1920, 6081, 3655, 3018, 3]}, "items": [{"id": "p_2866", "content": "cifenline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3371, 14946, 3701, 3, 3]}]}
{"query": {"id": "q_2867", "content": "arrhythmias [SEP] igation-, digitalis-, and adrenaline-induced canine ventricular arrhythmias, antiarrhythmic effects of cibenzoline were examined and the mi", "tokenized_content": [2, 16934, 3, 12114, 1929, 17, 16, 8225, 1937, 17, 16, 1930, 10651, 2053, 17, 2719, 13617, 6493, 16934, 16, 2246, 23246, 4913, 2564, 1927, 29435, 4389, 8419, 1985, 3572, 1930, 3]}, "items": [{"id": "p_2867", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2868", "content": "mexiletine [SEP] rrhythmias. This pharmacological profile is similar to those of mexiletine and tocainide, and all three drugs have central nervous system ", "tokenized_content": [2, 10114, 2383, 4425, 3, 5162, 10245, 15519, 18, 2052, 7683, 5174, 1977, 2551, 1942, 2690, 1927, 10114, 2383, 4425, 1930, 21682, 2005, 2261, 16, 1930, 2136, 2559, 4195, 2162, 4101, 3]}, "items": [{"id": "p_2868", "content": "Mexiletine [SEP] Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10114, 2383, 4425, 3, 2246, 23246, 4913, 5899, 24645, 2551, 1942, 19567, 18, 2176, 2278, 2162, 2673, 26572, 2031, 3879, 18, 3]}]}
{"query": {"id": "q_2869", "content": "tocainide [SEP] s pharmacological profile is similar to those of mexiletine and tocainide, and all three drugs have central nervous system (CNS) stimulan", "tokenized_content": [2, 21682, 2005, 2261, 3, 61, 7683, 5174, 1977, 2551, 1942, 2690, 1927, 10114, 2383, 4425, 1930, 21682, 2005, 2261, 16, 1930, 2136, 2559, 4195, 2162, 4101, 7580, 2433, 12, 7520, 3]}, "items": [{"id": "p_2869", "content": "Tocainide [SEP] An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21682, 2005, 2261, 3, 1925, 2246, 23246, 4913, 5899, 2154, 14235, 43, 2889, 17, 1930, 3528, 17, 3100, 3367, 1927, 5227, 5628, 18, 3]}]}
{"query": {"id": "q_2870", "content": "hypotensive [SEP] ystem (CNS) stimulant action. Because cibenzoline had only weak hypotensive and sinus node depressive effects and was found to be orally ac", "tokenized_content": [2, 12201, 3766, 3, 24018, 2057, 1035, 12, 7520, 13, 24252, 4615, 18, 2882, 29435, 4389, 8419, 2430, 2444, 5015, 12201, 3766, 1930, 9414, 6267, 7745, 2564, 1930, 1982, 2435, 1942, 3]}, "items": [{"id": "p_2870", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2871", "content": "depressive [SEP] n. Because cibenzoline had only weak hypotensive and sinus node depressive effects and was found to be orally active when given to coronar", "tokenized_content": [2, 7745, 3, 56, 18, 2882, 29435, 4389, 8419, 2430, 2444, 5015, 12201, 3766, 1930, 9414, 6267, 7745, 2564, 1930, 1982, 2435, 1942, 1998, 12950, 3500, 2469, 3258, 1942, 5548, 1933, 3]}, "items": [{"id": "p_2871", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2872", "content": "penicillamine [SEP] Immunopathology of penicillamine-induced glomerular disease.", "tokenized_content": [2, 25142, 3812, 3, 6595, 9112, 2591, 1927, 25142, 3812, 17, 2719, 11655, 2573, 18, 3]}, "items": [{"id": "p_2872", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_2873", "content": "glomerular disease [SEP] Immunopathology of penicillamine-induced glomerular disease.", "tokenized_content": [2, 11655, 2573, 3, 6595, 9112, 2591, 1927, 25142, 3812, 17, 2719, 11655, 2573, 18, 3]}, "items": [{"id": "p_2873", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2874", "content": "rheumatoid arthritis [SEP] Four patients with rheumatoid arthritis developed heavy proteinuria after five to 12 months of treatmen", "tokenized_content": [2, 13053, 8884, 3, 3006, 2132, 1956, 13053, 8884, 3530, 7881, 15831, 2256, 3628, 1942, 2369, 3221, 1927, 2297, 19047, 3]}, "items": [{"id": "p_2874", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_2875", "content": "proteinuria [SEP] Four patients with rheumatoid arthritis developed heavy proteinuria after five to 12 months of treatment with D-penicillamine. Ligh", "tokenized_content": [2, 15831, 3, 3006, 2132, 1956, 13053, 8884, 3530, 7881, 15831, 2256, 3628, 1942, 2369, 3221, 1927, 2311, 1956, 46, 17, 25142, 3812, 18, 3650, 1023, 3]}, "items": [{"id": "p_2875", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2876", "content": "D-penicillamine [SEP] ped heavy proteinuria after five to 12 months of treatment with D-penicillamine. Light microscopy of renal biopsy samples showed minimal glomer", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 5296, 7881, 15831, 2256, 3628, 1942, 2369, 3221, 1927, 2311, 1956, 46, 17, 25142, 3812, 18, 3696, 5441, 1927, 4604, 6831, 2785, 2594, 6343, 8778, 3]}, "items": [{"id": "p_2876", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_2877", "content": "membranous glomerulonephritis [SEP] sits of IgG and C3. The findings were similar to those in early membranous glomerulonephritis, differences being observed however in the results of staining ", "tokenized_content": [2, 22890, 27057, 3, 14949, 1036, 1927, 5166, 1930, 8351, 18, 1920, 3056, 1985, 2551, 1942, 2690, 1922, 3120, 22890, 27057, 16, 2886, 3301, 2528, 2406, 1922, 1920, 2274, 1927, 4166, 3]}, "items": [{"id": "p_2877", "content": "Glomerulonephritis, Membranous [SEP] A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) o", "score": 1, "type": null, "tokenized_content": [2, 27057, 16, 22890, 3, 43, 2601, 1927, 27057, 1988, 1977, 4378, 2007, 1920, 4858, 1927, 3743, 14371, 12, 5508, 3260, 8926, 2796, 13, 57, 3]}]}
{"query": {"id": "q_2878", "content": "Ventricular fibrillation [SEP] Ventricular fibrillation from diatrizoate with and without chelating agents.", "tokenized_content": [2, 6493, 13671, 3, 6493, 13671, 2037, 24149, 3027, 13642, 2010, 1956, 1930, 2979, 25814, 4820, 18, 3]}, "items": [{"id": "p_2878", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_2879", "content": "diatrizoate [SEP] Ventricular fibrillation from diatrizoate with and without chelating agents.", "tokenized_content": [2, 24149, 3027, 13642, 2010, 3, 6493, 13671, 2037, 24149, 3027, 13642, 2010, 1956, 1930, 2979, 25814, 4820, 18, 3]}, "items": [{"id": "p_2879", "content": "Diatrizoate [SEP] A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studi", "score": 1, "type": null, "tokenized_content": [2, 24149, 3027, 13642, 2010, 3, 43, 5384, 2251, 66, 17, 6451, 3320, 3649, 18, 1966, 24149, 3027, 13642, 2010, 11443, 5277, 25157, 1930, 1966, 24149, 3027, 13642, 2010, 5227, 16, 2176, 1977, 2251, 1958, 8375, 2060, 1033, 3]}]}
{"query": {"id": "q_2880", "content": "toxicity [SEP] The toxicity of Renografin 76% was compared with that of Hypaque 76% by sele", "tokenized_content": [2, 5532, 3, 1920, 5532, 1927, 3866, 2685, 2624, 1921, 5439, 9, 1982, 2452, 1956, 1988, 1927, 2483, 15287, 2182, 5439, 9, 2007, 2484, 1021, 3]}, "items": [{"id": "p_2880", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2881", "content": "Renografin 76% [SEP] The toxicity of Renografin 76% was compared with that of Hypaque 76% by selective injection of", "tokenized_content": [2, 3866, 2685, 2624, 1921, 5439, 9, 3, 1920, 5532, 1927, 3866, 2685, 2624, 1921, 5439, 9, 1982, 2452, 1956, 1988, 1927, 2483, 15287, 2182, 5439, 9, 2007, 5328, 4107, 1927, 3]}, "items": [{"id": "p_2881", "content": "urovision [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14984, 7400, 2001, 3, 3]}]}
{"query": {"id": "q_2882", "content": "Hypaque 76% [SEP] The toxicity of Renografin 76% was compared with that of Hypaque 76% by selective injection of each into the right coronary artery o", "tokenized_content": [2, 2483, 15287, 2182, 5439, 9, 3, 1920, 5532, 1927, 3866, 2685, 2624, 1921, 5439, 9, 1982, 2452, 1956, 1988, 1927, 2483, 15287, 2182, 5439, 9, 2007, 5328, 4107, 1927, 2362, 3]}, "items": [{"id": "p_2882", "content": "urovision [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14984, 7400, 2001, 3, 3]}]}
{"query": {"id": "q_2883", "content": "Renografin [SEP] The toxicity of Renografin 76% was compared with that of Hypaque 76% by selective injectio", "tokenized_content": [2, 3866, 2685, 2624, 1921, 3, 1920, 5532, 1927, 3866, 2685, 2624, 1921, 5439, 9, 1982, 2452, 1956, 1988, 1927, 2483, 15287, 2182, 5439, 9, 2007, 5328, 27270, 3940, 3]}, "items": [{"id": "p_2883", "content": "Diatrizoate Meglumine [SEP] A versatile x-ray contrast medium for diagnostic radiology. It can be administered by most routes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24149, 3027, 13642, 2010, 11443, 5277, 25157, 3, 43, 20425, 66, 17, 6451, 3320, 3649, 1958, 4785, 19528, 18, 2176, 2112, 1998, 5254, 2007, 2501, 14057, 18, 3]}]}
{"query": {"id": "q_2884", "content": "sodium citrate [SEP] ronary artery of dogs. Renografin contains the chelating agents sodium citrate and disodium edetate, while Hypaque contains calcium disodium e", "tokenized_content": [2, 5227, 11599, 3, 25851, 2141, 5511, 1927, 7894, 18, 3866, 2685, 2624, 1921, 5461, 1920, 25814, 4820, 5227, 11599, 1930, 2054, 12757, 3347, 9215, 2057, 16, 2679, 2483, 15287, 2182, 3]}, "items": [{"id": "p_2884", "content": "sodium citrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5227, 11599, 3, 3]}]}
{"query": {"id": "q_2885", "content": "disodium edetate [SEP] gs. Renografin contains the chelating agents sodium citrate and disodium edetate, while Hypaque contains calcium disodium edetate and no sodium ", "tokenized_content": [2, 2054, 12757, 3347, 9215, 2057, 3, 5022, 18, 3866, 2685, 2624, 1921, 5461, 1920, 25814, 4820, 5227, 11599, 1930, 2054, 12757, 3347, 9215, 2057, 16, 2679, 2483, 15287, 2182, 5461, 3]}, "items": [{"id": "p_2885", "content": "Edetic Acid [SEP] A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing an", "score": 1, "type": null, "tokenized_content": [2, 3347, 3023, 2687, 3, 43, 25814, 5899, 1988, 23504, 1036, 43, 5386, 1927, 4286, 28144, 4905, 16525, 2427, 1966, 5016, 18, 2176, 1977, 2251, 1922, 11106, 16140, 1925, 3]}]}
{"query": {"id": "q_2886", "content": "Hypaque [SEP] The toxicity of Renografin 76% was compared with that of Hypaque 76% by selective injection of each into the right coronary arte", "tokenized_content": [2, 2483, 15287, 2182, 3, 1920, 5532, 1927, 3866, 2685, 2624, 1921, 5439, 9, 1982, 2452, 1956, 1988, 1927, 2483, 15287, 2182, 5439, 9, 2007, 5328, 4107, 1927, 2362, 2460, 1920, 3]}, "items": [{"id": "p_2886", "content": "Diatrizoate [SEP] A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studi", "score": 1, "type": null, "tokenized_content": [2, 24149, 3027, 13642, 2010, 3, 43, 5384, 2251, 66, 17, 6451, 3320, 3649, 18, 1966, 24149, 3027, 13642, 2010, 11443, 5277, 25157, 1930, 1966, 24149, 3027, 13642, 2010, 5227, 16, 2176, 1977, 2251, 1958, 8375, 2060, 1033, 3]}]}
{"query": {"id": "q_2887", "content": "calcium disodium edetate [SEP] nts sodium citrate and disodium edetate, while Hypaque contains calcium disodium edetate and no sodium citrate. Ventricular fibrillation occurred signif", "tokenized_content": [2, 5016, 2054, 12757, 3347, 9215, 2057, 3, 17969, 5227, 11599, 1930, 2054, 12757, 3347, 9215, 2057, 16, 2679, 2483, 15287, 2182, 5461, 5016, 2054, 12757, 3347, 9215, 2057, 1930, 2239, 3]}, "items": [{"id": "p_2887", "content": "Edetic Acid [SEP] A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing an", "score": 1, "type": null, "tokenized_content": [2, 3347, 3023, 2687, 3, 43, 25814, 5899, 1988, 23504, 1036, 43, 5386, 1927, 4286, 28144, 4905, 16525, 2427, 1966, 5016, 18, 2176, 1977, 2251, 1922, 11106, 16140, 1925, 3]}]}
{"query": {"id": "q_2888", "content": "Ventricular fibrillation [SEP] ypaque contains calcium disodium edetate and no sodium citrate. Ventricular fibrillation occurred significantly more often with Renografin, suggesting t", "tokenized_content": [2, 6493, 13671, 3, 21995, 15287, 2182, 5461, 5016, 2054, 12757, 3347, 9215, 2057, 1930, 2239, 5227, 11599, 18, 6493, 13671, 4807, 2567, 2253, 3868, 1956, 3866, 2685, 2624, 1921, 16, 3]}, "items": [{"id": "p_2888", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_2889", "content": "hemorrhage [SEP] Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral he", "tokenized_content": [2, 10489, 3, 4052, 12393, 1927, 18331, 7268, 10489, 3776, 1922, 43, 3321, 2322, 1927, 16170, 17, 2458, 24152, 2234, 3]}, "items": [{"id": "p_2889", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2890", "content": "warfarin [SEP] f anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage.", "tokenized_content": [2, 16170, 3, 48, 18331, 7268, 10489, 3776, 1922, 43, 3321, 2322, 1927, 16170, 17, 2458, 24152, 10489, 18, 3]}, "items": [{"id": "p_2890", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2891", "content": "intracerebral hemorrhage [SEP] duces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage.", "tokenized_content": [2, 24152, 10489, 3, 10677, 1918, 10489, 3776, 1922, 43, 3321, 2322, 1927, 16170, 17, 2458, 24152, 10489, 18, 3]}, "items": [{"id": "p_2891", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2892", "content": "Warfarin [SEP] Warfarin-associated intracerebral hemorrhage (W-ICH) is a severe type of", "tokenized_content": [2, 16170, 3, 16170, 17, 2458, 24152, 10489, 12, 65, 17, 14910, 13, 1977, 43, 4010, 2601, 1927, 3]}, "items": [{"id": "p_2892", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2893", "content": "intracerebral hemorrhage [SEP] Warfarin-associated intracerebral hemorrhage (W-ICH) is a severe type of stroke. There is no consensus on th", "tokenized_content": [2, 24152, 10489, 3, 16170, 17, 2458, 24152, 10489, 12, 65, 17, 14910, 13, 1977, 43, 4010, 2601, 1927, 5235, 18, 2276, 1977, 2239, 7076, 1990, 1913, 3]}, "items": [{"id": "p_2893", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2894", "content": "ICH [SEP] Warfarin-associated intracerebral hemorrhage (W-ICH) is a severe type of stroke. There is no consensus on the optim", "tokenized_content": [2, 14910, 3, 16170, 17, 2458, 24152, 10489, 12, 65, 17, 14910, 13, 1977, 43, 4010, 2601, 1927, 5235, 18, 2276, 1977, 2239, 7076, 1990, 1920, 3795, 3]}, "items": [{"id": "p_2894", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2895", "content": "stroke [SEP] associated intracerebral hemorrhage (W-ICH) is a severe type of stroke. There is no consensus on the optimal treatment for W-ICH. Usin", "tokenized_content": [2, 5235, 3, 2458, 24152, 10489, 12, 65, 17, 14910, 13, 1977, 43, 4010, 2601, 1927, 5235, 18, 2276, 1977, 2239, 7076, 1990, 1920, 5419, 2311, 1958, 65, 17, 14910, 18, 3]}, "items": [{"id": "p_2895", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_2896", "content": "prothrombin complex concentrate [SEP] ested whether the rapid reversal of anticoagulation using human prothrombin complex concentrate (PCC) can reduce hemorrhagic blood volume. Male CD-1 mice were ", "tokenized_content": [2, 23976, 2796, 18410, 3, 15879, 1007, 3053, 1920, 4052, 12393, 1927, 18331, 2193, 2616, 23976, 2796, 18410, 12, 16003, 13, 2112, 4412, 16052, 2877, 3776, 18, 4005, 2464, 17, 21, 3]}, "items": [{"id": "p_2896", "content": "prothrombin complex concentrates [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23976, 2796, 18410, 1036, 3, 3]}]}
{"query": {"id": "q_2897", "content": "PCC [SEP] of anticoagulation using human prothrombin complex concentrate (PCC) can reduce hemorrhagic blood volume. Male CD-1 mice were treat", "tokenized_content": [2, 16003, 3, 1927, 18331, 2193, 2616, 23976, 2796, 18410, 12, 16003, 13, 2112, 4412, 16052, 2877, 3776, 18, 4005, 2464, 17, 21, 2518, 1985, 2297, 3]}, "items": [{"id": "p_2897", "content": "prothrombin complex concentrates [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23976, 2796, 18410, 1036, 3, 3]}]}
{"query": {"id": "q_2898", "content": "warfarin [SEP] duce hemorrhagic blood volume. Male CD-1 mice were treated with warfarin (2 mg/kg over 24 h), resulting in a mean (+/-s.d.) Internationa", "tokenized_content": [2, 16170, 3, 10677, 1021, 16052, 2877, 3776, 18, 4005, 2464, 17, 21, 2518, 1985, 2868, 1956, 16170, 12, 22, 2786, 19, 3621, 2338, 2686, 50, 13, 16, 3864, 1922, 43, 3]}, "items": [{"id": "p_2898", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2899", "content": "hemorrhage [SEP] Warfarin-associated intracerebral hemorrhage (W-ICH) is a severe type of stroke. There is no consensus on th", "tokenized_content": [2, 10489, 3, 16170, 17, 2458, 24152, 10489, 12, 65, 17, 14910, 13, 1977, 43, 4010, 2601, 1927, 5235, 18, 2276, 1977, 2239, 7076, 1990, 1913, 3]}, "items": [{"id": "p_2899", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2900", "content": "hematomas [SEP]  P=0.015). In the saline group, 45% of the mice developed large hematomas (i.e., >15 microL). In contrast, such extensive lesions were ne", "tokenized_content": [2, 18984, 1036, 3, 58, 33, 20, 18, 16442, 13, 18, 1922, 1920, 5977, 2210, 16, 3607, 9, 1927, 1920, 2518, 3530, 3103, 18984, 1036, 12, 51, 18, 47, 18, 16, 3]}, "items": [{"id": "p_2900", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_2901", "content": "alcohol [SEP] Impact of alcohol exposure after pregnancy recognition on ultrasonographic fetal ", "tokenized_content": [2, 4284, 3, 3829, 1927, 4284, 3395, 2256, 5284, 5708, 1990, 12921, 4158, 5944, 3]}, "items": [{"id": "p_2901", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_2902", "content": "alcohol [SEP] er Jones and Smith (1973) reported on the devastation caused by alcohol exposure on fetal development, the rates of heavy drinking duri", "tokenized_content": [2, 4284, 3, 2668, 15938, 1930, 11742, 12, 19448, 13, 2568, 1990, 1920, 22265, 1943, 4189, 2007, 4284, 3395, 1990, 5944, 2740, 16, 1920, 3389, 1927, 7881, 7444, 2335, 1033, 3]}, "items": [{"id": "p_2902", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_2903", "content": "growth impairment [SEP] ned the utility of biometry for detecting alcohol-related fetal growth impairment. METHODS: We obtained fetal ultrasound measures from routine ul", "tokenized_content": [2, 2905, 6159, 3, 2069, 1007, 1920, 8531, 1927, 4071, 5414, 1958, 9227, 4284, 17, 2712, 5944, 2905, 6159, 18, 2860, 30, 2038, 2926, 5944, 7424, 3975, 2037, 7341, 3570, 3]}, "items": [{"id": "p_2903", "content": "Growth Disorders [SEP] Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportio", "score": 1, "type": null, "tokenized_content": [2, 2905, 4414, 3, 9804, 2037, 1920, 3361, 2851, 1958, 43, 2487, 2632, 1930, 3486, 1922, 2967, 2014, 2136, 1927, 1920, 2894, 30, 6178, 16, 3388, 16, 7345, 3976, 1914, 1037, 3]}]}
{"query": {"id": "q_2904", "content": "drug abuse [SEP]  groups after controlling for influences of gestational age and drug abuse. RESULTS: Nearly half of the pregnant drinkers abstained after ", "tokenized_content": [2, 2838, 7764, 3, 2671, 2256, 7138, 1958, 8061, 1927, 10000, 2632, 1930, 2838, 7764, 18, 2274, 30, 6737, 4768, 1927, 1920, 7808, 18960, 2872, 2695, 2256, 3]}, "items": [{"id": "p_2904", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_2905", "content": "reduced cerebellar growth [SEP]  postpregnancy recognition among the heavy drinkers resulted in reduced cerebellar growth as well as decreased cranial to body growth in comparison with ", "tokenized_content": [2, 3028, 11459, 2905, 3, 18732, 6541, 24254, 13796, 5708, 2706, 1920, 7881, 18960, 4306, 1922, 3028, 11459, 2905, 1966, 2486, 1966, 3261, 13598, 1942, 3362, 2905, 1922, 3723, 1956, 3]}, "items": [{"id": "p_2905", "content": "Growth Disorders [SEP] Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportio", "score": 1, "type": null, "tokenized_content": [2, 2905, 4414, 3, 9804, 2037, 1920, 3361, 2851, 1958, 43, 2487, 2632, 1930, 3486, 1922, 2967, 2014, 2136, 1927, 1920, 2894, 30, 6178, 16, 3388, 16, 7345, 3976, 1914, 1037, 3]}]}
{"query": {"id": "q_2906", "content": "decreased cranial to body growth [SEP] heavy drinkers resulted in reduced cerebellar growth as well as decreased cranial to body growth in comparison with women who either quit drinking or who were n", "tokenized_content": [2, 3261, 13598, 1942, 3362, 2905, 3, 7881, 18960, 4306, 1922, 3028, 11459, 2905, 1966, 2486, 1966, 3261, 13598, 1942, 3362, 2905, 1922, 3723, 1956, 3089, 2746, 3108, 15334, 7444, 2014, 3]}, "items": [{"id": "p_2906", "content": "Growth Disorders [SEP] Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportio", "score": 1, "type": null, "tokenized_content": [2, 2905, 4414, 3, 9804, 2037, 1920, 3361, 2851, 1958, 43, 2487, 2632, 1930, 3486, 1922, 2967, 2014, 2136, 1927, 1920, 2894, 30, 6178, 16, 3388, 16, 7345, 3976, 1914, 1037, 3]}]}
{"query": {"id": "q_2907", "content": "Amphetamine [SEP] on with women who either quit drinking or who were nondrinkers. Amphetamine abuse was predictive of larger cranial to body growth ratios. C", "tokenized_content": [2, 19057, 3, 1990, 1956, 3089, 2746, 3108, 15334, 7444, 2014, 2746, 1985, 13125, 5572, 13548, 1036, 18, 19057, 7764, 1982, 6207, 1927, 4327, 13598, 1942, 3362, 2905, 5835, 18, 45, 3]}, "items": [{"id": "p_2907", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2908", "content": "overactive bladder [SEP] Urinary symptoms and quality of life changes in Thai women with overactive bladder after tolterodine treatment.", "tokenized_content": [2, 2338, 3849, 7821, 3, 7075, 3601, 1930, 3455, 1927, 3308, 2840, 1922, 26056, 3089, 1956, 2338, 3849, 7821, 2256, 21930, 1967, 26831, 2311, 18, 3]}, "items": [{"id": "p_2908", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_2909", "content": "tolterodine [SEP] ity of life changes in Thai women with overactive bladder after tolterodine treatment.", "tokenized_content": [2, 21930, 1967, 26831, 3, 2176, 1012, 1927, 3308, 2840, 1922, 26056, 3089, 1956, 2338, 3849, 7821, 2256, 21930, 1967, 26831, 2311, 18, 3]}, "items": [{"id": "p_2909", "content": "tolterodine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21930, 1967, 26831, 3, 3]}]}
{"query": {"id": "q_2910", "content": "overactive bladder [SEP] urinary symptoms and quality of life changes in Thai women with overactive bladder (OAB) after tolterodine treatment. MATERIAL AND METHOD: Thirty ", "tokenized_content": [2, 2338, 3849, 7821, 3, 7075, 3601, 1930, 3455, 1927, 3308, 2840, 1922, 26056, 3089, 1956, 2338, 3849, 7821, 12, 8965, 1014, 13, 2256, 21930, 1967, 26831, 2311, 18, 3485, 1930, 3]}, "items": [{"id": "p_2910", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_2911", "content": "OAB [SEP]  quality of life changes in Thai women with overactive bladder (OAB) after tolterodine treatment. MATERIAL AND METHOD: Thirty women", "tokenized_content": [2, 8965, 1014, 3, 3455, 1927, 3308, 2840, 1922, 26056, 3089, 1956, 2338, 3849, 7821, 12, 8965, 1014, 13, 2256, 21930, 1967, 26831, 2311, 18, 3485, 1930, 2417, 30, 9942, 3089, 3]}, "items": [{"id": "p_2911", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_2912", "content": "tolterodine [SEP]  life changes in Thai women with overactive bladder (OAB) after tolterodine treatment. MATERIAL AND METHOD: Thirty women (aged 30-77 years)", "tokenized_content": [2, 21930, 1967, 26831, 3, 3308, 2840, 1922, 26056, 3089, 1956, 2338, 3849, 7821, 12, 8965, 1014, 13, 2256, 21930, 1967, 26831, 2311, 18, 3485, 1930, 2417, 30, 9942, 3089, 12, 3]}, "items": [{"id": "p_2912", "content": "tolterodine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21930, 1967, 26831, 3, 3]}]}
{"query": {"id": "q_2913", "content": "Tolterodine [SEP]  from January to April 2004 were included in the present study. Tolterodine 2 mg, twice daily was given. After 8 weeks treatment, changes i", "tokenized_content": [2, 21930, 1967, 26831, 3, 2037, 8555, 1942, 11071, 4247, 1985, 3063, 1922, 1920, 2481, 2161, 18, 21930, 1967, 26831, 22, 2786, 16, 6470, 4692, 1982, 3258, 18, 2256, 28, 3625, 3]}, "items": [{"id": "p_2913", "content": "tolterodine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21930, 1967, 26831, 3, 3]}]}
{"query": {"id": "q_2914", "content": "nocturia [SEP] rom 16. 7 +/- 5. 3 to 6. 7 +/- 2.4 times per day. The number of nocturia episodes decreased from 5.4 +/- 4.2 to 1.1 +/- 1.0 times per ni", "tokenized_content": [2, 17055, 8754, 3, 15612, 2641, 18, 27, 15, 19, 17, 25, 18, 23, 1942, 26, 18, 27, 15, 19, 17, 22, 18, 24, 3586, 2079, 3007, 18, 1920, 2529, 1927, 3]}, "items": [{"id": "p_2914", "content": "Nocturia [SEP] Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladde", "score": 1, "type": null, "tokenized_content": [2, 17055, 8754, 3, 6439, 3674, 2636, 2019, 9609, 1988, 12151, 8299, 5006, 18, 2176, 1977, 3868, 2458, 1956, 17792, 10849, 16, 4032, 9695, 16, 2014, 18208, 10882, 1021, 3]}]}
{"query": {"id": "q_2915", "content": "dry month [SEP] to 1.1 +/- 1.0 times per night. The most common side effect was dry month in 5 cases (16.7%) with 2 cases reporting a moderate degree and", "tokenized_content": [2, 7143, 2935, 3, 1942, 21, 18, 21, 15, 19, 17, 21, 18, 20, 3586, 2079, 9609, 18, 1920, 2501, 3059, 4159, 2495, 1982, 7143, 2935, 1922, 25, 2919, 12, 2641, 3]}, "items": [{"id": "p_2915", "content": "Xerostomia [SEP] Decreased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27833, 28009, 2126, 3, 3261, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_2916", "content": "dry mouth [SEP] one case (3.3%) withdrew from the present study due to a severe dry mouth. The SF-36 scores changed significantly in the domains of physi", "tokenized_content": [2, 7143, 11701, 3, 2340, 3087, 12, 23, 18, 23, 9, 13, 1956, 3883, 2370, 2037, 1920, 2481, 2161, 2810, 1942, 43, 4010, 7143, 11701, 18, 1920, 6347, 17, 3480, 3888, 3]}, "items": [{"id": "p_2916", "content": "Xerostomia [SEP] Decreased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27833, 28009, 2126, 3, 3261, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_2917", "content": "cocaine [SEP] Absence of acute cerebral vasoconstriction after cocaine-associated subarachnoid hemorrhage.", "tokenized_content": [2, 9045, 3, 3905, 1927, 3939, 6329, 21843, 2256, 9045, 17, 2458, 23795, 10489, 18, 3]}, "items": [{"id": "p_2917", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2918", "content": "subarachnoid hemorrhage [SEP] nce of acute cerebral vasoconstriction after cocaine-associated subarachnoid hemorrhage.", "tokenized_content": [2, 23795, 10489, 3, 5301, 1021, 1927, 3939, 6329, 21843, 2256, 9045, 17, 2458, 23795, 10489, 18, 3]}, "items": [{"id": "p_2918", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_2919", "content": "Cocaine [SEP] INTRODUCTION: Cocaine use has been associated with neurovascular complications, inclu", "tokenized_content": [2, 9045, 3, 6935, 30, 9045, 2485, 2258, 2252, 2458, 1956, 26268, 5021, 16, 2296, 1032, 3]}, "items": [{"id": "p_2919", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2920", "content": "neurovascular complications [SEP] INTRODUCTION: Cocaine use has been associated with neurovascular complications, including arterial vasoconstriction and vasculitis. However, t", "tokenized_content": [2, 26268, 5021, 3, 6935, 30, 9045, 2485, 2258, 2252, 2458, 1956, 26268, 5021, 16, 2710, 6624, 21843, 1930, 21548, 18, 2406, 16, 62, 3]}, "items": [{"id": "p_2920", "content": "Thoracic Outlet Syndrome [SEP] A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the super", "score": 1, "type": null, "tokenized_content": [2, 10670, 21448, 4741, 3, 43, 26268, 4741, 2458, 1956, 10399, 1927, 1920, 19459, 17438, 31, 8959, 9188, 1928, 5511, 31, 1930, 8959, 9188, 1928, 7920, 2019, 1920, 3356, 3]}]}
{"query": {"id": "q_2921", "content": "vasculitis [SEP] vascular complications, including arterial vasoconstriction and vasculitis. However, there are few studies of angiographic effects of coca", "tokenized_content": [2, 21548, 3, 4541, 5021, 16, 2710, 6624, 21843, 1930, 21548, 18, 2406, 16, 2276, 2032, 3855, 2351, 1927, 22626, 2564, 1927, 6880, 1019, 3]}, "items": [{"id": "p_2921", "content": "Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.\n   ", "score": 1, "type": null, "tokenized_content": [2, 21548, 3, 4531, 1927, 2967, 2340, 1927, 1920, 2877, 7208, 16, 2710, 1920, 9345, 31, 14785, 31, 1930, 6172, 1927, 1920, 13040, 2433, 1922, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_2922", "content": "cocaine [SEP] itis. However, there are few studies of angiographic effects of cocaine on human cerebral arteries. Information on these effects could ", "tokenized_content": [2, 9045, 3, 2176, 1937, 18, 2406, 16, 2276, 2032, 3855, 2351, 1927, 22626, 2564, 1927, 9045, 1990, 2616, 6329, 9345, 18, 2988, 1990, 2144, 2564, 2578, 3]}, "items": [{"id": "p_2922", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2923", "content": "subarachnoid hemorrhage [SEP] be obtained from angiograms of patients with cocaine-associated subarachnoid hemorrhage (SAH) who underwent angiography shortly after cocaine use. METH", "tokenized_content": [2, 23795, 10489, 3, 1998, 2926, 2037, 29220, 28218, 1927, 2132, 1956, 9045, 17, 2458, 23795, 10489, 12, 11738, 13, 2746, 5468, 11676, 17002, 2256, 9045, 2485, 18, 2295, 3]}, "items": [{"id": "p_2923", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_2924", "content": "SAH [SEP] ms of patients with cocaine-associated subarachnoid hemorrhage (SAH) who underwent angiography shortly after cocaine use. METHODS: ", "tokenized_content": [2, 11738, 3, 3012, 1927, 2132, 1956, 9045, 17, 2458, 23795, 10489, 12, 11738, 13, 2746, 5468, 11676, 17002, 2256, 9045, 2485, 18, 2860, 30, 3]}, "items": [{"id": "p_2924", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_2925", "content": "aneurysmal [SEP] itis could be found in patients who underwent angiography after aneurysmal SAH associated with cocaine use.", "tokenized_content": [2, 13373, 1923, 3, 2176, 1937, 2578, 1998, 2435, 1922, 2132, 2746, 5468, 11676, 2256, 13373, 1923, 11738, 2458, 1956, 9045, 2485, 18, 3]}, "items": [{"id": "p_2925", "content": "Aneurysm, Ruptured [SEP] The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger ", "score": 1, "type": null, "tokenized_content": [2, 13373, 16, 24390, 3, 1920, 12650, 1941, 2014, 27823, 1927, 1920, 24214, 4821, 1927, 1920, 13373, 1923, 10791, 16, 5394, 3656, 12666, 1919, 2007, 12446, 15473, 3594, 18, 1920, 4733, 15378, 3]}]}
{"query": {"id": "q_2926", "content": "Atrial fibrillation [SEP] Atrial fibrillation following chemotherapy for stage IIIE diffuse large B-cell gast", "tokenized_content": [2, 9224, 13671, 3, 9224, 13671, 2894, 5318, 1958, 3587, 4337, 1021, 9435, 3103, 44, 17, 2024, 6215, 3]}, "items": [{"id": "p_2926", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2927", "content": "gastric lymphoma [SEP] tion following chemotherapy for stage IIIE diffuse large B-cell gastric lymphoma in a patient with myotonic dystrophy (Steinert's disease).", "tokenized_content": [2, 6319, 8636, 3, 8685, 1916, 2894, 5318, 1958, 3587, 4337, 1021, 9435, 3103, 44, 17, 2024, 6319, 8636, 1922, 43, 2774, 1956, 15924, 24970, 19321, 12, 21557, 3062, 11, 61, 3]}, "items": [{"id": "p_2927", "content": "Familial primary gastric lymphoma [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11444, 3065, 6319, 8636, 3, 3]}]}
{"query": {"id": "q_2928", "content": "myotonic dystrophy [SEP] ge IIIE diffuse large B-cell gastric lymphoma in a patient with myotonic dystrophy (Steinert's disease).", "tokenized_content": [2, 15924, 24970, 19321, 3, 3929, 4337, 1021, 9435, 3103, 44, 17, 2024, 6319, 8636, 1922, 43, 2774, 1956, 15924, 24970, 19321, 12, 21557, 3062, 11, 61, 2573, 13, 18, 3]}, "items": [{"id": "p_2928", "content": "Myotonic Dystrophy [SEP] Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLEC", "score": 1, "type": null, "tokenized_content": [2, 15924, 24970, 19321, 3, 15829, 4770, 4378, 2007, 7529, 12330, 10260, 31, 15924, 5405, 2126, 16, 1930, 3425, 13564, 2405, 22834, 7969, 1918, 18, 5809, 9089, 1940, 3]}]}
{"query": {"id": "q_2929", "content": "Steinert's disease [SEP] e B-cell gastric lymphoma in a patient with myotonic dystrophy (Steinert's disease).", "tokenized_content": [2, 21557, 3062, 11, 61, 2573, 3, 47, 44, 17, 2024, 6319, 8636, 1922, 43, 2774, 1956, 15924, 24970, 19321, 12, 21557, 3062, 11, 61, 2573, 13, 18, 3]}, "items": [{"id": "p_2929", "content": "Myotonic Dystrophy [SEP] Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLEC", "score": 1, "type": null, "tokenized_content": [2, 15924, 24970, 19321, 3, 15829, 4770, 4378, 2007, 7529, 12330, 10260, 31, 15924, 5405, 2126, 16, 1930, 3425, 13564, 2405, 22834, 7969, 1918, 18, 5809, 9089, 1940, 3]}]}
{"query": {"id": "q_2930", "content": "gastric lymphoma [SEP] authors describe the unusual association between diffuse B-cell gastric lymphoma and myotonic dystrophy, the most common form of adult muscular ", "tokenized_content": [2, 6319, 8636, 3, 3875, 5993, 1920, 12236, 3279, 2192, 9435, 44, 17, 2024, 6319, 8636, 1930, 15924, 24970, 19321, 16, 1920, 2501, 3059, 2386, 1927, 4160, 12330, 3]}, "items": [{"id": "p_2930", "content": "Familial primary gastric lymphoma [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11444, 3065, 6319, 8636, 3, 3]}]}
{"query": {"id": "q_2931", "content": "myotonic dystrophy [SEP] unusual association between diffuse B-cell gastric lymphoma and myotonic dystrophy, the most common form of adult muscular dystrophy, and sudden a", "tokenized_content": [2, 15924, 24970, 19321, 3, 12236, 3279, 2192, 9435, 44, 17, 2024, 6319, 8636, 1930, 15924, 24970, 19321, 16, 1920, 2501, 3059, 2386, 1927, 4160, 12330, 19321, 16, 1930, 12446, 43, 3]}, "items": [{"id": "p_2931", "content": "Myotonic Dystrophy [SEP] Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLEC", "score": 1, "type": null, "tokenized_content": [2, 15924, 24970, 19321, 3, 15829, 4770, 4378, 2007, 7529, 12330, 10260, 31, 15924, 5405, 2126, 16, 1930, 3425, 13564, 2405, 22834, 7969, 1918, 18, 5809, 9089, 1940, 3]}]}
{"query": {"id": "q_2932", "content": "muscular dystrophy [SEP]  lymphoma and myotonic dystrophy, the most common form of adult muscular dystrophy, and sudden atrial fibrillation following one cycle of doxorubi", "tokenized_content": [2, 12330, 19321, 3, 8636, 1930, 15924, 24970, 19321, 16, 1920, 2501, 3059, 2386, 1927, 4160, 12330, 19321, 16, 1930, 12446, 9224, 13671, 2894, 2340, 4048, 1927, 7169, 1924, 2255, 1033, 3]}, "items": [{"id": "p_2932", "content": "Muscular Dystrophies [SEP] A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorize", "score": 1, "type": null, "tokenized_content": [2, 12330, 10612, 2789, 2062, 3, 43, 8538, 2210, 1927, 12911, 15924, 9112, 2062, 16, 4378, 2007, 23217, 1930, 12175, 1927, 1920, 7345, 3760, 18, 2611, 2032, 29502, 3]}]}
{"query": {"id": "q_2933", "content": "atrial fibrillation [SEP] y, the most common form of adult muscular dystrophy, and sudden atrial fibrillation following one cycle of doxorubicin-based chemotherapy in the sa", "tokenized_content": [2, 9224, 13671, 3, 67, 16, 1920, 2501, 3059, 2386, 1927, 4160, 12330, 19321, 16, 1930, 12446, 9224, 13671, 2894, 2340, 4048, 1927, 12377, 17, 2454, 5318, 1922, 1920, 4611, 3]}, "items": [{"id": "p_2933", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2934", "content": "doxorubicin [SEP] ystrophy, and sudden atrial fibrillation following one cycle of doxorubicin-based chemotherapy in the same patient. Atrial fibrillation or ", "tokenized_content": [2, 12377, 3, 24018, 1997, 2688, 1012, 16, 1930, 12446, 9224, 13671, 2894, 2340, 4048, 1927, 12377, 17, 2454, 5318, 1922, 1920, 2841, 2774, 18, 9224, 13671, 2014, 3]}, "items": [{"id": "p_2934", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2935", "content": "Atrial fibrillation [SEP] ne cycle of doxorubicin-based chemotherapy in the same patient. Atrial fibrillation or other cardiac arrhythmias are unusual complications in patie", "tokenized_content": [2, 9224, 13671, 3, 2069, 4048, 1927, 12377, 17, 2454, 5318, 1922, 1920, 2841, 2774, 18, 9224, 13671, 2014, 2303, 4435, 16934, 2032, 12236, 5021, 1922, 2091, 1021, 3]}, "items": [{"id": "p_2935", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2936", "content": "cardiac arrhythmias [SEP]  chemotherapy in the same patient. Atrial fibrillation or other cardiac arrhythmias are unusual complications in patients treated with chemotherapy", "tokenized_content": [2, 4435, 16934, 3, 5318, 1922, 1920, 2841, 2774, 18, 9224, 13671, 2014, 2303, 4435, 16934, 2032, 12236, 5021, 1922, 2132, 2868, 1956, 5318, 3]}, "items": [{"id": "p_2936", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2937", "content": "cardiac toxicity [SEP] nusual complications in patients treated with chemotherapy. The cardiac toxicity intrinsically associated with the aggressive chemotherapy emplo", "tokenized_content": [2, 4435, 5532, 3, 13232, 20490, 1923, 5021, 1922, 2132, 2868, 1956, 5318, 18, 1920, 4435, 5532, 20061, 2458, 1956, 1920, 8704, 5318, 22109, 1037, 3]}, "items": [{"id": "p_2937", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2938", "content": "arrhythmia [SEP] erapy in the same patient. Atrial fibrillation or other cardiac arrhythmias are unusual complications in patients treated with chemotherap", "tokenized_content": [2, 18346, 3, 14821, 13976, 1922, 1920, 2841, 2774, 18, 9224, 13671, 2014, 2303, 4435, 16934, 2032, 12236, 5021, 1922, 2132, 2868, 1956, 12776, 2380, 2026, 3]}, "items": [{"id": "p_2938", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2939", "content": "thalidomide [SEP] A phase II study of thalidomide in advanced metastatic renal cell carcinoma.", "tokenized_content": [2, 30184, 3, 43, 3193, 2890, 2161, 1927, 30184, 1922, 5570, 6476, 4604, 2024, 5373, 18, 3]}, "items": [{"id": "p_2939", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_2940", "content": "renal cell carcinoma [SEP] A phase II study of thalidomide in advanced metastatic renal cell carcinoma.", "tokenized_content": [2, 4604, 2024, 5373, 3, 43, 3193, 2890, 2161, 1927, 30184, 1922, 5570, 6476, 4604, 2024, 5373, 18, 3]}, "items": [{"id": "p_2940", "content": "Carcinoma, Renal Cell [SEP] A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes includin", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 4604, 2024, 3, 43, 8538, 2210, 1927, 13088, 2014, 16321, 5373, 3595, 2037, 2094, 1927, 1920, 11770, 18, 2276, 2032, 2980, 8160, 2327, 1921, 3]}]}
{"query": {"id": "q_2941", "content": "toxicity [SEP] OBJECTIVES: To evaluate the toxicity and activity of thalidomide in patients with advanced metastati", "tokenized_content": [2, 5532, 3, 7634, 30, 1942, 4323, 1920, 5532, 1930, 2455, 1927, 30184, 1922, 2132, 1956, 5570, 4025, 1968, 3]}, "items": [{"id": "p_2941", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2942", "content": "thalidomide [SEP] OBJECTIVES: To evaluate the toxicity and activity of thalidomide in patients with advanced metastatic renal cell cancer and to m", "tokenized_content": [2, 30184, 3, 7634, 30, 1942, 4323, 1920, 5532, 1930, 2455, 1927, 30184, 1922, 2132, 1956, 5570, 6476, 4604, 2024, 2539, 1930, 1942, 55, 3]}, "items": [{"id": "p_2942", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_2943", "content": "renal cell cancer [SEP] nd activity of thalidomide in patients with advanced metastatic renal cell cancer and to measure changes of one angiogenic factor, vascular endot", "tokenized_content": [2, 4604, 2024, 2539, 3, 8026, 2455, 1927, 30184, 1922, 2132, 1956, 5570, 6476, 4604, 2024, 2539, 1930, 1942, 2931, 2840, 1927, 2340, 12489, 2991, 16, 4541, 16239, 1031, 3]}, "items": [{"id": "p_2943", "content": "Carcinoma, Renal Cell [SEP] A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes includin", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 4604, 2024, 3, 43, 8538, 2210, 1927, 13088, 2014, 16321, 5373, 3595, 2037, 2094, 1927, 1920, 11770, 18, 2276, 2032, 2980, 8160, 2327, 1921, 3]}]}
{"query": {"id": "q_2944", "content": "metastases [SEP] e of 11 months duration of a patient with hepatic and pulmonary metastases (4%), one minor response, and 2 patients stable for over 6 mont", "tokenized_content": [2, 8174, 3, 47, 1927, 2513, 3221, 4392, 1927, 43, 2774, 1956, 6095, 1930, 5352, 8174, 12, 24, 9, 13, 16, 2340, 5857, 2644, 16, 1930, 22, 2132, 4700, 1958, 2338, 3]}, "items": [{"id": "p_2944", "content": "Neoplasm Metastasis [SEP] The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12132, 5967, 3, 1920, 3856, 1927, 43, 12132, 2037, 2340, 3090, 2014, 3131, 1927, 1920, 3362, 1942, 3741, 12597, 2037, 1920, 3065, 3200, 18, 3]}]}
{"query": {"id": "q_2945", "content": "Somnolence [SEP] ), one minor response, and 2 patients stable for over 6 months. Somnolence and constipation were prominent toxicities and most patients co", "tokenized_content": [2, 5714, 11873, 15253, 1972, 3, 13, 16, 2340, 5857, 2644, 16, 1930, 22, 2132, 4700, 1958, 2338, 26, 3221, 18, 5714, 11873, 15253, 1972, 1930, 19618, 1985, 8753, 15251, 1930, 3]}, "items": [{"id": "p_2945", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_2946", "content": "constipation [SEP] sponse, and 2 patients stable for over 6 months. Somnolence and constipation were prominent toxicities and most patients could not tolerate ", "tokenized_content": [2, 19618, 3, 15312, 1021, 16, 1930, 22, 2132, 4700, 1958, 2338, 26, 3221, 18, 5714, 11873, 15253, 1972, 1930, 19618, 1985, 8753, 15251, 1930, 2501, 2132, 2578, 2084, 21407, 3]}, "items": [{"id": "p_2946", "content": "Constipation [SEP] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER", "score": 1, "type": null, "tokenized_content": [2, 19618, 3, 21587, 2014, 4571, 30034, 1927, 18610, 18, 2144, 3601, 2032, 2458, 1956, 43, 5386, 1927, 5092, 16, 2710, 2330, 6096, 6832, 3]}]}
{"query": {"id": "q_2947", "content": "toxicities [SEP] e for over 6 months. Somnolence and constipation were prominent toxicities and most patients could not tolerate the 1200 mg/day dose level", "tokenized_content": [2, 15251, 3, 47, 1958, 2338, 26, 3221, 18, 5714, 11873, 15253, 1972, 1930, 19618, 1985, 8753, 15251, 1930, 2501, 2132, 2578, 2084, 21407, 1920, 16991, 2786, 19, 3007, 3253, 2237, 3]}, "items": [{"id": "p_2947", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2948", "content": "renal cell carcinoma [SEP] s are consistent with a low level of activity of thalidomide in renal cell carcinoma. Administration of doses over 800 mg/day was difficult to achie", "tokenized_content": [2, 4604, 2024, 5373, 3, 61, 2032, 3499, 1956, 43, 2330, 2237, 1927, 2455, 1927, 30184, 1922, 4604, 2024, 5373, 18, 4183, 1927, 5312, 2338, 9658, 2786, 19, 3007, 1982, 4571, 3]}, "items": [{"id": "p_2948", "content": "Carcinoma, Renal Cell [SEP] A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes includin", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 4604, 2024, 3, 43, 8538, 2210, 1927, 13088, 2014, 16321, 5373, 3595, 2037, 2094, 1927, 1920, 11770, 18, 2276, 2032, 2980, 8160, 2327, 1921, 3]}]}
{"query": {"id": "q_2949", "content": "glutamate [SEP] tagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors.", "tokenized_content": [2, 7627, 3, 5218, 13339, 2156, 1927, 17495, 1009, 16, 2308, 2084, 1925, 7829, 1927, 2210, 2890, 18447, 8405, 7627, 4086, 18, 3]}, "items": [{"id": "p_2949", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_2950", "content": "Haloperidol [SEP] triatum, are involved in antiparkinsonian-like effects in rats. Haloperidol (1 mg/kg ip) induced parkinsonian-like muscle rigidity, measure", "tokenized_content": [2, 25107, 3, 5083, 9576, 16, 2032, 3286, 1922, 24290, 14488, 6114, 1022, 17, 3189, 2564, 1922, 3615, 18, 25107, 12, 21, 2786, 19, 3621, 5416, 13, 2719, 10124, 3122, 17, 3]}, "items": [{"id": "p_2950", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2951", "content": "parkinsonian [SEP] group II mGluRs, localized in the striatum, are involved in antiparkinsonian-like effects in rats. Haloperidol (1 mg/kg ip) induced parkinso", "tokenized_content": [2, 10124, 3122, 3, 2210, 2890, 17495, 1036, 16, 6579, 1922, 1920, 11259, 16, 2032, 3286, 1922, 24290, 14488, 6114, 1022, 17, 3189, 2564, 1922, 3615, 18, 25107, 12, 21, 2786, 3]}, "items": [{"id": "p_2951", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2952", "content": "muscle rigidity [SEP] cts in rats. Haloperidol (1 mg/kg ip) induced parkinsonian-like muscle rigidity, measured as an increased resistance of a rat's hind foot to pa", "tokenized_content": [2, 3760, 20471, 3, 15359, 1922, 3615, 18, 25107, 12, 21, 2786, 19, 3621, 5416, 13, 2719, 10124, 3122, 17, 3189, 3760, 20471, 16, 3045, 1966, 1925, 2502, 3554, 1927, 43, 3]}, "items": [{"id": "p_2952", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_2953", "content": "(RS)-1-aminoindan-1,5-dicarboxylic acid [SEP]  hind foot to passive flexion and extension at the ankle joint. (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; 0.5-15 microg/0.5 microl), a potent and selective mGluR1", "tokenized_content": [2, 12, 4366, 13, 17, 21, 17, 3835, 2762, 1928, 17, 21, 16, 25, 17, 9192, 26431, 2687, 3, 8858, 8135, 1942, 9832, 13326, 1930, 7140, 2019, 1920, 13024, 6047, 18, 3]}, "items": [{"id": "p_2953", "content": "1-aminoindan-1,5-dicarboxylic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 3835, 2762, 1928, 17, 21, 16, 25, 17, 9192, 26431, 2687, 3, 3]}]}
{"query": {"id": "q_2954", "content": "AIDA [SEP] on at the ankle joint. (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; 0.5-15 microg/0.5 microl), a potent and selective mGluR1 antag", "tokenized_content": [2, 8379, 1019, 3, 1990, 2019, 1920, 13024, 6047, 18, 12, 4366, 13, 17, 21, 17, 3835, 2762, 1928, 17, 21, 16, 25, 17, 9192, 26431, 2687, 12, 8379, 1019, 31, 3]}, "items": [{"id": "p_2954", "content": "1-aminoindan-1,5-dicarboxylic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 3835, 2762, 1928, 17, 21, 16, 25, 17, 9192, 26431, 2687, 3, 3]}]}
{"query": {"id": "q_2955", "content": "(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate [SEP] icrog/0.5 microl), a potent and selective mGluR1 antagonist, or (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC; 7.5-15 microg/0.5 microl), a selective group II ag", "tokenized_content": [2, 12, 19805, 16, 30414, 13, 17, 24, 17, 3835, 18425, 2226, 5802, 17, 22, 16, 24, 17, 9192, 15441, 2010, 3, 19778, 2021, 19, 20, 18, 25, 16262, 13, 16, 3]}, "items": [{"id": "p_2955", "content": "4-aminopyrrolidine-2,4-dicarboxylic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 3835, 18425, 2226, 5802, 17, 22, 16, 24, 17, 9192, 26431, 2687, 3, 3]}]}
{"query": {"id": "q_2956", "content": "2R,4R-APDC [SEP] R1 antagonist, or (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC; 7.5-15 microg/0.5 microl), a selective group II agonist, was i", "tokenized_content": [2, 19805, 16, 30414, 17, 23313, 1030, 3, 12041, 8151, 16, 2014, 12, 19805, 16, 30414, 13, 17, 24, 17, 3835, 18425, 2226, 5802, 17, 22, 16, 24, 17, 9192, 15441, 3]}, "items": [{"id": "p_2956", "content": "4-aminopyrrolidine-2,4-dicarboxylic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 3835, 18425, 2226, 5802, 17, 22, 16, 24, 17, 9192, 26431, 2687, 3, 3]}]}
{"query": {"id": "q_2957", "content": "haloperidol [SEP] group II agonist, was injected bilaterally into the striatum of haloperidol-treated animals. AIDA in doses of 7.5-15 microg/0.5 microl dimi", "tokenized_content": [2, 25107, 3, 2210, 2890, 7829, 16, 1982, 5624, 19092, 2460, 1920, 11259, 1927, 25107, 17, 2868, 3555, 18, 8379, 1019, 1922, 5312, 1927, 27, 18, 25, 17, 2461, 12517, 19, 3]}, "items": [{"id": "p_2957", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2958", "content": "cholestatic [SEP] Acute cholestatic hepatitis after exposure to isoflurane.", "tokenized_content": [2, 21211, 2479, 3, 3939, 21211, 2479, 7977, 2256, 3395, 1942, 15362, 18, 3]}, "items": [{"id": "p_2958", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_2959", "content": "hepatitis [SEP] Acute cholestatic hepatitis after exposure to isoflurane.", "tokenized_content": [2, 7977, 3, 3939, 21211, 2479, 7977, 2256, 3395, 1942, 15362, 18, 3]}, "items": [{"id": "p_2959", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2960", "content": "isoflurane [SEP] Acute cholestatic hepatitis after exposure to isoflurane.", "tokenized_content": [2, 15362, 3, 3939, 21211, 2479, 7977, 2256, 3395, 1942, 15362, 18, 3]}, "items": [{"id": "p_2960", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_2961", "content": "cholestatic [SEP] OBJECTIVE: To report a case of acute cholestatic hepatitis following exposure to the inhalational anesthetic iso", "tokenized_content": [2, 21211, 2479, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 3939, 21211, 2479, 7977, 2894, 3395, 1942, 1920, 14728, 1923, 16111, 4911, 3]}, "items": [{"id": "p_2961", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_2962", "content": "hepatitis [SEP] OBJECTIVE: To report a case of acute cholestatic hepatitis following exposure to the inhalational anesthetic isoflurane. C", "tokenized_content": [2, 7977, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 3939, 21211, 2479, 7977, 2894, 3395, 1942, 1920, 14728, 1923, 16111, 15362, 18, 45, 3]}, "items": [{"id": "p_2962", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2963", "content": "isoflurane [SEP] tic hepatitis following exposure to the inhalational anesthetic isoflurane. CASE SUMMARY: A 70-year-old healthy woman from Iraq developed ", "tokenized_content": [2, 15362, 3, 18298, 7977, 2894, 3395, 1942, 1920, 14728, 1923, 16111, 15362, 18, 3087, 6099, 30, 43, 3895, 17, 2476, 17, 4156, 4097, 10440, 2037, 3166, 15287, 3530, 3]}, "items": [{"id": "p_2963", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_2964", "content": "dipyrone [SEP] ses of hepatitis. No other medications were involved except for dipyrone for analgesia. The alanine aminotransferase was elevated to a p", "tokenized_content": [2, 9137, 5134, 2912, 3, 9924, 1927, 7977, 18, 2239, 2303, 7719, 1985, 3286, 5574, 1958, 9137, 5134, 2912, 1958, 14695, 18, 1920, 10504, 15817, 1982, 4664, 1942, 43, 58, 3]}, "items": [{"id": "p_2964", "content": "Dipyrone [SEP] A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of ", "score": 1, "type": null, "tokenized_content": [2, 9137, 5134, 2912, 3, 43, 2838, 1988, 2258, 14501, 16, 2246, 17, 3769, 16, 1930, 2246, 18425, 3023, 3879, 18, 2176, 1977, 1920, 5227, 26265, 2010, 1927, 3835, 18425, 2053, 18, 2882, 1927, 3]}]}
{"query": {"id": "q_2965", "content": "analgesia [SEP] tis. No other medications were involved except for dipyrone for analgesia. The alanine aminotransferase was elevated to a peak concentrat", "tokenized_content": [2, 14695, 3, 30152, 18, 2239, 2303, 7719, 1985, 3286, 5574, 1958, 9137, 5134, 2912, 1958, 14695, 18, 1920, 10504, 15817, 1982, 4664, 1942, 43, 3833, 2587, 1926, 3]}, "items": [{"id": "p_2965", "content": "Pain Insensitivity, Congenital [SEP] A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent cor", "score": 1, "type": null, "tokenized_content": [2, 3594, 30055, 16, 9901, 3, 43, 4741, 4378, 2007, 2063, 11307, 2055, 1942, 3594, 4281, 1920, 3682, 1942, 7279, 24218, 2037, 2447, 17, 24218, 5458, 18, 7685, 2233, 3]}]}
{"query": {"id": "q_2966", "content": "alanine [SEP] edications were involved except for dipyrone for analgesia. The alanine aminotransferase was elevated to a peak concentration of 1533 U", "tokenized_content": [2, 10504, 3, 3347, 15270, 1985, 3286, 5574, 1958, 9137, 5134, 2912, 1958, 14695, 18, 1920, 10504, 15817, 1982, 4664, 1942, 43, 3833, 3110, 1927, 13751, 1010, 63, 3]}, "items": [{"id": "p_2966", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_2967", "content": "bilirubin [SEP]  was elevated to a peak concentration of 1533 U/L and the serum bilirubin reached a peak of 17.0 mg/dL. There was slow improvement over 4", "tokenized_content": [2, 15702, 3, 1982, 4664, 1942, 43, 3833, 3110, 1927, 13751, 1010, 63, 19, 54, 1930, 1920, 3256, 15702, 6690, 43, 3833, 1927, 2752, 18, 20, 2786, 19, 5268, 18, 2276, 3]}, "items": [{"id": "p_2967", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_2968", "content": "halothane hepatitis [SEP] ION: The clinical and histologic picture of this case resembles halothane hepatitis, which has a significant mortality rate. CONCLUSIONS: Isofluran", "tokenized_content": [2, 23226, 1963, 2516, 7977, 3, 4755, 30, 1920, 2535, 1930, 12434, 10213, 1927, 2052, 3087, 17602, 23226, 1963, 2516, 7977, 16, 2154, 2258, 43, 2228, 3885, 2769, 18, 4355, 30, 3]}, "items": [{"id": "p_2968", "content": "Halothane Hepatitis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 7977, 3, 3]}]}
{"query": {"id": "q_2969", "content": "Isoflurane [SEP] hepatitis, which has a significant mortality rate. CONCLUSIONS: Isoflurane, a common anesthetic agent, can cause severe cholestatic hepati", "tokenized_content": [2, 15362, 3, 7977, 16, 2154, 2258, 43, 2228, 3885, 2769, 18, 4355, 30, 15362, 16, 43, 3059, 16111, 5899, 16, 2112, 3936, 4010, 21211, 2479, 5746, 1033, 3]}, "items": [{"id": "p_2969", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_2970", "content": "nitric oxide [SEP] Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache", "tokenized_content": [2, 10233, 7491, 3, 26406, 2359, 17, 2712, 4207, 2428, 2409, 10233, 7491, 17, 2719, 12187, 1922, 2132, 1956, 3724, 10146, 17, 2601, 12187, 3]}, "items": [{"id": "p_2970", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2971", "content": "headache [SEP] citonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache.", "tokenized_content": [2, 12187, 3, 12366, 6655, 2359, 17, 2712, 4207, 2428, 2409, 10233, 7491, 17, 2719, 12187, 1922, 2132, 1956, 3724, 10146, 17, 2601, 12187, 18, 3]}, "items": [{"id": "p_2971", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2972", "content": "tension-type headache [SEP] s during nitric oxide-induced headache in patients with chronic tension-type headache.", "tokenized_content": [2, 10146, 17, 2601, 12187, 3, 61, 2409, 10233, 7491, 17, 2719, 12187, 1922, 2132, 1956, 3724, 10146, 17, 2601, 12187, 18, 3]}, "items": [{"id": "p_2972", "content": "Tension-Type Headache [SEP] A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to mo", "score": 1, "type": null, "tokenized_content": [2, 10146, 17, 2601, 12187, 3, 43, 3059, 3065, 12187, 4770, 16, 4378, 2007, 43, 13247, 1024, 16, 2447, 17, 25960, 16, 9435, 16, 5472, 17, 3189, 12, 2014, 15537, 17, 3189, 13, 3594, 1927, 5809, 1942, 2661, 3]}]}
{"query": {"id": "q_2973", "content": "nitric oxide [SEP] It has been proposed that nitric oxide (NO) induced headache in primary headaches may be associated wi", "tokenized_content": [2, 10233, 7491, 3, 2176, 2258, 2252, 4211, 1988, 10233, 7491, 12, 2239, 13, 2719, 12187, 1922, 3065, 24339, 2278, 1998, 2458, 11980, 3]}, "items": [{"id": "p_2973", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2974", "content": "NO [SEP] It has been proposed that nitric oxide (NO) induced headache in primary headaches may be associated with r", "tokenized_content": [2, 2239, 3, 2176, 2258, 2252, 4211, 1988, 10233, 7491, 12, 2239, 13, 2719, 12187, 1922, 3065, 24339, 2278, 1998, 2458, 1956, 60, 3]}, "items": [{"id": "p_2974", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2975", "content": "headache [SEP] It has been proposed that nitric oxide (NO) induced headache in primary headaches may be associated with release of calciton", "tokenized_content": [2, 12187, 3, 2176, 2258, 2252, 4211, 1988, 10233, 7491, 12, 2239, 13, 2719, 12187, 1922, 3065, 24339, 2278, 1998, 2458, 1956, 4012, 1927, 20400, 1916, 3]}, "items": [{"id": "p_2975", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2976", "content": "primary headaches [SEP] It has been proposed that nitric oxide (NO) induced headache in primary headaches may be associated with release of calcitonin gene-related pepti", "tokenized_content": [2, 3065, 24339, 3, 2176, 2258, 2252, 4211, 1988, 10233, 7491, 12, 2239, 13, 2719, 12187, 1922, 3065, 24339, 2278, 1998, 2458, 1956, 4012, 1927, 26406, 2359, 17, 2712, 23045, 1033, 3]}, "items": [{"id": "p_2976", "content": "Headache Disorders, Primary [SEP] Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12187, 4414, 16, 3065, 3, 2961, 1922, 2154, 1920, 3065, 3226, 1977, 12187, 1930, 1920, 12187, 5156, 1998, 6898, 1942, 2967, 3171, 5092, 18, 3]}]}
{"query": {"id": "q_2977", "content": "glyceryl trinitrate [SEP] e plasma levels of CGRP during headache induced by the NO donor glyceryl trinitrate (GTN) in 16 patients with chronic tension-type headache and 16 ", "tokenized_content": [2, 7757, 2199, 23501, 26813, 3, 47, 3582, 2428, 1927, 20468, 2409, 12187, 2719, 2007, 1920, 2239, 6282, 7757, 2199, 23501, 26813, 12, 4637, 1022, 13, 1922, 2641, 2132, 1956, 3724, 3]}, "items": [{"id": "p_2977", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_2978", "content": "GTN [SEP] RP during headache induced by the NO donor glyceryl trinitrate (GTN) in 16 patients with chronic tension-type headache and 16 healt", "tokenized_content": [2, 4637, 1022, 3, 4822, 2409, 12187, 2719, 2007, 1920, 2239, 6282, 7757, 2199, 23501, 26813, 12, 4637, 1022, 13, 1922, 2641, 2132, 1956, 3724, 10146, 17, 2601, 12187, 1930, 2641, 3]}, "items": [{"id": "p_2978", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_2979", "content": "tension-type headache [SEP]  NO donor glyceryl trinitrate (GTN) in 16 patients with chronic tension-type headache and 16 healthy controls. The subjects were randomly allocated t", "tokenized_content": [2, 10146, 17, 2601, 12187, 3, 2239, 6282, 7757, 2199, 23501, 26813, 12, 4637, 1022, 13, 1922, 2641, 2132, 1956, 3724, 10146, 17, 2601, 12187, 1930, 2641, 4097, 3562, 18, 1920, 3]}, "items": [{"id": "p_2979", "content": "Tension-Type Headache [SEP] A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to mo", "score": 1, "type": null, "tokenized_content": [2, 10146, 17, 2601, 12187, 3, 43, 3059, 3065, 12187, 4770, 16, 4378, 2007, 43, 13247, 1024, 16, 2447, 17, 25960, 16, 9435, 16, 5472, 17, 3189, 12, 2014, 15537, 17, 3189, 13, 3594, 1927, 5809, 1942, 2661, 3]}]}
{"query": {"id": "q_2980", "content": "Myocardial ischemia [SEP] Myocardial ischemia due to coronary artery spasm during dobutamine stress echocardi", "tokenized_content": [2, 6497, 7716, 3, 6497, 7716, 2810, 1942, 5846, 5511, 24431, 2409, 2608, 16119, 3812, 3071, 9877, 3]}, "items": [{"id": "p_2980", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_2981", "content": "coronary artery spasm [SEP] Myocardial ischemia due to coronary artery spasm during dobutamine stress echocardiography.", "tokenized_content": [2, 5846, 5511, 24431, 3, 6497, 7716, 2810, 1942, 5846, 5511, 24431, 2409, 2608, 16119, 3812, 3071, 12814, 18, 3]}, "items": [{"id": "p_2981", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_2982", "content": "dobutamine [SEP] Myocardial ischemia due to coronary artery spasm during dobutamine stress echocardiography.", "tokenized_content": [2, 2608, 16119, 3812, 3, 6497, 7716, 2810, 1942, 5846, 5511, 24431, 2409, 2608, 16119, 3812, 3071, 12814, 18, 3]}, "items": [{"id": "p_2982", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_2983", "content": "Dobutamine [SEP] Dobutamine stress echocardiography (DSE) is a useful and safe provocation ", "tokenized_content": [2, 2608, 16119, 3812, 3, 2608, 16119, 3812, 3071, 12814, 12, 4473, 1021, 13, 1977, 43, 4707, 1930, 7672, 2463, 5980, 3]}, "items": [{"id": "p_2983", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_2984", "content": "myocardial ischemia [SEP] chocardiography (DSE) is a useful and safe provocation test for myocardial ischemia. Until now, the test has been focused only on the organic lesio", "tokenized_content": [2, 6497, 7716, 3, 4551, 15339, 7408, 3796, 12, 4473, 1021, 13, 1977, 43, 4707, 1930, 7672, 2463, 5980, 2648, 1958, 6497, 7716, 18, 4801, 5195, 16, 1920, 2648, 2258, 2252, 3]}, "items": [{"id": "p_2984", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_2985", "content": "coronary artery stenosis [SEP] nd positive DSE has indicated the presence of significant fixed coronary artery stenosis. The aim of the present study is to examine whether myocardial ", "tokenized_content": [2, 5846, 5511, 10407, 3, 8026, 2843, 4473, 1021, 2258, 3391, 1920, 2990, 1927, 2228, 4779, 5846, 5511, 10407, 18, 1920, 3774, 1927, 1920, 2481, 2161, 1977, 1942, 5020, 3053, 6497, 3]}, "items": [{"id": "p_2985", "content": "Coronary Stenosis [SEP] Narrowing or constriction of a coronary artery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10407, 3, 21005, 2014, 19837, 1927, 43, 5846, 5511, 18, 3]}]}
{"query": {"id": "q_2986", "content": "coronary spasm [SEP]  present study is to examine whether myocardial ischemia due to coronary spasm is induced by dobutamine. We performed DSE on 51 patients with ", "tokenized_content": [2, 5846, 24431, 3, 2481, 2161, 1977, 1942, 5020, 3053, 6497, 7716, 2810, 1942, 5846, 24431, 1977, 2719, 2007, 2608, 16119, 3812, 18, 2038, 2593, 4473, 1021, 1990, 4892, 2132, 1956, 3]}, "items": [{"id": "p_2986", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_2987", "content": "dobutamine [SEP] whether myocardial ischemia due to coronary spasm is induced by dobutamine. We performed DSE on 51 patients with coronary spastic angina b", "tokenized_content": [2, 2608, 16119, 3812, 3, 3053, 6497, 7716, 2810, 1942, 5846, 24431, 1977, 2719, 2007, 2608, 16119, 3812, 18, 2038, 2593, 4473, 1021, 1990, 4892, 2132, 1956, 5846, 21817, 16961, 44, 3]}, "items": [{"id": "p_2987", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_2988", "content": "coronary spastic angina [SEP]  is induced by dobutamine. We performed DSE on 51 patients with coronary spastic angina but without significant fixed coronary artery stenosis. All pat", "tokenized_content": [2, 5846, 21817, 16961, 3, 1977, 2719, 2007, 2608, 16119, 3812, 18, 2038, 2593, 4473, 1021, 1990, 4892, 2132, 1956, 5846, 21817, 16961, 2308, 2979, 2228, 4779, 5846, 5511, 10407, 18, 3]}, "items": [{"id": "p_2988", "content": "Angina Pectoris, Variant [SEP] A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in th", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 16, 6031, 3, 43, 2535, 4741, 4378, 2007, 1920, 2740, 1927, 8475, 3594, 2019, 6172, 1956, 8537, 6809, 1955, 5367, 8644, 1922, 1913, 3]}]}
{"query": {"id": "q_2989", "content": "anginal [SEP] ut significant fixed coronary artery stenosis. All patients had anginal attacks at rest with ST elevation on the electrocardiogram (var", "tokenized_content": [2, 16961, 1024, 3, 11112, 2228, 4779, 5846, 5511, 10407, 18, 2136, 2132, 2430, 16961, 1024, 15413, 2019, 6172, 1956, 1955, 8644, 1990, 1920, 22477, 12, 4953, 3]}, "items": [{"id": "p_2989", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_2990", "content": "variant angina [SEP] nal attacks at rest with ST elevation on the electrocardiogram (variant angina). Coronary spasm was induced by intracoronary injection of acet", "tokenized_content": [2, 6031, 16961, 3, 13120, 15413, 2019, 6172, 1956, 1955, 8644, 1990, 1920, 22477, 12, 6031, 16961, 13, 18, 5846, 24431, 1982, 2719, 2007, 4245, 30515, 2141, 4107, 1927, 4118, 3]}, "items": [{"id": "p_2990", "content": "Angina Pectoris, Variant [SEP] A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in th", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 16, 6031, 3, 43, 2535, 4741, 4378, 2007, 1920, 2740, 1927, 8475, 3594, 2019, 6172, 1956, 8537, 6809, 1955, 5367, 8644, 1922, 1913, 3]}]}
{"query": {"id": "q_2991", "content": "acetylcholine [SEP] gina). Coronary spasm was induced by intracoronary injection of acetylcholine, and no fixed coronary artery stenosis was documented on angiog", "tokenized_content": [2, 14561, 3, 7217, 2175, 13, 18, 5846, 24431, 1982, 2719, 2007, 4245, 30515, 2141, 4107, 1927, 14561, 16, 1930, 2239, 4779, 5846, 5511, 10407, 1982, 6974, 1990, 29220, 1029, 3]}, "items": [{"id": "p_2991", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_2992", "content": "chest pain [SEP] s showed asynergy with ST elevation. All 7 patients (13.7%) had chest pain during asynergy, and both chest pain and electrocardiographic c", "tokenized_content": [2, 8475, 3594, 3, 61, 2594, 1966, 17151, 1005, 26983, 1956, 1955, 8644, 18, 2136, 27, 2132, 12, 2590, 18, 27, 9, 13, 2430, 8475, 3594, 2409, 1966, 17151, 1005, 26983, 3]}, "items": [{"id": "p_2992", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_2993", "content": "coronary artery disease [SEP] with coronary spastic angina. When DSE is performed to evaluate coronary artery disease, not only fixed coronary stenosis, but also coronary spasm shou", "tokenized_content": [2, 5846, 5511, 2573, 3, 1956, 5846, 21817, 16961, 18, 2469, 4473, 1021, 1977, 2593, 1942, 4323, 5846, 5511, 2573, 16, 2084, 2444, 4779, 5846, 10407, 16, 2308, 2222, 5846, 24431, 3]}, "items": [{"id": "p_2993", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_2994", "content": "coronary stenosis [SEP] s performed to evaluate coronary artery disease, not only fixed coronary stenosis, but also coronary spasm should be considered as a genesis of a", "tokenized_content": [2, 5846, 10407, 3, 61, 2593, 1942, 4323, 5846, 5511, 2573, 16, 2084, 2444, 4779, 5846, 10407, 16, 2308, 2222, 5846, 24431, 3066, 1998, 3311, 1966, 43, 25309, 1927, 43, 3]}, "items": [{"id": "p_2994", "content": "Coronary Stenosis [SEP] Narrowing or constriction of a coronary artery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10407, 3, 21005, 2014, 19837, 1927, 43, 5846, 5511, 18, 3]}]}
{"query": {"id": "q_2995", "content": "Nitric oxide [SEP] Nitric oxide synthase expression in the course of lead-induced hypertension.", "tokenized_content": [2, 10233, 7491, 3, 10233, 7491, 8921, 2294, 1922, 1920, 4914, 1927, 2949, 17, 2719, 5579, 18, 3]}, "items": [{"id": "p_2995", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2996", "content": "lead [SEP] Nitric oxide synthase expression in the course of lead-induced hypertension.", "tokenized_content": [2, 2949, 3, 10233, 7491, 8921, 2294, 1922, 1920, 4914, 1927, 2949, 17, 2719, 5579, 18, 3]}, "items": [{"id": "p_2996", "content": "Lead [SEP] A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)\n    ", "score": 1, "type": null, "tokenized_content": [2, 2949, 3, 43, 3793, 16, 7984, 2471, 6048, 1956, 15501, 2080, 16028, 31, 11241, 2529, 6175, 16, 11241, 3388, 18063, 18, 2282, 16, 17530, 5242, 18, 12, 19638, 4702, 16, 3158, 1963, 13, 3]}]}
{"query": {"id": "q_2997", "content": "hypertension [SEP] Nitric oxide synthase expression in the course of lead-induced hypertension.", "tokenized_content": [2, 5579, 3, 10233, 7491, 8921, 2294, 1922, 1920, 4914, 1927, 2949, 17, 2719, 5579, 18, 3]}, "items": [{"id": "p_2997", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2998", "content": "oxygen [SEP] We recently showed elevated reactive oxygen species (ROS), reduced urinary excretion of NO metabolites (NOx", "tokenized_content": [2, 4612, 3, 2038, 3998, 2594, 4664, 6079, 4612, 3038, 12, 4742, 13, 16, 3028, 7075, 11093, 1927, 2239, 6926, 12, 12792, 3]}, "items": [{"id": "p_2998", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_2999", "content": "NO [SEP] ted reactive oxygen species (ROS), reduced urinary excretion of NO metabolites (NOx), and increased NO sequestration as nitrotyros", "tokenized_content": [2, 2239, 3, 26080, 6079, 4612, 3038, 12, 4742, 13, 16, 3028, 7075, 11093, 1927, 2239, 6926, 12, 12792, 13, 16, 1930, 2502, 2239, 19001, 1966, 8686, 3145, 2263, 3]}, "items": [{"id": "p_2999", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_3000", "content": "nitrotyrosine [SEP] tion of NO metabolites (NOx), and increased NO sequestration as nitrotyrosine in various tissues in rats with lead-induced hypertension. This", "tokenized_content": [2, 8686, 3145, 20580, 3, 8685, 1916, 1927, 2239, 6926, 12, 12792, 13, 16, 1930, 2502, 2239, 19001, 1966, 8686, 3145, 20580, 1922, 3425, 3878, 1922, 3615, 1956, 2949, 17, 2719, 3]}, "items": [{"id": "p_3000", "content": "3-nitrotyrosine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 8686, 3145, 20580, 3, 3]}]}
{"query": {"id": "q_3001", "content": "lead [SEP]  sequestration as nitrotyrosine in various tissues in rats with lead-induced hypertension. This study was designed to discern whethe", "tokenized_content": [2, 2949, 3, 19001, 1966, 8686, 3145, 20580, 1922, 3425, 3878, 1922, 3615, 1956, 2949, 17, 2719, 5579, 18, 2052, 2161, 1982, 4609, 1942, 18126, 8372, 20536, 3]}, "items": [{"id": "p_3001", "content": "Lead [SEP] A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)\n    ", "score": 1, "type": null, "tokenized_content": [2, 2949, 3, 43, 3793, 16, 7984, 2471, 6048, 1956, 15501, 2080, 16028, 31, 11241, 2529, 6175, 16, 11241, 3388, 18063, 18, 2282, 16, 17530, 5242, 18, 12, 19638, 4702, 16, 3158, 1963, 13, 3]}]}
{"query": {"id": "q_3002", "content": "hypertension [SEP] n as nitrotyrosine in various tissues in rats with lead-induced hypertension. This study was designed to discern whether the reduction in ur", "tokenized_content": [2, 5579, 3, 56, 1966, 8686, 3145, 20580, 1922, 3425, 3878, 1922, 3615, 1956, 2949, 17, 2719, 5579, 18, 2052, 2161, 1982, 4609, 1942, 18126, 3053, 1920, 3378, 1922, 3674, 3]}, "items": [{"id": "p_3002", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3003", "content": "lead acetate [SEP] wley rats were randomly assigned to a lead-treated group (given lead acetate, 100 ppm, in drinking water and regular rat chow), a group give", "tokenized_content": [2, 2949, 7959, 3, 21715, 10676, 3615, 1985, 6266, 6304, 1942, 43, 2949, 17, 2868, 2210, 12, 3258, 2949, 7959, 16, 2813, 8748, 16, 1922, 7444, 3224, 1930, 6314, 3067, 15315, 3]}, "items": [{"id": "p_3003", "content": "lead acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2949, 7959, 3, 3]}]}
{"query": {"id": "q_3004", "content": "vitamin E [SEP] in drinking water and regular rat chow), a group given lead and vitamin E-fortified chow, or a normal control group given either regular ", "tokenized_content": [2, 6111, 47, 3, 1922, 7444, 3224, 1930, 6314, 3067, 15315, 13, 16, 43, 2210, 3258, 2949, 1930, 6111, 47, 17, 17133, 2828, 15315, 16, 2014, 43, 2791, 2285, 2210, 3258, 3]}, "items": [{"id": "p_3004", "content": "Vitamin E [SEP] A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydr", "score": 1, "type": null, "tokenized_content": [2, 6111, 47, 3, 43, 13459, 5690, 2684, 1958, 2136, 21432, 1036, 1930, 21682, 18935, 9356, 1036, 1988, 5987, 4595, 17, 21432, 2455, 18, 2007, 25130, 1927, 1920, 14223, 9698, 3]}]}
{"query": {"id": "q_3005", "content": "malondialdehyde [SEP] or 12 weeks. Tail blood pressure, urinary NOx excretion, plasma malondialdehyde (MDA), and endothelial and inducible NOS (eNOS and iNOS) isotyp", "tokenized_content": [2, 24270, 3, 2014, 2369, 3625, 18, 5281, 2877, 3772, 16, 7075, 12792, 11093, 16, 3582, 24270, 12, 7887, 13, 16, 1930, 5003, 1930, 9376, 9291, 12, 14298, 1930, 10320, 13, 3]}, "items": [{"id": "p_3005", "content": "Malondialdehyde [SEP] The dialdehyde of malonic acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24270, 3, 1920, 7588, 6542, 1927, 3054, 3490, 2687, 18, 3]}]}
{"query": {"id": "q_3006", "content": "MDA [SEP]  blood pressure, urinary NOx excretion, plasma malondialdehyde (MDA), and endothelial and inducible NOS (eNOS and iNOS) isotypes in", "tokenized_content": [2, 7887, 3, 2877, 3772, 16, 7075, 12792, 11093, 16, 3582, 24270, 12, 7887, 13, 16, 1930, 5003, 1930, 9376, 9291, 12, 14298, 1930, 10320, 13, 15436, 1036, 1922, 3]}, "items": [{"id": "p_3006", "content": "Malondialdehyde [SEP] The dialdehyde of malonic acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24270, 3, 1920, 7588, 6542, 1927, 3054, 3490, 2687, 18, 3]}]}
{"query": {"id": "q_3007", "content": "Vitamin E [SEP] cal rise in vascular and renal tissue eNOS and iNOS expression. Vitamin E supplementation ameliorated hypertension, lowered plasma MDA co", "tokenized_content": [2, 6111, 47, 3, 2570, 7164, 1922, 4541, 1930, 4604, 2960, 14298, 1930, 10320, 2294, 18, 6111, 47, 8746, 22085, 5579, 16, 13786, 3582, 7887, 2081, 3]}, "items": [{"id": "p_3007", "content": "Vitamin E [SEP] A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydr", "score": 1, "type": null, "tokenized_content": [2, 6111, 47, 3, 43, 13459, 5690, 2684, 1958, 2136, 21432, 1036, 1930, 21682, 18935, 9356, 1036, 1988, 5987, 4595, 17, 21432, 2455, 18, 2007, 25130, 1927, 1920, 14223, 9698, 3]}]}
{"query": {"id": "q_3008", "content": "valvular heart disease [SEP] Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent e", "tokenized_content": [2, 25025, 4003, 2573, 3, 2565, 1958, 25025, 4003, 2573, 2706, 6603, 1927, 15096, 12353, 3812, 1930, 7473, 14946, 12353, 3812, 2746, 5468, 47, 3]}, "items": [{"id": "p_3008", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_3009", "content": "fenfluramine [SEP] Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent echocardiography before use o", "tokenized_content": [2, 15096, 12353, 3812, 3, 2565, 1958, 25025, 4003, 2573, 2706, 6603, 1927, 15096, 12353, 3812, 1930, 7473, 14946, 12353, 3812, 2746, 5468, 12814, 3119, 2485, 57, 3]}, "items": [{"id": "p_3009", "content": "Fenfluramine [SEP] A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15096, 12353, 3812, 3, 43, 20424, 3500, 2838, 1988, 10535, 2321, 7644, 11153, 5047, 1930, 2463, 18118, 4860, 17, 3434, 11153, 4012, 18, 3]}]}
{"query": {"id": "q_3010", "content": "dexfenfluramine [SEP] Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent echocardiography before use of medication.", "tokenized_content": [2, 7473, 14946, 12353, 3812, 3, 2565, 1958, 25025, 4003, 2573, 2706, 6603, 1927, 15096, 12353, 3812, 1930, 7473, 14946, 12353, 3812, 2746, 5468, 12814, 3119, 2485, 1927, 6093, 18, 3]}, "items": [{"id": "p_3010", "content": "Dexfenfluramine [SEP] The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess an", "score": 1, "type": null, "tokenized_content": [2, 7473, 14946, 12353, 3812, 3, 1920, 61, 17, 15348, 1927, 15096, 12353, 3812, 18, 2176, 1977, 43, 11153, 7829, 1930, 1977, 2251, 1966, 1925, 28976, 8955, 1935, 18, 7945, 15096, 12353, 3812, 16, 2176, 3731, 2084, 7150, 1925, 3]}]}
{"query": {"id": "q_3011", "content": "fenfluramine [SEP] rdiographic surveys suggested that up to 30% to 38% of users of fenfluramine and dexfenfluramine had valvular disease, these drugs were with", "tokenized_content": [2, 15096, 12353, 3812, 3, 8695, 3940, 24772, 9293, 3978, 1988, 2353, 1942, 2627, 9, 1942, 3738, 9, 1927, 6603, 1927, 15096, 12353, 3812, 1930, 7473, 14946, 12353, 3812, 2430, 25025, 3]}, "items": [{"id": "p_3011", "content": "Fenfluramine [SEP] A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15096, 12353, 3812, 3, 43, 20424, 3500, 2838, 1988, 10535, 2321, 7644, 11153, 5047, 1930, 2463, 18118, 4860, 17, 3434, 11153, 4012, 18, 3]}]}
{"query": {"id": "q_3012", "content": "dexfenfluramine [SEP] ys suggested that up to 30% to 38% of users of fenfluramine and dexfenfluramine had valvular disease, these drugs were withdrawn from the marke", "tokenized_content": [2, 7473, 14946, 12353, 3812, 3, 24018, 3978, 1988, 2353, 1942, 2627, 9, 1942, 3738, 9, 1927, 6603, 1927, 15096, 12353, 3812, 1930, 7473, 14946, 12353, 3812, 2430, 25025, 2573, 16, 3]}, "items": [{"id": "p_3012", "content": "Dexfenfluramine [SEP] The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess an", "score": 1, "type": null, "tokenized_content": [2, 7473, 14946, 12353, 3812, 3, 1920, 61, 17, 15348, 1927, 15096, 12353, 3812, 18, 2176, 1977, 43, 11153, 7829, 1930, 1977, 2251, 1966, 1925, 28976, 8955, 1935, 18, 7945, 15096, 12353, 3812, 16, 2176, 3731, 2084, 7150, 1925, 3]}]}
{"query": {"id": "q_3013", "content": "valvular disease [SEP]  to 30% to 38% of users of fenfluramine and dexfenfluramine had valvular disease, these drugs were withdrawn from the market. OBJECTIVE: To dete", "tokenized_content": [2, 25025, 2573, 3, 1942, 2627, 9, 1942, 3738, 9, 1927, 6603, 1927, 15096, 12353, 3812, 1930, 7473, 14946, 12353, 3812, 2430, 25025, 2573, 16, 2144, 4195, 1985, 19540, 2037, 1920, 3]}, "items": [{"id": "p_3013", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_3014", "content": "valvular abnormalities [SEP] e market. OBJECTIVE: To determine the risk for new or worsening valvular abnormalities among users of fenfluramine or dexfenfluramine who underwent ec", "tokenized_content": [2, 25025, 6754, 3, 47, 10878, 18, 4470, 30, 1942, 3415, 1920, 2565, 1958, 2814, 2014, 15473, 25025, 6754, 2706, 6603, 1927, 15096, 12353, 3812, 2014, 7473, 14946, 12353, 3812, 2746, 3]}, "items": [{"id": "p_3014", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_3015", "content": "valvulopathy [SEP] w-up echocardiography. The primary outcome was new or worsening valvulopathy, defined as progression of either aortic or mitral regurgitatio", "tokenized_content": [2, 2326, 1020, 1944, 6522, 3, 65, 17, 2353, 12814, 18, 1920, 3065, 3924, 1982, 2814, 2014, 15473, 2326, 1020, 1944, 6522, 16, 3608, 1966, 4380, 1927, 3108, 7677, 2014, 13868, 3]}, "items": [{"id": "p_3015", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_3016", "content": "mitral regurgitation [SEP] sening valvulopathy, defined as progression of either aortic or mitral regurgitation by at least one degree of severity and disease that met U.S. Fo", "tokenized_content": [2, 13868, 20198, 3, 6964, 1941, 2326, 1020, 1944, 6522, 16, 3608, 1966, 4380, 1927, 3108, 7677, 2014, 13868, 20198, 2007, 2019, 3464, 2340, 4647, 1927, 5155, 1930, 2573, 1988, 2130, 3]}, "items": [{"id": "p_3016", "content": "Mitral Valve Insufficiency [SEP] Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mi", "score": 1, "type": null, "tokenized_content": [2, 13868, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3506, 11887, 2460, 1920, 3506, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 13868, 9509, 18, 2052, 2112, 2949, 1942, 6519, 3]}]}
{"query": {"id": "q_3017", "content": "aortic regurgitation [SEP] t met U.S. Food and Drug Administration criteria (at least mild aortic regurgitation or moderate mitral regurgitation). RESULTS: Two patients (4.3% ", "tokenized_content": [2, 7677, 20198, 3, 62, 2130, 63, 18, 61, 18, 3959, 1930, 2838, 4183, 4164, 12, 2019, 3464, 5809, 7677, 20198, 2014, 5086, 13868, 20198, 13, 18, 2274, 30, 2288, 2132, 3]}, "items": [{"id": "p_3017", "content": "Aortic Valve Insufficiency [SEP] Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to ", "score": 1, "type": null, "tokenized_content": [2, 7677, 9509, 14566, 3, 6598, 2625, 4378, 2007, 1920, 3231, 9893, 1927, 2877, 2037, 1920, 15871, 11859, 3231, 2460, 1920, 3506, 11887, 16, 4523, 1942, 3]}]}
{"query": {"id": "q_3018", "content": "phentermine [SEP]  patients (4.3% [95% CI, 0.6% to 14.8%]) receiving fenfluramine-phentermine developed valvular heart disease. One had baseline bicuspid aor", "tokenized_content": [2, 3037, 7890, 2053, 3, 2132, 12, 24, 18, 23, 9, 37, 3002, 9, 3371, 16, 20, 18, 26, 9, 1942, 2607, 18, 28, 9, 39, 13, 5962, 15096, 12353, 3812, 3]}, "items": [{"id": "p_3018", "content": "Phentermine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been ", "score": 1, "type": null, "tokenized_content": [2, 3037, 7890, 2053, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 20256, 1931, 18996, 18, 2176, 2258, 2252, 3]}]}
{"query": {"id": "q_3019", "content": "valvular heart disease [SEP] I, 0.6% to 14.8%]) receiving fenfluramine-phentermine developed valvular heart disease. One had baseline bicuspid aortic valve and mild aortic regurgi", "tokenized_content": [2, 25025, 4003, 2573, 3, 51, 16, 20, 18, 26, 9, 1942, 2607, 18, 28, 9, 39, 13, 5962, 15096, 12353, 3812, 17, 3037, 7890, 2053, 3530, 25025, 4003, 2573, 18, 3]}, "items": [{"id": "p_3019", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_3020", "content": "bicuspid aortic valve [SEP] -phentermine developed valvular heart disease. One had baseline bicuspid aortic valve and mild aortic regurgitation that progressed to moderate regur", "tokenized_content": [2, 8876, 22166, 7677, 9509, 3, 17, 3037, 7890, 2053, 3530, 25025, 4003, 2573, 18, 2340, 2430, 3703, 8876, 22166, 7677, 9509, 1930, 5809, 7677, 20198, 1988, 15942, 1942, 5086, 2147, 3]}, "items": [{"id": "p_3020", "content": "Bicuspid Aortic Valve [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8876, 22166, 7677, 9509, 3, 3]}]}
{"query": {"id": "q_3021", "content": "aortic insufficiency [SEP] derate regurgitation. The second patient developed new moderate aortic insufficiency. CONCLUSION: Users of diet medications are at risk for valvular", "tokenized_content": [2, 7677, 14566, 3, 3135, 2010, 20198, 18, 1920, 2812, 2774, 3530, 2814, 5086, 7677, 14566, 18, 4180, 30, 6603, 1927, 3986, 7719, 2032, 2019, 2565, 1958, 25025, 3]}, "items": [{"id": "p_3021", "content": "Aortic Valve Insufficiency [SEP] Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to ", "score": 1, "type": null, "tokenized_content": [2, 7677, 9509, 14566, 3, 6598, 2625, 4378, 2007, 1920, 3231, 9893, 1927, 2877, 2037, 1920, 15871, 11859, 3231, 2460, 1920, 3506, 11887, 16, 4523, 1942, 3]}]}
{"query": {"id": "q_3022", "content": "Carboplatin [SEP] Carboplatin toxic effects on the peripheral nervous system of the rat.", "tokenized_content": [2, 20072, 3, 20072, 6161, 2564, 1990, 1920, 5009, 7580, 2433, 1927, 1920, 3067, 18, 3]}, "items": [{"id": "p_3022", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_3023", "content": "carboplatin [SEP] BACKGROUND: The most striking of carboplatin's advantages (CBDCA) over cisplatin (CDDP) is its markedly redu", "tokenized_content": [2, 20072, 3, 3872, 30, 1920, 2501, 9784, 1927, 20072, 11, 61, 8518, 12, 18651, 3375, 13, 2338, 9284, 12, 22854, 13, 1977, 2496, 7686, 2312, 1032, 3]}, "items": [{"id": "p_3023", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_3024", "content": "CBDCA [SEP] BACKGROUND: The most striking of carboplatin's advantages (CBDCA) over cisplatin (CDDP) is its markedly reduced rate of neurotox", "tokenized_content": [2, 18651, 3375, 3, 3872, 30, 1920, 2501, 9784, 1927, 20072, 11, 61, 8518, 12, 18651, 3375, 13, 2338, 9284, 12, 22854, 13, 1977, 2496, 7686, 3028, 2769, 1927, 9124, 2325, 3]}, "items": [{"id": "p_3024", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_3025", "content": "cisplatin [SEP] UND: The most striking of carboplatin's advantages (CBDCA) over cisplatin (CDDP) is its markedly reduced rate of neurotoxic effects. Howe", "tokenized_content": [2, 9284, 3, 3075, 30, 1920, 2501, 9784, 1927, 20072, 11, 61, 8518, 12, 18651, 3375, 13, 2338, 9284, 12, 22854, 13, 1977, 2496, 7686, 3028, 2769, 1927, 20919, 2564, 18, 3]}, "items": [{"id": "p_3025", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3026", "content": "CDDP [SEP] st striking of carboplatin's advantages (CBDCA) over cisplatin (CDDP) is its markedly reduced rate of neurotoxic effects. However, t", "tokenized_content": [2, 22854, 3, 1955, 9784, 1927, 20072, 11, 61, 8518, 12, 18651, 3375, 13, 2338, 9284, 12, 22854, 13, 1977, 2496, 7686, 3028, 2769, 1927, 20919, 2564, 18, 2406, 16, 62, 3]}, "items": [{"id": "p_3026", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3027", "content": "neurotoxic [SEP] s (CBDCA) over cisplatin (CDDP) is its markedly reduced rate of neurotoxic effects. However, the use of CBDCA higher-intensity schedules a", "tokenized_content": [2, 20919, 3, 61, 12, 18651, 3375, 13, 2338, 9284, 12, 22854, 13, 1977, 2496, 7686, 3028, 2769, 1927, 20919, 2564, 18, 2406, 16, 1920, 2485, 1927, 18651, 3375, 2580, 17, 3]}, "items": [{"id": "p_3027", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3028", "content": "peripheral nervous system damage [SEP] therapy may cause some concern about its safety with respect to peripheral nervous system damage. MATERIALS AND METHODS: Two different schedules of CBDCA admini", "tokenized_content": [2, 5009, 7580, 2433, 4293, 3, 3181, 2278, 3936, 2673, 8353, 3001, 2496, 5407, 1956, 5633, 1942, 5009, 7580, 2433, 4293, 18, 4751, 1930, 2860, 30, 2288, 2413, 19811, 1927, 18651, 3]}, "items": [{"id": "p_3028", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_3029", "content": "Neurotoxicity [SEP] .p. twice a week for nine times) were evaluated in Wistar rats. Neurotoxicity was assessed for behavioral (tail-flick test), neurophysiologic", "tokenized_content": [2, 18034, 3, 18, 58, 18, 6470, 43, 2982, 1958, 6360, 3586, 13, 1985, 3747, 1922, 15668, 3615, 18, 18034, 1982, 3683, 1958, 5343, 12, 5281, 17, 26736, 2648, 13, 16, 3]}, "items": [{"id": "p_3029", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3030", "content": "peripheral neurotoxicity [SEP] l effects. RESULTS: CBDCA administration induced dose-dependent peripheral neurotoxicity. Pain perception and nerve conduction velocity in the tail were", "tokenized_content": [2, 5009, 18034, 3, 54, 2564, 18, 2274, 30, 18651, 3375, 4183, 2719, 3253, 17, 3100, 5009, 18034, 18, 3594, 6262, 1930, 5507, 12382, 7227, 1922, 1920, 5281, 1985, 3]}, "items": [{"id": "p_3030", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_3031", "content": "Pain [SEP] administration induced dose-dependent peripheral neurotoxicity. Pain perception and nerve conduction velocity in the tail were signi", "tokenized_content": [2, 3594, 3, 4183, 2719, 3253, 17, 3100, 5009, 18034, 18, 3594, 6262, 1930, 5507, 12382, 7227, 1922, 1920, 5281, 1985, 2105, 1033, 3]}, "items": [{"id": "p_3031", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3032", "content": "platinum [SEP] of ganglionic sensory neurons. Moreover, significant amounts of platinum were detected in the dorsal root ganglia and kidney after CBDCA", "tokenized_content": [2, 13299, 3, 1927, 12516, 1935, 6893, 3558, 18, 3950, 16, 2228, 6222, 1927, 13299, 1985, 3330, 1922, 1920, 7193, 5904, 13086, 1930, 5245, 2256, 18651, 3375, 3]}, "items": [{"id": "p_3032", "content": "Platinum [SEP] Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th e", "score": 1, "type": null, "tokenized_content": [2, 13299, 3, 13299, 18, 43, 7881, 16, 3793, 16, 9495, 2471, 6048, 16, 18994, 12347, 16, 11241, 2529, 5440, 16, 11241, 3388, 16030, 18, 7102, 16, 17530, 4401, 18, 12, 2037, 19638, 4702, 16, 3158, 1963, 47, 3]}]}
{"query": {"id": "q_3033", "content": "neurotoxicity [SEP] RESULTS: CBDCA administration induced dose-dependent peripheral neurotoxicity. Pain perception and nerve conduction velocity in the tail were", "tokenized_content": [2, 18034, 3, 2274, 30, 18651, 3375, 4183, 2719, 3253, 17, 3100, 5009, 18034, 18, 3594, 6262, 1930, 5507, 12382, 7227, 1922, 1920, 5281, 1985, 3]}, "items": [{"id": "p_3033", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3034", "content": "endometrial carcinoma [SEP] Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-contro", "tokenized_content": [2, 11634, 5373, 3, 26674, 7481, 1927, 11634, 5373, 2256, 2311, 1958, 3739, 2539, 1922, 43, 3103, 12941, 3087, 17, 9738, 3]}, "items": [{"id": "p_3034", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_3035", "content": "breast cancer [SEP] Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-control study. F  d  ration Nationale de", "tokenized_content": [2, 3739, 2539, 3, 26674, 7481, 1927, 11634, 5373, 2256, 2311, 1958, 3739, 2539, 1922, 43, 3103, 12941, 3087, 17, 2285, 2161, 18, 48, 46, 12488, 3852, 1021, 2028, 3]}, "items": [{"id": "p_3035", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3036", "content": "tamoxifen [SEP] Since tamoxifen is widely used in breast cancer treatment and has been proposed", "tokenized_content": [2, 13011, 3, 3328, 13011, 1977, 5673, 2251, 1922, 3739, 2539, 2311, 1930, 2258, 2252, 4211, 3]}, "items": [{"id": "p_3036", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_3037", "content": "breast cancer [SEP] Since tamoxifen is widely used in breast cancer treatment and has been proposed for the prevention of breast ca", "tokenized_content": [2, 3739, 2539, 3, 3328, 13011, 1977, 5673, 2251, 1922, 3739, 2539, 2311, 1930, 2258, 2252, 4211, 1958, 1920, 5455, 1927, 3739, 2332, 3]}, "items": [{"id": "p_3037", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3038", "content": "endometrial cancer [SEP] arefully examined. We have investigated the association between endometrial cancer and tamoxifen use or other treatments in women treated for brea", "tokenized_content": [2, 11634, 2539, 3, 2032, 17735, 3572, 18, 2038, 2162, 3845, 1920, 3279, 2192, 11634, 2539, 1930, 13011, 2485, 2014, 2303, 4930, 1922, 3089, 2868, 1958, 3022, 1019, 3]}, "items": [{"id": "p_3038", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_3039", "content": "advanced disease [SEP]  who had endometrial cancer and had received tamoxifen had more advanced disease and poorer prognosis than those with endometrial cancer who had", "tokenized_content": [2, 5570, 2573, 3, 2746, 2430, 11634, 2539, 1930, 2430, 4004, 13011, 2430, 2253, 5570, 2573, 1930, 11667, 6573, 2254, 2690, 1956, 11634, 2539, 2746, 2430, 3]}, "items": [{"id": "p_3039", "content": "Sleep Disorders, Circadian Rhythm [SEP] Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 16, 10507, 11529, 3, 3890, 2204, 18044, 10657, 2458, 1956, 7561, 1927, 1920, 2791, 2686, 6231, 5006, 14763, 4048, 4067, 1942, 10354, 12, 47, 18, 49, 18, 16, 19455, 9333, 4741, 13, 16, 5950, 3]}]}
{"query": {"id": "q_3040", "content": "Endometrial cancers [SEP] e an additional iatrogenic factor for women with breast cancer. Endometrial cancers diagnosed in women treated with tamoxifen have poorer prognosis", "tokenized_content": [2, 11634, 5717, 3, 47, 1925, 3281, 26674, 2991, 1958, 3089, 1956, 3739, 2539, 18, 11634, 5717, 5377, 1922, 3089, 2868, 1956, 13011, 2162, 11667, 6573, 3]}, "items": [{"id": "p_3040", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_3041", "content": "Granulosa cell tumor of the ovary [SEP] Granulosa cell tumor of the ovary associated with antecedent tamoxifen use.", "tokenized_content": [2, 22119, 2024, 2798, 1927, 1920, 13464, 3, 22119, 2024, 2798, 1927, 1920, 13464, 2458, 1956, 25667, 1939, 13011, 2485, 18, 3]}, "items": [{"id": "p_3041", "content": "Granulosa cell tumor of the ovary [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22119, 2024, 2798, 1927, 1920, 13464, 3, 3]}]}
{"query": {"id": "q_3042", "content": "tamoxifen [SEP] Granulosa cell tumor of the ovary associated with antecedent tamoxifen use.", "tokenized_content": [2, 13011, 3, 22119, 2024, 2798, 1927, 1920, 13464, 2458, 1956, 25667, 1939, 13011, 2485, 18, 3]}, "items": [{"id": "p_3042", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_3043", "content": "tamoxifen [SEP] ttention has been focused recently on the estrogenic effects of tamoxifen. Review of the literature reveals an association between tamoxi", "tokenized_content": [2, 13011, 3, 7382, 2546, 2258, 2252, 5625, 3998, 1990, 1920, 29345, 2564, 1927, 13011, 18, 3043, 1927, 1920, 4431, 9179, 1925, 3279, 2192, 9066, 2325, 1033, 3]}, "items": [{"id": "p_3043", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_3044", "content": "tumors [SEP] re reveals an association between tamoxifen use and gynecologic tumors. CASE: A 52-year-old postmenopausal woman was treated with tamo", "tokenized_content": [2, 3861, 3, 1964, 9179, 1925, 3279, 2192, 13011, 2485, 1930, 26557, 3861, 18, 3087, 30, 43, 4764, 17, 2476, 17, 4156, 14285, 10440, 1982, 2868, 1956, 9066, 1037, 3]}, "items": [{"id": "p_3044", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3045", "content": "estrogen [SEP] ACKGROUND: Increased attention has been focused recently on the estrogenic effects of tamoxifen. Review of the literature reveals an ass", "tokenized_content": [2, 7940, 3, 2000, 23254, 3049, 30, 2502, 4976, 2258, 2252, 5625, 3998, 1990, 1920, 29345, 2564, 1927, 13011, 18, 3043, 1927, 1920, 4431, 9179, 1925, 2088, 3]}, "items": [{"id": "p_3045", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_3046", "content": "breast carcinoma [SEP]  treated with tamoxifen for stage II estrogen receptor-positive breast carcinoma. Her aspartate transaminase and alanine transaminase levels inc", "tokenized_content": [2, 3739, 5373, 3, 2868, 1956, 13011, 1958, 3587, 2890, 7940, 3148, 17, 2843, 3739, 5373, 18, 3656, 12878, 24376, 1930, 10504, 24376, 2428, 2043, 3]}, "items": [{"id": "p_3046", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3047", "content": "aspartate [SEP] n for stage II estrogen receptor-positive breast carcinoma. Her aspartate transaminase and alanine transaminase levels increase markedly ", "tokenized_content": [2, 12878, 3, 56, 1958, 3587, 2890, 7940, 3148, 17, 2843, 3739, 5373, 18, 3656, 12878, 24376, 1930, 10504, 24376, 2428, 2760, 7686, 3]}, "items": [{"id": "p_3047", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_3048", "content": "alanine [SEP] eptor-positive breast carcinoma. Her aspartate transaminase and alanine transaminase levels increase markedly after 6 months of tamoxif", "tokenized_content": [2, 10504, 3, 2630, 2684, 17, 2843, 3739, 5373, 18, 3656, 12878, 24376, 1930, 10504, 24376, 2428, 2760, 7686, 2256, 26, 3221, 1927, 9066, 11101, 3]}, "items": [{"id": "p_3048", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_3049", "content": "granulosa cell tumor of the ovary [SEP] d serum transaminases, the patient was found to have a stage Ic granulosa cell tumor of the ovary. CONCLUSION: Patients with tamoxifen-induced liver dysfunction ", "tokenized_content": [2, 22119, 2024, 2798, 1927, 1920, 13464, 3, 46, 3256, 24376, 1036, 16, 1920, 2774, 1982, 2435, 1942, 2162, 43, 3587, 3996, 22119, 2024, 2798, 1927, 1920, 13464, 18, 4180, 30, 3]}, "items": [{"id": "p_3049", "content": "Granulosa cell tumor of the ovary [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22119, 2024, 2798, 1927, 1920, 13464, 3, 3]}]}
{"query": {"id": "q_3050", "content": "liver dysfunction [SEP] tumor of the ovary. CONCLUSION: Patients with tamoxifen-induced liver dysfunction may be at increased risk for granulosa cell tumors because of a", "tokenized_content": [2, 3568, 5273, 3, 2798, 1927, 1920, 13464, 18, 4180, 30, 2132, 1956, 13011, 17, 2719, 3568, 5273, 2278, 1998, 2019, 2502, 2565, 1958, 22119, 2024, 3861, 2882, 1927, 43, 3]}, "items": [{"id": "p_3050", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_3051", "content": "granulosa cell tumors [SEP] amoxifen-induced liver dysfunction may be at increased risk for granulosa cell tumors because of alterations in tamoxifen metabolism.", "tokenized_content": [2, 22119, 2024, 3861, 3, 23544, 10528, 1022, 17, 2719, 3568, 5273, 2278, 1998, 2019, 2502, 2565, 1958, 22119, 2024, 3861, 2882, 1927, 5996, 1922, 13011, 4714, 18, 3]}, "items": [{"id": "p_3051", "content": "Granulosa Cell Tumor [SEP] A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CEL", "score": 1, "type": null, "tokenized_content": [2, 22119, 2024, 2798, 3, 43, 12132, 7179, 11668, 1927, 22119, 2094, 16, 6966, 6969, 1922, 1920, 13464, 18, 1922, 1920, 4160, 2386, 16, 2176, 2278, 5531, 2673, 1920, 3375, 15765, 3]}]}
{"query": {"id": "q_3052", "content": "adenomyosis [SEP] A murine model of adenomyosis: the effects of hyperprolactinemia induced by fluoxetine hydroc", "tokenized_content": [2, 29639, 14930, 2475, 3, 43, 7135, 2322, 1927, 29639, 14930, 2475, 30, 1920, 2564, 1927, 4194, 15743, 11686, 3847, 2719, 2007, 22176, 13107, 3]}, "items": [{"id": "p_3052", "content": "Adenomyosis [SEP] The extension of endometrial tissue (ENDOMETRIUM) into the MYOMETRIUM. It usually occurs in women in their reproductive years an", "score": 1, "type": null, "tokenized_content": [2, 29639, 14930, 2475, 3, 1920, 7140, 1927, 11634, 2960, 12, 20694, 13, 2460, 1920, 25244, 2457, 18, 2176, 5394, 5110, 1922, 3089, 1922, 2310, 7986, 2739, 1925, 3]}]}
{"query": {"id": "q_3053", "content": "hyperprolactinemia [SEP] A murine model of adenomyosis: the effects of hyperprolactinemia induced by fluoxetine hydrochloride, a selective serotonin reup", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 43, 7135, 2322, 1927, 29639, 14930, 2475, 30, 1920, 2564, 1927, 4194, 15743, 11686, 3847, 2719, 2007, 22176, 16675, 16, 43, 5328, 11153, 1964, 3481, 3]}, "items": [{"id": "p_3053", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_3054", "content": "fluoxetine hydrochloride [SEP] el of adenomyosis: the effects of hyperprolactinemia induced by fluoxetine hydrochloride, a selective serotonin reuptake inhibitor, on adenomyosis induc", "tokenized_content": [2, 22176, 16675, 3, 2349, 1927, 29639, 14930, 2475, 30, 1920, 2564, 1927, 4194, 15743, 11686, 3847, 2719, 2007, 22176, 16675, 16, 43, 5328, 11153, 22957, 4106, 16, 1990, 29639, 14930, 3]}, "items": [{"id": "p_3054", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_3055", "content": "serotonin [SEP] rprolactinemia induced by fluoxetine hydrochloride, a selective serotonin reuptake inhibitor, on adenomyosis induction in Wistar albino r", "tokenized_content": [2, 11153, 3, 4822, 2226, 11686, 3847, 2719, 2007, 22176, 16675, 16, 43, 5328, 11153, 22957, 4106, 16, 1990, 29639, 14930, 2475, 4408, 1922, 15668, 28734, 60, 3]}, "items": [{"id": "p_3055", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3056", "content": "fluoxetine [SEP] OBJECTIVE: The aim of this study was to investigate whether fluoxetine given to castrated and noncastrated rats caused hyperprolactine", "tokenized_content": [2, 22176, 3, 4470, 30, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 4482, 3053, 22176, 3258, 1942, 12273, 5524, 2013, 1930, 9341, 23593, 1981, 3615, 4189, 4194, 15743, 11686, 1021, 3]}, "items": [{"id": "p_3056", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_3057", "content": "hyperprolactinemia [SEP] ther fluoxetine given to castrated and noncastrated rats caused hyperprolactinemia and its effects with respect to adenomyosis. DESIGN: Fluoxetine", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2704, 22176, 3258, 1942, 12273, 5524, 2013, 1930, 9341, 23593, 1981, 3615, 4189, 4194, 15743, 11686, 3847, 1930, 2496, 2564, 1956, 5633, 1942, 29639, 14930, 3]}, "items": [{"id": "p_3057", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_3058", "content": "adenomyosis [SEP]  rats caused hyperprolactinemia and its effects with respect to adenomyosis. DESIGN: Fluoxetine, a serotonin reuptake inhibitor, was given ", "tokenized_content": [2, 29639, 14930, 2475, 3, 3615, 4189, 4194, 15743, 11686, 3847, 1930, 2496, 2564, 1956, 5633, 1942, 29639, 14930, 2475, 18, 3036, 30, 22176, 16, 43, 11153, 22957, 4106, 16, 1982, 3]}, "items": [{"id": "p_3058", "content": "Adenomyosis [SEP] The extension of endometrial tissue (ENDOMETRIUM) into the MYOMETRIUM. It usually occurs in women in their reproductive years an", "score": 1, "type": null, "tokenized_content": [2, 29639, 14930, 2475, 3, 1920, 7140, 1927, 11634, 2960, 12, 20694, 13, 2460, 1920, 25244, 2457, 18, 2176, 5394, 5110, 1922, 3089, 1922, 2310, 7986, 2739, 1925, 3]}]}
{"query": {"id": "q_3059", "content": "Fluoxetine [SEP] lactinemia and its effects with respect to adenomyosis. DESIGN: Fluoxetine, a serotonin reuptake inhibitor, was given to Wistar Albino rat", "tokenized_content": [2, 22176, 3, 5641, 2053, 6026, 1930, 2496, 2564, 1956, 5633, 1942, 29639, 14930, 2475, 18, 3036, 30, 22176, 16, 43, 11153, 22957, 4106, 16, 1982, 3258, 1942, 15668, 28734, 3067, 3]}, "items": [{"id": "p_3059", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_3060", "content": "serotonin [SEP]  its effects with respect to adenomyosis. DESIGN: Fluoxetine, a serotonin reuptake inhibitor, was given to Wistar Albino rats for 98 days", "tokenized_content": [2, 11153, 3, 2496, 2564, 1956, 5633, 1942, 29639, 14930, 2475, 18, 3036, 30, 22176, 16, 43, 11153, 22957, 4106, 16, 1982, 3258, 1942, 15668, 28734, 3615, 1958, 5613, 3000, 3]}, "items": [{"id": "p_3060", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3061", "content": "steroids [SEP] use degeneration of myometrial cells in the presence of ovarian steroids that results in a myometrial invasion by endometrial stroma. Th", "tokenized_content": [2, 13039, 3, 2485, 9174, 1927, 25244, 2086, 2094, 1922, 1920, 2990, 1927, 6751, 13039, 1988, 2274, 1922, 43, 25244, 2086, 6254, 2007, 11634, 13511, 18, 1913, 3]}, "items": [{"id": "p_3061", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3062", "content": "hypotension [SEP] Effects of deliberate hypotension induced by labetalol with isoflurane on neuropsychological func", "tokenized_content": [2, 16453, 3, 2564, 1927, 24921, 13108, 16453, 2719, 2007, 2857, 3949, 1945, 1956, 15362, 1990, 14612, 2277, 1030, 3]}, "items": [{"id": "p_3062", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3063", "content": "labetalol [SEP] Effects of deliberate hypotension induced by labetalol with isoflurane on neuropsychological function.", "tokenized_content": [2, 2857, 3949, 1945, 3, 2564, 1927, 24921, 13108, 16453, 2719, 2007, 2857, 3949, 1945, 1956, 15362, 1990, 14612, 2347, 18, 3]}, "items": [{"id": "p_3063", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_3064", "content": "isoflurane [SEP] Effects of deliberate hypotension induced by labetalol with isoflurane on neuropsychological function.", "tokenized_content": [2, 15362, 3, 2564, 1927, 24921, 13108, 16453, 2719, 2007, 2857, 3949, 1945, 1956, 15362, 1990, 14612, 2347, 18, 3]}, "items": [{"id": "p_3064", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_3065", "content": "hypotension [SEP] The effect of deliberate hypotension on brain function measured by neuropsychological tests was stud", "tokenized_content": [2, 16453, 3, 1920, 2495, 1927, 24921, 13108, 16453, 1990, 3068, 2347, 3045, 2007, 14612, 4026, 1982, 2060, 3]}, "items": [{"id": "p_3065", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3066", "content": "labetalol [SEP] d for middle-ear surgery with deliberate hypotension induced by labetalol with isoflurane (hypotensive group). Seventeen patients without", "tokenized_content": [2, 2857, 3949, 1945, 3, 46, 1958, 5576, 17, 4352, 3782, 1956, 24921, 13108, 16453, 2719, 2007, 2857, 3949, 1945, 1956, 15362, 12, 12201, 3766, 2210, 13, 18, 22839, 2132, 2979, 3]}, "items": [{"id": "p_3066", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_3067", "content": "isoflurane [SEP] r surgery with deliberate hypotension induced by labetalol with isoflurane (hypotensive group). Seventeen patients without hypotension ser", "tokenized_content": [2, 15362, 3, 60, 3782, 1956, 24921, 13108, 16453, 2719, 2007, 2857, 3949, 1945, 1956, 15362, 12, 12201, 3766, 2210, 13, 18, 22839, 2132, 2979, 16453, 2375, 3]}, "items": [{"id": "p_3067", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_3068", "content": "hypotensive [SEP] th deliberate hypotension induced by labetalol with isoflurane (hypotensive group). Seventeen patients without hypotension served as a cont", "tokenized_content": [2, 12201, 3766, 3, 1913, 24921, 13108, 16453, 2719, 2007, 2857, 3949, 1945, 1956, 15362, 12, 12201, 3766, 2210, 13, 18, 22839, 2132, 2979, 16453, 9599, 1966, 43, 2120, 3]}, "items": [{"id": "p_3068", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3069", "content": "anxiety [SEP] it symbol), Trail-Making tests A and B, Zung tests (self-rating anxiety scale and self-rating depression scale) and two-part memory tes", "tokenized_content": [2, 5592, 3, 2176, 17530, 13, 16, 11558, 17, 5399, 4026, 43, 1930, 44, 16, 68, 3317, 4026, 12, 3543, 17, 7276, 5592, 3536, 1930, 3543, 17, 7276, 4621, 3536, 13, 3]}, "items": [{"id": "p_3069", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_3070", "content": "depression [SEP]  A and B, Zung tests (self-rating anxiety scale and self-rating depression scale) and two-part memory test battery with immediate and dela", "tokenized_content": [2, 4621, 3, 43, 1930, 44, 16, 68, 3317, 4026, 12, 3543, 17, 7276, 5592, 3536, 1930, 3543, 17, 7276, 4621, 3536, 13, 1930, 2288, 17, 3131, 4525, 2648, 14352, 1956, 3]}, "items": [{"id": "p_3070", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_3071", "content": "Bupivacaine [SEP] lder region under an interscalene brachial plexus block (IBPB). Bupivacaine 0.75% with adrenaline was given followed by a 24-hr continuous ", "tokenized_content": [2, 25473, 3, 5091, 1915, 3031, 2441, 1925, 7934, 9546, 2912, 19459, 17438, 3367, 12, 6180, 16752, 13, 18, 25473, 20, 18, 4089, 9, 1956, 10651, 2053, 1982, 3258, 3489, 2007, 3]}, "items": [{"id": "p_3071", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_3072", "content": "adrenaline [SEP] terscalene brachial plexus block (IBPB). Bupivacaine 0.75% with adrenaline was given followed by a 24-hr continuous infusion of 0.25% bupi", "tokenized_content": [2, 10651, 2053, 3, 6005, 12709, 2603, 2912, 19459, 17438, 3367, 12, 6180, 16752, 13, 18, 25473, 20, 18, 4089, 9, 1956, 10651, 2053, 1982, 3258, 3489, 2007, 43, 2686, 17, 3]}, "items": [{"id": "p_3072", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3073", "content": "bupivacaine [SEP] line was given followed by a 24-hr continuous infusion of 0.25% bupivacaine. Three audiometric threshold measurements (0.25-18 kHz) were ma", "tokenized_content": [2, 25473, 3, 2823, 1982, 3258, 3489, 2007, 43, 2686, 17, 3668, 4798, 7386, 1927, 20, 18, 2637, 9, 25473, 18, 2559, 18609, 14578, 3133, 4683, 4146, 12, 20, 18, 2637, 3]}, "items": [{"id": "p_3073", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_3074", "content": "hearing impairment [SEP] nd the third on the first day after operation. In four patients hearing impairment on the side of the block was demonstrated after operation, in t", "tokenized_content": [2, 8512, 6159, 3, 8026, 1920, 4563, 1990, 1920, 2561, 3007, 2256, 7277, 18, 1922, 3006, 2132, 8512, 6159, 1990, 1920, 4159, 1927, 1920, 3367, 1982, 3161, 2256, 7277, 16, 1922, 3]}, "items": [{"id": "p_3074", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_3075", "content": "auditory dysfunction [SEP] at 6-10 kHz on the opposite side also. IBPB may cause transient auditory dysfunction in the ipsilateral ear, possibly via an effect on sympathetic i", "tokenized_content": [2, 8401, 5273, 3, 2019, 26, 17, 2119, 12528, 1990, 1920, 8179, 4159, 2222, 18, 6180, 16752, 2278, 3936, 6809, 8401, 5273, 1922, 1920, 13014, 4352, 16, 6553, 3454, 1925, 2495, 3]}, "items": [{"id": "p_3075", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_3076", "content": "Midazolam [SEP] Midazolam compared with thiopentone as an induction agent.", "tokenized_content": [2, 23380, 3, 23380, 2452, 1956, 15331, 17125, 5405, 1021, 1966, 1925, 4408, 5899, 18, 3]}, "items": [{"id": "p_3076", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_3077", "content": "thiopentone [SEP] Midazolam compared with thiopentone as an induction agent.", "tokenized_content": [2, 15331, 17125, 5405, 1021, 3, 23380, 2452, 1956, 15331, 17125, 5405, 1021, 1966, 1925, 4408, 5899, 18, 3]}, "items": [{"id": "p_3077", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_3078", "content": "scopolamine [SEP] In patients premedicated with scopolamine + morphine (+5 mg nitrazepam the evening before surgery), the s", "tokenized_content": [2, 25392, 10173, 25157, 3, 1922, 2132, 6546, 8943, 1981, 1956, 25392, 10173, 25157, 15, 11553, 12, 15, 25, 2786, 8214, 28231, 1920, 19162, 3119, 3782, 13, 16, 1920, 61, 3]}, "items": [{"id": "p_3078", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_3079", "content": "morphine [SEP] In patients premedicated with scopolamine + morphine (+5 mg nitrazepam the evening before surgery), the sleep-induci", "tokenized_content": [2, 11553, 3, 1922, 2132, 6546, 8943, 1981, 1956, 25392, 10173, 25157, 15, 11553, 12, 15, 25, 2786, 8214, 28231, 1920, 19162, 3119, 3782, 13, 16, 1920, 5006, 17, 4320, 1033, 3]}, "items": [{"id": "p_3079", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3080", "content": "nitrazepam [SEP] In patients premedicated with scopolamine + morphine (+5 mg nitrazepam the evening before surgery), the sleep-inducing effect of midaz", "tokenized_content": [2, 8214, 28231, 3, 1922, 2132, 6546, 8943, 1981, 1956, 25392, 10173, 25157, 15, 11553, 12, 15, 25, 2786, 8214, 28231, 1920, 19162, 3119, 3782, 13, 16, 1920, 5006, 17, 7834, 3]}, "items": [{"id": "p_3080", "content": "Nitrazepam [SEP] A benzodiazepine derivative used as an anticonvulsant and hypnotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8214, 28231, 3, 43, 27266, 10533, 2251, 1966, 1925, 26572, 2031, 1930, 25810, 3153, 18, 3]}]}
{"query": {"id": "q_3081", "content": "midazolam [SEP] zepam the evening before surgery), the sleep-inducing effect of midazolam 0.15 mg/kg i.v. was clearly slower in onset than that of thiope", "tokenized_content": [2, 23380, 3, 6116, 4302, 1035, 1920, 19162, 3119, 3782, 13, 16, 1920, 5006, 17, 7834, 2495, 1927, 23380, 20, 18, 2461, 2786, 19, 3621, 51, 18, 64, 18, 1982, 5436, 3]}, "items": [{"id": "p_3081", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_3082", "content": "thiopentone [SEP] azolam 0.15 mg/kg i.v. was clearly slower in onset than that of thiopentone 4.67 mg/kg i.v. Somewhat fewer cardiovascular and local sequela", "tokenized_content": [2, 15331, 17125, 5405, 1021, 3, 27381, 10082, 20, 18, 2461, 2786, 19, 3621, 51, 18, 64, 18, 1982, 5436, 10353, 1922, 4727, 2254, 1988, 1927, 15331, 17125, 5405, 1021, 24, 3]}, "items": [{"id": "p_3082", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_3083", "content": "apnoea [SEP] local sequelae were found in the midazolam group, but, although apnoea occurred less often in the midazolam group it lasted longer. On", "tokenized_content": [2, 2100, 26447, 3, 3076, 19067, 1985, 2435, 1922, 1920, 23380, 2210, 16, 2308, 16, 2876, 2100, 26447, 4807, 2941, 3868, 1922, 1920, 23380, 2210, 2176, 16276, 4872, 18, 1990, 3]}, "items": [{"id": "p_3083", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_3084", "content": "Midazolam [SEP] idazolam and thiopentone had no apparent clinical consequences. Midazolam is a new alternative agent for induction in combination anaesth", "tokenized_content": [2, 23380, 3, 29930, 13642, 10082, 1930, 15331, 17125, 5405, 1021, 2430, 2239, 6273, 2535, 7080, 18, 23380, 1977, 43, 2814, 5012, 5899, 1958, 4408, 1922, 3921, 12023, 3]}, "items": [{"id": "p_3084", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_3085", "content": "Cardiotoxic [SEP] Cardiotoxic and possible leukemogenic effects of adriamycin in nonhuman pri", "tokenized_content": [2, 21129, 4575, 18068, 1030, 3, 21129, 4575, 18068, 1030, 1930, 3216, 22823, 3880, 2564, 1927, 25622, 7898, 1922, 25686, 17618, 3]}, "items": [{"id": "p_3085", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3086", "content": "adriamycin [SEP] Cardiotoxic and possible leukemogenic effects of adriamycin in nonhuman primates.", "tokenized_content": [2, 25622, 7898, 3, 21129, 4575, 18068, 1030, 1930, 3216, 22823, 3880, 2564, 1927, 25622, 7898, 1922, 25686, 15445, 18, 3]}, "items": [{"id": "p_3086", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3087", "content": "adriamycin [SEP] 10 monkeys (macaques) received adriamycin by monthly intravenous injections at 12 mg/m2 (1 mg/kg). 8 of t", "tokenized_content": [2, 25622, 7898, 3, 2119, 11909, 12, 18161, 13, 4004, 25622, 7898, 2007, 12036, 7307, 8775, 2019, 2369, 2786, 19, 6056, 12, 21, 2786, 19, 3621, 13, 18, 28, 1927, 62, 3]}, "items": [{"id": "p_3087", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3088", "content": "congestive heart failure [SEP] injections at 12 mg/m2 (1 mg/kg). 8 of the 10 monkeys developed congestive heart failure at an average cumulative adriamycin dose (310 mg/m2) well below", "tokenized_content": [2, 20180, 4003, 4574, 3, 8775, 2019, 2369, 2786, 19, 6056, 12, 21, 2786, 19, 3621, 13, 18, 28, 1927, 1920, 2119, 11909, 3530, 20180, 4003, 4574, 2019, 1925, 3361, 8274, 3]}, "items": [{"id": "p_3088", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3089", "content": "myocardial lesions [SEP] ed the safe upper limit (550 mg/m2) in man. Histologically, the myocardial lesions resembled those found in human anthracycline-induced cardiomyop", "tokenized_content": [2, 6497, 4518, 3, 3347, 1920, 7672, 5199, 4411, 12, 16685, 2786, 19, 6056, 13, 1922, 2323, 18, 15055, 16, 1920, 6497, 4518, 22795, 2690, 2435, 1922, 2616, 30021, 17, 2719, 3]}, "items": [{"id": "p_3089", "content": "Blister [SEP] Visible accumulations of fluid within or beneath the epidermis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2266, 7263, 3, 7816, 4858, 1036, 1927, 5466, 2651, 2014, 22419, 1920, 14512, 18, 3]}]}
{"query": {"id": "q_3090", "content": "anthracycline [SEP] ogically, the myocardial lesions resembled those found in human anthracycline-induced cardiomyopathy. 1 of the 10 monkeys developed acute mye", "tokenized_content": [2, 30021, 3, 17395, 2901, 16, 1920, 6497, 4518, 22795, 2690, 2435, 1922, 2616, 30021, 17, 2719, 14141, 18, 21, 1927, 1920, 2119, 11909, 3530, 3939, 3057, 1021, 3]}, "items": [{"id": "p_3090", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_3091", "content": "cardiomyopathy [SEP] al lesions resembled those found in human anthracycline-induced cardiomyopathy. 1 of the 10 monkeys developed acute myeloblastic leukemia afte", "tokenized_content": [2, 14141, 3, 1969, 4518, 22795, 2690, 2435, 1922, 2616, 30021, 17, 2719, 14141, 18, 21, 1927, 1920, 2119, 11909, 3530, 3939, 5707, 15076, 8111, 2221, 2057, 3]}, "items": [{"id": "p_3091", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3092", "content": "acute myeloblastic leukemia [SEP] racycline-induced cardiomyopathy. 1 of the 10 monkeys developed acute myeloblastic leukemia after receiving 324 mg/m2 of adriamycin; the 10th monkey is ali", "tokenized_content": [2, 3939, 5707, 15076, 8111, 3, 7195, 9773, 17, 2719, 14141, 18, 21, 1927, 1920, 2119, 11909, 3530, 3939, 5707, 15076, 8111, 2256, 5962, 24067, 2786, 19, 6056, 1927, 25622, 7898, 3]}, "items": [{"id": "p_3092", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_3093", "content": "leukemia [SEP] ardiomyopathy. 1 of the 10 monkeys developed acute myeloblastic leukemia after receiving 324 mg/m2 of adriamycin; the 10th monkey is ali", "tokenized_content": [2, 8111, 3, 2245, 7408, 3542, 6522, 18, 21, 1927, 1920, 2119, 11909, 3530, 3939, 5707, 15076, 8111, 2256, 5962, 24067, 2786, 19, 6056, 1927, 25622, 7898, 31, 1920, 20005, 14055, 3]}, "items": [{"id": "p_3093", "content": "Leukemia [SEP] A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukoc", "score": 1, "type": null, "tokenized_content": [2, 8111, 3, 43, 7529, 16, 6558, 2573, 1927, 1920, 2877, 17, 7402, 7393, 16, 4378, 2007, 22797, 4031, 1930, 2740, 1927, 5104, 1994, 3]}]}
{"query": {"id": "q_3094", "content": "Doxorubicin [SEP] Doxorubicin cardiomyopathy in children with left-sided Wilms tumor.", "tokenized_content": [2, 12377, 3, 12377, 14141, 1922, 3069, 1956, 3506, 17, 11175, 8534, 2800, 2798, 18, 3]}, "items": [{"id": "p_3094", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3095", "content": "cardiomyopathy [SEP] Doxorubicin cardiomyopathy in children with left-sided Wilms tumor.", "tokenized_content": [2, 14141, 3, 12377, 14141, 1922, 3069, 1956, 3506, 17, 11175, 8534, 2800, 2798, 18, 3]}, "items": [{"id": "p_3095", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3096", "content": "Wilms tumor [SEP] Doxorubicin cardiomyopathy in children with left-sided Wilms tumor.", "tokenized_content": [2, 8534, 2800, 2798, 3, 12377, 14141, 1922, 3069, 1956, 3506, 17, 11175, 8534, 2800, 2798, 18, 3]}, "items": [{"id": "p_3096", "content": "Wilms Tumor [SEP] A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epit", "score": 1, "type": null, "tokenized_content": [2, 8534, 2800, 2798, 3, 43, 6558, 5245, 2798, 16, 4189, 2007, 1920, 15734, 25834, 1927, 4604, 4402, 12, 7851, 30426, 13, 16, 9709, 12, 9709, 2094, 13, 16, 1930, 7452, 3]}]}
{"query": {"id": "q_3097", "content": "Wilms tumor [SEP] Two children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopa", "tokenized_content": [2, 8534, 2800, 2798, 3, 2288, 3069, 1956, 8534, 2800, 2798, 1927, 1920, 3506, 5245, 6090, 4010, 30021, 8291, 8228, 3]}, "items": [{"id": "p_3097", "content": "Wilms Tumor [SEP] A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epit", "score": 1, "type": null, "tokenized_content": [2, 8534, 2800, 2798, 3, 43, 6558, 5245, 2798, 16, 4189, 2007, 1920, 15734, 25834, 1927, 4604, 4402, 12, 7851, 30426, 13, 16, 9709, 12, 9709, 2094, 13, 16, 1930, 7452, 3]}]}
{"query": {"id": "q_3098", "content": "anthracycline [SEP] children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopathy after irradiation to the tumor bed and conventio", "tokenized_content": [2, 30021, 3, 3069, 1956, 8534, 2800, 2798, 1927, 1920, 3506, 5245, 6090, 4010, 30021, 14141, 2256, 7759, 1942, 1920, 2798, 7497, 1930, 10890, 1914, 1037, 3]}, "items": [{"id": "p_3098", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_3099", "content": "cardiomyopathy [SEP] Wilms tumor of the left kidney experienced severe anthracycline cardiomyopathy after irradiation to the tumor bed and conventional dosage of d", "tokenized_content": [2, 14141, 3, 8534, 2800, 2798, 1927, 1920, 3506, 5245, 6090, 4010, 30021, 14141, 2256, 7759, 1942, 1920, 2798, 7497, 1930, 5552, 9998, 1927, 46, 3]}, "items": [{"id": "p_3099", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3100", "content": "tumor [SEP] Two children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopa", "tokenized_content": [2, 2798, 3, 2288, 3069, 1956, 8534, 2800, 2798, 1927, 1920, 3506, 5245, 6090, 4010, 30021, 8291, 8228, 3]}, "items": [{"id": "p_3100", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3101", "content": "doxorubicin [SEP] y after irradiation to the tumor bed and conventional dosage of doxorubicin. The cardiomyopathy is attributed 1) to the fact that radiation", "tokenized_content": [2, 12377, 3, 67, 2256, 7759, 1942, 1920, 2798, 7497, 1930, 5552, 9998, 1927, 12377, 18, 1920, 14141, 1977, 6898, 21, 13, 1942, 1920, 2371, 1988, 5442, 3]}, "items": [{"id": "p_3101", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3102", "content": "testosterone [SEP] Promotional effects of testosterone and dietary fat on prostate carcinogenesis in genetically susce", "tokenized_content": [2, 10592, 3, 10693, 1923, 2564, 1927, 10592, 1930, 6096, 3777, 1990, 5683, 12559, 1922, 9517, 3447, 1972, 3]}, "items": [{"id": "p_3102", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_3103", "content": "carcinogenesis [SEP] Promotional effects of testosterone and dietary fat on prostate carcinogenesis in genetically susceptible rats.", "tokenized_content": [2, 12559, 3, 10693, 1923, 2564, 1927, 10592, 1930, 6096, 3777, 1990, 5683, 12559, 1922, 9517, 7819, 3615, 18, 3]}, "items": [{"id": "p_3103", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_3104", "content": "prostate adenocarcinomas [SEP] rain Wistar (LW) rats, fed vegetable diet L-485, have developed prostate adenocarcinomas spontaneously (10% incidence) at average age 34 months. Convent", "tokenized_content": [2, 5683, 19960, 3, 11433, 15668, 12, 21251, 13, 3615, 16, 5788, 17627, 3986, 54, 17, 24280, 16, 2162, 3530, 5683, 19960, 12753, 12, 2119, 9, 4332, 13, 2019, 3361, 2632, 3]}, "items": [{"id": "p_3104", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_3105", "content": "testosterone [SEP]  at average age 34 months. Conventional LW rats, implanted with testosterone at age 4 months, developed a higher incidence of prostate cance", "tokenized_content": [2, 10592, 3, 2019, 3361, 2632, 3540, 3221, 18, 5552, 21251, 3615, 16, 10978, 1956, 10592, 2019, 2632, 24, 3221, 16, 3530, 43, 2580, 4332, 1927, 5683, 2112, 1972, 3]}, "items": [{"id": "p_3105", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_3106", "content": "prostate cancer [SEP] h testosterone at age 4 months, developed a higher incidence of prostate cancer after an average interval of 14 months: 24% had developed gross", "tokenized_content": [2, 5683, 2539, 3, 50, 10592, 2019, 2632, 24, 3221, 16, 3530, 43, 2580, 4332, 1927, 5683, 2539, 2256, 1925, 3361, 4979, 1927, 2607, 3221, 30, 2686, 9, 2430, 3530, 10461, 3]}, "items": [{"id": "p_3106", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_3107", "content": "tumors [SEP] after an average interval of 14 months: 24% had developed gross tumors, and 40% when it included microscopic tumors. Preliminary resul", "tokenized_content": [2, 3861, 3, 2256, 1925, 3361, 4979, 1927, 2607, 3221, 30, 2686, 9, 2430, 3530, 10461, 3861, 16, 1930, 3040, 9, 2469, 2176, 3063, 10372, 3861, 18, 8458, 2164, 3]}, "items": [{"id": "p_3107", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3108", "content": "prostatitis [SEP] ats fed diet L-485 and treated with testosterone developed only prostatitis. Experimental designs should consider genetic susceptibility as", "tokenized_content": [2, 4876, 6219, 3, 19904, 5788, 3986, 54, 17, 24280, 1930, 2868, 1956, 10592, 3530, 2444, 4876, 6219, 18, 3599, 11861, 3066, 2782, 3299, 6461, 1966, 3]}, "items": [{"id": "p_3108", "content": "Prostatitis [SEP] Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analy", "score": 1, "type": null, "tokenized_content": [2, 4876, 6219, 3, 8946, 1927, 3769, 2094, 2460, 1920, 15214, 1927, 5683, 18, 1920, 8160, 2032, 5947, 2007, 2310, 6760, 4542, 7524, 3]}]}
{"query": {"id": "q_3109", "content": "Mitomycin C [SEP] Mitomycin C associated hemolytic uremic syndrome.", "tokenized_content": [2, 28154, 45, 3, 28154, 45, 2458, 21515, 29870, 4741, 18, 3]}, "items": [{"id": "p_3109", "content": "Mitomycin [SEP] An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS caus", "score": 1, "type": null, "tokenized_content": [2, 28154, 3, 1925, 29128, 9969, 7267, 4152, 2007, 22874, 22014, 10984, 4575, 20490, 1036, 18, 2176, 1977, 2340, 1927, 1920, 2273, 17, 2014, 5083, 17, 3183, 28912, 4820, 3092, 3]}]}
{"query": {"id": "q_3110", "content": "hemolytic uremic syndrome [SEP] Mitomycin C associated hemolytic uremic syndrome.", "tokenized_content": [2, 21515, 29870, 4741, 3, 28154, 45, 2458, 21515, 29870, 4741, 18, 3]}, "items": [{"id": "p_3110", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_3111", "content": "Mitomycin C [SEP] Mitomycin C associated Hemolytic Uremic Syndrome (HUS) is a potentially fat", "tokenized_content": [2, 28154, 45, 3, 28154, 45, 2458, 21515, 29870, 4741, 12, 14723, 13, 1977, 43, 5063, 3777, 3]}, "items": [{"id": "p_3111", "content": "Mitomycin [SEP] An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS caus", "score": 1, "type": null, "tokenized_content": [2, 28154, 3, 1925, 29128, 9969, 7267, 4152, 2007, 22874, 22014, 10984, 4575, 20490, 1036, 18, 2176, 1977, 2340, 1927, 1920, 2273, 17, 2014, 5083, 17, 3183, 28912, 4820, 3092, 3]}]}
{"query": {"id": "q_3112", "content": "Hemolytic Uremic Syndrome [SEP] Mitomycin C associated Hemolytic Uremic Syndrome (HUS) is a potentially fatal but uncommon condition that is not", "tokenized_content": [2, 21515, 29870, 4741, 3, 28154, 45, 2458, 21515, 29870, 4741, 12, 14723, 13, 1977, 43, 5063, 11990, 2308, 14403, 2625, 1988, 1977, 2084, 3]}, "items": [{"id": "p_3112", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_3113", "content": "HUS [SEP] Mitomycin C associated Hemolytic Uremic Syndrome (HUS) is a potentially fatal but uncommon condition that is not yet ", "tokenized_content": [2, 14723, 3, 28154, 45, 2458, 21515, 29870, 4741, 12, 14723, 13, 1977, 43, 5063, 11990, 2308, 14403, 2625, 1988, 1977, 2084, 4898, 3]}, "items": [{"id": "p_3113", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_3114", "content": "hemolytic anemia [SEP] t is not yet widely recognised. It consists of microangiopathic hemolytic anemia, thrombocytopenia and progressive renal failure associated with", "tokenized_content": [2, 21515, 10679, 3, 62, 1977, 2084, 4898, 5673, 19248, 18, 2176, 7543, 1927, 2703, 9506, 10982, 21515, 10679, 16, 17100, 1930, 7529, 4604, 4574, 2458, 1956, 3]}, "items": [{"id": "p_3114", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3115", "content": "thrombocytopenia [SEP] y recognised. It consists of microangiopathic hemolytic anemia, thrombocytopenia and progressive renal failure associated with mitomycin C treat", "tokenized_content": [2, 17100, 3, 67, 19248, 18, 2176, 7543, 1927, 2703, 9506, 10982, 21515, 10679, 16, 17100, 1930, 7529, 4604, 4574, 2458, 1956, 28154, 45, 2297, 3]}, "items": [{"id": "p_3115", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3116", "content": "renal failure [SEP] oangiopathic hemolytic anemia, thrombocytopenia and progressive renal failure associated with mitomycin C treatment and affects about 10% of ", "tokenized_content": [2, 4604, 4574, 3, 8965, 2029, 22788, 21494, 21515, 10679, 16, 17100, 1930, 7529, 4604, 4574, 2458, 1956, 28154, 45, 2311, 1930, 6886, 3001, 2119, 9, 1927, 3]}, "items": [{"id": "p_3116", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3117", "content": "mitomycin C [SEP]  thrombocytopenia and progressive renal failure associated with mitomycin C treatment and affects about 10% of patients treated with this a", "tokenized_content": [2, 28154, 45, 3, 17100, 1930, 7529, 4604, 4574, 2458, 1956, 28154, 45, 2311, 1930, 6886, 3001, 2119, 9, 1927, 2132, 2868, 1956, 2052, 43, 3]}, "items": [{"id": "p_3117", "content": "Mitomycin [SEP] An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS caus", "score": 1, "type": null, "tokenized_content": [2, 28154, 3, 1925, 29128, 9969, 7267, 4152, 2007, 22874, 22014, 10984, 4575, 20490, 1036, 18, 2176, 1977, 2340, 1927, 1920, 2273, 17, 2014, 5083, 17, 3183, 28912, 4820, 3092, 3]}]}
{"query": {"id": "q_3118", "content": "pulmonary edema [SEP] nt and the mortality is approximately 60% from renal failure or pulmonary edema. Renal lesions are similar to those seen in idiopathic HUS and ", "tokenized_content": [2, 5352, 10144, 3, 5891, 1930, 1920, 3885, 1977, 3993, 3276, 9, 2037, 4604, 4574, 2014, 5352, 10144, 18, 4604, 4518, 2032, 2551, 1942, 2690, 3945, 1922, 13513, 14723, 1930, 3]}, "items": [{"id": "p_3118", "content": "Pulmonary Edema [SEP] Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary ", "score": 1, "type": null, "tokenized_content": [2, 5352, 10144, 3, 9122, 4858, 1927, 21263, 18021, 5148, 1005, 5466, 1922, 1920, 3614, 16, 1925, 10331, 1927, 43, 7433, 5030, 2573, 2014, 4770, 18, 5352, 3]}]}
{"query": {"id": "q_3119", "content": "Renal lesions [SEP] ity is approximately 60% from renal failure or pulmonary edema. Renal lesions are similar to those seen in idiopathic HUS and include arterio", "tokenized_content": [2, 4604, 4518, 3, 2176, 1012, 1977, 3993, 3276, 9, 2037, 4604, 4574, 2014, 5352, 10144, 18, 4604, 4518, 2032, 2551, 1942, 2690, 3945, 1922, 13513, 14723, 1930, 3951, 12480, 1037, 3]}, "items": [{"id": "p_3119", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3120", "content": "thrombi [SEP] r to those seen in idiopathic HUS and include arteriolar fibrin thrombi, expanded subendothelial zones in glomerular capillary walls, i", "tokenized_content": [2, 5700, 1033, 3, 60, 1942, 2690, 3945, 1922, 13513, 14723, 1930, 3951, 12480, 4362, 9450, 5700, 1033, 16, 8899, 2316, 27380, 12099, 1922, 11655, 9623, 12430, 16, 51, 3]}, "items": [{"id": "p_3120", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_3121", "content": "ischemic [SEP] i, expanded subendothelial zones in glomerular capillary walls, ischemic wrinkling of glomerular basement membranes and mesangiolysis. T", "tokenized_content": [2, 7427, 3, 51, 16, 8899, 2316, 27380, 12099, 1922, 11655, 9623, 12430, 16, 7427, 30386, 3961, 1927, 11655, 16702, 5726, 1930, 23363, 11149, 4662, 18, 62, 3]}, "items": [{"id": "p_3121", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_3122", "content": "gastric adenocarcinoma [SEP] inical course and pathological findings in a 65 yr-old man with gastric adenocarcinoma who developed renal failure and thrombocytopenia while on treat", "tokenized_content": [2, 6319, 9573, 3, 1922, 2046, 4914, 1930, 6598, 3056, 1922, 43, 4459, 13031, 17, 4156, 2323, 1956, 6319, 9573, 2746, 3530, 4604, 4574, 1930, 17100, 2679, 1990, 2297, 3]}, "items": [{"id": "p_3122", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_3123", "content": "fluorouracil [SEP] Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study.", "tokenized_content": [2, 21353, 3, 4798, 15280, 11497, 5378, 2409, 21353, 3181, 30, 43, 6315, 2161, 18, 3]}, "items": [{"id": "p_3123", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_3124", "content": "cardiac toxicity [SEP] Although there have been anecdotal reports of cardiac toxicity associated with fluorouracil (5-FU) therapy, this phenomenon ha", "tokenized_content": [2, 4435, 5532, 3, 2876, 2276, 2162, 2252, 28318, 10868, 4710, 1927, 4435, 5532, 2458, 1956, 21353, 12, 25, 17, 7391, 13, 3181, 16, 2052, 7902, 2118, 3]}, "items": [{"id": "p_3124", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3125", "content": "fluorouracil [SEP] have been anecdotal reports of cardiac toxicity associated with fluorouracil (5-FU) therapy, this phenomenon has not been studied in a syste", "tokenized_content": [2, 21353, 3, 2162, 2252, 28318, 10868, 4710, 1927, 4435, 5532, 2458, 1956, 21353, 12, 25, 17, 7391, 13, 3181, 16, 2052, 7902, 2258, 2084, 2252, 3942, 1922, 43, 8055, 1021, 3]}, "items": [{"id": "p_3125", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_3126", "content": "5-FU [SEP] dotal reports of cardiac toxicity associated with fluorouracil (5-FU) therapy, this phenomenon has not been studied in a systematic ", "tokenized_content": [2, 25, 17, 7391, 3, 29186, 1024, 4710, 1927, 4435, 5532, 2458, 1956, 21353, 12, 25, 17, 7391, 13, 3181, 16, 2052, 7902, 2258, 2084, 2252, 3942, 1922, 43, 5614, 3]}, "items": [{"id": "p_3126", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_3127", "content": "tumors [SEP]  on 25 patients undergoing 5-FU infusion for treatment of solid tumors in order to assess the incidence of ischemic ST changes. Patien", "tokenized_content": [2, 3861, 3, 1990, 2637, 2132, 7258, 25, 17, 7391, 7386, 1958, 2311, 1927, 5358, 3861, 1922, 3238, 1942, 2634, 1920, 4332, 1927, 7427, 1955, 2840, 18, 2091, 1917, 3]}, "items": [{"id": "p_3127", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3128", "content": "ischemic [SEP] r treatment of solid tumors in order to assess the incidence of ischemic ST changes. Patients were monitored for 23 +/- 4 hours before 5", "tokenized_content": [2, 7427, 3, 60, 2311, 1927, 5358, 3861, 1922, 3238, 1942, 2634, 1920, 4332, 1927, 7427, 1955, 2840, 18, 2132, 1985, 7027, 1958, 3020, 15, 19, 17, 24, 3967, 3119, 25, 3]}, "items": [{"id": "p_3128", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_3129", "content": "Anginal [SEP]  before 5-FU infusion, and 98 +/- 9 hours during 5-FU infusion. Anginal episodes were rare: only one patient had angina (during 5-FU in", "tokenized_content": [2, 16961, 1024, 3, 3119, 25, 17, 7391, 7386, 16, 1930, 5613, 15, 19, 17, 29, 3967, 2409, 25, 17, 7391, 7386, 18, 16961, 1024, 9232, 1985, 5844, 30, 2444, 2340, 3]}, "items": [{"id": "p_3129", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_3130", "content": "angina [SEP] 5-FU infusion. Anginal episodes were rare: only one patient had angina (during 5-FU infusion). However, asymptomatic ST changes (great", "tokenized_content": [2, 16961, 3, 25, 17, 7391, 7386, 18, 16961, 1024, 9232, 1985, 5844, 30, 2444, 2340, 2774, 2430, 16961, 12, 2409, 25, 17, 7391, 7386, 13, 18, 2406, 16, 9978, 1955, 3]}, "items": [{"id": "p_3130", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_3131", "content": "coronary artery disease [SEP] an .01). ECG changes were more common among patients with known coronary artery disease. There were two cases of sudden death, both of which occurred a", "tokenized_content": [2, 5846, 5511, 2573, 3, 1925, 18, 3287, 13, 18, 11497, 2840, 1985, 2253, 3059, 2706, 2132, 1956, 3171, 5846, 5511, 2573, 18, 2276, 1985, 2288, 2919, 1927, 12446, 3539, 16, 3]}, "items": [{"id": "p_3131", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_3132", "content": "sudden death [SEP] nts with known coronary artery disease. There were two cases of sudden death, both of which occurred at the end of the chemotherapy course. ", "tokenized_content": [2, 12446, 3539, 3, 17969, 1956, 3171, 5846, 5511, 2573, 18, 2276, 1985, 2288, 2919, 1927, 12446, 3539, 16, 2321, 1927, 2154, 4807, 2019, 1920, 2482, 1927, 1920, 5318, 4914, 18, 3]}, "items": [{"id": "p_3132", "content": "Death, Sudden [SEP] The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiov", "score": 1, "type": null, "tokenized_content": [2, 3539, 16, 12446, 3, 1920, 20135, 10975, 1927, 2136, 8970, 23792, 4088, 16, 16687, 2007, 1920, 11047, 3257, 1927, 2698, 6329, 16, 5481, 16, 1930, 21129, 1020, 3]}]}
{"query": {"id": "q_3133", "content": "ischemia [SEP] gnificant increase in silent ST segment deviation suggestive of ischemia, particularly among patients with coronary artery disease. The ", "tokenized_content": [2, 7716, 3, 9005, 2077, 2031, 2760, 1922, 15381, 1955, 5367, 6015, 12855, 1927, 7716, 16, 4443, 2706, 2132, 1956, 5846, 5511, 2573, 18, 1920, 3]}, "items": [{"id": "p_3133", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_3134", "content": "anuria [SEP] Lethal anuria complicating high dose ifosfamide chemotherapy in a breast canc", "tokenized_content": [2, 1925, 8754, 3, 10470, 1925, 8754, 6581, 6102, 2104, 2149, 3253, 2647, 1951, 6016, 16408, 1021, 5318, 1922, 43, 3739, 2112, 1030, 3]}, "items": [{"id": "p_3134", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_3135", "content": "ifosfamide [SEP] Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal ", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 10470, 1925, 8754, 6581, 6102, 2104, 2149, 3253, 2647, 1951, 6016, 16408, 1021, 5318, 1922, 43, 3739, 2539, 2774, 1956, 1925, 5761, 4604, 3]}, "items": [{"id": "p_3135", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3136", "content": "breast cancer [SEP] thal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.", "tokenized_content": [2, 3739, 2539, 3, 15717, 1925, 8754, 6581, 6102, 2104, 2149, 3253, 2647, 1951, 6016, 16408, 1021, 5318, 1922, 43, 3739, 2539, 2774, 1956, 1925, 5761, 4604, 2347, 18, 3]}, "items": [{"id": "p_3136", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3137", "content": "impaired renal function [SEP] dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.", "tokenized_content": [2, 5761, 4604, 2347, 3, 3253, 2647, 1951, 6016, 16408, 1021, 5318, 1922, 43, 3739, 2539, 2774, 1956, 1925, 5761, 4604, 2347, 18, 3]}, "items": [{"id": "p_3137", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3138", "content": "breast cancer [SEP] A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible l", "tokenized_content": [2, 3739, 2539, 3, 43, 14063, 17, 2476, 17, 4156, 10440, 1956, 5570, 3739, 2539, 16, 3024, 2868, 1956, 9284, 16, 3530, 1925, 14104, 54, 3]}, "items": [{"id": "p_3138", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3139", "content": "cisplatin [SEP] -old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, th", "tokenized_content": [2, 9284, 3, 17, 4156, 10440, 1956, 5570, 3739, 2539, 16, 3024, 2868, 1956, 9284, 16, 3530, 1925, 14104, 10470, 4604, 4574, 1956, 1925, 8754, 16, 1913, 3]}, "items": [{"id": "p_3139", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3140", "content": "renal failure [SEP] iously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide. Postrenal f", "tokenized_content": [2, 4604, 4574, 3, 21509, 1957, 1954, 2868, 1956, 9284, 16, 3530, 1925, 14104, 10470, 4604, 4574, 1956, 1925, 8754, 16, 1920, 3007, 2256, 25, 49, 19, 6056, 14840, 2647, 1951, 3]}, "items": [{"id": "p_3140", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3141", "content": "anuria [SEP]  cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide. Postrenal failure was e", "tokenized_content": [2, 1925, 8754, 3, 9284, 16, 3530, 1925, 14104, 10470, 4604, 4574, 1956, 1925, 8754, 16, 1920, 3007, 2256, 25, 49, 19, 6056, 14840, 2647, 1951, 6016, 16408, 1021, 18, 2753, 3]}, "items": [{"id": "p_3141", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_3142", "content": "ifosfamide [SEP] le lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide. Postrenal failure was excluded by echography. A prerenal compo", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2071, 10470, 4604, 4574, 1956, 1925, 8754, 16, 1920, 3007, 2256, 25, 49, 19, 6056, 14840, 2647, 1951, 6016, 16408, 1021, 18, 2753, 2825, 3]}, "items": [{"id": "p_3142", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3143", "content": "Postrenal failure [SEP] nal failure with anuria, the day after 5 g/m2 bolus ifosfamide. Postrenal failure was excluded by echography. A prerenal component could have con", "tokenized_content": [2, 2753, 2825, 1923, 4574, 3, 13120, 4574, 1956, 1925, 8754, 16, 1920, 3007, 2256, 25, 49, 19, 6056, 14840, 2647, 1951, 6016, 16408, 1021, 18, 2753, 2825, 1923, 4574, 1982, 3]}, "items": [{"id": "p_3143", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3144", "content": "hypotension [SEP]  could have contributed to renal failure because of a transient hypotension, due to an increasing ascitis, occurring just before anuria. Ho", "tokenized_content": [2, 16453, 3, 2578, 2162, 6505, 1942, 4604, 4574, 2882, 1927, 43, 6809, 16453, 16, 2810, 1942, 1925, 3605, 7249, 3678, 16, 6966, 6244, 3119, 1925, 8754, 18, 6673, 3]}, "items": [{"id": "p_3144", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3145", "content": "Ifosfamide [SEP] n of the hemodynamic parameters did not improve renal function. Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies. We", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 56, 1927, 1920, 12173, 3673, 2811, 2084, 3326, 4604, 2347, 18, 2647, 1951, 6016, 16408, 1021, 1977, 43, 3171, 22994, 10605, 2838, 1956, 3161, 3]}, "items": [{"id": "p_3145", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3146", "content": "nephrotoxic [SEP] arameters did not improve renal function. Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies. We strongly suspect that ", "tokenized_content": [2, 22994, 10605, 3, 20289, 14578, 2045, 2811, 2084, 3326, 4604, 2347, 18, 2647, 1951, 6016, 16408, 1021, 1977, 43, 3171, 22994, 10605, 2838, 1956, 3161, 25860, 16038, 18, 2038, 4937, 3]}, "items": [{"id": "p_3146", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3147", "content": "tubulopathies [SEP] ction. Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies. We strongly suspect that this lethal anuria was mainly due to ", "tokenized_content": [2, 25860, 16038, 3, 3369, 2001, 18, 2647, 1951, 6016, 16408, 1021, 1977, 43, 3171, 22994, 10605, 2838, 1956, 3161, 25860, 16038, 18, 2038, 4937, 21339, 1988, 2052, 10470, 1925, 8754, 3]}, "items": [{"id": "p_3147", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3148", "content": "vein thrombosis [SEP] Central vein thrombosis and topical dipivalyl epinephrine.", "tokenized_content": [2, 7920, 11354, 3, 4101, 7920, 11354, 1930, 12259, 9137, 2987, 2199, 19280, 18, 3]}, "items": [{"id": "p_3148", "content": "Venous Thrombosis [SEP] The formation or presence of a blood clot (THROMBUS) within a vein.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 11354, 3, 1920, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 2651, 43, 7920, 18, 3]}]}
{"query": {"id": "q_3149", "content": "dipivalyl epinephrine [SEP] Central vein thrombosis and topical dipivalyl epinephrine.", "tokenized_content": [2, 9137, 2987, 2199, 19280, 3, 4101, 7920, 11354, 1930, 12259, 9137, 2987, 2199, 19280, 18, 3]}, "items": [{"id": "p_3149", "content": "dipivefrin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9137, 2320, 7134, 1921, 3, 3]}]}
{"query": {"id": "q_3150", "content": "vein thrombosis [SEP] A report is given on an 83-year-old female who acquired central vein thrombosis in her seeing eye one day after having started topical medicati", "tokenized_content": [2, 7920, 11354, 3, 43, 3809, 1977, 3258, 1990, 1925, 5893, 17, 2476, 17, 4156, 4232, 2746, 5815, 4101, 7920, 11354, 1922, 3656, 23124, 5723, 2340, 3007, 2256, 4537, 8074, 12259, 3]}, "items": [{"id": "p_3150", "content": "Venous Thrombosis [SEP] The formation or presence of a blood clot (THROMBUS) within a vein.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 11354, 3, 1920, 3337, 2014, 2990, 1927, 43, 2877, 15053, 12, 16705, 13, 2651, 43, 7920, 18, 3]}]}
{"query": {"id": "q_3151", "content": "dipivalyl epinephrine [SEP] seeing eye one day after having started topical medication with dipivalyl epinephrine for advanced glaucoma discovered in the other eye. From present", "tokenized_content": [2, 9137, 2987, 2199, 19280, 3, 23124, 5723, 2340, 3007, 2256, 4537, 8074, 12259, 6093, 1956, 9137, 2987, 2199, 19280, 1958, 5570, 12106, 8117, 1922, 1920, 2303, 5723, 18, 2037, 2481, 3]}, "items": [{"id": "p_3151", "content": "dipivefrin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9137, 2320, 7134, 1921, 3, 3]}]}
{"query": {"id": "q_3152", "content": "glaucoma [SEP] rted topical medication with dipivalyl epinephrine for advanced glaucoma discovered in the other eye. From present knowledge about the e", "tokenized_content": [2, 12106, 3, 4341, 1919, 12259, 6093, 1956, 9137, 2987, 2199, 19280, 1958, 5570, 12106, 8117, 1922, 1920, 2303, 5723, 18, 2037, 2481, 4163, 3001, 1920, 47, 3]}, "items": [{"id": "p_3152", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_3153", "content": "bendrofluazide [SEP] Amelioration of bendrofluazide-induced hypokalemia by timolol.", "tokenized_content": [2, 20672, 28716, 5277, 29895, 3, 11963, 1943, 1927, 20672, 28716, 5277, 29895, 17, 2719, 14395, 7640, 1952, 6026, 2007, 2267, 23646, 18, 3]}, "items": [{"id": "p_3153", "content": "Bendroflumethiazide [SEP] A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial", "score": 1, "type": null, "tokenized_content": [2, 20672, 28716, 5277, 23568, 7736, 2261, 3, 43, 27225, 2261, 26829, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 14369, 30354, 2261, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 11444, 3]}]}
{"query": {"id": "q_3154", "content": "hypokalemia [SEP] Amelioration of bendrofluazide-induced hypokalemia by timolol.", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 11963, 1943, 1927, 20672, 28716, 5277, 29895, 17, 2719, 14395, 7640, 1952, 6026, 2007, 2267, 23646, 18, 3]}, "items": [{"id": "p_3154", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_3155", "content": "timolol [SEP] Amelioration of bendrofluazide-induced hypokalemia by timolol.", "tokenized_content": [2, 2267, 23646, 3, 11963, 1943, 1927, 20672, 28716, 5277, 29895, 17, 2719, 14395, 7640, 1952, 6026, 2007, 2267, 23646, 18, 3]}, "items": [{"id": "p_3155", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_3156", "content": "timolol [SEP] The beta adrenergic blocking drug, timolol, tended to correct the hypokalemia of short-term bendrofluazide", "tokenized_content": [2, 2267, 23646, 3, 1920, 4666, 13672, 7472, 2838, 16, 2267, 23646, 16, 10587, 1942, 5550, 1920, 14395, 7640, 1952, 6026, 1927, 3662, 17, 2576, 20672, 28716, 5277, 29895, 3]}, "items": [{"id": "p_3156", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_3157", "content": "hypokalemia [SEP] e beta adrenergic blocking drug, timolol, tended to correct the hypokalemia of short-term bendrofluazide treatment in 6 healthy male subjec", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 47, 4666, 13672, 7472, 2838, 16, 2267, 23646, 16, 10587, 1942, 5550, 1920, 14395, 7640, 1952, 6026, 1927, 3662, 17, 2576, 20672, 28716, 5277, 29895, 3]}, "items": [{"id": "p_3157", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_3158", "content": "bendrofluazide [SEP]  drug, timolol, tended to correct the hypokalemia of short-term bendrofluazide treatment in 6 healthy male subjects and although the effect wa", "tokenized_content": [2, 20672, 28716, 5277, 29895, 3, 2838, 16, 2267, 23646, 16, 10587, 1942, 5550, 1920, 14395, 7640, 1952, 6026, 1927, 3662, 17, 2576, 20672, 28716, 5277, 29895, 2311, 1922, 26, 4097, 3]}, "items": [{"id": "p_3158", "content": "Bendroflumethiazide [SEP] A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial", "score": 1, "type": null, "tokenized_content": [2, 20672, 28716, 5277, 23568, 7736, 2261, 3, 43, 27225, 2261, 26829, 1956, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 14369, 30354, 2261, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 11444, 3]}]}
{"query": {"id": "q_3159", "content": "Timolol [SEP]  subjects and although the effect was small it was significant. Timolol also reduced the rise in plasma aldosterone and urine potassium", "tokenized_content": [2, 2267, 23646, 3, 3297, 1930, 2876, 1920, 2495, 1982, 2858, 2176, 1982, 2228, 18, 2267, 23646, 2222, 3028, 1920, 7164, 1922, 3582, 16944, 1930, 6960, 9057, 3]}, "items": [{"id": "p_3159", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_3160", "content": "aldosterone [SEP] all it was significant. Timolol also reduced the rise in plasma aldosterone and urine potassium excretion following bendrofluazide and incr", "tokenized_content": [2, 16944, 3, 2136, 2176, 1982, 2228, 18, 2267, 23646, 2222, 3028, 1920, 7164, 1922, 3582, 16944, 1930, 6960, 9057, 11093, 2894, 20672, 28716, 5277, 29895, 1930, 2043, 1005, 3]}, "items": [{"id": "p_3160", "content": "Aldosterone [SEP] A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodiu", "score": 1, "type": null, "tokenized_content": [2, 16944, 3, 43, 6365, 8366, 2007, 1920, 10651, 4997, 1988, 7014, 15428, 1930, 3224, 6766, 2007, 3605, 1920, 4604, 7521, 1927, 4546, 1033, 1032, 3]}]}
{"query": {"id": "q_3161", "content": "potassium [SEP] . Timolol also reduced the rise in plasma aldosterone and urine potassium excretion following bendrofluazide and increased the urine sodi", "tokenized_content": [2, 9057, 3, 18, 2267, 23646, 2222, 3028, 1920, 7164, 1922, 3582, 16944, 1930, 6960, 9057, 11093, 2894, 20672, 28716, 5277, 29895, 1930, 2502, 1920, 6960, 4546, 1033, 3]}, "items": [{"id": "p_3161", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_3162", "content": "sodium [SEP] sium excretion following bendrofluazide and increased the urine sodium/potassium ratio. There was no evidence of a shift of potassium ", "tokenized_content": [2, 5227, 3, 5998, 1989, 11093, 2894, 20672, 28716, 5277, 29895, 1930, 2502, 1920, 6960, 5227, 19, 9057, 3400, 18, 2276, 1982, 2239, 3095, 1927, 43, 5950, 1927, 9057, 3]}, "items": [{"id": "p_3162", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3163", "content": "risperidone [SEP] A cross-sectional evaluation of the effect of risperidone and selective serotonin reuptake inhibitors on bone mineral den", "tokenized_content": [2, 26991, 3, 43, 3567, 17, 7360, 4391, 1927, 1920, 2495, 1927, 26991, 1930, 5328, 11153, 22957, 4472, 1990, 3622, 8463, 4533, 3]}, "items": [{"id": "p_3163", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3164", "content": "serotonin [SEP] sectional evaluation of the effect of risperidone and selective serotonin reuptake inhibitors on bone mineral density in boys.", "tokenized_content": [2, 11153, 3, 7360, 4391, 1927, 1920, 2495, 1927, 26991, 1930, 5328, 11153, 22957, 4472, 1990, 3622, 8463, 3824, 1922, 10294, 18, 3]}, "items": [{"id": "p_3164", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3165", "content": "risperidone [SEP] : The aim of the present study was to investigate the effect of risperidone-induced hyperprolactinemia on trabecular bone mineral density (", "tokenized_content": [2, 26991, 3, 30, 1920, 3774, 1927, 1920, 2481, 2161, 1982, 1942, 4482, 1920, 2495, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1990, 15855, 3622, 8463, 3824, 12, 3]}, "items": [{"id": "p_3165", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3166", "content": "hyperprolactinemia [SEP] sent study was to investigate the effect of risperidone-induced hyperprolactinemia on trabecular bone mineral density (BMD) in children and adoles", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 8437, 2161, 1982, 1942, 4482, 1920, 2495, 1927, 26991, 17, 2719, 4194, 15743, 11686, 3847, 1990, 15855, 3622, 8463, 3824, 12, 9911, 13, 1922, 3069, 3]}, "items": [{"id": "p_3166", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_3167", "content": "Hyperprolactinemia [SEP]  was estimated using dual-energy x-ray absorptiometry. RESULTS: Hyperprolactinemia was present in 49% of 83 boys (n = 41) treated with risperidone", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 1982, 4185, 2193, 7064, 17, 3844, 66, 17, 6451, 30507, 18, 2274, 30, 4194, 15743, 11686, 3847, 1982, 2481, 1922, 4343, 9, 1927, 5893, 10294, 3]}, "items": [{"id": "p_3167", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_3168", "content": "testosterone [SEP] n = 41) treated with risperidone for a mean of 2.9 years. Serum testosterone concentration increased with pubertal status but was not affect", "tokenized_content": [2, 10592, 3, 56, 33, 4353, 13, 2868, 1956, 26991, 1958, 43, 2667, 1927, 22, 18, 29, 2739, 18, 3256, 10592, 3110, 2502, 1956, 20475, 3642, 2308, 1982, 2084, 4081, 3]}, "items": [{"id": "p_3168", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_3169", "content": "serotonin [SEP] for relevant covariates, we also found treatment with selective serotonin reuptake inhibitors (SSRIs) to be associated with lower trabecu", "tokenized_content": [2, 11153, 3, 1958, 4494, 9191, 16, 2038, 2222, 2435, 2311, 1956, 5328, 11153, 22957, 4472, 12, 29395, 13, 1942, 1998, 2458, 1956, 2826, 13365, 1032, 3]}, "items": [{"id": "p_3169", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3170", "content": "fractures [SEP] was restricted to non-Hispanic white patients. Of 13 documented fractures, 3 occurred after risperidone and SSRIs were started, and none ", "tokenized_content": [2, 9018, 3, 1982, 6715, 1942, 2447, 17, 10542, 4511, 2132, 18, 1927, 2590, 6974, 9018, 16, 23, 4807, 2256, 26991, 1930, 29395, 1985, 8074, 16, 1930, 6046, 3]}, "items": [{"id": "p_3170", "content": "Fractures, Bone [SEP] Breaks in bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3622, 3, 13065, 1922, 14153, 18, 3]}]}
{"query": {"id": "q_3171", "content": "Seizures [SEP] Seizures associated with levofloxacin: case presentation and literature ", "tokenized_content": [2, 10060, 3, 10060, 2458, 1956, 30129, 14217, 30, 3087, 6544, 1930, 4431, 3]}, "items": [{"id": "p_3171", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3172", "content": "levofloxacin [SEP] Seizures associated with levofloxacin: case presentation and literature review.", "tokenized_content": [2, 30129, 14217, 3, 10060, 2458, 1956, 30129, 14217, 30, 3087, 6544, 1930, 4431, 3043, 18, 3]}, "items": [{"id": "p_3172", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_3173", "content": "seizures [SEP] PURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to dis", "tokenized_content": [2, 10060, 3, 5120, 30, 2038, 2481, 43, 3087, 1927, 43, 2774, 2746, 3530, 10060, 17002, 2256, 12410, 2311, 1956, 30129, 14217, 1930, 1942, 2054, 3]}, "items": [{"id": "p_3173", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3174", "content": "levofloxacin [SEP]  who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to ", "tokenized_content": [2, 30129, 14217, 3, 2746, 3530, 10060, 17002, 2256, 12410, 2311, 1956, 30129, 14217, 1930, 1942, 3891, 1920, 2889, 2838, 17, 2838, 3719, 2712, 1942, 3]}, "items": [{"id": "p_3174", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_3175", "content": "lithium [SEP] Mice lacking mPGES-1 are resistant to lithium-induced polyuria.", "tokenized_content": [2, 14330, 3, 2518, 7046, 5438, 2286, 17, 21, 2032, 4910, 1942, 14330, 17, 2719, 4286, 8754, 18, 3]}, "items": [{"id": "p_3175", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_3176", "content": "polyuria [SEP] Mice lacking mPGES-1 are resistant to lithium-induced polyuria.", "tokenized_content": [2, 4286, 8754, 3, 2518, 7046, 5438, 2286, 17, 21, 2032, 4910, 1942, 14330, 17, 2719, 4286, 8754, 18, 3]}, "items": [{"id": "p_3176", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_3177", "content": "lithium [SEP] Cyclooxygenase-2 activity is required for the development of lithium-induced polyuria. However, the involvement of a specific, termi", "tokenized_content": [2, 14330, 3, 21271, 17, 22, 2455, 1977, 3414, 1958, 1920, 2740, 1927, 14330, 17, 2719, 4286, 8754, 18, 2406, 16, 1920, 5668, 1927, 43, 2487, 16, 2576, 1033, 3]}, "items": [{"id": "p_3177", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_3178", "content": "polyuria [SEP] e-2 activity is required for the development of lithium-induced polyuria. However, the involvement of a specific, terminal prostaglandin", "tokenized_content": [2, 4286, 8754, 3, 47, 17, 22, 2455, 1977, 3414, 1958, 1920, 2740, 1927, 14330, 17, 2719, 4286, 8754, 18, 2406, 16, 1920, 5668, 1927, 43, 2487, 16, 4262, 15900, 3]}, "items": [{"id": "p_3178", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_3179", "content": "prostaglandin [SEP] uced polyuria. However, the involvement of a specific, terminal prostaglandin (PG) isomerase has not been evaluated. The present study was un", "tokenized_content": [2, 15900, 3, 8577, 1919, 4286, 8754, 18, 2406, 16, 1920, 5668, 1927, 43, 2487, 16, 4262, 15900, 12, 5306, 13, 25510, 2258, 2084, 2252, 3747, 18, 1920, 2481, 2161, 1982, 3]}, "items": [{"id": "p_3179", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_3180", "content": "PG [SEP] However, the involvement of a specific, terminal prostaglandin (PG) isomerase has not been evaluated. The present study was undert", "tokenized_content": [2, 5306, 3, 2406, 16, 1920, 5668, 1927, 43, 2487, 16, 4262, 15900, 12, 5306, 13, 25510, 2258, 2084, 2252, 3747, 18, 1920, 2481, 2161, 1982, 9904, 3]}, "items": [{"id": "p_3180", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_3181", "content": "prostaglandin E [SEP] assess lithium-induced polyuria in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol.kg(", "tokenized_content": [2, 15900, 47, 3, 2634, 14330, 17, 2719, 4286, 8754, 1922, 2518, 5778, 1922, 22133, 15900, 47, 8921, 17, 21, 12, 5438, 2286, 17, 21, 13, 18, 43, 22, 17, 11939, 3]}, "items": [{"id": "p_3181", "content": "Prostaglandins E [SEP] (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-", "score": 1, "type": null, "tokenized_content": [2, 25674, 47, 3, 12, 2513, 4595, 16, 2590, 1021, 16, 2461, 1036, 13, 17, 2513, 16, 2461, 17, 20684, 17, 29, 17, 18588, 2216, 2156, 17, 2590, 17, 2066, 17, 21, 17, 25166, 1030, 2687, 12, 11435, 12, 21, 13, 13, 31, 12, 25, 1011, 16, 2513, 4595, 16, 2590, 1021, 16, 2461, 1036, 13, 17, 2513, 16, 2461, 17, 20684, 17, 29, 17, 18588, 2216, 2156, 1019, 17, 25, 16, 2590, 17, 3]}]}
{"query": {"id": "q_3182", "content": "LiCl [SEP]  prostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol.kg(-1).day(-1) ip) in mPGES-1 +/+ mice led to a marked ", "tokenized_content": [2, 27347, 3, 15900, 47, 8921, 17, 21, 12, 5438, 2286, 17, 21, 13, 18, 43, 22, 17, 11939, 4183, 1927, 27347, 12, 24, 6397, 18, 3621, 12, 17, 21, 13, 3]}, "items": [{"id": "p_3182", "content": "Lithium Chloride [SEP] A salt of lithium that has been used experimentally as an immunomodulator.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14330, 9140, 3, 43, 7012, 1927, 14330, 1988, 2258, 2252, 2251, 9568, 1966, 1925, 15345, 13505, 18, 3]}]}
{"query": {"id": "q_3183", "content": "PGE(2) [SEP] h elevated renal mPGES-1 protein expression and increased urine PGE(2) excretion. In contrast, mPGES-1 -/- mice were largely resistant", "tokenized_content": [2, 11435, 12, 22, 13, 3, 50, 4664, 4604, 5438, 2286, 17, 21, 2213, 2294, 1930, 2502, 6960, 11435, 12, 22, 13, 11093, 18, 1922, 3320, 16, 5438, 2286, 17, 21, 3]}, "items": [{"id": "p_3183", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_3184", "content": "Na [SEP] ot in the cortex. Similarly, the total protein abundance of the Na-K-2Cl cotransporter (NKCC2) in the medulla but not in the corte", "tokenized_content": [2, 4049, 3, 7608, 1922, 1920, 4997, 18, 4852, 16, 1920, 2698, 2213, 6232, 1927, 1920, 4049, 17, 53, 17, 6921, 1024, 14817, 24095, 12, 5916, 24106, 13, 1922, 1920, 18755, 3]}, "items": [{"id": "p_3184", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3185", "content": "K [SEP] in the cortex. Similarly, the total protein abundance of the Na-K-2Cl cotransporter (NKCC2) in the medulla but not in the cortex ", "tokenized_content": [2, 53, 3, 1922, 1920, 4997, 18, 4852, 16, 1920, 2698, 2213, 6232, 1927, 1920, 4049, 17, 53, 17, 6921, 1024, 14817, 24095, 12, 5916, 24106, 13, 1922, 1920, 18755, 2308, 3]}, "items": [{"id": "p_3185", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_3186", "content": "Cl [SEP] rostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol.kg(-1).day(-1) ip) in mPGES-1 +/+ mice led to a marked ", "tokenized_content": [2, 2111, 3, 29539, 13217, 1921, 47, 8921, 17, 21, 12, 5438, 2286, 17, 21, 13, 18, 43, 22, 17, 11939, 4183, 1927, 27347, 12, 24, 6397, 18, 3621, 12, 17, 3]}, "items": [{"id": "p_3186", "content": "Chlorine [SEP] A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 1", "score": 1, "type": null, "tokenized_content": [2, 25732, 3, 43, 4524, 2471, 17, 7463, 16, 24149, 3264, 4422, 1988, 1977, 43, 7210, 1927, 1920, 24778, 3416, 1927, 5362, 18, 2176, 2258, 1920, 11241, 17530, 2111, 16, 11241, 2529, 21, 3]}]}
{"query": {"id": "q_3187", "content": "chondroitin sulfate [SEP] d sensitive microplate method for the detection of oversulfated chondroitin sulfate in heparin products.", "tokenized_content": [2, 26437, 8767, 3, 46, 4532, 16444, 2417, 1958, 1920, 3805, 1927, 17774, 4042, 1981, 26437, 8767, 1922, 9962, 4461, 18, 3]}, "items": [{"id": "p_3187", "content": "Chondroitin Sulfates [SEP] Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfat", "score": 1, "type": null, "tokenized_content": [2, 26437, 8767, 1036, 3, 8383, 1927, 26437, 2154, 2162, 43, 8767, 11804, 9603, 2828, 1942, 1920, 9479, 17454, 11804, 1927, 26437, 18, 26437, 5141, 1926, 3]}]}
{"query": {"id": "q_3188", "content": "heparin [SEP] method for the detection of oversulfated chondroitin sulfate in heparin products.", "tokenized_content": [2, 9962, 3, 2417, 1958, 1920, 3805, 1927, 17774, 4042, 1981, 26437, 8767, 1922, 9962, 4461, 18, 3]}, "items": [{"id": "p_3188", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_3189", "content": "Heparin [SEP] Heparin is a commonly implemented anticoagulant used to treat criticall", "tokenized_content": [2, 9962, 3, 9962, 1977, 43, 5384, 7397, 18509, 2251, 1942, 2297, 4140, 1024, 3]}, "items": [{"id": "p_3189", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_3190", "content": "heparin [SEP] itically ill patients. Recently, a number of commercial lots of heparin products were found to be contaminated with an oversulfated cho", "tokenized_content": [2, 9962, 3, 2176, 2901, 3652, 2132, 18, 3998, 16, 43, 2529, 1927, 7357, 29110, 1927, 9962, 4461, 1985, 2435, 1942, 1998, 12882, 1956, 1925, 17774, 4042, 1981, 4551, 3]}, "items": [{"id": "p_3190", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_3191", "content": "chondroitin sulfate [SEP] rin products were found to be contaminated with an oversulfated chondroitin sulfate (OSCS) derivative that could elicit a hypotensive response in p", "tokenized_content": [2, 26437, 8767, 3, 25699, 4461, 1985, 2435, 1942, 1998, 12882, 1956, 1925, 17774, 4042, 1981, 26437, 8767, 12, 7579, 1036, 13, 10533, 1988, 2578, 12095, 43, 12201, 3766, 2644, 1922, 3]}, "items": [{"id": "p_3191", "content": "Chondroitin Sulfates [SEP] Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfat", "score": 1, "type": null, "tokenized_content": [2, 26437, 8767, 1036, 3, 8383, 1927, 26437, 2154, 2162, 43, 8767, 11804, 9603, 2828, 1942, 1920, 9479, 17454, 11804, 1927, 26437, 18, 26437, 5141, 1926, 3]}]}
{"query": {"id": "q_3192", "content": "hypotensive [SEP] fated chondroitin sulfate (OSCS) derivative that could elicit a hypotensive response in pigs following a single high-dose infusion. Using b", "tokenized_content": [2, 12201, 3766, 3, 11211, 1007, 26437, 8767, 12, 7579, 1036, 13, 10533, 1988, 2578, 12095, 43, 12201, 3766, 2644, 1922, 9586, 2894, 43, 2957, 2149, 17, 3253, 7386, 18, 2193, 3]}, "items": [{"id": "p_3192", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3193", "content": "hypotension [SEP] ced derivative, we showed that the OSCS produces dose-dependent hypotension in pigs. The no observed effect level (NOEL) for this contamina", "tokenized_content": [2, 16453, 3, 19424, 10533, 16, 2038, 2594, 1988, 1920, 7579, 1036, 9300, 3253, 17, 3100, 16453, 1922, 9586, 18, 1920, 2239, 2528, 2495, 2237, 12, 29376, 1024, 13, 1958, 2052, 3]}, "items": [{"id": "p_3193", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3194", "content": "Doxorubicin [SEP] Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuate", "tokenized_content": [2, 12377, 3, 12377, 14141, 17, 2719, 4531, 1930, 4091, 2032, 15500, 3]}, "items": [{"id": "p_3194", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3195", "content": "cardiomyopathy [SEP] Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene delet", "tokenized_content": [2, 14141, 3, 12377, 14141, 17, 2719, 4531, 1930, 4091, 2032, 8060, 2007, 2359, 4897, 1031, 3]}, "items": [{"id": "p_3195", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3196", "content": "inflammation [SEP] Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 r", "tokenized_content": [2, 4531, 3, 12377, 14141, 17, 2719, 4531, 1930, 4091, 2032, 8060, 2007, 2359, 5541, 1927, 1920, 3498, 1921, 10360, 60, 3]}, "items": [{"id": "p_3196", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_3197", "content": "anthracycline [SEP] Clinical use of the anthracycline doxorubicin (DOX) is limited by its cardiotoxic effects, which ", "tokenized_content": [2, 30021, 3, 2535, 2485, 1927, 1920, 30021, 12377, 12, 7169, 13, 1977, 3892, 2007, 2496, 21129, 4575, 18068, 1030, 2564, 16, 2154, 3]}, "items": [{"id": "p_3197", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_3198", "content": "doxorubicin [SEP] Clinical use of the anthracycline doxorubicin (DOX) is limited by its cardiotoxic effects, which are attribut", "tokenized_content": [2, 12377, 3, 2535, 2485, 1927, 1920, 30021, 12377, 12, 7169, 13, 1977, 3892, 2007, 2496, 21129, 4575, 18068, 1030, 2564, 16, 2154, 2032, 7503, 1984, 3]}, "items": [{"id": "p_3198", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3199", "content": "DOX [SEP] Clinical use of the anthracycline doxorubicin (DOX) is limited by its cardiotoxic effects, which are attributed to", "tokenized_content": [2, 7169, 3, 2535, 2485, 1927, 1920, 30021, 12377, 12, 7169, 13, 1977, 3892, 2007, 2496, 21129, 4575, 18068, 1030, 2564, 16, 2154, 2032, 6898, 1942, 3]}, "items": [{"id": "p_3199", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3200", "content": "cardiotoxic [SEP] al use of the anthracycline doxorubicin (DOX) is limited by its cardiotoxic effects, which are attributed to the induction of apoptosis. To", "tokenized_content": [2, 21129, 4575, 18068, 1030, 3, 1969, 2485, 1927, 1920, 30021, 12377, 12, 7169, 13, 1977, 3892, 2007, 2496, 21129, 4575, 18068, 1030, 2564, 16, 2154, 2032, 6898, 1942, 1920, 4408, 3]}, "items": [{"id": "p_3200", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3201", "content": "cardiomyopathy [SEP] le of the kinin B1 receptor (B1R) during the development of DOX cardiomyopathy, we studied B1R knockout mice (B1R(-/-)) by investigating cardi", "tokenized_content": [2, 14141, 3, 2071, 1927, 1920, 3498, 1921, 10360, 3148, 12, 10360, 1005, 13, 2409, 1920, 2740, 1927, 7169, 14141, 16, 2038, 3942, 10360, 1005, 7949, 2518, 12, 10360, 1005, 12, 3]}, "items": [{"id": "p_3201", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3202", "content": "inflammation [SEP] e studied B1R knockout mice (B1R(-/-)) by investigating cardiac inflammation and apoptosis after induction of DOX-induced cardiomyopathy. DO", "tokenized_content": [2, 4531, 3, 47, 3942, 10360, 1005, 7949, 2518, 12, 10360, 1005, 12, 17, 19, 17, 13, 13, 2007, 9651, 4435, 4531, 1930, 4091, 2256, 4408, 1927, 7169, 17, 2719, 14141, 3]}, "items": [{"id": "p_3202", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_3203", "content": "cardiac dysfunction [SEP] nduction of DOX-induced cardiomyopathy. DOX control mice showed cardiac dysfunction measured by pressure-volume loops in vivo. This was associated ", "tokenized_content": [2, 4435, 5273, 3, 8026, 2681, 1927, 7169, 17, 2719, 14141, 18, 7169, 2285, 2518, 2594, 4435, 5273, 3045, 2007, 3772, 17, 3776, 11109, 1922, 3597, 18, 2052, 1982, 2458, 3]}, "items": [{"id": "p_3203", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_3204", "content": "cardiac apoptosis [SEP] ell as an increased bax/bcl2 ratio in Western blots, indicating cardiac apoptosis. Furthermore, mRNA levels of the proinflammatory cytokine inter", "tokenized_content": [2, 4435, 4091, 3, 20430, 1966, 1925, 2502, 10635, 19, 17582, 3400, 1922, 4540, 11305, 16, 4168, 4435, 4091, 18, 3677, 16, 3616, 2428, 1927, 1920, 11064, 6137, 2107, 3]}, "items": [{"id": "p_3204", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_3205", "content": "Hepatotoxicity [SEP] Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case", "tokenized_content": [2, 24126, 3, 24126, 2458, 1956, 5141, 14046, 10119, 1922, 3769, 8884, 30, 43, 3087, 3]}, "items": [{"id": "p_3205", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3206", "content": "sulfasalazine [SEP] Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveilla", "tokenized_content": [2, 5141, 14046, 10119, 3, 24126, 2458, 1956, 5141, 14046, 10119, 1922, 3769, 8884, 30, 43, 3087, 4696, 2037, 43, 3076, 3893, 10888, 3]}, "items": [{"id": "p_3206", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_3207", "content": "arthritis [SEP] Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse eve", "tokenized_content": [2, 8884, 3, 24126, 2458, 1956, 5141, 14046, 10119, 1922, 3769, 8884, 30, 43, 3087, 4696, 2037, 43, 3076, 7889, 1927, 7433, 5246, 2180, 1021, 3]}, "items": [{"id": "p_3207", "content": "Arthritis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8884, 3, 3]}]}
{"query": {"id": "q_3208", "content": "liver failure [SEP] ng anti-rheumatic drugs that was triggered by the occurrence of liver failure in two of our patients. METHODS: Serious ADR reports have been ", "tokenized_content": [2, 3568, 4574, 3, 4375, 2246, 17, 22806, 4195, 1988, 1982, 9436, 2007, 1920, 6564, 1927, 3568, 4574, 1922, 2288, 1927, 2342, 2132, 18, 2860, 30, 7433, 17645, 4710, 2162, 2252, 3]}, "items": [{"id": "p_3208", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_3209", "content": "hepatotoxicity [SEP] regular postcards over the past seven years. Patients', who had hepatotoxicity on sulfasalazine and met a definition of a serious ADR, were id", "tokenized_content": [2, 24126, 3, 6314, 27236, 11663, 2338, 1920, 5375, 5260, 2739, 18, 2132, 11, 16, 2746, 2430, 24126, 1990, 5141, 14046, 10119, 1930, 2130, 43, 6600, 1927, 43, 7433, 17645, 16, 3]}, "items": [{"id": "p_3209", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3210", "content": "sulfasalazine [SEP] over the past seven years. Patients', who had hepatotoxicity on sulfasalazine and met a definition of a serious ADR, were identified. Two cli", "tokenized_content": [2, 5141, 14046, 10119, 3, 2338, 1920, 5375, 5260, 2739, 18, 2132, 11, 16, 2746, 2430, 24126, 1990, 5141, 14046, 10119, 1930, 2130, 43, 6600, 1927, 43, 7433, 17645, 16, 1985, 3]}, "items": [{"id": "p_3210", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_3211", "content": "hepatic failure [SEP] d during surveillance. Eight patients were hospitalised, two in hepatic failure - one died after a liver transplant. All but one event occurred", "tokenized_content": [2, 6095, 4574, 3, 46, 2409, 7889, 18, 5066, 2132, 1985, 3461, 3495, 16, 2288, 1922, 6095, 4574, 17, 2340, 8545, 2256, 43, 3568, 5192, 18, 2136, 2308, 2340, 4817, 4807, 3]}, "items": [{"id": "p_3211", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_3212", "content": "skin rash [SEP] vent occurred within 6 weeks of treatment. Seven patients had a skin rash, three eosinophilia and one interstitial nephritis. Five patien", "tokenized_content": [2, 4407, 18469, 3, 14654, 4807, 2651, 26, 3625, 1927, 2311, 18, 5260, 2132, 2430, 43, 4407, 18469, 16, 2559, 26887, 1930, 2340, 11584, 25064, 18, 3628, 2091, 1917, 3]}, "items": [{"id": "p_3212", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_3213", "content": "eosinophilia [SEP] hin 6 weeks of treatment. Seven patients had a skin rash, three eosinophilia and one interstitial nephritis. Five patients were of Black Bri", "tokenized_content": [2, 26887, 3, 10220, 1022, 26, 3625, 1927, 2311, 18, 5260, 2132, 2430, 43, 4407, 18469, 16, 2559, 26887, 1930, 2340, 11584, 25064, 18, 3628, 2132, 1985, 1927, 5010, 2387, 1033, 3]}, "items": [{"id": "p_3213", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_3214", "content": "interstitial nephritis [SEP] ent. Seven patients had a skin rash, three eosinophilia and one interstitial nephritis. Five patients were of Black British of African or Caribbean de", "tokenized_content": [2, 11584, 25064, 3, 8496, 18, 5260, 2132, 2430, 43, 4407, 18469, 16, 2559, 26887, 1930, 2340, 11584, 25064, 18, 3628, 2132, 1985, 1927, 5010, 14885, 1927, 7050, 2014, 23964, 2028, 3]}, "items": [{"id": "p_3214", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_3215", "content": "amikacin [SEP] An evaluation of amikacin nephrotoxicity in the hematology/oncology population.", "tokenized_content": [2, 15665, 7640, 3665, 3, 1925, 4391, 1927, 15665, 7640, 3665, 27880, 1922, 1920, 27495, 19, 11605, 2973, 18, 3]}, "items": [{"id": "p_3215", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_3216", "content": "nephrotoxicity [SEP] An evaluation of amikacin nephrotoxicity in the hematology/oncology population.", "tokenized_content": [2, 27880, 3, 1925, 4391, 1927, 15665, 7640, 3665, 27880, 1922, 1920, 27495, 19, 11605, 2973, 18, 3]}, "items": [{"id": "p_3216", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3217", "content": "Amikacin [SEP] Amikacin is an aminoglycoside commonly used to provide empirical double ", "tokenized_content": [2, 15665, 7640, 3665, 3, 15665, 7640, 3665, 1977, 1925, 23029, 8028, 5384, 2251, 1942, 3394, 9203, 4825, 3]}, "items": [{"id": "p_3217", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_3218", "content": "aminoglycoside [SEP] Amikacin is an aminoglycoside commonly used to provide empirical double gram-negative treatme", "tokenized_content": [2, 23029, 8028, 3, 15665, 7640, 3665, 1977, 1925, 23029, 8028, 5384, 2251, 1942, 3394, 9203, 4825, 8604, 17, 3136, 2297, 3870, 3]}, "items": [{"id": "p_3218", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_3219", "content": "febrile neutropenia [SEP] ly used to provide empirical double gram-negative treatment for febrile neutropenia and other suspected infections. Strategies of extended-interval", "tokenized_content": [2, 18850, 18005, 3, 7518, 2251, 1942, 3394, 9203, 4825, 8604, 17, 3136, 2311, 1958, 18850, 18005, 1930, 2303, 9407, 5024, 18, 4762, 1927, 6091, 17, 4979, 3]}, "items": [{"id": "p_3219", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3220", "content": "infections [SEP] -negative treatment for febrile neutropenia and other suspected infections. Strategies of extended-interval and conventional dosing have b", "tokenized_content": [2, 5024, 3, 17, 3136, 2311, 1958, 18850, 18005, 1930, 2303, 9407, 5024, 18, 4762, 1927, 6091, 17, 4979, 1930, 5552, 10654, 2162, 44, 3]}, "items": [{"id": "p_3220", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_3221", "content": "amikacin [SEP] ing strategy in the hematology/oncology population. To evaluate amikacin-associated nephrotoxicity in an adult hematology/oncology popul", "tokenized_content": [2, 15665, 7640, 3665, 3, 30393, 4884, 1922, 1920, 27495, 19, 11605, 2973, 18, 1942, 4323, 15665, 7640, 3665, 17, 2458, 27880, 1922, 1925, 4160, 27495, 19, 11605, 2640, 1944, 3]}, "items": [{"id": "p_3221", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_3222", "content": "nephrotoxicity [SEP] hematology/oncology population. To evaluate amikacin-associated nephrotoxicity in an adult hematology/oncology population, a prospective, rand", "tokenized_content": [2, 27880, 3, 27495, 19, 11605, 2973, 18, 1942, 4323, 15665, 7640, 3665, 17, 2458, 27880, 1922, 1925, 4160, 27495, 19, 11605, 2973, 16, 43, 6315, 16, 3315, 3]}, "items": [{"id": "p_3222", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3223", "content": "oncologic disorder [SEP] . Forty patients with a diagnosis consistent with a hematologic/oncologic disorder that required treatment with an aminoglycoside were randomized ", "tokenized_content": [2, 29547, 4770, 3, 18, 11270, 2132, 1956, 43, 3574, 3499, 1956, 43, 18251, 19, 29547, 4770, 1988, 3414, 2311, 1956, 1925, 23029, 8028, 1985, 5542, 3]}, "items": [{"id": "p_3223", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3224", "content": "creatinine [SEP] e occurrence of nephrotoxicity by means of an increase in serum creatinine and evaluation of efficacy via amikacin serum concentrations wi", "tokenized_content": [2, 9374, 3, 47, 6564, 1927, 27880, 2007, 4457, 1927, 1925, 2760, 1922, 3256, 9374, 1930, 4391, 1927, 4348, 3454, 15665, 7640, 3665, 3256, 3295, 11980, 3]}, "items": [{"id": "p_3224", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_3225", "content": "serotonin [SEP] Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users.", "tokenized_content": [2, 11153, 3, 4525, 2347, 1930, 11153, 9054, 4465, 2359, 8218, 1922, 12587, 3857, 18801, 12, 27933, 13, 6603, 18, 3]}, "items": [{"id": "p_3225", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3226", "content": "ecstasy [SEP] unction and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users.", "tokenized_content": [2, 12587, 3857, 18801, 3, 5269, 1929, 1930, 11153, 9054, 4465, 2359, 8218, 1922, 12587, 3857, 18801, 12, 27933, 13, 6603, 18, 3]}, "items": [{"id": "p_3226", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_3227", "content": "MDMA [SEP] nd serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users.", "tokenized_content": [2, 27933, 3, 8026, 11153, 9054, 4465, 2359, 8218, 1922, 12587, 3857, 18801, 12, 27933, 13, 6603, 18, 3]}, "items": [{"id": "p_3227", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_3228", "content": "3,4-methylenedioxymethamphetamine [SEP] Although 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) has been shown to damage brain serotonin (5-H", "tokenized_content": [2, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 3, 2876, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 12, 27933, 2014, 12587, 3857, 18801, 13, 2258, 2252, 2522, 3]}, "items": [{"id": "p_3228", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_3229", "content": "MDMA [SEP] Although 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) has been shown to damage brain serotonin (5-HT) neu", "tokenized_content": [2, 27933, 3, 2876, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 12, 27933, 2014, 12587, 3857, 18801, 13, 2258, 2252, 2522, 1942, 4293, 3068, 11153, 12, 25, 17, 5334, 3]}, "items": [{"id": "p_3229", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_3230", "content": "ecstasy [SEP] Although 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) has been shown to damage brain serotonin (5-HT) neurons in ani", "tokenized_content": [2, 12587, 3857, 18801, 3, 2876, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 12, 27933, 2014, 12587, 3857, 18801, 13, 2258, 2252, 2522, 1942, 4293, 3068, 11153, 12, 25, 3]}, "items": [{"id": "p_3230", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_3231", "content": "serotonin [SEP] ethamphetamine (MDMA or ecstasy) has been shown to damage brain serotonin (5-HT) neurons in animals and possibly humans, little is known ", "tokenized_content": [2, 11153, 3, 3293, 18996, 12, 27933, 2014, 12587, 3857, 18801, 13, 2258, 2252, 2522, 1942, 4293, 3068, 11153, 12, 25, 17, 5334, 13, 3558, 1922, 3555, 1930, 6553, 5209, 16, 3]}, "items": [{"id": "p_3231", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3232", "content": "5-HT [SEP] ine (MDMA or ecstasy) has been shown to damage brain serotonin (5-HT) neurons in animals and possibly humans, little is known about ", "tokenized_content": [2, 25, 17, 5334, 3, 11116, 12, 27933, 2014, 12587, 3857, 18801, 13, 2258, 2252, 2522, 1942, 4293, 3068, 11153, 12, 25, 17, 5334, 13, 3558, 1922, 3555, 1930, 6553, 5209, 3]}, "items": [{"id": "p_3232", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3233", "content": "neurotoxic lesions [SEP]  is known about the long-term consequences of MDMA-induced 5-HT neurotoxic lesions on functions in which 5-HT is involved, such as cognitive funct", "tokenized_content": [2, 20919, 4518, 3, 1977, 3171, 3001, 1920, 2815, 17, 2576, 7080, 1927, 27933, 17, 2719, 25, 17, 5334, 20919, 4518, 1990, 4088, 1922, 2154, 25, 17, 5334, 1977, 3286, 16, 3]}, "items": [{"id": "p_3233", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3234", "content": "memory impairment [SEP] orer on memory tasks than controls. In contrast, no evidence of memory impairment was observed in moderate MDMA users. No significant effect of 5", "tokenized_content": [2, 4525, 6159, 3, 20237, 1005, 1990, 4525, 6840, 2254, 3562, 18, 1922, 3320, 16, 2239, 3095, 1927, 4525, 6159, 1982, 2528, 1922, 5086, 27933, 6603, 18, 2239, 2228, 2495, 1927, 3]}, "items": [{"id": "p_3234", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_3235", "content": "impaired memory functioning [SEP] tities that may be considered \"moderate\" is not associated with impaired memory functioning, heavy use of MDMA use may lead to long lasting memory impairme", "tokenized_content": [2, 5761, 4525, 7295, 3, 7090, 2062, 1988, 2278, 1998, 3311, 6, 5086, 6, 1977, 2084, 2458, 1956, 5761, 4525, 7295, 16, 7881, 2485, 1927, 27933, 2485, 2278, 2949, 1942, 2815, 3]}, "items": [{"id": "p_3235", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_3236", "content": "memory impairments [SEP] ory functioning, heavy use of MDMA use may lead to long lasting memory impairments. No effect of 5-HTTLPR or gender on memory function or MDMA use", "tokenized_content": [2, 4525, 12454, 3, 2014, 1012, 7295, 16, 7881, 2485, 1927, 27933, 2485, 2278, 2949, 1942, 2815, 11671, 4525, 12454, 18, 2239, 2495, 1927, 25, 17, 5136, 13857, 1005, 2014, 5125, 3]}, "items": [{"id": "p_3236", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_3237", "content": "hyperprolactinemia [SEP] ithelial cells of the rat prostate lateral lobe in experimental hyperprolactinemia induced by haloperidol.", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 24737, 3583, 2094, 1927, 1920, 3067, 5683, 5347, 9581, 1922, 3599, 4194, 15743, 11686, 3847, 2719, 2007, 25107, 18, 3]}, "items": [{"id": "p_3237", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_3238", "content": "haloperidol [SEP] tate lateral lobe in experimental hyperprolactinemia induced by haloperidol.", "tokenized_content": [2, 25107, 3, 10687, 1021, 5347, 9581, 1922, 3599, 4194, 15743, 11686, 3847, 2719, 2007, 25107, 18, 3]}, "items": [{"id": "p_3238", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3239", "content": "hyperprolactinemia [SEP] The aim of the study was to examine the influence of hyperprolactinemia, induced by haloperidol (HAL) on age related morphology and fun", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 1920, 3774, 1927, 1920, 2161, 1982, 1942, 5020, 1920, 4039, 1927, 4194, 15743, 11686, 3847, 16, 2719, 2007, 25107, 12, 4217, 13, 1990, 2632, 2712, 3]}, "items": [{"id": "p_3239", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_3240", "content": "haloperidol [SEP]  was to examine the influence of hyperprolactinemia, induced by haloperidol (HAL) on age related morphology and function changes of epithel", "tokenized_content": [2, 25107, 3, 1982, 1942, 5020, 1920, 4039, 1927, 4194, 15743, 11686, 3847, 16, 2719, 2007, 25107, 12, 4217, 13, 1990, 2632, 2712, 6076, 1930, 2347, 2840, 1927, 4240, 1938, 3]}, "items": [{"id": "p_3240", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3241", "content": "HAL [SEP] ne the influence of hyperprolactinemia, induced by haloperidol (HAL) on age related morphology and function changes of epithelial c", "tokenized_content": [2, 4217, 3, 2069, 1920, 4039, 1927, 4194, 15743, 11686, 3847, 16, 2719, 2007, 25107, 12, 4217, 13, 1990, 2632, 2712, 6076, 1930, 2347, 2840, 1927, 4944, 45, 3]}, "items": [{"id": "p_3241", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3242", "content": "PRL [SEP] n sexually mature male rats. Serum concentrations of prolactin (PRL) and testosterone (T) were measured. Tissue sections were evalu", "tokenized_content": [2, 15593, 3, 56, 14427, 6665, 4005, 3615, 18, 3256, 3295, 1927, 18386, 12, 15593, 13, 1930, 10592, 12, 62, 13, 1985, 3045, 18, 2960, 4828, 1985, 2711, 3]}, "items": [{"id": "p_3242", "content": "Prolactin [SEP] A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Be", "score": 1, "type": null, "tokenized_content": [2, 18386, 3, 43, 5641, 3880, 6365, 8366, 2007, 1920, 29639, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5477, 13, 18, 2176, 1977, 43, 13022, 1927, 3993, 3020, 7546, 18, 1998, 3]}]}
{"query": {"id": "q_3243", "content": "testosterone [SEP] y mature male rats. Serum concentrations of prolactin (PRL) and testosterone (T) were measured. Tissue sections were evaluated with light an", "tokenized_content": [2, 10592, 3, 67, 6665, 4005, 3615, 18, 3256, 3295, 1927, 18386, 12, 15593, 13, 1930, 10592, 12, 62, 13, 1985, 3045, 18, 2960, 4828, 1985, 3747, 1956, 3696, 1925, 3]}, "items": [{"id": "p_3243", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_3244", "content": "T [SEP] The aim of the study was to examine the influence of hyperprolact", "tokenized_content": [2, 62, 3, 1920, 3774, 1927, 1920, 2161, 1982, 1942, 5020, 1920, 4039, 1927, 4194, 15743, 2131, 3]}, "items": [{"id": "p_3244", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_3245", "content": "hypertrophy [SEP] n the control group. Light microscopy visualized the following: hypertrophy and epithelium hyperplasia of the glandular ducts, associated w", "tokenized_content": [2, 11014, 3, 56, 1920, 2285, 2210, 18, 3696, 5441, 8559, 1920, 2894, 30, 11014, 1930, 8081, 13095, 1927, 1920, 21808, 19277, 16, 2458, 65, 3]}, "items": [{"id": "p_3245", "content": "Hypertrophy [SEP] General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor ", "score": 1, "type": null, "tokenized_content": [2, 11014, 3, 3335, 2760, 1922, 9390, 1927, 43, 3131, 2014, 3090, 2810, 1942, 2024, 16363, 1930, 4858, 1927, 13315, 1930, 21417, 16, 2084, 2810, 1942, 2798, 3]}]}
{"query": {"id": "q_3246", "content": "hyperplasia [SEP] microscopy visualized the following: hypertrophy and epithelium hyperplasia of the glandular ducts, associated with increased PCNA expressi", "tokenized_content": [2, 13095, 3, 5441, 8559, 1920, 2894, 30, 11014, 1930, 8081, 13095, 1927, 1920, 21808, 19277, 16, 2458, 1956, 2502, 14381, 2190, 1033, 3]}, "items": [{"id": "p_3246", "content": "Hyperplasia [SEP] An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increa", "score": 1, "type": null, "tokenized_content": [2, 13095, 3, 1925, 2760, 1922, 1920, 2529, 1927, 2094, 1922, 43, 2960, 2014, 3090, 2979, 2798, 3337, 18, 2176, 11457, 2037, 11014, 16, 2154, 1977, 1925, 2203, 1019, 3]}]}
{"query": {"id": "q_3247", "content": "vitamin C [SEP] Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?", "tokenized_content": [2, 6111, 45, 3, 3731, 6442, 6111, 45, 2760, 5321, 2573, 2565, 1922, 3089, 1956, 4032, 35, 3]}, "items": [{"id": "p_3247", "content": "Ascorbic Acid [SEP] A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essent", "score": 1, "type": null, "tokenized_content": [2, 18265, 2687, 3, 43, 3798, 5056, 3547, 2712, 1942, 3817, 18, 2176, 1977, 2435, 10414, 1922, 24117, 12953, 1930, 3086, 14206, 18, 18265, 2687, 1977, 1925, 4023, 1939, 3]}]}
{"query": {"id": "q_3248", "content": "cardiovascular disease [SEP] Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?", "tokenized_content": [2, 5321, 2573, 3, 3731, 6442, 6111, 45, 2760, 5321, 2573, 2565, 1922, 3089, 1956, 4032, 35, 3]}, "items": [{"id": "p_3248", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_3249", "content": "diabetes [SEP] al vitamin C increase cardiovascular disease risk in women with diabetes?", "tokenized_content": [2, 4032, 3, 1969, 6111, 45, 2760, 5321, 2573, 2565, 1922, 3089, 1956, 4032, 35, 3]}, "items": [{"id": "p_3249", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_3250", "content": "Vitamin C [SEP] BACKGROUND: Vitamin C acts as a potent antioxidant; however, it can also be a prooxid", "tokenized_content": [2, 6111, 45, 3, 3872, 30, 6111, 45, 8016, 1966, 43, 6828, 7335, 31, 2406, 16, 2176, 2112, 2222, 1998, 43, 1965, 4811, 3]}, "items": [{"id": "p_3250", "content": "Ascorbic Acid [SEP] A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essent", "score": 1, "type": null, "tokenized_content": [2, 18265, 2687, 3, 43, 3798, 5056, 3547, 2712, 1942, 3817, 18, 2176, 1977, 2435, 10414, 1922, 24117, 12953, 1930, 3086, 14206, 18, 18265, 2687, 1977, 1925, 4023, 1939, 3]}]}
{"query": {"id": "q_3251", "content": "vitamin C [SEP]  These observations led us to hypothesize that a high intake of vitamin C in diabetic persons might promote atherosclerosis. OBJECTIVE: T", "tokenized_content": [2, 6111, 45, 3, 2144, 5184, 4866, 2022, 1942, 12880, 1988, 43, 2149, 5240, 1927, 6111, 45, 1922, 6152, 7618, 3284, 5527, 9824, 18, 4470, 30, 62, 3]}, "items": [{"id": "p_3251", "content": "Ascorbic Acid [SEP] A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essent", "score": 1, "type": null, "tokenized_content": [2, 18265, 2687, 3, 43, 3798, 5056, 3547, 2712, 1942, 3817, 18, 2176, 1977, 2435, 10414, 1922, 24117, 12953, 1930, 3086, 14206, 18, 18265, 2687, 1977, 1925, 4023, 1939, 3]}]}
{"query": {"id": "q_3252", "content": "diabetic [SEP] ations led us to hypothesize that a high intake of vitamin C in diabetic persons might promote atherosclerosis. OBJECTIVE: The objective", "tokenized_content": [2, 6152, 3, 2019, 2443, 4866, 2022, 1942, 12880, 1988, 43, 2149, 5240, 1927, 6111, 45, 1922, 6152, 7618, 3284, 5527, 9824, 18, 4470, 30, 1920, 4470, 3]}, "items": [{"id": "p_3252", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_3253", "content": "atherosclerosis [SEP] at a high intake of vitamin C in diabetic persons might promote atherosclerosis. OBJECTIVE: The objective was to examine the relation between v", "tokenized_content": [2, 9824, 3, 2019, 43, 2149, 5240, 1927, 6111, 45, 1922, 6152, 7618, 3284, 5527, 9824, 18, 4470, 30, 1920, 4470, 1982, 1942, 5020, 1920, 6147, 2192, 64, 3]}, "items": [{"id": "p_3253", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_3254", "content": "cardiovascular disease [SEP] xamine the relation between vitamin C intake and mortality from cardiovascular disease. DESIGN: We studied the relation between vitamin C intake and m", "tokenized_content": [2, 5321, 2573, 3, 23447, 25157, 1920, 6147, 2192, 6111, 45, 5240, 1930, 3885, 2037, 5321, 2573, 18, 3036, 30, 2038, 3942, 1920, 6147, 2192, 6111, 45, 5240, 1930, 55, 3]}, "items": [{"id": "p_3254", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_3255", "content": "coronary artery disease [SEP] take and mortality from total cardiovascular disease (n = 281), coronary artery disease (n = 175), and stroke (n = 57) in 1923 postmenopausal women who", "tokenized_content": [2, 5846, 5511, 2573, 3, 6132, 1930, 3885, 2037, 2698, 5321, 2573, 12, 56, 33, 23449, 13, 16, 5846, 5511, 2573, 12, 56, 33, 13919, 13, 16, 1930, 5235, 12, 56, 3]}, "items": [{"id": "p_3255", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_3256", "content": "stroke [SEP] cular disease (n = 281), coronary artery disease (n = 175), and stroke (n = 57) in 1923 postmenopausal women who reported being diabet", "tokenized_content": [2, 5235, 3, 6710, 1933, 2573, 12, 56, 33, 23449, 13, 16, 5846, 5511, 2573, 12, 56, 33, 13919, 13, 16, 1930, 5235, 12, 56, 33, 4786, 13, 1922, 15249, 1010, 3]}, "items": [{"id": "p_3256", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_3257", "content": "diabetes [SEP] ter adjustment for cardiovascular disease risk factors, type of diabetes medication used, duration of diabetes, and intakes of folate, v", "tokenized_content": [2, 4032, 3, 6005, 7970, 1958, 5321, 2573, 2565, 2790, 16, 2601, 1927, 4032, 6093, 2251, 16, 4392, 1927, 4032, 16, 1930, 16134, 1927, 13761, 16, 64, 3]}, "items": [{"id": "p_3257", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_3258", "content": "folate [SEP]  diabetes medication used, duration of diabetes, and intakes of folate, vitamin E, and beta-carotene, the adjusted relative risks of t", "tokenized_content": [2, 13761, 3, 4032, 6093, 2251, 16, 4392, 1927, 4032, 16, 1930, 16134, 1927, 13761, 16, 6111, 47, 16, 1930, 4666, 17, 21498, 16, 1920, 4967, 3338, 7481, 1927, 62, 3]}, "items": [{"id": "p_3258", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_3259", "content": "vitamin E [SEP] s medication used, duration of diabetes, and intakes of folate, vitamin E, and beta-carotene, the adjusted relative risks of total cardio", "tokenized_content": [2, 6111, 47, 3, 61, 6093, 2251, 16, 4392, 1927, 4032, 16, 1930, 16134, 1927, 13761, 16, 6111, 47, 16, 1930, 4666, 17, 21498, 16, 1920, 4967, 3338, 7481, 1927, 2698, 3]}, "items": [{"id": "p_3259", "content": "Vitamin E [SEP] A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydr", "score": 1, "type": null, "tokenized_content": [2, 6111, 47, 3, 43, 13459, 5690, 2684, 1958, 2136, 21432, 1036, 1930, 21682, 18935, 9356, 1036, 1988, 5987, 4595, 17, 21432, 2455, 18, 2007, 25130, 1927, 1920, 14223, 9698, 3]}]}
{"query": {"id": "q_3260", "content": "beta-carotene [SEP] ed, duration of diabetes, and intakes of folate, vitamin E, and beta-carotene, the adjusted relative risks of total cardiovascular disease mo", "tokenized_content": [2, 4666, 17, 21498, 3, 3347, 16, 4392, 1927, 4032, 16, 1930, 16134, 1927, 13761, 16, 6111, 47, 16, 1930, 4666, 17, 21498, 16, 1920, 4967, 3338, 7481, 1927, 2698, 5321, 3]}, "items": [{"id": "p_3260", "content": "beta Carotene [SEP] A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patien", "score": 1, "type": null, "tokenized_content": [2, 4666, 21498, 3, 43, 23779, 1988, 1977, 43, 7897, 1927, 6111, 43, 18, 2176, 1977, 5254, 1942, 4412, 1920, 5155, 1927, 27462, 3273, 5298, 1922, 2091, 1917, 3]}]}
{"query": {"id": "q_3261", "content": "venous thromboembolism [SEP] Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol.", "tokenized_content": [2, 8562, 23821, 3, 6961, 1930, 11081, 2565, 1927, 8562, 23821, 1922, 3089, 1990, 4252, 6120, 23362, 2290, 7959, 1930, 17180, 16323, 2612, 10261, 7408, 1945, 18, 3]}, "items": [{"id": "p_3261", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3262", "content": "cyproterone acetate [SEP] ttributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol.", "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 21504, 2023, 10737, 2565, 1927, 8562, 23821, 1922, 3089, 1990, 4252, 6120, 23362, 2290, 7959, 1930, 17180, 16323, 2612, 10261, 7408, 1945, 18, 3]}, "items": [{"id": "p_3262", "content": "Cyproterone Acetate [SEP] An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen rec", "score": 1, "type": null, "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1925, 5899, 1956, 2246, 17, 10817, 1930, 10759, 4926, 1923, 3879, 18, 2176, 3661, 10362, 2743, 1956, 11842, 17188, 7983, 2019, 10817, 2090, 3]}]}
{"query": {"id": "q_3263", "content": "ethinylestradiol [SEP] us thromboembolism in women on combined cyproterone acetate and ethinylestradiol.", "tokenized_content": [2, 17180, 16323, 2612, 10261, 7408, 1945, 3, 2022, 23821, 1922, 3089, 1990, 4252, 6120, 23362, 2290, 7959, 1930, 17180, 16323, 2612, 10261, 7408, 1945, 18, 3]}, "items": [{"id": "p_3263", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_3264", "content": "venous thromboembolism [SEP] OBJECTIVE: To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol ", "tokenized_content": [2, 8562, 23821, 3, 4470, 30, 1942, 6230, 6961, 2565, 5280, 1927, 8562, 23821, 12, 16931, 13, 2706, 3089, 1990, 6120, 23362, 2290, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 3]}, "items": [{"id": "p_3264", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3265", "content": "VTE [SEP] : To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/", "tokenized_content": [2, 16931, 3, 30, 1942, 6230, 6961, 2565, 5280, 1927, 8562, 23821, 12, 16931, 13, 2706, 3089, 1990, 6120, 23362, 2290, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 12, 22675, 3]}, "items": [{"id": "p_3265", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3266", "content": "cyproterone acetate [SEP] e risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined ora", "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 47, 2565, 5280, 1927, 8562, 23821, 12, 16931, 13, 2706, 3089, 1990, 6120, 23362, 2290, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 12, 22675, 3]}, "items": [{"id": "p_3266", "content": "Cyproterone Acetate [SEP] An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen rec", "score": 1, "type": null, "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1925, 5899, 1956, 2246, 17, 10817, 1930, 10759, 4926, 1923, 3879, 18, 2176, 3661, 10362, 2743, 1956, 11842, 17188, 7983, 2019, 10817, 2090, 3]}]}
{"query": {"id": "q_3267", "content": "ethinylestradiol [SEP] s thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs", "tokenized_content": [2, 17180, 16323, 2612, 10261, 7408, 1945, 3, 61, 23821, 12, 16931, 13, 2706, 3089, 1990, 6120, 23362, 2290, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 12, 22675, 19, 11150, 3]}, "items": [{"id": "p_3267", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_3268", "content": "CPA [SEP] (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs). ME", "tokenized_content": [2, 22675, 3, 12, 16931, 13, 2706, 3089, 1990, 6120, 23362, 2290, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 12, 22675, 19, 11150, 13, 16, 1930, 2706, 3089, 1990, 4252, 3]}, "items": [{"id": "p_3268", "content": "Cyproterone Acetate [SEP] An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen rec", "score": 1, "type": null, "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1925, 5899, 1956, 2246, 17, 10817, 1930, 10759, 4926, 1923, 3879, 18, 2176, 3661, 10362, 2743, 1956, 11842, 17188, 7983, 2019, 10817, 2090, 3]}]}
{"query": {"id": "q_3269", "content": "EE [SEP] ) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs). METHO", "tokenized_content": [2, 11150, 3, 13, 2706, 3089, 1990, 6120, 23362, 2290, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 12, 22675, 19, 11150, 13, 16, 1930, 2706, 3089, 1990, 4252, 4726, 25434, 3]}, "items": [{"id": "p_3269", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_3270", "content": "combined oral contraceptives [SEP] rone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs). METHODS: From the Danish National Register of Patients ", "tokenized_content": [2, 4252, 4726, 25434, 3, 25851, 1021, 7959, 5390, 17180, 16323, 2612, 10261, 7408, 1945, 12, 22675, 19, 11150, 13, 16, 1930, 2706, 3089, 1990, 4252, 4726, 25434, 12, 6880, 1036, 3]}, "items": [{"id": "p_3270", "content": "Contraceptives, Oral, Combined [SEP] Fixed drug combinations administered orally for contraceptive purposes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 16, 4252, 3, 4779, 2838, 7763, 5254, 12950, 1958, 16765, 9323, 18, 3]}]}
{"query": {"id": "q_3271", "content": "COCs [SEP] diol (CPA/EE), and among women on combined oral contraceptives (COCs). METHODS: From the Danish National Register of Patients (NRP),", "tokenized_content": [2, 6880, 1036, 3, 28208, 12, 22675, 19, 11150, 13, 16, 1930, 2706, 3089, 1990, 4252, 4726, 25434, 12, 6880, 1036, 13, 18, 2860, 30, 2037, 1920, 18247, 3852, 13801, 1927, 3]}, "items": [{"id": "p_3271", "content": "Contraceptives, Oral, Combined [SEP] Fixed drug combinations administered orally for contraceptive purposes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 16, 4252, 3, 4779, 2838, 7763, 5254, 12950, 1958, 16765, 9323, 18, 3]}]}
{"query": {"id": "q_3272", "content": "COC [SEP] diol (CPA/EE), and among women on combined oral contraceptives (COCs). METHODS: From the Danish National Register of Patients (NRP)", "tokenized_content": [2, 6880, 3, 28208, 12, 22675, 19, 11150, 13, 16, 1930, 2706, 3089, 1990, 4252, 4726, 25434, 12, 6880, 1036, 13, 18, 2860, 30, 2037, 1920, 18247, 3852, 13801, 1927, 2132, 3]}, "items": [{"id": "p_3272", "content": "Contraceptives, Oral, Combined [SEP] Fixed drug combinations administered orally for contraceptive purposes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 16, 4252, 3, 4779, 2838, 7763, 5254, 12950, 1958, 16765, 9323, 18, 3]}]}
{"query": {"id": "q_3273", "content": "levonorgestrel [SEP] found to have had VTE while on COCs. Of these women, 67 were on levonorgestrel-containing COCs. Eleven were on CPA/EE. The corresponding absol", "tokenized_content": [2, 30129, 11873, 1005, 3190, 5703, 3, 2435, 1942, 2162, 2430, 16931, 2679, 1990, 6880, 1036, 18, 1927, 2144, 3089, 16, 4838, 1985, 1990, 30129, 11873, 1005, 3190, 5703, 17, 3165, 3]}, "items": [{"id": "p_3273", "content": "Levonorgestrel [SEP] A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-", "score": 1, "type": null, "tokenized_content": [2, 30129, 11873, 1005, 3190, 5703, 3, 43, 6830, 10759, 4926, 1923, 6365, 1956, 7728, 2551, 1942, 2690, 1927, 11528, 1930, 3001, 6470, 1966, 6828, 1966, 2496, 7442, 4913, 2014, 12, 15, 17, 3]}]}
{"query": {"id": "q_3274", "content": "lindane [SEP] Effect of lindane on hepatic and brain cytochrome P450s and influence of P450 mod", "tokenized_content": [2, 16401, 2516, 3, 2495, 1927, 16401, 2516, 1990, 6095, 1930, 3068, 9387, 12088, 1036, 1930, 4039, 1927, 12088, 2157, 3]}, "items": [{"id": "p_3274", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3275", "content": "neurotoxicity [SEP] hrome P450s and influence of P450 modulation in lindane induced neurotoxicity.", "tokenized_content": [2, 18034, 3, 3668, 2225, 12088, 1036, 1930, 4039, 1927, 12088, 7145, 1922, 16401, 2516, 2719, 18034, 18, 3]}, "items": [{"id": "p_3275", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3276", "content": "lindane [SEP] Oral administration of lindane (2.5, 5, 10 and 15 mg/kg, body weight) for 5 days was found to ", "tokenized_content": [2, 16401, 2516, 3, 4726, 4183, 1927, 16401, 2516, 12, 22, 18, 25, 16, 25, 16, 2119, 1930, 2461, 2786, 19, 3621, 16, 3362, 3388, 13, 1958, 25, 3000, 1982, 2435, 3]}, "items": [{"id": "p_3276", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3277", "content": "N-nitrosodimethylamine [SEP] O-deethylase (EROD), 7-pentoxyresorufin-O-dealkylase (PROD) and N-nitrosodimethylamine demethylase (NDMA-d) in rat brain and liver. A significant incr", "tokenized_content": [2, 56, 17, 16665, 15799, 21312, 3812, 3, 57, 17, 2028, 5188, 2051, 12, 2668, 1986, 13, 16, 27, 17, 9412, 7221, 2808, 1924, 25824, 1921, 17, 57, 17, 10370, 6716, 3]}, "items": [{"id": "p_3277", "content": "Dimethylnitrosamine [SEP] A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepato", "score": 1, "type": null, "tokenized_content": [2, 9780, 8635, 1997, 17454, 3, 43, 16665, 3812, 10533, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 2176, 5092, 7433, 3568, 4293, 1930, 1977, 43, 5746, 1037, 3]}]}
{"query": {"id": "q_3278", "content": "NDMA [SEP] fin-O-dealkylase (PROD) and N-nitrosodimethylamine demethylase (NDMA-d) in rat brain and liver. A significant increase in the hepati", "tokenized_content": [2, 8026, 3368, 3, 3502, 17, 57, 17, 10370, 6716, 24605, 1021, 12, 21383, 13, 1930, 56, 17, 16665, 15799, 21312, 3812, 21732, 2051, 12, 8026, 3368, 17, 46, 13, 1922, 3]}, "items": [{"id": "p_3278", "content": "Dimethylnitrosamine [SEP] A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepato", "score": 1, "type": null, "tokenized_content": [2, 9780, 8635, 1997, 17454, 3, 43, 16665, 3812, 10533, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 2176, 5092, 7433, 3568, 4293, 1930, 1977, 43, 5746, 1037, 3]}]}
{"query": {"id": "q_3279", "content": "3-methylcholanthrene [SEP] Induction studies have further shown that while pretreatment of 3-methylcholanthrene (MC), an inducer of P4501A1/1A2, did not produce any significan", "tokenized_content": [2, 23, 17, 4963, 22513, 7744, 12063, 3, 4408, 2351, 2162, 2520, 2522, 1988, 2679, 9111, 1927, 23, 17, 4963, 22513, 7744, 12063, 12, 4110, 13, 16, 1925, 18027, 1927, 12088, 3]}, "items": [{"id": "p_3279", "content": "Methylcholanthrene [SEP] A carcinogen that is often used in experimental cancer studies.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 22513, 7744, 12063, 3, 43, 26343, 1988, 1977, 3868, 2251, 1922, 3599, 2539, 2351, 18, 3]}]}
{"query": {"id": "q_3280", "content": "MC [SEP]  further shown that while pretreatment of 3-methylcholanthrene (MC), an inducer of P4501A1/1A2, did not produce any significant ef", "tokenized_content": [2, 4110, 3, 2520, 2522, 1988, 2679, 9111, 1927, 23, 17, 4963, 22513, 7744, 12063, 12, 4110, 13, 16, 1925, 18027, 1927, 12088, 15527, 19, 5123, 1028, 16, 2811, 2084, 5074, 3]}, "items": [{"id": "p_3280", "content": "Methylcholanthrene [SEP] A carcinogen that is often used in experimental cancer studies.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 22513, 7744, 12063, 3, 43, 26343, 1988, 1977, 3868, 2251, 1922, 3599, 2539, 2351, 18, 3]}]}
{"query": {"id": "q_3281", "content": "convulsions [SEP] duce any significant effect in the incidence of lindane induced convulsions, pretreatment with phenobarbital (PB), an inducer of P450 2B1/2", "tokenized_content": [2, 4772, 19389, 3, 10677, 1021, 2967, 2228, 2495, 1922, 1920, 4332, 1927, 16401, 2516, 2719, 4772, 19389, 16, 9111, 1956, 3037, 18986, 12, 5242, 13, 16, 1925, 18027, 1927, 12088, 3]}, "items": [{"id": "p_3281", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3282", "content": "phenobarbital [SEP] the incidence of lindane induced convulsions, pretreatment with phenobarbital (PB), an inducer of P450 2B1/2B2 or ethanol, an inducer of P450", "tokenized_content": [2, 3037, 18986, 3, 1920, 4332, 1927, 16401, 2516, 2719, 4772, 19389, 16, 9111, 1956, 3037, 18986, 12, 5242, 13, 16, 1925, 18027, 1927, 12088, 5751, 1009, 19, 5751, 1028, 2014, 3]}, "items": [{"id": "p_3282", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_3283", "content": "ethanol [SEP] reatment with phenobarbital (PB), an inducer of P450 2B1/2B2 or ethanol, an inducer of P450 2E1 catalysed reactions, significantly incr", "tokenized_content": [2, 5757, 3, 1964, 7647, 1956, 3037, 18986, 12, 5242, 13, 16, 1925, 18027, 1927, 12088, 5751, 1009, 19, 5751, 1028, 2014, 5757, 16, 1925, 18027, 1927, 12088, 11416, 1009, 13928, 3]}, "items": [{"id": "p_3283", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_3284", "content": "cobalt chloride [SEP] ly, when the P450-mediated metabolism of lindane was blocked by cobalt chloride incidence of convulsions was increased in animals treated with ", "tokenized_content": [2, 20773, 9140, 3, 7518, 16, 2469, 1920, 12088, 17, 3434, 4714, 1927, 16401, 2516, 1982, 6923, 2007, 20773, 9140, 4332, 1927, 4772, 19389, 1982, 2502, 1922, 3555, 2868, 1956, 3]}, "items": [{"id": "p_3284", "content": "cobaltous chloride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 20773, 2080, 9140, 3, 3]}]}
{"query": {"id": "q_3285", "content": "toxicity [SEP] l inducible P450 isoenzymes are involved in its neurobehavioral toxicity.", "tokenized_content": [2, 5532, 3, 54, 9376, 12088, 4911, 26897, 2032, 3286, 1922, 2496, 29668, 5532, 18, 3]}, "items": [{"id": "p_3285", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3286", "content": "Seizure [SEP] Seizure associated with sleep deprivation and sustained-release bupropi", "tokenized_content": [2, 11015, 3, 11015, 2458, 1956, 5006, 10837, 1930, 7637, 17, 4012, 22955, 2928, 1033, 3]}, "items": [{"id": "p_3286", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3287", "content": "sleep deprivation [SEP] Seizure associated with sleep deprivation and sustained-release bupropion.", "tokenized_content": [2, 5006, 10837, 3, 11015, 2458, 1956, 5006, 10837, 1930, 7637, 17, 4012, 22955, 2928, 2001, 18, 3]}, "items": [{"id": "p_3287", "content": "Sleep Deprivation [SEP] The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiolog", "score": 1, "type": null, "tokenized_content": [2, 5006, 10837, 3, 1920, 3360, 1927, 3301, 17080, 1927, 5006, 2441, 3599, 2961, 16, 2810, 1942, 3308, 3916, 16, 2014, 2037, 43, 4743, 5386, 1927, 9211, 11149, 2021, 3]}]}
{"query": {"id": "q_3288", "content": "bupropion [SEP] Seizure associated with sleep deprivation and sustained-release bupropion.", "tokenized_content": [2, 22955, 2928, 2001, 3, 11015, 2458, 1956, 5006, 10837, 1930, 7637, 17, 4012, 22955, 2928, 2001, 18, 3]}, "items": [{"id": "p_3288", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_3289", "content": "seizure [SEP] This case report describes a generalized seizure associated with sustained-release bupropion use and sleep depri", "tokenized_content": [2, 11015, 3, 2052, 3087, 3809, 9845, 43, 9612, 11015, 2458, 1956, 7637, 17, 4012, 22955, 2928, 2001, 2485, 1930, 5006, 9061, 1033, 3]}, "items": [{"id": "p_3289", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3290", "content": "bupropion [SEP] scribes a generalized seizure associated with sustained-release bupropion use and sleep deprivation. The subject, a 31-year-old female sm", "tokenized_content": [2, 22955, 2928, 2001, 3, 7572, 2023, 1918, 43, 9612, 11015, 2458, 1956, 7637, 17, 4012, 22955, 2928, 2001, 2485, 1930, 5006, 10837, 18, 1920, 5198, 16, 43, 3470, 17, 2476, 3]}, "items": [{"id": "p_3290", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_3291", "content": "sleep deprivation [SEP] zed seizure associated with sustained-release bupropion use and sleep deprivation. The subject, a 31-year-old female smoker, was participating in", "tokenized_content": [2, 5006, 10837, 3, 6116, 1007, 11015, 2458, 1956, 7637, 17, 4012, 22955, 2928, 2001, 2485, 1930, 5006, 10837, 18, 1920, 5198, 16, 43, 3470, 17, 2476, 17, 4156, 4232, 20411, 3]}, "items": [{"id": "p_3291", "content": "Sleep Deprivation [SEP] The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiolog", "score": 1, "type": null, "tokenized_content": [2, 5006, 10837, 3, 1920, 3360, 1927, 3301, 17080, 1927, 5006, 2441, 3599, 2961, 16, 2810, 1942, 3308, 3916, 16, 2014, 2037, 43, 4743, 5386, 1927, 9211, 11149, 2021, 3]}]}
{"query": {"id": "q_3292", "content": "seizures [SEP] g to a new residence. The patient had no other risk factors for seizures. We suggest that sleep deprivation may add to the risk of bupro", "tokenized_content": [2, 10060, 3, 49, 1942, 43, 2814, 13209, 18, 1920, 2774, 2430, 2239, 2303, 2565, 2790, 1958, 10060, 18, 2038, 3220, 1988, 5006, 10837, 2278, 3019, 1942, 1920, 2565, 1927, 22955, 3]}, "items": [{"id": "p_3292", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3293", "content": "Nephrotoxic [SEP] Nephrotoxic effects in high-risk patients undergoing angiography.", "tokenized_content": [2, 22994, 10605, 3, 22994, 10605, 2564, 1922, 2149, 17, 2565, 2132, 7258, 11676, 18, 3]}, "items": [{"id": "p_3293", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3294", "content": "nephropathy [SEP] BACKGROUND: The use of iodinated contrast medium can result in nephropathy. Whether iso-osmolar contrast medium is less nephrotoxic than l", "tokenized_content": [2, 15582, 3, 3872, 30, 1920, 2485, 1927, 8594, 4597, 3320, 3649, 2112, 3211, 1922, 15582, 18, 3053, 4911, 17, 28046, 3320, 3649, 1977, 2941, 22994, 10605, 2254, 54, 3]}, "items": [{"id": "p_3294", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3295", "content": "nephrotoxic [SEP] ult in nephropathy. Whether iso-osmolar contrast medium is less nephrotoxic than low-osmolar contrast medium in high-risk patients is uncer", "tokenized_content": [2, 22994, 10605, 3, 3570, 1031, 1922, 15582, 18, 3053, 4911, 17, 28046, 3320, 3649, 1977, 2941, 22994, 10605, 2254, 2330, 17, 28046, 3320, 3649, 1922, 2149, 17, 2565, 2132, 1977, 3]}, "items": [{"id": "p_3295", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3296", "content": "iodixanol [SEP] c effects of an iso-osmolar, dimeric, nonionic contrast medium, iodixanol, with those of a low-osmolar, nonionic, monomeric contrast medi", "tokenized_content": [2, 8594, 2416, 4296, 3, 45, 2564, 1927, 1925, 4911, 17, 28046, 16, 18150, 16, 2447, 14207, 3320, 3649, 16, 8594, 2416, 4296, 16, 1956, 2690, 1927, 43, 2330, 17, 28046, 3]}, "items": [{"id": "p_3296", "content": "iodixanol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8594, 2416, 4296, 3, 3]}]}
{"query": {"id": "q_3297", "content": "iohexol [SEP] th those of a low-osmolar, nonionic, monomeric contrast medium, iohexol. The study involved 129 patients with diabetes with serum creat", "tokenized_content": [2, 21509, 17797, 1945, 3, 1913, 2690, 1927, 43, 2330, 17, 28046, 16, 2447, 14207, 16, 14457, 3320, 3649, 16, 21509, 17797, 1945, 18, 1920, 2161, 3286, 9367, 2132, 1956, 4032, 3]}, "items": [{"id": "p_3297", "content": "Iohexol [SEP] An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriograph", "score": 1, "type": null, "tokenized_content": [2, 21509, 17797, 1945, 3, 1925, 3655, 2447, 17, 11478, 16, 3224, 17, 6622, 3320, 5899, 2154, 1977, 2251, 1922, 5707, 3796, 16, 9273, 6405, 5524, 25818, 16, 7737, 1931, 9506, 3796, 16, 12480, 2893, 3]}]}
{"query": {"id": "q_3298", "content": "diabetes [SEP]  contrast medium, iohexol. The study involved 129 patients with diabetes with serum creatinine concentrations of 1.5 to 3.5 mg per decil", "tokenized_content": [2, 4032, 3, 3320, 3649, 16, 21509, 17797, 1945, 18, 1920, 2161, 3286, 9367, 2132, 1956, 4032, 1956, 3256, 9374, 3295, 1927, 21, 18, 25, 1942, 23, 18, 25, 2786, 2079, 3]}, "items": [{"id": "p_3298", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_3299", "content": "creatinine [SEP] hexol. The study involved 129 patients with diabetes with serum creatinine concentrations of 1.5 to 3.5 mg per deciliter who underwent cor", "tokenized_content": [2, 9374, 3, 7142, 1945, 18, 1920, 2161, 3286, 9367, 2132, 1956, 4032, 1956, 3256, 9374, 3295, 1927, 21, 18, 25, 1942, 23, 18, 25, 2786, 2079, 2344, 5912, 1967, 2746, 3]}, "items": [{"id": "p_3299", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_3300", "content": "Nephropathy [SEP] [95 percent confidence interval, -0.34 to -0.07]). CONCLUSIONS: Nephropathy induced by contrast medium may be less likely to develop in hig", "tokenized_content": [2, 15582, 3, 37, 3002, 3564, 5203, 4979, 16, 17, 20, 18, 3540, 1942, 17, 20, 18, 6627, 39, 13, 18, 4355, 30, 15582, 2719, 2007, 3320, 3649, 2278, 1998, 2941, 3]}, "items": [{"id": "p_3300", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3301", "content": "pain [SEP] Experimental cranial pain elicited by capsaicin: a PET study.", "tokenized_content": [2, 3594, 3, 3599, 13598, 3594, 9856, 2007, 19156, 30, 43, 5889, 2161, 18, 3]}, "items": [{"id": "p_3301", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3302", "content": "capsaicin [SEP] Experimental cranial pain elicited by capsaicin: a PET study.", "tokenized_content": [2, 19156, 3, 3599, 13598, 3594, 9856, 2007, 19156, 30, 43, 5889, 2161, 18, 3]}, "items": [{"id": "p_3302", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_3303", "content": "migraine [SEP] n emission tomography (PET) study it was shown recently that in migraine without aura certain areas in the brain stem were activated dur", "tokenized_content": [2, 13258, 3, 56, 7184, 7876, 12, 5889, 13, 2161, 2176, 1982, 2522, 3998, 1988, 1922, 13258, 2979, 11826, 1019, 4908, 3957, 1922, 1920, 3068, 4402, 1985, 4128, 2335, 3]}, "items": [{"id": "p_3303", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_3304", "content": "headache [SEP]  aura certain areas in the brain stem were activated during the headache state, but not in the headache free interval. It was suggested ", "tokenized_content": [2, 12187, 3, 11826, 1019, 4908, 3957, 1922, 1920, 3068, 4402, 1985, 4128, 2409, 1920, 12187, 3360, 16, 2308, 2084, 1922, 1920, 12187, 3294, 4979, 18, 2176, 1982, 3978, 3]}, "items": [{"id": "p_3304", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_3305", "content": "pain [SEP] enerator'. To test this hypothesis we performed an experimental pain study in seven healthy volunteers, using the same positioning i", "tokenized_content": [2, 3594, 3, 2066, 7124, 2684, 11, 18, 1942, 2648, 2052, 4676, 2038, 2593, 1925, 3599, 3594, 2161, 1922, 5260, 4097, 9701, 16, 2193, 1920, 2841, 12158, 51, 3]}, "items": [{"id": "p_3305", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3306", "content": "capsaicin [SEP]  the PET scanner as in the migraine patients. A small amount of capsaicin was administered subcutaneously in the right forehead to evoke ", "tokenized_content": [2, 19156, 3, 1920, 5889, 12240, 1966, 1922, 1920, 13258, 2132, 18, 43, 2858, 4351, 1927, 19156, 1982, 5254, 15554, 1922, 1920, 3659, 9023, 10611, 1942, 24074, 3]}, "items": [{"id": "p_3306", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_3307", "content": "painful [SEP] istered subcutaneously in the right forehead to evoke a burning painful sensation in the first division of the trigeminal nerve. Increa", "tokenized_content": [2, 15806, 3, 1977, 3188, 15554, 1922, 1920, 3659, 9023, 10611, 1942, 24074, 43, 22873, 15806, 15826, 1922, 1920, 2561, 8451, 1927, 1920, 20747, 5507, 18, 2203, 1019, 3]}, "items": [{"id": "p_3307", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3308", "content": "cluster headache [SEP] rather than in a specific type of headache as was suggested for cluster headache.", "tokenized_content": [2, 4377, 12187, 3, 4356, 2254, 1922, 43, 2487, 2601, 1927, 12187, 1966, 1982, 3978, 1958, 4377, 12187, 18, 3]}, "items": [{"id": "p_3308", "content": "Cluster Headache [SEP] A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal o", "score": 1, "type": null, "tokenized_content": [2, 4377, 12187, 3, 43, 3065, 12187, 4770, 1988, 1977, 4378, 2007, 4010, 16, 14470, 12059, 3594, 2154, 1977, 13536, 16, 21038, 4174, 2915, 16, 5338, 57, 3]}]}
{"query": {"id": "q_3309", "content": "Neuroleptic malignant syndrome [SEP] Neuroleptic malignant syndrome with risperidone.", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 20325, 17920, 6558, 4741, 1956, 26991, 18, 3]}, "items": [{"id": "p_3309", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_3310", "content": "risperidone [SEP] Neuroleptic malignant syndrome with risperidone.", "tokenized_content": [2, 26991, 3, 20325, 17920, 6558, 4741, 1956, 26991, 18, 3]}, "items": [{"id": "p_3310", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3311", "content": "Neuroleptic malignant syndrome [SEP] Neuroleptic malignant syndrome is thought to be a result of dopamine D2 receptor blockade in t", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 20325, 17920, 6558, 4741, 1977, 6212, 1942, 1998, 43, 3211, 1927, 7964, 8631, 3148, 9847, 1922, 62, 3]}, "items": [{"id": "p_3311", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_3312", "content": "dopamine [SEP] Neuroleptic malignant syndrome is thought to be a result of dopamine D2 receptor blockade in the striatum of the basal ganglia. Risp", "tokenized_content": [2, 7964, 3, 20325, 17920, 6558, 4741, 1977, 6212, 1942, 1998, 43, 3211, 1927, 7964, 8631, 3148, 9847, 1922, 1920, 11259, 1927, 1920, 5342, 13086, 18, 2511, 1034, 3]}, "items": [{"id": "p_3312", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3313", "content": "Risperidone [SEP] mine D2 receptor blockade in the striatum of the basal ganglia. Risperidone, a benzisoxazole derivative antipsychotic, has high serotonin 5", "tokenized_content": [2, 26991, 3, 24165, 8631, 3148, 9847, 1922, 1920, 11259, 1927, 1920, 5342, 13086, 18, 26991, 16, 43, 7334, 23854, 11414, 13642, 1952, 10533, 17581, 16, 2258, 2149, 11153, 25, 3]}, "items": [{"id": "p_3313", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3314", "content": "benzisoxazole [SEP] r blockade in the striatum of the basal ganglia. Risperidone, a benzisoxazole derivative antipsychotic, has high serotonin 5-HT2 receptor blo", "tokenized_content": [2, 7334, 23854, 11414, 13642, 1952, 3, 60, 9847, 1922, 1920, 11259, 1927, 1920, 5342, 13086, 18, 26991, 16, 43, 7334, 23854, 11414, 13642, 1952, 10533, 17581, 16, 2258, 2149, 11153, 3]}, "items": [{"id": "p_3314", "content": "1,2-benzisoxazole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 22, 17, 7334, 23854, 11414, 13642, 1952, 3, 3]}]}
{"query": {"id": "q_3315", "content": "serotonin [SEP] Risperidone, a benzisoxazole derivative antipsychotic, has high serotonin 5-HT2 receptor blockade and dose-related D2 receptor blockade. ", "tokenized_content": [2, 11153, 3, 26991, 16, 43, 7334, 23854, 11414, 13642, 1952, 10533, 17581, 16, 2258, 2149, 11153, 25, 17, 5334, 1028, 3148, 9847, 1930, 3253, 17, 2712, 8631, 3148, 9847, 18, 3]}, "items": [{"id": "p_3315", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3316", "content": "extrapyramidal symptoms [SEP] kade. The high ratio is believed to impart the low frequency of extrapyramidal symptoms with risperidone at low dosages. With this low frequency of ext", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 9580, 3695, 18, 1920, 2149, 3400, 1977, 9283, 1942, 2754, 5263, 1920, 2330, 3528, 1927, 21346, 3553, 25238, 1923, 3601, 1956, 26991, 2019, 2330, 3]}, "items": [{"id": "p_3316", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3317", "content": "risperidone [SEP] ved to impart the low frequency of extrapyramidal symptoms with risperidone at low dosages. With this low frequency of extrapyramidal sympt", "tokenized_content": [2, 26991, 3, 3428, 1007, 1942, 2754, 5263, 1920, 2330, 3528, 1927, 21346, 3553, 25238, 1923, 3601, 1956, 26991, 2019, 2330, 20549, 18, 1956, 2052, 2330, 3528, 1927, 21346, 3553, 25238, 3]}, "items": [{"id": "p_3317", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3318", "content": "neuroleptic malignant syndrome [SEP] ncy of extrapyramidal symptoms, it was thought the frequency of neuroleptic malignant syndrome might also be lowered. A 73-year-old woman developed neurolepti", "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 5301, 1012, 1927, 21346, 3553, 25238, 1923, 3601, 16, 2176, 1982, 6212, 1920, 3528, 1927, 20325, 17920, 6558, 4741, 3284, 2222, 1998, 13786, 18, 43, 3]}, "items": [{"id": "p_3318", "content": "Neuroleptic Malignant Syndrome [SEP] A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in tur", "score": 1, "type": null, "tokenized_content": [2, 20325, 17920, 6558, 4741, 3, 43, 5063, 11990, 4741, 2458, 5985, 1956, 1920, 2485, 1927, 20325, 17920, 4820, 12, 3365, 17581, 4820, 13, 2154, 2032, 1922, 7431, 3]}]}
{"query": {"id": "q_3319", "content": "dantrolene [SEP] sed after discontinuing risperidone and starting treatment with dantrolene and bromocriptine. It appears that the protection from extrapyr", "tokenized_content": [2, 11434, 1997, 2456, 2912, 3, 6276, 2256, 9035, 13768, 26991, 1930, 6801, 2311, 1956, 11434, 1997, 2456, 2912, 1930, 21392, 4093, 2053, 18, 2176, 5107, 1988, 1920, 6202, 2037, 21346, 3]}, "items": [{"id": "p_3319", "content": "Dantrolene [SEP] Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasti", "score": 1, "type": null, "tokenized_content": [2, 11434, 1997, 2456, 2912, 3, 7345, 3760, 7327, 2031, 1988, 8016, 2007, 13369, 1956, 8392, 17, 8332, 7590, 1922, 1920, 3760, 6832, 18, 2176, 1977, 2251, 1922, 19361, 2156, 1033, 3]}]}
{"query": {"id": "q_3320", "content": "bromocriptine [SEP] ntinuing risperidone and starting treatment with dantrolene and bromocriptine. It appears that the protection from extrapyramidal side effect", "tokenized_content": [2, 21392, 4093, 2053, 3, 5891, 1921, 13768, 26991, 1930, 6801, 2311, 1956, 11434, 1997, 2456, 2912, 1930, 21392, 4093, 2053, 18, 2176, 5107, 1988, 1920, 6202, 2037, 21346, 3553, 25238, 3]}, "items": [{"id": "p_3320", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_3321", "content": "nephrotic syndrome [SEP] extrahepatic angiotensinogen gene expression in rats with acute nephrotic syndrome.", "tokenized_content": [2, 29646, 4741, 3, 29086, 10814, 2404, 2359, 2294, 1922, 3615, 1956, 3939, 29646, 4741, 18, 3]}, "items": [{"id": "p_3321", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3322", "content": "angiotensin [SEP] Plasma concentration and urine excretion of the renin-angiotensin system proteins are altered in rats with nephrotic syndrome (NS", "tokenized_content": [2, 10814, 3, 3582, 3110, 1930, 6960, 11093, 1927, 1920, 16306, 17, 10814, 2433, 2697, 2032, 5520, 1922, 3615, 1956, 29646, 4741, 12, 4246, 3]}, "items": [{"id": "p_3322", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_3323", "content": "nephrotic syndrome [SEP]  the renin-angiotensin system proteins are altered in rats with nephrotic syndrome (NS). In this work the messenger ribonucleic acid (mRNA) levels", "tokenized_content": [2, 29646, 4741, 3, 1920, 16306, 17, 10814, 2433, 2697, 2032, 5520, 1922, 3615, 1956, 29646, 4741, 12, 4246, 13, 18, 1922, 2052, 2778, 1920, 16716, 18347, 1935, 2687, 12, 3616, 3]}, "items": [{"id": "p_3323", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3324", "content": "NS [SEP] in system proteins are altered in rats with nephrotic syndrome (NS). In this work the messenger ribonucleic acid (mRNA) levels of ", "tokenized_content": [2, 4246, 3, 1922, 2433, 2697, 2032, 5520, 1922, 3615, 1956, 29646, 4741, 12, 4246, 13, 18, 1922, 2052, 2778, 1920, 16716, 18347, 1935, 2687, 12, 3616, 13, 2428, 1927, 3]}, "items": [{"id": "p_3324", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3325", "content": "nephrotic [SEP]  the renin-angiotensin system proteins are altered in rats with nephrotic syndrome (NS). In this work the messenger ribonucleic acid (mRN", "tokenized_content": [2, 29646, 3, 1920, 16306, 17, 10814, 2433, 2697, 2032, 5520, 1922, 3615, 1956, 29646, 4741, 12, 4246, 13, 18, 1922, 2052, 2778, 1920, 16716, 18347, 1935, 2687, 12, 2852, 1022, 3]}, "items": [{"id": "p_3325", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3326", "content": "puromycin amino-nucleoside [SEP] and pair-fed (PF) rats. NS was induced by a single injection of puromycin amino-nucleoside (PAN). Although a great urinary excretion and half-normal plasm", "tokenized_content": [2, 19750, 3835, 17, 18015, 3, 1930, 3715, 17, 5788, 12, 5099, 13, 3615, 18, 4246, 1982, 2719, 2007, 43, 2957, 4107, 1927, 19750, 3835, 17, 18015, 12, 3797, 13, 18, 3]}, "items": [{"id": "p_3326", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_3327", "content": "PAN [SEP] as induced by a single injection of puromycin amino-nucleoside (PAN). Although a great urinary excretion and half-normal plasma lev", "tokenized_content": [2, 3797, 3, 1966, 2719, 2007, 43, 2957, 4107, 1927, 19750, 3835, 17, 18015, 12, 3797, 13, 18, 2876, 43, 4733, 7075, 11093, 1930, 4768, 17, 2791, 3582, 10157, 3]}, "items": [{"id": "p_3327", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_3328", "content": "Cyclophosphamide [SEP] Cyclophosphamide associated bladder cancer--a highly aggressive disease: analysi", "tokenized_content": [2, 17135, 3, 17135, 2458, 7821, 2539, 17, 17, 43, 3626, 8704, 2573, 30, 2241, 1033, 3]}, "items": [{"id": "p_3328", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_3329", "content": "bladder cancer [SEP] Cyclophosphamide associated bladder cancer--a highly aggressive disease: analysis of 12 cases.", "tokenized_content": [2, 7821, 2539, 3, 17135, 2458, 7821, 2539, 17, 17, 43, 3626, 8704, 2573, 30, 2333, 1927, 2369, 2919, 18, 3]}, "items": [{"id": "p_3329", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3330", "content": "cyclophosphamide [SEP] e gained knowledge of the etiology, treatment and prevention of cyclophosphamide associated urothelial cancer. MATERIALS AND METHODS: The medica", "tokenized_content": [2, 17135, 3, 47, 11736, 4163, 1927, 1920, 10383, 16, 2311, 1930, 5455, 1927, 17135, 2458, 23182, 2539, 18, 4751, 1930, 2860, 30, 1920, 3935, 1019, 3]}, "items": [{"id": "p_3330", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_3331", "content": "urothelial cancer [SEP] iology, treatment and prevention of cyclophosphamide associated urothelial cancer. MATERIALS AND METHODS: The medical records of 6 men and 6 wome", "tokenized_content": [2, 23182, 2539, 3, 23041, 2021, 1012, 16, 2311, 1930, 5455, 1927, 17135, 2458, 23182, 2539, 18, 4751, 1930, 2860, 30, 1920, 3423, 7123, 1927, 26, 3925, 1930, 26, 26334, 3870, 3]}, "items": [{"id": "p_3331", "content": "Urethral Neoplasms [SEP] Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Pri", "score": 1, "type": null, "tokenized_content": [2, 20409, 15347, 3, 2539, 2014, 3861, 1927, 1920, 28141, 18, 8867, 4944, 3861, 1927, 1920, 28141, 5394, 3149, 1927, 10364, 1930, 20086, 2094, 18, 17618, 3]}]}
{"query": {"id": "q_3332", "content": "bladder cancer [SEP] nd 6 women (mean age 55 years) with cyclophosphamide associated bladder cancer were reviewed. RESULTS: All tumors were grade 3 or 4 transition", "tokenized_content": [2, 7821, 2539, 3, 8026, 26, 3089, 12, 2667, 2632, 4288, 2739, 13, 1956, 17135, 2458, 7821, 2539, 1985, 5487, 18, 2274, 30, 2136, 3861, 1985, 4927, 23, 2014, 24, 4832, 3]}, "items": [{"id": "p_3332", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3333", "content": "tumors [SEP] osphamide associated bladder cancer were reviewed. RESULTS: All tumors were grade 3 or 4 transitional cell carcinoma. Of the 5 patient", "tokenized_content": [2, 3861, 3, 3125, 4151, 16408, 1021, 2458, 7821, 2539, 1985, 5487, 18, 2274, 30, 2136, 3861, 1985, 4927, 23, 2014, 24, 20086, 2024, 5373, 18, 1927, 1920, 25, 2774, 3]}, "items": [{"id": "p_3333", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3334", "content": "carcinoma [SEP] viewed. RESULTS: All tumors were grade 3 or 4 transitional cell carcinoma. Of the 5 patients initially treated with endoscopic resection ", "tokenized_content": [2, 5373, 3, 11103, 18, 2274, 30, 2136, 3861, 1985, 4927, 23, 2014, 24, 20086, 2024, 5373, 18, 1927, 1920, 25, 2132, 6370, 2868, 1956, 10448, 6953, 3]}, "items": [{"id": "p_3334", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3335", "content": "cancer [SEP] atment and prevention of cyclophosphamide associated urothelial cancer. MATERIALS AND METHODS: The medical records of 6 men and 6 wome", "tokenized_content": [2, 2539, 3, 7513, 1939, 1930, 5455, 1927, 17135, 2458, 23182, 2539, 18, 4751, 1930, 2860, 30, 1920, 3423, 7123, 1927, 26, 3925, 1930, 26, 26334, 3870, 3]}, "items": [{"id": "p_3335", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3336", "content": "Cyclophosphamide [SEP] cystectomy for palliation and died 3 months later. CONCLUSIONS: Cyclophosphamide associated bladder tumor is an aggressive disease. However, lon", "tokenized_content": [2, 17135, 3, 20368, 2341, 3542, 1958, 12574, 1943, 1930, 8545, 23, 3221, 3690, 18, 4355, 30, 17135, 2458, 7821, 2798, 1977, 1925, 8704, 2573, 18, 2406, 16, 10969, 3]}, "items": [{"id": "p_3336", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_3337", "content": "bladder tumor [SEP] d died 3 months later. CONCLUSIONS: Cyclophosphamide associated bladder tumor is an aggressive disease. However, long-term survival is possib", "tokenized_content": [2, 7821, 2798, 3, 46, 8545, 23, 3221, 3690, 18, 4355, 30, 17135, 2458, 7821, 2798, 1977, 1925, 8704, 2573, 18, 2406, 16, 2815, 17, 2576, 3298, 1977, 2776, 2023, 3]}, "items": [{"id": "p_3337", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3338", "content": "bladder tumors [SEP] m survival is possible when radical cystectomy is performed for bladder tumors with any sign of invasion and for recurrent high grade disease,", "tokenized_content": [2, 7821, 3861, 3, 55, 3298, 1977, 3216, 2469, 6917, 20368, 2341, 3542, 1977, 2593, 1958, 7821, 3861, 1956, 2967, 2105, 1927, 6254, 1930, 1958, 7457, 2149, 4927, 2573, 16, 3]}, "items": [{"id": "p_3338", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3339", "content": "Leg and back pain [SEP] Leg and back pain after spinal anaesthesia involving hyperbaric 5% lignocaine.", "tokenized_content": [2, 6703, 1930, 3231, 3594, 3, 6703, 1930, 3231, 3594, 2256, 6071, 17107, 5884, 4194, 8751, 1935, 25, 9, 12975, 17678, 18, 3]}, "items": [{"id": "p_3339", "content": "Back Pain [SEP] Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3231, 3594, 3, 3939, 2014, 3724, 3594, 4810, 1922, 1920, 5545, 3451, 1927, 1920, 23755, 31, 5491, 29258, 6312, 1923, 3031, 31, 2014, 1920, 6811, 3451, 18, 3]}]}
{"query": {"id": "q_3340", "content": "lignocaine [SEP]  and back pain after spinal anaesthesia involving hyperbaric 5% lignocaine.", "tokenized_content": [2, 12975, 17678, 3, 1930, 3231, 3594, 2256, 6071, 17107, 5884, 4194, 8751, 1935, 25, 9, 12975, 17678, 18, 3]}, "items": [{"id": "p_3340", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3341", "content": "lignocaine [SEP] Fifty-four patients, aged 27-90 years, who were given lignocaine 5% in 6.8% glucose solution for spinal anaesthesia were studied", "tokenized_content": [2, 12975, 17678, 3, 12357, 17, 3006, 2132, 16, 5177, 3225, 17, 3865, 2739, 16, 2746, 1985, 3258, 12975, 17678, 25, 9, 1922, 26, 18, 28, 9, 3817, 3331, 1958, 6071, 3]}, "items": [{"id": "p_3341", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3342", "content": "glucose [SEP] atients, aged 27-90 years, who were given lignocaine 5% in 6.8% glucose solution for spinal anaesthesia were studied. Thirteen of these", "tokenized_content": [2, 3817, 3, 2019, 6746, 16, 5177, 3225, 17, 3865, 2739, 16, 2746, 1985, 3258, 12975, 17678, 25, 9, 1922, 26, 18, 28, 9, 3817, 3331, 1958, 6071, 17107, 1985, 3942, 3]}, "items": [{"id": "p_3342", "content": "Glucose [SEP] A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in i", "score": 1, "type": null, "tokenized_content": [2, 3817, 3, 43, 3065, 4585, 1927, 3844, 1958, 5818, 7373, 18, 2176, 1977, 10414, 6966, 1930, 1977, 2435, 1922, 12953, 1930, 2303, 7516, 1927, 4793, 1922, 51, 3]}]}
{"query": {"id": "q_3343", "content": "pain in the legs and/or back [SEP] naesthesia were studied. Thirteen of these patients experienced pain in the legs and/or back after recovery from anaesthesia. The patients affected were you", "tokenized_content": [2, 3594, 1922, 1920, 16689, 1930, 19, 2014, 3231, 3, 4049, 29259, 1985, 3942, 18, 18468, 1927, 2144, 2132, 6090, 3594, 1922, 1920, 16689, 1930, 19, 2014, 3231, 2256, 5241, 2037, 3]}, "items": [{"id": "p_3343", "content": "Back Pain [SEP] Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3231, 3594, 3, 3939, 2014, 3724, 3594, 4810, 1922, 1920, 5545, 3451, 1927, 1920, 23755, 31, 5491, 29258, 6312, 1923, 3031, 31, 2014, 1920, 6811, 3451, 18, 3]}]}
{"query": {"id": "q_3344", "content": "pain [SEP] naesthesia were studied. Thirteen of these patients experienced pain in the legs and/or back after recovery from anaesthesia. The pa", "tokenized_content": [2, 3594, 3, 4049, 29259, 1985, 3942, 18, 18468, 1927, 2144, 2132, 6090, 3594, 1922, 1920, 16689, 1930, 19, 2014, 3231, 2256, 5241, 2037, 17107, 18, 1920, 3838, 3]}, "items": [{"id": "p_3344", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3345", "content": "alcohol [SEP]  seven of the 41 patients (17%) without pain admitted to a high alcohol intake, which might be a contributing factor. Leg and/or back p", "tokenized_content": [2, 4284, 3, 5260, 1927, 1920, 4353, 2132, 12, 2752, 9, 13, 2979, 3594, 9723, 1942, 43, 2149, 4284, 5240, 16, 2154, 3284, 1998, 43, 8739, 2991, 18, 6703, 1930, 19, 3]}, "items": [{"id": "p_3345", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_3346", "content": "Leg and/or back pain [SEP] to a high alcohol intake, which might be a contributing factor. Leg and/or back pain is associated with the intrathecal use of hyperbaric 5% lignoca", "tokenized_content": [2, 6703, 1930, 19, 2014, 3231, 3594, 3, 1942, 43, 2149, 4284, 5240, 16, 2154, 3284, 1998, 43, 8739, 2991, 18, 6703, 1930, 19, 2014, 3231, 3594, 1977, 2458, 1956, 1920, 3]}, "items": [{"id": "p_3346", "content": "Back Pain [SEP] Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3231, 3594, 3, 3939, 2014, 3724, 3594, 4810, 1922, 1920, 5545, 3451, 1927, 1920, 23755, 31, 5491, 29258, 6312, 1923, 3031, 31, 2014, 1920, 6811, 3451, 18, 3]}]}
{"query": {"id": "q_3347", "content": "caffeine [SEP] Acute blood pressure elevations with caffeine in men with borderline systemic hypertension.", "tokenized_content": [2, 14119, 3, 3939, 2877, 3772, 17554, 1956, 14119, 1922, 3925, 1956, 16242, 5510, 5579, 18, 3]}, "items": [{"id": "p_3347", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_3348", "content": "hypertension [SEP] essure elevations with caffeine in men with borderline systemic hypertension.", "tokenized_content": [2, 5579, 3, 4023, 2027, 17554, 1956, 14119, 1922, 3925, 1956, 16242, 5510, 5579, 18, 3]}, "items": [{"id": "p_3348", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3349", "content": "caffeine [SEP] Whether the vasoconstrictive actions of caffeine are enhanced in hypertensive persons has not been demonstrated.", "tokenized_content": [2, 14119, 3, 3053, 1920, 28404, 2185, 7728, 1927, 14119, 2032, 4256, 1922, 11706, 7618, 2258, 2084, 2252, 3161, 18, 3]}, "items": [{"id": "p_3349", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_3350", "content": "hypertensive [SEP] hether the vasoconstrictive actions of caffeine are enhanced in hypertensive persons has not been demonstrated. Thus, caffeine (3.3 mg/kg) v", "tokenized_content": [2, 11706, 3, 21997, 2380, 1920, 28404, 2185, 7728, 1927, 14119, 2032, 4256, 1922, 11706, 7618, 2258, 2084, 2252, 3161, 18, 2842, 16, 14119, 12, 23, 18, 23, 2786, 19, 3621, 3]}, "items": [{"id": "p_3350", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3351", "content": "hypertension [SEP]  Hg. Low-risk controls (n = 24) reported no parental history of hypertension and had screening BP < 130/85 mm Hg. Participants were then tes", "tokenized_content": [2, 5579, 3, 7175, 18, 2330, 17, 2565, 3562, 12, 56, 33, 2686, 13, 2568, 2239, 7213, 4403, 1927, 5579, 1930, 2430, 4449, 4149, 32, 8761, 19, 5140, 2489, 7175, 18, 3]}, "items": [{"id": "p_3351", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3352", "content": "Caffeine [SEP] h of 2 protocols; this required a total of 4 laboratory visits. Caffeine-induced changes in diastolic BP were 2 to 3 times larger in bor", "tokenized_content": [2, 14119, 3, 50, 1927, 22, 6997, 31, 2052, 3414, 43, 2698, 1927, 24, 4542, 7870, 18, 14119, 17, 2719, 2840, 1922, 9395, 4149, 1985, 22, 1942, 23, 3586, 4327, 1922, 3]}, "items": [{"id": "p_3352", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_3353", "content": "hypertensives [SEP] ted in 2 protocols, and representative of nearly all borderline hypertensives. We suspect that the potential for caffeine to stabilize high r", "tokenized_content": [2, 11706, 1036, 3, 26080, 1922, 22, 6997, 16, 1930, 5051, 1927, 6737, 2136, 16242, 11706, 1036, 18, 2038, 21339, 1988, 1920, 2889, 1958, 14119, 1942, 13448, 2149, 60, 3]}, "items": [{"id": "p_3353", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3354", "content": "Hallucinations [SEP] Hallucinations and ifosfamide-induced neurotoxicity.", "tokenized_content": [2, 27013, 3, 27013, 1930, 2647, 1951, 6016, 16408, 1021, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3354", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_3355", "content": "ifosfamide [SEP] Hallucinations and ifosfamide-induced neurotoxicity.", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 27013, 1930, 2647, 1951, 6016, 16408, 1021, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3355", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3356", "content": "neurotoxicity [SEP] Hallucinations and ifosfamide-induced neurotoxicity.", "tokenized_content": [2, 18034, 3, 27013, 1930, 2647, 1951, 6016, 16408, 1021, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3356", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3357", "content": "Hallucinations [SEP] BACKGROUND: Hallucinations as a symptom of central neurotoxicity are a known but poorly de", "tokenized_content": [2, 27013, 3, 3872, 30, 27013, 1966, 43, 3226, 1927, 4101, 18034, 2032, 43, 3171, 2308, 7865, 2028, 3]}, "items": [{"id": "p_3357", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_3358", "content": "neurotoxicity [SEP] BACKGROUND: Hallucinations as a symptom of central neurotoxicity are a known but poorly described side effect of ifosfamide. Mos", "tokenized_content": [2, 18034, 3, 3872, 30, 27013, 1966, 43, 3226, 1927, 4101, 18034, 2032, 43, 3171, 2308, 7865, 2910, 4159, 2495, 1927, 2647, 1951, 6016, 16408, 1021, 18, 7500, 3]}, "items": [{"id": "p_3358", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3359", "content": "ifosfamide [SEP] l neurotoxicity are a known but poorly described side effect of ifosfamide. Most cases of ifosfamide-induced hallucinations have been repo", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 54, 18034, 2032, 43, 3171, 2308, 7865, 2910, 4159, 2495, 1927, 2647, 1951, 6016, 16408, 1021, 18, 2501, 2919, 1927, 2647, 1951, 6016, 16408, 3]}, "items": [{"id": "p_3359", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3360", "content": "hallucinations [SEP] bed side effect of ifosfamide. Most cases of ifosfamide-induced hallucinations have been reported with other mental status changes. METHODS: T", "tokenized_content": [2, 27013, 3, 7497, 4159, 2495, 1927, 2647, 1951, 6016, 16408, 1021, 18, 2501, 2919, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 27013, 2162, 2252, 2568, 1956, 2303, 5018, 3642, 3]}, "items": [{"id": "p_3360", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_3361", "content": "hallucinatory [SEP] h may occur without other signs of neurotoxicity. \"Eyes-closed\" hallucinatory experiences appear to be an unusual feature of this presentatio", "tokenized_content": [2, 20958, 13442, 1012, 3, 50, 2278, 4704, 2979, 2303, 6879, 1927, 18034, 18, 6, 7127, 17, 8047, 6, 20958, 13442, 1012, 7651, 3267, 1942, 1998, 1925, 12236, 5961, 1927, 2052, 3]}, "items": [{"id": "p_3361", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_3362", "content": "agitation [SEP] l pharmacologic management of disturbed patients is unclear. If agitation becomes marked, high-potency neuroleptics (i.e., haloperidol) m", "tokenized_content": [2, 18389, 3, 54, 17225, 4280, 1927, 18392, 2132, 1977, 6390, 18, 2647, 18389, 8272, 4961, 16, 2149, 17, 10397, 20325, 17920, 1036, 12, 51, 18, 47, 18, 16, 25107, 13, 3]}, "items": [{"id": "p_3362", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_3363", "content": "haloperidol [SEP] . If agitation becomes marked, high-potency neuroleptics (i.e., haloperidol) may be effective.", "tokenized_content": [2, 25107, 3, 18, 2647, 18389, 8272, 4961, 16, 2149, 17, 10397, 20325, 17920, 1036, 12, 51, 18, 47, 18, 16, 25107, 13, 2278, 1998, 3655, 18, 3]}, "items": [{"id": "p_3363", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3364", "content": "Chlorpropamide [SEP] Chlorpropamide-induced optic neuropathy.", "tokenized_content": [2, 4891, 20194, 5482, 3, 4891, 20194, 5482, 17, 2719, 10109, 13177, 18, 3]}, "items": [{"id": "p_3364", "content": "Chlorpropamide [SEP] A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary mod", "score": 1, "type": null, "tokenized_content": [2, 4891, 20194, 5482, 3, 43, 26496, 16648, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 3]}]}
{"query": {"id": "q_3365", "content": "optic neuropathy [SEP] Chlorpropamide-induced optic neuropathy.", "tokenized_content": [2, 10109, 13177, 3, 4891, 20194, 5482, 17, 2719, 10109, 13177, 18, 3]}, "items": [{"id": "p_3365", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_3366", "content": "adult-onset diabetes [SEP] A 65-year-old woman with adult-onset diabetes treated with chlorpropamide (Diabenese) had a toxic optic neuro", "tokenized_content": [2, 4160, 17, 4727, 4032, 3, 43, 4459, 17, 2476, 17, 4156, 10440, 1956, 4160, 17, 4727, 4032, 2868, 1956, 4891, 20194, 5482, 12, 3517, 11219, 1021, 13, 2430, 43, 6161, 3]}, "items": [{"id": "p_3366", "content": "Diabetes Mellitus, Type 2 [SEP] A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RE", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 16, 2601, 22, 3, 43, 17625, 1927, 4032, 9695, 1988, 1977, 2084, 4122, 17, 8487, 2014, 3100, 12, 17991, 6366, 13, 18, 2176, 1977, 4378, 6370, 2007, 4122, 1964, 3]}]}
{"query": {"id": "q_3367", "content": "chlorpropamide [SEP] A 65-year-old woman with adult-onset diabetes treated with chlorpropamide (Diabenese) had a toxic optic neuropathy that resolved with dis", "tokenized_content": [2, 4891, 20194, 5482, 3, 43, 4459, 17, 2476, 17, 4156, 10440, 1956, 4160, 17, 4727, 4032, 2868, 1956, 4891, 20194, 5482, 12, 3517, 11219, 1021, 13, 2430, 43, 6161, 10109, 3]}, "items": [{"id": "p_3367", "content": "Chlorpropamide [SEP] A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary mod", "score": 1, "type": null, "tokenized_content": [2, 4891, 20194, 5482, 3, 43, 26496, 16648, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 3]}]}
{"query": {"id": "q_3368", "content": "Diabenese [SEP] ld woman with adult-onset diabetes treated with chlorpropamide (Diabenese) had a toxic optic neuropathy that resolved with discontinuatio", "tokenized_content": [2, 3517, 11219, 1021, 3, 5091, 10440, 1956, 4160, 17, 4727, 4032, 2868, 1956, 4891, 20194, 5482, 12, 3517, 11219, 1021, 13, 2430, 43, 6161, 10109, 13177, 1988, 8397, 1956, 9035, 3]}, "items": [{"id": "p_3368", "content": "Chlorpropamide [SEP] A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary mod", "score": 1, "type": null, "tokenized_content": [2, 4891, 20194, 5482, 3, 43, 26496, 16648, 24873, 5899, 2251, 1922, 1920, 2311, 1927, 2447, 17, 4122, 17, 3100, 4032, 9695, 2084, 10884, 1942, 6096, 2157, 3]}]}
{"query": {"id": "q_3369", "content": "toxic optic neuropathy [SEP] lt-onset diabetes treated with chlorpropamide (Diabenese) had a toxic optic neuropathy that resolved with discontinuation of chlorpropamide therapy. V", "tokenized_content": [2, 6161, 10109, 13177, 3, 3457, 17, 4727, 4032, 2868, 1956, 4891, 20194, 5482, 12, 3517, 11219, 1021, 13, 2430, 43, 6161, 10109, 13177, 1988, 8397, 1956, 14775, 1927, 4891, 20194, 3]}, "items": [{"id": "p_3369", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_3370", "content": "Visual loss [SEP] y that resolved with discontinuation of chlorpropamide therapy. Visual loss occurs in diabetics for a variety of reasons, and accurate diag", "tokenized_content": [2, 3737, 3257, 3, 67, 1988, 8397, 1956, 14775, 1927, 4891, 20194, 5482, 3181, 18, 3737, 3257, 5110, 1922, 22127, 1958, 43, 5386, 1927, 6662, 16, 1930, 6305, 25141, 1029, 3]}, "items": [{"id": "p_3370", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_3371", "content": "diabetics [SEP] iscontinuation of chlorpropamide therapy. Visual loss occurs in diabetics for a variety of reasons, and accurate diagnosis is necessary t", "tokenized_content": [2, 22127, 3, 23924, 7562, 10874, 1927, 4891, 20194, 5482, 3181, 18, 3737, 3257, 5110, 1922, 22127, 1958, 43, 5386, 1927, 6662, 16, 1930, 6305, 3574, 1977, 4680, 62, 3]}, "items": [{"id": "p_3371", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_3372", "content": "optic neuropathy [SEP] et diabetes treated with chlorpropamide (Diabenese) had a toxic optic neuropathy that resolved with discontinuation of chlorpropamide therapy. V", "tokenized_content": [2, 10109, 13177, 3, 2140, 4032, 2868, 1956, 4891, 20194, 5482, 12, 3517, 11219, 1021, 13, 2430, 43, 6161, 10109, 13177, 1988, 8397, 1956, 14775, 1927, 4891, 20194, 5482, 3181, 18, 3]}, "items": [{"id": "p_3372", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_3373", "content": "visual loss [SEP] europathy should be considered in the differential diagnosis of visual loss in diabetics.", "tokenized_content": [2, 3737, 3257, 3, 5498, 15935, 3066, 1998, 3311, 1922, 1920, 5611, 3574, 1927, 3737, 3257, 1922, 22127, 18, 3]}, "items": [{"id": "p_3373", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_3374", "content": "Levodopa [SEP] Levodopa-induced dyskinesia and thalamotomy.", "tokenized_content": [2, 26723, 3, 26723, 17, 2719, 3890, 26682, 1930, 10645, 9753, 18, 3]}, "items": [{"id": "p_3374", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3375", "content": "dyskinesia [SEP] Levodopa-induced dyskinesia and thalamotomy.", "tokenized_content": [2, 3890, 26682, 3, 26723, 17, 2719, 3890, 26682, 1930, 10645, 9753, 18, 3]}, "items": [{"id": "p_3375", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3376", "content": "Levodopa [SEP] Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsoni", "tokenized_content": [2, 26723, 3, 26723, 17, 2719, 3890, 26682, 1927, 1920, 14054, 1922, 18468, 2919, 1927, 10124, 1033, 3]}, "items": [{"id": "p_3376", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3377", "content": "dyskinesia [SEP] Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was chore", "tokenized_content": [2, 3890, 26682, 3, 26723, 17, 2719, 3890, 26682, 1927, 1920, 14054, 1922, 18468, 2919, 1927, 26214, 16, 2154, 1982, 11418, 1021, 3]}, "items": [{"id": "p_3377", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3378", "content": "Parkinsonism [SEP] Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviat", "tokenized_content": [2, 26214, 3, 26723, 17, 2719, 3890, 26682, 1927, 1920, 14054, 1922, 18468, 2919, 1927, 26214, 16, 2154, 1982, 11418, 14209, 1030, 16, 9386, 4036, 2014, 10612, 3490, 1922, 2601, 16, 3]}, "items": [{"id": "p_3378", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_3379", "content": "dystonic [SEP] thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviated almost completely by stereotaxic surger", "tokenized_content": [2, 10612, 3490, 3, 18468, 2919, 1927, 26214, 16, 2154, 1982, 11418, 14209, 1030, 16, 9386, 4036, 2014, 10612, 3490, 1922, 2601, 16, 1982, 24228, 5365, 5796, 2007, 28446, 1935, 8107, 3]}, "items": [{"id": "p_3379", "content": "Dystonic Disorders [SEP] Acquired and inherited conditions that feature DYSTONIA as a primary manifestation of disease. These disorders are generally div", "score": 1, "type": null, "tokenized_content": [2, 10612, 3490, 4414, 3, 5815, 1930, 12911, 2961, 1988, 5961, 23357, 1966, 43, 3065, 15570, 1927, 2573, 18, 2144, 4414, 2032, 4933, 6421, 3]}]}
{"query": {"id": "q_3380", "content": "levodopa [SEP]  but much less by the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesions in the course of routin", "tokenized_content": [2, 26723, 3, 2308, 4186, 2941, 2007, 1920, 8420, 1937, 11213, 1957, 5607, 18, 2285, 1927, 26723, 17, 2719, 3890, 26682, 1036, 2007, 17963, 4518, 1922, 1920, 4914, 1927, 10276, 3]}, "items": [{"id": "p_3380", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3381", "content": "dyskinesias [SEP]  the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesions in the course of routine treatment of Parki", "tokenized_content": [2, 3890, 26682, 1036, 3, 1920, 8420, 1937, 11213, 1957, 5607, 18, 2285, 1927, 26723, 17, 2719, 3890, 26682, 1036, 2007, 17963, 4518, 1922, 1920, 4914, 1927, 7341, 2311, 1927, 7607, 3]}, "items": [{"id": "p_3381", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3382", "content": "thalamic lesions [SEP] intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesions in the course of routine treatment of Parkinsonism is discussed", "tokenized_content": [2, 17963, 4518, 3, 11213, 1957, 5607, 18, 2285, 1927, 26723, 17, 2719, 3890, 26682, 1036, 2007, 17963, 4518, 1922, 1920, 4914, 1927, 7341, 2311, 1927, 26214, 1977, 5601, 3]}, "items": [{"id": "p_3382", "content": "Thalamic Diseases [SEP] Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestatio", "score": 1, "type": null, "tokenized_content": [2, 17963, 3902, 3, 4414, 1927, 1920, 20424, 4810, 14893, 16, 2154, 23000, 43, 4743, 3109, 1927, 5586, 1930, 16921, 2988, 18, 7943, 1968, 1037, 3]}]}
{"query": {"id": "q_3383", "content": "nephrotoxicity [SEP] Factors associated with nephrotoxicity and clinical outcome in patients receiving amikacin.", "tokenized_content": [2, 27880, 3, 2790, 2458, 1956, 27880, 1930, 2535, 3924, 1922, 2132, 5962, 15665, 7640, 3665, 18, 3]}, "items": [{"id": "p_3383", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3384", "content": "amikacin [SEP]  with nephrotoxicity and clinical outcome in patients receiving amikacin.", "tokenized_content": [2, 15665, 7640, 3665, 3, 1956, 27880, 1930, 2535, 3924, 1922, 2132, 5962, 15665, 7640, 3665, 18, 3]}, "items": [{"id": "p_3384", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_3385", "content": "amikacin [SEP] Data from 60 patients treated with amikacin were analyzed for factors associated with nephrotoxicity. In 42", "tokenized_content": [2, 15665, 7640, 3665, 3, 2230, 2037, 3276, 2132, 2868, 1956, 15665, 7640, 3665, 1985, 3265, 1958, 2790, 2458, 1956, 27880, 18, 1922, 3858, 3]}, "items": [{"id": "p_3385", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_3386", "content": "nephrotoxicity [SEP] treated with amikacin were analyzed for factors associated with nephrotoxicity. In 42 of these patients, data were examined for factors associ", "tokenized_content": [2, 27880, 3, 2868, 1956, 15665, 7640, 3665, 1985, 3265, 1958, 2790, 2458, 1956, 27880, 18, 1922, 3858, 1927, 2144, 2132, 16, 2230, 1985, 3572, 1958, 2790, 2293, 3]}, "items": [{"id": "p_3386", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3387", "content": "creatinine [SEP] e. Variables evaluated included patient weight, age, sex, serum creatinine level, creatinine clearance, duration of therapy, total dose, m", "tokenized_content": [2, 9374, 3, 47, 18, 3832, 3747, 3063, 2774, 3388, 16, 2632, 16, 3486, 16, 3256, 9374, 2237, 16, 9374, 7802, 16, 4392, 1927, 3181, 16, 2698, 3253, 16, 55, 3]}, "items": [{"id": "p_3387", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_3388", "content": "nephrotoxic [SEP] treated with amikacin were analyzed for factors associated with nephrotoxicity. In 42 of these patients, data were examined for factors ass", "tokenized_content": [2, 22994, 10605, 3, 2868, 1956, 15665, 7640, 3665, 1985, 3265, 1958, 2790, 2458, 1956, 27880, 18, 1922, 3858, 1927, 2144, 2132, 16, 2230, 1985, 3572, 1958, 2790, 2088, 3]}, "items": [{"id": "p_3388", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3389", "content": "cyclosporine [SEP] o subsequent groups of heart transplant recipients. In group I, cyclosporine was given before the procedure at a loading dose of 17.5 mg/kg ", "tokenized_content": [2, 21002, 3, 57, 4521, 2671, 1927, 4003, 5192, 9336, 18, 1922, 2210, 51, 16, 21002, 1982, 3258, 3119, 1920, 4360, 2019, 43, 6693, 3253, 1927, 2752, 18, 25, 2786, 19, 3]}, "items": [{"id": "p_3389", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_3390", "content": "azathioprine [SEP] y after the procedure at a lower dosage and was complemented by azathioprine, which was used for the first postoperative week. Group II show", "tokenized_content": [2, 30499, 5773, 3, 67, 2256, 1920, 4360, 2019, 43, 2826, 9998, 1930, 1982, 17849, 2007, 30499, 5773, 16, 2154, 1982, 2251, 1958, 1920, 2561, 5924, 2982, 18, 2210, 2890, 2146, 3]}, "items": [{"id": "p_3390", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_3391", "content": "urea nitrogen [SEP] etter perioperative renal function as determined by serum blood urea nitrogen and serum creatinine levels. Group II also showed a significant", "tokenized_content": [2, 10505, 6634, 3, 2140, 1967, 14281, 4604, 2347, 1966, 3180, 2007, 3256, 2877, 10505, 6634, 1930, 3256, 9374, 2428, 18, 2210, 2890, 2222, 2594, 43, 2228, 3]}, "items": [{"id": "p_3391", "content": "Blood Urea Nitrogen [SEP] The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% highe", "score": 1, "type": null, "tokenized_content": [2, 2877, 10505, 6634, 3, 1920, 10505, 3110, 1927, 1920, 2877, 9662, 1922, 4430, 1927, 6634, 3919, 18, 3256, 12, 3582, 13, 10505, 6634, 1977, 3993, 2369, 9, 2149, 1021, 3]}]}
{"query": {"id": "q_3392", "content": "creatinine [SEP] l function as determined by serum blood urea nitrogen and serum creatinine levels. Group II also showed a significant decrease of chronic ", "tokenized_content": [2, 9374, 3, 54, 2347, 1966, 3180, 2007, 3256, 2877, 10505, 6634, 1930, 3256, 9374, 2428, 18, 2210, 2890, 2222, 2594, 43, 2228, 3714, 1927, 3724, 3]}, "items": [{"id": "p_3392", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_3393", "content": "nephrotoxicity [SEP]  levels. Group II also showed a significant decrease of chronic nephrotoxicity secondary to long-term therapy with cyclosporine. Despite this ", "tokenized_content": [2, 27880, 3, 2428, 18, 2210, 2890, 2222, 2594, 43, 2228, 3714, 1927, 3724, 27880, 4067, 1942, 2815, 17, 2576, 3181, 1956, 21002, 18, 4281, 2052, 3]}, "items": [{"id": "p_3393", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3394", "content": "cholestasis [SEP] Reversible cholestasis with bile duct injury following azathioprine therapy. A case re", "tokenized_content": [2, 30086, 3, 10743, 30086, 1956, 9619, 10840, 4047, 2894, 30499, 5773, 3181, 18, 43, 3087, 1964, 3]}, "items": [{"id": "p_3394", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3395", "content": "bile duct injury [SEP] Reversible cholestasis with bile duct injury following azathioprine therapy. A case report.", "tokenized_content": [2, 9619, 10840, 4047, 3, 10743, 30086, 1956, 9619, 10840, 4047, 2894, 30499, 5773, 3181, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3395", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3396", "content": "azathioprine [SEP] Reversible cholestasis with bile duct injury following azathioprine therapy. A case report.", "tokenized_content": [2, 30499, 5773, 3, 10743, 30086, 1956, 9619, 10840, 4047, 2894, 30499, 5773, 3181, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3396", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_3397", "content": "polymyositis [SEP] A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clini", "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 43, 4838, 17, 2476, 17, 4156, 2774, 16, 1956, 3065, 3491, 25749, 12924, 3600, 1930, 2979, 2555, 3095, 1927, 3568, 2573, 16, 3530, 2442, 1033, 3]}, "items": [{"id": "p_3397", "content": "Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi", "score": 1, "type": null, "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3902, 4378, 2007, 4531, 5884, 3137, 7848, 18, 2052, 2278, 4704, 1966, 1925, 3939, 2014, 3724, 2625, 2458, 11980, 3]}]}
{"query": {"id": "q_3398", "content": "liver disease [SEP] ent, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholesta", "tokenized_content": [2, 3568, 2573, 3, 8496, 16, 1956, 3065, 3491, 25749, 12924, 3600, 1930, 2979, 2555, 3095, 1927, 3568, 2573, 16, 3530, 2535, 1930, 6503, 4075, 1927, 4010, 21211, 1019, 3]}, "items": [{"id": "p_3398", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3399", "content": "cholestasis [SEP]  disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy. Liver biopsy", "tokenized_content": [2, 30086, 3, 2573, 16, 3530, 2535, 1930, 6503, 4075, 1927, 4010, 30086, 23, 3221, 2256, 6035, 1927, 30499, 5773, 3181, 18, 3568, 6831, 3]}, "items": [{"id": "p_3399", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3400", "content": "azathioprine [SEP] cal features of severe cholestasis 3 months after initiation of azathioprine therapy. Liver biopsy showed cholestasis with both cytological ", "tokenized_content": [2, 30499, 5773, 3, 2570, 4075, 1927, 4010, 30086, 23, 3221, 2256, 6035, 1927, 30499, 5773, 3181, 18, 3568, 6831, 2594, 30086, 1956, 2321, 22004, 3]}, "items": [{"id": "p_3400", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_3401", "content": "Azathioprine [SEP] gical and architectural alterations of interlobular bile ducts. Azathioprine withdrawal resulted after 7 weeks in the resolution of clinical", "tokenized_content": [2, 30499, 5773, 3, 7217, 5657, 1930, 28937, 5996, 1927, 20856, 2389, 2168, 9619, 19277, 18, 30499, 5773, 9594, 4306, 2256, 27, 3625, 1922, 1920, 4885, 1927, 2535, 3]}, "items": [{"id": "p_3401", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_3402", "content": "bile duct injury [SEP] ne-induced cholestasis associated with histological evidence of bile duct injury.", "tokenized_content": [2, 9619, 10840, 4047, 3, 2069, 17, 2719, 30086, 2458, 1956, 6791, 3095, 1927, 9619, 10840, 4047, 18, 3]}, "items": [{"id": "p_3402", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3403", "content": "isoflurane [SEP] Renal function and hemodynamics during prolonged isoflurane-induced hypotension in humans.", "tokenized_content": [2, 15362, 3, 4604, 2347, 1930, 22482, 2409, 7171, 15362, 17, 2719, 16453, 1922, 5209, 18, 3]}, "items": [{"id": "p_3403", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_3404", "content": "hypotension [SEP] l function and hemodynamics during prolonged isoflurane-induced hypotension in humans.", "tokenized_content": [2, 16453, 3, 54, 2347, 1930, 22482, 2409, 7171, 15362, 17, 2719, 16453, 1922, 5209, 18, 3]}, "items": [{"id": "p_3404", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3405", "content": "isoflurane [SEP] The effect of isoflurane-induced hypotension on glomerular function and renal blood flow", "tokenized_content": [2, 15362, 3, 1920, 2495, 1927, 15362, 17, 2719, 16453, 1990, 11655, 2347, 1930, 4604, 2877, 3426, 3]}, "items": [{"id": "p_3405", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_3406", "content": "hypotension [SEP] The effect of isoflurane-induced hypotension on glomerular function and renal blood flow was investigated in", "tokenized_content": [2, 16453, 3, 1920, 2495, 1927, 15362, 17, 2719, 16453, 1990, 11655, 2347, 1930, 4604, 2877, 3426, 1982, 3845, 1922, 3]}, "items": [{"id": "p_3406", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3407", "content": "para-aminohippurate [SEP]  effective renal plasma flow (ERPF) were measured by inulin and para-aminohippurate (PAH) clearance, respectively. Anesthesia was maintained with f", "tokenized_content": [2, 8202, 17, 3835, 27948, 16082, 3, 3655, 4604, 3582, 3426, 12, 15950, 1038, 13, 1985, 3045, 2007, 1922, 3392, 1930, 8202, 17, 3835, 27948, 16082, 12, 13709, 13, 7802, 16, 3]}, "items": [{"id": "p_3407", "content": "p-Aminohippuric Acid [SEP] The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ER", "score": 1, "type": null, "tokenized_content": [2, 58, 17, 3835, 27948, 15861, 2687, 3, 1920, 10646, 13601, 1927, 24, 17, 3835, 13058, 8643, 2687, 18, 2496, 5227, 7012, 1977, 2251, 1966, 43, 4785, 8379, 1942, 2931, 3655, 4604, 3582, 3426, 12, 2668, 3]}]}
{"query": {"id": "q_3408", "content": "PAH [SEP] ma flow (ERPF) were measured by inulin and para-aminohippurate (PAH) clearance, respectively. Anesthesia was maintained with fentan", "tokenized_content": [2, 13709, 3, 2488, 3426, 12, 15950, 1038, 13, 1985, 3045, 2007, 1922, 3392, 1930, 8202, 17, 3835, 27948, 16082, 12, 13709, 13, 7802, 16, 2763, 18, 8871, 1982, 5514, 1956, 3]}, "items": [{"id": "p_3408", "content": "p-Aminohippuric Acid [SEP] The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ER", "score": 1, "type": null, "tokenized_content": [2, 58, 17, 3835, 27948, 15861, 2687, 3, 1920, 10646, 13601, 1927, 24, 17, 3835, 13058, 8643, 2687, 18, 2496, 5227, 7012, 1977, 2251, 1966, 43, 4785, 8379, 1942, 2931, 3655, 4604, 3582, 3426, 12, 2668, 3]}]}
{"query": {"id": "q_3409", "content": "fentanyl [SEP] e (PAH) clearance, respectively. Anesthesia was maintained with fentanyl, nitrous oxide, oxygen, and isoflurane. Hypotension was induced", "tokenized_content": [2, 20311, 3, 47, 12, 13709, 13, 7802, 16, 2763, 18, 8871, 1982, 5514, 1956, 20311, 16, 8686, 1957, 7491, 16, 4612, 16, 1930, 15362, 18, 16453, 1982, 2719, 3]}, "items": [{"id": "p_3409", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_3410", "content": "nitrous oxide [SEP] earance, respectively. Anesthesia was maintained with fentanyl, nitrous oxide, oxygen, and isoflurane. Hypotension was induced for 236.9 +/- ", "tokenized_content": [2, 8686, 1957, 7491, 3, 4352, 2152, 16, 2763, 18, 8871, 1982, 5514, 1956, 20311, 16, 8686, 1957, 7491, 16, 4612, 16, 1930, 15362, 18, 16453, 1982, 2719, 1958, 20098, 18, 3]}, "items": [{"id": "p_3410", "content": "Nitrous Oxide [SEP] Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcoti", "score": 1, "type": null, "tokenized_content": [2, 8686, 1957, 7491, 3, 6634, 7491, 12, 25438, 13, 18, 43, 29500, 16, 12685, 5427, 4422, 1988, 1977, 2251, 1966, 1925, 16111, 1930, 14501, 18, 2149, 3295, 3936, 43, 22872, 13323, 3]}]}
{"query": {"id": "q_3411", "content": "oxygen [SEP] tively. Anesthesia was maintained with fentanyl, nitrous oxide, oxygen, and isoflurane. Hypotension was induced for 236.9 +/- 15.1 min", "tokenized_content": [2, 4612, 3, 8685, 2317, 18, 8871, 1982, 5514, 1956, 20311, 16, 8686, 1957, 7491, 16, 4612, 16, 1930, 15362, 18, 16453, 1982, 2719, 1958, 20098, 18, 29, 15, 19, 17, 3]}, "items": [{"id": "p_3411", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_3412", "content": "Hypotension [SEP] aintained with fentanyl, nitrous oxide, oxygen, and isoflurane. Hypotension was induced for 236.9 +/- 15.1 min by increasing the isoflurane", "tokenized_content": [2, 16453, 3, 9798, 4905, 2368, 1956, 20311, 16, 8686, 1957, 7491, 16, 4612, 16, 1930, 15362, 18, 16453, 1982, 2719, 1958, 20098, 18, 29, 15, 19, 17, 2461, 18, 21, 3]}, "items": [{"id": "p_3412", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3413", "content": "Debrisoquine [SEP] Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmaco", "tokenized_content": [2, 14347, 1037, 15520, 3, 14347, 1037, 15520, 4629, 1930, 1920, 14927, 1930, 4666, 17, 22, 3148, 4602, 1037, 3]}, "items": [{"id": "p_3413", "content": "Debrisoquin [SEP] An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorp", "score": 1, "type": null, "tokenized_content": [2, 14347, 1037, 11072, 3, 1925, 13672, 7428, 17, 7472, 2838, 2551, 1922, 2564, 1942, 13504, 3184, 5802, 18, 2176, 1977, 2222, 13884, 1922, 3301, 43, 4510, 1958, 43, 3491, 12157, 3]}]}
{"query": {"id": "q_3414", "content": "metoprolol [SEP] nd the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers.", "tokenized_content": [2, 2130, 17712, 1945, 3, 8026, 1920, 14927, 1930, 4666, 17, 22, 3148, 24358, 1036, 1927, 2130, 17712, 1945, 1930, 2496, 29532, 18, 3]}, "items": [{"id": "p_3414", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_3415", "content": "metoprolol [SEP] The metabolism of the cardioselective beta-blocker metoprolol is under genetic control of the debrisoquine/sparteine type. Th", "tokenized_content": [2, 2130, 17712, 1945, 3, 1920, 4714, 1927, 1920, 21129, 4127, 25419, 2185, 4666, 17, 14580, 2130, 17712, 1945, 1977, 2441, 3299, 2285, 1927, 1920, 14347, 1037, 15520, 19, 25547, 7595, 3]}, "items": [{"id": "p_3415", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_3416", "content": "debrisoquine [SEP] lective beta-blocker metoprolol is under genetic control of the debrisoquine/sparteine type. The two metabolic phenotypes, extensive (EM) an", "tokenized_content": [2, 14347, 1037, 15520, 3, 17533, 2320, 4666, 17, 14580, 2130, 17712, 1945, 1977, 2441, 3299, 2285, 1927, 1920, 14347, 1037, 15520, 19, 25547, 7595, 2601, 18, 1920, 2288, 4487, 6568, 3]}, "items": [{"id": "p_3416", "content": "Debrisoquin [SEP] An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorp", "score": 1, "type": null, "tokenized_content": [2, 14347, 1037, 11072, 3, 1925, 13672, 7428, 17, 7472, 2838, 2551, 1922, 2564, 1942, 13504, 3184, 5802, 18, 2176, 1977, 2222, 13884, 1922, 3301, 43, 4510, 1958, 43, 3491, 12157, 3]}]}
{"query": {"id": "q_3417", "content": "sparteine [SEP] blocker metoprolol is under genetic control of the debrisoquine/sparteine type. The two metabolic phenotypes, extensive (EM) and poor met", "tokenized_content": [2, 25547, 7595, 3, 14580, 2130, 17712, 1945, 1977, 2441, 3299, 2285, 1927, 1920, 14347, 1037, 15520, 19, 25547, 7595, 2601, 18, 1920, 2288, 4487, 6568, 16, 6475, 12, 2391, 13, 3]}, "items": [{"id": "p_3417", "content": "Sparteine [SEP] A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytoci", "score": 1, "type": null, "tokenized_content": [2, 25547, 7595, 3, 43, 9012, 8436, 27767, 2053, 29951, 3937, 2037, 2980, 6914, 9914, 2710, 12555, 22214, 31, 25547, 11254, 31, 1930, 2702, 1937, 1957, 18, 2176, 2258, 2252, 2251, 1966, 1925, 16462, 2240, 3]}]}
{"query": {"id": "q_3418", "content": "terbutaline [SEP] ol. The drug effect studied was the antagonism by metoprolol of terbutaline-induced hypokalemia. By using pharmacokinetic pharmacodynamic m", "tokenized_content": [2, 6005, 16119, 8177, 3, 2865, 18, 1920, 2838, 2495, 3942, 1982, 1920, 18394, 2007, 2130, 17712, 1945, 1927, 6005, 16119, 8177, 17, 2719, 14395, 7640, 1952, 6026, 18, 2007, 2193, 3]}, "items": [{"id": "p_3418", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_3419", "content": "hypokalemia [SEP] studied was the antagonism by metoprolol of terbutaline-induced hypokalemia. By using pharmacokinetic pharmacodynamic modeling the pharmaco", "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 3942, 1982, 1920, 18394, 2007, 2130, 17712, 1945, 1927, 6005, 16119, 8177, 17, 2719, 14395, 7640, 1952, 6026, 18, 2007, 2193, 12763, 24358, 7081, 1920, 3]}, "items": [{"id": "p_3419", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_3420", "content": "potassium [SEP] se (0.75 mg) on day 2. Blood samples for the analysis of plasma potassium, terbutaline, metoprolol (racemic, R- and S-isomer), and alpha-", "tokenized_content": [2, 9057, 3, 2058, 12, 20, 18, 4089, 2786, 13, 1990, 3007, 22, 18, 2877, 2785, 1958, 1920, 2333, 1927, 3582, 9057, 16, 6005, 16119, 8177, 16, 2130, 17712, 1945, 12, 3]}, "items": [{"id": "p_3420", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_3421", "content": "alpha-hydroxymetoprolol [SEP] assium, terbutaline, metoprolol (racemic, R- and S-isomer), and alpha-hydroxymetoprolol concentrations were taken at regular time intervals, during 8 h", "tokenized_content": [2, 4595, 17, 8275, 14578, 17712, 1945, 3, 2088, 2457, 16, 6005, 16119, 8177, 16, 2130, 17712, 1945, 12, 7442, 4913, 16, 60, 17, 1930, 61, 17, 15348, 13, 16, 1930, 3]}, "items": [{"id": "p_3421", "content": "alpha-hydroxymetoprolol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 8275, 14578, 17712, 1945, 3, 3]}]}
{"query": {"id": "q_3422", "content": "Cefotetan [SEP] Cefotetan-induced immune hemolytic anemia.", "tokenized_content": [2, 13724, 7229, 3285, 3, 13724, 7229, 3285, 17, 2719, 3743, 21515, 10679, 18, 3]}, "items": [{"id": "p_3422", "content": "Cefotetan [SEP] A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a b", "score": 1, "type": null, "tokenized_content": [2, 13724, 7229, 3285, 3, 43, 8762, 18801, 4905, 4116, 2002, 17008, 8527, 4636, 7267, 1988, 1977, 5254, 15132, 2014, 16774, 1954, 18, 1920, 2838, 1977, 3626, 4910, 1942, 43, 44, 3]}]}
{"query": {"id": "q_3423", "content": "hemolytic anemia [SEP] Cefotetan-induced immune hemolytic anemia.", "tokenized_content": [2, 21515, 10679, 3, 13724, 7229, 3285, 17, 2719, 3743, 21515, 10679, 18, 3]}, "items": [{"id": "p_3423", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3424", "content": "hemolytic anemia [SEP] Immune hemolytic anemia due to a drug-adsorption mechanism has been described primarily", "tokenized_content": [2, 21515, 10679, 3, 3743, 21515, 10679, 2810, 1942, 43, 2838, 17, 9724, 2856, 2258, 2252, 2910, 5985, 3]}, "items": [{"id": "p_3424", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3425", "content": "penicillins [SEP] on mechanism has been described primarily in patients receiving penicillins and first-generation cephalosporins. We describe a patient who ", "tokenized_content": [2, 9957, 1036, 3, 1990, 2856, 2258, 2252, 2910, 5985, 1922, 2132, 5962, 9957, 1036, 1930, 2561, 17, 4841, 25091, 2925, 18, 2038, 5993, 43, 2774, 2746, 3]}, "items": [{"id": "p_3425", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_3426", "content": "cephalosporins [SEP] rimarily in patients receiving penicillins and first-generation cephalosporins. We describe a patient who developed anemia while receiving int", "tokenized_content": [2, 25091, 2925, 3, 14764, 4697, 1922, 2132, 5962, 9957, 1036, 1930, 2561, 17, 4841, 25091, 2925, 18, 2038, 5993, 43, 2774, 2746, 3530, 10679, 2679, 5962, 2218, 3]}, "items": [{"id": "p_3426", "content": "Cephalosporins [SEP] A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moie", "score": 1, "type": null, "tokenized_content": [2, 25091, 2925, 3, 43, 2210, 1927, 4949, 17, 5648, 7560, 2561, 3937, 2037, 1920, 16825, 16461, 10428, 1987, 15414, 18, 2611, 5531, 1920, 4666, 17, 15294, 15295, 1021, 3]}]}
{"query": {"id": "q_3427", "content": "anemia [SEP] Immune hemolytic anemia due to a drug-adsorption mechanism has been described primarily", "tokenized_content": [2, 10679, 3, 3743, 21515, 10679, 2810, 1942, 43, 2838, 17, 9724, 2856, 2258, 2252, 2910, 5985, 3]}, "items": [{"id": "p_3427", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3428", "content": "cefotetan [SEP] ribe a patient who developed anemia while receiving intravenous cefotetan. Cefotetan-dependent antibodies were detected in the patient's ", "tokenized_content": [2, 13724, 7229, 3285, 3, 5216, 1021, 43, 2774, 2746, 3530, 10679, 2679, 5962, 7307, 13724, 7229, 3285, 18, 13724, 7229, 3285, 17, 3100, 3788, 1985, 3330, 1922, 1920, 2774, 11, 3]}, "items": [{"id": "p_3428", "content": "Cefotetan [SEP] A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a b", "score": 1, "type": null, "tokenized_content": [2, 13724, 7229, 3285, 3, 43, 8762, 18801, 4905, 4116, 2002, 17008, 8527, 4636, 7267, 1988, 1977, 5254, 15132, 2014, 16774, 1954, 18, 1920, 2838, 1977, 3626, 4910, 1942, 43, 44, 3]}]}
{"query": {"id": "q_3429", "content": "Cefotetan [SEP] ent who developed anemia while receiving intravenous cefotetan. Cefotetan-dependent antibodies were detected in the patient's serum and i", "tokenized_content": [2, 13724, 7229, 3285, 3, 8496, 2746, 3530, 10679, 2679, 5962, 7307, 13724, 7229, 3285, 18, 13724, 7229, 3285, 17, 3100, 3788, 1985, 3330, 1922, 1920, 2774, 11, 61, 3256, 1930, 3]}, "items": [{"id": "p_3429", "content": "Cefotetan [SEP] A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a b", "score": 1, "type": null, "tokenized_content": [2, 13724, 7229, 3285, 3, 43, 8762, 18801, 4905, 4116, 2002, 17008, 8527, 4636, 7267, 1988, 1977, 5254, 15132, 2014, 16774, 1954, 18, 1920, 2838, 1977, 3626, 4910, 1942, 43, 44, 3]}]}
{"query": {"id": "q_3430", "content": "hemolysis [SEP] junction with clinical and laboratory evidence of extravascular hemolysis, are consistent with drug-induced hemolytic anemia, possibly in", "tokenized_content": [2, 22409, 3, 6910, 1956, 2535, 1930, 4542, 3095, 1927, 21263, 18021, 5148, 1005, 22409, 16, 2032, 3499, 1956, 2838, 17, 2719, 21515, 10679, 16, 6553, 1922, 3]}, "items": [{"id": "p_3430", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_3431", "content": "Acute renal failure [SEP] Acute renal failure subsequent to the administration of rifampicin. A follow-up stu", "tokenized_content": [2, 3939, 4604, 4574, 3, 3939, 4604, 4574, 4521, 1942, 1920, 4183, 1927, 22648, 18, 43, 2396, 17, 2353, 1955, 1032, 3]}, "items": [{"id": "p_3431", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_3432", "content": "rifampicin [SEP] Acute renal failure subsequent to the administration of rifampicin. A follow-up study of cases reported earlier.", "tokenized_content": [2, 22648, 3, 3939, 4604, 4574, 4521, 1942, 1920, 4183, 1927, 22648, 18, 43, 2396, 17, 2353, 2161, 1927, 2919, 2568, 5556, 18, 3]}, "items": [{"id": "p_3432", "content": "Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag", "score": 1, "type": null, "tokenized_content": [2, 18332, 1921, 3, 43, 8762, 18801, 4905, 4116, 2002, 7267, 4152, 2037, 22874, 16241, 1033, 18, 2176, 2258, 43, 4949, 13021, 5648, 16, 2710, 2455, 2260, 3]}]}
{"query": {"id": "q_3433", "content": "acute renal failure [SEP] al presentation is made of a 2-3 year follow-up of six cases of acute renal failure that have been reported earlier. The patients had developed tra", "tokenized_content": [2, 3939, 4604, 4574, 3, 1969, 6544, 1977, 3915, 1927, 43, 22, 17, 23, 2476, 2396, 17, 2353, 1927, 3798, 2919, 1927, 3939, 4604, 4574, 1988, 2162, 2252, 2568, 5556, 18, 3]}, "items": [{"id": "p_3433", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_3434", "content": "renal failure [SEP] sentation is made of a 2-3 year follow-up of six cases of acute renal failure that have been reported earlier. The patients had developed tra", "tokenized_content": [2, 4604, 4574, 3, 8437, 1943, 1977, 3915, 1927, 43, 22, 17, 23, 2476, 2396, 17, 2353, 1927, 3798, 2919, 1927, 3939, 4604, 4574, 1988, 2162, 2252, 2568, 5556, 18, 1920, 3]}, "items": [{"id": "p_3434", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3435", "content": "rifampicin [SEP] ransient renal failure after the intermittent administration of rifampicin. The stage of olig-anuria lasted for 1-3 weeks, and five of the", "tokenized_content": [2, 22648, 3, 2845, 12924, 1939, 4604, 4574, 2256, 1920, 13252, 4183, 1927, 22648, 18, 1920, 3587, 1927, 4833, 17, 1925, 8754, 16276, 1958, 21, 17, 23, 3625, 16, 1930, 3628, 3]}, "items": [{"id": "p_3435", "content": "Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag", "score": 1, "type": null, "tokenized_content": [2, 18332, 1921, 3, 43, 8762, 18801, 4905, 4116, 2002, 7267, 4152, 2037, 22874, 16241, 1033, 18, 2176, 2258, 43, 4949, 13021, 5648, 16, 2710, 2455, 2260, 3]}]}
{"query": {"id": "q_3436", "content": "anuria [SEP] he intermittent administration of rifampicin. The stage of olig-anuria lasted for 1-3 weeks, and five of the patients were treated by ", "tokenized_content": [2, 1925, 8754, 3, 2234, 13252, 4183, 1927, 22648, 18, 1920, 3587, 1927, 4833, 17, 1925, 8754, 16276, 1958, 21, 17, 23, 3625, 16, 1930, 3628, 1927, 1920, 2132, 1985, 2868, 3]}, "items": [{"id": "p_3436", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_3437", "content": "renal lesions [SEP] renography was slightly slowed. Although in the acute stage the renal lesions histologically appeared toxic, evidence suggestive of an immuno", "tokenized_content": [2, 4604, 4518, 3, 3866, 3796, 1982, 5733, 21590, 18, 2876, 1922, 1920, 3939, 3587, 1920, 4604, 4518, 15055, 6209, 6161, 16, 3095, 12855, 1927, 1925, 6595, 3]}, "items": [{"id": "p_3437", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3438", "content": "Type B hepatitis [SEP] Type B hepatitis after needle-stick exposure: prevention with hepatitis B immune", "tokenized_content": [2, 2601, 44, 7977, 3, 2601, 44, 7977, 2256, 9351, 17, 19774, 3395, 30, 5455, 1956, 7977, 44, 3743, 3]}, "items": [{"id": "p_3438", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_3439", "content": "hepatitis B [SEP] Type B hepatitis after needle-stick exposure: prevention with hepatitis B immune globulin. Final report of the Veterans Administration Co", "tokenized_content": [2, 7977, 44, 3, 2601, 44, 7977, 2256, 9351, 17, 19774, 3395, 30, 5455, 1956, 7977, 44, 3743, 24366, 18, 3948, 3809, 1927, 1920, 14696, 4183, 2081, 3]}, "items": [{"id": "p_3439", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_3440", "content": "Hepatitis B [SEP] Hepatitis B immune globulin (HBIG) and immune serum globulin (ISG) were exa", "tokenized_content": [2, 7977, 44, 3, 7977, 44, 3743, 24366, 12, 4873, 1950, 13, 1930, 3743, 3256, 24366, 12, 22443, 13, 1985, 1975, 1019, 3]}, "items": [{"id": "p_3440", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_3441", "content": "type B hepatitis [SEP] e-blind trial to assess their relative efficacies in preventing type B hepatitis after needle-stick exposure to hepatitis B surface antigen (HBs", "tokenized_content": [2, 2601, 44, 7977, 3, 47, 17, 7109, 3046, 1942, 2634, 2310, 3338, 14507, 2062, 1922, 8444, 2601, 44, 7977, 2256, 9351, 17, 19774, 3395, 1942, 7977, 44, 3154, 4730, 12, 3]}, "items": [{"id": "p_3441", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_3442", "content": "hepatitis B surface antigen [SEP] s in preventing type B hepatitis after needle-stick exposure to hepatitis B surface antigen (HBsAG)-positive donors. Clinical hepatitis developed in 1.4% o", "tokenized_content": [2, 7977, 44, 3154, 4730, 3, 61, 1922, 8444, 2601, 44, 7977, 2256, 9351, 17, 19774, 3395, 1942, 7977, 44, 3154, 4730, 12, 17596, 13, 17, 2843, 8276, 18, 2535, 7977, 3]}, "items": [{"id": "p_3442", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_3443", "content": "HBsAG [SEP] tis after needle-stick exposure to hepatitis B surface antigen (HBsAG)-positive donors. Clinical hepatitis developed in 1.4% of HBIG ", "tokenized_content": [2, 17596, 3, 30152, 2256, 9351, 17, 19774, 3395, 1942, 7977, 44, 3154, 4730, 12, 17596, 13, 17, 2843, 8276, 18, 2535, 7977, 3530, 1922, 21, 18, 24, 9, 1927, 4873, 3]}, "items": [{"id": "p_3443", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_3444", "content": "hepatitis [SEP]  trial to assess their relative efficacies in preventing type B hepatitis after needle-stick exposure to hepatitis B surface antigen (HBs", "tokenized_content": [2, 7977, 3, 3046, 1942, 2634, 2310, 3338, 14507, 2062, 1922, 8444, 2601, 44, 7977, 2256, 9351, 17, 19774, 3395, 1942, 7977, 44, 3154, 4730, 12, 11500, 3]}, "items": [{"id": "p_3444", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3445", "content": "HBeAg [SEP]  examined for DNA polymerase (DNAP) and e antigen and antibody (HBeAg; anti-HBE). Both DNAP and HBeAg showed a highly statistically s", "tokenized_content": [2, 25162, 3, 3572, 1958, 2678, 6479, 12, 2678, 1034, 13, 1930, 47, 4730, 1930, 3533, 12, 25162, 31, 2246, 17, 20508, 13, 18, 2321, 2678, 1034, 1930, 25162, 2594, 43, 3]}, "items": [{"id": "p_3445", "content": "Hepatitis B e Antigens [SEP] A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic he", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 47, 7769, 3, 43, 6538, 2712, 2210, 1927, 7769, 2435, 1922, 1920, 3582, 2444, 2409, 1920, 20905, 3193, 1927, 7977, 44, 2014, 1922, 18354, 3724, 2234, 3]}]}
{"query": {"id": "q_3446", "content": "HBsAg [SEP] y statistically significant correlation with the infectivity of HBsAg-positive donors. Hepatitis B immune globulin remained significa", "tokenized_content": [2, 17596, 3, 67, 4388, 2228, 3670, 1956, 1920, 16217, 1927, 17596, 17, 2843, 8276, 18, 7977, 44, 3743, 24366, 5410, 2208, 1019, 3]}, "items": [{"id": "p_3446", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_3447", "content": "Serotonin syndrome [SEP] Serotonin syndrome from venlafaxine-tranylcypromine interaction.", "tokenized_content": [2, 11153, 4741, 3, 11153, 4741, 2037, 8102, 5148, 6016, 25204, 17, 29808, 2199, 13796, 2216, 25157, 2835, 18, 3]}, "items": [{"id": "p_3447", "content": "Serotonin Syndrome [SEP] An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It i", "score": 1, "type": null, "tokenized_content": [2, 11153, 4741, 3, 1925, 5246, 2838, 2835, 4378, 2007, 5520, 5018, 3642, 16, 13725, 5273, 16, 1930, 15829, 6754, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3448", "content": "venlafaxine [SEP] Serotonin syndrome from venlafaxine-tranylcypromine interaction.", "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 11153, 4741, 2037, 8102, 5148, 6016, 25204, 17, 29808, 2199, 13796, 2216, 25157, 2835, 18, 3]}, "items": [{"id": "p_3448", "content": "venlafaxine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 3]}]}
{"query": {"id": "q_3449", "content": "tranylcypromine [SEP] Serotonin syndrome from venlafaxine-tranylcypromine interaction.", "tokenized_content": [2, 29808, 2199, 13796, 2216, 25157, 3, 11153, 4741, 2037, 8102, 5148, 6016, 25204, 17, 29808, 2199, 13796, 2216, 25157, 2835, 18, 3]}, "items": [{"id": "p_3449", "content": "Tranylcypromine [SEP] A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the", "score": 1, "type": null, "tokenized_content": [2, 29808, 2199, 13796, 2216, 25157, 3, 43, 20299, 3812, 5333, 2037, 1920, 25267, 1927, 1920, 4159, 4659, 1927, 19057, 18, 2052, 25368, 10488, 4106, 1977, 3655, 1922, 1920, 3]}]}
{"query": {"id": "q_3450", "content": "serotonin [SEP] Excessive stimulation of serotonin 5HT1A receptors causes a syndrome of serotonin excess that cons", "tokenized_content": [2, 11153, 3, 9122, 4177, 1927, 11153, 29621, 6146, 4086, 5092, 43, 4741, 1927, 11153, 5799, 1988, 2134, 3]}, "items": [{"id": "p_3450", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3451", "content": "muscle rigidity [SEP] uses a syndrome of serotonin excess that consists of shivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. The most co", "tokenized_content": [2, 3760, 20471, 3, 7947, 43, 4741, 1927, 11153, 5799, 1988, 7543, 1927, 20837, 2004, 1941, 16, 3760, 20471, 16, 12999, 1929, 16, 18272, 16, 18389, 1930, 21945, 18, 1920, 2501, 3]}, "items": [{"id": "p_3451", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_3452", "content": "salivation [SEP] f serotonin excess that consists of shivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. The most common cause o", "tokenized_content": [2, 12999, 1929, 3, 48, 11153, 5799, 1988, 7543, 1927, 20837, 2004, 1941, 16, 3760, 20471, 16, 12999, 1929, 16, 18272, 16, 18389, 1930, 21945, 18, 1920, 2501, 3059, 3936, 57, 3]}, "items": [{"id": "p_3452", "content": "Sialorrhea [SEP] Increased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12952, 21588, 3, 2502, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_3453", "content": "confusion [SEP] excess that consists of shivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. The most common cause of this synd", "tokenized_content": [2, 18272, 3, 5799, 1988, 7543, 1927, 20837, 2004, 1941, 16, 3760, 20471, 16, 12999, 1929, 16, 18272, 16, 18389, 1930, 21945, 18, 1920, 2501, 3059, 3936, 1927, 2052, 4404, 3]}, "items": [{"id": "p_3453", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_3454", "content": "agitation [SEP]  consists of shivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. The most common cause of this syndrome is an ", "tokenized_content": [2, 18389, 3, 7543, 1927, 20837, 2004, 1941, 16, 3760, 20471, 16, 12999, 1929, 16, 18272, 16, 18389, 1930, 21945, 18, 1920, 2501, 3059, 3936, 1927, 2052, 4741, 1977, 1925, 3]}, "items": [{"id": "p_3454", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_3455", "content": "hyperthermia [SEP] hivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. The most common cause of this syndrome is an interaction betwe", "tokenized_content": [2, 21945, 3, 3525, 6417, 16, 3760, 20471, 16, 12999, 1929, 16, 18272, 16, 18389, 1930, 21945, 18, 1920, 2501, 3059, 3936, 1927, 2052, 4741, 1977, 1925, 2835, 2143, 2172, 3]}, "items": [{"id": "p_3455", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_3456", "content": "Venlafaxine [SEP] e inhibitor (MAOI) and a specific serotonin reuptake inhibitor. Venlafaxine is a new antidepressant agent that inhibits the reuptake of ser", "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 47, 4106, 12, 21178, 1033, 13, 1930, 43, 2487, 11153, 22957, 4106, 18, 8102, 5148, 6016, 25204, 1977, 43, 2814, 14183, 5899, 1988, 7042, 1920, 3]}, "items": [{"id": "p_3456", "content": "venlafaxine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 3]}]}
{"query": {"id": "q_3457", "content": "norepinephrine [SEP] ntidepressant agent that inhibits the reuptake of serotonin and norepinephrine. We report a venlafaxine-MAOI interaction that resulted in the ", "tokenized_content": [2, 16436, 3, 5891, 2261, 2109, 2031, 5899, 1988, 7042, 1920, 22957, 1927, 11153, 1930, 16436, 18, 2038, 3809, 43, 8102, 5148, 6016, 25204, 17, 21178, 1033, 2835, 1988, 4306, 1922, 3]}, "items": [{"id": "p_3457", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_3458", "content": "venlafaxine [SEP] ibits the reuptake of serotonin and norepinephrine. We report a venlafaxine-MAOI interaction that resulted in the serotonin syndrome in a 2", "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 6180, 2664, 1920, 22957, 1927, 11153, 1930, 16436, 18, 2038, 3809, 43, 8102, 5148, 6016, 25204, 17, 21178, 1033, 2835, 1988, 4306, 1922, 1920, 11153, 3]}, "items": [{"id": "p_3458", "content": "venlafaxine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 3]}]}
{"query": {"id": "q_3459", "content": "serotonin syndrome [SEP] . We report a venlafaxine-MAOI interaction that resulted in the serotonin syndrome in a 23-y-old male who was taking tranylcypromine for depressio", "tokenized_content": [2, 11153, 4741, 3, 18, 2038, 3809, 43, 8102, 5148, 6016, 25204, 17, 21178, 1033, 2835, 1988, 4306, 1922, 1920, 11153, 4741, 1922, 43, 3020, 17, 67, 17, 4156, 4005, 2746, 3]}, "items": [{"id": "p_3459", "content": "Serotonin Syndrome [SEP] An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It i", "score": 1, "type": null, "tokenized_content": [2, 11153, 4741, 3, 1925, 5246, 2838, 2835, 4378, 2007, 5520, 5018, 3642, 16, 13725, 5273, 16, 1930, 15829, 6754, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3460", "content": "tranylcypromine [SEP] ted in the serotonin syndrome in a 23-y-old male who was taking tranylcypromine for depression. He had been well until the morning of presentat", "tokenized_content": [2, 29808, 2199, 13796, 2216, 25157, 3, 26080, 1922, 1920, 11153, 4741, 1922, 43, 3020, 17, 67, 17, 4156, 4005, 2746, 1982, 6303, 29808, 2199, 13796, 2216, 25157, 1958, 4621, 18, 3]}, "items": [{"id": "p_3460", "content": "Tranylcypromine [SEP] A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the", "score": 1, "type": null, "tokenized_content": [2, 29808, 2199, 13796, 2216, 25157, 3, 43, 20299, 3812, 5333, 2037, 1920, 25267, 1927, 1920, 4159, 4659, 1927, 19057, 18, 2052, 25368, 10488, 4106, 1977, 3655, 1922, 1920, 3]}]}
{"query": {"id": "q_3461", "content": "depression [SEP]  syndrome in a 23-y-old male who was taking tranylcypromine for depression. He had been well until the morning of presentation when he too", "tokenized_content": [2, 4621, 3, 4741, 1922, 43, 3020, 17, 67, 17, 4156, 4005, 2746, 1982, 6303, 29808, 2199, 13796, 2216, 25157, 1958, 4621, 18, 2234, 2430, 2252, 2486, 4801, 1920, 12661, 1927, 3]}, "items": [{"id": "p_3461", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_3462", "content": "tremors [SEP] h he became confused with jerking movements of his extremities, tremors and rigidity. He was brought directly to a hospital where he wa", "tokenized_content": [2, 18388, 1036, 3, 50, 2234, 7935, 30190, 1956, 26482, 18046, 8264, 1927, 4167, 18884, 16, 18388, 1036, 1930, 20471, 18, 2234, 1982, 13581, 4103, 1942, 43, 3461, 2597, 2234, 4114, 3]}, "items": [{"id": "p_3462", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_3463", "content": "rigidity [SEP] syndrome of serotonin excess that consists of shivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. The most co", "tokenized_content": [2, 20471, 3, 4741, 1927, 11153, 5799, 1988, 7543, 1927, 20837, 2004, 1941, 16, 3760, 20471, 16, 12999, 1929, 16, 18272, 16, 18389, 1930, 21945, 18, 1920, 2501, 2081, 3]}, "items": [{"id": "p_3463", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_3464", "content": "myoclonic jerks [SEP]  where he was found to be agitated and confused with shivering, myoclonic jerks, rigidity, salivation and diaphoresis. His pupils were 7 mm and", "tokenized_content": [2, 15924, 2223, 3490, 26482, 5297, 3, 2597, 2234, 1982, 2435, 1942, 1998, 2260, 19633, 1930, 30190, 1956, 20837, 2004, 1941, 16, 15924, 2223, 3490, 26482, 5297, 16, 20471, 16, 12999, 3]}, "items": [{"id": "p_3464", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_3465", "content": "diazepam [SEP]  respiratory rate 28/min, and temperature 97 F. After 180 mg of diazepam i.v. he remained tremulous with muscle rigidity and clenched ja", "tokenized_content": [2, 26079, 3, 5481, 2769, 3158, 19, 2360, 16, 1930, 3449, 5749, 48, 18, 2256, 8585, 2786, 1927, 26079, 51, 18, 64, 18, 2234, 5410, 11797, 17918, 1956, 3760, 20471, 1930, 3]}, "items": [{"id": "p_3465", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_3466", "content": "hypoventilation [SEP] hed jaws. He was intubated for airway protection and because of hypoventilation, and was paralyzed to control muscle rigidity. His subsequent c", "tokenized_content": [2, 14395, 5954, 29526, 3, 13794, 16795, 1036, 18, 2234, 1982, 16079, 7972, 2013, 1958, 8155, 6202, 1930, 2882, 1927, 14395, 5954, 29526, 16, 1930, 1982, 11271, 16273, 1942, 2285, 3760, 3]}, "items": [{"id": "p_3466", "content": "Hypoventilation [SEP] A reduction in the amount of air entering the pulmonary alveoli.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14395, 5954, 29526, 3, 43, 3378, 1922, 1920, 4351, 1927, 4433, 14657, 1920, 5352, 23405, 8436, 18, 3]}]}
{"query": {"id": "q_3467", "content": "paralyzed [SEP] d for airway protection and because of hypoventilation, and was paralyzed to control muscle rigidity. His subsequent course was remarkabl", "tokenized_content": [2, 11271, 16273, 3, 46, 1958, 8155, 6202, 1930, 2882, 1927, 14395, 5954, 29526, 16, 1930, 1982, 11271, 16273, 1942, 2285, 3760, 20471, 18, 4167, 4521, 4914, 1982, 7688, 18613, 3]}, "items": [{"id": "p_3467", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_3468", "content": "thrombocytopenia [SEP] e rigidity. His subsequent course was remarkable for non-immune thrombocytopenia which resolved. The patient's maximal temperature was 101.2 F a", "tokenized_content": [2, 17100, 3, 47, 20471, 18, 4167, 4521, 4914, 1982, 11293, 1958, 2447, 17, 3743, 17100, 2154, 8397, 18, 1920, 2774, 11, 61, 7275, 3449, 1982, 9447, 18, 22, 48, 43, 3]}, "items": [{"id": "p_3468", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3469", "content": "rhabdomyolysis [SEP]  F and his CPK remained < 500 units/L with no other evidence of rhabdomyolysis. His mental status normalized and he was transferred to a psych", "tokenized_content": [2, 25369, 6892, 3, 48, 1930, 4167, 4244, 1040, 5410, 32, 4599, 5701, 19, 54, 1956, 2239, 2303, 3095, 1927, 25369, 6892, 18, 4167, 5018, 3642, 5766, 1930, 2234, 1982, 6311, 3]}, "items": [{"id": "p_3469", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_3470", "content": "paralysis [SEP] thout sequelae due to the aggressive sedation and neuromuscular paralysis.", "tokenized_content": [2, 18973, 3, 1913, 2382, 19067, 2810, 1942, 1920, 8704, 15263, 1930, 15829, 18973, 18, 3]}, "items": [{"id": "p_3470", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_3471", "content": "L-dopa [SEP] Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys.", "tokenized_content": [2, 54, 17, 19428, 3, 2495, 1927, 13125, 8228, 25157, 1005, 11545, 4195, 1990, 54, 17, 19428, 17, 2719, 3890, 26682, 1036, 1922, 19043, 17, 2868, 11909, 18, 3]}, "items": [{"id": "p_3471", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3472", "content": "dyskinesias [SEP] Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys.", "tokenized_content": [2, 3890, 26682, 1036, 3, 2495, 1927, 13125, 8228, 25157, 1005, 11545, 4195, 1990, 54, 17, 19428, 17, 2719, 3890, 26682, 1036, 1922, 19043, 17, 2868, 11909, 18, 3]}, "items": [{"id": "p_3472", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3473", "content": "MPTP [SEP] ffect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys.", "tokenized_content": [2, 19043, 3, 10735, 2089, 1927, 13125, 8228, 25157, 1005, 11545, 4195, 1990, 54, 17, 19428, 17, 2719, 3890, 26682, 1036, 1922, 19043, 17, 2868, 11909, 18, 3]}, "items": [{"id": "p_3473", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_3474", "content": "parkinsonian [SEP] A group of four monkeys was rendered parkinsonian with the toxin MPTP. They were then treated chronically with L-", "tokenized_content": [2, 10124, 3122, 3, 43, 2210, 1927, 3006, 11909, 1982, 18416, 10124, 3122, 1956, 1920, 9165, 19043, 18, 2611, 1985, 2759, 2868, 16132, 1956, 54, 17, 3]}, "items": [{"id": "p_3474", "content": "Parkinsonian Disorders [SEP] A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural i", "score": 1, "type": null, "tokenized_content": [2, 10124, 3122, 4414, 3, 43, 2210, 1927, 4414, 2154, 5961, 5761, 4842, 2285, 4378, 2007, 20152, 26682, 16, 3760, 20471, 31, 18388, 31, 1930, 17198, 51, 3]}]}
{"query": {"id": "q_3475", "content": "MPTP [SEP]  group of four monkeys was rendered parkinsonian with the toxin MPTP. They were then treated chronically with L-DOPA/benserazide 50/", "tokenized_content": [2, 19043, 3, 2210, 1927, 3006, 11909, 1982, 18416, 10124, 3122, 1956, 1920, 9165, 19043, 18, 2611, 1985, 2759, 2868, 16132, 1956, 54, 17, 19428, 19, 7129, 13545, 29895, 2761, 19, 3]}, "items": [{"id": "p_3475", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_3476", "content": "L-DOPA/benserazide [SEP] an with the toxin MPTP. They were then treated chronically with L-DOPA/benserazide 50/12.5 mg/kg given orally daily for 2 months. This dose produc", "tokenized_content": [2, 54, 17, 19428, 19, 7129, 13545, 29895, 3, 1925, 1956, 1920, 9165, 19043, 18, 2611, 1985, 2759, 2868, 16132, 1956, 54, 17, 19428, 19, 7129, 13545, 29895, 2761, 19, 2369, 3]}, "items": [{"id": "p_3476", "content": "benserazide, levodopa drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7129, 13545, 29895, 16, 26723, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_3477", "content": "dyskinesia [SEP]  a striking antiparkinsonian effect, but all animals manifested dyskinesia. A series of agents acting primarily on neurotransmitters other", "tokenized_content": [2, 3890, 26682, 3, 43, 9784, 24290, 14488, 6114, 1022, 2495, 16, 2308, 2136, 3555, 16687, 3890, 26682, 18, 43, 4696, 1927, 4820, 8290, 5985, 1990, 21012, 2303, 3]}, "items": [{"id": "p_3477", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3478", "content": "dopamine [SEP] ries of agents acting primarily on neurotransmitters other than dopamine were then tested in combination with L-DOPA to see if the dyski", "tokenized_content": [2, 7964, 3, 11280, 1918, 1927, 4820, 8290, 5985, 1990, 21012, 2303, 2254, 7964, 1985, 2759, 3620, 1922, 3921, 1956, 54, 17, 19428, 1942, 3365, 2647, 1920, 3890, 7369, 3]}, "items": [{"id": "p_3478", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3479", "content": "L-DOPA [SEP] an with the toxin MPTP. They were then treated chronically with L-DOPA/benserazide 50/12.5 mg/kg given orally daily for 2 months. This", "tokenized_content": [2, 54, 17, 19428, 3, 1925, 1956, 1920, 9165, 19043, 18, 2611, 1985, 2759, 2868, 16132, 1956, 54, 17, 19428, 19, 7129, 13545, 29895, 2761, 19, 2369, 18, 25, 2786, 19, 3]}, "items": [{"id": "p_3479", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3480", "content": "dyskinetic [SEP] amine were then tested in combination with L-DOPA to see if the dyskinetic movements would be modified. Several drugs, including clonidine", "tokenized_content": [2, 3890, 24590, 2002, 3, 13610, 1985, 2759, 3620, 1922, 3921, 1956, 54, 17, 19428, 1942, 3365, 2647, 1920, 3890, 24590, 2002, 8264, 2962, 1998, 4795, 18, 2980, 4195, 16, 2710, 3]}, "items": [{"id": "p_3480", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3481", "content": "clonidine [SEP] yskinetic movements would be modified. Several drugs, including clonidine, physostigmine, methysergide, 5-MDOT, propranolol, and MK-801, ", "tokenized_content": [2, 26596, 3, 24018, 24590, 2002, 8264, 2962, 1998, 4795, 18, 2980, 4195, 16, 2710, 26596, 16, 2861, 2259, 29043, 2053, 16, 2295, 2012, 2693, 2261, 16, 25, 17, 4445, 1991, 3]}, "items": [{"id": "p_3481", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_3482", "content": "physostigmine [SEP] ovements would be modified. Several drugs, including clonidine, physostigmine, methysergide, 5-MDOT, propranolol, and MK-801, markedly reduce", "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 4285, 6845, 2962, 1998, 4795, 18, 2980, 4195, 16, 2710, 26596, 16, 2861, 2259, 29043, 2053, 16, 2295, 2012, 2693, 2261, 16, 25, 17, 4445, 3]}, "items": [{"id": "p_3482", "content": "Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c", "score": 1, "type": null, "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 6221, 14504, 2596, 5726, 18, 2176, 2112, 1998, 3730, 12259, 1954, 1942, 1920, 16911, 1019, 18, 2176, 2222, 45, 3]}]}
{"query": {"id": "q_3483", "content": "methysergide [SEP] be modified. Several drugs, including clonidine, physostigmine, methysergide, 5-MDOT, propranolol, and MK-801, markedly reduced the dyskinet", "tokenized_content": [2, 2295, 2012, 2693, 2261, 3, 1998, 4795, 18, 2980, 4195, 16, 2710, 26596, 16, 2861, 2259, 29043, 2053, 16, 2295, 2012, 2693, 2261, 16, 25, 17, 4445, 1991, 16, 21395, 3]}, "items": [{"id": "p_3483", "content": "Methysergide [SEP] An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels a", "score": 1, "type": null, "tokenized_content": [2, 2295, 2012, 2693, 2261, 3, 1925, 11949, 1991, 10533, 1988, 1977, 43, 8680, 1915, 1927, 3629, 5237, 2687, 18622, 5482, 18, 2176, 28104, 1036, 1920, 2564, 1927, 11153, 1922, 2877, 7208, 43, 3]}]}
{"query": {"id": "q_3484", "content": "propranolol [SEP] rugs, including clonidine, physostigmine, methysergide, 5-MDOT, propranolol, and MK-801, markedly reduced the dyskinetic movements but at t", "tokenized_content": [2, 21395, 3, 23148, 1036, 16, 2710, 26596, 16, 2861, 2259, 29043, 2053, 16, 2295, 2012, 2693, 2261, 16, 25, 17, 4445, 1991, 16, 21395, 16, 1930, 10539, 17, 23858, 16, 3]}, "items": [{"id": "p_3484", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_3485", "content": "MK-801 [SEP] lonidine, physostigmine, methysergide, 5-MDOT, propranolol, and MK-801, markedly reduced the dyskinetic movements but at the cost of a", "tokenized_content": [2, 10539, 17, 23858, 3, 10969, 5802, 16, 2861, 2259, 29043, 2053, 16, 2295, 2012, 2693, 2261, 16, 25, 17, 4445, 1991, 16, 21395, 16, 1930, 10539, 17, 23858, 16, 7686, 3]}, "items": [{"id": "p_3485", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_3486", "content": "yohimbine [SEP] t the cost of a return of parkinsonian symptomatology. However, yohimbine and meperidine reduced predominantly the dyskinetic movements. ", "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 62, 1920, 4455, 1927, 43, 7215, 1927, 10124, 3122, 21015, 18, 2406, 16, 7419, 7969, 17010, 2053, 1930, 17257, 18842, 27099, 3028, 7700, 1920, 3890, 3]}, "items": [{"id": "p_3486", "content": "Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT", "score": 1, "type": null, "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 43, 4496, 29951, 1956, 4595, 17, 22, 17, 13672, 7472, 2455, 18, 7419, 7969, 17010, 2053, 2258, 2252, 2251, 1966, 43, 15388, 3027, 2479, 1930, 1922, 1920, 2311, 1927, 24311, 1031, 3]}]}
{"query": {"id": "q_3487", "content": "meperidine [SEP] a return of parkinsonian symptomatology. However, yohimbine and meperidine reduced predominantly the dyskinetic movements. Baclofen was al", "tokenized_content": [2, 17257, 18842, 27099, 3, 43, 7215, 1927, 10124, 3122, 21015, 18, 2406, 16, 7419, 7969, 17010, 2053, 1930, 17257, 18842, 27099, 3028, 7700, 1920, 3890, 24590, 2002, 8264, 18, 30491, 3]}, "items": [{"id": "p_3487", "content": "Meperidine [SEP] A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and ", "score": 1, "type": null, "tokenized_content": [2, 17257, 18842, 27099, 3, 43, 22872, 3153, 14501, 1988, 2112, 1998, 2251, 1958, 1920, 13104, 1927, 2501, 3584, 1927, 5086, 1942, 4010, 3594, 16, 2710, 5924, 3594, 1930, 3]}]}
{"query": {"id": "q_3488", "content": "Baclofen [SEP]  and meperidine reduced predominantly the dyskinetic movements. Baclofen was also useful in one monkey against a more dystonic form of d", "tokenized_content": [2, 30491, 18514, 3, 1930, 17257, 18842, 27099, 3028, 7700, 1920, 3890, 24590, 2002, 8264, 18, 30491, 18514, 1982, 2222, 4707, 1922, 2340, 14055, 3316, 43, 2253, 10612, 3490, 2386, 1927, 3]}, "items": [{"id": "p_3488", "content": "Baclofen [SEP] A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPAST", "score": 1, "type": null, "tokenized_content": [2, 30491, 18514, 3, 43, 7034, 17, 29093, 2687, 10533, 1988, 1977, 43, 2487, 7829, 1927, 7992, 17, 44, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3760, 19361, 2156, 3]}]}
{"query": {"id": "q_3489", "content": "dystonic [SEP] ovements. Baclofen was also useful in one monkey against a more dystonic form of dyskinesia. Atropine converted the dystonic movements i", "tokenized_content": [2, 10612, 3490, 3, 4285, 6845, 18, 30491, 18514, 1982, 2222, 4707, 1922, 2340, 14055, 3316, 43, 2253, 10612, 3490, 2386, 1927, 3890, 26682, 18, 24031, 9076, 1920, 10612, 3490, 8264, 3]}, "items": [{"id": "p_3489", "content": "Dystonic Disorders [SEP] Acquired and inherited conditions that feature DYSTONIA as a primary manifestation of disease. These disorders are generally div", "score": 1, "type": null, "tokenized_content": [2, 10612, 3490, 4414, 3, 5815, 1930, 12911, 2961, 1988, 5961, 23357, 1966, 43, 3065, 15570, 1927, 2573, 18, 2144, 4414, 2032, 4933, 6421, 3]}]}
{"query": {"id": "q_3490", "content": "Atropine [SEP] seful in one monkey against a more dystonic form of dyskinesia. Atropine converted the dystonic movements into chorea.", "tokenized_content": [2, 24031, 3, 2058, 2903, 1922, 2340, 14055, 3316, 43, 2253, 10612, 3490, 2386, 1927, 3890, 26682, 18, 24031, 9076, 1920, 10612, 3490, 8264, 2460, 11418, 5376, 18, 3]}, "items": [{"id": "p_3490", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_3491", "content": "chorea [SEP] m of dyskinesia. Atropine converted the dystonic movements into chorea.", "tokenized_content": [2, 11418, 5376, 3, 55, 1927, 3890, 26682, 18, 24031, 9076, 1920, 10612, 3490, 8264, 2460, 11418, 5376, 18, 3]}, "items": [{"id": "p_3491", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_3492", "content": "CCNU [SEP] CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07).", "tokenized_content": [2, 21040, 1032, 3, 21040, 1032, 12, 3004, 23084, 4425, 13, 5532, 1922, 7894, 30, 43, 6968, 2161, 12, 4631, 17, 6627, 13, 18, 3]}, "items": [{"id": "p_3492", "content": "Lomustine [SEP] An alkylating agent of value against both hematologic malignancies and solid tumors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3004, 23084, 4425, 3, 1925, 28912, 5899, 1927, 3113, 3316, 2321, 18251, 10672, 1930, 5358, 3861, 18, 3]}]}
{"query": {"id": "q_3493", "content": "lomustine [SEP] CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07).", "tokenized_content": [2, 3004, 23084, 4425, 3, 21040, 1032, 12, 3004, 23084, 4425, 13, 5532, 1922, 7894, 30, 43, 6968, 2161, 12, 4631, 17, 6627, 13, 18, 3]}, "items": [{"id": "p_3493", "content": "Lomustine [SEP] An alkylating agent of value against both hematologic malignancies and solid tumors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3004, 23084, 4425, 3, 1925, 28912, 5899, 1927, 3113, 3316, 2321, 18251, 10672, 1930, 5358, 3861, 18, 3]}]}
{"query": {"id": "q_3494", "content": "toxicity [SEP] CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07).", "tokenized_content": [2, 5532, 3, 21040, 1032, 12, 3004, 23084, 4425, 13, 5532, 1922, 7894, 30, 43, 6968, 2161, 12, 4631, 17, 6627, 13, 18, 3]}, "items": [{"id": "p_3494", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3495", "content": "gastrointestinal toxicities [SEP] To describe the incidence of haematological, renal, hepatic and gastrointestinal toxicities in tumour-bearing dogs receiving 1-(2-chloroethyl)-3-cyclohexyl", "tokenized_content": [2, 8375, 15251, 3, 1942, 5993, 1920, 4332, 1927, 28691, 16, 4604, 16, 6095, 1930, 8375, 15251, 1922, 6383, 17, 8188, 7894, 5962, 21, 17, 12, 22, 17, 10107, 5188, 13, 3]}, "items": [{"id": "p_3495", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_3496", "content": "1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea [SEP] nd gastrointestinal toxicities in tumour-bearing dogs receiving 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). DESIGN: The medical records of 206 dogs that were treat", "tokenized_content": [2, 21, 17, 12, 22, 17, 10107, 5188, 13, 17, 23, 17, 22724, 2199, 17, 21, 17, 16665, 2257, 5376, 3, 8026, 8375, 15251, 1922, 6383, 17, 8188, 7894, 5962, 21, 3]}, "items": [{"id": "p_3496", "content": "Lomustine [SEP] An alkylating agent of value against both hematologic malignancies and solid tumors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3004, 23084, 4425, 3, 1925, 28912, 5899, 1927, 3113, 3316, 2321, 18251, 10672, 1930, 5358, 3861, 18, 3]}]}
{"query": {"id": "q_3497", "content": "CCNU [SEP] ng dogs receiving 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). DESIGN: The medical records of 206 dogs that were treated wit", "tokenized_content": [2, 21040, 1032, 3, 4375, 7894, 5962, 21, 17, 12, 22, 17, 10107, 5188, 13, 17, 23, 17, 22724, 2199, 17, 21, 17, 16665, 2257, 5376, 12, 21040, 1032, 13, 18, 3]}, "items": [{"id": "p_3497", "content": "Lomustine [SEP] An alkylating agent of value against both hematologic malignancies and solid tumors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3004, 23084, 4425, 3, 1925, 28912, 5899, 1927, 3113, 3316, 2321, 18251, 10672, 1930, 5358, 3861, 18, 3]}]}
{"query": {"id": "q_3498", "content": "toxicity [SEP]  CCNU, 185 met the inclusion criteria for at least one class of toxicity. CCNU was used most commonly in the treatment of lymphoma, mast", "tokenized_content": [2, 5532, 3, 21040, 1032, 16, 15659, 2130, 1920, 6125, 4164, 1958, 2019, 3464, 2340, 2921, 1927, 5532, 18, 21040, 1032, 1982, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 8636, 16, 3]}, "items": [{"id": "p_3498", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3499", "content": "lymphoma [SEP] ss of toxicity. CCNU was used most commonly in the treatment of lymphoma, mast cell tumour, brain tumour, histiocytic tumours and epithe", "tokenized_content": [2, 8636, 3, 4577, 1927, 5532, 18, 21040, 1032, 1982, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 8636, 16, 9731, 2024, 6383, 16, 3068, 6383, 16, 27507, 8316, 9313, 1930, 4240, 3]}, "items": [{"id": "p_3499", "content": "Lymphoma [SEP] A general term for various neoplastic diseases of the lymphoid tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8636, 3, 43, 3335, 2576, 1958, 3425, 12847, 3902, 1927, 1920, 11751, 2960, 18, 3]}]}
{"query": {"id": "q_3500", "content": "mast cell tumour [SEP] city. CCNU was used most commonly in the treatment of lymphoma, mast cell tumour, brain tumour, histiocytic tumours and epitheliotropic lymphoma", "tokenized_content": [2, 9731, 2024, 6383, 3, 8318, 18, 21040, 1032, 1982, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 8636, 16, 9731, 2024, 6383, 16, 3068, 6383, 16, 27507, 8316, 9313, 1930, 30001, 3]}, "items": [{"id": "p_3500", "content": "Mastocytoma [SEP] A solid tumor consisting of a dense infiltration of MAST CELLS. It is generally benign.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9731, 26493, 3, 43, 5358, 2798, 7600, 1927, 43, 10472, 8946, 1927, 9731, 2094, 18, 2176, 1977, 4933, 8867, 18, 3]}]}
{"query": {"id": "q_3501", "content": "brain tumour [SEP] d most commonly in the treatment of lymphoma, mast cell tumour, brain tumour, histiocytic tumours and epitheliotropic lymphoma. Throughout t", "tokenized_content": [2, 3068, 6383, 3, 46, 2501, 5384, 1922, 1920, 2311, 1927, 8636, 16, 9731, 2024, 6383, 16, 3068, 6383, 16, 27507, 8316, 9313, 1930, 30001, 8405, 8636, 18, 5264, 62, 3]}, "items": [{"id": "p_3501", "content": "Brain Neoplasms [SEP] Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypot", "score": 1, "type": null, "tokenized_content": [2, 3068, 15347, 3, 15347, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 16, 2710, 1920, 6329, 21098, 16, 5342, 13086, 16, 12201, 3]}]}
{"query": {"id": "q_3502", "content": "histiocytic tumours [SEP] y in the treatment of lymphoma, mast cell tumour, brain tumour, histiocytic tumours and epitheliotropic lymphoma. Throughout treatment, 56.9% of do", "tokenized_content": [2, 27507, 8316, 9313, 3, 67, 1922, 1920, 2311, 1927, 8636, 16, 9731, 2024, 6383, 16, 3068, 6383, 16, 27507, 8316, 9313, 1930, 30001, 8405, 8636, 18, 5264, 2311, 16, 4489, 3]}, "items": [{"id": "p_3502", "content": "Histiocytic Disorders, Malignant [SEP] Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27507, 8316, 4414, 16, 6558, 3, 15308, 12847, 4414, 1927, 27507, 3443, 18, 3063, 2032, 6558, 15347, 1927, 5205, 1930, 8104, 2094, 18, 3]}]}
{"query": {"id": "q_3503", "content": "epitheliotropic lymphoma [SEP] mphoma, mast cell tumour, brain tumour, histiocytic tumours and epitheliotropic lymphoma. Throughout treatment, 56.9% of dogs experienced neutropenia, 3", "tokenized_content": [2, 30001, 8405, 8636, 3, 20623, 2954, 16, 9731, 2024, 6383, 16, 3068, 6383, 16, 27507, 8316, 9313, 1930, 30001, 8405, 8636, 18, 5264, 2311, 16, 4489, 18, 29, 9, 1927, 3]}, "items": [{"id": "p_3503", "content": "Lymphoma [SEP] A general term for various neoplastic diseases of the lymphoid tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8636, 3, 43, 3335, 2576, 1958, 3425, 12847, 3902, 1927, 1920, 11751, 2960, 18, 3]}]}
{"query": {"id": "q_3504", "content": "neutropenia [SEP] ropic lymphoma. Throughout treatment, 56.9% of dogs experienced neutropenia, 34.2% experienced anaemia and 14.2% experienced thrombocytopen", "tokenized_content": [2, 18005, 3, 17890, 1935, 8636, 18, 5264, 2311, 16, 4489, 18, 29, 9, 1927, 7894, 6090, 18005, 16, 3540, 18, 22, 9, 6090, 19682, 1930, 2607, 18, 22, 9, 6090, 3]}, "items": [{"id": "p_3504", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3505", "content": "anaemia [SEP] tment, 56.9% of dogs experienced neutropenia, 34.2% experienced anaemia and 14.2% experienced thrombocytopenia. Gastrointestinal toxico", "tokenized_content": [2, 19682, 3, 22377, 4905, 16, 4489, 18, 29, 9, 1927, 7894, 6090, 18005, 16, 3540, 18, 22, 9, 6090, 19682, 1930, 2607, 18, 22, 9, 6090, 17100, 18, 8375, 6161, 3]}, "items": [{"id": "p_3505", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3506", "content": "thrombocytopenia [SEP] ed neutropenia, 34.2% experienced anaemia and 14.2% experienced thrombocytopenia. Gastrointestinal toxicosis was detected in 37.8% of dogs, the ", "tokenized_content": [2, 17100, 3, 3347, 18005, 16, 3540, 18, 22, 9, 6090, 19682, 1930, 2607, 18, 22, 9, 6090, 17100, 18, 8375, 6161, 2475, 1982, 3330, 1922, 3191, 18, 28, 9, 1927, 3]}, "items": [{"id": "p_3506", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3507", "content": "Gastrointestinal toxicosis [SEP] .2% experienced anaemia and 14.2% experienced thrombocytopenia. Gastrointestinal toxicosis was detected in 37.8% of dogs, the most common sign of which wa", "tokenized_content": [2, 8375, 6161, 2475, 3, 18, 22, 9, 6090, 19682, 1930, 2607, 18, 22, 9, 6090, 17100, 18, 8375, 6161, 2475, 1982, 3330, 1922, 3191, 18, 28, 9, 1927, 7894, 16, 3]}, "items": [{"id": "p_3507", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_3508", "content": "vomiting [SEP] as detected in 37.8% of dogs, the most common sign of which was vomiting (24.3%). Potential renal toxicity and elevated alanine transami", "tokenized_content": [2, 13954, 3, 1966, 3330, 1922, 3191, 18, 28, 9, 1927, 7894, 16, 1920, 2501, 3059, 2105, 1927, 2154, 1982, 13954, 12, 2686, 18, 23, 9, 13, 18, 2889, 4604, 5532, 3]}, "items": [{"id": "p_3508", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_3509", "content": "alanine [SEP] ich was vomiting (24.3%). Potential renal toxicity and elevated alanine transaminase (ALT) concentration were reported in 12.2% and 48.", "tokenized_content": [2, 10504, 3, 14910, 1982, 13954, 12, 2686, 18, 23, 9, 13, 18, 2889, 4604, 5532, 1930, 4664, 10504, 24376, 12, 8387, 13, 3110, 1985, 2568, 1922, 2369, 18, 22, 9, 3]}, "items": [{"id": "p_3509", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_3510", "content": "hepatic failure [SEP] rted in 12.2% and 48.8% of dogs, respectively. The incidence of hepatic failure was 1.2%. CONCLUSIONS: CCNU-associated toxicity in dogs is comm", "tokenized_content": [2, 6095, 4574, 3, 4341, 1919, 1922, 2369, 18, 22, 9, 1930, 3427, 18, 28, 9, 1927, 7894, 16, 2763, 18, 1920, 4332, 1927, 6095, 4574, 1982, 21, 18, 22, 9, 3]}, "items": [{"id": "p_3510", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_3511", "content": "steroids [SEP] Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic sei", "tokenized_content": [2, 13039, 3, 3366, 3849, 13039, 9145, 3316, 7547, 7095, 12184, 17, 1930, 24714, 1935, 2687, 17, 2719, 20590, 2058, 1033, 3]}, "items": [{"id": "p_3511", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3512", "content": "pilocarpine [SEP] Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus", "tokenized_content": [2, 7547, 7095, 12184, 3, 3366, 3849, 13039, 9145, 3316, 7547, 7095, 12184, 17, 1930, 24714, 1935, 2687, 17, 2719, 20590, 10060, 1930, 3642, 16304, 1957, 3]}, "items": [{"id": "p_3512", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_3513", "content": "kainic acid [SEP] Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.", "tokenized_content": [2, 24714, 1935, 2687, 3, 3366, 3849, 13039, 9145, 3316, 7547, 7095, 12184, 17, 1930, 24714, 1935, 2687, 17, 2719, 20590, 10060, 1930, 3642, 16304, 1957, 1922, 2518, 18, 3]}, "items": [{"id": "p_3513", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_3514", "content": "seizures [SEP] ids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.", "tokenized_content": [2, 10060, 3, 20727, 9145, 3316, 7547, 7095, 12184, 17, 1930, 24714, 1935, 2687, 17, 2719, 20590, 10060, 1930, 3642, 16304, 1957, 1922, 2518, 18, 3]}, "items": [{"id": "p_3514", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3515", "content": "status epilepticus [SEP] gainst pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.", "tokenized_content": [2, 3642, 16304, 1957, 3, 13241, 1031, 7547, 7095, 12184, 17, 1930, 24714, 1935, 2687, 17, 2719, 20590, 10060, 1930, 3642, 16304, 1957, 1922, 2518, 18, 3]}, "items": [{"id": "p_3515", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_3516", "content": "progesterone [SEP] Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 a", "tokenized_content": [2, 11528, 3, 2980, 12171, 2712, 6926, 1927, 11528, 12, 23, 4595, 17, 8275, 4297, 2516, 17, 2036, 17, 8067, 13, 1930, 16333, 4879, 7446, 5670, 2156, 6506, 2912, 12, 23, 3]}, "items": [{"id": "p_3516", "content": "Progesterone [SEP] The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTER", "score": 1, "type": null, "tokenized_content": [2, 11528, 3, 1920, 3044, 10759, 4926, 1923, 9507, 1988, 1977, 8366, 5985, 2007, 1920, 13776, 12867, 1989, 1930, 1920, 13752, 18, 11528, 8016, 1990, 1920, 8123, 3]}]}
{"query": {"id": "q_3517", "content": "3 alpha-hydroxy pregnane-20-ones [SEP] Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-o", "tokenized_content": [2, 23, 4595, 17, 8275, 4297, 2516, 17, 2036, 17, 8067, 3, 2980, 12171, 2712, 6926, 1927, 11528, 12, 23, 4595, 17, 8275, 4297, 2516, 17, 2036, 17, 8067, 13, 1930, 3]}, "items": [{"id": "p_3517", "content": "Progesterone [SEP] The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTER", "score": 1, "type": null, "tokenized_content": [2, 11528, 3, 1920, 3044, 10759, 4926, 1923, 9507, 1988, 1977, 8366, 5985, 2007, 1920, 13776, 12867, 1989, 1930, 1920, 13752, 18, 11528, 8016, 1990, 1920, 8123, 3]}]}
{"query": {"id": "q_3518", "content": "deoxycorticosterone [SEP] abolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epi", "tokenized_content": [2, 16333, 4879, 7446, 5670, 2156, 6506, 2912, 3, 9308, 2923, 1927, 11528, 12, 23, 4595, 17, 8275, 4297, 2516, 17, 2036, 17, 8067, 13, 1930, 16333, 4879, 7446, 5670, 2156, 3]}, "items": [{"id": "p_3518", "content": "Desoxycorticosterone [SEP] A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE\n    ", "score": 1, "type": null, "tokenized_content": [2, 2270, 7221, 4879, 7446, 5670, 2156, 6506, 2912, 3, 43, 9507, 9483, 1988, 1977, 1920, 2513, 17, 16333, 10533, 1927, 18136, 1930, 1920, 2900, 17, 8275, 10533, 1927, 11528, 3]}]}
{"query": {"id": "q_3519", "content": "3 alpha-hydroxy pregnane-21-diol-20-ones [SEP] one (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activit", "tokenized_content": [2, 23, 4595, 17, 8275, 4297, 2516, 17, 2900, 17, 28208, 17, 2036, 17, 8067, 3, 2340, 12, 23, 4595, 17, 8275, 4297, 2516, 17, 2036, 17, 8067, 13, 1930, 16333, 3]}, "items": [{"id": "p_3519", "content": "Desoxycorticosterone [SEP] A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE\n    ", "score": 1, "type": null, "tokenized_content": [2, 2270, 7221, 4879, 7446, 5670, 2156, 6506, 2912, 3, 43, 9507, 9483, 1988, 1977, 1920, 2513, 17, 16333, 10533, 1927, 18136, 1930, 1920, 2900, 17, 8275, 10533, 1927, 11528, 3]}]}
{"query": {"id": "q_3520", "content": "pilocarpine [SEP] r 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures", "tokenized_content": [2, 7547, 7095, 12184, 3, 60, 23, 4666, 17, 13872, 27306, 1985, 3747, 1958, 6337, 2455, 3316, 7547, 7095, 12184, 17, 16, 24714, 1935, 2687, 17, 1930, 56, 17, 4963, 17, 3]}, "items": [{"id": "p_3520", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_3521", "content": "kainic acid [SEP] rs were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Ster", "tokenized_content": [2, 24714, 1935, 2687, 3, 4366, 1985, 3747, 1958, 6337, 2455, 3316, 7547, 7095, 12184, 17, 16, 24714, 1935, 2687, 17, 1930, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 3]}, "items": [{"id": "p_3521", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_3522", "content": "N-methyl-D-aspartate [SEP]  for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy gr", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 1958, 6337, 2455, 3316, 7547, 7095, 12184, 17, 16, 24714, 1935, 2687, 17, 1930, 56, 17, 4963, 17, 46, 17, 12878, 12, 3]}, "items": [{"id": "p_3522", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_3523", "content": "NMDA [SEP] ty against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy group in", "tokenized_content": [2, 10976, 3, 6227, 3316, 7547, 7095, 12184, 17, 16, 24714, 1935, 2687, 17, 1930, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 17, 2719, 10060, 1922, 2518, 18, 3]}, "items": [{"id": "p_3523", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_3524", "content": "seizures [SEP] ocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy group in the alpha-positio", "tokenized_content": [2, 10060, 3, 5084, 23457, 2053, 17, 16, 24714, 1935, 2687, 17, 1930, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 17, 2719, 10060, 1922, 2518, 18, 13039, 1956, 3]}, "items": [{"id": "p_3524", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3525", "content": "Steroids [SEP] acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy group in the alpha-position and 5-H in the a", "tokenized_content": [2, 13039, 3, 2687, 17, 1930, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 17, 2719, 10060, 1922, 2518, 18, 13039, 1956, 1920, 23, 17, 8275, 2210, 1922, 1920, 3]}, "items": [{"id": "p_3525", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3526", "content": "status epilepticus [SEP] pilocarpine (416 mg/kg, s.c.)-induced limbic motor seizures and status epilepticus (ED50 values, 7.0-18.7 mg/kg, i.p.). The corresponding epimers ", "tokenized_content": [2, 3642, 16304, 1957, 3, 7547, 7095, 12184, 12, 28286, 2786, 19, 3621, 16, 61, 18, 45, 18, 13, 17, 2719, 20590, 4842, 10060, 1930, 3642, 16304, 1957, 12, 3347, 3382, 3]}, "items": [{"id": "p_3526", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_3527", "content": "steroids [SEP] potent (ED50 values, 33.8-63.5, i.p.). Although the neuroactive steroids were considerably less potent than the benzodiazepine clonazepa", "tokenized_content": [2, 13039, 3, 6828, 12, 3347, 3382, 2851, 16, 3401, 18, 28, 17, 4968, 18, 25, 16, 51, 18, 58, 18, 13, 18, 2876, 1920, 3366, 3849, 13039, 1985, 9760, 2941, 3]}, "items": [{"id": "p_3527", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3528", "content": "benzodiazepine [SEP] the neuroactive steroids were considerably less potent than the benzodiazepine clonazepam in protecting against pilocarpine seizures, steroids", "tokenized_content": [2, 27266, 3, 1920, 3366, 3849, 13039, 1985, 9760, 2941, 6828, 2254, 1920, 27266, 6138, 28231, 1922, 15145, 3316, 7547, 7095, 12184, 10060, 16, 13039, 3]}, "items": [{"id": "p_3528", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_3529", "content": "clonazepam [SEP]  steroids were considerably less potent than the benzodiazepine clonazepam in protecting against pilocarpine seizures, steroids with the 5", "tokenized_content": [2, 6138, 28231, 3, 13039, 1985, 9760, 2941, 6828, 2254, 1920, 27266, 6138, 28231, 1922, 15145, 3316, 7547, 7095, 12184, 10060, 16, 13039, 1956, 1920, 25, 3]}, "items": [{"id": "p_3529", "content": "Clonazepam [SEP] An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absenc", "score": 1, "type": null, "tokenized_content": [2, 6138, 28231, 3, 1925, 26572, 2031, 2251, 1958, 2980, 3584, 1927, 10060, 16, 2710, 15924, 24970, 2014, 2019, 3490, 10060, 16, 27462, 1961, 9741, 16, 1930, 2872, 2135, 3]}]}
{"query": {"id": "q_3530", "content": "seizure [SEP] ocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy group in the alpha-positi", "tokenized_content": [2, 11015, 3, 5084, 23457, 2053, 17, 16, 24714, 1935, 2687, 17, 1930, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 17, 2719, 10060, 1922, 2518, 18, 13039, 1956, 3]}, "items": [{"id": "p_3530", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3531", "content": "toxicity [SEP] dicating that some neuroactive steroids may have lower relative toxicity. Steroids with the 5 alpha,3 alpha- or 5 beta,3 alpha-configura", "tokenized_content": [2, 5532, 3, 9192, 2287, 1988, 2673, 3366, 3849, 13039, 2278, 2162, 2826, 3338, 5532, 18, 13039, 1956, 1920, 25, 4595, 16, 23, 4595, 17, 2014, 25, 4666, 16, 23, 4595, 3]}, "items": [{"id": "p_3531", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3532", "content": "steroid [SEP] potent (ED50 values, 33.8-63.5, i.p.). Although the neuroactive steroids were considerably less potent than the benzodiazepine clonazep", "tokenized_content": [2, 9507, 3, 6828, 12, 3347, 3382, 2851, 16, 3401, 18, 28, 17, 4968, 18, 25, 16, 51, 18, 58, 18, 13, 18, 2876, 1920, 3366, 3849, 13039, 1985, 9760, 2941, 3]}, "items": [{"id": "p_3532", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3533", "content": "N-butyl-deoxynojirimycin [SEP] The safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and ", "tokenized_content": [2, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3665, 3, 1920, 5407, 1930, 4348, 1927, 3921, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3665, 12, 2160, 17, 3]}, "items": [{"id": "p_3533", "content": "miglustat [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22161, 5277, 21238, 3, 3]}]}
{"query": {"id": "q_3534", "content": "SC-48334 [SEP] he safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD", "tokenized_content": [2, 2160, 17, 29713, 4857, 3, 2234, 5407, 1930, 4348, 1927, 3921, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3665, 12, 2160, 17, 29713, 4857, 13, 1930, 28666, 22389, 3]}, "items": [{"id": "p_3534", "content": "miglustat [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22161, 5277, 21238, 3, 3]}]}
{"query": {"id": "q_3535", "content": "zidovudine [SEP] efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3.", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 4348, 1927, 3921, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3665, 12, 2160, 17, 29713, 4857, 13, 1930, 28666, 22389, 1020, 20597, 1922, 3]}, "items": [{"id": "p_3535", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3536", "content": "HIV-1 infection [SEP] tyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3.", "tokenized_content": [2, 3525, 17, 21, 2909, 3, 28483, 17, 24986, 1037, 11801, 3027, 14930, 3665, 12, 2160, 17, 29713, 4857, 13, 1930, 28666, 22389, 1020, 20597, 1922, 2132, 1956, 3525, 17, 21, 3]}, "items": [{"id": "p_3536", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_3537", "content": "N-butyl-deoxynojirimycin [SEP] to evaluate the safety and activity of combination therapy with N-butyl-deoxynojirimycin (SC-48334) (an alpha-glucosidase I inhibitor) and zidovudine ve", "tokenized_content": [2, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3665, 3, 1942, 4323, 1920, 5407, 1930, 2455, 1927, 3921, 3181, 1956, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3]}, "items": [{"id": "p_3537", "content": "miglustat [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22161, 5277, 21238, 3, 3]}]}
{"query": {"id": "q_3538", "content": "SC-48334 [SEP]  activity of combination therapy with N-butyl-deoxynojirimycin (SC-48334) (an alpha-glucosidase I inhibitor) and zidovudine versus zidov", "tokenized_content": [2, 2160, 17, 29713, 4857, 3, 2455, 1927, 3921, 3181, 1956, 56, 17, 16936, 17, 24986, 1037, 11801, 3027, 14930, 3665, 12, 2160, 17, 29713, 4857, 13, 12, 1925, 4595, 17, 3]}, "items": [{"id": "p_3538", "content": "miglustat [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22161, 5277, 21238, 3, 3]}]}
{"query": {"id": "q_3539", "content": "zidovudine [SEP] xynojirimycin (SC-48334) (an alpha-glucosidase I inhibitor) and zidovudine versus zidovudine alone. Patients with 200 to 500 CD4 cells/mm3", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 20593, 11873, 11801, 3027, 14930, 3665, 12, 2160, 17, 29713, 4857, 13, 12, 1925, 4595, 17, 24755, 51, 4106, 13, 1930, 28666, 22389, 1020, 20597, 3]}, "items": [{"id": "p_3539", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3540", "content": "immunodeficiency [SEP] s/ml) was below the in vitro inhibitory concentration for human immunodeficiency virus (HIV). The mean increase in CD4 cells at week 4 was 73.8 ", "tokenized_content": [2, 13141, 3, 61, 19, 2646, 13, 1982, 4535, 1920, 1922, 3596, 5431, 3110, 1958, 2616, 13141, 3413, 12, 3525, 13, 18, 1920, 2667, 2760, 1922, 4095, 2094, 2019, 2982, 24, 3]}, "items": [{"id": "p_3540", "content": "Immunologic Deficiency Syndromes [SEP] Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21049, 6179, 12688, 3, 12688, 1922, 2154, 2276, 1977, 43, 6179, 2014, 7374, 1922, 1920, 3531, 1927, 7611, 16, 3108, 3689, 2014, 16601, 18, 3]}]}
{"query": {"id": "q_3541", "content": "Diarrhea [SEP] d five (45%) and two (14%) at week 24 (p = 0.08), respectively. Diarrhea, flatulence, abdominal pain, and weight loss were common for co", "tokenized_content": [2, 11904, 3, 46, 3628, 12, 3607, 9, 13, 1930, 2288, 12, 2607, 9, 13, 2019, 2982, 2686, 12, 58, 33, 20, 18, 6709, 13, 16, 2763, 18, 11904, 16, 9778, 3]}, "items": [{"id": "p_3541", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_3542", "content": "flatulence [SEP] %) and two (14%) at week 24 (p = 0.08), respectively. Diarrhea, flatulence, abdominal pain, and weight loss were common for combination re", "tokenized_content": [2, 9778, 25916, 3, 9, 13, 1930, 2288, 12, 2607, 9, 13, 2019, 2982, 2686, 12, 58, 33, 20, 18, 6709, 13, 16, 2763, 18, 11904, 16, 9778, 25916, 16, 6900, 3]}, "items": [{"id": "p_3542", "content": "Flatulence [SEP] Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9778, 25916, 3, 3372, 2014, 2990, 1927, 4422, 1922, 1920, 8375, 6482, 2154, 2278, 1998, 2887, 7667, 2596, 1920, 1925, 1957, 18, 3]}]}
{"query": {"id": "q_3543", "content": "abdominal pain [SEP] 14%) at week 24 (p = 0.08), respectively. Diarrhea, flatulence, abdominal pain, and weight loss were common for combination recipients.(ABSTRA", "tokenized_content": [2, 6900, 3594, 3, 2607, 9, 13, 2019, 2982, 2686, 12, 58, 33, 20, 18, 6709, 13, 16, 2763, 18, 11904, 16, 9778, 25916, 16, 6900, 3594, 16, 1930, 3388, 3257, 3]}, "items": [{"id": "p_3543", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_3544", "content": "weight loss [SEP]  0.08), respectively. Diarrhea, flatulence, abdominal pain, and weight loss were common for combination recipients.(ABSTRACT TRUNCATED AT 2", "tokenized_content": [2, 3388, 3257, 3, 20, 18, 6709, 13, 16, 2763, 18, 11904, 16, 9778, 25916, 16, 6900, 3594, 16, 1930, 3388, 3257, 1985, 3059, 1958, 3921, 9336, 18, 12, 10929, 9530, 3]}, "items": [{"id": "p_3544", "content": "Weight Loss [SEP] Decrease in existing BODY WEIGHT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 3257, 3, 3714, 1922, 6124, 3362, 3388, 18, 3]}]}
{"query": {"id": "q_3545", "content": "N10-propargyl-5,8-dideazafolic acid [SEP] al and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB 3717).", "tokenized_content": [2, 13007, 1008, 17, 5062, 2419, 2199, 17, 25, 16, 28, 17, 2811, 5376, 12813, 25203, 1030, 2687, 3, 1969, 1930, 2535, 2351, 1956, 1920, 7330, 19743, 2010, 8921, 4106, 13007, 3]}, "items": [{"id": "p_3545", "content": "CB 3717 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5529, 27711, 1027, 3, 3]}]}
{"query": {"id": "q_3546", "content": "CB 3717 [SEP] idylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB 3717).", "tokenized_content": [2, 5529, 27711, 1027, 3, 2313, 9075, 8921, 4106, 13007, 1008, 17, 5062, 2419, 2199, 17, 25, 16, 28, 17, 2811, 5376, 12813, 25203, 1030, 2687, 12, 5529, 27711, 1027, 13, 3]}, "items": [{"id": "p_3546", "content": "CB 3717 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5529, 27711, 1027, 3, 3]}]}
{"query": {"id": "q_3547", "content": "CB 3717 [SEP] CB 3717, N10-propargyl-5,8-dideazafolic acid, is a tight-binding inhibi", "tokenized_content": [2, 5529, 27711, 1027, 3, 5529, 27711, 1027, 16, 13007, 1008, 17, 5062, 2419, 2199, 17, 25, 16, 28, 17, 2811, 5376, 12813, 25203, 1030, 2687, 16, 1977, 43, 8246, 17, 3]}, "items": [{"id": "p_3547", "content": "CB 3717 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5529, 27711, 1027, 3, 3]}]}
{"query": {"id": "q_3548", "content": "N10-propargyl-5,8-dideazafolic acid [SEP] CB 3717, N10-propargyl-5,8-dideazafolic acid, is a tight-binding inhibitor of thymidylate synthase (TS) whos", "tokenized_content": [2, 13007, 1008, 17, 5062, 2419, 2199, 17, 25, 16, 28, 17, 2811, 5376, 12813, 25203, 1030, 2687, 3, 5529, 27711, 1027, 16, 13007, 1008, 17, 5062, 2419, 2199, 17, 25, 3]}, "items": [{"id": "p_3548", "content": "CB 3717 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5529, 27711, 1027, 3, 3]}]}
{"query": {"id": "q_3549", "content": "cytotoxicity [SEP] is a tight-binding inhibitor of thymidylate synthase (TS) whose cytotoxicity is mediated solely through the inhibition of this enzyme. Recen", "tokenized_content": [2, 8470, 3, 1977, 43, 8246, 17, 2743, 4106, 1927, 7330, 19743, 2010, 8921, 12, 4894, 13, 6098, 8470, 1977, 3434, 10870, 2596, 1920, 3523, 1927, 2052, 4113, 18, 3169, 1022, 3]}, "items": [{"id": "p_3549", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3550", "content": "breast cancer [SEP]  early clinical studies with CB 3717, activity has been seen in breast cancer, ovarian cancer, hepatoma, and mesothelioma. Toxicities include", "tokenized_content": [2, 3739, 2539, 3, 3120, 2535, 2351, 1956, 5529, 27711, 1027, 16, 2455, 2258, 2252, 3945, 1922, 3739, 2539, 16, 6751, 2539, 16, 23980, 16, 1930, 25986, 18, 15251, 3951, 3]}, "items": [{"id": "p_3550", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3551", "content": "ovarian cancer [SEP]  studies with CB 3717, activity has been seen in breast cancer, ovarian cancer, hepatoma, and mesothelioma. Toxicities included hepatotoxicity", "tokenized_content": [2, 6751, 2539, 3, 2351, 1956, 5529, 27711, 1027, 16, 2455, 2258, 2252, 3945, 1922, 3739, 2539, 16, 6751, 2539, 16, 23980, 16, 1930, 25986, 18, 15251, 3063, 24126, 3]}, "items": [{"id": "p_3551", "content": "Ovarian Neoplasms [SEP] Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin", "score": 1, "type": null, "tokenized_content": [2, 6751, 15347, 3, 3861, 2014, 2539, 1927, 1920, 13464, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2611, 2032, 5947, 3147, 1942, 1920, 2960, 1927, 4853, 3]}]}
{"query": {"id": "q_3552", "content": "hepatoma [SEP]  3717, activity has been seen in breast cancer, ovarian cancer, hepatoma, and mesothelioma. Toxicities included hepatotoxicity, malaise,", "tokenized_content": [2, 23980, 3, 27711, 1027, 16, 2455, 2258, 2252, 3945, 1922, 3739, 2539, 16, 6751, 2539, 16, 23980, 16, 1930, 25986, 18, 15251, 3063, 24126, 16, 3054, 5504, 4127, 16, 3]}, "items": [{"id": "p_3552", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_3553", "content": "mesothelioma [SEP] y has been seen in breast cancer, ovarian cancer, hepatoma, and mesothelioma. Toxicities included hepatotoxicity, malaise, and dose-limiting", "tokenized_content": [2, 25986, 3, 67, 2258, 2252, 3945, 1922, 3739, 2539, 16, 6751, 2539, 16, 23980, 16, 1930, 25986, 18, 15251, 3063, 24126, 16, 3054, 5504, 4127, 16, 1930, 3253, 17, 8051, 3]}, "items": [{"id": "p_3553", "content": "Mesothelioma [SEP] A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some region", "score": 1, "type": null, "tokenized_content": [2, 25986, 3, 43, 2798, 3595, 2037, 18024, 3583, 2960, 12, 28257, 16, 6483, 9280, 16, 10796, 26872, 13, 18, 2176, 5107, 1966, 4949, 14685, 1927, 2094, 16, 1956, 2673, 3031, 3]}]}
{"query": {"id": "q_3554", "content": "Toxicities [SEP] n in breast cancer, ovarian cancer, hepatoma, and mesothelioma. Toxicities included hepatotoxicity, malaise, and dose-limiting nephrotoxic", "tokenized_content": [2, 15251, 3, 56, 1922, 3739, 2539, 16, 6751, 2539, 16, 23980, 16, 1930, 25986, 18, 15251, 3063, 24126, 16, 3054, 5504, 4127, 16, 1930, 3253, 17, 8051, 22994, 10605, 3]}, "items": [{"id": "p_3554", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3555", "content": "hepatotoxicity [SEP] ovarian cancer, hepatoma, and mesothelioma. Toxicities included hepatotoxicity, malaise, and dose-limiting nephrotoxicity. This latter effect ", "tokenized_content": [2, 24126, 3, 6751, 2539, 16, 23980, 16, 1930, 25986, 18, 15251, 3063, 24126, 16, 3054, 5504, 4127, 16, 1930, 3253, 17, 8051, 27880, 18, 2052, 6296, 2495, 3]}, "items": [{"id": "p_3555", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3556", "content": "malaise [SEP] hepatoma, and mesothelioma. Toxicities included hepatotoxicity, malaise, and dose-limiting nephrotoxicity. This latter effect is though", "tokenized_content": [2, 3054, 5504, 4127, 3, 23980, 16, 1930, 25986, 18, 15251, 3063, 24126, 16, 3054, 5504, 4127, 16, 1930, 3253, 17, 8051, 27880, 18, 2052, 6296, 2495, 1977, 4170, 3]}, "items": [{"id": "p_3556", "content": "Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re", "score": 1, "type": null, "tokenized_content": [2, 8656, 3, 1920, 3360, 1927, 12615, 8254, 2894, 43, 3047, 1927, 28187, 16, 5018, 2014, 3841, 16, 4378, 2007, 43, 3261, 4796, 1958, 2778, 1930, 1964, 3]}]}
{"query": {"id": "q_3557", "content": "nephrotoxicity [SEP]  Toxicities included hepatotoxicity, malaise, and dose-limiting nephrotoxicity. This latter effect is thought to be due to drug precipitation ", "tokenized_content": [2, 27880, 3, 15251, 3063, 24126, 16, 3054, 5504, 4127, 16, 1930, 3253, 17, 8051, 27880, 18, 2052, 6296, 2495, 1977, 6212, 1942, 1998, 2810, 1942, 2838, 10649, 3]}, "items": [{"id": "p_3557", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3558", "content": "renal toxicity [SEP] n nephrotoxicity may have been achieved with only 1 instance of renal toxicity in 10 patients. Hepatotoxicity and malaise are again the most f", "tokenized_content": [2, 4604, 5532, 3, 56, 27880, 2278, 2162, 2252, 5032, 1956, 2444, 21, 7303, 1927, 4604, 5532, 1922, 2119, 2132, 18, 24126, 1930, 3054, 5504, 4127, 2032, 3116, 1920, 2501, 48, 3]}, "items": [{"id": "p_3558", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3559", "content": "Hepatotoxicity [SEP] achieved with only 1 instance of renal toxicity in 10 patients. Hepatotoxicity and malaise are again the most frequent side effects. Evidence ", "tokenized_content": [2, 24126, 3, 5032, 1956, 2444, 21, 7303, 1927, 4604, 5532, 1922, 2119, 2132, 18, 24126, 1930, 3054, 5504, 4127, 2032, 3116, 1920, 2501, 6439, 4159, 2564, 18, 3095, 3]}, "items": [{"id": "p_3559", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3560", "content": "Ethopropazine [SEP] Ethopropazine and benztropine in neuroleptic-induced parkinsonism.", "tokenized_content": [2, 3293, 27379, 10119, 3, 3293, 27379, 10119, 1930, 7334, 1997, 2011, 2053, 1922, 20325, 17920, 17, 2719, 26214, 18, 3]}, "items": [{"id": "p_3560", "content": "profenamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3150, 11496, 25157, 3, 3]}]}
{"query": {"id": "q_3561", "content": "benztropine [SEP] Ethopropazine and benztropine in neuroleptic-induced parkinsonism.", "tokenized_content": [2, 7334, 1997, 2011, 2053, 3, 3293, 27379, 10119, 1930, 7334, 1997, 2011, 2053, 1922, 20325, 17920, 17, 2719, 26214, 18, 3]}, "items": [{"id": "p_3561", "content": "Benztropine [SEP] A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also ", "score": 1, "type": null, "tokenized_content": [2, 7334, 1997, 2011, 2053, 3, 43, 20424, 3500, 20318, 8151, 1988, 2258, 2252, 2251, 1922, 1920, 9371, 2311, 1927, 10124, 2573, 18, 7334, 1997, 2011, 2053, 2222, 3]}]}
{"query": {"id": "q_3562", "content": "parkinsonism [SEP] Ethopropazine and benztropine in neuroleptic-induced parkinsonism.", "tokenized_content": [2, 26214, 3, 3293, 27379, 10119, 1930, 7334, 1997, 2011, 2053, 1922, 20325, 17920, 17, 2719, 26214, 18, 3]}, "items": [{"id": "p_3562", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_3563", "content": "ethopropazine [SEP] In a 12-week controlled study ethopropazine was compared to benztropine in the treatment of parkinsonism in", "tokenized_content": [2, 3293, 27379, 10119, 3, 1922, 43, 2369, 17, 2982, 4642, 2161, 3293, 27379, 10119, 1982, 2452, 1942, 7334, 1997, 2011, 2053, 1922, 1920, 2311, 1927, 26214, 1922, 3]}, "items": [{"id": "p_3563", "content": "profenamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3150, 11496, 25157, 3, 3]}]}
{"query": {"id": "q_3564", "content": "benztropine [SEP] In a 12-week controlled study ethopropazine was compared to benztropine in the treatment of parkinsonism induced by fluphenazine enanth", "tokenized_content": [2, 7334, 1997, 2011, 2053, 3, 1922, 43, 2369, 17, 2982, 4642, 2161, 3293, 27379, 10119, 1982, 2452, 1942, 7334, 1997, 2011, 2053, 1922, 1920, 2311, 1927, 26214, 2719, 2007, 2848, 3]}, "items": [{"id": "p_3564", "content": "Benztropine [SEP] A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also ", "score": 1, "type": null, "tokenized_content": [2, 7334, 1997, 2011, 2053, 3, 43, 20424, 3500, 20318, 8151, 1988, 2258, 2252, 2251, 1922, 1920, 9371, 2311, 1927, 10124, 2573, 18, 7334, 1997, 2011, 2053, 2222, 3]}]}
{"query": {"id": "q_3565", "content": "parkinsonism [SEP] y ethopropazine was compared to benztropine in the treatment of parkinsonism induced by fluphenazine enanthate in 60 schizophrenic outpatien", "tokenized_content": [2, 26214, 3, 67, 3293, 27379, 10119, 1982, 2452, 1942, 7334, 1997, 2011, 2053, 1922, 1920, 2311, 1927, 26214, 2719, 2007, 2848, 17616, 10119, 2066, 7744, 2010, 1922, 3276, 28247, 2397, 3]}, "items": [{"id": "p_3565", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_3566", "content": "fluphenazine enanthate [SEP] ared to benztropine in the treatment of parkinsonism induced by fluphenazine enanthate in 60 schizophrenic outpatients. Ethopropazine and benztropine ", "tokenized_content": [2, 2848, 17616, 10119, 2066, 7744, 2010, 3, 2032, 1007, 1942, 7334, 1997, 2011, 2053, 1922, 1920, 2311, 1927, 26214, 2719, 2007, 2848, 17616, 10119, 2066, 7744, 2010, 1922, 3276, 28247, 3]}, "items": [{"id": "p_3566", "content": "fluphenazine enanthate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2848, 17616, 10119, 2066, 7744, 2010, 3, 3]}]}
{"query": {"id": "q_3567", "content": "schizophrenic [SEP] eatment of parkinsonism induced by fluphenazine enanthate in 60 schizophrenic outpatients. Ethopropazine and benztropine were found to be equ", "tokenized_content": [2, 28247, 3, 13619, 2017, 1927, 26214, 2719, 2007, 2848, 17616, 10119, 2066, 7744, 2010, 1922, 3276, 28247, 20204, 18, 3293, 27379, 10119, 1930, 7334, 1997, 2011, 2053, 1985, 2435, 1942, 3]}, "items": [{"id": "p_3567", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_3568", "content": "Ethopropazine [SEP] uced by fluphenazine enanthate in 60 schizophrenic outpatients. Ethopropazine and benztropine were found to be equally effective in controlli", "tokenized_content": [2, 3293, 27379, 10119, 3, 8577, 1919, 2007, 2848, 17616, 10119, 2066, 7744, 2010, 1922, 3276, 28247, 20204, 18, 3293, 27379, 10119, 1930, 7334, 1997, 2011, 2053, 1985, 2435, 1942, 1998, 3]}, "items": [{"id": "p_3568", "content": "profenamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3150, 11496, 25157, 3, 3]}]}
{"query": {"id": "q_3569", "content": "parkinsonian symptoms [SEP] d benztropine were found to be equally effective in controlling parkinsonian symptoms and were as efficacious as procyclidine, their previous antipar", "tokenized_content": [2, 10124, 3122, 3601, 3, 46, 7334, 1997, 2011, 2053, 1985, 2435, 1942, 1998, 9208, 3655, 1922, 7138, 10124, 3122, 3601, 1930, 1985, 1966, 15860, 1966, 9823, 3143, 5802, 16, 2310, 3]}, "items": [{"id": "p_3569", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_3570", "content": "procyclidine [SEP] in controlling parkinsonian symptoms and were as efficacious as procyclidine, their previous antiparkinsonian drug. However, benztropine tre", "tokenized_content": [2, 9823, 3143, 5802, 3, 1922, 7138, 10124, 3122, 3601, 1930, 1985, 1966, 15860, 1966, 9823, 3143, 5802, 16, 2310, 2555, 24290, 14488, 6114, 1022, 2838, 18, 2406, 16, 7334, 1997, 3]}, "items": [{"id": "p_3570", "content": "Procyclidine [SEP] A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorde", "score": 1, "type": null, "tokenized_content": [2, 9823, 3143, 5802, 3, 43, 20318, 8151, 1988, 17553, 1920, 2877, 17, 3068, 7104, 1930, 1977, 2251, 1922, 1920, 2311, 1927, 2838, 17, 2719, 21346, 3553, 25238, 1923, 2054, 2538, 1021, 3]}]}
{"query": {"id": "q_3571", "content": "tardive dyskinesia [SEP] ver, benztropine treated patients had a significant increase in tardive dyskinesia compared to their condition during procyclindine treatment, and", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 3566, 16, 7334, 1997, 2011, 2053, 2868, 2132, 2430, 43, 2228, 2760, 1922, 14517, 7408, 1961, 3890, 26682, 2452, 1942, 2310, 2625, 2409, 9823, 3]}, "items": [{"id": "p_3571", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3572", "content": "procyclindine [SEP] crease in tardive dyskinesia compared to their condition during procyclindine treatment, and significantly more anxiety and depression than e", "tokenized_content": [2, 9823, 3143, 2762, 2053, 3, 3478, 2051, 1922, 14517, 7408, 1961, 3890, 26682, 2452, 1942, 2310, 2625, 2409, 9823, 3143, 2762, 2053, 2311, 16, 1930, 2567, 2253, 5592, 1930, 4621, 3]}, "items": [{"id": "p_3572", "content": "Procyclidine [SEP] A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorde", "score": 1, "type": null, "tokenized_content": [2, 9823, 3143, 5802, 3, 43, 20318, 8151, 1988, 17553, 1920, 2877, 17, 3068, 7104, 1930, 1977, 2251, 1922, 1920, 2311, 1927, 2838, 17, 2719, 21346, 3553, 25238, 1923, 2054, 2538, 1021, 3]}]}
{"query": {"id": "q_3573", "content": "anxiety [SEP] ondition during procyclindine treatment, and significantly more anxiety and depression than ethopropazine treated patients. This sugges", "tokenized_content": [2, 5592, 3, 1990, 2243, 2409, 9823, 3143, 2762, 2053, 2311, 16, 1930, 2567, 2253, 5592, 1930, 4621, 2254, 3293, 27379, 10119, 2868, 2132, 18, 2052, 2683, 3]}, "items": [{"id": "p_3573", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_3574", "content": "depression [SEP] ing procyclindine treatment, and significantly more anxiety and depression than ethopropazine treated patients. This suggests that benztro", "tokenized_content": [2, 4621, 3, 30393, 9823, 3143, 2762, 2053, 2311, 16, 1930, 2567, 2253, 5592, 1930, 4621, 2254, 3293, 27379, 10119, 2868, 2132, 18, 2052, 4015, 1988, 7334, 1997, 1037, 3]}, "items": [{"id": "p_3574", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_3575", "content": "alpha-tocopherol [SEP] Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.", "tokenized_content": [2, 4595, 17, 21432, 3, 2495, 1927, 4595, 17, 21432, 1930, 20519, 2325, 3812, 1990, 20375, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3575", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_3576", "content": "deferoxamine [SEP] Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.", "tokenized_content": [2, 20519, 2325, 3812, 3, 2495, 1927, 4595, 17, 21432, 1930, 20519, 2325, 3812, 1990, 20375, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3576", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_3577", "content": "methamphetamine [SEP] Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.", "tokenized_content": [2, 20375, 3, 2495, 1927, 4595, 17, 21432, 1930, 20519, 2325, 3812, 1990, 20375, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3577", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3578", "content": "neurotoxicity [SEP] of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.", "tokenized_content": [2, 18034, 3, 1927, 4595, 17, 21432, 1930, 20519, 2325, 3812, 1990, 20375, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3578", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3579", "content": "Methamphetamine [SEP] Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to be assoc", "tokenized_content": [2, 20375, 3, 20375, 12, 2488, 13, 17, 2719, 12214, 18034, 1977, 9283, 1942, 1998, 2088, 1994, 3]}, "items": [{"id": "p_3579", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3580", "content": "MA [SEP] Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to be associate", "tokenized_content": [2, 2488, 3, 20375, 12, 2488, 13, 17, 2719, 12214, 18034, 1977, 9283, 1942, 1998, 11774, 3]}, "items": [{"id": "p_3580", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3581", "content": "neurotoxicity [SEP] Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to be associated with the increased formation of fr", "tokenized_content": [2, 18034, 3, 20375, 12, 2488, 13, 17, 2719, 12214, 18034, 1977, 9283, 1942, 1998, 2458, 1956, 1920, 2502, 3337, 1927, 2415, 3]}, "items": [{"id": "p_3581", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3582", "content": "alpha-tocopherol [SEP] d formation of free radicals. This study examined the effect of alpha-tocopherol (alpha-TC), a scavenger of reactive oxygen species, and deferox", "tokenized_content": [2, 4595, 17, 21432, 3, 46, 3337, 1927, 3294, 12467, 18, 2052, 2161, 3572, 1920, 2495, 1927, 4595, 17, 21432, 12, 4595, 17, 5283, 13, 16, 43, 21433, 1927, 6079, 4612, 3]}, "items": [{"id": "p_3582", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_3583", "content": "alpha-TC [SEP] e radicals. This study examined the effect of alpha-tocopherol (alpha-TC), a scavenger of reactive oxygen species, and deferoxamine (DFO", "tokenized_content": [2, 4595, 17, 5283, 3, 47, 12467, 18, 2052, 2161, 3572, 1920, 2495, 1927, 4595, 17, 21432, 12, 4595, 17, 5283, 13, 16, 43, 21433, 1927, 6079, 4612, 3038, 16, 1930, 3]}, "items": [{"id": "p_3583", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_3584", "content": "oxygen [SEP]  effect of alpha-tocopherol (alpha-TC), a scavenger of reactive oxygen species, and deferoxamine (DFO), an iron chelator, on the MA-in", "tokenized_content": [2, 4612, 3, 2495, 1927, 4595, 17, 21432, 12, 4595, 17, 5283, 13, 16, 43, 21433, 1927, 6079, 4612, 3038, 16, 1930, 20519, 2325, 3812, 12, 8122, 1037, 13, 16, 1925, 3]}, "items": [{"id": "p_3584", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_3585", "content": "deferoxamine [SEP] opherol (alpha-TC), a scavenger of reactive oxygen species, and deferoxamine (DFO), an iron chelator, on the MA-induced neurotoxicity. Male ", "tokenized_content": [2, 20519, 2325, 3812, 3, 11409, 6506, 1024, 12, 4595, 17, 5283, 13, 16, 43, 21433, 1927, 6079, 4612, 3038, 16, 1930, 20519, 2325, 3812, 12, 8122, 1037, 13, 16, 1925, 3]}, "items": [{"id": "p_3585", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_3586", "content": "DFO [SEP] -TC), a scavenger of reactive oxygen species, and deferoxamine (DFO), an iron chelator, on the MA-induced neurotoxicity. Male rats ", "tokenized_content": [2, 8122, 1037, 3, 17, 5283, 13, 16, 43, 21433, 1927, 6079, 4612, 3038, 16, 1930, 20519, 2325, 3812, 12, 8122, 1037, 13, 16, 1925, 5680, 28914, 16, 1990, 1920, 2488, 3]}, "items": [{"id": "p_3586", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_3587", "content": "iron [SEP] cavenger of reactive oxygen species, and deferoxamine (DFO), an iron chelator, on the MA-induced neurotoxicity. Male rats were treat", "tokenized_content": [2, 5680, 3, 12207, 2029, 1915, 1927, 6079, 4612, 3038, 16, 1930, 20519, 2325, 3812, 12, 8122, 1037, 13, 16, 1925, 5680, 28914, 16, 1990, 1920, 2488, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_3587", "content": "Iron [SEP] A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBI", "score": 1, "type": null, "tokenized_content": [2, 5680, 3, 43, 16790, 6149, 1956, 11241, 17530, 2650, 16, 11241, 2529, 3179, 16, 1930, 11241, 3388, 4288, 18, 5140, 18, 2176, 1977, 1925, 4415, 18690, 1927, 3243, 6292, 1033, 3]}]}
{"query": {"id": "q_3588", "content": "dopamine [SEP] Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to be associated with the increas", "tokenized_content": [2, 7964, 3, 20375, 12, 2488, 13, 17, 2719, 12214, 18034, 1977, 9283, 1942, 1998, 2458, 1956, 1920, 2203, 1934, 3]}, "items": [{"id": "p_3588", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3589", "content": "DA [SEP] 0 min before MA administration. The concentrations of dopamine (DA), serotonin and their metabolites decreased significantly after", "tokenized_content": [2, 3692, 3, 20, 2360, 3119, 2488, 4183, 18, 1920, 3295, 1927, 7964, 12, 3692, 13, 16, 11153, 1930, 2310, 6926, 3261, 2567, 2256, 3]}, "items": [{"id": "p_3589", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3590", "content": "serotonin [SEP]  before MA administration. The concentrations of dopamine (DA), serotonin and their metabolites decreased significantly after MA administ", "tokenized_content": [2, 11153, 3, 3119, 2488, 4183, 18, 1920, 3295, 1927, 7964, 12, 3692, 13, 16, 11153, 1930, 2310, 6926, 3261, 2567, 2256, 2488, 3318, 2184, 3]}, "items": [{"id": "p_3590", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3591", "content": "hyperthermia [SEP] nd DFO pretreatment. alpha-TC and DFO attenuated the MA-induced hyperthermia as well as the alterations in the locomotor activity. The level", "tokenized_content": [2, 21945, 3, 8026, 8122, 1037, 9111, 18, 4595, 17, 5283, 1930, 8122, 1037, 8060, 1920, 2488, 17, 2719, 21945, 1966, 2486, 1966, 1920, 5996, 1922, 1920, 13594, 2455, 18, 1920, 3]}, "items": [{"id": "p_3591", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_3592", "content": "glutathione [SEP] ity. The level of lipid peroxidation was higher and the reduced glutathione concentration was lower in the MA-treated rats. These changes w", "tokenized_content": [2, 9153, 3, 2176, 1012, 18, 1920, 2237, 1927, 4486, 14214, 1982, 2580, 1930, 1920, 3028, 9153, 3110, 1982, 2826, 1922, 1920, 2488, 17, 2868, 3615, 18, 2144, 2840, 65, 3]}, "items": [{"id": "p_3592", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_3593", "content": "neuronal damage [SEP] . This suggests that alpha-TC and DFO ameliorate the MA-induced neuronal damage by decreasing the level of oxidative stress.", "tokenized_content": [2, 5121, 4293, 3, 18, 2052, 4015, 1988, 4595, 17, 5283, 1930, 8122, 1037, 20611, 1920, 2488, 17, 2719, 5121, 4293, 2007, 7742, 1920, 2237, 1927, 5163, 3071, 18, 3]}, "items": [{"id": "p_3593", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_3594", "content": "dexamethasone [SEP] Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic", "tokenized_content": [2, 12681, 3, 2485, 1927, 12681, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 3]}, "items": [{"id": "p_3594", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3595", "content": "mesna [SEP] Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 4438, 2175, 3, 2485, 1927, 12681, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_3595", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_3596", "content": "ifosfamide [SEP] Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2485, 1927, 12681, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_3596", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3597", "content": "hemorrhagic [SEP] xamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 16052, 3, 23447, 23568, 11718, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_3597", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_3598", "content": "cystitis [SEP] with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 9446, 3678, 3, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_3598", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_3599", "content": "Hemorrhagic [SEP] AIM: Hemorrhagic cystitis (HC) is a limiting side-effect of chemotherapy with if", "tokenized_content": [2, 16052, 3, 3774, 30, 16052, 9446, 3678, 12, 4387, 13, 1977, 43, 8051, 4159, 17, 2495, 1927, 5318, 1956, 2647, 3]}, "items": [{"id": "p_3599", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_3600", "content": "cystitis [SEP] AIM: Hemorrhagic cystitis (HC) is a limiting side-effect of chemotherapy with ifosfamide ", "tokenized_content": [2, 9446, 3678, 3, 3774, 30, 16052, 9446, 3678, 12, 4387, 13, 1977, 43, 8051, 4159, 17, 2495, 1927, 5318, 1956, 2647, 1951, 6016, 16408, 1021, 3]}, "items": [{"id": "p_3600", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_3601", "content": "ifosfamide [SEP] ic cystitis (HC) is a limiting side-effect of chemotherapy with ifosfamide (IFS). In the study presented here, we investigated the use of ", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 3996, 9446, 3678, 12, 4387, 13, 1977, 43, 8051, 4159, 17, 2495, 1927, 5318, 1956, 2647, 1951, 6016, 16408, 1021, 12, 2647, 1036, 13, 3]}, "items": [{"id": "p_3601", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3602", "content": "IFS [SEP] (HC) is a limiting side-effect of chemotherapy with ifosfamide (IFS). In the study presented here, we investigated the use of dexam", "tokenized_content": [2, 2647, 1036, 3, 12, 4387, 13, 1977, 43, 8051, 4159, 17, 2495, 1927, 5318, 1956, 2647, 1951, 6016, 16408, 1021, 12, 2647, 1036, 13, 18, 1922, 1920, 2161, 3549, 3410, 3]}, "items": [{"id": "p_3602", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_3603", "content": "dexamethasone [SEP]  (IFS). In the study presented here, we investigated the use of dexamethasone in combination with mesna for the prevention of IFS-induced HC.", "tokenized_content": [2, 12681, 3, 12, 2647, 1036, 13, 18, 1922, 1920, 2161, 3549, 3410, 16, 2038, 3845, 1920, 2485, 1927, 12681, 1922, 3921, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1036, 3]}, "items": [{"id": "p_3603", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3604", "content": "mesna [SEP] e, we investigated the use of dexamethasone in combination with mesna for the prevention of IFS-induced HC. METHODS: Male Wistar rats", "tokenized_content": [2, 4438, 2175, 3, 47, 16, 2038, 3845, 1920, 2485, 1927, 12681, 1922, 3921, 1956, 4438, 2175, 1958, 1920, 5455, 1927, 2647, 1036, 17, 2719, 4387, 18, 2860, 30, 4005, 15668, 3]}, "items": [{"id": "p_3604", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_3605", "content": "Cystitis [SEP] aced with dexamethasone alone or with dexamethasone plus mesna. Cystitis was evaluated 24 h after its induction by the changes in bladde", "tokenized_content": [2, 9446, 3678, 3, 8298, 1007, 1956, 12681, 4298, 2014, 1956, 12681, 5390, 4438, 2175, 18, 9446, 3678, 1982, 3747, 2686, 50, 2256, 2496, 4408, 2007, 1920, 2840, 1922, 18208, 10882, 3]}, "items": [{"id": "p_3605", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_3606", "content": "Dexamethasone [SEP] oses of mesna alone when evaluated microscopically. CONCLUSION: Dexamethasone in combination with mesna was efficient in blocking IFS-induced", "tokenized_content": [2, 12681, 3, 3125, 1918, 1927, 4438, 2175, 4298, 2469, 3747, 26811, 18, 4180, 30, 12681, 1922, 3921, 1956, 4438, 2175, 1982, 5807, 1922, 7472, 2647, 1036, 17, 2719, 3]}, "items": [{"id": "p_3606", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3607", "content": "MK-801 [SEP] Behavioral effects of MK-801 on reserpine-treated mice.", "tokenized_content": [2, 10539, 17, 23858, 3, 5343, 2564, 1927, 10539, 17, 23858, 1990, 1995, 1915, 12184, 17, 2868, 2518, 18, 3]}, "items": [{"id": "p_3607", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_3608", "content": "reserpine [SEP] Behavioral effects of MK-801 on reserpine-treated mice.", "tokenized_content": [2, 1995, 1915, 12184, 3, 5343, 2564, 1927, 10539, 17, 23858, 1990, 1995, 1915, 12184, 17, 2868, 2518, 18, 3]}, "items": [{"id": "p_3608", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3609", "content": "dizocilpine [SEP] The effects of dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor", "tokenized_content": [2, 2137, 13642, 10401, 12184, 3, 1920, 2564, 1927, 2137, 13642, 10401, 12184, 12, 10539, 17, 23858, 13, 16, 43, 22849, 9626, 2572, 2320, 56, 17, 4963, 17, 46, 17, 12878, 3]}, "items": [{"id": "p_3609", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_3610", "content": "MK-801 [SEP] The effects of dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagon", "tokenized_content": [2, 10539, 17, 23858, 3, 1920, 2564, 1927, 2137, 13642, 10401, 12184, 12, 10539, 17, 23858, 13, 16, 43, 22849, 9626, 2572, 2320, 56, 17, 4963, 17, 46, 17, 12878, 12, 3]}, "items": [{"id": "p_3610", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_3611", "content": "N-methyl-D-aspartate [SEP] The effects of dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, were studied on dopamine-related be", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 1920, 2564, 1927, 2137, 13642, 10401, 12184, 12, 10539, 17, 23858, 13, 16, 43, 22849, 9626, 2572, 2320, 56, 17, 4963, 17, 3]}, "items": [{"id": "p_3611", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_3612", "content": "NMDA [SEP] of dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, were studied on dopamine-related behavior", "tokenized_content": [2, 10976, 3, 1927, 2137, 13642, 10401, 12184, 12, 10539, 17, 23858, 13, 16, 43, 22849, 9626, 2572, 2320, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 8151, 3]}, "items": [{"id": "p_3612", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_3613", "content": "dopamine [SEP] -methyl-D-aspartate (NMDA) receptor antagonist, were studied on dopamine-related behaviors induced by reserpine treatments. This study f", "tokenized_content": [2, 7964, 3, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 8151, 16, 1985, 3942, 1990, 7964, 17, 2712, 5888, 2719, 2007, 1995, 1915, 12184, 4930, 18, 2052, 2161, 3]}, "items": [{"id": "p_3613", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3614", "content": "reserpine [SEP] tagonist, were studied on dopamine-related behaviors induced by reserpine treatments. This study focuses on behavioral syndromes that may", "tokenized_content": [2, 1995, 1915, 12184, 3, 5218, 13339, 2156, 16, 1985, 3942, 1990, 7964, 17, 2712, 5888, 2719, 2007, 1995, 1915, 12184, 4930, 18, 2052, 2161, 13073, 1990, 5343, 12688, 1988, 2278, 3]}, "items": [{"id": "p_3614", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3615", "content": "Parkinson's disease [SEP] udy focuses on behavioral syndromes that may used as models for Parkinson's disease, or tardive dyskinesia, and its response after glutamatergic bl", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 19803, 1012, 13073, 1990, 5343, 12688, 1988, 2278, 2251, 1966, 3130, 1958, 10124, 11, 61, 2573, 16, 2014, 14517, 7408, 1961, 3890, 26682, 16, 1930, 3]}, "items": [{"id": "p_3615", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3616", "content": "tardive dyskinesia [SEP] l syndromes that may used as models for Parkinson's disease, or tardive dyskinesia, and its response after glutamatergic blockage. Reserpine (1 mg", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 54, 12688, 1988, 2278, 2251, 1966, 3130, 1958, 10124, 11, 61, 2573, 16, 2014, 14517, 7408, 1961, 3890, 26682, 16, 1930, 2496, 2644, 2256, 3]}, "items": [{"id": "p_3616", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3617", "content": "Reserpine [SEP] dive dyskinesia, and its response after glutamatergic blockage. Reserpine (1 mg/kg), administered once every other day for 4 days, produc", "tokenized_content": [2, 1995, 1915, 12184, 3, 6421, 1021, 3890, 26682, 16, 1930, 2496, 2644, 2256, 16922, 23615, 18, 1995, 1915, 12184, 12, 21, 2786, 19, 3621, 13, 16, 5254, 5361, 4808, 2303, 3]}, "items": [{"id": "p_3617", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3618", "content": "orofacial dyskinesia [SEP] nistered once every other day for 4 days, produced increases in orofacial dyskinesia, tongue protrusion and vacuous chewing in mice, which are signs", "tokenized_content": [2, 25027, 18703, 3890, 26682, 3, 17299, 3188, 5361, 4808, 2303, 3007, 1958, 24, 3000, 16, 4152, 4041, 1922, 25027, 18703, 3890, 26682, 16, 14761, 24384, 1930, 8062, 2080, 24394, 1922, 3]}, "items": [{"id": "p_3618", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_3619", "content": "tremor [SEP] signs indicative of tardive dyskinesia. Reserpine also produced tremor and catalepsy, which are signs suggestive of Parkinson's diseas", "tokenized_content": [2, 18388, 3, 6879, 10779, 1927, 14517, 7408, 1961, 3890, 26682, 18, 1995, 1915, 12184, 2222, 4152, 18388, 1930, 4233, 9431, 1012, 16, 2154, 2032, 6879, 12855, 1927, 10124, 11, 61, 3]}, "items": [{"id": "p_3619", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_3620", "content": "catalepsy [SEP] ative of tardive dyskinesia. Reserpine also produced tremor and catalepsy, which are signs suggestive of Parkinson's disease. MK-801 (0.1", "tokenized_content": [2, 4233, 9431, 1012, 3, 2019, 2320, 1927, 14517, 7408, 1961, 3890, 26682, 18, 1995, 1915, 12184, 2222, 4152, 18388, 1930, 4233, 9431, 1012, 16, 2154, 2032, 6879, 12855, 1927, 10124, 3]}, "items": [{"id": "p_3620", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_3621", "content": "apomophine [SEP]  (1 mg/kg), administered 90 min before the test and followed by apomophine injection (0.1 mg/kg) 5 min before the test, did not produce or", "tokenized_content": [2, 11466, 12492, 24888, 2912, 3, 12, 21, 2786, 19, 3621, 13, 16, 5254, 3865, 2360, 3119, 1920, 2648, 1930, 3489, 2007, 11466, 12492, 24888, 2912, 4107, 12, 20, 18, 21, 3]}, "items": [{"id": "p_3621", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_3622", "content": "oral dyskinesia [SEP] ne injection (0.1 mg/kg) 5 min before the test, did not produce oral dyskinesia in mice. On the other hand, reserpine induced increases in trem", "tokenized_content": [2, 4726, 3890, 26682, 3, 2069, 4107, 12, 20, 18, 21, 2786, 19, 3621, 13, 25, 2360, 3119, 1920, 2648, 16, 2811, 2084, 5074, 4726, 3890, 26682, 1922, 2518, 18, 1990, 3]}, "items": [{"id": "p_3622", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_3623", "content": "abnormal movements [SEP] rpine. These results show that reserpine produces different and abnormal movements, which are related to dose and schedule employed and can be con", "tokenized_content": [2, 4552, 8264, 3, 4822, 2053, 18, 2144, 2274, 2146, 1988, 1995, 1915, 12184, 9300, 2413, 1930, 4552, 8264, 16, 2154, 2032, 2712, 1942, 3253, 1930, 11660, 5789, 1930, 2112, 1998, 3]}, "items": [{"id": "p_3623", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3624", "content": "parkinsonian [SEP]  related to dose and schedule employed and can be considered as parkinsonian-like and tardive dsykinesia signs. The glutamatergic blockage p", "tokenized_content": [2, 10124, 3122, 3, 2712, 1942, 3253, 1930, 11660, 5789, 1930, 2112, 1998, 3311, 1966, 10124, 3122, 17, 3189, 1930, 14517, 7408, 1961, 4473, 23674, 2613, 2126, 6879, 18, 1920, 16922, 3]}, "items": [{"id": "p_3624", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3625", "content": "tardive dsykinesia [SEP] chedule employed and can be considered as parkinsonian-like and tardive dsykinesia signs. The glutamatergic blockage produced by NMDA can restore ", "tokenized_content": [2, 14517, 7408, 1961, 4473, 23674, 2613, 2126, 3, 10003, 10015, 1952, 5789, 1930, 2112, 1998, 3311, 1966, 10124, 3122, 17, 3189, 1930, 14517, 7408, 1961, 4473, 23674, 2613, 2126, 6879, 3]}, "items": [{"id": "p_3625", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3626", "content": "glyceryl trinitrate [SEP] Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine a", "tokenized_content": [2, 7757, 2199, 23501, 26813, 3, 2495, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 20557, 1927, 19365, 1033, 24431, 8782, 2007, 4876, 29043, 2053, 17, 11553, 43, 3]}, "items": [{"id": "p_3626", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_3627", "content": "sphincter of Oddi spasm [SEP] Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration.", "tokenized_content": [2, 20557, 1927, 19365, 1033, 24431, 3, 2495, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 20557, 1927, 19365, 1033, 24431, 8782, 2007, 4876, 29043, 2053, 17, 11553, 4183, 18, 3]}, "items": [{"id": "p_3627", "content": "Sphincter of Oddi Dysfunction [SEP] Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes ", "score": 1, "type": null, "tokenized_content": [2, 20557, 1927, 19365, 1033, 5273, 3, 6805, 2014, 3183, 9254, 4770, 5884, 1920, 20557, 1927, 19365, 1033, 1930, 2458, 1956, 13210, 5178, 1030, 18, 6598, 2840, 3]}]}
{"query": {"id": "q_3628", "content": "spasm [SEP] Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration.", "tokenized_content": [2, 24431, 3, 2495, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 20557, 1927, 19365, 1033, 24431, 8782, 2007, 4876, 29043, 2053, 17, 11553, 4183, 18, 3]}, "items": [{"id": "p_3628", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3629", "content": "prostigmine [SEP] of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration.", "tokenized_content": [2, 4876, 29043, 2053, 3, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 20557, 1927, 19365, 1033, 24431, 8782, 2007, 4876, 29043, 2053, 17, 11553, 4183, 18, 3]}, "items": [{"id": "p_3629", "content": "Neostigmine [SEP] A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gal", "score": 1, "type": null, "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 1920, 2311, 1927, 3057, 27618, 8572, 12413, 1937, 1930, 1942, 5267, 1920, 2564, 1927, 3760, 7327, 2356, 2427, 1966, 5179, 3]}]}
{"query": {"id": "q_3630", "content": "morphine [SEP] trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration.", "tokenized_content": [2, 11553, 3, 23501, 26813, 1990, 1920, 20557, 1927, 19365, 1033, 24431, 8782, 2007, 4876, 29043, 2053, 17, 11553, 4183, 18, 3]}, "items": [{"id": "p_3630", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3631", "content": "glyceryl trinitrate [SEP] OBJECTIVE: In this study the effect of glyceryl trinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was", "tokenized_content": [2, 7757, 2199, 23501, 26813, 3, 4470, 30, 1922, 2052, 2161, 1920, 2495, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 4876, 29043, 2053, 17, 11553, 17, 2719, 20557, 1927, 19365, 1033, 3]}, "items": [{"id": "p_3631", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_3632", "content": "prostigmine [SEP] JECTIVE: In this study the effect of glyceryl trinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was evaluated in nine ", "tokenized_content": [2, 4876, 29043, 2053, 3, 8988, 12323, 30, 1922, 2052, 2161, 1920, 2495, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 4876, 29043, 2053, 17, 11553, 17, 2719, 20557, 1927, 19365, 1033, 3]}, "items": [{"id": "p_3632", "content": "Neostigmine [SEP] A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gal", "score": 1, "type": null, "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 1920, 2311, 1927, 3057, 27618, 8572, 12413, 1937, 1930, 1942, 5267, 1920, 2564, 1927, 3760, 7327, 2356, 2427, 1966, 5179, 3]}]}
{"query": {"id": "q_3633", "content": "morphine [SEP] this study the effect of glyceryl trinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was evaluated in nine female pa", "tokenized_content": [2, 11553, 3, 2052, 2161, 1920, 2495, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 4876, 29043, 2053, 17, 11553, 17, 2719, 20557, 1927, 19365, 1033, 24431, 1982, 3747, 1922, 6360, 4232, 3]}, "items": [{"id": "p_3633", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3634", "content": "sphincter of Oddi spasm [SEP] fect of glyceryl trinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was evaluated in nine female patients with sphincter of Oddi dy", "tokenized_content": [2, 20557, 1927, 19365, 1033, 24431, 3, 16688, 1031, 1927, 7757, 2199, 23501, 26813, 1990, 1920, 4876, 29043, 2053, 17, 11553, 17, 2719, 20557, 1927, 19365, 1033, 24431, 1982, 3747, 1922, 3]}, "items": [{"id": "p_3634", "content": "Sphincter of Oddi Dysfunction [SEP] Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes ", "score": 1, "type": null, "tokenized_content": [2, 20557, 1927, 19365, 1033, 5273, 3, 6805, 2014, 3183, 9254, 4770, 5884, 1920, 20557, 1927, 19365, 1033, 1930, 2458, 1956, 13210, 5178, 1030, 18, 6598, 2840, 3]}]}
{"query": {"id": "q_3635", "content": "spasm [SEP] rinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was evaluated in nine female patients with sphincter of Oddi dy", "tokenized_content": [2, 24431, 3, 25699, 26813, 1990, 1920, 4876, 29043, 2053, 17, 11553, 17, 2719, 20557, 1927, 19365, 1033, 24431, 1982, 3747, 1922, 6360, 4232, 2132, 1956, 20557, 1927, 19365, 1033, 6433, 3]}, "items": [{"id": "p_3635", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3636", "content": "sphincter of Oddi dyskinesia [SEP] incter of Oddi spasm was evaluated in nine female patients with sphincter of Oddi dyskinesia. METHOD: Sphincter of Oddi spasm was induced by prostigmine-mor", "tokenized_content": [2, 20557, 1927, 19365, 1033, 3890, 26682, 3, 2043, 1967, 1927, 19365, 1033, 24431, 1982, 3747, 1922, 6360, 4232, 2132, 1956, 20557, 1927, 19365, 1033, 3890, 26682, 18, 2417, 30, 20557, 3]}, "items": [{"id": "p_3636", "content": "Sphincter of Oddi Dysfunction [SEP] Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes ", "score": 1, "type": null, "tokenized_content": [2, 20557, 1927, 19365, 1033, 5273, 3, 6805, 2014, 3183, 9254, 4770, 5884, 1920, 20557, 1927, 19365, 1033, 1930, 2458, 1956, 13210, 5178, 1030, 18, 6598, 2840, 3]}]}
{"query": {"id": "q_3637", "content": "Sphincter of Oddi spasm [SEP] nine female patients with sphincter of Oddi dyskinesia. METHOD: Sphincter of Oddi spasm was induced by prostigmine-morphine administration (0.5 mg pros", "tokenized_content": [2, 20557, 1927, 19365, 1033, 24431, 3, 6360, 4232, 2132, 1956, 20557, 1927, 19365, 1033, 3890, 26682, 18, 2417, 30, 20557, 1927, 19365, 1033, 24431, 1982, 2719, 2007, 4876, 29043, 2053, 3]}, "items": [{"id": "p_3637", "content": "Sphincter of Oddi Dysfunction [SEP] Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes ", "score": 1, "type": null, "tokenized_content": [2, 20557, 1927, 19365, 1033, 5273, 3, 6805, 2014, 3183, 9254, 4770, 5884, 1920, 20557, 1927, 19365, 1033, 1930, 2458, 1956, 13210, 5178, 1030, 18, 6598, 2840, 3]}]}
{"query": {"id": "q_3638", "content": "Nitrolingual [SEP] ire procedure was repeated during glyceryl trinitrate infusion (Nitrolingual 1 microg/kg/min for 120 min). RESULTS: Prostigmine-morphine pro", "tokenized_content": [2, 8686, 3961, 2224, 3, 13439, 4360, 1982, 5116, 2409, 7757, 2199, 23501, 26813, 7386, 12, 8686, 3961, 2224, 21, 12517, 19, 3621, 19, 2360, 1958, 6103, 2360, 13, 18, 2274, 3]}, "items": [{"id": "p_3638", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_3639", "content": "Prostigmine [SEP] e infusion (Nitrolingual 1 microg/kg/min for 120 min). RESULTS: Prostigmine-morphine provocation caused significant increases in the time t", "tokenized_content": [2, 4876, 29043, 2053, 3, 47, 7386, 12, 8686, 3961, 2224, 21, 12517, 19, 3621, 19, 2360, 1958, 6103, 2360, 13, 18, 2274, 30, 4876, 29043, 2053, 17, 11553, 2463, 5980, 3]}, "items": [{"id": "p_3639", "content": "Neostigmine [SEP] A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gal", "score": 1, "type": null, "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 1920, 2311, 1927, 3057, 27618, 8572, 12413, 1937, 1930, 1942, 5267, 1920, 2564, 1927, 3760, 7327, 2356, 2427, 1966, 5179, 3]}]}
{"query": {"id": "q_3640", "content": "Glyceryl trinitrate [SEP] icating a complete spasm at the level of the sphincter of Oddi. Glyceryl trinitrate infusion completely normalized the prostigmine-morphine-induced", "tokenized_content": [2, 7757, 2199, 23501, 26813, 3, 14784, 2104, 43, 4080, 24431, 2019, 1920, 2237, 1927, 1920, 20557, 1927, 19365, 1033, 18, 7757, 2199, 23501, 26813, 7386, 5796, 5766, 1920, 4876, 29043, 3]}, "items": [{"id": "p_3640", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_3641", "content": "steroid [SEP] Effects of acute steroid administration on ventilatory and peripheral muscles in rats.", "tokenized_content": [2, 9507, 3, 2564, 1927, 3939, 9507, 4183, 1990, 23875, 1930, 5009, 7848, 1922, 3615, 18, 3]}, "items": [{"id": "p_3641", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3642", "content": "myopathy [SEP] Occasional case reports have shown that acute myopathy may occur in patients treated with massive doses of corticoster", "tokenized_content": [2, 25017, 3, 18838, 3087, 4710, 2162, 2522, 1988, 3939, 25017, 2278, 4704, 1922, 2132, 2868, 1956, 12944, 5312, 1927, 11495, 3]}, "items": [{"id": "p_3642", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3643", "content": "corticosteroids [SEP] te myopathy may occur in patients treated with massive doses of corticosteroids. The mechanism of this myopathy is poorly understood. Therefore", "tokenized_content": [2, 14610, 3, 3602, 25017, 2278, 4704, 1922, 2132, 2868, 1956, 12944, 5312, 1927, 14610, 18, 1920, 2856, 1927, 2052, 25017, 1977, 7865, 7372, 18, 2955, 3]}, "items": [{"id": "p_3643", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_3644", "content": "methylprednisolone [SEP] ere randomly assigned to receive daily injection of saline (C), methylprednisolone (M), or triamcinolone (T) 80 mg/kg/d for 5 d. Nutritional intak", "tokenized_content": [2, 30087, 3, 22561, 6266, 6304, 1942, 7130, 4692, 4107, 1927, 5977, 12, 45, 13, 16, 30087, 12, 55, 13, 16, 2014, 5083, 1976, 3665, 13048, 12, 62, 13, 3729, 2786, 3]}, "items": [{"id": "p_3644", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_3645", "content": "M [SEP] d to receive daily injection of saline (C), methylprednisolone (M), or triamcinolone (T) 80 mg/kg/d for 5 d. Nutritional intake, ", "tokenized_content": [2, 55, 3, 46, 1942, 7130, 4692, 4107, 1927, 5977, 12, 45, 13, 16, 30087, 12, 55, 13, 16, 2014, 5083, 1976, 3665, 13048, 12, 62, 13, 3729, 2786, 19, 3621, 3]}, "items": [{"id": "p_3645", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_3646", "content": "triamcinolone [SEP] ceive daily injection of saline (C), methylprednisolone (M), or triamcinolone (T) 80 mg/kg/d for 5 d. Nutritional intake, measured daily in 1", "tokenized_content": [2, 5083, 1976, 3665, 13048, 3, 5827, 2320, 4692, 4107, 1927, 5977, 12, 45, 13, 16, 30087, 12, 55, 13, 16, 2014, 5083, 1976, 3665, 13048, 12, 62, 13, 3729, 2786, 3]}, "items": [{"id": "p_3646", "content": "Triamcinolone [SEP] A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, o", "score": 1, "type": null, "tokenized_content": [2, 5083, 1976, 3665, 13048, 3, 43, 14469, 3258, 16, 1966, 1920, 3294, 4284, 2014, 1922, 9603, 2828, 2386, 16, 12950, 16, 16774, 1954, 16, 2007, 3076, 4107, 16, 2007, 14728, 16, 57, 3]}]}
{"query": {"id": "q_3647", "content": "T [SEP] ccur in patients treated with massive doses of corticosteroids. The mechanism of this myopathy is poorly understood. Therefore, 6", "tokenized_content": [2, 62, 3, 4928, 1949, 1922, 2132, 2868, 1956, 12944, 5312, 1927, 14610, 18, 1920, 2856, 1927, 2052, 25017, 1977, 7865, 7372, 18, 2955, 16, 26, 3]}, "items": [{"id": "p_3647", "content": "Triamcinolone [SEP] A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, o", "score": 1, "type": null, "tokenized_content": [2, 5083, 1976, 3665, 13048, 3, 43, 14469, 3258, 16, 1966, 1920, 3294, 4284, 2014, 1922, 9603, 2828, 2386, 16, 12950, 16, 16774, 1954, 16, 2007, 3076, 4107, 16, 2007, 14728, 16, 57, 3]}]}
{"query": {"id": "q_3648", "content": "reduction of food intake [SEP] onal intake, measured daily in 15 animals, showed a significant reduction of food intake in the steroid-treated groups (-50 and -79% in M and T, respect", "tokenized_content": [2, 3378, 1927, 3959, 5240, 3, 1990, 1923, 5240, 16, 3045, 4692, 1922, 2461, 3555, 16, 2594, 43, 2228, 3378, 1927, 3959, 5240, 1922, 1920, 9507, 17, 2868, 2671, 12, 17, 3]}, "items": [{"id": "p_3648", "content": "Anorexia [SEP] The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of t", "score": 1, "type": null, "tokenized_content": [2, 21810, 3, 1920, 3630, 2014, 3257, 1927, 17990, 7936, 2007, 1925, 26433, 1942, 3959, 1930, 1920, 11752, 1942, 13619, 18, 2176, 1977, 1920, 11266, 6293, 1927, 62, 3]}]}
{"query": {"id": "q_3649", "content": "steroid [SEP] athy may occur in patients treated with massive doses of corticosteroids. The mechanism of this myopathy is poorly understood. Therefor", "tokenized_content": [2, 9507, 3, 9468, 1012, 2278, 4704, 1922, 2132, 2868, 1956, 12944, 5312, 1927, 14610, 18, 1920, 2856, 1927, 2052, 25017, 1977, 7865, 7372, 18, 2276, 8467, 3]}, "items": [{"id": "p_3649", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3650", "content": "loss in body weight [SEP] % in M and T, respectively). This was associated with a similar loss in body weight. In the 45 remaining animals, diaphragm contractility and histo", "tokenized_content": [2, 3257, 1922, 3362, 3388, 3, 9, 1922, 55, 1930, 62, 16, 2763, 13, 18, 2052, 1982, 2458, 1956, 43, 2551, 3257, 1922, 3362, 3388, 18, 1922, 1920, 3607, 5719, 3555, 3]}, "items": [{"id": "p_3650", "content": "Weight Loss [SEP] Decrease in existing BODY WEIGHT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 3257, 3, 3714, 1922, 6124, 3362, 3388, 18, 3]}]}
{"query": {"id": "q_3651", "content": "tetanic [SEP] oid groups, and time to peak tension was longer with M, whereas tetanic tensions were similar. Steroid treatment also induced a leftwar", "tokenized_content": [2, 9717, 19510, 3, 25166, 1007, 2671, 16, 1930, 2367, 1942, 3833, 10146, 1982, 4872, 1956, 55, 16, 3417, 9717, 19510, 10146, 1036, 1985, 2551, 18, 9507, 2311, 2222, 2719, 43, 3]}, "items": [{"id": "p_3651", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_3652", "content": "Steroid [SEP] nsion was longer with M, whereas tetanic tensions were similar. Steroid treatment also induced a leftward shift of the force-frequency ", "tokenized_content": [2, 9507, 3, 4246, 2001, 1982, 4872, 1956, 55, 16, 3417, 9717, 19510, 10146, 1036, 1985, 2551, 18, 9507, 2311, 2222, 2719, 43, 3506, 3118, 5950, 1927, 1920, 5495, 17, 3528, 3]}, "items": [{"id": "p_3652", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3653", "content": "atrophy [SEP] hragm, scalenus medius, and gastrocnemius showed type IIb fiber atrophy in the steroid groups and also diaphragmatic type IIa atrophy w", "tokenized_content": [2, 10260, 3, 3668, 11431, 16, 3536, 1022, 1957, 2701, 1957, 16, 1930, 23700, 2594, 2601, 19795, 6832, 10260, 1922, 1920, 9507, 2671, 1930, 2222, 29896, 2601, 17433, 10260, 65, 3]}, "items": [{"id": "p_3653", "content": "Muscular Atrophy [SEP] Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, pr", "score": 1, "type": null, "tokenized_content": [2, 12330, 10260, 3, 3135, 9538, 1922, 3081, 1930, 2529, 1927, 3760, 6989, 6966, 1956, 6619, 16, 3378, 1922, 2877, 9042, 16, 2014, 2894, 16704, 16, 2033, 3]}]}
{"query": {"id": "q_3654", "content": "necrosis [SEP] examinations revealed a normal muscular pattern with absence of necrosis. Finally, a pair-fed (PF) study, performed in 18 rats (C, T, an", "tokenized_content": [2, 7476, 3, 10643, 3404, 43, 2791, 12330, 3114, 1956, 3905, 1927, 7476, 18, 4342, 16, 43, 3715, 17, 5788, 12, 5099, 13, 2161, 16, 2593, 1922, 2654, 3615, 12, 45, 3]}, "items": [{"id": "p_3654", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_3655", "content": "muscle atrophy [SEP] ed (PF) study, performed in 18 rats (C, T, and PF), showed that muscle atrophy was considerably less pronounced in PF animals than in T-treate", "tokenized_content": [2, 3760, 10260, 3, 3347, 12, 5099, 13, 2161, 16, 2593, 1922, 2654, 3615, 12, 45, 16, 62, 16, 1930, 5099, 13, 16, 2594, 1988, 3760, 10260, 1982, 9760, 2941, 9079, 3]}, "items": [{"id": "p_3655", "content": "Muscular Atrophy [SEP] Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, pr", "score": 1, "type": null, "tokenized_content": [2, 12330, 10260, 3, 3135, 9538, 1922, 3081, 1930, 2529, 1927, 3760, 6989, 6966, 1956, 6619, 16, 3378, 1922, 2877, 9042, 16, 2014, 2894, 16704, 16, 2033, 3]}]}
{"query": {"id": "q_3656", "content": "steroids [SEP] athy may occur in patients treated with massive doses of corticosteroids. The mechanism of this myopathy is poorly understood. Therefore", "tokenized_content": [2, 13039, 3, 9468, 1012, 2278, 4704, 1922, 2132, 2868, 1956, 12944, 5312, 1927, 14610, 18, 1920, 2856, 1927, 2052, 25017, 1977, 7865, 7372, 18, 2955, 3]}, "items": [{"id": "p_3656", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3657", "content": "atrophy [SEP] hragm, scalenus medius, and gastrocnemius showed type IIb fiber atrophy in the steroid groups and also diaphragmatic type IIa atrophy w", "tokenized_content": [2, 10260, 3, 3668, 11431, 16, 3536, 1022, 1957, 2701, 1957, 16, 1930, 23700, 2594, 2601, 19795, 6832, 10260, 1922, 1920, 9507, 2671, 1930, 2222, 29896, 2601, 17433, 10260, 65, 3]}, "items": [{"id": "p_3657", "content": "Atrophy [SEP] Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as ", "score": 1, "type": null, "tokenized_content": [2, 10260, 3, 3714, 1922, 1920, 3081, 1927, 43, 2024, 16, 2960, 16, 3090, 16, 2014, 3137, 7393, 16, 2458, 1956, 43, 5386, 1927, 6598, 2961, 2427, 1966, 3]}]}
{"query": {"id": "q_3658", "content": "cardiogenic shock [SEP] Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol trea", "tokenized_content": [2, 21129, 11216, 7418, 3, 10923, 21129, 11216, 7418, 1930, 4080, 4003, 3367, 2256, 23300, 4581, 1930, 2130, 17712, 1945, 2171, 1019, 3]}, "items": [{"id": "p_3658", "content": "Shock, Cardiogenic [SEP] Shock resulting from diminution of cardiac output in heart disease.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7418, 16, 21129, 11216, 3, 7418, 3864, 2037, 7798, 2306, 1927, 4435, 6647, 1922, 4003, 2573, 18, 3]}]}
{"query": {"id": "q_3659", "content": "heart block [SEP] Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report.", "tokenized_content": [2, 4003, 3367, 3, 10923, 21129, 11216, 7418, 1930, 4080, 4003, 3367, 2256, 23300, 4581, 1930, 2130, 17712, 1945, 2311, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3659", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_3660", "content": "verapamil [SEP] Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report.", "tokenized_content": [2, 23300, 3, 10923, 21129, 11216, 7418, 1930, 4080, 4003, 3367, 2256, 23300, 4581, 1930, 2130, 17712, 1945, 2311, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3660", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3661", "content": "metoprolol [SEP] rdiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report.", "tokenized_content": [2, 2130, 17712, 1945, 3, 8695, 3940, 11216, 7418, 1930, 4080, 4003, 3367, 2256, 23300, 4581, 1930, 2130, 17712, 1945, 2311, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3661", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_3662", "content": "heart block [SEP] A seventy-eight-year-old woman presented with complete heart block and refractory hypotension two days after a therapeutic dose of", "tokenized_content": [2, 4003, 3367, 3, 43, 16270, 17, 5066, 17, 2476, 17, 4156, 10440, 3549, 1956, 4080, 4003, 3367, 1930, 10923, 16453, 2288, 3000, 2256, 43, 4272, 3253, 1927, 3]}, "items": [{"id": "p_3662", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_3663", "content": "hypotension [SEP] ar-old woman presented with complete heart block and refractory hypotension two days after a therapeutic dose of sustained-release verapami", "tokenized_content": [2, 16453, 3, 2245, 17, 4156, 10440, 3549, 1956, 4080, 4003, 3367, 1930, 10923, 16453, 2288, 3000, 2256, 43, 4272, 3253, 1927, 7637, 17, 4012, 3566, 29398, 7395, 3]}, "items": [{"id": "p_3663", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3664", "content": "verapamil [SEP] otension two days after a therapeutic dose of sustained-release verapamil with concomitant use of metoprolol. The patient continued to re", "tokenized_content": [2, 23300, 3, 7608, 3212, 2288, 3000, 2256, 43, 4272, 3253, 1927, 7637, 17, 4012, 23300, 1956, 8537, 2485, 1927, 2130, 17712, 1945, 18, 1920, 2774, 7583, 1942, 1964, 3]}, "items": [{"id": "p_3664", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3665", "content": "metoprolol [SEP] tic dose of sustained-release verapamil with concomitant use of metoprolol. The patient continued to remain hypotensive with complete hear", "tokenized_content": [2, 2130, 17712, 1945, 3, 18298, 3253, 1927, 7637, 17, 4012, 23300, 1956, 8537, 2485, 1927, 2130, 17712, 1945, 18, 1920, 2774, 7583, 1942, 5555, 12201, 3766, 1956, 4080, 3563, 3]}, "items": [{"id": "p_3665", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_3666", "content": "hypotensive [SEP]  concomitant use of metoprolol. The patient continued to remain hypotensive with complete heart block, even with multiple uses of intraveno", "tokenized_content": [2, 12201, 3766, 3, 8537, 2485, 1927, 2130, 17712, 1945, 18, 1920, 2774, 7583, 1942, 5555, 12201, 3766, 1956, 4080, 4003, 3367, 16, 3385, 1956, 3137, 7947, 1927, 6306, 19824, 3]}, "items": [{"id": "p_3666", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3667", "content": "atropine [SEP] th complete heart block, even with multiple uses of intravenous atropine as well as high doses of pressor agents such as dopamine and do", "tokenized_content": [2, 24031, 3, 1913, 4080, 4003, 3367, 16, 3385, 1956, 3137, 7947, 1927, 7307, 24031, 1966, 2486, 1966, 2149, 5312, 1927, 3477, 1924, 4820, 2427, 1966, 7964, 1930, 2608, 3]}, "items": [{"id": "p_3667", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_3668", "content": "dopamine [SEP] venous atropine as well as high doses of pressor agents such as dopamine and dobutamine. However, shortly after the use of intravenous c", "tokenized_content": [2, 7964, 3, 8562, 24031, 1966, 2486, 1966, 2149, 5312, 1927, 3477, 1924, 4820, 2427, 1966, 7964, 1930, 2608, 16119, 3812, 18, 2406, 16, 17002, 2256, 1920, 2485, 1927, 7307, 45, 3]}, "items": [{"id": "p_3668", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3669", "content": "dobutamine [SEP] ne as well as high doses of pressor agents such as dopamine and dobutamine. However, shortly after the use of intravenous calcium chloride", "tokenized_content": [2, 2608, 16119, 3812, 3, 2069, 1966, 2486, 1966, 2149, 5312, 1927, 3477, 1924, 4820, 2427, 1966, 7964, 1930, 2608, 16119, 3812, 18, 2406, 16, 17002, 2256, 1920, 2485, 1927, 7307, 3]}, "items": [{"id": "p_3669", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_3670", "content": "calcium chloride [SEP] e and dobutamine. However, shortly after the use of intravenous calcium chloride, the refractory hypotension and complete heart block resolved.", "tokenized_content": [2, 5016, 9140, 3, 47, 1930, 2608, 16119, 3812, 18, 2406, 16, 17002, 2256, 1920, 2485, 1927, 7307, 5016, 9140, 16, 1920, 10923, 16453, 1930, 4080, 4003, 3367, 8397, 18, 3]}, "items": [{"id": "p_3670", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_3671", "content": "antipurine [SEP] A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.", "tokenized_content": [2, 2246, 1034, 17687, 3, 43, 3193, 51, 2535, 2161, 1927, 1920, 2246, 1034, 17687, 12244, 8649, 3004, 14578, 13280, 1945, 12, 6758, 2183, 1038, 13, 3258, 1956, 4726, 19731, 2687, 3]}, "items": [{"id": "p_3671", "content": "Antipyrine [SEP] An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of o", "score": 1, "type": null, "tokenized_content": [2, 2246, 18425, 2053, 3, 1925, 14501, 1930, 2246, 18425, 3023, 1988, 2258, 2252, 3258, 2007, 11701, 1930, 1966, 4352, 15867, 18, 2246, 18425, 2053, 1977, 3868, 2251, 1922, 4213, 1920, 2564, 1927, 57, 3]}]}
{"query": {"id": "q_3672", "content": "lometrexol [SEP] A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.", "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 43, 3193, 51, 2535, 2161, 1927, 1920, 2246, 1034, 17687, 12244, 8649, 3004, 14578, 13280, 1945, 12, 6758, 2183, 1038, 13, 3258, 1956, 4726, 19731, 3]}, "items": [{"id": "p_3672", "content": "lometrexol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 3]}]}
{"query": {"id": "q_3673", "content": "DDATHF [SEP] phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.", "tokenized_content": [2, 6758, 2183, 1038, 3, 3193, 51, 2535, 2161, 1927, 1920, 2246, 1034, 17687, 12244, 8649, 3004, 14578, 13280, 1945, 12, 6758, 2183, 1038, 13, 3258, 1956, 4726, 19731, 2687, 18, 3]}, "items": [{"id": "p_3673", "content": "lometrexol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 3]}]}
{"query": {"id": "q_3674", "content": "folic acid [SEP] f the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.", "tokenized_content": [2, 19731, 2687, 3, 48, 1920, 2246, 1034, 17687, 12244, 8649, 3004, 14578, 13280, 1945, 12, 6758, 2183, 1038, 13, 3258, 1956, 4726, 19731, 2687, 18, 3]}, "items": [{"id": "p_3674", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_3675", "content": "Lometrexol [SEP] Lometrexol is an antifolate which inhibits glycinamide ribonucleotide form", "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 3004, 14578, 13280, 1945, 1977, 1925, 12244, 8649, 2154, 7042, 4235, 4058, 16408, 1021, 18347, 4749, 2386, 3]}, "items": [{"id": "p_3675", "content": "lometrexol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 3]}]}
{"query": {"id": "q_3676", "content": "glycinamide ribonucleotide [SEP] Lometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo puri", "tokenized_content": [2, 4235, 4058, 16408, 1021, 18347, 4749, 3, 3004, 14578, 13280, 1945, 1977, 1925, 12244, 8649, 2154, 7042, 4235, 4058, 16408, 1021, 18347, 4749, 29285, 9961, 12, 13139, 2794, 13, 16, 3]}, "items": [{"id": "p_3676", "content": "glycinamide ribonucleotide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4235, 4058, 16408, 1021, 18347, 4749, 3, 3]}]}
{"query": {"id": "q_3677", "content": "purine [SEP] tide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Extensive experimental and limited clinical data hav", "tokenized_content": [2, 19700, 3, 8685, 3695, 29285, 9961, 12, 13139, 2794, 13, 16, 1925, 4113, 4415, 1958, 2028, 9441, 19700, 4271, 18, 6475, 3599, 1930, 3892, 2535, 2230, 25838, 3]}, "items": [{"id": "p_3677", "content": "Purines [SEP] A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADE", "score": 1, "type": null, "tokenized_content": [2, 19700, 1036, 3, 43, 4696, 1927, 27804, 13153, 4300, 1988, 2032, 3425, 1954, 11798, 1922, 4899, 1930, 2032, 3171, 2222, 1966, 19700, 11137, 18, 2611, 3951, 23846, 3]}]}
{"query": {"id": "q_3678", "content": "lometrexol [SEP] xtensive experimental and limited clinical data have shown that lometrexol has activity against tumours which are refractory to other drug", "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 23068, 3766, 3599, 1930, 3892, 2535, 2230, 2162, 2522, 1988, 3004, 14578, 13280, 1945, 2258, 2455, 3316, 9313, 2154, 2032, 10923, 1942, 2303, 2838, 3]}, "items": [{"id": "p_3678", "content": "lometrexol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3004, 14578, 13280, 1945, 3, 3]}]}
{"query": {"id": "q_3679", "content": "tumours [SEP] d clinical data have shown that lometrexol has activity against tumours which are refractory to other drugs, notably methotrexate. Howe", "tokenized_content": [2, 9313, 3, 46, 2535, 2230, 2162, 2522, 1988, 3004, 14578, 13280, 1945, 2258, 2455, 3316, 9313, 2154, 2032, 10923, 1942, 2303, 4195, 16, 7388, 18031, 18, 2307, 1021, 3]}, "items": [{"id": "p_3679", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3680", "content": "methotrexate [SEP] ty against tumours which are refractory to other drugs, notably methotrexate. However, the initial clinical development of lometrexol was cu", "tokenized_content": [2, 18031, 3, 6227, 3316, 9313, 2154, 2032, 10923, 1942, 2303, 4195, 16, 7388, 18031, 18, 2406, 16, 1920, 3754, 2535, 2740, 1927, 3004, 14578, 13280, 1945, 1982, 5480, 3]}, "items": [{"id": "p_3680", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_3681", "content": "toxicities [SEP] as curtailed because of severe and cumulative antiproliferative toxicities. Preclinical murine studies demonstrated that the toxicity of l", "tokenized_content": [2, 15251, 3, 1966, 3580, 11578, 1919, 2882, 1927, 4010, 1930, 8274, 21447, 15251, 18, 10311, 7135, 2351, 3161, 1988, 1920, 5532, 1927, 54, 3]}, "items": [{"id": "p_3681", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3682", "content": "toxicity [SEP] ve toxicities. Preclinical murine studies demonstrated that the toxicity of lometrexol can be prevented by low dose folic acid administr", "tokenized_content": [2, 5532, 3, 3428, 15251, 18, 10311, 7135, 2351, 3161, 1988, 1920, 5532, 1927, 3004, 14578, 13280, 1945, 2112, 1998, 8715, 2007, 2330, 3253, 19731, 2687, 10473, 3]}, "items": [{"id": "p_3682", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3683", "content": "folic acid [SEP] ed that the toxicity of lometrexol can be prevented by low dose folic acid administration, i.e. for 7 days prior to and 7 days following a", "tokenized_content": [2, 19731, 2687, 3, 3347, 1988, 1920, 5532, 1927, 3004, 14578, 13280, 1945, 2112, 1998, 8715, 2007, 2330, 3253, 19731, 2687, 4183, 16, 51, 18, 47, 18, 1958, 27, 3000, 3432, 3]}, "items": [{"id": "p_3683", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_3684", "content": "Thrombocytopenia [SEP] metrexol can be markedly reduced by folic acid supplementation. Thrombocytopenia and mucositis were the major toxicities. There was no clear rel", "tokenized_content": [2, 17100, 3, 2130, 13280, 1945, 2112, 1998, 7686, 3028, 2007, 19731, 2687, 8746, 18, 17100, 1930, 3422, 19976, 1985, 1920, 3044, 15251, 18, 2276, 1982, 2239, 4021, 2139, 3]}, "items": [{"id": "p_3684", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3685", "content": "mucositis [SEP] dly reduced by folic acid supplementation. Thrombocytopenia and mucositis were the major toxicities. There was no clear relationship betw", "tokenized_content": [2, 3422, 19976, 3, 5268, 1012, 3028, 2007, 19731, 2687, 8746, 18, 17100, 1930, 3422, 19976, 1985, 1920, 3044, 15251, 18, 2276, 1982, 2239, 4021, 3303, 2143, 1018, 3]}, "items": [{"id": "p_3685", "content": "Mucositis [SEP] An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vas", "score": 1, "type": null, "tokenized_content": [2, 3422, 19976, 3, 1925, 4531, 1927, 1920, 9680, 1956, 22873, 2014, 12347, 4365, 1941, 15826, 18, 2176, 1977, 4378, 2007, 10260, 1927, 1920, 10364, 8081, 16, 6350, 3]}]}
{"query": {"id": "q_3686", "content": "folate [SEP] Lometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GA", "tokenized_content": [2, 13761, 3, 3004, 14578, 13280, 1945, 1977, 1925, 12244, 8649, 2154, 7042, 4235, 4058, 16408, 1021, 18347, 4749, 29285, 9961, 12, 4357, 3]}, "items": [{"id": "p_3686", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_3687", "content": "cancer [SEP]  facilitate the future evaluation of this class of compounds in cancer therapy.", "tokenized_content": [2, 2539, 3, 6628, 1920, 4115, 4391, 1927, 2052, 2921, 1927, 4300, 1922, 2539, 3181, 18, 3]}, "items": [{"id": "p_3687", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3688", "content": "analgesia [SEP] Involvement of the mu-opiate receptor in peripheral analgesia.", "tokenized_content": [2, 14695, 3, 5668, 1927, 1920, 8975, 17, 27059, 3148, 1922, 5009, 14695, 18, 3]}, "items": [{"id": "p_3688", "content": "Pain Insensitivity, Congenital [SEP] A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent cor", "score": 1, "type": null, "tokenized_content": [2, 3594, 30055, 16, 9901, 3, 43, 4741, 4378, 2007, 2063, 11307, 2055, 1942, 3594, 4281, 1920, 3682, 1942, 7279, 24218, 2037, 2447, 17, 24218, 5458, 18, 7685, 2233, 3]}]}
{"query": {"id": "q_3689", "content": "morphine [SEP] The intradermal injection of mu (morphine, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and morphiceptin), kappa (trans-3", "tokenized_content": [2, 11553, 3, 1920, 18736, 7069, 4107, 1927, 8975, 12, 11553, 16, 9036, 17, 46, 17, 10527, 17, 3376, 17, 2943, 1021, 17, 10422, 17, 3376, 17, 2865, 1930, 3901, 2927, 3]}, "items": [{"id": "p_3689", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3690", "content": "Tyr-D-Ala-Gly-NMe-Phe-Gly-ol [SEP] The intradermal injection of mu (morphine, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and morphiceptin), kappa (trans-3,4-dichloro-N-methyl-N[2-(1-py", "tokenized_content": [2, 9036, 17, 46, 17, 10527, 17, 3376, 17, 2943, 1021, 17, 10422, 17, 3376, 17, 2865, 3, 1920, 18736, 7069, 4107, 1927, 8975, 12, 11553, 16, 9036, 17, 46, 17, 3]}, "items": [{"id": "p_3690", "content": "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- [SEP] An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.\n", "score": 1, "type": null, "tokenized_content": [2, 2066, 29195, 1921, 16, 10527, 12, 22, 13, 17, 17257, 4116, 12, 24, 13, 17, 3376, 12, 25, 13, 17, 3, 1925, 2066, 29195, 1921, 5729, 1988, 9331, 6876, 1942, 1920, 8975, 9384, 3148, 18, 2176, 1977, 2251, 1966, 43, 2322, 1958, 2838, 8828, 3144, 18, 3]}]}
{"query": {"id": "q_3691", "content": "morphiceptin [SEP] mal injection of mu (morphine, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and morphiceptin), kappa (trans-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl) cyclo", "tokenized_content": [2, 3901, 2927, 2410, 1921, 3, 3054, 4107, 1927, 8975, 12, 11553, 16, 9036, 17, 46, 17, 10527, 17, 3376, 17, 2943, 1021, 17, 10422, 17, 3376, 17, 2865, 1930, 3901, 3]}, "items": [{"id": "p_3691", "content": "morphiceptin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3901, 2927, 2410, 1921, 3, 3]}]}
{"query": {"id": "q_3692", "content": "trans-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl) cyclohexyl]benzeneactemide [SEP] orphine, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and morphiceptin), kappa (trans-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl) cyclohexyl]benzeneactemide) and delta ([D-Pen2.5]-enkephalin and [D-Ser2]-[Leu]enkephalin-", "tokenized_content": [2, 2127, 17, 23, 16, 24, 17, 29105, 17, 56, 17, 4963, 17, 56, 37, 22, 17, 12, 21, 17, 23878, 7650, 2199, 13, 22724, 2199, 39, 18536, 2131, 26935, 3, 3]}, "items": [{"id": "p_3692", "content": "3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer [SEP] A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCO", "score": 1, "type": null, "tokenized_content": [2, 23, 16, 24, 17, 29105, 17, 56, 17, 4963, 17, 56, 17, 12, 22, 17, 12, 21, 17, 23878, 7650, 2199, 13, 17, 22724, 2199, 13, 17, 18536, 27457, 16, 12, 2127, 13, 17, 15348, 3, 43, 2447, 17, 4207, 16, 12093, 17, 9384, 3148, 7829, 2154, 2258, 2222, 2252, 2435, 1942, 9084, 1920, 4012, 1927, 7206, 10323, 17306, 12, 7206, 24724, 3]}]}
{"query": {"id": "q_3693", "content": "[D-Pen2.5]-enkephalin [SEP] hyl-N[2-(1-pyrrolidinyl) cyclohexyl]benzeneactemide) and delta ([D-Pen2.5]-enkephalin and [D-Ser2]-[Leu]enkephalin-Thr) selective opioid-agonists, by", "tokenized_content": [2, 37, 46, 17, 4959, 1028, 18, 25, 39, 17, 2066, 29195, 1921, 3, 4527, 1024, 17, 56, 37, 22, 17, 12, 21, 17, 23878, 7650, 2199, 13, 22724, 2199, 39, 3]}, "items": [{"id": "p_3693", "content": "Enkephalin, D-Penicillamine (2,5)- [SEP] A disulfide opioid pentapeptide that selectively binds to the DELTA OPIOID RECEPTOR. It possesses antinociceptive activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 29195, 1921, 16, 46, 17, 25142, 3812, 12, 22, 16, 25, 13, 17, 3, 43, 11830, 9384, 9412, 24010, 1988, 9331, 6876, 1942, 1920, 9649, 9384, 3148, 18, 2176, 14465, 29927, 2455, 18, 3]}]}
{"query": {"id": "q_3694", "content": "[D-Ser2]-[Leu]enkephalin-Thr [SEP] yclohexyl]benzeneactemide) and delta ([D-Pen2.5]-enkephalin and [D-Ser2]-[Leu]enkephalin-Thr) selective opioid-agonists, by themselves, did not significantl", "tokenized_content": [2, 37, 46, 17, 2375, 1028, 39, 17, 37, 10632, 39, 2066, 29195, 1921, 17, 8481, 3, 22386, 6012, 17797, 2199, 39, 18536, 2131, 26935, 13, 1930, 9649, 12, 37, 46, 3]}, "items": [{"id": "p_3694", "content": "enkephalin, Ser(2), Leu(5), Thr(6)- [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2066, 29195, 1921, 16, 2375, 12, 22, 13, 16, 10632, 12, 25, 13, 16, 8481, 12, 26, 13, 17, 3, 3]}]}
{"query": {"id": "q_3695", "content": "prostaglandin E2 [SEP] opioid-agonists, however, produced dose-dependent inhibition of prostaglandin E2-induced hyperalgesia. The analgesic effect of the mu-agonist mo", "tokenized_content": [2, 15900, 6602, 3, 9384, 17, 9849, 16, 2406, 16, 4152, 3253, 17, 3100, 3523, 1927, 15900, 6602, 17, 2719, 21525, 18, 1920, 14501, 2495, 1927, 1920, 8975, 17, 7829, 2661, 3]}, "items": [{"id": "p_3695", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_3696", "content": "hyperalgesia [SEP]  produced dose-dependent inhibition of prostaglandin E2-induced hyperalgesia. The analgesic effect of the mu-agonist morphine was dose-depen", "tokenized_content": [2, 21525, 3, 4152, 3253, 17, 3100, 3523, 1927, 15900, 6602, 17, 2719, 21525, 18, 1920, 14501, 2495, 1927, 1920, 8975, 17, 7829, 11553, 1982, 3253, 17, 2554, 1917, 3]}, "items": [{"id": "p_3696", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_3697", "content": "naloxone [SEP]  of the mu-agonist morphine was dose-dependently antagonized by naloxone and prevented by co-injection of pertussis toxin. Morphine did ", "tokenized_content": [2, 21926, 3, 1927, 1920, 8975, 17, 7829, 11553, 1982, 3253, 17, 19898, 29368, 2007, 21926, 1930, 8715, 2007, 2081, 17, 4107, 1927, 19673, 9165, 18, 11553, 2811, 3]}, "items": [{"id": "p_3697", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_3698", "content": "Morphine [SEP] d by naloxone and prevented by co-injection of pertussis toxin. Morphine did not, however, alter the hyperalgesia induced by 8-bromo cyc", "tokenized_content": [2, 11553, 3, 46, 2007, 21926, 1930, 8715, 2007, 2081, 17, 4107, 1927, 19673, 9165, 18, 11553, 2811, 2084, 16, 2406, 16, 4238, 1920, 21525, 2719, 2007, 28, 17, 21392, 21309, 3]}, "items": [{"id": "p_3698", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3699", "content": "8-bromo cyclic adenosine monophosphate [SEP] n. Morphine did not, however, alter the hyperalgesia induced by 8-bromo cyclic adenosine monophosphate. We conclude that the analgesic action of opioids on the periph", "tokenized_content": [2, 28, 17, 21392, 9821, 10125, 21363, 3, 56, 18, 11553, 2811, 2084, 16, 2406, 16, 4238, 1920, 21525, 2719, 2007, 28, 17, 21392, 9821, 10125, 21363, 18, 2038, 7676, 1988, 3]}, "items": [{"id": "p_3699", "content": "8-Bromo Cyclic Adenosine Monophosphate [SEP] A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation ", "score": 1, "type": null, "tokenized_content": [2, 28, 17, 21392, 9821, 10125, 21363, 3, 43, 2815, 17, 8290, 10533, 1927, 9821, 3681, 18, 2176, 1977, 1925, 9518, 1927, 9821, 3681, 17, 3100, 2213, 4016, 16, 2308, 4910, 1942, 4877, 3]}]}
{"query": {"id": "q_3700", "content": "cyclic adenosine monophosphate [SEP] ine did not, however, alter the hyperalgesia induced by 8-bromo cyclic adenosine monophosphate. We conclude that the analgesic action of opioids on the periph", "tokenized_content": [2, 9821, 10125, 21363, 3, 11116, 2811, 2084, 16, 2406, 16, 4238, 1920, 21525, 2719, 2007, 28, 17, 21392, 9821, 10125, 21363, 18, 2038, 7676, 1988, 1920, 14501, 4615, 1927, 16218, 3]}, "items": [{"id": "p_3700", "content": "Cyclic AMP [SEP] An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. I", "score": 1, "type": null, "tokenized_content": [2, 9821, 3681, 3, 1925, 15643, 5489, 3165, 2340, 5413, 2210, 2154, 1977, 9603, 2828, 1942, 2321, 1920, 23, 11, 17, 1930, 25, 11, 17, 6490, 1927, 1920, 9523, 11804, 18, 51, 3]}]}
{"query": {"id": "q_3701", "content": "ribavirin [SEP] Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy", "tokenized_content": [2, 23635, 3, 7485, 8035, 1927, 23635, 3378, 1922, 2132, 1956, 22409, 2409, 3921, 3181, 3]}, "items": [{"id": "p_3701", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_3702", "content": "hemolysis [SEP] Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chro", "tokenized_content": [2, 22409, 3, 7485, 8035, 1927, 23635, 3378, 1922, 2132, 1956, 22409, 2409, 3921, 3181, 1927, 10001, 1930, 23635, 1958, 8777, 1037, 3]}, "items": [{"id": "p_3702", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_3703", "content": "interferon [SEP] uction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.", "tokenized_content": [2, 10001, 3, 8577, 1929, 1922, 2132, 1956, 22409, 2409, 3921, 3181, 1927, 10001, 1930, 23635, 1958, 3724, 7977, 45, 18, 3]}, "items": [{"id": "p_3703", "content": "Interferons [SEP] Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different v", "score": 1, "type": null, "tokenized_content": [2, 10001, 1036, 3, 2697, 8366, 2007, 13416, 2094, 1922, 2644, 1942, 43, 4743, 5386, 1927, 23329, 18, 2611, 7909, 3554, 3316, 3086, 2413, 64, 3]}]}
{"query": {"id": "q_3704", "content": "chronic hepatitis C [SEP] ysis during combination therapy of interferon and ribavirin for chronic hepatitis C.", "tokenized_content": [2, 3724, 7977, 45, 3, 24018, 1937, 2409, 3921, 3181, 1927, 10001, 1930, 23635, 1958, 3724, 7977, 45, 18, 3]}, "items": [{"id": "p_3704", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_3705", "content": "Hemolytic anemia [SEP] BACKGROUND: Hemolytic anemia is one of the major adverse events of the combination therapy o", "tokenized_content": [2, 21515, 10679, 3, 3872, 30, 21515, 10679, 1977, 2340, 1927, 1920, 3044, 5246, 3916, 1927, 1920, 3921, 3181, 57, 3]}, "items": [{"id": "p_3705", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3706", "content": "interferon [SEP] s one of the major adverse events of the combination therapy of interferon and ribavirin. Because of ribavirin-related hemolytic anemia, d", "tokenized_content": [2, 10001, 3, 61, 2340, 1927, 1920, 3044, 5246, 3916, 1927, 1920, 3921, 3181, 1927, 10001, 1930, 23635, 18, 2882, 1927, 23635, 17, 2712, 21515, 10679, 16, 46, 3]}, "items": [{"id": "p_3706", "content": "Interferons [SEP] Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different v", "score": 1, "type": null, "tokenized_content": [2, 10001, 1036, 3, 2697, 8366, 2007, 13416, 2094, 1922, 2644, 1942, 43, 4743, 5386, 1927, 23329, 18, 2611, 7909, 3554, 3316, 3086, 2413, 64, 3]}]}
{"query": {"id": "q_3707", "content": "ribavirin [SEP] jor adverse events of the combination therapy of interferon and ribavirin. Because of ribavirin-related hemolytic anemia, dose reduction ", "tokenized_content": [2, 23635, 3, 7420, 1005, 5246, 3916, 1927, 1920, 3921, 3181, 1927, 10001, 1930, 23635, 18, 2882, 1927, 23635, 17, 2712, 21515, 10679, 16, 3253, 3378, 3]}, "items": [{"id": "p_3707", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_3708", "content": "hemolytic anemia [SEP] erapy of interferon and ribavirin. Because of ribavirin-related hemolytic anemia, dose reduction is a common event in this therapy. In this clin", "tokenized_content": [2, 21515, 10679, 3, 14821, 13976, 1927, 10001, 1930, 23635, 18, 2882, 1927, 23635, 17, 2712, 21515, 10679, 16, 3253, 3378, 1977, 43, 3059, 4817, 1922, 2052, 3181, 18, 1922, 2052, 3]}, "items": [{"id": "p_3708", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3709", "content": "hemolysis [SEP] ned the suitable timing of ribavirin reduction in patients with hemolysis during combination therapy. METHODS: Thirty-seven of 160 patien", "tokenized_content": [2, 22409, 3, 2069, 1007, 1920, 6947, 8035, 1927, 23635, 3378, 1922, 2132, 1956, 22409, 2409, 3921, 3181, 18, 2860, 30, 9942, 17, 5260, 1927, 9608, 2091, 1917, 3]}, "items": [{"id": "p_3709", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_3710", "content": "anemia [SEP] BACKGROUND: Hemolytic anemia is one of the major adverse events of the combination therapy o", "tokenized_content": [2, 10679, 3, 3872, 30, 21515, 10679, 1977, 2340, 1927, 1920, 3044, 5246, 3916, 1927, 1920, 3921, 3181, 57, 3]}, "items": [{"id": "p_3710", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3711", "content": "puromycin aminonucleoside [SEP] eased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 13832, 1007, 2294, 1930, 8913, 5133, 1927, 4604, 24971, 6991, 1922, 19750, 3835, 1022, 2626, 8028, 17, 2719, 29646, 4741, 1922, 3615, 18, 3]}, "items": [{"id": "p_3711", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_3712", "content": "nephrotic syndrome [SEP] ing of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats.", "tokenized_content": [2, 29646, 4741, 3, 30393, 1927, 4604, 24971, 6991, 1922, 19750, 3835, 1022, 2626, 8028, 17, 2719, 29646, 4741, 1922, 3615, 18, 3]}, "items": [{"id": "p_3712", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3713", "content": "Nephrotic syndrome [SEP] Nephrotic syndrome is often accompanied by sodium retention and generalized edema.", "tokenized_content": [2, 29646, 4741, 3, 29646, 4741, 1977, 3868, 7936, 2007, 5227, 7521, 1930, 9612, 10144, 18, 3]}, "items": [{"id": "p_3713", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3714", "content": "sodium [SEP] Nephrotic syndrome is often accompanied by sodium retention and generalized edema. However, the molecular basis f", "tokenized_content": [2, 5227, 3, 29646, 4741, 1977, 3868, 7936, 2007, 5227, 7521, 1930, 9612, 10144, 18, 2406, 16, 1920, 3272, 4859, 48, 3]}, "items": [{"id": "p_3714", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3715", "content": "edema [SEP] ndrome is often accompanied by sodium retention and generalized edema. However, the molecular basis for the decreased renal sodium ex", "tokenized_content": [2, 10144, 3, 26990, 2225, 1977, 3868, 7936, 2007, 5227, 7521, 1930, 9612, 10144, 18, 2406, 16, 1920, 3272, 4859, 1958, 1920, 3261, 4604, 5227, 1975, 3]}, "items": [{"id": "p_3715", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_3716", "content": "Na [SEP] um excretion remains undefined. We hypothesized that epithelial Na channel (ENaC) subunit dysregulation may be responsible for the", "tokenized_content": [2, 4049, 3, 8736, 11093, 4497, 26687, 18, 2038, 7149, 1988, 4944, 4049, 4999, 12, 24971, 13, 5903, 12908, 2278, 1998, 5061, 1958, 1920, 3]}, "items": [{"id": "p_3716", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3717", "content": "puromycin aminonucleoside [SEP] odium retention. An experimental group of rats was treated with puromycin aminonucleoside (PAN; 180 mg/kg iv), whereas the control group received only ve", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 4426, 2457, 7521, 18, 1925, 3599, 2210, 1927, 3615, 1982, 2868, 1956, 19750, 3835, 1022, 2626, 8028, 12, 3797, 31, 8585, 2786, 19, 3621, 3]}, "items": [{"id": "p_3717", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_3718", "content": "PAN [SEP] ental group of rats was treated with puromycin aminonucleoside (PAN; 180 mg/kg iv), whereas the control group received only vehicle", "tokenized_content": [2, 3797, 3, 8496, 1923, 2210, 1927, 3615, 1982, 2868, 1956, 19750, 3835, 1022, 2626, 8028, 12, 3797, 31, 8585, 2786, 19, 3621, 4370, 13, 16, 3417, 1920, 2285, 2210, 4004, 3]}, "items": [{"id": "p_3718", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_3719", "content": "proteinuria [SEP] d only vehicle. After 7 days, PAN treatment induced significant proteinuria, hypoalbuminemia, decreased urinary sodium excretion, and exten", "tokenized_content": [2, 15831, 3, 46, 2444, 6463, 18, 2256, 27, 3000, 16, 3797, 2311, 2719, 2228, 15831, 16, 14395, 15721, 3847, 16, 3261, 7075, 5227, 11093, 16, 1930, 11899, 3]}, "items": [{"id": "p_3719", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_3720", "content": "hypoalbuminemia [SEP] e. After 7 days, PAN treatment induced significant proteinuria, hypoalbuminemia, decreased urinary sodium excretion, and extensive ascites. The", "tokenized_content": [2, 14395, 15721, 3847, 3, 47, 18, 2256, 27, 3000, 16, 3797, 2311, 2719, 2228, 15831, 16, 14395, 15721, 3847, 16, 3261, 7075, 5227, 11093, 16, 1930, 6475, 17622, 18, 1920, 3]}, "items": [{"id": "p_3720", "content": "Hypoalbuminemia [SEP] A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased h", "score": 1, "type": null, "tokenized_content": [2, 14395, 15721, 3847, 3, 43, 2625, 1922, 2154, 7712, 2237, 1922, 2877, 12, 3256, 7712, 13, 1977, 4535, 1920, 2791, 3109, 18, 14395, 15721, 3847, 2278, 1998, 2810, 1942, 3261, 50, 3]}]}
{"query": {"id": "q_3721", "content": "ascites [SEP] oalbuminemia, decreased urinary sodium excretion, and extensive ascites. The protein abundance of alpha-ENaC and beta-ENaC was increase", "tokenized_content": [2, 17622, 3, 8965, 1024, 14309, 3847, 16, 3261, 7075, 5227, 11093, 16, 1930, 6475, 17622, 18, 1920, 2213, 6232, 1927, 4595, 17, 24971, 1930, 4666, 17, 24971, 1982, 2760, 3]}, "items": [{"id": "p_3721", "content": "Ascites [SEP] Accumulation or retention of free fluid within the peritoneal cavity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17622, 3, 4858, 2014, 7521, 1927, 3294, 5466, 2651, 1920, 10706, 8568, 18, 3]}]}
{"query": {"id": "q_3722", "content": "H [SEP] is often accompanied by sodium retention and generalized edema. However, the molecular basis for the decreased renal sodium excre", "tokenized_content": [2, 50, 3, 1977, 3868, 7936, 2007, 5227, 7521, 1930, 9612, 10144, 18, 2406, 16, 1920, 3272, 4859, 1958, 1920, 3261, 4604, 5227, 9394, 3]}, "items": [{"id": "p_3722", "content": "Hydrogen [SEP] The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.008", "score": 1, "type": null, "tokenized_content": [2, 6201, 3, 1920, 2561, 4399, 6149, 1922, 1920, 12922, 2545, 18, 2176, 2258, 1920, 11241, 17530, 50, 16, 11241, 2529, 21, 16, 1930, 11241, 3388, 37, 21, 18, 13298, 11068, 31, 21, 18, 13587, 3]}]}
{"query": {"id": "q_3723", "content": "K [SEP] protein abundances of Na(+)/H(+) exchanger type 3 (NHE3), Na(+)-K(+)-2Cl(-) cotransporter (BSC-1), and thiazide-sensitive Na(+)-C", "tokenized_content": [2, 53, 3, 2213, 16853, 1927, 4049, 12, 15, 13, 19, 50, 12, 15, 13, 27419, 2601, 23, 12, 13959, 1010, 13, 16, 4049, 12, 15, 13, 17, 53, 12, 15, 3]}, "items": [{"id": "p_3723", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_3724", "content": "Cl [SEP] n abundances of Na(+)/H(+) exchanger type 3 (NHE3), Na(+)-K(+)-2Cl(-) cotransporter (BSC-1), and thiazide-sensitive Na(+)-Cl(-) co", "tokenized_content": [2, 2111, 3, 56, 16853, 1927, 4049, 12, 15, 13, 19, 50, 12, 15, 13, 27419, 2601, 23, 12, 13959, 1010, 13, 16, 4049, 12, 15, 13, 17, 53, 12, 15, 3]}, "items": [{"id": "p_3724", "content": "Chlorine [SEP] A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 1", "score": 1, "type": null, "tokenized_content": [2, 25732, 3, 43, 4524, 2471, 17, 7463, 16, 24149, 3264, 4422, 1988, 1977, 43, 7210, 1927, 1920, 24778, 3416, 1927, 5362, 18, 2176, 2258, 1920, 11241, 17530, 2111, 16, 11241, 2529, 21, 3]}]}
{"query": {"id": "q_3725", "content": "thiazide [SEP] ger type 3 (NHE3), Na(+)-K(+)-2Cl(-) cotransporter (BSC-1), and thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) were decreased. Moreo", "tokenized_content": [2, 27225, 2261, 3, 9559, 2601, 23, 12, 13959, 1010, 13, 16, 4049, 12, 15, 13, 17, 53, 12, 15, 13, 17, 6921, 1024, 12, 17, 13, 14817, 24095, 12, 8242, 3]}, "items": [{"id": "p_3725", "content": "Thiazides [SEP] Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SOD", "score": 1, "type": null, "tokenized_content": [2, 27225, 3726, 3, 27804, 13153, 4300, 1956, 12585, 1930, 6634, 1922, 1920, 6335, 18, 2052, 2576, 5384, 11238, 1942, 1920, 19225, 22523, 2713, 10119, 1036, 1988, 2875, 4546, 3]}]}
{"query": {"id": "q_3726", "content": "nephrotic syndrome [SEP] play a role in the sodium retention associated with PAN-induced nephrotic syndrome. The decreased abundance of NHE3, BSC-1, TSC, and Na-K-ATPase m", "tokenized_content": [2, 29646, 4741, 3, 3918, 43, 2770, 1922, 1920, 5227, 7521, 2458, 1956, 3797, 17, 2719, 29646, 4741, 18, 1920, 3261, 6232, 1927, 13959, 1010, 16, 8242, 1030, 17, 21, 16, 3]}, "items": [{"id": "p_3726", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3727", "content": "breast cancer [SEP] Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot stud", "tokenized_content": [2, 3739, 2539, 3, 3731, 6365, 3181, 1958, 1920, 2311, 1927, 3739, 2539, 2162, 43, 13052, 2495, 1990, 4525, 1930, 10032, 35, 43, 9404, 2060, 3]}, "items": [{"id": "p_3727", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3728", "content": "detrimental effect on memory [SEP] Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study.", "tokenized_content": [2, 13052, 2495, 1990, 4525, 3, 3731, 6365, 3181, 1958, 1920, 2311, 1927, 3739, 2539, 2162, 43, 13052, 2495, 1990, 4525, 1930, 10032, 35, 43, 9404, 2161, 18, 3]}, "items": [{"id": "p_3728", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_3729", "content": "breast cancer [SEP] This pilot study examines whether hormone therapy for breast cancer affects cognition. Patients participating in a randomised trial", "tokenized_content": [2, 3739, 2539, 3, 2052, 9404, 2161, 17910, 3053, 6365, 3181, 1958, 3739, 2539, 6886, 10032, 18, 2132, 9505, 1922, 43, 12090, 3046, 3]}, "items": [{"id": "p_3729", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_3730", "content": "anastrozole [SEP] ects cognition. Patients participating in a randomised trial of anastrozole, tamoxifen alone or combined (ATAC) (n=94) and a group of women", "tokenized_content": [2, 12263, 27927, 3, 7495, 1036, 10032, 18, 2132, 9505, 1922, 43, 12090, 3046, 1927, 12263, 27927, 16, 13011, 4298, 2014, 4252, 12, 27382, 1030, 13, 12, 56, 33, 5650, 13, 3]}, "items": [{"id": "p_3730", "content": "anastrozole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12263, 27927, 3, 3]}]}
{"query": {"id": "q_3731", "content": "tamoxifen [SEP] n. Patients participating in a randomised trial of anastrozole, tamoxifen alone or combined (ATAC) (n=94) and a group of women without br", "tokenized_content": [2, 13011, 3, 56, 18, 2132, 9505, 1922, 43, 12090, 3046, 1927, 12263, 27927, 16, 13011, 4298, 2014, 4252, 12, 27382, 1030, 13, 12, 56, 33, 5650, 13, 1930, 43, 2210, 3]}, "items": [{"id": "p_3731", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_3732", "content": "oestrogen [SEP] cancer. Verbal memory may be especially sensitive to changes in oestrogen levels, a finding commonly reported in studies of hormone repla", "tokenized_content": [2, 26266, 3, 2539, 18, 10011, 4525, 2278, 1998, 4369, 4532, 1942, 2840, 1922, 26266, 2428, 16, 43, 2849, 5384, 2568, 1922, 2351, 1927, 6365, 4856, 1019, 3]}, "items": [{"id": "p_3732", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_3733", "content": "nitric oxide [SEP] Association of nitric oxide production and apoptosis in a model of experimental nephropathy", "tokenized_content": [2, 10233, 7491, 3, 3279, 1927, 10233, 7491, 3372, 1930, 4091, 1922, 43, 2322, 1927, 3599, 15582, 3]}, "items": [{"id": "p_3733", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_3734", "content": "nephropathy [SEP] itric oxide production and apoptosis in a model of experimental nephropathy.", "tokenized_content": [2, 15582, 3, 25096, 1935, 7491, 3372, 1930, 4091, 1922, 43, 2322, 1927, 3599, 15582, 18, 3]}, "items": [{"id": "p_3734", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3735", "content": "nitric oxide [SEP] BACKGROUND: In recent studies increased amounts of nitric oxide (NO) and apoptosis have been implicated in various pathological", "tokenized_content": [2, 10233, 7491, 3, 3872, 30, 1922, 3505, 2351, 2502, 6222, 1927, 10233, 7491, 12, 2239, 13, 1930, 4091, 2162, 2252, 6835, 1922, 3425, 6598, 3]}, "items": [{"id": "p_3735", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_3736", "content": "NO [SEP] ACKGROUND: In recent studies increased amounts of nitric oxide (NO) and apoptosis have been implicated in various pathological con", "tokenized_content": [2, 2239, 3, 2000, 23254, 3049, 30, 1922, 3505, 2351, 2502, 6222, 1927, 10233, 7491, 12, 2239, 13, 1930, 4091, 2162, 2252, 6835, 1922, 3425, 6598, 1962, 3]}, "items": [{"id": "p_3736", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_3737", "content": "nephrotic syndrome [SEP]  and its association with apoptosis in an experimental model of nephrotic syndrome induced by a single injection of adriamycin (ADR). METHODS: The", "tokenized_content": [2, 29646, 4741, 3, 1930, 2496, 3279, 1956, 4091, 1922, 1925, 3599, 2322, 1927, 29646, 4741, 2719, 2007, 43, 2957, 4107, 1927, 25622, 7898, 12, 17645, 13, 18, 2860, 30, 1920, 3]}, "items": [{"id": "p_3737", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3738", "content": "adriamycin [SEP] al model of nephrotic syndrome induced by a single injection of adriamycin (ADR). METHODS: The alteration in the NO pathway was assessed b", "tokenized_content": [2, 25622, 7898, 3, 1969, 2322, 1927, 29646, 4741, 2719, 2007, 43, 2957, 4107, 1927, 25622, 7898, 12, 17645, 13, 18, 2860, 30, 1920, 10076, 1922, 1920, 2239, 3374, 1982, 3683, 3]}, "items": [{"id": "p_3738", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3739", "content": "ADR [SEP] nephrotic syndrome induced by a single injection of adriamycin (ADR). METHODS: The alteration in the NO pathway was assessed by mea", "tokenized_content": [2, 17645, 3, 29646, 4741, 2719, 2007, 43, 2957, 4107, 1927, 25622, 7898, 12, 17645, 13, 18, 2860, 30, 1920, 10076, 1922, 1920, 2239, 3374, 1982, 3683, 2007, 26825, 3]}, "items": [{"id": "p_3739", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3740", "content": "nitrite [SEP] ODS: The alteration in the NO pathway was assessed by measuring nitrite levels in serum/urine and by evaluating the changes in vascular", "tokenized_content": [2, 15988, 3, 4426, 1036, 30, 1920, 10076, 1922, 1920, 2239, 3374, 1982, 3683, 2007, 6711, 15988, 2428, 1922, 3256, 19, 6960, 1930, 2007, 8211, 1920, 2840, 1922, 4541, 3]}, "items": [{"id": "p_3740", "content": "Nitrites [SEP] Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all in", "score": 1, "type": null, "tokenized_content": [2, 15988, 1036, 3, 16028, 1927, 8686, 1957, 2687, 2014, 4300, 3165, 1920, 2210, 19537, 17, 18, 1920, 13849, 15988, 1036, 1927, 1920, 2601, 5890, 5265, 12, 2597, 55, 33, 6048, 13, 2032, 2136, 1922, 3]}]}
{"query": {"id": "q_3741", "content": "nephropathy [SEP] ystem. Rats were stratified into control groups and ADR-induced nephropathy groups. These two groups were then divided into: group 1, anima", "tokenized_content": [2, 15582, 3, 24018, 2057, 1035, 18, 3615, 1985, 9536, 2460, 2285, 2671, 1930, 17645, 17, 2719, 15582, 2671, 18, 2144, 2288, 2671, 1985, 2759, 5831, 2460, 30, 2210, 21, 16, 3]}, "items": [{"id": "p_3741", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3742", "content": "aminoguanidine [SEP] oup 1, animals receiving saline; and group 2, animals receiving aminoguanidine (AG) which is a specific inhibitor of inducible-NO synthase. On", "tokenized_content": [2, 3835, 11056, 8150, 27099, 3, 17208, 1034, 21, 16, 3555, 5962, 5977, 31, 1930, 2210, 22, 16, 3555, 5962, 3835, 11056, 8150, 27099, 12, 2260, 13, 2154, 1977, 43, 2487, 3]}, "items": [{"id": "p_3742", "content": "pimagedine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17019, 4555, 2053, 3, 3]}]}
{"query": {"id": "q_3743", "content": "AG [SEP] eceiving saline; and group 2, animals receiving aminoguanidine (AG) which is a specific inhibitor of inducible-NO synthase. On day", "tokenized_content": [2, 2260, 3, 3270, 14209, 3141, 5977, 31, 1930, 2210, 22, 16, 3555, 5962, 3835, 11056, 8150, 27099, 12, 2260, 13, 2154, 1977, 43, 2487, 4106, 1927, 9376, 17, 2239, 8921, 3]}, "items": [{"id": "p_3743", "content": "pimagedine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17019, 4555, 2053, 3, 3]}]}
{"query": {"id": "q_3744", "content": "mesangial proliferation [SEP] of the kidneys of rats treated with ADR revealed focal areas of mesangial proliferation and mild tubulointerstitial inflammation. They also had signifi", "tokenized_content": [2, 24310, 4031, 3, 1927, 1920, 11770, 1927, 3615, 2868, 1956, 17645, 3404, 8083, 3957, 1927, 24310, 4031, 1930, 5809, 25860, 4418, 2045, 2572, 2086, 4531, 18, 2611, 2222, 2430, 2105, 3]}, "items": [{"id": "p_3744", "content": "Mesangial sclerosis, diffuse [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24310, 11484, 16, 9435, 3, 3]}]}
{"query": {"id": "q_3745", "content": "tubulointerstitial inflammation [SEP] th ADR revealed focal areas of mesangial proliferation and mild tubulointerstitial inflammation. They also had significantly higher levels of proteinuria compa", "tokenized_content": [2, 25860, 4418, 2045, 2572, 2086, 4531, 3, 1913, 17645, 3404, 8083, 3957, 1927, 24310, 4031, 1930, 5809, 25860, 4418, 2045, 2572, 2086, 4531, 18, 2611, 2222, 2430, 2567, 2580, 2428, 3]}, "items": [{"id": "p_3745", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_3746", "content": "proteinuria [SEP] tial inflammation. They also had significantly higher levels of proteinuria compared with control and treatment groups (P < 0.05). Urine ni", "tokenized_content": [2, 15831, 3, 22093, 1024, 4531, 18, 2611, 2222, 2430, 2567, 2580, 2428, 1927, 15831, 2452, 1956, 2285, 1930, 2311, 2671, 12, 58, 32, 20, 18, 2914, 13, 18, 6960, 7781, 3]}, "items": [{"id": "p_3746", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_3747", "content": "phenylephrine [SEP]  increased in the ADR-nephropathy group (P < 0.05). In the IPRK phenylephrine and acetylcholine related responses were significantly impaired", "tokenized_content": [2, 27053, 3, 2502, 1922, 1920, 17645, 17, 15582, 2210, 12, 58, 32, 20, 18, 2914, 13, 18, 1922, 1920, 27194, 1040, 27053, 1930, 14561, 2712, 3387, 1985, 2567, 5761, 3]}, "items": [{"id": "p_3747", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_3748", "content": "acetylcholine [SEP] ADR-nephropathy group (P < 0.05). In the IPRK phenylephrine and acetylcholine related responses were significantly impaired in the ADR-nephro", "tokenized_content": [2, 14561, 3, 17645, 17, 15582, 2210, 12, 58, 32, 20, 18, 2914, 13, 18, 1922, 1920, 27194, 1040, 27053, 1930, 14561, 2712, 3387, 1985, 2567, 5761, 1922, 1920, 17645, 17, 3]}, "items": [{"id": "p_3748", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_3749", "content": "nephrosis [SEP]  apoptosis are important in the pathogenesis of the ADR-induced nephrosis.", "tokenized_content": [2, 7737, 4870, 3, 4091, 2032, 2715, 1922, 1920, 6559, 1927, 1920, 17645, 17, 2719, 7737, 4870, 18, 3]}, "items": [{"id": "p_3749", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_3750", "content": "carteolol hydrochloride [SEP] The attenuating effect of carteolol hydrochloride, a beta-adrenoceptor antagonist, on neuroleptic-induced catalep", "tokenized_content": [2, 17302, 1021, 23646, 16675, 3, 1920, 23074, 2495, 1927, 17302, 1021, 23646, 16675, 16, 43, 4666, 17, 25090, 8151, 16, 1990, 20325, 17920, 17, 2719, 4233, 2128, 3]}, "items": [{"id": "p_3750", "content": "Carteolol [SEP] A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglauc", "score": 1, "type": null, "tokenized_content": [2, 17302, 1021, 23646, 3, 43, 4666, 17, 13672, 8151, 2251, 1966, 1925, 2246, 17, 18346, 5899, 16, 1925, 2246, 17, 16961, 5899, 16, 1925, 16439, 5899, 16, 1930, 1925, 2246, 4365, 10284, 3]}]}
{"query": {"id": "q_3751", "content": "catalepsy [SEP] hloride, a beta-adrenoceptor antagonist, on neuroleptic-induced catalepsy in rats.", "tokenized_content": [2, 4233, 9431, 1012, 3, 8429, 29189, 16, 43, 4666, 17, 25090, 8151, 16, 1990, 20325, 17920, 17, 2719, 4233, 9431, 1012, 1922, 3615, 18, 3]}, "items": [{"id": "p_3751", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_3752", "content": "akathisia [SEP] beta-adrenoceptor antagonists are effective in the treatment of akathisia, one of the extrapyramidal side effects that occur during neuro", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 4666, 17, 25090, 10515, 2032, 3655, 1922, 1920, 2311, 1927, 4464, 2183, 1937, 2126, 16, 2340, 1927, 1920, 21346, 3553, 25238, 1923, 4159, 2564, 1988, 3]}, "items": [{"id": "p_3752", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_3753", "content": "catalepsy [SEP] ts that occur during neuroleptic treatment. Neuroleptic-induced catalepsy, a model of neuroleptic-induced extrapyramidal side effects, wa", "tokenized_content": [2, 4233, 9431, 1012, 3, 4894, 1988, 4704, 2409, 20325, 17920, 2311, 18, 20325, 17920, 17, 2719, 4233, 9431, 1012, 16, 43, 2322, 1927, 20325, 17920, 17, 2719, 21346, 3553, 25238, 3]}, "items": [{"id": "p_3753", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_3754", "content": "carteolol [SEP] st for neuroleptic-induced akathisia. Therefore, the effects of carteolol, a beta-adrenoceptor antagonist, on haloperidol-induced catalep", "tokenized_content": [2, 17302, 1021, 23646, 3, 1955, 1958, 20325, 17920, 17, 2719, 4464, 2183, 1937, 2126, 18, 2955, 16, 1920, 2564, 1927, 17302, 1021, 23646, 16, 43, 4666, 17, 25090, 8151, 16, 3]}, "items": [{"id": "p_3754", "content": "Carteolol [SEP] A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglauc", "score": 1, "type": null, "tokenized_content": [2, 17302, 1021, 23646, 3, 43, 4666, 17, 13672, 8151, 2251, 1966, 1925, 2246, 17, 18346, 5899, 16, 1925, 2246, 17, 16961, 5899, 16, 1925, 16439, 5899, 16, 1930, 1925, 2246, 4365, 10284, 3]}]}
{"query": {"id": "q_3755", "content": "haloperidol [SEP] e, the effects of carteolol, a beta-adrenoceptor antagonist, on haloperidol-induced catalepsy in rats were behaviorally studied and compare", "tokenized_content": [2, 25107, 3, 47, 16, 1920, 2564, 1927, 17302, 1021, 23646, 16, 43, 4666, 17, 25090, 8151, 16, 1990, 25107, 17, 2719, 4233, 9431, 1012, 1922, 3615, 1985, 5343, 1954, 3942, 3]}, "items": [{"id": "p_3755", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3756", "content": "propranolol [SEP] sy in rats were behaviorally studied and compared with those of propranolol and biperiden, a muscarinic receptor antagonist. Carteolol, as ", "tokenized_content": [2, 21395, 3, 7930, 1922, 3615, 1985, 5343, 1954, 3942, 1930, 2452, 1956, 2690, 1927, 21395, 1930, 8446, 18842, 5233, 16, 43, 20318, 3148, 8151, 18, 17302, 1021, 23646, 16, 1966, 3]}, "items": [{"id": "p_3756", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_3757", "content": "biperiden [SEP] behaviorally studied and compared with those of propranolol and biperiden, a muscarinic receptor antagonist. Carteolol, as well as propra", "tokenized_content": [2, 8446, 18842, 5233, 3, 5343, 1954, 3942, 1930, 2452, 1956, 2690, 1927, 21395, 1930, 8446, 18842, 5233, 16, 43, 20318, 3148, 8151, 18, 17302, 1021, 23646, 16, 1966, 2486, 1966, 3]}, "items": [{"id": "p_3757", "content": "Biperiden [SEP] A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment o", "score": 1, "type": null, "tokenized_content": [2, 8446, 18842, 5233, 3, 43, 20318, 8151, 1988, 2258, 2564, 1922, 2321, 1920, 4101, 1930, 5009, 7580, 3771, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 57, 3]}]}
{"query": {"id": "q_3758", "content": "Carteolol [SEP] of propranolol and biperiden, a muscarinic receptor antagonist. Carteolol, as well as propranolol and biperiden, inhibited the haloperido", "tokenized_content": [2, 17302, 1021, 23646, 3, 1927, 21395, 1930, 8446, 18842, 5233, 16, 43, 20318, 3148, 8151, 18, 17302, 1021, 23646, 16, 1966, 2486, 1966, 21395, 1930, 8446, 18842, 5233, 16, 5069, 3]}, "items": [{"id": "p_3758", "content": "Carteolol [SEP] A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglauc", "score": 1, "type": null, "tokenized_content": [2, 17302, 1021, 23646, 3, 43, 4666, 17, 13672, 8151, 2251, 1966, 1925, 2246, 17, 18346, 5899, 16, 1925, 2246, 17, 16961, 5899, 16, 1925, 16439, 5899, 16, 1930, 1925, 2246, 4365, 10284, 3]}]}
{"query": {"id": "q_3759", "content": "dopamine [SEP] er than that of biperiden. Carteolol did not evoke postsynaptic dopamine receptor-stimulating behavioral signs such as stereotypy and hy", "tokenized_content": [2, 7964, 3, 2668, 2254, 1988, 1927, 8446, 18842, 5233, 18, 17302, 1021, 23646, 2811, 2084, 24074, 13090, 7964, 3148, 17, 9868, 5343, 6879, 2427, 1966, 18028, 2085, 1012, 1930, 4527, 3]}, "items": [{"id": "p_3759", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3760", "content": "hyperlocomotion [SEP] ne receptor-stimulating behavioral signs such as stereotypy and hyperlocomotion in rats. Carteolol did not antagonize the inhibitory effects of", "tokenized_content": [2, 4194, 6012, 13055, 13323, 1916, 3, 2069, 3148, 17, 9868, 5343, 6879, 2427, 1966, 18028, 2085, 1012, 1930, 4194, 6012, 13055, 13323, 1916, 1922, 3615, 18, 17302, 1021, 23646, 2811, 3]}, "items": [{"id": "p_3760", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_3761", "content": "apomorphine [SEP] lol did not antagonize the inhibitory effects of haloperidol on apomorphine-induced stereotypy and locomotor activity in rats. In addition,", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 3004, 1024, 2811, 2084, 28104, 1920, 5431, 2564, 1927, 25107, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 18028, 2085, 1012, 1930, 13594, 2455, 3]}, "items": [{"id": "p_3761", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_3762", "content": "5-hydroxytryptophan [SEP] h as flat body posture and forepaw treading and did not inhibit 5-hydroxytryptophan-induced head twitch in rats. Finally, carteolol did not inhibit", "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 50, 1966, 9778, 3362, 17858, 1930, 9023, 4302, 1018, 2171, 12327, 1930, 2811, 2084, 2875, 25, 17, 8275, 30298, 2688, 1928, 17, 2719, 3]}, "items": [{"id": "p_3762", "content": "5-Hydroxytryptophan [SEP] The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.\n   ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 1920, 8426, 7897, 1922, 1920, 8132, 1927, 11153, 2037, 13489, 18, 2176, 1977, 2251, 1966, 1925, 29132, 1930, 14183, 18, 3]}]}
{"query": {"id": "q_3763", "content": "physostigmine [SEP] induced head twitch in rats. Finally, carteolol did not inhibit physostigmine-induced lethality in rats. These results strongly suggest that ", "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 2719, 4469, 21596, 1922, 3615, 18, 4342, 16, 17302, 1021, 23646, 2811, 2084, 2875, 2861, 2259, 29043, 2053, 17, 2719, 15400, 1922, 3615, 18, 2144, 3]}, "items": [{"id": "p_3763", "content": "Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c", "score": 1, "type": null, "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 6221, 14504, 2596, 5726, 18, 2176, 2112, 1998, 3730, 12259, 1954, 1942, 1920, 16911, 1019, 18, 2176, 2222, 45, 3]}]}
{"query": {"id": "q_3764", "content": "Penicillamine [SEP] Penicillamine-induced rapidly progressive glomerulonephritis in a patient wit", "tokenized_content": [2, 25142, 3812, 3, 25142, 3812, 17, 2719, 6221, 7529, 27057, 1922, 43, 2774, 16086, 3]}, "items": [{"id": "p_3764", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3765", "content": "glomerulonephritis [SEP] Penicillamine-induced rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis.", "tokenized_content": [2, 27057, 3, 25142, 3812, 17, 2719, 6221, 7529, 27057, 1922, 43, 2774, 1956, 13053, 8884, 18, 3]}, "items": [{"id": "p_3765", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_3766", "content": "rheumatoid arthritis [SEP] nduced rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis.", "tokenized_content": [2, 13053, 8884, 3, 8026, 2418, 6221, 7529, 27057, 1922, 43, 2774, 1956, 13053, 8884, 18, 3]}, "items": [{"id": "p_3766", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_3767", "content": "rheumatoid arthritis [SEP] A 67-year-old woman with rheumatoid arthritis presented rapidly progressive glomerulonephritis (RPGN) after 5", "tokenized_content": [2, 13053, 8884, 3, 43, 4838, 17, 2476, 17, 4156, 10440, 1956, 13053, 8884, 3549, 6221, 7529, 27057, 12, 4822, 3223, 13, 2256, 25, 3]}, "items": [{"id": "p_3767", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_3768", "content": "glomerulonephritis [SEP] d woman with rheumatoid arthritis presented rapidly progressive glomerulonephritis (RPGN) after 5 months of D-penicillamine (250 mg/day) treatment", "tokenized_content": [2, 27057, 3, 46, 10440, 1956, 13053, 8884, 3549, 6221, 7529, 27057, 12, 4822, 3223, 13, 2256, 25, 3221, 1927, 46, 17, 25142, 3812, 12, 6330, 2786, 19, 3007, 13, 2311, 3]}, "items": [{"id": "p_3768", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_3769", "content": "RPGN [SEP] oid arthritis presented rapidly progressive glomerulonephritis (RPGN) after 5 months of D-penicillamine (250 mg/day) treatment. Ligh", "tokenized_content": [2, 4822, 3223, 3, 25166, 1007, 8884, 3549, 6221, 7529, 27057, 12, 4822, 3223, 13, 2256, 25, 3221, 1927, 46, 17, 25142, 3812, 12, 6330, 2786, 19, 3007, 13, 2311, 18, 3]}, "items": [{"id": "p_3769", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_3770", "content": "D-penicillamine [SEP] rapidly progressive glomerulonephritis (RPGN) after 5 months of D-penicillamine (250 mg/day) treatment. Light microscopy study showed severe gl", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 6221, 7529, 27057, 12, 4822, 3223, 13, 2256, 25, 3221, 1927, 46, 17, 25142, 3812, 12, 6330, 2786, 19, 3007, 13, 2311, 18, 3696, 5441, 3]}, "items": [{"id": "p_3770", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3771", "content": "steroid [SEP] the capillary walls and mesangium. The patient was treated with steroid pulse, plasmapheresis, cyclophosphamide and antiplatelet agents", "tokenized_content": [2, 9507, 3, 1920, 9623, 12430, 1930, 23363, 2457, 18, 1920, 2774, 1982, 2868, 1956, 9507, 7110, 16, 3582, 15093, 1937, 16, 17135, 1930, 21348, 4820, 3]}, "items": [{"id": "p_3771", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3772", "content": "cyclophosphamide [SEP] um. The patient was treated with steroid pulse, plasmapheresis, cyclophosphamide and antiplatelet agents. A complete recovery of renal function ", "tokenized_content": [2, 17135, 3, 8736, 18, 1920, 2774, 1982, 2868, 1956, 9507, 7110, 16, 3582, 15093, 1937, 16, 17135, 1930, 21348, 4820, 18, 43, 4080, 5241, 1927, 4604, 2347, 3]}, "items": [{"id": "p_3772", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_3773", "content": "antiplatelet agents [SEP] reated with steroid pulse, plasmapheresis, cyclophosphamide and antiplatelet agents. A complete recovery of renal function was achieved in a few we", "tokenized_content": [2, 21348, 4820, 3, 1964, 1981, 1956, 9507, 7110, 16, 3582, 15093, 1937, 16, 17135, 1930, 21348, 4820, 18, 43, 4080, 5241, 1927, 4604, 2347, 1982, 5032, 1922, 43, 3855, 2038, 3]}, "items": [{"id": "p_3773", "content": "Platelet Aggregation Inhibitors [SEP] Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of act", "score": 1, "type": null, "tokenized_content": [2, 7163, 7883, 4472, 3, 4195, 2014, 4820, 2154, 28104, 2014, 3960, 2967, 2856, 4523, 1942, 2877, 7163, 7883, 16, 3053, 2409, 1920, 7643, 1927, 4033, 3]}]}
{"query": {"id": "q_3774", "content": "proteinuria [SEP] toring of renal function and evaluation of urinary sediment and proteinuria in these patients. The prompt discontinuation of D-penicillamin", "tokenized_content": [2, 15831, 3, 8184, 1941, 1927, 4604, 2347, 1930, 4391, 1927, 7075, 10363, 1930, 15831, 1922, 2144, 2132, 18, 1920, 14393, 14775, 1927, 46, 17, 25142, 3717, 3]}, "items": [{"id": "p_3774", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_3775", "content": "zidovudine [SEP] Nature, time course and dose dependence of zidovudine-related side effects: results from the Multicenter Canadian Azi", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 4899, 16, 2367, 4914, 1930, 3253, 6816, 1927, 28666, 22389, 1020, 20597, 17, 2712, 4159, 2564, 30, 2274, 2037, 1920, 14620, 13870, 6352, 1033, 3]}, "items": [{"id": "p_3775", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3776", "content": "Azidothymidine [SEP] ine-related side effects: results from the Multicenter Canadian Azidothymidine Trial.", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 11116, 17, 2712, 4159, 2564, 30, 2274, 2037, 1920, 14620, 13870, 6352, 15072, 28935, 16408, 2053, 3046, 18, 3]}, "items": [{"id": "p_3776", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3777", "content": "zidovudine [SEP] To characterize the nature, time course and dose dependency of zidovudine-related side effects, we undertook a multicenter, prospective, ", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 1942, 8063, 1920, 4899, 16, 2367, 4914, 1930, 3253, 14604, 1927, 28666, 22389, 1020, 20597, 17, 2712, 4159, 2564, 16, 2038, 23111, 43, 14620, 16, 3]}, "items": [{"id": "p_3777", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3778", "content": "HIV disease [SEP] C2 from the Centers for Disease Control (CDC) classification of HIV disease. Following a 3-week observation period, volunteers were treated", "tokenized_content": [2, 3525, 2573, 3, 8453, 2037, 1920, 7365, 1958, 2573, 2285, 12, 7137, 13, 5492, 1927, 3525, 2573, 18, 2894, 43, 23, 17, 2982, 5275, 3047, 16, 9701, 1985, 2868, 3]}, "items": [{"id": "p_3778", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_3779", "content": "nausea [SEP]  adverse effects were present in 96% of subjects, most commonly nausea (64%), fatigue (55%) and headache (49%). These were generally s", "tokenized_content": [2, 13759, 3, 5246, 2564, 1985, 2481, 1922, 4746, 9, 1927, 3297, 16, 2501, 5384, 13759, 12, 4723, 9, 13, 16, 8656, 12, 4288, 9, 13, 1930, 12187, 12, 4343, 9, 3]}, "items": [{"id": "p_3779", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_3780", "content": "fatigue [SEP] ts were present in 96% of subjects, most commonly nausea (64%), fatigue (55%) and headache (49%). These were generally self-limited, re", "tokenized_content": [2, 8656, 3, 4894, 1985, 2481, 1922, 4746, 9, 1927, 3297, 16, 2501, 5384, 13759, 12, 4723, 9, 13, 16, 8656, 12, 4288, 9, 13, 1930, 12187, 12, 4343, 9, 13, 3]}, "items": [{"id": "p_3780", "content": "Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re", "score": 1, "type": null, "tokenized_content": [2, 8656, 3, 1920, 3360, 1927, 12615, 8254, 2894, 43, 3047, 1927, 28187, 16, 5018, 2014, 3841, 16, 4378, 2007, 43, 3261, 4796, 1958, 2778, 1930, 1964, 3]}]}
{"query": {"id": "q_3781", "content": "headache [SEP]  96% of subjects, most commonly nausea (64%), fatigue (55%) and headache (49%). These were generally self-limited, reappearing briefly a", "tokenized_content": [2, 12187, 3, 4746, 9, 1927, 3297, 16, 2501, 5384, 13759, 12, 4723, 9, 13, 16, 8656, 12, 4288, 9, 13, 1930, 12187, 12, 4343, 9, 13, 18, 2144, 1985, 4933, 3]}, "items": [{"id": "p_3781", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_3782", "content": "Bilateral optic neuropathy [SEP] Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.", "tokenized_content": [2, 7787, 10109, 13177, 3, 7787, 10109, 13177, 2810, 1942, 4252, 3293, 6739, 1984, 1945, 1930, 28383, 2311, 18, 3]}, "items": [{"id": "p_3782", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_3783", "content": "ethambutol [SEP] Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 7787, 10109, 13177, 2810, 1942, 4252, 3293, 6739, 1984, 1945, 1930, 28383, 2311, 18, 3]}, "items": [{"id": "p_3783", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_3784", "content": "isoniazid [SEP] Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.", "tokenized_content": [2, 28383, 3, 7787, 10109, 13177, 2810, 1942, 4252, 3293, 6739, 1984, 1945, 1930, 28383, 2311, 18, 3]}, "items": [{"id": "p_3784", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_3785", "content": "ethambutol [SEP] nsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy w", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 4246, 18958, 2903, 20667, 5245, 6530, 1930, 1982, 2868, 1956, 3293, 6739, 1984, 1945, 1930, 28383, 1977, 2568, 18, 43, 7787, 7332, 17909, 1024, 8751, 3]}, "items": [{"id": "p_3785", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_3786", "content": "isoniazid [SEP] aver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual", "tokenized_content": [2, 28383, 3, 3142, 5245, 6530, 1930, 1982, 2868, 1956, 3293, 6739, 1984, 1945, 1930, 28383, 1977, 2568, 18, 43, 7787, 7332, 17909, 1024, 8751, 13177, 1956, 1925, 12236, 3]}, "items": [{"id": "p_3786", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_3787", "content": "bilateral retrobulbar neuropathy [SEP] on and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found", "tokenized_content": [2, 7787, 7332, 17909, 1024, 8751, 13177, 3, 1990, 1930, 1982, 2868, 1956, 3293, 6739, 1984, 1945, 1930, 28383, 1977, 2568, 18, 43, 7787, 7332, 17909, 1024, 8751, 13177, 1956, 1925, 3]}, "items": [{"id": "p_3787", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_3788", "content": "scotoma [SEP] bulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of", "tokenized_content": [2, 17162, 2954, 3, 17787, 1933, 13177, 1956, 1925, 12236, 4101, 21095, 6588, 6277, 28881, 9286, 19232, 17162, 2954, 1982, 2435, 18, 3293, 6739, 1984, 1945, 1982, 12032, 1930, 2444, 2858, 3]}, "items": [{"id": "p_3788", "content": "Scotoma [SEP] A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of EYE DISEASES (e.g., R", "score": 1, "type": null, "tokenized_content": [2, 17162, 2954, 3, 43, 6579, 7374, 1922, 1920, 3737, 3559, 9380, 1919, 2007, 1925, 3403, 1927, 2791, 9266, 18, 2052, 5110, 1956, 43, 5386, 1927, 5723, 3902, 12, 47, 18, 49, 18, 16, 60, 3]}]}
{"query": {"id": "q_3789", "content": "Ethambutol [SEP] ith an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity fol", "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 24737, 1925, 12236, 4101, 21095, 6588, 6277, 28881, 9286, 19232, 17162, 2954, 1982, 2435, 18, 3293, 6739, 1984, 1945, 1982, 12032, 1930, 2444, 2858, 4990, 3]}, "items": [{"id": "p_3789", "content": "Ethambutol [SEP] An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inh", "score": 1, "type": null, "tokenized_content": [2, 3293, 6739, 1984, 1945, 3, 1925, 10310, 29603, 2168, 5899, 1988, 7042, 1920, 3856, 1927, 5078, 4485, 4576, 2460, 1920, 2024, 4821, 1927, 1920, 7687, 1952, 14587, 18, 2176, 2278, 2222, 11035, 3]}]}
{"query": {"id": "q_3790", "content": "Isoniazid [SEP] opped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in t", "tokenized_content": [2, 28383, 3, 2494, 7438, 1930, 2444, 2858, 4990, 1927, 1920, 3737, 12320, 3489, 18, 28383, 1982, 16087, 3690, 16, 3489, 2007, 43, 10889, 4990, 1922, 62, 3]}, "items": [{"id": "p_3790", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_3791", "content": "toxicity [SEP] ic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger ", "tokenized_content": [2, 5532, 3, 3996, 4990, 1922, 1920, 3737, 12320, 18, 1920, 13456, 1927, 10109, 5507, 5532, 2810, 1942, 3293, 6739, 1984, 1945, 2032, 3171, 18, 2038, 14321, 1920, 2889, 15378, 3]}, "items": [{"id": "p_3791", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3792", "content": "blood coagulation [SEP] Progestational agents and blood coagulation. VII. Thromboembolic and other complications of oral contracept", "tokenized_content": [2, 2877, 12441, 3, 10759, 4926, 1923, 4820, 1930, 2877, 12441, 18, 16852, 18, 25580, 1930, 2303, 5021, 1927, 4726, 25266, 1031, 3]}, "items": [{"id": "p_3792", "content": "Blood Coagulation Disorders [SEP] Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of facto", "score": 1, "type": null, "tokenized_content": [2, 2877, 12441, 4414, 3, 16052, 1930, 21039, 4414, 1988, 4704, 1966, 43, 7749, 1927, 6754, 1922, 2877, 12441, 2810, 1942, 43, 5386, 1927, 2371, 1037, 3]}]}
{"query": {"id": "q_3793", "content": "Thromboembolic [SEP] Progestational agents and blood coagulation. VII. Thromboembolic and other complications of oral contraceptive therapy in relati", "tokenized_content": [2, 25580, 3, 10759, 4926, 1923, 4820, 1930, 2877, 12441, 18, 16852, 18, 25580, 1930, 2303, 5021, 1927, 4726, 16765, 3181, 1922, 22247, 1914, 3]}, "items": [{"id": "p_3793", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3794", "content": "oral contraceptive [SEP] ood coagulation. VII. Thromboembolic and other complications of oral contraceptive therapy in relationship to pretreatment levels of blood coagula", "tokenized_content": [2, 4726, 16765, 3, 57, 1986, 12441, 18, 16852, 18, 25580, 1930, 2303, 5021, 1927, 4726, 16765, 3181, 1922, 3303, 1942, 9111, 2428, 1927, 2877, 19804, 1019, 3]}, "items": [{"id": "p_3794", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_3795", "content": "oral contraceptives [SEP] total of 5,877 patient months in four separate studies relating oral contraceptives to changes in hematologic parameters. Significant increases in ", "tokenized_content": [2, 4726, 25434, 3, 2698, 1927, 25, 16, 5783, 1027, 2774, 3221, 1922, 3006, 5850, 2351, 13056, 4726, 25434, 1942, 2840, 1922, 18251, 3673, 18, 2228, 4041, 1922, 3]}, "items": [{"id": "p_3795", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_3796", "content": "blood coagulation [SEP] gic parameters. Significant increases in certain factors of the blood coagulation and fibrinolysin systems (factors I,II,VII,VIII,IX, and X and p", "tokenized_content": [2, 2877, 12441, 3, 7217, 1030, 3673, 18, 2228, 4041, 1922, 4908, 2790, 1927, 1920, 2877, 12441, 1930, 9450, 23872, 3771, 12, 2790, 51, 16, 2890, 16, 16852, 16, 18675, 16, 3]}, "items": [{"id": "p_3796", "content": "Blood Coagulation Disorders [SEP] Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of facto", "score": 1, "type": null, "tokenized_content": [2, 2877, 12441, 4414, 3, 16052, 1930, 21039, 4414, 1988, 4704, 1966, 43, 7749, 1927, 6754, 1922, 2877, 12441, 2810, 1942, 43, 5386, 1927, 2371, 1037, 3]}]}
{"query": {"id": "q_3797", "content": "hypercoagulability [SEP] All four had an abnormal blood coagulation profile, suggesting \"hypercoagulability\" before initiation of therapy. Some of these findings represent", "tokenized_content": [2, 14338, 6952, 11056, 11792, 2275, 3, 2136, 3006, 2430, 1925, 4552, 2877, 12441, 5174, 16, 3783, 6, 14338, 6952, 11056, 11792, 2275, 6, 3119, 6035, 1927, 3181, 18, 2673, 1927, 3]}, "items": [{"id": "p_3797", "content": "Thrombophilia [SEP] A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16379, 24888, 12191, 1019, 3, 43, 4770, 1927, 23963, 1922, 2154, 2276, 1977, 43, 10080, 1958, 1920, 6564, 1927, 11354, 18, 3]}]}
{"query": {"id": "q_3798", "content": "myocardial infarction [SEP] eased further during therapy. One of these patients developed a myocardial infarction before receiving any medication, shortly after the base-line va", "tokenized_content": [2, 6497, 8358, 3, 13832, 1007, 2520, 2409, 3181, 18, 2340, 1927, 2144, 2132, 3530, 43, 6497, 8358, 3119, 5962, 2967, 6093, 16, 17002, 2256, 1920, 5170, 17, 2823, 9315, 3]}, "items": [{"id": "p_3798", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3799", "content": "retinopathy [SEP] after the base-line values were obtained. One patient developed retinopathy 19 months after she began therapy, and another developed thromb", "tokenized_content": [2, 15508, 3, 2256, 1920, 5170, 17, 2823, 2851, 1985, 2926, 18, 2340, 2774, 3530, 15508, 2282, 3221, 2256, 4693, 10486, 3181, 16, 1930, 3741, 3530, 5700, 3]}, "items": [{"id": "p_3799", "content": "Retinal Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6943, 3902, 3, 3]}]}
{"query": {"id": "q_3800", "content": "thrombophlebitis [SEP] opathy 19 months after she began therapy, and another developed thrombophlebitis after 27 months of therapy. The fourth patient developed thromb", "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 20349, 28935, 2282, 3221, 2256, 4693, 10486, 3181, 16, 1930, 3741, 3530, 16379, 2102, 1952, 5443, 1937, 2256, 3225, 3221, 1927, 3181, 18, 1920, 3]}, "items": [{"id": "p_3800", "content": "Thrombophlebitis [SEP] Inflammation of a vein associated with a blood clot (THROMBUS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 4531, 1927, 43, 7920, 2458, 1956, 43, 2877, 15053, 12, 16705, 13, 18, 3]}]}
{"query": {"id": "q_3801", "content": "thromboembolic episodes [SEP]  studies suggested the possiblility of increased propensity for thromboembolic episodes in patients possessing the A antigen. It appears from these dat", "tokenized_content": [2, 25580, 9232, 3, 2351, 3978, 1920, 2776, 2023, 12191, 12191, 3145, 1927, 2502, 12020, 1958, 25580, 9232, 1922, 2132, 19705, 1920, 43, 4730, 18, 2176, 5107, 2037, 2144, 2181, 3]}, "items": [{"id": "p_3801", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3802", "content": "oral contraceptive [SEP] total of 5,877 patient months in four separate studies relating oral contraceptives to changes in hematologic parameters. Significant increases in", "tokenized_content": [2, 4726, 16765, 3, 2698, 1927, 25, 16, 5783, 1027, 2774, 3221, 1922, 3006, 5850, 2351, 13056, 4726, 25434, 1942, 2840, 1922, 18251, 3673, 18, 2228, 4041, 1922, 3]}, "items": [{"id": "p_3802", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_3803", "content": "Cardiac arrest [SEP] Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction", "tokenized_content": [2, 4435, 8048, 3, 4435, 8048, 1922, 43, 2748, 1956, 6329, 18698, 7258, 25564, 4408, 3]}, "items": [{"id": "p_3803", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_3804", "content": "cerebral palsy [SEP] Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperati", "tokenized_content": [2, 6329, 18698, 3, 4435, 8048, 1922, 43, 2748, 1956, 6329, 18698, 7258, 25564, 4408, 1927, 8871, 2256, 2097, 3556, 1968, 3]}, "items": [{"id": "p_3804", "content": "Cerebral Palsy [SEP] A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, ", "score": 1, "type": null, "tokenized_content": [2, 6329, 18698, 3, 43, 8538, 2210, 1927, 24857, 6405, 4479, 2320, 4842, 4414, 4189, 2007, 3724, 3068, 8209, 1988, 16786, 1922, 1920, 10907, 3047, 16, 3]}]}
{"query": {"id": "q_3805", "content": "sevoflurane [SEP] Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine.", "tokenized_content": [2, 25564, 3, 4435, 8048, 1922, 43, 2748, 1956, 6329, 18698, 7258, 25564, 4408, 1927, 8871, 2256, 8169, 26596, 18, 3]}, "items": [{"id": "p_3805", "content": "sevoflurane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25564, 3, 3]}]}
{"query": {"id": "q_3806", "content": "clonidine [SEP] dergoing sevoflurane induction of anesthesia after preoperative clonidine.", "tokenized_content": [2, 26596, 3, 3135, 8024, 25564, 4408, 1927, 8871, 2256, 8169, 26596, 18, 3]}, "items": [{"id": "p_3806", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_3807", "content": "Clonidine [SEP] Clonidine is a frequently administered alpha2-adrenergic agonist which ca", "tokenized_content": [2, 26596, 3, 26596, 1977, 43, 5467, 5254, 4595, 1028, 17, 13672, 7829, 2154, 2332, 3]}, "items": [{"id": "p_3807", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_3808", "content": "cerebral palsy [SEP] nd blood pressure. We present a case of a 5-year-old child with cerebral palsy and seizure disorder, receiving clonidine for restlessness, who", "tokenized_content": [2, 6329, 18698, 3, 8026, 2877, 3772, 18, 2038, 2481, 43, 3087, 1927, 43, 25, 17, 2476, 17, 4156, 2748, 1956, 6329, 18698, 1930, 11015, 4770, 16, 5962, 26596, 1958, 6172, 3]}, "items": [{"id": "p_3808", "content": "Cerebral Palsy [SEP] A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, ", "score": 1, "type": null, "tokenized_content": [2, 6329, 18698, 3, 43, 8538, 2210, 1927, 24857, 6405, 4479, 2320, 4842, 4414, 4189, 2007, 3724, 3068, 8209, 1988, 16786, 1922, 1920, 10907, 3047, 16, 3]}]}
{"query": {"id": "q_3809", "content": "seizure disorder [SEP] We present a case of a 5-year-old child with cerebral palsy and seizure disorder, receiving clonidine for restlessness, who presented for placem", "tokenized_content": [2, 11015, 4770, 3, 2038, 2481, 43, 3087, 1927, 43, 25, 17, 2476, 17, 4156, 2748, 1956, 6329, 18698, 1930, 11015, 4770, 16, 5962, 26596, 1958, 6172, 26481, 16, 2746, 3549, 3]}, "items": [{"id": "p_3809", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_3810", "content": "clonidine [SEP] r-old child with cerebral palsy and seizure disorder, receiving clonidine for restlessness, who presented for placement of a baclofen pum", "tokenized_content": [2, 26596, 3, 60, 17, 4156, 2748, 1956, 6329, 18698, 1930, 11015, 4770, 16, 5962, 26596, 1958, 6172, 26481, 16, 2746, 3549, 1958, 9555, 1927, 43, 30491, 18514, 13532, 3]}, "items": [{"id": "p_3810", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_3811", "content": "restlessness [SEP] th cerebral palsy and seizure disorder, receiving clonidine for restlessness, who presented for placement of a baclofen pump. Without the kn", "tokenized_content": [2, 6172, 26481, 3, 1913, 6329, 18698, 1930, 11015, 4770, 16, 5962, 26596, 1958, 6172, 26481, 16, 2746, 3549, 1958, 9555, 1927, 43, 30491, 18514, 8912, 18, 2979, 1920, 2547, 3]}, "items": [{"id": "p_3811", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_3812", "content": "baclofen [SEP] ng clonidine for restlessness, who presented for placement of a baclofen pump. Without the knowledge of the medical personnel, the patie", "tokenized_content": [2, 30491, 18514, 3, 4375, 26596, 1958, 6172, 26481, 16, 2746, 3549, 1958, 9555, 1927, 43, 30491, 18514, 8912, 18, 2979, 1920, 4163, 1927, 1920, 3423, 12811, 16, 1920, 2091, 1021, 3]}, "items": [{"id": "p_3812", "content": "Baclofen [SEP] A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPAST", "score": 1, "type": null, "tokenized_content": [2, 30491, 18514, 3, 43, 7034, 17, 29093, 2687, 10533, 1988, 1977, 43, 2487, 7829, 1927, 7992, 17, 44, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3760, 19361, 2156, 3]}]}
{"query": {"id": "q_3813", "content": "anxiety [SEP] dine during the evening before and morning of surgery to reduce anxiety. During induction of anesthesia, the patient developed bradycar", "tokenized_content": [2, 5592, 3, 11687, 1021, 2409, 1920, 19162, 3119, 1930, 12661, 1927, 3782, 1942, 4412, 5592, 18, 2409, 4408, 1927, 8871, 16, 1920, 2774, 3530, 20152, 15339, 3]}, "items": [{"id": "p_3813", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_3814", "content": "bradycardia [SEP]  anxiety. During induction of anesthesia, the patient developed bradycardia and hypotension requiring cardiac resuscitation. There are no p", "tokenized_content": [2, 26192, 3, 5592, 18, 2409, 4408, 1927, 8871, 16, 1920, 2774, 3530, 26192, 1930, 16453, 8887, 4435, 15371, 18, 2276, 2032, 2239, 58, 3]}, "items": [{"id": "p_3814", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_3815", "content": "hypotension [SEP]  induction of anesthesia, the patient developed bradycardia and hypotension requiring cardiac resuscitation. There are no previous reports ", "tokenized_content": [2, 16453, 3, 4408, 1927, 8871, 16, 1920, 2774, 3530, 26192, 1930, 16453, 8887, 4435, 15371, 18, 2276, 2032, 2239, 2555, 4710, 3]}, "items": [{"id": "p_3815", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3816", "content": "cardiac arrest [SEP] citation. There are no previous reports of clonidine-associated cardiac arrest in a child undergoing induction of anesthesia.", "tokenized_content": [2, 4435, 8048, 3, 21083, 18, 2276, 2032, 2239, 2555, 4710, 1927, 26596, 17, 2458, 4435, 8048, 1922, 43, 2748, 7258, 4408, 1927, 8871, 18, 3]}, "items": [{"id": "p_3816", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_3817", "content": "UMB24 [SEP] Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on beh", "tokenized_content": [2, 25589, 4561, 3, 2564, 1927, 25589, 4561, 1930, 12, 15, 19, 17, 13, 17, 2426, 2900, 16, 6770, 5139, 1028, 17, 4458, 8641, 10515, 16, 1990, 9033, 3]}, "items": [{"id": "p_3817", "content": "1-(2-phenethyl)-4-(2-pyridyl)piperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 24, 17, 12, 22, 17, 24828, 2199, 13, 16057, 10119, 3, 3]}]}
{"query": {"id": "q_3818", "content": "SM 21 [SEP] Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic an", "tokenized_content": [2, 2426, 2900, 3, 2564, 1927, 25589, 4561, 1930, 12, 15, 19, 17, 13, 17, 2426, 2900, 16, 6770, 5139, 1028, 17, 4458, 8641, 10515, 16, 1990, 5343, 6161, 1925, 3]}, "items": [{"id": "p_3818", "content": "SM 21 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2426, 2900, 3, 3]}]}
{"query": {"id": "q_3819", "content": "cocaine [SEP] rring antagonists, on behavioral toxic and stimulant effects of cocaine in mice.", "tokenized_content": [2, 9045, 3, 5162, 1941, 10515, 16, 1990, 5343, 6161, 1930, 24252, 2564, 1927, 9045, 1922, 2518, 18, 3]}, "items": [{"id": "p_3819", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3820", "content": "convulsive [SEP] demonstrated that antagonism of sigma1 receptors attenuates the convulsive, lethal, locomotor stimulatory and rewarding actions of cocaine", "tokenized_content": [2, 4772, 13042, 3, 3161, 1988, 18394, 1927, 5139, 1009, 4086, 18260, 1920, 4772, 13042, 16, 10470, 16, 13594, 14971, 1930, 25894, 7728, 1927, 9045, 3]}, "items": [{"id": "p_3820", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3821", "content": "cocaine [SEP] vulsive, lethal, locomotor stimulatory and rewarding actions of cocaine in mice. In contrast, the contribution of sigma2 receptors is u", "tokenized_content": [2, 9045, 3, 7343, 12924, 1961, 16, 10470, 16, 13594, 14971, 1930, 25894, 7728, 1927, 9045, 1922, 2518, 18, 1922, 3320, 16, 1920, 5100, 1927, 5139, 1028, 4086, 1977, 63, 3]}, "items": [{"id": "p_3821", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3822", "content": "UMB24 [SEP] re unavailable. To begin addressing this need, we characterized UMB24 (1-(2-phenethyl)-4-(2-pyridyl)-piperazine) and (+/-)-SM 21 (3al", "tokenized_content": [2, 25589, 4561, 3, 1964, 21027, 18, 1942, 11763, 12160, 2052, 2942, 16, 2038, 4378, 25589, 4561, 12, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 24, 17, 12, 22, 3]}, "items": [{"id": "p_3822", "content": "1-(2-phenethyl)-4-(2-pyridyl)piperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 24, 17, 12, 22, 17, 24828, 2199, 13, 16057, 10119, 3, 3]}]}
{"query": {"id": "q_3823", "content": "1-(2-phenethyl)-4-(2-pyridyl)-piperazine [SEP] ailable. To begin addressing this need, we characterized UMB24 (1-(2-phenethyl)-4-(2-pyridyl)-piperazine) and (+/-)-SM 21 (3alpha-tropanyl-2-(4-chorophenoxy)butyrate) i", "tokenized_content": [2, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 24, 17, 12, 22, 17, 24828, 2199, 13, 17, 16057, 10119, 3, 30500, 2115, 18, 1942, 11763, 12160, 2052, 2942, 16, 3]}, "items": [{"id": "p_3823", "content": "1-(2-phenethyl)-4-(2-pyridyl)piperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 24, 17, 12, 22, 17, 24828, 2199, 13, 16057, 10119, 3, 3]}]}
{"query": {"id": "q_3824", "content": "SM 21 [SEP] ized UMB24 (1-(2-phenethyl)-4-(2-pyridyl)-piperazine) and (+/-)-SM 21 (3alpha-tropanyl-2-(4-chorophenoxy)butyrate) in receptor bindin", "tokenized_content": [2, 2426, 2900, 3, 25455, 1919, 25589, 4561, 12, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 24, 17, 12, 22, 17, 24828, 2199, 13, 17, 16057, 10119, 13, 1930, 3]}, "items": [{"id": "p_3824", "content": "SM 21 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2426, 2900, 3, 3]}]}
{"query": {"id": "q_3825", "content": "3alpha-tropanyl-2-(4-chorophenoxy)butyrate [SEP] B24 (1-(2-phenethyl)-4-(2-pyridyl)-piperazine) and (+/-)-SM 21 (3alpha-tropanyl-2-(4-chorophenoxy)butyrate) in receptor binding and behavioral studies. Receptor binding s", "tokenized_content": [2, 5694, 13857, 2722, 17, 8465, 12804, 17, 22, 17, 12, 24, 17, 11418, 12218, 7221, 13, 19793, 3, 11054, 1006, 12, 21, 17, 12, 22, 17, 3037, 5188, 13, 17, 3]}, "items": [{"id": "p_3825", "content": "SM 21 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2426, 2900, 3, 3]}]}
{"query": {"id": "q_3826", "content": "convulsions [SEP] h UMB24 or (+/-)-SM 21 significantly attenuated cocaine-induced convulsions and locomotor activity, but not lethality. When administered al", "tokenized_content": [2, 4772, 19389, 3, 50, 25589, 4561, 2014, 12, 15, 19, 17, 13, 17, 2426, 2900, 2567, 8060, 9045, 17, 2719, 4772, 19389, 1930, 13594, 2455, 16, 2308, 2084, 15400, 18, 3]}, "items": [{"id": "p_3826", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3827", "content": "Methimazole [SEP] Methimazole-induced cholestatic jaundice.", "tokenized_content": [2, 2295, 12874, 13642, 1952, 3, 2295, 12874, 13642, 1952, 17, 2719, 21211, 2479, 25314, 18, 3]}, "items": [{"id": "p_3827", "content": "Methimazole [SEP] A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine", "score": 1, "type": null, "tokenized_content": [2, 2295, 12874, 13642, 1952, 3, 43, 15331, 2027, 6752, 2912, 10310, 30338, 12245, 5899, 1988, 7042, 1920, 3337, 1927, 6918, 10224, 2007, 13369, 1956, 1920, 8629, 1927, 14836, 3]}]}
{"query": {"id": "q_3828", "content": "cholestatic jaundice [SEP] Methimazole-induced cholestatic jaundice.", "tokenized_content": [2, 21211, 2479, 25314, 3, 2295, 12874, 13642, 1952, 17, 2719, 21211, 2479, 25314, 18, 3]}, "items": [{"id": "p_3828", "content": "Jaundice, Obstructive [SEP] Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIA", "score": 1, "type": null, "tokenized_content": [2, 25314, 16, 12234, 3, 25314, 16, 1920, 2625, 1956, 7463, 2471, 4166, 1927, 1920, 4407, 1930, 27103, 5726, 16, 1988, 1977, 2810, 1942, 5761, 9619, 3426, 1922, 1920, 5088, 2126, 3]}]}
{"query": {"id": "q_3829", "content": "Methimazole [SEP] Methimazole is a widely used and generally well-tolerated antithyroid agent", "tokenized_content": [2, 2295, 12874, 13642, 1952, 3, 2295, 12874, 13642, 1952, 1977, 43, 5673, 2251, 1930, 4933, 2486, 17, 11117, 10310, 30338, 12245, 5899, 3]}, "items": [{"id": "p_3829", "content": "Methimazole [SEP] A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine", "score": 1, "type": null, "tokenized_content": [2, 2295, 12874, 13642, 1952, 3, 43, 15331, 2027, 6752, 2912, 10310, 30338, 12245, 5899, 1988, 7042, 1920, 3337, 1927, 6918, 10224, 2007, 13369, 1956, 1920, 8629, 1927, 14836, 3]}]}
{"query": {"id": "q_3830", "content": "jaundice [SEP] ell-tolerated antithyroid agent. A 43-year-old woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) and", "tokenized_content": [2, 25314, 3, 20430, 17, 11117, 10310, 30338, 12245, 5899, 18, 43, 3941, 17, 2476, 17, 4156, 10440, 2430, 4010, 25314, 1930, 20687, 1941, 21, 2935, 2256, 5962, 2295, 12874, 13642, 3]}, "items": [{"id": "p_3830", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_3831", "content": "itching [SEP]  antithyroid agent. A 43-year-old woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) and propranolol", "tokenized_content": [2, 20687, 1941, 3, 10310, 30338, 12245, 5899, 18, 43, 3941, 17, 2476, 17, 4156, 10440, 2430, 4010, 25314, 1930, 20687, 1941, 21, 2935, 2256, 5962, 2295, 12874, 13642, 1952, 12, 3]}, "items": [{"id": "p_3831", "content": "Pruritus [SEP] An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27496, 3, 1925, 10702, 20687, 1941, 15826, 1988, 9300, 1920, 11460, 1021, 1942, 10010, 2014, 18480, 1920, 4407, 1942, 5649, 13104, 18, 3]}]}
{"query": {"id": "q_3832", "content": "methimazole [SEP] d woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) and propranolol (20 mg tid) for treatment of hypert", "tokenized_content": [2, 2295, 12874, 13642, 1952, 3, 46, 10440, 2430, 4010, 25314, 1930, 20687, 1941, 21, 2935, 2256, 5962, 2295, 12874, 13642, 1952, 12, 2119, 2786, 8685, 1007, 13, 1930, 21395, 12, 3]}, "items": [{"id": "p_3832", "content": "Methimazole [SEP] A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine", "score": 1, "type": null, "tokenized_content": [2, 2295, 12874, 13642, 1952, 3, 43, 15331, 2027, 6752, 2912, 10310, 30338, 12245, 5899, 1988, 7042, 1920, 3337, 1927, 6918, 10224, 2007, 13369, 1956, 1920, 8629, 1927, 14836, 3]}]}
{"query": {"id": "q_3833", "content": "propranolol [SEP] and itching 1 month after receiving methimazole (10 mg tid) and propranolol (20 mg tid) for treatment of hyperthyroidism. The patient conti", "tokenized_content": [2, 21395, 3, 1930, 20687, 1941, 21, 2935, 2256, 5962, 2295, 12874, 13642, 1952, 12, 2119, 2786, 8685, 1007, 13, 1930, 21395, 12, 2036, 2786, 8685, 1007, 13, 1958, 2311, 1927, 3]}, "items": [{"id": "p_3833", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_3834", "content": "hyperthyroidism [SEP] mazole (10 mg tid) and propranolol (20 mg tid) for treatment of hyperthyroidism. The patient continued treatment for another 4 days after the a", "tokenized_content": [2, 28413, 3, 26701, 2456, 12, 2119, 2786, 8685, 1007, 13, 1930, 21395, 12, 2036, 2786, 8685, 1007, 13, 1958, 2311, 1927, 28413, 18, 1920, 2774, 7583, 2311, 1958, 3741, 24, 3]}, "items": [{"id": "p_3834", "content": "Hyperthyroidism [SEP] Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28413, 3, 10694, 1940, 10411, 2001, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 18, 4664, 2428, 1927, 6918, 10224, 2760, 5342, 4487, 2769, 18, 3]}]}
{"query": {"id": "q_3835", "content": "icterus [SEP] at the emergency department 2 weeks later, she still had severe icterus, pruritus, and hyperbilirubinemia, formed mainly of the conjuga", "tokenized_content": [2, 18451, 25822, 3, 2019, 1920, 7877, 6143, 22, 3625, 3690, 16, 4693, 3974, 2430, 4010, 18451, 25822, 16, 27496, 16, 1930, 4194, 12039, 14560, 3847, 16, 5333, 4994, 1927, 1920, 3]}, "items": [{"id": "p_3835", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_3836", "content": "pruritus [SEP] ergency department 2 weeks later, she still had severe icterus, pruritus, and hyperbilirubinemia, formed mainly of the conjugated fracti", "tokenized_content": [2, 27496, 3, 11949, 2589, 6143, 22, 3625, 3690, 16, 4693, 3974, 2430, 4010, 18451, 25822, 16, 27496, 16, 1930, 4194, 12039, 14560, 3847, 16, 5333, 4994, 1927, 1920, 6765, 5615, 3]}, "items": [{"id": "p_3836", "content": "Pruritus [SEP] An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27496, 3, 1925, 10702, 20687, 1941, 15826, 1988, 9300, 1920, 11460, 1021, 1942, 10010, 2014, 18480, 1920, 4407, 1942, 5649, 13104, 18, 3]}]}
{"query": {"id": "q_3837", "content": "hyperbilirubinemia [SEP] ment 2 weeks later, she still had severe icterus, pruritus, and hyperbilirubinemia, formed mainly of the conjugated fraction. Methimazole-induced ", "tokenized_content": [2, 4194, 12039, 14560, 3847, 3, 11567, 22, 3625, 3690, 16, 4693, 3974, 2430, 4010, 18451, 25822, 16, 27496, 16, 1930, 4194, 12039, 14560, 3847, 16, 5333, 4994, 1927, 1920, 6765, 3]}, "items": [{"id": "p_3837", "content": "Hyperbilirubinemia [SEP] A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdow", "score": 1, "type": null, "tokenized_content": [2, 4194, 12039, 14560, 3847, 3, 43, 2625, 4378, 2007, 1925, 4552, 2760, 1927, 15702, 1922, 1920, 2877, 16, 2154, 2278, 3211, 1922, 25314, 18, 15702, 16, 43, 6017, 22389, 1018, 3]}]}
{"query": {"id": "q_3838", "content": "cholestasis [SEP] , formed mainly of the conjugated fraction. Methimazole-induced cholestasis was diagnosed, and propranolol therapy was resumed. Over the fo", "tokenized_content": [2, 30086, 3, 16, 5333, 4994, 1927, 1920, 6765, 3906, 18, 2295, 12874, 13642, 1952, 17, 2719, 30086, 1982, 5377, 16, 1930, 21395, 3181, 1982, 22380, 1919, 18, 2338, 1920, 5917, 3]}, "items": [{"id": "p_3838", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3839", "content": "bilirubin [SEP] 2 weeks later, she still had severe icterus, pruritus, and hyperbilirubinemia, formed mainly of the conjugated fraction. Methimazole-indu", "tokenized_content": [2, 15702, 3, 22, 3625, 3690, 16, 4693, 3974, 2430, 4010, 18451, 25822, 16, 27496, 16, 1930, 4194, 12039, 14560, 3847, 16, 5333, 4994, 1927, 1920, 6765, 3906, 18, 2295, 12874, 3]}, "items": [{"id": "p_3839", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_3840", "content": "cholestatic jaundice [SEP] few weeks of therapy, this drug can cause severe and reversible cholestatic jaundice. Physicians and patients should be aware of this adverse effect", "tokenized_content": [2, 21211, 2479, 25314, 3, 3855, 3625, 1927, 3181, 16, 2052, 2838, 2112, 3936, 4010, 1930, 10743, 21211, 2479, 25314, 18, 6967, 1930, 2132, 3066, 1998, 11207, 1927, 2052, 5246, 2495, 3]}, "items": [{"id": "p_3840", "content": "Jaundice, Obstructive [SEP] Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIA", "score": 1, "type": null, "tokenized_content": [2, 25314, 16, 12234, 3, 25314, 16, 1920, 2625, 1956, 7463, 2471, 4166, 1927, 1920, 4407, 1930, 27103, 5726, 16, 1988, 1977, 2810, 1942, 5761, 9619, 3426, 1922, 1920, 5088, 2126, 3]}]}
{"query": {"id": "q_3841", "content": "Ciprofloxacin [SEP] Ciprofloxacin-induced acute interstitial nephritis and autoimmune hemolytic a", "tokenized_content": [2, 18502, 3, 18502, 17, 2719, 3939, 11584, 25064, 1930, 8904, 21515, 43, 3]}, "items": [{"id": "p_3841", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_3842", "content": "interstitial nephritis [SEP] Ciprofloxacin-induced acute interstitial nephritis and autoimmune hemolytic anemia.", "tokenized_content": [2, 11584, 25064, 3, 18502, 17, 2719, 3939, 11584, 25064, 1930, 8904, 21515, 10679, 18, 3]}, "items": [{"id": "p_3842", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_3843", "content": "autoimmune hemolytic anemia [SEP] Ciprofloxacin-induced acute interstitial nephritis and autoimmune hemolytic anemia.", "tokenized_content": [2, 8904, 21515, 10679, 3, 18502, 17, 2719, 3939, 11584, 25064, 1930, 8904, 21515, 10679, 18, 3]}, "items": [{"id": "p_3843", "content": "Anemia, Hemolytic, Autoimmune [SEP] Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.\n   ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 16, 8904, 3, 5815, 21515, 10679, 2810, 1942, 1920, 2990, 1927, 15510, 2154, 20262, 2010, 2014, 3629, 1021, 1920, 2774, 11, 61, 6614, 2312, 2877, 2094, 18, 3]}]}
{"query": {"id": "q_3844", "content": "Ciprofloxacin [SEP] Ciprofloxacin has been associated with several side effects including interst", "tokenized_content": [2, 18502, 3, 18502, 2258, 2252, 2458, 1956, 2980, 4159, 2564, 2710, 7934, 1031, 3]}, "items": [{"id": "p_3844", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_3845", "content": "interstitial nephritis [SEP] loxacin has been associated with several side effects including interstitial nephritis and hemolytic anemia. The combination of both side effects is e", "tokenized_content": [2, 11584, 25064, 3, 11846, 9151, 2258, 2252, 2458, 1956, 2980, 4159, 2564, 2710, 11584, 25064, 1930, 21515, 10679, 18, 1920, 3921, 1927, 2321, 4159, 2564, 1977, 47, 3]}, "items": [{"id": "p_3845", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_3846", "content": "hemolytic anemia [SEP]  with several side effects including interstitial nephritis and hemolytic anemia. The combination of both side effects is extremely rare. In thi", "tokenized_content": [2, 21515, 10679, 3, 1956, 2980, 4159, 2564, 2710, 11584, 25064, 1930, 21515, 10679, 18, 1920, 3921, 1927, 2321, 4159, 2564, 1977, 8113, 5844, 18, 1922, 7566, 3]}, "items": [{"id": "p_3846", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3847", "content": "ciprofloxacin [SEP] ffects is extremely rare. In this report, we describe a case of ciprofloxacin-induced interstitial nephritis and autoimmune hemolytic anemia.", "tokenized_content": [2, 18502, 3, 10735, 2284, 1977, 8113, 5844, 18, 1922, 2052, 3809, 16, 2038, 5993, 43, 3087, 1927, 18502, 17, 2719, 11584, 25064, 1930, 8904, 21515, 10679, 18, 3]}, "items": [{"id": "p_3847", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_3848", "content": "autoimmune hemolytic anemia [SEP] ribe a case of ciprofloxacin-induced interstitial nephritis and autoimmune hemolytic anemia. Hemolytic anemia improved after stopping the drug and initiati", "tokenized_content": [2, 8904, 21515, 10679, 3, 5216, 1021, 43, 3087, 1927, 18502, 17, 2719, 11584, 25064, 1930, 8904, 21515, 10679, 18, 21515, 10679, 4305, 2256, 20225, 1920, 2838, 1930, 2907, 1968, 3]}, "items": [{"id": "p_3848", "content": "Anemia, Hemolytic, Autoimmune [SEP] Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.\n   ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 16, 8904, 3, 5815, 21515, 10679, 2810, 1942, 1920, 2990, 1927, 15510, 2154, 20262, 2010, 2014, 3629, 1021, 1920, 2774, 11, 61, 6614, 2312, 2877, 2094, 18, 3]}]}
{"query": {"id": "q_3849", "content": "Hemolytic anemia [SEP] induced interstitial nephritis and autoimmune hemolytic anemia. Hemolytic anemia improved after stopping the drug and initiation of steroid ther", "tokenized_content": [2, 21515, 10679, 3, 2719, 11584, 25064, 1930, 8904, 21515, 10679, 18, 21515, 10679, 4305, 2256, 20225, 1920, 2838, 1930, 6035, 1927, 9507, 2704, 3]}, "items": [{"id": "p_3849", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3850", "content": "steroid [SEP] lytic anemia improved after stopping the drug and initiation of steroid therapy. Unfortunately, acute interstitial nephritis was irreve", "tokenized_content": [2, 9507, 3, 17033, 10679, 4305, 2256, 20225, 1920, 2838, 1930, 6035, 1927, 9507, 3181, 18, 10714, 16, 3939, 11584, 25064, 1982, 10137, 1961, 3]}, "items": [{"id": "p_3850", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_3851", "content": "end-stage renal disease [SEP] terstitial nephritis was irreversible and the patient developed end-stage renal disease.", "tokenized_content": [2, 2482, 17, 3587, 4604, 2573, 3, 6005, 2156, 2078, 1923, 25064, 1982, 14104, 1930, 1920, 2774, 3530, 2482, 17, 3587, 4604, 2573, 18, 3]}, "items": [{"id": "p_3851", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_3852", "content": "sodium valproate [SEP] Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic horm", "tokenized_content": [2, 5227, 23867, 2010, 3, 5100, 1927, 5227, 23867, 2010, 1942, 1920, 4741, 1927, 13770, 5512, 1927, 22576, 15766, 5037, 3]}, "items": [{"id": "p_3852", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3853", "content": "syndrome of inappropriate secretion of antidiuretic hormone [SEP] Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone.", "tokenized_content": [2, 4741, 1927, 13770, 5512, 1927, 22576, 15766, 6365, 3, 5100, 1927, 5227, 23867, 2010, 1942, 1920, 4741, 1927, 13770, 5512, 1927, 22576, 15766, 6365, 18, 3]}, "items": [{"id": "p_3853", "content": "Inappropriate ADH Syndrome [SEP] A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of A", "score": 1, "type": null, "tokenized_content": [2, 13770, 21918, 4741, 3, 43, 2625, 1927, 29758, 6026, 1930, 4604, 7012, 3257, 6898, 1942, 4592, 6528, 12924, 1916, 1927, 3362, 13315, 3864, 2037, 7637, 4012, 1927, 43, 3]}]}
{"query": {"id": "q_3854", "content": "sodium valproate [SEP] We report the case of a 62-year-old man who was administered sodium valproate (VPA) and who subsequently developed the syndrome of inappropri", "tokenized_content": [2, 5227, 23867, 2010, 3, 2038, 3809, 1920, 3087, 1927, 43, 5374, 17, 2476, 17, 4156, 2323, 2746, 1982, 5254, 5227, 23867, 2010, 12, 19703, 13, 1930, 2746, 5326, 3530, 1920, 3]}, "items": [{"id": "p_3854", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3855", "content": "VPA [SEP] ase of a 62-year-old man who was administered sodium valproate (VPA) and who subsequently developed the syndrome of inappropriate s", "tokenized_content": [2, 19703, 3, 28826, 1927, 43, 5374, 17, 2476, 17, 4156, 2323, 2746, 1982, 5254, 5227, 23867, 2010, 12, 19703, 13, 1930, 2746, 5326, 3530, 1920, 4741, 1927, 13770, 61, 3]}, "items": [{"id": "p_3855", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3856", "content": "syndrome of inappropriate secretion of antidiuretic hormone [SEP] tered sodium valproate (VPA) and who subsequently developed the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). He had been taking VPA for treatment of idiopathic gen", "tokenized_content": [2, 4741, 1927, 13770, 5512, 1927, 22576, 15766, 6365, 3, 6005, 1919, 5227, 23867, 2010, 12, 19703, 13, 1930, 2746, 5326, 3530, 1920, 4741, 1927, 13770, 5512, 1927, 22576, 15766, 6365, 3]}, "items": [{"id": "p_3856", "content": "Inappropriate ADH Syndrome [SEP] A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of A", "score": 1, "type": null, "tokenized_content": [2, 13770, 21918, 4741, 3, 43, 2625, 1927, 29758, 6026, 1930, 4604, 7012, 3257, 6898, 1942, 4592, 6528, 12924, 1916, 1927, 3362, 13315, 3864, 2037, 7637, 4012, 1927, 43, 3]}]}
{"query": {"id": "q_3857", "content": "SIADH [SEP] he syndrome of inappropriate secretion of antidiuretic hormone (SIADH). He had been taking VPA for treatment of idiopathic generalize", "tokenized_content": [2, 26352, 6018, 3, 2234, 4741, 1927, 13770, 5512, 1927, 22576, 15766, 6365, 12, 26352, 6018, 13, 18, 2234, 2430, 2252, 6303, 19703, 1958, 2311, 1927, 13513, 24012, 3]}, "items": [{"id": "p_3857", "content": "Inappropriate ADH Syndrome [SEP] A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of A", "score": 1, "type": null, "tokenized_content": [2, 13770, 21918, 4741, 3, 43, 2625, 1927, 29758, 6026, 1930, 4604, 7012, 3257, 6898, 1942, 4592, 6528, 12924, 1916, 1927, 3362, 13315, 3864, 2037, 7637, 4012, 1927, 43, 3]}]}
{"query": {"id": "q_3858", "content": "tonic-clonic convulsions [SEP]  He had been taking VPA for treatment of idiopathic generalized tonic-clonic convulsions since he was 56 years old. After substituting VPA with zonisami", "tokenized_content": [2, 16887, 17, 6138, 1935, 4772, 19389, 3, 2234, 2430, 2252, 6303, 19703, 1958, 2311, 1927, 13513, 9612, 16887, 17, 6138, 1935, 4772, 19389, 3328, 2234, 1982, 4489, 2739, 4156, 18, 3]}, "items": [{"id": "p_3858", "content": "Epilepsy, Tonic-Clonic [SEP] A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 16887, 17, 6138, 1935, 3, 43, 9612, 11015, 4770, 4378, 2007, 7457, 3044, 4842, 10060, 18, 1920, 3754, 5310, 16887, 3193, 1977, 4961, 2007, 13717, 3]}]}
{"query": {"id": "q_3859", "content": "zonisamide [SEP] vulsions since he was 56 years old. After substituting VPA with zonisamide, the serum sodium level returned to normal. We consider this ep", "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 7343, 12924, 2101, 3328, 2234, 1982, 4489, 2739, 4156, 18, 2256, 26276, 19703, 1956, 26533, 6509, 16408, 1021, 16, 1920, 3256, 5227, 2237, 10418, 1942, 3]}, "items": [{"id": "p_3859", "content": "zonisamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 3]}]}
{"query": {"id": "q_3860", "content": "sodium [SEP] We report the case of a 62-year-old man who was administered sodium valproate (VPA) and who subsequently developed the syndrome of ", "tokenized_content": [2, 5227, 3, 2038, 3809, 1920, 3087, 1927, 43, 5374, 17, 2476, 17, 4156, 2323, 2746, 1982, 5254, 5227, 23867, 2010, 12, 19703, 13, 1930, 2746, 5326, 3530, 1920, 4741, 1927, 3]}, "items": [{"id": "p_3860", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3861", "content": "weakness of the central nervous system [SEP]  SIADH to be the result of a combination of factors including a weakness of the central nervous system and the long-term administration of VPA.", "tokenized_content": [2, 12175, 1927, 1920, 4101, 7580, 2433, 3, 26352, 6018, 1942, 1998, 1920, 3211, 1927, 43, 3921, 1927, 2790, 2710, 43, 12175, 1927, 1920, 4101, 7580, 2433, 1930, 1920, 2815, 17, 3]}, "items": [{"id": "p_3861", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_3862", "content": "Vasopressin [SEP] Vasopressin in the treatment of milrinone-induced hypotension in severe hea", "tokenized_content": [2, 20671, 3, 20671, 1922, 1920, 2311, 1927, 5142, 5572, 2290, 17, 2719, 16453, 1922, 4010, 2234, 1019, 3]}, "items": [{"id": "p_3862", "content": "Vasopressins [SEP] Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balan", "score": 1, "type": null, "tokenized_content": [2, 20671, 1036, 3, 22576, 15766, 10224, 6988, 2007, 1920, 3366, 30338, 7056, 25818, 8362, 1927, 2136, 14976, 12, 3170, 10229, 1956, 3038, 13, 1942, 5741, 3224, 4641, 1928, 3]}]}
{"query": {"id": "q_3863", "content": "milrinone [SEP] Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure.", "tokenized_content": [2, 5142, 5572, 2290, 3, 20671, 1922, 1920, 2311, 1927, 5142, 5572, 2290, 17, 2719, 16453, 1922, 4010, 4003, 4574, 18, 3]}, "items": [{"id": "p_3863", "content": "Milrinone [SEP] A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocar", "score": 1, "type": null, "tokenized_content": [2, 5142, 5572, 2290, 3, 43, 2843, 28853, 21129, 24970, 5899, 1956, 28194, 3879, 18, 2176, 7042, 6225, 24821, 2601, 23, 2455, 1922, 15924, 15339, 3]}]}
{"query": {"id": "q_3864", "content": "hypotension [SEP] Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure.", "tokenized_content": [2, 16453, 3, 20671, 1922, 1920, 2311, 1927, 5142, 5572, 2290, 17, 2719, 16453, 1922, 4010, 4003, 4574, 18, 3]}, "items": [{"id": "p_3864", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3865", "content": "heart failure [SEP] sin in the treatment of milrinone-induced hypotension in severe heart failure.", "tokenized_content": [2, 4003, 4574, 3, 3132, 1922, 1920, 2311, 1927, 5142, 5572, 2290, 17, 2719, 16453, 1922, 4010, 4003, 4574, 18, 3]}, "items": [{"id": "p_3865", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3866", "content": "milrinone [SEP] The use of phosphodiesterase inhibitors such as milrinone in the treatment of severe heart failure is frequently restrict", "tokenized_content": [2, 5142, 5572, 2290, 3, 1920, 2485, 1927, 24821, 4472, 2427, 1966, 5142, 5572, 2290, 1922, 1920, 2311, 1927, 4010, 4003, 4574, 1977, 5467, 18240, 3]}, "items": [{"id": "p_3866", "content": "Milrinone [SEP] A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocar", "score": 1, "type": null, "tokenized_content": [2, 5142, 5572, 2290, 3, 43, 2843, 28853, 21129, 24970, 5899, 1956, 28194, 3879, 18, 2176, 7042, 6225, 24821, 2601, 23, 2455, 1922, 15924, 15339, 3]}]}
{"query": {"id": "q_3867", "content": "heart failure [SEP] sterase inhibitors such as milrinone in the treatment of severe heart failure is frequently restricted because they cause vasodilation and hy", "tokenized_content": [2, 4003, 4574, 3, 4987, 2051, 4472, 2427, 1966, 5142, 5572, 2290, 1922, 1920, 2311, 1927, 4010, 4003, 4574, 1977, 5467, 6715, 2882, 2611, 3936, 21742, 1930, 4527, 3]}, "items": [{"id": "p_3867", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3868", "content": "hypotension [SEP] re is frequently restricted because they cause vasodilation and hypotension. In patients with decompensated heart failure with hypotension ", "tokenized_content": [2, 16453, 3, 1964, 1977, 5467, 6715, 2882, 2611, 3936, 21742, 1930, 16453, 18, 1922, 2132, 1956, 24691, 1981, 4003, 4574, 1956, 16453, 3]}, "items": [{"id": "p_3868", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3869", "content": "vasopressin [SEP] e with hypotension after treatment with milrinone, low doses of vasopressin restored blood pressure without inhibiting the inotropic effect", "tokenized_content": [2, 20671, 3, 47, 1956, 16453, 2256, 2311, 1956, 5142, 5572, 2290, 16, 2330, 5312, 1927, 20671, 10680, 2877, 3772, 2979, 7918, 1920, 28853, 2495, 3]}, "items": [{"id": "p_3869", "content": "Vasopressins [SEP] Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balan", "score": 1, "type": null, "tokenized_content": [2, 20671, 1036, 3, 22576, 15766, 10224, 6988, 2007, 1920, 3366, 30338, 7056, 25818, 8362, 1927, 2136, 14976, 12, 3170, 10229, 1956, 3038, 13, 1942, 5741, 3224, 4641, 1928, 3]}]}
{"query": {"id": "q_3870", "content": "halothane [SEP] esthetics form liver adducts and antigens that cross-react with halothane-induced antibodies.", "tokenized_content": [2, 23226, 1963, 2516, 3, 3255, 4116, 2837, 2386, 3568, 16162, 1930, 7769, 1988, 3567, 17, 9793, 1956, 23226, 1963, 2516, 17, 2719, 3788, 18, 3]}, "items": [{"id": "p_3870", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_3871", "content": "enflurane [SEP] Two halogenated anesthetics, enflurane and isoflurane, have been associated with an allergic-type hepa", "tokenized_content": [2, 2066, 12676, 3, 2288, 24778, 1981, 25118, 16, 2066, 12676, 1930, 15362, 16, 2162, 2252, 2458, 1956, 1925, 10519, 17, 2601, 3357, 1019, 3]}, "items": [{"id": "p_3871", "content": "Enflurane [SEP] An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respi", "score": 1, "type": null, "tokenized_content": [2, 2066, 12676, 3, 1925, 8113, 4700, 14728, 16111, 1988, 5731, 4052, 15852, 1927, 8871, 6070, 1956, 5082, 3185, 1922, 7110, 2014, 2163, 1033, 3]}]}
{"query": {"id": "q_3872", "content": "isoflurane [SEP] Two halogenated anesthetics, enflurane and isoflurane, have been associated with an allergic-type hepatic injury both", "tokenized_content": [2, 15362, 3, 2288, 24778, 1981, 25118, 16, 2066, 12676, 1930, 15362, 16, 2162, 2252, 2458, 1956, 1925, 10519, 17, 2601, 6095, 4047, 2321, 3]}, "items": [{"id": "p_3872", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_3873", "content": "hepatic injury [SEP] rane and isoflurane, have been associated with an allergic-type hepatic injury both alone and following previous exposure to halothane. Haloth", "tokenized_content": [2, 6095, 4047, 3, 2845, 1021, 1930, 15362, 16, 2162, 2252, 2458, 1956, 1925, 10519, 17, 2601, 6095, 4047, 2321, 4298, 1930, 2894, 2555, 3395, 1942, 23226, 1963, 2516, 18, 23226, 3]}, "items": [{"id": "p_3873", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3874", "content": "halothane [SEP] pe hepatic injury both alone and following previous exposure to halothane. Halothane hepatitis appears to involve an aberrant immune resp", "tokenized_content": [2, 23226, 1963, 2516, 3, 2737, 6095, 4047, 2321, 4298, 1930, 2894, 2555, 3395, 1942, 23226, 1963, 2516, 18, 23226, 1963, 2516, 7977, 5107, 1942, 8156, 1925, 9801, 3743, 2163, 3]}, "items": [{"id": "p_3874", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_3875", "content": "Halothane [SEP] injury both alone and following previous exposure to halothane. Halothane hepatitis appears to involve an aberrant immune response. An an", "tokenized_content": [2, 23226, 1963, 2516, 3, 4047, 2321, 4298, 1930, 2894, 2555, 3395, 1942, 23226, 1963, 2516, 18, 23226, 1963, 2516, 7977, 5107, 1942, 8156, 1925, 9801, 3743, 2644, 18, 1925, 1925, 3]}, "items": [{"id": "p_3875", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_3876", "content": "hepatitis [SEP] h alone and following previous exposure to halothane. Halothane hepatitis appears to involve an aberrant immune response. An antibody res", "tokenized_content": [2, 7977, 3, 50, 4298, 1930, 2894, 2555, 3395, 1942, 23226, 1963, 2516, 18, 23226, 1963, 2516, 7977, 5107, 1942, 8156, 1925, 9801, 3743, 2644, 18, 1925, 3533, 1995, 3]}, "items": [{"id": "p_3876", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3877", "content": "trifluoroacetyl [SEP] antibody response to a protein-bound biotransformation product (trifluoroacetyl adduct) has been detected on halothane hepatitis patients. This", "tokenized_content": [2, 18560, 15365, 3152, 1024, 3, 3533, 2644, 1942, 43, 2213, 17, 4124, 29176, 28165, 4863, 12, 18560, 15365, 3152, 1024, 18533, 13, 2258, 2252, 3330, 1990, 23226, 1963, 2516, 7977, 3]}, "items": [{"id": "p_3877", "content": "Trifluoroacetic Acid [SEP] A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is ", "score": 1, "type": null, "tokenized_content": [2, 18560, 21117, 2687, 3, 43, 3345, 3206, 24778, 1981, 10533, 1927, 13069, 2687, 18, 2176, 1977, 2251, 1922, 2687, 12139, 5298, 16, 4369, 2690, 2597, 1925, 9603, 1977, 3]}]}
{"query": {"id": "q_3878", "content": "hypersensitivity [SEP] mine cross-reactivity between enflurane and isoflurane with the hypersensitivity induced by halothane. The subcellular and lobular production of", "tokenized_content": [2, 14625, 3, 24165, 3567, 17, 8229, 2192, 2066, 12676, 1930, 15362, 1956, 1920, 14625, 2719, 2007, 23226, 1963, 2516, 18, 1920, 11309, 1930, 28560, 3372, 1927, 3]}, "items": [{"id": "p_3878", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3879", "content": "Enflurane [SEP] ure of these neoantigens was investigated in two animal models. Enflurane administration resulted in neoantigens detected in both the mic", "tokenized_content": [2, 2066, 12676, 3, 6794, 1927, 2144, 11724, 26193, 1036, 1982, 3845, 1922, 2288, 4027, 3130, 18, 2066, 12676, 4183, 4306, 1922, 11724, 26193, 1036, 3330, 1922, 2321, 1920, 2206, 3]}, "items": [{"id": "p_3879", "content": "Enflurane [SEP] An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respi", "score": 1, "type": null, "tokenized_content": [2, 2066, 12676, 3, 1925, 8113, 4700, 14728, 16111, 1988, 5731, 4052, 15852, 1927, 8871, 6070, 1956, 5082, 3185, 1922, 7110, 2014, 2163, 1033, 3]}]}
{"query": {"id": "q_3880", "content": "paracetamol [SEP] Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte ", "tokenized_content": [2, 27021, 3, 4408, 2007, 27021, 1927, 7821, 1930, 3568, 9313, 1922, 1920, 3067, 18, 2564, 1990, 14675, 3]}, "items": [{"id": "p_3880", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_3881", "content": "liver tumours [SEP] Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure.", "tokenized_content": [2, 3568, 9313, 3, 4408, 2007, 27021, 1927, 7821, 1930, 3568, 9313, 1922, 1920, 3067, 18, 2564, 1990, 14675, 8882, 3170, 18, 3]}, "items": [{"id": "p_3881", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3882", "content": "paracetamol [SEP] Leeds strain rats were fed diets containing either 0.5% or 1.0% paracetamol by weight for up to 18 months. At the 1.0% dosage level, 20% of", "tokenized_content": [2, 27021, 3, 10798, 3134, 3943, 3615, 1985, 5788, 10456, 3165, 3108, 20, 18, 25, 9, 2014, 21, 18, 20, 9, 27021, 2007, 3388, 1958, 2353, 1942, 2654, 3221, 18, 2019, 3]}, "items": [{"id": "p_3882", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_3883", "content": "Papillomas [SEP] on, the latter also being observed in the low dosage male rats. Papillomas of the transitional epithelium of the bladder developed in all ", "tokenized_content": [2, 14668, 4956, 3, 1990, 16, 1920, 6296, 2222, 3301, 2528, 1922, 1920, 2330, 9998, 4005, 3615, 18, 14668, 4956, 1927, 1920, 20086, 8081, 1927, 1920, 7821, 3530, 1922, 2136, 3]}, "items": [{"id": "p_3883", "content": "Papilloma [SEP] A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm co", "score": 1, "type": null, "tokenized_content": [2, 14668, 2954, 3, 43, 28868, 6514, 8867, 4944, 2798, 22699, 2037, 1920, 7510, 3154, 31, 2253, 12565, 16, 43, 8867, 4944, 12132, 2081, 3]}]}
{"query": {"id": "q_3884", "content": "bladder carcinomas [SEP] eveloped in all paracetamol-treated groups, and three rats bore bladder carcinomas. However, significant yields of bladder tumours were only obtai", "tokenized_content": [2, 7821, 10691, 3, 2180, 1938, 4907, 1007, 1922, 2136, 27021, 17, 2868, 2671, 16, 1930, 2559, 3615, 25235, 7821, 10691, 18, 2406, 16, 2228, 9243, 1927, 7821, 9313, 1985, 2444, 3]}, "items": [{"id": "p_3884", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3885", "content": "bladder tumours [SEP] ee rats bore bladder carcinomas. However, significant yields of bladder tumours were only obtained from low dosage females and high dosage male", "tokenized_content": [2, 7821, 9313, 3, 11150, 3615, 25235, 7821, 10691, 18, 2406, 16, 2228, 9243, 1927, 7821, 9313, 1985, 2444, 2926, 2037, 2330, 9998, 5027, 1930, 2149, 9998, 4005, 3]}, "items": [{"id": "p_3885", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3886", "content": "hyperplasia [SEP] . Additionally, 20 to 25% of paracetamol-treated rats developed hyperplasia of the bladder epithelium, which was not coincident with the pr", "tokenized_content": [2, 13095, 3, 18, 4950, 16, 2036, 1942, 2637, 9, 1927, 27021, 17, 2868, 3615, 3530, 13095, 1927, 1920, 7821, 8081, 16, 2154, 1982, 2084, 22829, 1956, 1920, 2033, 3]}, "items": [{"id": "p_3886", "content": "Hyperplasia [SEP] An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increa", "score": 1, "type": null, "tokenized_content": [2, 13095, 3, 1925, 2760, 1922, 1920, 2529, 1927, 2094, 1922, 43, 2960, 2014, 3090, 2979, 2798, 3337, 18, 2176, 11457, 2037, 11014, 16, 2154, 1977, 1925, 2203, 1019, 3]}]}
{"query": {"id": "q_3887", "content": "bladder calculi [SEP] adder epithelium, which was not coincident with the presence of bladder calculi. A low yield of tumours at various other sites also arose follo", "tokenized_content": [2, 7821, 2799, 13004, 3, 3019, 1915, 8081, 16, 2154, 1982, 2084, 22829, 1956, 1920, 2990, 1927, 7821, 2799, 13004, 18, 43, 2330, 4307, 1927, 9313, 2019, 3425, 2303, 3402, 2222, 3]}, "items": [{"id": "p_3887", "content": "Urinary Bladder Calculi [SEP] Stones in the URINARY BLADDER; also known as vesical calculi, bladder stones, or cystoliths.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 2799, 13004, 3, 18183, 1922, 1920, 7075, 7821, 31, 2222, 3171, 1966, 5634, 2046, 2799, 13004, 16, 7821, 18183, 16, 2014, 9446, 17895, 1036, 18, 3]}]}
{"query": {"id": "q_3888", "content": "tumours [SEP] bore bladder carcinomas. However, significant yields of bladder tumours were only obtained from low dosage females and high dosage male", "tokenized_content": [2, 9313, 3, 25235, 7821, 10691, 18, 2406, 16, 2228, 9243, 1927, 7821, 9313, 1985, 2444, 2926, 2037, 2330, 9998, 5027, 1930, 2149, 9998, 4005, 3]}, "items": [{"id": "p_3888", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3889", "content": "hepatocarcinogens [SEP]  resemble those that result from exposure to a variety of known hepatocarcinogens.", "tokenized_content": [2, 5746, 7907, 6847, 3, 17212, 2690, 1988, 3211, 2037, 3395, 1942, 43, 5386, 1927, 3171, 5746, 7907, 6847, 18, 3]}, "items": [{"id": "p_3889", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3890", "content": "bupivacaine hydrochloride [SEP] anesthetics that are commonly used in ophthalmic surgery (0.75% bupivacaine hydrochloride, 2.0% mepivacaine hydrochloride, and 2.0% lidocaine hydrochlori", "tokenized_content": [2, 25473, 16675, 3, 25118, 1988, 2032, 5384, 2251, 1922, 21421, 3782, 12, 20, 18, 4089, 9, 25473, 16675, 16, 22, 18, 20, 9, 17257, 20026, 16675, 16, 1930, 22, 18, 3]}, "items": [{"id": "p_3890", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_3891", "content": "mepivacaine hydrochloride [SEP] ed in ophthalmic surgery (0.75% bupivacaine hydrochloride, 2.0% mepivacaine hydrochloride, and 2.0% lidocaine hydrochloride plus 1:100,000 epinephrine) w", "tokenized_content": [2, 17257, 20026, 16675, 3, 3347, 1922, 21421, 3782, 12, 20, 18, 4089, 9, 25473, 16675, 16, 22, 18, 20, 9, 17257, 20026, 16675, 16, 1930, 22, 18, 20, 9, 19567, 3]}, "items": [{"id": "p_3891", "content": "Mepivacaine [SEP] A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for inf", "score": 1, "type": null, "tokenized_content": [2, 17257, 20026, 3, 43, 3076, 16111, 1988, 1977, 13944, 2712, 1942, 25473, 2308, 24645, 2712, 1942, 19567, 18, 2176, 1977, 3391, 1958, 2122, 3]}]}
{"query": {"id": "q_3892", "content": "lidocaine hydrochloride [SEP] vacaine hydrochloride, 2.0% mepivacaine hydrochloride, and 2.0% lidocaine hydrochloride plus 1:100,000 epinephrine) were injected into the retrobulbar ", "tokenized_content": [2, 19567, 16675, 3, 7017, 5966, 16675, 16, 22, 18, 20, 9, 17257, 20026, 16675, 16, 1930, 22, 18, 20, 9, 19567, 16675, 5390, 21, 30, 2813, 16, 3240, 19280, 13, 3]}, "items": [{"id": "p_3892", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3893", "content": "epinephrine [SEP]  hydrochloride, and 2.0% lidocaine hydrochloride plus 1:100,000 epinephrine) were injected into the retrobulbar area of rat eyes. Controls ", "tokenized_content": [2, 19280, 3, 16675, 16, 1930, 22, 18, 20, 9, 19567, 16675, 5390, 21, 30, 2813, 16, 3240, 19280, 13, 1985, 5624, 2460, 1920, 7332, 17909, 1024, 8751, 3403, 1927, 3067, 3]}, "items": [{"id": "p_3893", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3894", "content": "Muscle degeneration [SEP] etics produced massive degeneration of the extraocular muscles. Muscle degeneration is followed by regeneration of the damaged muscle fibers. In ad", "tokenized_content": [2, 3760, 9174, 3, 8096, 2792, 4152, 12944, 9174, 1927, 1920, 8324, 11506, 7848, 18, 3760, 9174, 1977, 3489, 2007, 8596, 1927, 1920, 10756, 3760, 6989, 18, 1922, 2041, 3]}, "items": [{"id": "p_3894", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3895", "content": "muscle damage [SEP] ed by regeneration of the damaged muscle fibers. In addition to muscle damage, severe damage was also seen in harderian glands, especially af", "tokenized_content": [2, 3760, 4293, 3, 3347, 2007, 8596, 1927, 1920, 10756, 3760, 6989, 18, 1922, 2459, 1942, 3760, 4293, 16, 4010, 4293, 1982, 2222, 3945, 1922, 27244, 3122, 11186, 16, 4369, 2221, 3]}, "items": [{"id": "p_3895", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3896", "content": "mepivacaine [SEP] ed in ophthalmic surgery (0.75% bupivacaine hydrochloride, 2.0% mepivacaine hydrochloride, and 2.0% lidocaine hydrochloride plus 1:100,000 ", "tokenized_content": [2, 17257, 20026, 3, 3347, 1922, 21421, 3782, 12, 20, 18, 4089, 9, 25473, 16675, 16, 22, 18, 20, 9, 17257, 20026, 16675, 16, 1930, 22, 18, 20, 9, 19567, 16675, 3]}, "items": [{"id": "p_3896", "content": "Mepivacaine [SEP] A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for inf", "score": 1, "type": null, "tokenized_content": [2, 17257, 20026, 3, 43, 3076, 16111, 1988, 1977, 13944, 2712, 1942, 25473, 2308, 24645, 2712, 1942, 19567, 18, 2176, 1977, 3391, 1958, 2122, 3]}]}
{"query": {"id": "q_3897", "content": "lidocaine [SEP] vacaine hydrochloride, 2.0% mepivacaine hydrochloride, and 2.0% lidocaine hydrochloride plus 1:100,000 epinephrine) were injected into th", "tokenized_content": [2, 19567, 3, 7017, 5966, 16675, 16, 22, 18, 20, 9, 17257, 20026, 16675, 16, 1930, 22, 18, 20, 9, 19567, 16675, 5390, 21, 30, 2813, 16, 3240, 19280, 13, 1985, 3]}, "items": [{"id": "p_3897", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3898", "content": "diplopia [SEP] h these findings in rats, it is hypothesized that the temporary diplopia sometimes seen in patients after ophthalmic surgery might be du", "tokenized_content": [2, 18796, 12105, 3, 50, 2144, 3056, 1922, 3615, 16, 2176, 1977, 7149, 1988, 1920, 15301, 18796, 12105, 8929, 3945, 1922, 2132, 2256, 21421, 3782, 3284, 1998, 4855, 3]}, "items": [{"id": "p_3898", "content": "Diplopia [SEP] A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated", "score": 1, "type": null, "tokenized_content": [2, 18796, 12105, 3, 43, 3737, 3226, 1922, 2154, 43, 2957, 8032, 1977, 6523, 2007, 1920, 3737, 4997, 1966, 2288, 9423, 4356, 2254, 2340, 18, 4414, 2458, 3]}]}
{"query": {"id": "q_3899", "content": "catalepsy [SEP] Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs.", "tokenized_content": [2, 4233, 9431, 1012, 3, 12393, 1927, 20325, 17920, 17, 2719, 4233, 9431, 1012, 2007, 4008, 15578, 17, 16057, 10119, 28932, 4195, 18, 3]}, "items": [{"id": "p_3899", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_3900", "content": "buspirone [SEP] The novel anxiolytic drug, buspirone, reverses catalepsy induced by haloperidol. A series of aryl-pi", "tokenized_content": [2, 11730, 10984, 2830, 1021, 3, 1920, 4008, 28932, 2838, 16, 11730, 10984, 2830, 1021, 16, 28817, 4233, 9431, 1012, 2719, 2007, 25107, 18, 43, 4696, 1927, 15578, 17, 4269, 3]}, "items": [{"id": "p_3900", "content": "Buspirone [SEP] An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unr", "score": 1, "type": null, "tokenized_content": [2, 11730, 10984, 2830, 1021, 3, 1925, 28932, 5899, 1930, 11153, 3148, 7829, 10588, 1942, 1920, 19244, 3508, 10602, 3695, 8337, 1919, 7253, 2921, 1927, 4300, 18, 2496, 3170, 1977, 2067, 1005, 3]}]}
{"query": {"id": "q_3901", "content": "catalepsy [SEP] The novel anxiolytic drug, buspirone, reverses catalepsy induced by haloperidol. A series of aryl-piperazine analogues o", "tokenized_content": [2, 4233, 9431, 1012, 3, 1920, 4008, 28932, 2838, 16, 11730, 10984, 2830, 1021, 16, 28817, 4233, 9431, 1012, 2719, 2007, 25107, 18, 43, 4696, 1927, 15578, 17, 16057, 10119, 13645, 3]}, "items": [{"id": "p_3901", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_3902", "content": "haloperidol [SEP] novel anxiolytic drug, buspirone, reverses catalepsy induced by haloperidol. A series of aryl-piperazine analogues of buspirone and other 5", "tokenized_content": [2, 25107, 3, 4008, 28932, 2838, 16, 11730, 10984, 2830, 1021, 16, 28817, 4233, 9431, 1012, 2719, 2007, 25107, 18, 43, 4696, 1927, 15578, 17, 16057, 10119, 13645, 1927, 11730, 10984, 3]}, "items": [{"id": "p_3902", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3903", "content": "5-hydroxytryptaminergic agonists [SEP] l. A series of aryl-piperazine analogues of buspirone and other 5-hydroxytryptaminergic agonists were tested for their ability to reverse haloperidol induced ca", "tokenized_content": [2, 25, 17, 8275, 30298, 11313, 9849, 3, 54, 18, 43, 4696, 1927, 15578, 17, 16057, 10119, 13645, 1927, 11730, 10984, 2830, 1021, 1930, 2303, 25, 17, 8275, 30298, 11313, 9849, 3]}, "items": [{"id": "p_3903", "content": "Serotonin 5-HT1 Receptor Agonists [SEP] Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists f", "score": 1, "type": null, "tokenized_content": [2, 11153, 25, 17, 5334, 1009, 3148, 9849, 3, 5355, 4300, 1930, 4195, 1988, 4475, 9084, 11153, 25, 17, 5334, 1009, 4086, 18, 3063, 2441, 2052, 26300, 2032, 9849, 48, 3]}]}
{"query": {"id": "q_3904", "content": "5-hydroxytryptamine [SEP] l. A series of aryl-piperazine analogues of buspirone and other 5-hydroxytryptaminergic agonists were tested for their ability to reverse haloperid", "tokenized_content": [2, 25, 17, 8275, 30298, 3812, 3, 54, 18, 43, 4696, 1927, 15578, 17, 16057, 10119, 13645, 1927, 11730, 10984, 2830, 1021, 1930, 2303, 25, 17, 8275, 30298, 11313, 9849, 1985, 3]}, "items": [{"id": "p_3904", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3905", "content": "5-HT [SEP] s were able to reverse catalepsy. Drugs with affinity for other 5-HT receptors or weak affinity were ineffective. However, inhibitio", "tokenized_content": [2, 25, 17, 5334, 3, 61, 1985, 4236, 1942, 5267, 4233, 9431, 1012, 18, 4195, 1956, 5173, 1958, 2303, 25, 17, 5334, 4086, 2014, 5015, 5173, 1985, 15302, 18, 2406, 16, 3]}, "items": [{"id": "p_3905", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3906", "content": "Diazepam [SEP] Diazepam facilitates reflex bradycardia in conscious rats.", "tokenized_content": [2, 26079, 3, 26079, 11374, 11573, 26192, 1922, 11993, 3615, 18, 3]}, "items": [{"id": "p_3906", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_3907", "content": "bradycardia [SEP] Diazepam facilitates reflex bradycardia in conscious rats.", "tokenized_content": [2, 26192, 3, 26079, 11374, 11573, 26192, 1922, 11993, 3615, 18, 3]}, "items": [{"id": "p_3907", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_3908", "content": "diazepam [SEP] The effects of diazepam on cardiovascular function were assessed in conscious rats. Int", "tokenized_content": [2, 26079, 3, 1920, 2564, 1927, 26079, 1990, 5321, 2347, 1985, 3683, 1922, 11993, 3615, 18, 2218, 3]}, "items": [{"id": "p_3908", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_3909", "content": "bradycardia [SEP] oth the mean arterial pressure and the heart rate. Also, reflex bradycardia was produced in rats by intravenous infusion of adrenaline (1.2", "tokenized_content": [2, 26192, 3, 7608, 1023, 1920, 2667, 6624, 3772, 1930, 1920, 4003, 2769, 18, 2222, 16, 11573, 26192, 1982, 4152, 1922, 3615, 2007, 7307, 7386, 1927, 10651, 2053, 12, 21, 18, 3]}, "items": [{"id": "p_3909", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_3910", "content": "adrenaline [SEP] lex bradycardia was produced in rats by intravenous infusion of adrenaline (1.25-2.5 micrograms kg-1). Intravenous pretreatment of the rat", "tokenized_content": [2, 10651, 2053, 3, 14596, 26192, 1982, 4152, 1922, 3615, 2007, 7307, 7386, 1927, 10651, 2053, 12, 21, 18, 2637, 17, 22, 18, 25, 13362, 3621, 17, 21, 13, 18, 7307, 3]}, "items": [{"id": "p_3910", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3911", "content": "picrotoxin [SEP] antagonized by pretreatment of rats with an intravenous dose of picrotoxin (an agent blocks chloride channels by binding to sites associat", "tokenized_content": [2, 7271, 6843, 9754, 3, 29368, 2007, 9111, 1927, 3615, 1956, 1925, 7307, 3253, 1927, 7271, 6843, 9754, 12, 1925, 5899, 7644, 9140, 5628, 2007, 2743, 1942, 3402, 2293, 1926, 3]}, "items": [{"id": "p_3911", "content": "Picrotoxin [SEP] A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated c", "score": 1, "type": null, "tokenized_content": [2, 7271, 6843, 9754, 3, 43, 22849, 9626, 2572, 2320, 8151, 2019, 7992, 17, 43, 4086, 1930, 2842, 43, 4772, 6325, 2031, 18, 7271, 6843, 9754, 7644, 1920, 7034, 17, 29093, 2687, 17, 4128, 45, 3]}]}
{"query": {"id": "q_3912", "content": "chloride [SEP] of rats with an intravenous dose of picrotoxin (an agent blocks chloride channels by binding to sites associated with the benzodiazepine", "tokenized_content": [2, 9140, 3, 1927, 3615, 1956, 1925, 7307, 3253, 1927, 7271, 6843, 9754, 12, 1925, 5899, 7644, 9140, 5628, 2007, 2743, 1942, 3402, 2458, 1956, 1920, 27266, 3]}, "items": [{"id": "p_3912", "content": "Chlorides [SEP] Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9140, 1036, 3, 13849, 4300, 3595, 2037, 14369, 1935, 2687, 1988, 5531, 1920, 2111, 17, 4755, 18, 3]}]}
{"query": {"id": "q_3913", "content": "benzodiazepine [SEP] locks chloride channels by binding to sites associated with the benzodiazepine-GABA-chloride channel macromolecular complex). The data indicat", "tokenized_content": [2, 27266, 3, 12756, 1036, 9140, 5628, 2007, 2743, 1942, 3402, 2458, 1956, 1920, 27266, 17, 7992, 17, 9140, 4999, 21815, 2796, 13, 18, 1920, 2230, 29338, 1031, 3]}, "items": [{"id": "p_3913", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_3914", "content": "GABA [SEP] channels by binding to sites associated with the benzodiazepine-GABA-chloride channel macromolecular complex). The data indicate tha", "tokenized_content": [2, 7992, 3, 5628, 2007, 2743, 1942, 3402, 2458, 1956, 1920, 27266, 17, 7992, 17, 9140, 4999, 21815, 2796, 13, 18, 1920, 2230, 3579, 21513, 3]}, "items": [{"id": "p_3914", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_3915", "content": "carbamazepine [SEP] Chronic carbamazepine inhibits the development of local anesthetic seizures kindled b", "tokenized_content": [2, 30315, 3, 3724, 30315, 7042, 1920, 2740, 1927, 3076, 16111, 10060, 6925, 2824, 44, 3]}, "items": [{"id": "p_3915", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_3916", "content": "seizures [SEP] onic carbamazepine inhibits the development of local anesthetic seizures kindled by cocaine and lidocaine.", "tokenized_content": [2, 10060, 3, 1990, 1935, 30315, 7042, 1920, 2740, 1927, 3076, 16111, 10060, 6925, 2824, 2007, 9045, 1930, 19567, 18, 3]}, "items": [{"id": "p_3916", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3917", "content": "cocaine [SEP] nhibits the development of local anesthetic seizures kindled by cocaine and lidocaine.", "tokenized_content": [2, 9045, 3, 5331, 2023, 2664, 1920, 2740, 1927, 3076, 16111, 10060, 6925, 2824, 2007, 9045, 1930, 19567, 18, 3]}, "items": [{"id": "p_3917", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3918", "content": "lidocaine [SEP] development of local anesthetic seizures kindled by cocaine and lidocaine.", "tokenized_content": [2, 19567, 3, 2740, 1927, 3076, 16111, 10060, 6925, 2824, 2007, 9045, 1930, 19567, 18, 3]}, "items": [{"id": "p_3918", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3919", "content": "carbamazepine [SEP] The effects of carbamazepine (CBZ) treatment on local anesthetic-kindled seizures and lethal", "tokenized_content": [2, 30315, 3, 1920, 2564, 1927, 30315, 12, 5529, 1011, 13, 2311, 1990, 3076, 16111, 17, 6925, 2824, 10060, 1930, 10470, 3]}, "items": [{"id": "p_3919", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_3920", "content": "CBZ [SEP] The effects of carbamazepine (CBZ) treatment on local anesthetic-kindled seizures and lethality w", "tokenized_content": [2, 5529, 1011, 3, 1920, 2564, 1927, 30315, 12, 5529, 1011, 13, 2311, 1990, 3076, 16111, 17, 6925, 2824, 10060, 1930, 15400, 65, 3]}, "items": [{"id": "p_3920", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_3921", "content": "seizures [SEP] ts of carbamazepine (CBZ) treatment on local anesthetic-kindled seizures and lethality were evaluated in different stages of the kindlin", "tokenized_content": [2, 10060, 3, 4894, 1927, 30315, 12, 5529, 1011, 13, 2311, 1990, 3076, 16111, 17, 6925, 2824, 10060, 1930, 15400, 1985, 3747, 1922, 2413, 5143, 1927, 1920, 6925, 7782, 3]}, "items": [{"id": "p_3921", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3922", "content": "lidocaine [SEP] inistration. Chronic oral CBZ inhibited the development of both lidocaine- and cocaine-induced seizures, but had little effect on the ful", "tokenized_content": [2, 19567, 3, 1922, 3934, 18, 3724, 4726, 5529, 1011, 5069, 1920, 2740, 1927, 2321, 19567, 17, 1930, 9045, 17, 2719, 10060, 16, 2308, 2430, 5082, 2495, 1990, 1920, 5257, 3]}, "items": [{"id": "p_3922", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3923", "content": "cocaine [SEP] ronic oral CBZ inhibited the development of both lidocaine- and cocaine-induced seizures, but had little effect on the fully developed ", "tokenized_content": [2, 9045, 3, 25851, 1935, 4726, 5529, 1011, 5069, 1920, 2740, 1927, 2321, 19567, 17, 1930, 9045, 17, 2719, 10060, 16, 2308, 2430, 5082, 2495, 1990, 1920, 5437, 3530, 3]}, "items": [{"id": "p_3923", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3924", "content": "seizure [SEP] ts of carbamazepine (CBZ) treatment on local anesthetic-kindled seizures and lethality were evaluated in different stages of the kindli", "tokenized_content": [2, 11015, 3, 4894, 1927, 30315, 12, 5529, 1011, 13, 2311, 1990, 3076, 16111, 17, 6925, 2824, 10060, 1930, 15400, 1985, 3747, 1922, 2413, 5143, 1927, 1920, 6925, 12191, 3]}, "items": [{"id": "p_3924", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3925", "content": "D-penicillamine [SEP] D-penicillamine in the treatment of localized scleroderma.", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 46, 17, 25142, 3812, 1922, 1920, 2311, 1927, 6579, 8266, 20532, 18, 3]}, "items": [{"id": "p_3925", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3926", "content": "localized scleroderma [SEP] D-penicillamine in the treatment of localized scleroderma.", "tokenized_content": [2, 6579, 8266, 20532, 3, 46, 17, 25142, 3812, 1922, 1920, 2311, 1927, 6579, 8266, 20532, 18, 3]}, "items": [{"id": "p_3926", "content": "Scleroderma, Localized [SEP] A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but", "score": 1, "type": null, "tokenized_content": [2, 8266, 20532, 16, 6579, 3, 43, 2576, 2251, 1942, 5993, 43, 5386, 1927, 6579, 27184, 4407, 16121, 1988, 1977, 2551, 1942, 2690, 1927, 5510, 8266, 20532, 2308, 3]}]}
{"query": {"id": "q_3927", "content": "Localized scleroderma [SEP] Localized scleroderma has no recognized internal organ involvement but may be disfigu", "tokenized_content": [2, 6579, 8266, 20532, 3, 6579, 8266, 20532, 2258, 2239, 6783, 4495, 3090, 5668, 2308, 2278, 1998, 2054, 9344, 1032, 3]}, "items": [{"id": "p_3927", "content": "Scleroderma, Localized [SEP] A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but", "score": 1, "type": null, "tokenized_content": [2, 8266, 20532, 16, 6579, 3, 43, 2576, 2251, 1942, 5993, 43, 5386, 1927, 6579, 27184, 4407, 16121, 1988, 1977, 2551, 1942, 2690, 1927, 5510, 8266, 20532, 2308, 3]}]}
{"query": {"id": "q_3928", "content": "localized scleroderma [SEP] r affect children. There is no accepted or proven treatment for localized scleroderma. Case reports of 11 patients with severe, extensive localized s", "tokenized_content": [2, 6579, 8266, 20532, 3, 60, 4081, 3069, 18, 2276, 1977, 2239, 8131, 2014, 9253, 2311, 1958, 6579, 8266, 20532, 18, 3087, 4710, 1927, 2513, 2132, 1956, 4010, 16, 6475, 6579, 3]}, "items": [{"id": "p_3928", "content": "Scleroderma, Localized [SEP] A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but", "score": 1, "type": null, "tokenized_content": [2, 8266, 20532, 16, 6579, 3, 43, 2576, 2251, 1942, 5993, 43, 5386, 1927, 6579, 27184, 4407, 16121, 1988, 1977, 2551, 1942, 2690, 1927, 5510, 8266, 20532, 2308, 3]}]}
{"query": {"id": "q_3929", "content": "D-penicillamine [SEP] h severe, extensive localized scleroderma who were treated with D-penicillamine are summarized in this article. This drug was judged to have a ", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 50, 4010, 16, 6475, 6579, 8266, 20532, 2746, 1985, 2868, 1956, 46, 17, 25142, 3812, 2032, 8440, 1922, 2052, 5868, 18, 2052, 2838, 1982, 14786, 3]}, "items": [{"id": "p_3929", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3930", "content": "contractures [SEP] th of the affected limb in 2 of 3 children. Joint stiffness and contractures also improved. The dose of D-penicillamine associated with a fa", "tokenized_content": [2, 14456, 2352, 3, 1913, 1927, 1920, 4218, 7755, 1922, 22, 1927, 23, 3069, 18, 6047, 10018, 1930, 14456, 2352, 2222, 4305, 18, 1920, 3253, 1927, 46, 17, 25142, 3812, 2458, 3]}, "items": [{"id": "p_3930", "content": "Contracture [SEP] Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14456, 2027, 3, 7171, 14177, 1927, 1920, 3760, 2014, 2303, 3793, 2960, 4760, 43, 6047, 16, 8444, 5829, 1927, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_3931", "content": "D-Penicillamine [SEP] mg/kg per day given over a period ranging from 15 to 53 months. D-Penicillamine caused nephrotic syndrome in 1 patient and milder reversible pr", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 2786, 19, 3621, 2079, 3007, 3258, 2338, 43, 3047, 6485, 2037, 2461, 1942, 4522, 3221, 18, 46, 17, 25142, 3812, 4189, 29646, 4741, 1922, 21, 3]}, "items": [{"id": "p_3931", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3932", "content": "nephrotic syndrome [SEP] r a period ranging from 15 to 53 months. D-Penicillamine caused nephrotic syndrome in 1 patient and milder reversible proteinuria in 3 other patie", "tokenized_content": [2, 29646, 4741, 3, 60, 43, 3047, 6485, 2037, 2461, 1942, 4522, 3221, 18, 46, 17, 25142, 3812, 4189, 29646, 4741, 1922, 21, 2774, 1930, 23273, 10743, 15831, 1922, 23, 2303, 3]}, "items": [{"id": "p_3932", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3933", "content": "proteinuria [SEP] ne caused nephrotic syndrome in 1 patient and milder reversible proteinuria in 3 other patients; none developed renal insufficiency. These ", "tokenized_content": [2, 15831, 3, 2069, 4189, 29646, 4741, 1922, 21, 2774, 1930, 23273, 10743, 15831, 1922, 23, 2303, 2132, 31, 6046, 3530, 4604, 14566, 18, 2144, 3]}, "items": [{"id": "p_3933", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_3934", "content": "renal insufficiency [SEP] lder reversible proteinuria in 3 other patients; none developed renal insufficiency. These data suggest that D-penicillamine may be effective in se", "tokenized_content": [2, 4604, 14566, 3, 5091, 1915, 10743, 15831, 1922, 23, 2303, 2132, 31, 6046, 3530, 4604, 14566, 18, 2144, 2230, 3220, 1988, 46, 17, 25142, 3812, 2278, 1998, 3655, 1922, 2058, 3]}, "items": [{"id": "p_3934", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3935", "content": "hypotension [SEP] Preservation of renal blood flow during hypotension induced with fenoldopam in dogs.", "tokenized_content": [2, 16453, 3, 12698, 1927, 4604, 2877, 3426, 2409, 16453, 2719, 1956, 15096, 2643, 8228, 1035, 1922, 7894, 18, 3]}, "items": [{"id": "p_3935", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3936", "content": "fenoldopam [SEP] reservation of renal blood flow during hypotension induced with fenoldopam in dogs.", "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 11359, 1943, 1927, 4604, 2877, 3426, 2409, 16453, 2719, 1956, 15096, 2643, 8228, 1035, 1922, 7894, 18, 3]}, "items": [{"id": "p_3936", "content": "Fenoldopam [SEP] A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilati", "score": 1, "type": null, "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 43, 7964, 8524, 3148, 7829, 1988, 1977, 2251, 1966, 1925, 16439, 5899, 18, 2176, 25617, 2877, 3772, 2596, 12480, 4362, 13662, 1968, 3]}]}
{"query": {"id": "q_3937", "content": "hypotension [SEP] The introduction of drugs that could induce hypotension with different pharmacological actions would be advantageous be", "tokenized_content": [2, 16453, 3, 1920, 6935, 1927, 4195, 1988, 2578, 4769, 16453, 1956, 2413, 7683, 7728, 2962, 1998, 16761, 1998, 3]}, "items": [{"id": "p_3937", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3938", "content": "dopamine [SEP] g could be minimized by selecting appropriate therapy. Specific dopamine-1, (DA1) and dopamine-2 (DA2) receptor agonists are now under c", "tokenized_content": [2, 7964, 3, 49, 2578, 1998, 17462, 2007, 12475, 4703, 3181, 18, 2487, 7964, 17, 21, 16, 12, 3692, 1009, 13, 1930, 7964, 17, 22, 12, 3692, 1028, 13, 3148, 9849, 3]}, "items": [{"id": "p_3938", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3939", "content": "DA [SEP] nimized by selecting appropriate therapy. Specific dopamine-1, (DA1) and dopamine-2 (DA2) receptor agonists are now under clinical", "tokenized_content": [2, 3692, 3, 17709, 2301, 2007, 12475, 4703, 3181, 18, 2487, 7964, 17, 21, 16, 12, 3692, 1009, 13, 1930, 7964, 17, 22, 12, 3692, 1028, 13, 3148, 9849, 2032, 5195, 3]}, "items": [{"id": "p_3939", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3940", "content": "Fenoldopam mesylate [SEP] 2 (DA2) receptor agonists are now under clinical investigation. Fenoldopam mesylate is a specific DA1 receptor agonist that lowers blood pressure b", "tokenized_content": [2, 15096, 2643, 8228, 1035, 4438, 9075, 3, 22, 12, 3692, 1028, 13, 3148, 9849, 2032, 5195, 2441, 2535, 5630, 18, 15096, 2643, 8228, 1035, 4438, 9075, 1977, 43, 2487, 3692, 3]}, "items": [{"id": "p_3940", "content": "Fenoldopam [SEP] A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilati", "score": 1, "type": null, "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 43, 7964, 8524, 3148, 7829, 1988, 1977, 2251, 1966, 1925, 16439, 5899, 18, 2176, 25617, 2877, 3772, 2596, 12480, 4362, 13662, 1968, 3]}]}
{"query": {"id": "q_3941", "content": "fenoldopam [SEP] at lowers blood pressure by vasodilatation. The hypothesis that fenoldopam could be used to induce hypotension and preserve blood flow to ", "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 2019, 25617, 2877, 3772, 2007, 13662, 15395, 18, 1920, 4676, 1988, 15096, 2643, 8228, 1035, 2578, 1998, 2251, 1942, 4769, 16453, 1930, 15873, 2877, 3426, 3]}, "items": [{"id": "p_3941", "content": "Fenoldopam [SEP] A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilati", "score": 1, "type": null, "tokenized_content": [2, 15096, 2643, 8228, 1035, 3, 43, 7964, 8524, 3148, 7829, 1988, 1977, 2251, 1966, 1925, 16439, 5899, 18, 2176, 25617, 2877, 3772, 2596, 12480, 4362, 13662, 1968, 3]}]}
{"query": {"id": "q_3942", "content": "sodium [SEP] the cardiovascular and renal vascular effects of fenoldopam and sodium nitroprusside in ten dogs under halothane general anaesthesia. ", "tokenized_content": [2, 5227, 3, 1920, 5321, 1930, 4604, 4541, 2564, 1927, 15096, 2643, 8228, 1035, 1930, 5227, 8686, 2047, 3468, 2261, 1922, 5656, 7894, 2441, 23226, 1963, 2516, 3335, 17107, 18, 3]}, "items": [{"id": "p_3942", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3943", "content": "nitroprusside [SEP] diovascular and renal vascular effects of fenoldopam and sodium nitroprusside in ten dogs under halothane general anaesthesia. Mean arterial ", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 23652, 9521, 1930, 4604, 4541, 2564, 1927, 15096, 2643, 8228, 1035, 1930, 5227, 8686, 2047, 3468, 2261, 1922, 5656, 7894, 2441, 23226, 1963, 2516, 3335, 3]}, "items": [{"id": "p_3943", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_3944", "content": "halothane [SEP] ffects of fenoldopam and sodium nitroprusside in ten dogs under halothane general anaesthesia. Mean arterial pressure was decreased 30 +/", "tokenized_content": [2, 23226, 1963, 2516, 3, 10735, 2284, 1927, 15096, 2643, 8228, 1035, 1930, 5227, 8686, 2047, 3468, 2261, 1922, 5656, 7894, 2441, 23226, 1963, 2516, 3335, 17107, 18, 2667, 6624, 3772, 3]}, "items": [{"id": "p_3944", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_3945", "content": "cibenzoline [SEP] Antiarrhythmic effects of optical isomers of cibenzoline on canine ventricular arrhythmias.", "tokenized_content": [2, 29435, 4389, 8419, 3, 2246, 23246, 4913, 2564, 1927, 6322, 18894, 1927, 29435, 4389, 8419, 1990, 13617, 6493, 16934, 18, 3]}, "items": [{"id": "p_3945", "content": "cifenline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3371, 14946, 3701, 3, 3]}]}
{"query": {"id": "q_3946", "content": "ventricular arrhythmias [SEP] iarrhythmic effects of optical isomers of cibenzoline on canine ventricular arrhythmias.", "tokenized_content": [2, 6493, 16934, 3, 11640, 18858, 10245, 4913, 2564, 1927, 6322, 18894, 1927, 29435, 4389, 8419, 1990, 13617, 6493, 16934, 18, 3]}, "items": [{"id": "p_3946", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3947", "content": "cibenzoline [SEP] Antiarrhythmic effects of (+)-cibenzoline and (-)-cibenzoline were examined using two canine ventricular ", "tokenized_content": [2, 29435, 4389, 8419, 3, 2246, 23246, 4913, 2564, 1927, 12, 15, 13, 17, 29435, 4389, 8419, 1930, 12, 17, 13, 17, 29435, 4389, 8419, 1985, 3572, 2193, 2288, 13617, 6493, 3]}, "items": [{"id": "p_3947", "content": "cifenline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3371, 14946, 3701, 3, 3]}]}
{"query": {"id": "q_3948", "content": "ventricular arrhythmia [SEP] -cibenzoline and (-)-cibenzoline were examined using two canine ventricular arrhythmia models. Digitalis arrhythmia, which is suppressed by Na channel", "tokenized_content": [2, 6493, 18346, 3, 17, 29435, 4389, 8419, 1930, 12, 17, 13, 17, 29435, 4389, 8419, 1985, 3572, 2193, 2288, 13617, 6493, 18346, 3130, 18, 8225, 1937, 18346, 16, 2154, 1977, 3]}, "items": [{"id": "p_3948", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3949", "content": "Digitalis [SEP] e were examined using two canine ventricular arrhythmia models. Digitalis arrhythmia, which is suppressed by Na channel blockers, was ind", "tokenized_content": [2, 8225, 1937, 3, 47, 1985, 3572, 2193, 2288, 13617, 6493, 18346, 3130, 18, 8225, 1937, 18346, 16, 2154, 1977, 7657, 2007, 4049, 4999, 13628, 16, 1982, 2063, 3]}, "items": [{"id": "p_3949", "content": "Digitalis [SEP] A genus of toxic herbaceous Eurasian plants of the SCROPHULARIACEAE which yield cardiotonic DIGITALIS GLYCOSIDES. The most usefu", "score": 1, "type": null, "tokenized_content": [2, 8225, 1937, 3, 43, 9487, 1927, 6161, 11493, 17101, 18180, 6646, 1022, 4793, 1927, 1920, 7572, 2688, 2168, 19476, 2154, 4307, 21129, 24970, 8225, 1937, 28170, 18, 1920, 2501, 2485, 19073, 3]}]}
{"query": {"id": "q_3950", "content": "arrhythmia [SEP]  and (-)-cibenzoline were examined using two canine ventricular arrhythmia models. Digitalis arrhythmia, which is suppressed by Na channel", "tokenized_content": [2, 18346, 3, 1930, 12, 17, 13, 17, 29435, 4389, 8419, 1985, 3572, 2193, 2288, 13617, 6493, 18346, 3130, 18, 8225, 1937, 18346, 16, 2154, 1977, 7657, 2007, 4049, 4999, 3]}, "items": [{"id": "p_3950", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3951", "content": "Na [SEP] arrhythmia models. Digitalis arrhythmia, which is suppressed by Na channel blockers, was induced by intermittent intravenous (i.v.", "tokenized_content": [2, 4049, 3, 18346, 3130, 18, 8225, 1937, 18346, 16, 2154, 1977, 7657, 2007, 4049, 4999, 13628, 16, 1982, 2719, 2007, 13252, 7307, 12, 51, 18, 64, 18, 3]}, "items": [{"id": "p_3951", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3952", "content": "ouabain [SEP] rs, was induced by intermittent intravenous (i.v.) injection of ouabain in pentobarbital-anesthetized dogs. Adrenaline arrhythmia, whic", "tokenized_content": [2, 26274, 3, 4366, 16, 1982, 2719, 2007, 13252, 7307, 12, 51, 18, 64, 18, 13, 4107, 1927, 26274, 1922, 23271, 17, 12137, 7894, 18, 10651, 2053, 18346, 16, 2003, 1935, 3]}, "items": [{"id": "p_3952", "content": "Ouabain [SEP] A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants ", "score": 1, "type": null, "tokenized_content": [2, 26274, 3, 43, 21129, 3849, 7533, 2261, 7600, 1927, 23120, 2217, 1930, 26175, 4079, 1921, 16, 2926, 2037, 1920, 9869, 1927, 4943, 18547, 1963, 1957, 24689, 1031, 1957, 1930, 2303, 4793, 3]}]}
{"query": {"id": "q_3953", "content": "pentobarbital [SEP] uced by intermittent intravenous (i.v.) injection of ouabain in pentobarbital-anesthetized dogs. Adrenaline arrhythmia, which is suppressed b", "tokenized_content": [2, 23271, 3, 8577, 1919, 2007, 13252, 7307, 12, 51, 18, 64, 18, 13, 4107, 1927, 26274, 1922, 23271, 17, 12137, 7894, 18, 10651, 2053, 18346, 16, 2154, 1977, 7657, 44, 3]}, "items": [{"id": "p_3953", "content": "Pentobarbital [SEP] A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given ", "score": 1, "type": null, "tokenized_content": [2, 23271, 3, 43, 3662, 17, 8290, 30434, 4219, 5524, 2057, 1988, 1977, 3655, 1966, 43, 28514, 1930, 25810, 3153, 12, 2308, 2084, 1966, 1925, 2246, 17, 5592, 13, 5899, 1930, 1977, 5394, 3258, 3]}]}
{"query": {"id": "q_3954", "content": "Adrenaline arrhythmia [SEP] (i.v.) injection of ouabain in pentobarbital-anesthetized dogs. Adrenaline arrhythmia, which is suppressed by Ca channel blockers, was induced by adr", "tokenized_content": [2, 10651, 2053, 18346, 3, 12, 51, 18, 64, 18, 13, 4107, 1927, 26274, 1922, 23271, 17, 12137, 7894, 18, 10651, 2053, 18346, 16, 2154, 1977, 7657, 2007, 2332, 4999, 13628, 3]}, "items": [{"id": "p_3954", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3955", "content": "Ca [SEP] nesthetized dogs. Adrenaline arrhythmia, which is suppressed by Ca channel blockers, was induced by adrenaline infusion in halotha", "tokenized_content": [2, 2332, 3, 15681, 4116, 1914, 6756, 7894, 18, 10651, 2053, 18346, 16, 2154, 1977, 7657, 2007, 2332, 4999, 13628, 16, 1982, 2719, 2007, 10651, 2053, 7386, 1922, 23226, 1963, 1019, 3]}, "items": [{"id": "p_3955", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3956", "content": "adrenaline [SEP] mia, which is suppressed by Ca channel blockers, was induced by adrenaline infusion in halothane-anesthetized dogs. Ten and 5 mg/kg i.v. (", "tokenized_content": [2, 10651, 2053, 3, 24173, 16, 2154, 1977, 7657, 2007, 2332, 4999, 13628, 16, 1982, 2719, 2007, 10651, 2053, 7386, 1922, 23226, 1963, 2516, 17, 12137, 7894, 18, 5656, 1930, 25, 3]}, "items": [{"id": "p_3956", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3957", "content": "halothane [SEP] d by Ca channel blockers, was induced by adrenaline infusion in halothane-anesthetized dogs. Ten and 5 mg/kg i.v. (+)-cibenzoline suppres", "tokenized_content": [2, 23226, 1963, 2516, 3, 46, 2007, 2332, 4999, 13628, 16, 1982, 2719, 2007, 10651, 2053, 7386, 1922, 23226, 1963, 2516, 17, 12137, 7894, 18, 5656, 1930, 25, 2786, 19, 3621, 3]}, "items": [{"id": "p_3957", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_3958", "content": "digitalis [SEP] sthetized dogs. Ten and 5 mg/kg i.v. (+)-cibenzoline suppressed digitalis- and adrenaline-induced arrhythmias, respectively. The minimum ", "tokenized_content": [2, 8225, 1937, 3, 1955, 4116, 1914, 6756, 7894, 18, 5656, 1930, 25, 2786, 19, 3621, 51, 18, 64, 18, 12, 15, 13, 17, 29435, 4389, 8419, 7657, 8225, 1937, 17, 3]}, "items": [{"id": "p_3958", "content": "Digitalis [SEP] A genus of toxic herbaceous Eurasian plants of the SCROPHULARIACEAE which yield cardiotonic DIGITALIS GLYCOSIDES. The most usefu", "score": 1, "type": null, "tokenized_content": [2, 8225, 1937, 3, 43, 9487, 1927, 6161, 11493, 17101, 18180, 6646, 1022, 4793, 1927, 1920, 7572, 2688, 2168, 19476, 2154, 4307, 21129, 24970, 8225, 1937, 28170, 18, 1920, 2501, 2485, 19073, 3]}]}
{"query": {"id": "q_3959", "content": "arrhythmias [SEP] v. (+)-cibenzoline suppressed digitalis- and adrenaline-induced arrhythmias, respectively. The minimum effective plasma concentrations of (", "tokenized_content": [2, 16934, 3, 64, 18, 12, 15, 13, 17, 29435, 4389, 8419, 7657, 8225, 1937, 17, 1930, 10651, 2053, 17, 2719, 16934, 16, 2763, 18, 1920, 6081, 3655, 3582, 3295, 1927, 3]}, "items": [{"id": "p_3959", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3960", "content": "Hibiscus rosa sinensis [SEP] Effect of Hibiscus rosa sinensis on reserpine-induced neurobehavioral and biochemical alteration", "tokenized_content": [2, 26823, 10368, 1957, 22424, 27613, 3, 2495, 1927, 26823, 10368, 1957, 22424, 27613, 1990, 1995, 1915, 12184, 17, 2719, 29668, 1930, 6503, 10076, 3]}, "items": [{"id": "p_3960", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_3961", "content": "reserpine [SEP] Effect of Hibiscus rosa sinensis on reserpine-induced neurobehavioral and biochemical alterations in rats.", "tokenized_content": [2, 1995, 1915, 12184, 3, 2495, 1927, 26823, 10368, 1957, 22424, 27613, 1990, 1995, 1915, 12184, 17, 2719, 29668, 1930, 6503, 5996, 1922, 3615, 18, 3]}, "items": [{"id": "p_3961", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3962", "content": "Hibiscus rosa sinensis [SEP] Effect of methanolic extract of Hibiscus rosa sinensis (100-300 mg/kg) was studied on reserpine-induced orofacial dysk", "tokenized_content": [2, 26823, 10368, 1957, 22424, 27613, 3, 2495, 1927, 8570, 1935, 5869, 1927, 26823, 10368, 1957, 22424, 27613, 12, 2813, 17, 5255, 2786, 19, 3621, 13, 1982, 3942, 1990, 1995, 1915, 3]}, "items": [{"id": "p_3962", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_3963", "content": "reserpine [SEP] xtract of Hibiscus rosa sinensis (100-300 mg/kg) was studied on reserpine-induced orofacial dyskinesia and neurochemical alterations. The", "tokenized_content": [2, 1995, 1915, 12184, 3, 23068, 5524, 2341, 1927, 26823, 10368, 1957, 22424, 27613, 12, 2813, 17, 5255, 2786, 19, 3621, 13, 1982, 3942, 1990, 1995, 1915, 12184, 17, 2719, 25027, 3]}, "items": [{"id": "p_3963", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3964", "content": "dyskinesia [SEP] nsis (100-300 mg/kg) was studied on reserpine-induced orofacial dyskinesia and neurochemical alterations. The rats were treated with intra", "tokenized_content": [2, 3890, 26682, 3, 4246, 1937, 12, 2813, 17, 5255, 2786, 19, 3621, 13, 1982, 3942, 1990, 1995, 1915, 12184, 17, 2719, 25027, 18703, 3890, 26682, 1930, 27297, 5996, 18, 1920, 3]}, "items": [{"id": "p_3964", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3965", "content": "Reserpine [SEP] hewing movements and tongue protrusions were counted for 5 min. Reserpine treated rats significantly developed vacuous chewing movements ", "tokenized_content": [2, 1995, 1915, 12184, 3, 2234, 17860, 1029, 8264, 1930, 14761, 23383, 1985, 9007, 1958, 25, 2360, 18, 1995, 1915, 12184, 2868, 3615, 2567, 3530, 8062, 2080, 24394, 8264, 3]}, "items": [{"id": "p_3965", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3966", "content": "superoxide [SEP] nificantly increased lipid peroxidation and decreased levels of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GSH)", "tokenized_content": [2, 10738, 3, 17719, 13611, 14598, 1012, 2502, 4486, 14214, 1930, 3261, 2428, 1927, 10738, 16679, 12, 4546, 13, 16, 14508, 12, 3115, 13, 1930, 9153, 11386, 12, 9973, 13, 3]}, "items": [{"id": "p_3966", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_3967", "content": "glutathione [SEP] reased levels of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GSH), an index of oxidative stress process. Coadmini", "tokenized_content": [2, 9153, 3, 4196, 1919, 2428, 1927, 10738, 16679, 12, 4546, 13, 16, 14508, 12, 3115, 13, 1930, 9153, 11386, 12, 9973, 13, 16, 1925, 3867, 1927, 5163, 3071, 2585, 18, 3]}, "items": [{"id": "p_3967", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_3968", "content": "timolol [SEP] Comparison of aqueous and gellan ophthalmic timolol with placebo on the 24-hour heart rate response in patients on ", "tokenized_content": [2, 2267, 23646, 3, 3723, 1927, 8052, 1930, 4669, 17576, 21421, 2267, 23646, 1956, 5936, 1990, 1920, 2686, 17, 6231, 4003, 2769, 2644, 1922, 2132, 1990, 3]}, "items": [{"id": "p_3968", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_3969", "content": "glaucoma [SEP] on the 24-hour heart rate response in patients on treatment for glaucoma.", "tokenized_content": [2, 12106, 3, 1990, 1920, 2686, 17, 6231, 4003, 2769, 2644, 1922, 2132, 1990, 2311, 1958, 12106, 18, 3]}, "items": [{"id": "p_3969", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_3970", "content": "glaucoma [SEP] treatment is routine therapy in the management of patients with glaucoma. Therapy results in systemic absorption, however, the degree of", "tokenized_content": [2, 12106, 3, 2311, 1977, 7341, 3181, 1922, 1920, 4280, 1927, 2132, 1956, 12106, 18, 3181, 2274, 1922, 5510, 6726, 16, 2406, 16, 1920, 4647, 1927, 3]}, "items": [{"id": "p_3970", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_3971", "content": "timolol [SEP] ESIGN: This trial evaluated the effect of placebo, 0.5% aqueous timolol (timolol solution) and a 0.5% timolol suspension that forms a g", "tokenized_content": [2, 2267, 23646, 3, 11575, 3223, 30, 2052, 3046, 3747, 1920, 2495, 1927, 5936, 16, 20, 18, 25, 9, 8052, 2267, 23646, 12, 2267, 23646, 3331, 13, 1930, 43, 20, 18, 3]}, "items": [{"id": "p_3971", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_3972", "content": "open-angle glaucoma [SEP] eart rate. METHODS: Forty-three Caucasian patients with primary open-angle glaucoma or ocular hypertension with a mean (+/-SD) age of 63 (+/-8) yea", "tokenized_content": [2, 4437, 17, 6524, 12106, 3, 4352, 1031, 2769, 18, 2860, 30, 11270, 17, 2559, 13472, 2132, 1956, 3065, 4437, 17, 6524, 12106, 2014, 10046, 5579, 1956, 43, 2667, 12, 15, 3]}, "items": [{"id": "p_3972", "content": "Glaucoma, Open-Angle [SEP] Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iri", "score": 1, "type": null, "tokenized_content": [2, 12106, 16, 4437, 17, 6524, 3, 12106, 1922, 2154, 1920, 6524, 1927, 1920, 5477, 7329, 1977, 4437, 1930, 1920, 15855, 10238, 3396, 3731, 2084, 3350, 1931, 2155, 1990, 1920, 5170, 1927, 1920, 24768, 3]}]}
{"query": {"id": "q_3973", "content": "ocular hypertension [SEP] ty-three Caucasian patients with primary open-angle glaucoma or ocular hypertension with a mean (+/-SD) age of 63 (+/-8) years were randomized and ", "tokenized_content": [2, 10046, 5579, 3, 6227, 17, 2559, 13472, 2132, 1956, 3065, 4437, 17, 6524, 12106, 2014, 10046, 5579, 1956, 43, 2667, 12, 15, 19, 17, 4035, 13, 2632, 1927, 4968, 12, 3]}, "items": [{"id": "p_3973", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_3974", "content": "Timolol [SEP]  the daytime (-7.5% change in mean heart rate, -5.7 beats/min). Timolol gellan showed a numerically but not significantly smaller reduc", "tokenized_content": [2, 2267, 23646, 3, 1920, 17916, 12, 17, 27, 18, 25, 9, 3185, 1922, 2667, 4003, 2769, 16, 17, 25, 18, 27, 19380, 19, 2360, 13, 18, 2267, 23646, 4669, 17576, 3]}, "items": [{"id": "p_3974", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_3975", "content": "bradycardia [SEP] uring the active daytime period. These data quantify the modest bradycardia associated with ophthalmic beta-blocker therapy in a typical pa", "tokenized_content": [2, 26192, 3, 3674, 1941, 1920, 3500, 17916, 3047, 18, 2144, 2230, 8730, 1920, 9194, 26192, 2458, 1956, 21421, 4666, 17, 14580, 3181, 1922, 43, 5939, 3838, 3]}, "items": [{"id": "p_3975", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_3976", "content": "5 flourouracil [SEP] 5 flourouracil-induced apical ballooning syndrome: a case report.", "tokenized_content": [2, 25, 21028, 20122, 3, 25, 21028, 20122, 17, 2719, 8913, 13819, 1941, 4741, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3976", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_3977", "content": "apical ballooning syndrome [SEP] 5 flourouracil-induced apical ballooning syndrome: a case report.", "tokenized_content": [2, 8913, 13819, 1941, 4741, 3, 25, 21028, 20122, 17, 2719, 8913, 13819, 1941, 4741, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_3977", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_3978", "content": "apical ballooning syndrome [SEP] The apical ballooning syndrome (ABS) is a recently described stress-mediated acute cardiac syn", "tokenized_content": [2, 8913, 13819, 1941, 4741, 3, 1920, 8913, 13819, 1941, 4741, 12, 2872, 13, 1977, 43, 3998, 2910, 3071, 17, 3434, 3939, 4435, 2540, 3]}, "items": [{"id": "p_3978", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_3979", "content": "ABS [SEP] The apical ballooning syndrome (ABS) is a recently described stress-mediated acute cardiac syndrome", "tokenized_content": [2, 2872, 3, 1920, 8913, 13819, 1941, 4741, 12, 2872, 13, 1977, 43, 3998, 2910, 3071, 17, 3434, 3939, 4435, 4741, 3]}, "items": [{"id": "p_3979", "content": "Takotsubo Cardiomyopathy [SEP] A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This ", "score": 1, "type": null, "tokenized_content": [2, 3393, 3882, 2255, 1037, 14141, 3, 43, 6809, 3506, 6493, 8913, 5273, 2014, 13819, 1941, 7936, 2007, 15894, 4158, 12, 11497, 13, 62, 5913, 14825, 1036, 18, 2052, 3]}]}
{"query": {"id": "q_3980", "content": "acute cardiac syndrome [SEP] llooning syndrome (ABS) is a recently described stress-mediated acute cardiac syndrome characterized by transient wall-motion abnormalities involving ", "tokenized_content": [2, 3939, 4435, 4741, 3, 26911, 21184, 4741, 12, 2872, 13, 1977, 43, 3998, 2910, 3071, 17, 3434, 3939, 4435, 4741, 4378, 2007, 6809, 4821, 17, 6269, 6754, 5884, 3]}, "items": [{"id": "p_3980", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_3981", "content": "hyperkinesis [SEP] l-motion abnormalities involving the apex and midventricle with hyperkinesis of the basal left ventricular (LV) segments without obstructive", "tokenized_content": [2, 4194, 23786, 1937, 3, 54, 17, 6269, 6754, 5884, 1920, 14091, 1930, 3953, 5954, 3133, 1952, 1956, 4194, 23786, 1937, 1927, 1920, 5342, 3506, 6493, 12, 6701, 13, 7492, 2979, 3]}, "items": [{"id": "p_3981", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3982", "content": "epicardial coronary disease [SEP] of the basal left ventricular (LV) segments without obstructive epicardial coronary disease. Cardiotoxicity is not an uncommon adverse effect of chemothera", "tokenized_content": [2, 22568, 5846, 2573, 3, 1927, 1920, 5342, 3506, 6493, 12, 6701, 13, 7492, 2979, 12234, 22568, 5846, 2573, 18, 30490, 1977, 2084, 1925, 14403, 5246, 2495, 1927, 12776, 2380, 1019, 3]}, "items": [{"id": "p_3982", "content": "Coronary Disease [SEP] An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow", "score": 1, "type": null, "tokenized_content": [2, 5846, 2573, 3, 1925, 14093, 2192, 6497, 3183, 8456, 1930, 1920, 4796, 1927, 1920, 5846, 7208, 1942, 9042, 5409, 2877, 3426, 3]}]}
{"query": {"id": "q_3983", "content": "Cardiotoxicity [SEP]  (LV) segments without obstructive epicardial coronary disease. Cardiotoxicity is not an uncommon adverse effect of chemotherapeutic agents. H", "tokenized_content": [2, 30490, 3, 12, 6701, 13, 7492, 2979, 12234, 22568, 5846, 2573, 18, 30490, 1977, 2084, 1925, 14403, 5246, 2495, 1927, 14124, 4820, 18, 50, 3]}, "items": [{"id": "p_3983", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3984", "content": "cancer [SEP] an who developed the syndrome after chemotherapy for metastatic cancer. A 79-year-old woman presented with typical ischemic chest pain", "tokenized_content": [2, 2539, 3, 1925, 2746, 3530, 1920, 4741, 2256, 5318, 1958, 6476, 2539, 18, 43, 5637, 17, 2476, 17, 4156, 10440, 3549, 1956, 5939, 7427, 8475, 3594, 3]}, "items": [{"id": "p_3984", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3985", "content": "ischemic [SEP] r metastatic cancer. A 79-year-old woman presented with typical ischemic chest pain, elevated cardiac enzymes with significant ST-segmen", "tokenized_content": [2, 7427, 3, 60, 6476, 2539, 18, 43, 5637, 17, 2476, 17, 4156, 10440, 3549, 1956, 5939, 7427, 8475, 3594, 16, 4664, 4435, 5038, 1956, 2228, 1955, 17, 4133, 19047, 3]}, "items": [{"id": "p_3985", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_3986", "content": "chest pain [SEP] tic cancer. A 79-year-old woman presented with typical ischemic chest pain, elevated cardiac enzymes with significant ST-segment abnormali", "tokenized_content": [2, 8475, 3594, 3, 18298, 2539, 18, 43, 5637, 17, 2476, 17, 4156, 10440, 3549, 1956, 5939, 7427, 8475, 3594, 16, 4664, 4435, 5038, 1956, 2228, 1955, 17, 5367, 4552, 1033, 3]}, "items": [{"id": "p_3986", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_3987", "content": "fluorouracil [SEP] n her electrocardiogram. She underwent recent chemotherapy with fluorouracil for metastatic colorectal cancer. Echocardiography revealed a w", "tokenized_content": [2, 21353, 3, 56, 3656, 22477, 18, 4693, 5468, 3505, 5318, 1956, 21353, 1958, 6476, 7820, 2539, 18, 12814, 3404, 43, 65, 3]}, "items": [{"id": "p_3987", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_3988", "content": "colorectal cancer [SEP]  underwent recent chemotherapy with fluorouracil for metastatic colorectal cancer. Echocardiography revealed a wall-motion abnormality involving ", "tokenized_content": [2, 7820, 2539, 3, 5468, 3505, 5318, 1956, 21353, 1958, 6476, 7820, 2539, 18, 12814, 3404, 43, 4821, 17, 6269, 14311, 5884, 3]}, "items": [{"id": "p_3988", "content": "Colorectal Neoplasms [SEP] Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMI", "score": 1, "type": null, "tokenized_content": [2, 7820, 15347, 3, 3861, 2014, 2539, 1927, 1920, 4120, 2014, 1920, 19773, 2014, 2321, 18, 2565, 2790, 1958, 7820, 2539, 3951, 3724, 20428, 12087, 31, 3011, 1033, 3]}]}
{"query": {"id": "q_3989", "content": "akinetic [SEP] ity involving the apical and periapical segments which appeared akinetic. Coronary angiography revealed no obstructive coronary lesions.", "tokenized_content": [2, 26162, 3023, 3, 2176, 1012, 5884, 1920, 8913, 1930, 2953, 28916, 7492, 2154, 6209, 26162, 3023, 18, 5846, 11676, 3404, 2239, 12234, 5846, 4518, 18, 3]}, "items": [{"id": "p_3989", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_3990", "content": "akinesis [SEP] ealed a normal ejection fraction and a resolution of the apical akinesis. Pathogenetic mechanisms of cardiac complications in cancer pat", "tokenized_content": [2, 26162, 2600, 3, 11377, 2824, 43, 2791, 13854, 3906, 1930, 43, 4885, 1927, 1920, 8913, 26162, 2600, 18, 7055, 3023, 3531, 1927, 4435, 5021, 1922, 2539, 2917, 3]}, "items": [{"id": "p_3990", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_3991", "content": "cardiac complications [SEP] a resolution of the apical akinesis. Pathogenetic mechanisms of cardiac complications in cancer patients undergoing chemotherapy include coronary vas", "tokenized_content": [2, 4435, 5021, 3, 43, 4885, 1927, 1920, 8913, 26162, 2600, 18, 7055, 3023, 3531, 1927, 4435, 5021, 1922, 2539, 2132, 7258, 5318, 3951, 5846, 6350, 3]}, "items": [{"id": "p_3991", "content": "Cardiac Complexes, Premature [SEP] A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atr", "score": 1, "type": null, "tokenized_content": [2, 4435, 5048, 16, 9839, 3, 43, 2210, 1927, 4435, 16934, 1922, 2154, 1920, 4435, 15465, 2032, 2084, 7796, 2019, 1920, 3132, 6952, 17075, 6267, 18, 2611, 3951, 2321, 6204, 3]}]}
{"query": {"id": "q_3992", "content": "coronary vasospasm [SEP] omplications in cancer patients undergoing chemotherapy include coronary vasospasm, endothelial damage and consequent thrombus formation. In our p", "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 21921, 3742, 2082, 1922, 2539, 2132, 7258, 5318, 3951, 5846, 22866, 3508, 2691, 16, 5003, 4293, 1930, 16693, 16705, 3337, 18, 1922, 2342, 58, 3]}, "items": [{"id": "p_3992", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_3993", "content": "thrombus [SEP] y include coronary vasospasm, endothelial damage and consequent thrombus formation. In our patient, both supraphysiologic levels of plas", "tokenized_content": [2, 16705, 3, 67, 3951, 5846, 22866, 3508, 2691, 16, 5003, 4293, 1930, 16693, 16705, 3337, 18, 1922, 2342, 2774, 16, 2321, 21038, 25818, 12924, 4467, 2428, 1927, 16609, 3]}, "items": [{"id": "p_3993", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_3994", "content": "catecholamines [SEP] rmation. In our patient, both supraphysiologic levels of plasma catecholamines and stress related neuropeptides caused by cancer diagnosis as ", "tokenized_content": [2, 25923, 3, 10625, 1943, 18, 1922, 2342, 2774, 16, 2321, 21038, 25818, 12924, 4467, 2428, 1927, 3582, 25923, 1930, 3071, 2712, 26839, 4189, 2007, 2539, 3574, 1966, 3]}, "items": [{"id": "p_3994", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_3995", "content": "pain [SEP] Reduction of pain during induction with target-controlled propofol and remifentan", "tokenized_content": [2, 3594, 3, 3378, 1927, 3594, 2409, 4408, 1956, 2758, 17, 4642, 16615, 1930, 2500, 10528, 4905, 1928, 3]}, "items": [{"id": "p_3995", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3996", "content": "propofol [SEP] Reduction of pain during induction with target-controlled propofol and remifentanil.", "tokenized_content": [2, 16615, 3, 3378, 1927, 3594, 2409, 4408, 1956, 2758, 17, 4642, 16615, 1930, 2500, 10528, 4905, 16692, 18, 3]}, "items": [{"id": "p_3996", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_3997", "content": "remifentanil [SEP] on of pain during induction with target-controlled propofol and remifentanil.", "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 1990, 1927, 3594, 2409, 4408, 1956, 2758, 17, 4642, 16615, 1930, 2500, 10528, 4905, 16692, 18, 3]}, "items": [{"id": "p_3997", "content": "remifentanil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 3]}]}
{"query": {"id": "q_3998", "content": "Pain [SEP] BACKGROUND: Pain on injection of propofol is unpleasant. We hypothesized that pr", "tokenized_content": [2, 3594, 3, 3872, 30, 3594, 1990, 4107, 1927, 16615, 1977, 25429, 18, 2038, 7149, 1988, 2033, 3]}, "items": [{"id": "p_3998", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3999", "content": "propofol [SEP] BACKGROUND: Pain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain migh", "tokenized_content": [2, 16615, 3, 3872, 30, 3594, 1990, 4107, 1927, 16615, 1977, 25429, 18, 2038, 7149, 1988, 16615, 7386, 3594, 22161, 1023, 3]}, "items": [{"id": "p_3999", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_4000", "content": "pain [SEP]  propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the", "tokenized_content": [2, 3594, 3, 16615, 1977, 25429, 18, 2038, 7149, 1988, 16615, 7386, 3594, 3284, 1998, 8715, 2007, 2122, 16435, 2500, 10528, 4905, 16692, 3119, 6801, 1920, 3]}, "items": [{"id": "p_4000", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4001", "content": "remifentanil [SEP] ized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting whe", "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 25455, 1919, 1988, 16615, 7386, 3594, 3284, 1998, 8715, 2007, 2122, 16435, 2500, 10528, 4905, 16692, 3119, 6801, 1920, 16615, 7386, 1922, 43, 2535, 4308, 3]}, "items": [{"id": "p_4001", "content": "remifentanil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 3]}]}
{"query": {"id": "q_4002", "content": "Remifentanil [SEP] e target Ce was achieved, the infusion of propofol was started. Remifentanil-related complications were assessed during the remifentanil inf", "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 47, 2758, 5827, 1982, 5032, 16, 1920, 7386, 1927, 16615, 1982, 8074, 18, 2500, 10528, 4905, 16692, 17, 2712, 5021, 1985, 3683, 2409, 1920, 2500, 3]}, "items": [{"id": "p_4002", "content": "remifentanil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2500, 10528, 4905, 16692, 3, 3]}]}
{"query": {"id": "q_4003", "content": "fluoxetine [SEP] Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.", "tokenized_content": [2, 22176, 3, 10907, 3395, 1942, 22176, 6387, 5944, 5352, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4003", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_4004", "content": "fetal pulmonary hypertension [SEP] Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.", "tokenized_content": [2, 5944, 5352, 5579, 3, 10907, 3395, 1942, 22176, 6387, 5944, 5352, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4004", "content": "Fetal Diseases [SEP] Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5944, 3902, 3, 15421, 2961, 1927, 1920, 15722, 1922, 1920, 16297, 18, 2673, 5944, 3902, 2278, 1998, 2868, 1956, 5944, 6565, 18, 3]}]}
{"query": {"id": "q_4005", "content": "pulmonary hypertension [SEP] Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.", "tokenized_content": [2, 5352, 5579, 3, 10907, 3395, 1942, 22176, 6387, 5944, 5352, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4005", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_4006", "content": "Fluoxetine [SEP] RATIONALE: Fluoxetine is a selective serotonin reuptake inhibitor antidepressant wide", "tokenized_content": [2, 22176, 3, 13202, 30, 22176, 1977, 43, 5328, 11153, 22957, 4106, 14183, 4743, 3]}, "items": [{"id": "p_4006", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_4007", "content": "serotonin [SEP] RATIONALE: Fluoxetine is a selective serotonin reuptake inhibitor antidepressant widely used by pregnant women", "tokenized_content": [2, 11153, 3, 13202, 30, 22176, 1977, 43, 5328, 11153, 22957, 4106, 14183, 5673, 2251, 2007, 7808, 3089, 3]}, "items": [{"id": "p_4007", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4008", "content": "fluoxetine [SEP] idely used by pregnant women. Epidemiological data suggest that fluoxetine exposure prenatally increases the prevalence of persistent pulm", "tokenized_content": [2, 22176, 3, 9043, 1954, 2251, 2007, 7808, 3089, 18, 9591, 2230, 3220, 1988, 22176, 3395, 10907, 1954, 4041, 1920, 4077, 1927, 7733, 3784, 1035, 3]}, "items": [{"id": "p_4008", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_4009", "content": "pulmonary hypertension syndrome [SEP] tine exposure prenatally increases the prevalence of persistent pulmonary hypertension syndrome of the newborn. The mechanism responsible for this effect is un", "tokenized_content": [2, 5352, 5579, 4741, 3, 12347, 1021, 3395, 10907, 1954, 4041, 1920, 4077, 1927, 7733, 5352, 5579, 4741, 1927, 1920, 12203, 18, 1920, 2856, 5061, 1958, 2052, 2495, 1977, 2067, 3]}, "items": [{"id": "p_4009", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_4010", "content": "pulmonary hypertension [SEP] tine exposure prenatally increases the prevalence of persistent pulmonary hypertension syndrome of the newborn. The mechanism responsible for this eff", "tokenized_content": [2, 5352, 5579, 3, 12347, 1021, 3395, 10907, 1954, 4041, 1920, 4077, 1927, 7733, 5352, 5579, 4741, 1927, 1920, 12203, 18, 1920, 2856, 5061, 1958, 2052, 2121, 3]}, "items": [{"id": "p_4010", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_4011", "content": "fetal pulmonary hypertension [SEP] ion. As compared with controls, fluoxetine exposure resulted in fetal pulmonary hypertension as evidenced by an increase in the weight ratio of the right ve", "tokenized_content": [2, 5944, 5352, 5579, 3, 4755, 18, 1966, 2452, 1956, 3562, 16, 22176, 3395, 4306, 1922, 5944, 5352, 5579, 1966, 11400, 2007, 1925, 2760, 1922, 1920, 3388, 3400, 1927, 1920, 3659, 3]}, "items": [{"id": "p_4011", "content": "Fetal Diseases [SEP] Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5944, 3902, 3, 15421, 2961, 1927, 1920, 15722, 1922, 1920, 16297, 18, 2673, 5944, 3902, 2278, 1998, 2868, 1956, 5944, 6565, 18, 3]}]}
{"query": {"id": "q_4012", "content": "oxygen [SEP] ortality was increased among experimental animals, and arterial oxygen saturation was 96 +/- 1% in 1-day-old control animals and signi", "tokenized_content": [2, 4612, 3, 2014, 2381, 1999, 1982, 2502, 2706, 3599, 3555, 16, 1930, 6624, 4612, 10113, 1982, 4746, 15, 19, 17, 21, 9, 1922, 21, 17, 3007, 17, 4156, 2285, 3555, 3]}, "items": [{"id": "p_4012", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_4013", "content": "Syncope [SEP] Syncope and QT prolongation among patients treated with methadone for h", "tokenized_content": [2, 26742, 3, 26742, 1930, 8877, 20334, 2706, 2132, 2868, 1956, 20293, 1958, 50, 3]}, "items": [{"id": "p_4013", "content": "Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync", "score": 1, "type": null, "tokenized_content": [2, 26742, 3, 43, 6809, 3257, 1927, 16897, 1930, 17198, 11020, 4189, 2007, 9597, 2877, 3426, 1942, 1920, 3068, 12, 51, 18, 47, 18, 16, 3068, 7716, 13, 18, 2244, 2304, 1030, 3]}]}
{"query": {"id": "q_4014", "content": "QT prolongation [SEP] Syncope and QT prolongation among patients treated with methadone for heroin dependence in ", "tokenized_content": [2, 8877, 20334, 3, 26742, 1930, 8877, 20334, 2706, 2132, 2868, 1956, 20293, 1958, 19175, 6816, 1922, 3]}, "items": [{"id": "p_4014", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_4015", "content": "methadone [SEP] Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen.", "tokenized_content": [2, 20293, 3, 26742, 1930, 8877, 20334, 2706, 2132, 2868, 1956, 20293, 1958, 19175, 6816, 1922, 1920, 8318, 1927, 16955, 21677, 4079, 18, 3]}, "items": [{"id": "p_4015", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_4016", "content": "heroin [SEP] e and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen.", "tokenized_content": [2, 19175, 3, 47, 1930, 8877, 20334, 2706, 2132, 2868, 1956, 20293, 1958, 19175, 6816, 1922, 1920, 8318, 1927, 16955, 21677, 4079, 18, 3]}, "items": [{"id": "p_4016", "content": "Heroin [SEP] A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Feder", "score": 1, "type": null, "tokenized_content": [2, 19175, 3, 43, 22872, 3153, 14501, 1988, 2278, 1998, 7954, 17, 7402, 18, 2176, 1977, 43, 4642, 7311, 12, 7976, 1989, 10533, 13, 7663, 1922, 1920, 63, 18, 61, 18, 7815, 1927, 5788, 1915, 3]}]}
{"query": {"id": "q_4017", "content": "Methadone [SEP] BACKGROUND: Methadone is prescribed to heroin addicts to decrease illicit opioid use.", "tokenized_content": [2, 20293, 3, 3872, 30, 20293, 1977, 9975, 1942, 19175, 16888, 1973, 1942, 3714, 20881, 9384, 2485, 18, 3]}, "items": [{"id": "p_4017", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_4018", "content": "heroin [SEP] BACKGROUND: Methadone is prescribed to heroin addicts to decrease illicit opioid use. Prolongation of the QT ", "tokenized_content": [2, 19175, 3, 3872, 30, 20293, 1977, 9975, 1942, 19175, 16888, 1973, 1942, 3714, 20881, 9384, 2485, 18, 20334, 1927, 1920, 8877, 3]}, "items": [{"id": "p_4018", "content": "Heroin [SEP] A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Feder", "score": 1, "type": null, "tokenized_content": [2, 19175, 3, 43, 22872, 3153, 14501, 1988, 2278, 1998, 7954, 17, 7402, 18, 2176, 1977, 43, 4642, 7311, 12, 7976, 1989, 10533, 13, 7663, 1922, 1920, 63, 18, 61, 18, 7815, 1927, 5788, 1915, 3]}]}
{"query": {"id": "q_4019", "content": "torsade de pointes [SEP] se. Prolongation of the QT interval in the ECG of patients with torsade de pointes (TdP) has been reported in methadone users. As heroin addicts s", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 2058, 18, 20334, 1927, 1920, 8877, 4979, 1922, 1920, 11497, 1927, 2132, 1956, 14823, 2873, 2028, 3575, 1918, 12, 15390, 13, 2258, 2252, 2568, 3]}, "items": [{"id": "p_4019", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_4020", "content": "TdP [SEP] the QT interval in the ECG of patients with torsade de pointes (TdP) has been reported in methadone users. As heroin addicts someti", "tokenized_content": [2, 15390, 3, 1920, 8877, 4979, 1922, 1920, 11497, 1927, 2132, 1956, 14823, 2873, 2028, 3575, 1918, 12, 15390, 13, 2258, 2252, 2568, 1922, 20293, 6603, 18, 1966, 19175, 16888, 1973, 3]}, "items": [{"id": "p_4020", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_4021", "content": "methadone [SEP]  of patients with torsade de pointes (TdP) has been reported in methadone users. As heroin addicts sometimes faint while using illicit dr", "tokenized_content": [2, 20293, 3, 1927, 2132, 1956, 14823, 2873, 2028, 3575, 1918, 12, 15390, 13, 2258, 2252, 2568, 1922, 20293, 6603, 18, 1966, 19175, 16888, 1973, 8929, 26589, 2679, 2193, 20881, 2324, 3]}, "items": [{"id": "p_4021", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_4022", "content": "syncope [SEP] ing illicit drugs, doctors might attribute too many episodes of syncope to illicit drug use and thereby underestimate the incidence of ", "tokenized_content": [2, 26742, 3, 30393, 20881, 4195, 16, 11849, 3284, 16008, 7405, 3086, 9232, 1927, 26742, 1942, 20881, 2838, 2485, 1930, 6113, 21772, 1920, 4332, 1927, 3]}, "items": [{"id": "p_4022", "content": "Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync", "score": 1, "type": null, "tokenized_content": [2, 26742, 3, 43, 6809, 3257, 1927, 16897, 1930, 17198, 11020, 4189, 2007, 9597, 2877, 3426, 1942, 1920, 3068, 12, 51, 18, 47, 18, 16, 3068, 7716, 13, 18, 2244, 2304, 1030, 3]}]}
{"query": {"id": "q_4023", "content": "buprenorphine [SEP]  a population of adult heroin addicts treated with methadone or buprenorphine on a daily basis. Of the patients at the Drug Addiction Service", "tokenized_content": [2, 23112, 3, 43, 2973, 1927, 4160, 19175, 16888, 1973, 2868, 1956, 20293, 2014, 23112, 1990, 43, 4692, 4859, 18, 1927, 1920, 2132, 2019, 1920, 2838, 12067, 5948, 3]}, "items": [{"id": "p_4023", "content": "Buprenorphine [SEP] A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act", "score": 1, "type": null, "tokenized_content": [2, 23112, 3, 43, 10533, 1927, 1920, 9384, 29951, 1920, 7972, 2053, 1988, 1977, 43, 2253, 6828, 1930, 4872, 11671, 14501, 2254, 11553, 18, 2176, 5107, 1942, 4033, 3]}]}
{"query": {"id": "q_4024", "content": "prolonged QTc interval [SEP]  the subjects treated with methadone, 28% men and 32% women had prolonged QTc interval. None of the subjects treated with buprenorphine had QTc interv", "tokenized_content": [2, 7171, 23946, 4979, 3, 1920, 3297, 2868, 1956, 20293, 16, 3158, 9, 3925, 1930, 3323, 9, 3089, 2430, 7171, 23946, 4979, 18, 6046, 1927, 1920, 3297, 2868, 1956, 23112, 2430, 3]}, "items": [{"id": "p_4024", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_4025", "content": "QT prolongation [SEP] her odds for syncope. CONCLUSIONS: Methadone is associated with QT prolongation and higher reporting of syncope in a population of heroin addic", "tokenized_content": [2, 8877, 20334, 3, 3656, 6408, 1958, 26742, 18, 4355, 30, 20293, 1977, 2458, 1956, 8877, 20334, 1930, 2580, 6605, 1927, 26742, 1922, 43, 2973, 1927, 19175, 16888, 3]}, "items": [{"id": "p_4025", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_4026", "content": "Peripheral neuropathy [SEP] Peripheral neuropathy caused by high-dose cytosine arabinoside treatment in a patient", "tokenized_content": [2, 5009, 13177, 3, 5009, 13177, 4189, 2007, 2149, 17, 3253, 19032, 20790, 8028, 2311, 1922, 43, 2774, 3]}, "items": [{"id": "p_4026", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4027", "content": "cytosine arabinoside [SEP] Peripheral neuropathy caused by high-dose cytosine arabinoside treatment in a patient with acute myeloid leukemia.", "tokenized_content": [2, 19032, 20790, 8028, 3, 5009, 13177, 4189, 2007, 2149, 17, 3253, 19032, 20790, 8028, 2311, 1922, 43, 2774, 1956, 3939, 9677, 8111, 18, 3]}, "items": [{"id": "p_4027", "content": "Cytarabine [SEP] A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cy", "score": 1, "type": null, "tokenized_content": [2, 2702, 23649, 3, 43, 21611, 18015, 5729, 1988, 1977, 2251, 4994, 1922, 1920, 2311, 1927, 8111, 16, 4369, 3939, 2447, 17, 24403, 8111, 18, 6002, 3]}]}
{"query": {"id": "q_4028", "content": "acute myeloid leukemia [SEP] d by high-dose cytosine arabinoside treatment in a patient with acute myeloid leukemia.", "tokenized_content": [2, 3939, 9677, 8111, 3, 46, 2007, 2149, 17, 3253, 19032, 20790, 8028, 2311, 1922, 43, 2774, 1956, 3939, 9677, 8111, 18, 3]}, "items": [{"id": "p_4028", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_4029", "content": "toxicity [SEP] The central nervous system toxicity of high-dose cytosine arabinoside is well recognized, but the t", "tokenized_content": [2, 5532, 3, 1920, 4101, 7580, 2433, 5532, 1927, 2149, 17, 3253, 19032, 20790, 8028, 1977, 2486, 6783, 16, 2308, 1920, 62, 3]}, "items": [{"id": "p_4029", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4030", "content": "cytosine arabinoside [SEP] The central nervous system toxicity of high-dose cytosine arabinoside is well recognized, but the toxicity of cytosine arabinoside in", "tokenized_content": [2, 19032, 20790, 8028, 3, 1920, 4101, 7580, 2433, 5532, 1927, 2149, 17, 3253, 19032, 20790, 8028, 1977, 2486, 6783, 16, 2308, 1920, 5532, 1927, 19032, 20790, 8028, 1922, 3]}, "items": [{"id": "p_4030", "content": "Cytarabine [SEP] A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cy", "score": 1, "type": null, "tokenized_content": [2, 2702, 23649, 3, 43, 21611, 18015, 5729, 1988, 1977, 2251, 4994, 1922, 1920, 2311, 1927, 8111, 16, 4369, 3939, 2447, 17, 24403, 8111, 18, 6002, 3]}]}
{"query": {"id": "q_4031", "content": "acute myeloid leukemia [SEP] quently reported. A 49-year-old Japanese man was diagnosed with acute myeloid leukemia. After he achieved complete remission, he received high-dose cy", "tokenized_content": [2, 3939, 9677, 8111, 3, 10730, 4905, 1954, 2568, 18, 43, 4343, 17, 2476, 17, 4156, 10405, 2323, 1982, 5377, 1956, 3939, 9677, 8111, 18, 2256, 2234, 5032, 4080, 10221, 16, 3]}, "items": [{"id": "p_4031", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_4032", "content": "numbness [SEP] 21 of the second course of treatment, the patient complained of numbness in his right foot. Electromyogram and nerve-conduction studies ", "tokenized_content": [2, 25646, 2971, 3, 2900, 1927, 1920, 2812, 4914, 1927, 2311, 16, 1920, 2774, 26199, 1927, 25646, 2971, 1922, 4167, 3659, 8135, 18, 22755, 7539, 1930, 5507, 17, 12382, 2351, 3]}, "items": [{"id": "p_4032", "content": "Hypesthesia [SEP] Absent or reduced sensitivity to cutaneous stimulation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2483, 29259, 3, 7685, 2014, 3028, 3802, 1942, 11276, 4177, 18, 3]}]}
{"query": {"id": "q_4033", "content": "peripheral neuropathy [SEP]  right foot. Electromyogram and nerve-conduction studies showed peripheral neuropathy in both peroneal nerves. This neuropathy was gradually resolvin", "tokenized_content": [2, 5009, 13177, 3, 3659, 8135, 18, 22755, 7539, 1930, 5507, 17, 12382, 2351, 2594, 5009, 13177, 1922, 2321, 2079, 2290, 1923, 12014, 18, 2052, 13177, 1982, 9690, 24321, 11800, 3]}, "items": [{"id": "p_4033", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4034", "content": "neuropathy [SEP] . Electromyogram and nerve-conduction studies showed peripheral neuropathy in both peroneal nerves. This neuropathy was gradually resolvin", "tokenized_content": [2, 13177, 3, 18, 22755, 7539, 1930, 5507, 17, 12382, 2351, 2594, 5009, 13177, 1922, 2321, 2079, 2290, 1923, 12014, 18, 2052, 13177, 1982, 9690, 24321, 11800, 3]}, "items": [{"id": "p_4034", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4035", "content": "graft-versus-host disease [SEP] transplantation, the symptoms worsened, with the development of graft-versus-host disease, and the symptoms subsequently responded to methylprednisolone.", "tokenized_content": [2, 7668, 17, 4072, 17, 4423, 2573, 3, 6530, 16, 1920, 3601, 22784, 16, 1956, 1920, 2740, 1927, 7668, 17, 4072, 17, 4423, 2573, 16, 1930, 1920, 3601, 5326, 10711, 1942, 3]}, "items": [{"id": "p_4035", "content": "Graft vs Host Disease [SEP] The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eve", "score": 1, "type": null, "tokenized_content": [2, 7668, 3201, 4423, 2573, 3, 1920, 2535, 14866, 4378, 2007, 21810, 16, 11904, 16, 3257, 1927, 7018, 16, 5104, 12903, 16, 17100, 16, 2905, 16342, 16, 1930, 2180, 1021, 3]}]}
{"query": {"id": "q_4036", "content": "methylprednisolone [SEP] versus-host disease, and the symptoms subsequently responded to methylprednisolone. Although the mechanisms of peripheral neuropathy are still unc", "tokenized_content": [2, 30087, 3, 4072, 17, 4423, 2573, 16, 1930, 1920, 3601, 5326, 10711, 1942, 30087, 18, 2876, 1920, 3531, 1927, 5009, 13177, 2032, 3974, 5269, 3]}, "items": [{"id": "p_4036", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_4037", "content": "Atorvastatin [SEP] Atorvastatin prevented and reversed dexamethasone-induced hypertension in th", "tokenized_content": [2, 23489, 3, 23489, 8715, 1930, 9432, 12681, 17, 2719, 5579, 1922, 1913, 3]}, "items": [{"id": "p_4037", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_4038", "content": "dexamethasone [SEP] Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.", "tokenized_content": [2, 12681, 3, 23489, 8715, 1930, 9432, 12681, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4038", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4039", "content": "hypertension [SEP] Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.", "tokenized_content": [2, 5579, 3, 23489, 8715, 1930, 9432, 12681, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4039", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4040", "content": "atorvastatin [SEP] To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male S", "tokenized_content": [2, 23489, 3, 1942, 2634, 1920, 7335, 2564, 1927, 23489, 12, 22973, 7302, 13, 1990, 12681, 12, 7473, 13, 17, 2719, 5579, 16, 3276, 4005, 61, 3]}, "items": [{"id": "p_4040", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_4041", "content": "atorva [SEP] To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 ", "tokenized_content": [2, 22973, 7302, 3, 1942, 2634, 1920, 7335, 2564, 1927, 23489, 12, 22973, 7302, 13, 1990, 12681, 12, 7473, 13, 17, 2719, 5579, 16, 3276, 3]}, "items": [{"id": "p_4041", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_4042", "content": "dexamethasone [SEP] To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were tr", "tokenized_content": [2, 12681, 3, 1942, 2634, 1920, 7335, 2564, 1927, 23489, 12, 22973, 7302, 13, 1990, 12681, 12, 7473, 13, 17, 2719, 5579, 16, 3276, 4005, 15684, 17, 15798, 3615, 1985, 2025, 3]}, "items": [{"id": "p_4042", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4043", "content": "dex [SEP] To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley ra", "tokenized_content": [2, 7473, 3, 1942, 2634, 1920, 7335, 2564, 1927, 23489, 12, 22973, 7302, 13, 1990, 12681, 12, 7473, 13, 17, 2719, 5579, 16, 3276, 4005, 15684, 17, 15798, 4313, 3]}, "items": [{"id": "p_4043", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4044", "content": "hypertension [SEP] effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/", "tokenized_content": [2, 5579, 3, 2564, 1927, 23489, 12, 22973, 7302, 13, 1990, 12681, 12, 7473, 13, 17, 2719, 5579, 16, 3276, 4005, 15684, 17, 15798, 3615, 1985, 2868, 1956, 22973, 7302, 2627, 3]}, "items": [{"id": "p_4044", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4045", "content": "Dex [SEP] were treated with atorva 30 mg/kg/day or tap water for 15 days. Dex increased systolic blood pressure (SBP) from 109 +/- 1.8 to 135", "tokenized_content": [2, 7473, 3, 1985, 2868, 1956, 22973, 7302, 2627, 2786, 19, 3621, 19, 3007, 2014, 10167, 3224, 1958, 2461, 3000, 18, 7473, 2502, 8541, 2877, 3772, 12, 12345, 13, 2037, 9359, 3]}, "items": [{"id": "p_4045", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4046", "content": "superoxide [SEP]  pressure (SBP) from 109 +/- 1.8 to 135 +/- 0.6 mmHg and plasma superoxide (5711 +/- 284.9 saline, 7931 +/- 392.8 U/ml dex, P < 0.001). In", "tokenized_content": [2, 10738, 3, 3772, 12, 12345, 13, 2037, 9359, 15, 19, 17, 21, 18, 28, 1942, 11477, 15, 19, 17, 20, 18, 26, 9348, 1930, 3582, 10738, 12, 4786, 3242, 15, 3]}, "items": [{"id": "p_4046", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_4047", "content": "Atorva [SEP] was significantly lower than in the dex-only group (P' < 0.05). Atorva reversed dex-induced hypertension (129 +/- 0.6 mmHg, vs. 135 +/", "tokenized_content": [2, 22973, 7302, 3, 1982, 2567, 2826, 2254, 1922, 1920, 7473, 17, 2444, 2210, 12, 58, 11, 32, 20, 18, 2914, 13, 18, 22973, 7302, 9432, 7473, 17, 2719, 5579, 12, 3]}, "items": [{"id": "p_4047", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_4048", "content": "nitrate [SEP] +/- 392.8 dex, 1187 +/- 441.2 atorva + dex, P < 0.0001). Plasma nitrate/nitrite (NOx) was decreased in dex-treated rats compared to sal", "tokenized_content": [2, 12628, 3, 15, 19, 17, 29687, 18, 28, 7473, 16, 10297, 1027, 15, 19, 17, 29904, 18, 22, 22973, 7302, 15, 7473, 16, 58, 32, 20, 18, 6060, 13, 18, 3]}, "items": [{"id": "p_4048", "content": "Nitrates [SEP] Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12628, 1036, 3, 13849, 2014, 6805, 16028, 1930, 16785, 1927, 10233, 2687, 18, 2144, 4300, 5531, 1920, 20112, 17, 6917, 18, 3]}]}
{"query": {"id": "q_4049", "content": "nitrite [SEP] 8 dex, 1187 +/- 441.2 atorva + dex, P < 0.0001). Plasma nitrate/nitrite (NOx) was decreased in dex-treated rats compared to saline-trea", "tokenized_content": [2, 15988, 3, 28, 7473, 16, 10297, 1027, 15, 19, 17, 29904, 18, 22, 22973, 7302, 15, 7473, 16, 58, 32, 20, 18, 6060, 13, 18, 3582, 12628, 19, 15988, 12, 3]}, "items": [{"id": "p_4049", "content": "Nitrites [SEP] Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all in", "score": 1, "type": null, "tokenized_content": [2, 15988, 1036, 3, 16028, 1927, 8686, 1957, 2687, 2014, 4300, 3165, 1920, 2210, 19537, 17, 18, 1920, 13849, 15988, 1036, 1927, 1920, 2601, 5890, 5265, 12, 2597, 55, 33, 6048, 13, 2032, 2136, 1922, 3]}]}
{"query": {"id": "q_4050", "content": "kainate [SEP] Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.", "tokenized_content": [2, 24714, 2010, 3, 2288, 21499, 1036, 1927, 6828, 1930, 5328, 19982, 1015, 24714, 2010, 3148, 10515, 3500, 1036, 1922, 2559, 4027, 3130, 1927, 3594, 18, 3]}, "items": [{"id": "p_4050", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_4051", "content": "pain [SEP]  kainate receptor antagonists actives in three animal models of pain.", "tokenized_content": [2, 3594, 3, 24714, 2010, 3148, 10515, 3500, 1036, 1922, 2559, 4027, 3130, 1927, 3594, 18, 3]}, "items": [{"id": "p_4051", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4052", "content": "KA [SEP] Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity ov", "tokenized_content": [2, 9580, 3, 3835, 4576, 25, 1930, 27, 16, 2288, 6828, 1930, 5328, 10362, 19982, 1015, 9580, 3148, 10515, 16, 5065, 2149, 19982, 1015, 3148, 5173, 4285, 3]}, "items": [{"id": "p_4052", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_4053", "content": "glutamate [SEP]  antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 and 8 were orally active in t", "tokenized_content": [2, 7627, 3, 10515, 16, 5065, 2149, 19982, 1015, 3148, 5173, 2338, 2303, 7627, 4086, 18, 2310, 9603, 21499, 1036, 26, 1930, 28, 1985, 12950, 3500, 1922, 62, 3]}, "items": [{"id": "p_4053", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4054", "content": "pain [SEP] ir ester prodrugs 6 and 8 were orally active in three models of pain: reversal of formalin-induced paw licking, carrageenan-induced ", "tokenized_content": [2, 3594, 3, 3166, 9603, 21499, 1036, 26, 1930, 28, 1985, 12950, 3500, 1922, 2559, 3130, 1927, 3594, 30, 12393, 1927, 12490, 17, 2719, 15329, 10247, 18046, 16, 30486, 17, 2719, 3]}, "items": [{"id": "p_4054", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4055", "content": "formalin [SEP] 6 and 8 were orally active in three models of pain: reversal of formalin-induced paw licking, carrageenan-induced thermal hyperalgesia, ", "tokenized_content": [2, 12490, 3, 26, 1930, 28, 1985, 12950, 3500, 1922, 2559, 3130, 1927, 3594, 30, 12393, 1927, 12490, 17, 2719, 15329, 10247, 18046, 16, 30486, 17, 2719, 7111, 21525, 16, 3]}, "items": [{"id": "p_4055", "content": "Formaldehyde [SEP] A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of", "score": 1, "type": null, "tokenized_content": [2, 14325, 3, 43, 3626, 6079, 18727, 4422, 5333, 2007, 6638, 2014, 9876, 24823, 1927, 22318, 18, 1922, 3331, 16, 2176, 2258, 43, 4743, 3109, 1927, 3]}]}
{"query": {"id": "q_4056", "content": "carrageenan [SEP] three models of pain: reversal of formalin-induced paw licking, carrageenan-induced thermal hyperalgesia, and capsaicin-induced mechanical ", "tokenized_content": [2, 30486, 3, 2559, 3130, 1927, 3594, 30, 12393, 1927, 12490, 17, 2719, 15329, 10247, 18046, 16, 30486, 17, 2719, 7111, 21525, 16, 1930, 19156, 17, 2719, 5821, 3]}, "items": [{"id": "p_4056", "content": "Carrageenan [SEP] A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS", "score": 1, "type": null, "tokenized_content": [2, 30486, 3, 43, 3224, 17, 6622, 5869, 2320, 5515, 1927, 26649, 18686, 2037, 2312, 17721, 18, 18095, 5777, 2032, 1920, 17187, 1023, 18901, 9136, 3176, 1036, 9635, 1034, 1957, 3]}]}
{"query": {"id": "q_4057", "content": "thermal hyperalgesia [SEP] : reversal of formalin-induced paw licking, carrageenan-induced thermal hyperalgesia, and capsaicin-induced mechanical hyperalgesia.", "tokenized_content": [2, 7111, 21525, 3, 30, 12393, 1927, 12490, 17, 2719, 15329, 10247, 18046, 16, 30486, 17, 2719, 7111, 21525, 16, 1930, 19156, 17, 2719, 5821, 21525, 18, 3]}, "items": [{"id": "p_4057", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4058", "content": "capsaicin [SEP] uced paw licking, carrageenan-induced thermal hyperalgesia, and capsaicin-induced mechanical hyperalgesia.", "tokenized_content": [2, 19156, 3, 8577, 1919, 15329, 10247, 18046, 16, 30486, 17, 2719, 7111, 21525, 16, 1930, 19156, 17, 2719, 5821, 21525, 18, 3]}, "items": [{"id": "p_4058", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_4059", "content": "mechanical hyperalgesia [SEP] carrageenan-induced thermal hyperalgesia, and capsaicin-induced mechanical hyperalgesia.", "tokenized_content": [2, 5821, 21525, 3, 30486, 17, 2719, 7111, 21525, 16, 1930, 19156, 17, 2719, 5821, 21525, 18, 3]}, "items": [{"id": "p_4059", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4060", "content": "Sirolimus [SEP] Sirolimus and mycophenolate mofetil for calcineurin-free immunosuppressio", "tokenized_content": [2, 4520, 24124, 3, 4520, 24124, 1930, 5078, 23965, 2010, 25976, 4988, 1024, 1958, 19555, 17, 3294, 27996, 3940, 3]}, "items": [{"id": "p_4060", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4061", "content": "mycophenolate mofetil [SEP] Sirolimus and mycophenolate mofetil for calcineurin-free immunosuppression in renal transplant reci", "tokenized_content": [2, 5078, 23965, 2010, 25976, 4988, 1024, 3, 4520, 24124, 1930, 5078, 23965, 2010, 25976, 4988, 1024, 1958, 19555, 17, 3294, 15858, 1922, 4604, 5192, 2090, 1033, 3]}, "items": [{"id": "p_4061", "content": "mycophenolate mofetil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5078, 23965, 2010, 25976, 4988, 1024, 3, 3]}]}
{"query": {"id": "q_4062", "content": "cyclosporine [SEP] Calcineurin inhibitors, such as cyclosporine and tacrolimus, have been available for almost 20 years. Althou", "tokenized_content": [2, 21002, 3, 19555, 4472, 16, 2427, 1966, 21002, 1930, 21801, 16, 2162, 2252, 3322, 1958, 5365, 2036, 2739, 18, 2874, 4468, 3]}, "items": [{"id": "p_4062", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4063", "content": "tacrolimus [SEP] Calcineurin inhibitors, such as cyclosporine and tacrolimus, have been available for almost 20 years. Although these drugs ", "tokenized_content": [2, 21801, 3, 19555, 4472, 16, 2427, 1966, 21002, 1930, 21801, 16, 2162, 2252, 3322, 1958, 5365, 2036, 2739, 18, 2876, 2144, 4195, 3]}, "items": [{"id": "p_4063", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4064", "content": "nephrotoxicity [SEP] t immunosuppression, they are associated with acute and chronic nephrotoxicity. Acute nephrotoxicity, which occurs in the early period after t", "tokenized_content": [2, 27880, 3, 62, 15858, 16, 2611, 2032, 2458, 1956, 3939, 1930, 3724, 27880, 18, 3939, 27880, 16, 2154, 5110, 1922, 1920, 3120, 3047, 2256, 62, 3]}, "items": [{"id": "p_4064", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4065", "content": "mycophenolate mofetil [SEP] ion increases. Two recently available immunosuppressive agents, mycophenolate mofetil and sirolimus (rapamycin), have no nephrotoxicity. The use of t", "tokenized_content": [2, 5078, 23965, 2010, 25976, 4988, 1024, 3, 4755, 4041, 18, 2288, 3998, 3322, 12910, 4820, 16, 5078, 23965, 2010, 25976, 4988, 1024, 1930, 4520, 24124, 12, 11100, 13, 16, 2162, 3]}, "items": [{"id": "p_4065", "content": "mycophenolate mofetil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5078, 23965, 2010, 25976, 4988, 1024, 3, 3]}]}
{"query": {"id": "q_4066", "content": "sirolimus [SEP] y available immunosuppressive agents, mycophenolate mofetil and sirolimus (rapamycin), have no nephrotoxicity. The use of these drugs in ", "tokenized_content": [2, 4520, 24124, 3, 67, 3322, 12910, 4820, 16, 5078, 23965, 2010, 25976, 4988, 1024, 1930, 4520, 24124, 12, 11100, 13, 16, 2162, 2239, 27880, 18, 1920, 2485, 1927, 2144, 4195, 3]}, "items": [{"id": "p_4066", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4067", "content": "rapamycin [SEP]  immunosuppressive agents, mycophenolate mofetil and sirolimus (rapamycin), have no nephrotoxicity. The use of these drugs in combination", "tokenized_content": [2, 11100, 3, 12910, 4820, 16, 5078, 23965, 2010, 25976, 4988, 1024, 1930, 4520, 24124, 12, 11100, 13, 16, 2162, 2239, 27880, 18, 1920, 2485, 1927, 2144, 4195, 1922, 3921, 3]}, "items": [{"id": "p_4067", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4068", "content": "anemia [SEP] Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumor", "tokenized_content": [2, 10679, 3, 25071, 24423, 1920, 10679, 17, 2719, 3378, 1922, 17135, 8470, 1922, 3067, 2798, 3]}, "items": [{"id": "p_4068", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_4069", "content": "cyclophosphamide [SEP] Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors.", "tokenized_content": [2, 17135, 3, 25071, 24423, 1920, 10679, 17, 2719, 3378, 1922, 17135, 8470, 1922, 3067, 3861, 18, 3]}, "items": [{"id": "p_4069", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4070", "content": "cytotoxicity [SEP] ietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors.", "tokenized_content": [2, 8470, 3, 10116, 2268, 24423, 1920, 10679, 17, 2719, 3378, 1922, 17135, 8470, 1922, 3067, 3861, 18, 3]}, "items": [{"id": "p_4070", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4071", "content": "tumors [SEP] nemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors.", "tokenized_content": [2, 3861, 3, 18264, 2126, 17, 2719, 3378, 1922, 17135, 8470, 1922, 3067, 3861, 18, 3]}, "items": [{"id": "p_4071", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4072", "content": "anemia [SEP] The aim of this study was to examine the impact of anemia prevention by recombinant human erythropoietin (rHuEPO) treatme", "tokenized_content": [2, 10679, 3, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 5020, 1920, 3829, 1927, 10679, 5455, 2007, 5752, 2616, 25071, 12, 3617, 2182, 7056, 13, 2297, 3870, 3]}, "items": [{"id": "p_4072", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_4073", "content": "cytotoxicity [SEP] n by recombinant human erythropoietin (rHuEPO) treatment on the cytotoxicity of cyclophosphamide in solid experimental tumors. Anemia was in", "tokenized_content": [2, 8470, 3, 56, 2007, 5752, 2616, 25071, 12, 3617, 2182, 7056, 13, 2311, 1990, 1920, 8470, 1927, 17135, 1922, 5358, 3599, 3861, 18, 10679, 1982, 1922, 3]}, "items": [{"id": "p_4073", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4074", "content": "cyclophosphamide [SEP]  human erythropoietin (rHuEPO) treatment on the cytotoxicity of cyclophosphamide in solid experimental tumors. Anemia was induced using a single", "tokenized_content": [2, 17135, 3, 2616, 25071, 12, 3617, 2182, 7056, 13, 2311, 1990, 1920, 8470, 1927, 17135, 1922, 5358, 3599, 3861, 18, 10679, 1982, 2719, 2193, 43, 2957, 3]}, "items": [{"id": "p_4074", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4075", "content": "tumors [SEP] t on the cytotoxicity of cyclophosphamide in solid experimental tumors. Anemia was induced using a single dose of carboplatin (50 mg/k", "tokenized_content": [2, 3861, 3, 62, 1990, 1920, 8470, 1927, 17135, 1922, 5358, 3599, 3861, 18, 10679, 1982, 2719, 2193, 43, 2957, 3253, 1927, 20072, 12, 2761, 2786, 19, 53, 3]}, "items": [{"id": "p_4075", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4076", "content": "Anemia [SEP]  cytotoxicity of cyclophosphamide in solid experimental tumors. Anemia was induced using a single dose of carboplatin (50 mg/kg i.v.) ", "tokenized_content": [2, 10679, 3, 8470, 1927, 17135, 1922, 5358, 3599, 3861, 18, 10679, 1982, 2719, 2193, 43, 2957, 3253, 1927, 20072, 12, 2761, 2786, 19, 3621, 51, 18, 64, 18, 13, 3]}, "items": [{"id": "p_4076", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_4077", "content": "carboplatin [SEP]  experimental tumors. Anemia was induced using a single dose of carboplatin (50 mg/kg i.v.) resulting in a long-lasting reduction (30%) of ", "tokenized_content": [2, 20072, 3, 3599, 3861, 18, 10679, 1982, 2719, 2193, 43, 2957, 3253, 1927, 20072, 12, 2761, 2786, 19, 3621, 51, 18, 64, 18, 13, 3864, 1922, 43, 2815, 17, 11671, 3]}, "items": [{"id": "p_4077", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_4078", "content": "sarcoma [SEP]  application. Four days after carboplatin treatment, tumors (DS-sarcoma of the rat) were implanted s.c. onto the hind food dorsum. Neit", "tokenized_content": [2, 13970, 3, 4722, 18, 3006, 3000, 2256, 20072, 2311, 16, 3861, 12, 4473, 17, 13970, 1927, 1920, 3067, 13, 1985, 10978, 61, 18, 45, 18, 6131, 1920, 8858, 3959, 6173, 3]}, "items": [{"id": "p_4078", "content": "Sarcoma [SEP] A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13970, 3, 43, 14948, 2960, 12132, 5333, 2007, 4031, 1927, 20985, 1923, 2094, 31, 2176, 1977, 5394, 3626, 6558, 18, 3]}]}
{"query": {"id": "q_4079", "content": "tumor [SEP] t on the cytotoxicity of cyclophosphamide in solid experimental tumors. Anemia was induced using a single dose of carboplatin (50 mg/", "tokenized_content": [2, 2798, 3, 62, 1990, 1920, 8470, 1927, 17135, 1922, 5358, 3599, 3861, 18, 10679, 1982, 2719, 2193, 43, 2957, 3253, 1927, 20072, 12, 2761, 2786, 19, 3]}, "items": [{"id": "p_4079", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4080", "content": "oxygen [SEP]  increases the sensitivity, probably as a result of an improved oxygen supply to tumor tissue.", "tokenized_content": [2, 4612, 3, 4041, 1920, 3802, 16, 6226, 1966, 43, 3211, 1927, 1925, 4305, 4612, 9042, 1942, 2798, 2960, 18, 3]}, "items": [{"id": "p_4080", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_4081", "content": "lidocaine [SEP] The role of nitrergic system in lidocaine-induced convulsion in the mouse.", "tokenized_content": [2, 19567, 3, 1920, 2770, 1927, 8214, 5237, 2433, 1922, 19567, 17, 2719, 4772, 12138, 1922, 1920, 3321, 18, 3]}, "items": [{"id": "p_4081", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_4082", "content": "convulsion [SEP] The role of nitrergic system in lidocaine-induced convulsion in the mouse.", "tokenized_content": [2, 4772, 12138, 3, 1920, 2770, 1927, 8214, 5237, 2433, 1922, 19567, 17, 2719, 4772, 12138, 1922, 1920, 3321, 18, 3]}, "items": [{"id": "p_4082", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4083", "content": "N-nitro-L-arginine-methyl ester [SEP] The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine,", "tokenized_content": [2, 56, 17, 8686, 17, 54, 17, 9732, 17, 4963, 9603, 3, 1920, 2564, 1927, 56, 17, 8686, 17, 54, 17, 9732, 17, 4963, 9603, 12, 54, 17, 9533, 13, 43, 3]}, "items": [{"id": "p_4083", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_4084", "content": "L-NAME [SEP] The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine, a NO pr", "tokenized_content": [2, 54, 17, 9533, 3, 1920, 2564, 1927, 56, 17, 8686, 17, 54, 17, 9732, 17, 4963, 9603, 12, 54, 17, 9533, 13, 43, 10233, 7491, 12, 2239, 13, 8921, 4106, 3]}, "items": [{"id": "p_4084", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_4085", "content": "nitric oxide [SEP] The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine, a NO precursor, were in", "tokenized_content": [2, 10233, 7491, 3, 1920, 2564, 1927, 56, 17, 8686, 17, 54, 17, 9732, 17, 4963, 9603, 12, 54, 17, 9533, 13, 43, 10233, 7491, 12, 2239, 13, 8921, 4106, 1930, 3]}, "items": [{"id": "p_4085", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_4086", "content": "NO [SEP] cts of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine, a NO precursor, were invest", "tokenized_content": [2, 2239, 3, 15359, 1927, 56, 17, 8686, 17, 54, 17, 9732, 17, 4963, 9603, 12, 54, 17, 9533, 13, 43, 10233, 7491, 12, 2239, 13, 8921, 4106, 1930, 54, 17, 3]}, "items": [{"id": "p_4086", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_4087", "content": "L-arginine [SEP] The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor an", "tokenized_content": [2, 54, 17, 9732, 3, 1920, 2564, 1927, 56, 17, 8686, 17, 54, 17, 9732, 17, 4963, 9603, 12, 54, 17, 9533, 13, 43, 10233, 7491, 12, 2239, 13, 8921, 4106, 3]}, "items": [{"id": "p_4087", "content": "Arginine [SEP] An essential amino acid that is physiologically active in the L-form.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9732, 3, 1925, 4415, 3835, 2687, 1988, 1977, 15899, 3500, 1922, 1920, 54, 17, 2386, 18, 3]}]}
{"query": {"id": "q_4088", "content": "lidocaine [SEP]  inhibitor and L-arginine, a NO precursor, were investigated on lidocaine-induced convulsions. In the first experiment, four groups of mi", "tokenized_content": [2, 19567, 3, 4106, 1930, 54, 17, 9732, 16, 43, 2239, 7897, 16, 1985, 3845, 1990, 19567, 17, 2719, 4772, 19389, 18, 1922, 1920, 2561, 3859, 16, 3006, 2671, 1927, 6519, 3]}, "items": [{"id": "p_4088", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_4089", "content": "convulsions [SEP] rginine, a NO precursor, were investigated on lidocaine-induced convulsions. In the first experiment, four groups of mice received physiolo", "tokenized_content": [2, 4772, 19389, 3, 9372, 15020, 1021, 16, 43, 2239, 7897, 16, 1985, 3845, 1990, 19567, 17, 2719, 4772, 19389, 18, 1922, 1920, 2561, 3859, 16, 3006, 2671, 1927, 2518, 4004, 3]}, "items": [{"id": "p_4089", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4090", "content": "diazepam [SEP] 9%), L-arginine (300 mg/kg, i.p.), L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg), respectively. Thirty minutes after these injections,", "tokenized_content": [2, 26079, 3, 29, 9, 13, 16, 54, 17, 9732, 12, 5255, 2786, 19, 3621, 16, 51, 18, 58, 18, 13, 16, 54, 17, 9533, 12, 2813, 2786, 19, 3621, 16, 3]}, "items": [{"id": "p_4090", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_4091", "content": "metoprolol [SEP] Effect of intravenous metoprolol or intravenous metoprolol plus glucagon on dobutamine-induced m", "tokenized_content": [2, 2130, 17712, 1945, 3, 2495, 1927, 7307, 2130, 17712, 1945, 2014, 7307, 2130, 17712, 1945, 5390, 16167, 1990, 2608, 16119, 3812, 17, 2719, 55, 3]}, "items": [{"id": "p_4091", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_4092", "content": "dobutamine [SEP] travenous metoprolol or intravenous metoprolol plus glucagon on dobutamine-induced myocardial ischemia.", "tokenized_content": [2, 2608, 16119, 3812, 3, 20636, 5200, 2130, 17712, 1945, 2014, 7307, 2130, 17712, 1945, 5390, 16167, 1990, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 3]}, "items": [{"id": "p_4092", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_4093", "content": "myocardial ischemia [SEP] l or intravenous metoprolol plus glucagon on dobutamine-induced myocardial ischemia.", "tokenized_content": [2, 6497, 7716, 3, 54, 2014, 7307, 2130, 17712, 1945, 5390, 16167, 1990, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 3]}, "items": [{"id": "p_4093", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_4094", "content": "metoprolol [SEP] STUDY OBJECTIVE: To determine the effect of metoprolol on dobutamine stress testing with technetium-99m sestamibi sing", "tokenized_content": [2, 2130, 17712, 1945, 3, 2161, 4470, 30, 1942, 3415, 1920, 2495, 1927, 2130, 17712, 1945, 1990, 2608, 16119, 3812, 3071, 4213, 1956, 2913, 4988, 1989, 17, 17660, 9924, 3857, 7395, 3]}, "items": [{"id": "p_4094", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_4095", "content": "dobutamine [SEP] STUDY OBJECTIVE: To determine the effect of metoprolol on dobutamine stress testing with technetium-99m sestamibi single-photon emis", "tokenized_content": [2, 2608, 16119, 3812, 3, 2161, 4470, 30, 1942, 3415, 1920, 2495, 1927, 2130, 17712, 1945, 1990, 2608, 16119, 3812, 3071, 4213, 1956, 2913, 4988, 1989, 17, 17660, 9924, 3857, 7395, 3]}, "items": [{"id": "p_4095", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_4096", "content": "technetium-99m sestamibi [SEP] mine the effect of metoprolol on dobutamine stress testing with technetium-99m sestamibi single-photon emission computed tomography imaging and ST-segme", "tokenized_content": [2, 2913, 4988, 1989, 17, 17660, 9924, 3857, 7395, 3821, 3, 24165, 1920, 2495, 1927, 2130, 17712, 1945, 1990, 2608, 16119, 3812, 3071, 4213, 1956, 2913, 4988, 1989, 17, 17660, 9924, 3]}, "items": [{"id": "p_4096", "content": "Technetium Tc 99m Sestamibi [SEP] A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2913, 4988, 1989, 5283, 17660, 9924, 3857, 7395, 3821, 3, 43, 2913, 4988, 1989, 3755, 5899, 2251, 1942, 3157, 2877, 17, 17704, 4435, 2960, 2409, 43, 4003, 8926, 18, 3]}]}
{"query": {"id": "q_4097", "content": "Metoprolol [SEP]  visits to receive metoprolol or metoprolol plus glucagon 1 mg. Metoprolol was dosed to achieve a resting predobutamine heart rate below 6", "tokenized_content": [2, 2130, 17712, 1945, 3, 7870, 1942, 7130, 2130, 17712, 1945, 2014, 2130, 17712, 1945, 5390, 16167, 21, 2786, 18, 2130, 17712, 1945, 1982, 25922, 1942, 6230, 43, 8513, 2598, 14253, 3]}, "items": [{"id": "p_4097", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_4098", "content": "myocardial ischemia [SEP] stress testing, metoprolol attenuates or eliminates evidence of myocardial ischemia. Glucagon 1 mg, although somewhat effective, does not correct t", "tokenized_content": [2, 6497, 7716, 3, 3071, 4213, 16, 2130, 17712, 1945, 18260, 2014, 22400, 3095, 1927, 6497, 7716, 18, 16167, 21, 2786, 16, 2876, 9786, 3655, 16, 3731, 2084, 5550, 62, 3]}, "items": [{"id": "p_4098", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_4099", "content": "Prednisolone [SEP] Prednisolone-induced muscle dysfunction is caused more by atrophy than by al", "tokenized_content": [2, 22025, 3, 22025, 17, 2719, 3760, 5273, 1977, 4189, 2253, 2007, 10260, 2254, 2007, 1969, 3]}, "items": [{"id": "p_4099", "content": "Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin", "score": 1, "type": null, "tokenized_content": [2, 22025, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 1920, 14610, 18, 2176, 1977, 1920, 2838, 1927, 6259, 1958, 2136, 2961, 1922, 2154, 10276, 3]}]}
{"query": {"id": "q_4100", "content": "muscle dysfunction [SEP] Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine recepto", "tokenized_content": [2, 3760, 5273, 3, 22025, 17, 2719, 3760, 5273, 1977, 4189, 2253, 2007, 10260, 2254, 2007, 5520, 14561, 2793, 4575, 3]}, "items": [{"id": "p_4100", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_4101", "content": "atrophy [SEP] Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression.", "tokenized_content": [2, 10260, 3, 22025, 17, 2719, 3760, 5273, 1977, 4189, 2253, 2007, 10260, 2254, 2007, 5520, 14561, 3148, 2294, 18, 3]}, "items": [{"id": "p_4101", "content": "Atrophy [SEP] Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as ", "score": 1, "type": null, "tokenized_content": [2, 10260, 3, 3714, 1922, 1920, 3081, 1927, 43, 2024, 16, 2960, 16, 3090, 16, 2014, 3137, 7393, 16, 2458, 1956, 43, 5386, 1927, 6598, 2961, 2427, 1966, 3]}]}
{"query": {"id": "q_4102", "content": "acetylcholine [SEP] ed muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression.", "tokenized_content": [2, 14561, 3, 3347, 3760, 5273, 1977, 4189, 2253, 2007, 10260, 2254, 2007, 5520, 14561, 3148, 2294, 18, 3]}, "items": [{"id": "p_4102", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_4103", "content": "prednisolone [SEP] ood. We investigated the effects of moderate and large doses of prednisolone on muscle function and pharmacology, and their relationship to ", "tokenized_content": [2, 22025, 3, 57, 1986, 18, 2038, 3845, 1920, 2564, 1927, 5086, 1930, 3103, 5312, 1927, 22025, 1990, 3760, 2347, 1930, 18374, 16, 1930, 2310, 3303, 1942, 3]}, "items": [{"id": "p_4103", "content": "Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin", "score": 1, "type": null, "tokenized_content": [2, 22025, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 1920, 14610, 18, 2176, 1977, 1920, 2838, 1927, 6259, 1958, 2136, 2961, 1922, 2154, 10276, 3]}]}
{"query": {"id": "q_4104", "content": "acetylcholine [SEP] rmacology, and their relationship to changes in muscle size and acetylcholine receptor (AChR) expression. With institutional approval, 35 Spr", "tokenized_content": [2, 14561, 3, 10625, 20682, 22284, 1012, 16, 1930, 2310, 3303, 1942, 2840, 1922, 3760, 3081, 1930, 14561, 3148, 12, 28216, 13, 2294, 18, 1956, 6540, 8382, 16, 3259, 6039, 3]}, "items": [{"id": "p_4104", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_4105", "content": "tetanic [SEP] ys (FR group). On Day 8, the nerve-evoked peak twitch tensions, tetanic tensions, and fatigability, and the dose-response curves of d-t", "tokenized_content": [2, 9717, 19510, 3, 24018, 12, 2415, 2210, 13, 18, 1990, 3007, 28, 16, 1920, 5507, 17, 8782, 3833, 21596, 10146, 1036, 16, 9717, 19510, 10146, 1036, 16, 1930, 8393, 2550, 3]}, "items": [{"id": "p_4105", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_4106", "content": "d-tubocurarine [SEP] nic tensions, and fatigability, and the dose-response curves of d-tubocurarine in the tibialis cranialis muscle were measured in vivo and rela", "tokenized_content": [2, 46, 17, 3710, 1994, 9280, 5773, 3, 11188, 10146, 1036, 16, 1930, 8393, 2550, 16, 1930, 1920, 3253, 17, 2644, 6223, 1927, 46, 17, 3710, 1994, 9280, 5773, 1922, 1920, 3]}, "items": [{"id": "p_4106", "content": "Tubocurarine [SEP] A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3710, 1994, 9280, 5773, 3, 43, 15829, 14580, 1930, 3500, 24364, 1922, 3580, 2768, 31, 4496, 2454, 29951, 1927, 19409, 2116, 26016, 5376, 1021, 18, 3]}]}
{"query": {"id": "q_4107", "content": "neuromuscular dysfunction [SEP] th muscle mass or AChR expression. Our results suggest that the neuromuscular dysfunction after prednisolone is dose-dependent, and derives primarily fro", "tokenized_content": [2, 15829, 5273, 3, 1913, 3760, 3411, 2014, 28216, 2294, 18, 2342, 2274, 3220, 1988, 1920, 15829, 5273, 2256, 22025, 1977, 3253, 17, 3100, 16, 1930, 28322, 5985, 7542, 3]}, "items": [{"id": "p_4107", "content": "Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif", "score": 1, "type": null, "tokenized_content": [2, 15829, 3902, 3, 43, 3335, 2576, 17527, 2826, 4842, 7428, 2573, 31, 5009, 7580, 2433, 3902, 31, 1930, 4908, 12330, 3902, 18, 6747, 3]}]}
{"query": {"id": "q_4108", "content": "muscle atrophy [SEP] fter prednisolone is dose-dependent, and derives primarily from muscle atrophy and derives less so from changes in AChR expression. IMPLICATIO", "tokenized_content": [2, 3760, 10260, 3, 8916, 1915, 22025, 1977, 3253, 17, 3100, 16, 1930, 28322, 5985, 2037, 3760, 10260, 1930, 28322, 2941, 2577, 2037, 2840, 1922, 28216, 2294, 18, 6313, 6102, 1914, 3]}, "items": [{"id": "p_4108", "content": "Muscular Atrophy [SEP] Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, pr", "score": 1, "type": null, "tokenized_content": [2, 12330, 10260, 3, 3135, 9538, 1922, 3081, 1930, 2529, 1927, 3760, 6989, 6966, 1956, 6619, 16, 3378, 1922, 2877, 9042, 16, 2014, 2894, 16704, 16, 2033, 3]}]}
{"query": {"id": "q_4109", "content": "diltiazem [SEP] Rapid reversal of life-threatening diltiazem-induced tetany with calcium chloride.", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 4052, 12393, 1927, 3308, 17, 13281, 4333, 11574, 6931, 1035, 17, 2719, 9717, 5323, 1956, 5016, 9140, 18, 3]}, "items": [{"id": "p_4109", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_4110", "content": "tetany [SEP] Rapid reversal of life-threatening diltiazem-induced tetany with calcium chloride.", "tokenized_content": [2, 9717, 5323, 3, 4052, 12393, 1927, 3308, 17, 13281, 4333, 11574, 6931, 1035, 17, 2719, 9717, 5323, 1956, 5016, 9140, 18, 3]}, "items": [{"id": "p_4110", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_4111", "content": "calcium chloride [SEP] apid reversal of life-threatening diltiazem-induced tetany with calcium chloride.", "tokenized_content": [2, 5016, 9140, 3, 20655, 1007, 12393, 1927, 3308, 17, 13281, 4333, 11574, 6931, 1035, 17, 2719, 9717, 5323, 1956, 5016, 9140, 18, 3]}, "items": [{"id": "p_4111", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_4112", "content": "tetany [SEP] We describe a patient who developed tetany with sudden respiratory arrest after the infusion of intravenou", "tokenized_content": [2, 9717, 5323, 3, 2038, 5993, 43, 2774, 2746, 3530, 9717, 5323, 1956, 12446, 5481, 8048, 2256, 1920, 7386, 1927, 6306, 19824, 1032, 3]}, "items": [{"id": "p_4112", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_4113", "content": "respiratory arrest [SEP] We describe a patient who developed tetany with sudden respiratory arrest after the infusion of intravenous diltiazem. The administration", "tokenized_content": [2, 5481, 8048, 3, 2038, 5993, 43, 2774, 2746, 3530, 9717, 5323, 1956, 12446, 5481, 8048, 2256, 1920, 7386, 1927, 7307, 4333, 11574, 6931, 1035, 18, 1920, 4183, 3]}, "items": [{"id": "p_4113", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4114", "content": "diltiazem [SEP] ith sudden respiratory arrest after the infusion of intravenous diltiazem. The administration of calcium chloride rapidly resolved the pa", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 24737, 12446, 5481, 8048, 2256, 1920, 7386, 1927, 7307, 4333, 11574, 6931, 1035, 18, 1920, 4183, 1927, 5016, 9140, 6221, 8397, 1920, 3838, 3]}, "items": [{"id": "p_4114", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_4115", "content": "calcium chloride [SEP] er the infusion of intravenous diltiazem. The administration of calcium chloride rapidly resolved the patient's tetany with prompt recovery of r", "tokenized_content": [2, 5016, 9140, 3, 2668, 1920, 7386, 1927, 7307, 4333, 11574, 6931, 1035, 18, 1920, 4183, 1927, 5016, 9140, 6221, 8397, 1920, 2774, 11, 61, 9717, 5323, 1956, 14393, 5241, 1927, 3]}, "items": [{"id": "p_4115", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_4116", "content": "aneurysmal subarachnoid hemorrhage [SEP] teroidal anti-inflammatory drugs on hemostasis in patients with aneurysmal subarachnoid hemorrhage.", "tokenized_content": [2, 13373, 1923, 23795, 10489, 3, 6005, 8814, 2246, 17, 3769, 4195, 1990, 23963, 1922, 2132, 1956, 13373, 1923, 23795, 10489, 18, 3]}, "items": [{"id": "p_4116", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_4117", "content": "aneurysmal subarachnoid hemorrhage [SEP]  undergoing intracranial surgery is under debate. Patients with aneurysmal subarachnoid hemorrhage (SAH) were randomized to receive either ketoprofen, 100 mg, thr", "tokenized_content": [2, 13373, 1923, 23795, 10489, 3, 7258, 12179, 3782, 1977, 2441, 14116, 18, 2132, 1956, 13373, 1923, 23795, 10489, 12, 11738, 13, 1985, 5542, 1942, 7130, 3108, 21471, 22945, 16, 2813, 3]}, "items": [{"id": "p_4117", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_4118", "content": "SAH [SEP] under debate. Patients with aneurysmal subarachnoid hemorrhage (SAH) were randomized to receive either ketoprofen, 100 mg, three ti", "tokenized_content": [2, 11738, 3, 2441, 14116, 18, 2132, 1956, 13373, 1923, 23795, 10489, 12, 11738, 13, 1985, 5542, 1942, 7130, 3108, 21471, 22945, 16, 2813, 2786, 16, 2559, 8685, 3]}, "items": [{"id": "p_4118", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_4119", "content": "ketoprofen [SEP] subarachnoid hemorrhage (SAH) were randomized to receive either ketoprofen, 100 mg, three times a day (ketoprofen group, n = 9) or a weak ", "tokenized_content": [2, 21471, 22945, 3, 23795, 10489, 12, 11738, 13, 1985, 5542, 1942, 7130, 3108, 21471, 22945, 16, 2813, 2786, 16, 2559, 3586, 43, 3007, 12, 21471, 22945, 2210, 16, 56, 33, 3]}, "items": [{"id": "p_4119", "content": "Ketoprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarth", "score": 1, "type": null, "tokenized_content": [2, 21471, 22945, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 13053, 8884, 1930, 14108, 1963, 3]}]}
{"query": {"id": "q_4120", "content": "acetaminophen [SEP] g, three times a day (ketoprofen group, n = 9) or a weak NSAID, acetaminophen, 1 g, three times a day (acetaminophen group, n = 9) starting i", "tokenized_content": [2, 23311, 3, 49, 16, 2559, 3586, 43, 3007, 12, 21471, 22945, 2210, 16, 56, 33, 29, 13, 2014, 43, 5015, 24194, 16, 23311, 16, 21, 49, 16, 2559, 3586, 43, 3]}, "items": [{"id": "p_4120", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4121", "content": "aneurysmal [SEP]  undergoing intracranial surgery is under debate. Patients with aneurysmal subarachnoid hemorrhage (SAH) were randomized to receive either", "tokenized_content": [2, 13373, 1923, 3, 7258, 12179, 3782, 1977, 2441, 14116, 18, 2132, 1956, 13373, 1923, 23795, 10489, 12, 11738, 13, 1985, 5542, 1942, 7130, 3108, 3]}, "items": [{"id": "p_4121", "content": "Aneurysm, Ruptured [SEP] The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger ", "score": 1, "type": null, "tokenized_content": [2, 13373, 16, 24390, 3, 1920, 12650, 1941, 2014, 27823, 1927, 1920, 24214, 4821, 1927, 1920, 13373, 1923, 10791, 16, 5394, 3656, 12666, 1919, 2007, 12446, 15473, 3594, 18, 1920, 4733, 15378, 3]}]}
{"query": {"id": "q_4122", "content": "platelet aggregation [SEP]  on the first, third, and fifth postoperative mornings. Maximal platelet aggregation induced by 6 microM of adenosine diphosphate decreased after ad", "tokenized_content": [2, 7163, 7883, 3, 1990, 1920, 2561, 16, 4563, 16, 1930, 12052, 5924, 12661, 1036, 18, 7275, 7163, 7883, 2719, 2007, 26, 7709, 1927, 10125, 23266, 3261, 2256, 2041, 3]}, "items": [{"id": "p_4122", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_4123", "content": "adenosine diphosphate [SEP] e mornings. Maximal platelet aggregation induced by 6 microM of adenosine diphosphate decreased after administration of ketoprofen. Aggregation was l", "tokenized_content": [2, 10125, 23266, 3, 47, 12661, 1036, 18, 7275, 7163, 7883, 2719, 2007, 26, 7709, 1927, 10125, 23266, 3261, 2256, 4183, 1927, 21471, 22945, 18, 7883, 1982, 54, 3]}, "items": [{"id": "p_4123", "content": "Adenosine Diphosphate [SEP] Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at ", "score": 1, "type": null, "tokenized_content": [2, 10125, 23266, 3, 10125, 25, 11, 17, 12, 5083, 8535, 2432, 23266, 13, 18, 1925, 15643, 5489, 3165, 2288, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 2019, 3]}]}
{"query": {"id": "q_4124", "content": "hematoma [SEP]  in the ketoprofen group developed a postoperative intracranial hematoma. Coagulation (prothrombin time [PT], activated partial thrombop", "tokenized_content": [2, 18984, 3, 1922, 1920, 21471, 22945, 2210, 3530, 43, 5924, 12179, 18984, 18, 12441, 12, 23976, 2367, 37, 4401, 39, 16, 4128, 5740, 16379, 1034, 3]}, "items": [{"id": "p_4124", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_4125", "content": "Ketoprofen [SEP] tithrombin III [AT III]) was comparable between the two groups. Ketoprofen but not acetaminophen impaired platelet function in patients wi", "tokenized_content": [2, 21471, 22945, 3, 7090, 6570, 10123, 1921, 4337, 37, 2019, 4337, 39, 13, 1982, 5596, 2192, 1920, 2288, 2671, 18, 21471, 22945, 2308, 2084, 23311, 5761, 7163, 2347, 1922, 2132, 3]}, "items": [{"id": "p_4125", "content": "Ketoprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarth", "score": 1, "type": null, "tokenized_content": [2, 21471, 22945, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 13053, 8884, 1930, 14108, 1963, 3]}]}
{"query": {"id": "q_4126", "content": "artery aneurysms [SEP] ents with SAH. If ketoprofen is used before surgery on cerebral artery aneurysms, it may pose an additional risk factor for hemorrhage.", "tokenized_content": [2, 5511, 16673, 3, 8496, 1036, 1956, 11738, 18, 2647, 21471, 22945, 1977, 2251, 3119, 3782, 1990, 6329, 5511, 16673, 16, 2176, 2278, 15271, 1925, 3281, 2565, 2991, 1958, 10489, 18, 3]}, "items": [{"id": "p_4126", "content": "Intracranial Aneurysm [SEP] Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch", "score": 1, "type": null, "tokenized_content": [2, 12179, 13373, 3, 4552, 2397, 7056, 16908, 2029, 1922, 1920, 4821, 1927, 12179, 2877, 7208, 18, 2501, 3059, 2032, 1920, 12988, 2168, 12, 28195, 13, 16673, 4810, 2019, 6089, 3]}]}
{"query": {"id": "q_4127", "content": "hemorrhage [SEP]  surgery is under debate. Patients with aneurysmal subarachnoid hemorrhage (SAH) were randomized to receive either ketoprofen, 100 mg, thr", "tokenized_content": [2, 10489, 3, 3782, 1977, 2441, 14116, 18, 2132, 1956, 13373, 1923, 23795, 10489, 12, 11738, 13, 1985, 5542, 1942, 7130, 3108, 21471, 22945, 16, 2813, 2786, 16, 8481, 3]}, "items": [{"id": "p_4127", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4128", "content": "methylprednisolone [SEP] Value of methylprednisolone in prevention of the arthralgia-myalgia syndrome associated wit", "tokenized_content": [2, 30087, 3, 3113, 1927, 30087, 1922, 5455, 1927, 1920, 9273, 7317, 11966, 17, 3057, 20394, 2126, 4741, 2458, 16086, 3]}, "items": [{"id": "p_4128", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_4129", "content": "arthralgia [SEP] Value of methylprednisolone in prevention of the arthralgia-myalgia syndrome associated with the total dose infusion of iro", "tokenized_content": [2, 9273, 7317, 11966, 3, 3113, 1927, 30087, 1922, 5455, 1927, 1920, 9273, 7317, 11966, 17, 3057, 20394, 2126, 4741, 2458, 1956, 1920, 2698, 3253, 7386, 1927, 3166, 1037, 3]}, "items": [{"id": "p_4129", "content": "Arthralgia [SEP] Pain in the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 7317, 11966, 3, 3594, 1922, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_4130", "content": "myalgia [SEP] Value of methylprednisolone in prevention of the arthralgia-myalgia syndrome associated with the total dose infusion of iron dextra", "tokenized_content": [2, 3057, 20394, 2126, 3, 3113, 1927, 30087, 1922, 5455, 1927, 1920, 9273, 7317, 11966, 17, 3057, 20394, 2126, 4741, 2458, 1956, 1920, 2698, 3253, 7386, 1927, 5680, 20256, 5524, 3]}, "items": [{"id": "p_4130", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_4131", "content": "iron dextran [SEP] gia-myalgia syndrome associated with the total dose infusion of iron dextran: a double blind randomized trial.", "tokenized_content": [2, 5680, 15195, 3, 7217, 1019, 17, 3057, 20394, 2126, 4741, 2458, 1956, 1920, 2698, 3253, 7386, 1927, 5680, 15195, 30, 43, 4825, 7109, 5542, 3046, 18, 3]}, "items": [{"id": "p_4131", "content": "Iron-Dextran Complex [SEP] A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is ", "score": 1, "type": null, "tokenized_content": [2, 5680, 17, 15195, 2796, 3, 43, 2796, 1927, 20247, 20004, 8535, 18068, 3695, 1956, 15195, 1036, 1927, 13576, 1942, 11851, 1008, 15880, 5405, 1036, 1922, 43, 24855, 3331, 3165, 2761, 2786, 19, 2646, 1927, 5680, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_4132", "content": "iron dextran [SEP] The safety and efficacy of total dose infusion (TDI) of iron dextran has been well documented. In 40% of treated patients, an arthra", "tokenized_content": [2, 5680, 15195, 3, 1920, 5407, 1930, 4348, 1927, 2698, 3253, 7386, 12, 6888, 1033, 13, 1927, 5680, 15195, 2258, 2252, 2486, 6974, 18, 1922, 3040, 9, 1927, 2868, 2132, 16, 3]}, "items": [{"id": "p_4132", "content": "Iron-Dextran Complex [SEP] A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is ", "score": 1, "type": null, "tokenized_content": [2, 5680, 17, 15195, 2796, 3, 43, 2796, 1927, 20247, 20004, 8535, 18068, 3695, 1956, 15195, 1036, 1927, 13576, 1942, 11851, 1008, 15880, 5405, 1036, 1922, 43, 24855, 3331, 3165, 2761, 2786, 19, 2646, 1927, 5680, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_4133", "content": "arthralgia [SEP] extran has been well documented. In 40% of treated patients, an arthralgia-myalgia syndrome develops. The purpose of this randomized, doub", "tokenized_content": [2, 9273, 7317, 11966, 3, 8324, 1022, 2258, 2252, 2486, 6974, 18, 1922, 3040, 9, 1927, 2868, 2132, 16, 1925, 9273, 7317, 11966, 17, 3057, 20394, 2126, 4741, 15143, 18, 1920, 3]}, "items": [{"id": "p_4133", "content": "Arthralgia [SEP] Pain in the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 7317, 11966, 3, 3594, 1922, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_4134", "content": "myalgia [SEP] been well documented. In 40% of treated patients, an arthralgia-myalgia syndrome develops. The purpose of this randomized, double-blind", "tokenized_content": [2, 3057, 20394, 2126, 3, 2252, 2486, 6974, 18, 1922, 3040, 9, 1927, 2868, 2132, 16, 1925, 9273, 7317, 11966, 17, 3057, 20394, 2126, 4741, 15143, 18, 1920, 5120, 1927, 2052, 3]}, "items": [{"id": "p_4134", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_4135", "content": "methylprednisolone [SEP] was to investigate whether intravenous (i.v.) administration of methylprednisolone (MP) prevents this complication. Sixty-five patients, 34 women ", "tokenized_content": [2, 30087, 3, 1982, 1942, 4482, 3053, 7307, 12, 51, 18, 64, 18, 13, 4183, 1927, 30087, 12, 5438, 13, 10299, 2052, 9388, 18, 14063, 17, 3628, 2132, 16, 3540, 3089, 3]}, "items": [{"id": "p_4135", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_4136", "content": "MP [SEP] hether intravenous (i.v.) administration of methylprednisolone (MP) prevents this complication. Sixty-five patients, 34 women and ", "tokenized_content": [2, 5438, 3, 21997, 2380, 7307, 12, 51, 18, 64, 18, 13, 4183, 1927, 30087, 12, 5438, 13, 10299, 2052, 9388, 18, 14063, 17, 3628, 2132, 16, 3540, 3089, 1930, 3]}, "items": [{"id": "p_4136", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_4137", "content": "vincristine [SEP] Long-term effects of vincristine on the peripheral nervous system.", "tokenized_content": [2, 25446, 3, 2815, 17, 2576, 2564, 1927, 25446, 1990, 1920, 5009, 7580, 2433, 18, 3]}, "items": [{"id": "p_4137", "content": "Vincristine [SEP] Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)\n    ", "score": 1, "type": null, "tokenized_content": [2, 25446, 3, 11775, 29951, 3937, 2037, 24198, 1019, 13679, 1019, 18, 12, 14556, 16, 2513, 1963, 3347, 18, 13, 3]}]}
{"query": {"id": "q_4138", "content": "Non-Hodgkin's Lymphoma [SEP] Forty patients with Non-Hodgkin's Lymphoma treated with vincristine between 1984 and 1990 (cumulative dose", "tokenized_content": [2, 2447, 17, 17447, 11, 61, 8636, 3, 11270, 2132, 1956, 2447, 17, 17447, 11, 61, 8636, 2868, 1956, 25446, 2192, 12812, 1930, 7804, 12, 8274, 3253, 3]}, "items": [{"id": "p_4138", "content": "Lymphoma, Non-Hodgkin [SEP] Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to", "score": 1, "type": null, "tokenized_content": [2, 8636, 16, 2447, 17, 17447, 3, 2967, 1927, 43, 2210, 1927, 6558, 3861, 1927, 11751, 2960, 1988, 2129, 2037, 17447, 2573, 16, 3301, 2253, 8538, 1956, 5633, 1942, 3]}]}
{"query": {"id": "q_4139", "content": "vincristine [SEP] Forty patients with Non-Hodgkin's Lymphoma treated with vincristine between 1984 and 1990 (cumulative dose 12 mg in 18-24 weeks) we", "tokenized_content": [2, 25446, 3, 11270, 2132, 1956, 2447, 17, 17447, 11, 61, 8636, 2868, 1956, 25446, 2192, 12812, 1930, 7804, 12, 8274, 3253, 2369, 2786, 1922, 2654, 17, 2686, 3625, 13, 2038, 3]}, "items": [{"id": "p_4139", "content": "Vincristine [SEP] Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)\n    ", "score": 1, "type": null, "tokenized_content": [2, 25446, 3, 11775, 29951, 3937, 2037, 24198, 1019, 13679, 1019, 18, 12, 14556, 16, 2513, 1963, 3347, 18, 13, 3]}]}
{"query": {"id": "q_4140", "content": "neuropathic symptoms [SEP]  nervous system. The patients were interviewed with emphasis on neuropathic symptoms. Physical and quantitative sensory examination with determinati", "tokenized_content": [2, 16591, 3601, 3, 7580, 2433, 18, 1920, 2132, 1985, 14213, 1956, 12286, 1990, 16591, 3601, 18, 3841, 1930, 4794, 6893, 4981, 1956, 8894, 1968, 3]}, "items": [{"id": "p_4140", "content": "Sensation Disorders [SEP] Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of ", "score": 1, "type": null, "tokenized_content": [2, 15826, 4414, 3, 4414, 1927, 1920, 5180, 7534, 1036, 12, 51, 18, 47, 18, 16, 9266, 31, 8512, 31, 13891, 31, 1930, 2426, 1992, 13, 2014, 17562, 2433, 12, 51, 18, 47, 18, 16, 15604, 4178, 1927, 3]}]}
{"query": {"id": "q_4141", "content": "neuropathy [SEP] ned vincristine dose schedule signs and symptoms of vincristine neuropathy are reversible for a great deal and prognosis is fairly good.", "tokenized_content": [2, 13177, 3, 2069, 1007, 25446, 3253, 11660, 6879, 1930, 3601, 1927, 25446, 13177, 2032, 10743, 1958, 43, 4733, 10370, 1930, 6573, 1977, 14898, 4227, 18, 3]}, "items": [{"id": "p_4141", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4142", "content": "polymyositis [SEP] A case of polymyositis in a patient with primary biliary cirrhosis treated with D-peni", "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 43, 3087, 1927, 3491, 25749, 12924, 3600, 1922, 43, 2774, 1956, 3065, 13210, 11260, 2868, 1956, 46, 17, 4959, 1033, 3]}, "items": [{"id": "p_4142", "content": "Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi", "score": 1, "type": null, "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3902, 4378, 2007, 4531, 5884, 3137, 7848, 18, 2052, 2278, 4704, 1966, 1925, 3939, 2014, 3724, 2625, 2458, 11980, 3]}]}
{"query": {"id": "q_4143", "content": "primary biliary cirrhosis [SEP] A case of polymyositis in a patient with primary biliary cirrhosis treated with D-penicillamine.", "tokenized_content": [2, 3065, 13210, 11260, 3, 43, 3087, 1927, 3491, 25749, 12924, 3600, 1922, 43, 2774, 1956, 3065, 13210, 11260, 2868, 1956, 46, 17, 25142, 3812, 18, 3]}, "items": [{"id": "p_4143", "content": "Liver Cirrhosis, Biliary [SEP] FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts ", "score": 1, "type": null, "tokenized_content": [2, 3568, 11260, 16, 13210, 3, 6769, 1927, 1920, 6095, 15214, 2810, 1942, 10849, 1927, 9619, 3426, 12, 30086, 13, 1922, 1920, 22323, 2014, 29086, 9619, 19277, 3]}]}
{"query": {"id": "q_4144", "content": "D-penicillamine [SEP] ositis in a patient with primary biliary cirrhosis treated with D-penicillamine.", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 3125, 3678, 1922, 43, 2774, 1956, 3065, 13210, 11260, 2868, 1956, 46, 17, 25142, 3812, 18, 3]}, "items": [{"id": "p_4144", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_4145", "content": "D-penicillamine [SEP] Although D-penicillamine has been used for many rheumatologic diseases, toxicity limits ", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 2876, 46, 17, 25142, 3812, 2258, 2252, 2251, 1958, 3086, 10939, 4467, 3902, 16, 5532, 8183, 3]}, "items": [{"id": "p_4145", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_4146", "content": "rheumatologic diseases [SEP] Although D-penicillamine has been used for many rheumatologic diseases, toxicity limits its usefulness in many patients. Polymyositis/", "tokenized_content": [2, 10939, 4467, 3902, 3, 2876, 46, 17, 25142, 3812, 2258, 2252, 2251, 1958, 3086, 10939, 4467, 3902, 16, 5532, 8183, 2496, 13991, 1922, 3086, 2132, 18, 3491, 25749, 12924, 3600, 3]}, "items": [{"id": "p_4146", "content": "Rheumatic Diseases [SEP] Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or me", "score": 1, "type": null, "tokenized_content": [2, 22806, 3902, 3, 4414, 1927, 14948, 2960, 16, 4369, 1920, 12648, 1930, 2712, 4061, 16, 4378, 2007, 4531, 16, 9174, 16, 2014, 2142, 3]}]}
{"query": {"id": "q_4147", "content": "toxicity [SEP]  D-penicillamine has been used for many rheumatologic diseases, toxicity limits its usefulness in many patients. Polymyositis/dermatomyo", "tokenized_content": [2, 5532, 3, 46, 17, 25142, 3812, 2258, 2252, 2251, 1958, 3086, 10939, 4467, 3902, 16, 5532, 8183, 2496, 13991, 1922, 3086, 2132, 18, 3491, 25749, 12924, 3600, 19, 13467, 3542, 3]}, "items": [{"id": "p_4147", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4148", "content": "Polymyositis [SEP] ogic diseases, toxicity limits its usefulness in many patients. Polymyositis/dermatomyositis can develop as one of the autoimmune complicati", "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 17395, 1935, 3902, 16, 5532, 8183, 2496, 13991, 1922, 3086, 2132, 18, 3491, 25749, 12924, 3600, 19, 13467, 3542, 19976, 2112, 2392, 1966, 2340, 1927, 3]}, "items": [{"id": "p_4148", "content": "Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi", "score": 1, "type": null, "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3902, 4378, 2007, 4531, 5884, 3137, 7848, 18, 2052, 2278, 4704, 1966, 1925, 3939, 2014, 3724, 2625, 2458, 11980, 3]}]}
{"query": {"id": "q_4149", "content": "dermatomyositis [SEP] , toxicity limits its usefulness in many patients. Polymyositis/dermatomyositis can develop as one of the autoimmune complications of D-penicil", "tokenized_content": [2, 13467, 3542, 19976, 3, 16, 5532, 8183, 2496, 13991, 1922, 3086, 2132, 18, 3491, 25749, 12924, 3600, 19, 13467, 3542, 19976, 2112, 2392, 1966, 2340, 1927, 1920, 8904, 5021, 1927, 3]}, "items": [{"id": "p_4149", "content": "Dermatomyositis [SEP] A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash", "score": 1, "type": null, "tokenized_content": [2, 13467, 3542, 19976, 3, 43, 25440, 2014, 3724, 3769, 2573, 1927, 3760, 1930, 4407, 16, 4961, 2007, 6863, 3760, 12175, 1930, 43, 6293, 4407, 18469, 3]}]}
{"query": {"id": "q_4150", "content": "primary biliary cirrhosis [SEP] ts exact pathogenesis remains unclear. We report a patient with primary biliary cirrhosis, who developed polymyositis while receiving D-penicillamine the", "tokenized_content": [2, 3065, 13210, 11260, 3, 4894, 6368, 6559, 4497, 6390, 18, 2038, 3809, 43, 2774, 1956, 3065, 13210, 11260, 16, 2746, 3530, 3491, 25749, 12924, 3600, 2679, 5962, 46, 17, 25142, 3]}, "items": [{"id": "p_4150", "content": "Liver Cirrhosis, Biliary [SEP] FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts ", "score": 1, "type": null, "tokenized_content": [2, 3568, 11260, 16, 13210, 3, 6769, 1927, 1920, 6095, 15214, 2810, 1942, 10849, 1927, 9619, 3426, 12, 30086, 13, 1922, 1920, 22323, 2014, 29086, 9619, 19277, 3]}]}
{"query": {"id": "q_4151", "content": "polymyositis [SEP]  report a patient with primary biliary cirrhosis, who developed polymyositis while receiving D-penicillamine therapy. We described the speci", "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3809, 43, 2774, 1956, 3065, 13210, 11260, 16, 2746, 3530, 3491, 25749, 12924, 3600, 2679, 5962, 46, 17, 25142, 3812, 3181, 18, 2038, 2910, 1920, 3]}, "items": [{"id": "p_4151", "content": "Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi", "score": 1, "type": null, "tokenized_content": [2, 3491, 25749, 12924, 3600, 3, 3902, 4378, 2007, 4531, 5884, 3137, 7848, 18, 2052, 2278, 4704, 1966, 1925, 3939, 2014, 3724, 2625, 2458, 11980, 3]}]}
{"query": {"id": "q_4152", "content": "nifedipine [SEP] Photodistributed nifedipine-induced facial telangiectasia.", "tokenized_content": [2, 25968, 3, 10066, 15783, 4849, 25968, 17, 2719, 9567, 30512, 6646, 18, 3]}, "items": [{"id": "p_4152", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4153", "content": "telangiectasia [SEP] Photodistributed nifedipine-induced facial telangiectasia.", "tokenized_content": [2, 30512, 6646, 3, 10066, 15783, 4849, 25968, 17, 2719, 9567, 30512, 6646, 18, 3]}, "items": [{"id": "p_4153", "content": "Telangiectasis [SEP] Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most common", "score": 1, "type": null, "tokenized_content": [2, 30512, 3932, 3, 11047, 16470, 1927, 21604, 2877, 7208, 12, 16973, 31, 24332, 31, 8102, 3275, 13, 11124, 2858, 8083, 2312, 4518, 16, 2501, 3059, 3]}]}
{"query": {"id": "q_4154", "content": "nifedipine [SEP] Five months after starting nifedipine (Adalat), two patients developed photodistributed facial telang", "tokenized_content": [2, 25968, 3, 3628, 3221, 2256, 6801, 25968, 12, 29101, 1926, 13, 16, 2288, 2132, 3530, 10066, 15783, 4849, 9567, 5202, 2657, 3]}, "items": [{"id": "p_4154", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4155", "content": "Adalat [SEP] Five months after starting nifedipine (Adalat), two patients developed photodistributed facial telangiectasia", "tokenized_content": [2, 29101, 1926, 3, 3628, 3221, 2256, 6801, 25968, 12, 29101, 1926, 13, 16, 2288, 2132, 3530, 10066, 15783, 4849, 9567, 30512, 6646, 3]}, "items": [{"id": "p_4155", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4156", "content": "telangiectasia [SEP] dipine (Adalat), two patients developed photodistributed facial telangiectasia, which became more noticeable with time. Neither patient compla", "tokenized_content": [2, 30512, 6646, 3, 9137, 2053, 12, 29101, 1926, 13, 16, 2288, 2132, 3530, 10066, 15783, 4849, 9567, 30512, 6646, 16, 2154, 7935, 2253, 18795, 1956, 2367, 18, 7132, 2774, 6581, 3]}, "items": [{"id": "p_4156", "content": "Telangiectasis [SEP] Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most common", "score": 1, "type": null, "tokenized_content": [2, 30512, 3932, 3, 11047, 16470, 1927, 21604, 2877, 7208, 12, 16973, 31, 24332, 31, 8102, 3275, 13, 11124, 2858, 8083, 2312, 4518, 16, 2501, 3059, 3]}]}
{"query": {"id": "q_4157", "content": "flushing [SEP] le with time. Neither patient complained of photosensitivity or flushing. Both patients reported a significant cosmetic improvement afte", "tokenized_content": [2, 2848, 6150, 1941, 3, 2071, 1956, 2367, 18, 7132, 2774, 26199, 1927, 27462, 3273, 2014, 2848, 6150, 1941, 18, 2321, 2132, 2568, 43, 2228, 21164, 4990, 2221, 2057, 3]}, "items": [{"id": "p_4157", "content": "Flushing [SEP] A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 6150, 1941, 3, 43, 6809, 2312, 5233, 1941, 1927, 1920, 6171, 1988, 2278, 1998, 2810, 1942, 9087, 16, 4908, 4195, 16, 28187, 16, 3071, 16, 2014, 43, 2573, 2585, 18, 3]}]}
{"query": {"id": "q_4158", "content": "amlodipine [SEP]  discontinuing the drug. One commenced the closely related drug amlodipine 3 years later, with recurrence of telangiectasia. The photodist", "tokenized_content": [2, 9508, 26584, 3, 9035, 13768, 1920, 2838, 18, 2340, 26779, 1920, 6538, 2712, 2838, 9508, 26584, 23, 2739, 3690, 16, 1956, 6339, 1927, 30512, 6646, 18, 1920, 10066, 15783, 1031, 3]}, "items": [{"id": "p_4158", "content": "Amlodipine [SEP] A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.\n   ", "score": 1, "type": null, "tokenized_content": [2, 9508, 26584, 3, 43, 2815, 17, 8290, 11842, 18425, 5802, 5016, 4999, 14580, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 1930, 5579, 18, 3]}]}
{"query": {"id": "q_4159", "content": "Nephrotoxicity [SEP] Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphata", "tokenized_content": [2, 27880, 3, 27880, 1927, 17640, 1921, 43, 1930, 30269, 30, 3523, 1927, 19555, 2766, 5499, 3]}, "items": [{"id": "p_4159", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4160", "content": "cyclosporin A [SEP] Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase.", "tokenized_content": [2, 17640, 1921, 43, 3, 27880, 1927, 17640, 1921, 43, 1930, 30269, 30, 3523, 1927, 19555, 8167, 18, 3]}, "items": [{"id": "p_4160", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4161", "content": "FK506 [SEP] Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase.", "tokenized_content": [2, 30269, 3, 27880, 1927, 17640, 1921, 43, 1930, 30269, 30, 3523, 1927, 19555, 8167, 18, 3]}, "items": [{"id": "p_4161", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4162", "content": "Cyclosporin A [SEP] Cyclosporin A (CsA; 50 mg/kg) and Fujimycine (FK506; 5 mg/kg), but not the re", "tokenized_content": [2, 17640, 1921, 43, 3, 17640, 1921, 43, 12, 12993, 31, 2761, 2786, 19, 3621, 13, 1930, 20108, 1980, 4636, 1021, 12, 30269, 31, 25, 2786, 19, 3621, 13, 16, 2308, 3]}, "items": [{"id": "p_4162", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4163", "content": "CsA [SEP] Cyclosporin A (CsA; 50 mg/kg) and Fujimycine (FK506; 5 mg/kg), but not the related", "tokenized_content": [2, 12993, 3, 17640, 1921, 43, 12, 12993, 31, 2761, 2786, 19, 3621, 13, 1930, 20108, 1980, 4636, 1021, 12, 30269, 31, 25, 2786, 19, 3621, 13, 16, 2308, 2084, 1920, 3]}, "items": [{"id": "p_4163", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4164", "content": "Fujimycine [SEP] Cyclosporin A (CsA; 50 mg/kg) and Fujimycine (FK506; 5 mg/kg), but not the related macrolide immunosuppressa", "tokenized_content": [2, 20108, 1980, 4636, 1021, 3, 17640, 1921, 43, 12, 12993, 31, 2761, 2786, 19, 3621, 13, 1930, 20108, 1980, 4636, 1021, 12, 30269, 31, 25, 2786, 19, 3621, 13, 16, 3]}, "items": [{"id": "p_4164", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4165", "content": "FK506 [SEP] Cyclosporin A (CsA; 50 mg/kg) and Fujimycine (FK506; 5 mg/kg), but not the related macrolide immunosuppressant rapa", "tokenized_content": [2, 30269, 3, 17640, 1921, 43, 12, 12993, 31, 2761, 2786, 19, 3621, 13, 1930, 20108, 1980, 4636, 1021, 12, 30269, 31, 25, 2786, 19, 3621, 13, 16, 2308, 2084, 1920, 3]}, "items": [{"id": "p_4165", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4166", "content": "macrolide [SEP]  50 mg/kg) and Fujimycine (FK506; 5 mg/kg), but not the related macrolide immunosuppressant rapamycin (5 mg/kg), caused a reduction of gl", "tokenized_content": [2, 23929, 2261, 3, 2761, 2786, 19, 3621, 13, 1930, 20108, 1980, 4636, 1021, 12, 30269, 31, 25, 2786, 19, 3621, 13, 16, 2308, 2084, 1920, 2712, 23929, 2261, 27996, 2031, 3]}, "items": [{"id": "p_4166", "content": "Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ", "score": 1, "type": null, "tokenized_content": [2, 23929, 3726, 3, 43, 2210, 1927, 3868, 17514, 21924, 13153, 4300, 5333, 2007, 4659, 7140, 1927, 3137, 24682, 1036, 3637, 2301, 2460, 43, 3103, 12, 2357, 3]}]}
{"query": {"id": "q_4167", "content": "rapamycin [SEP] K506; 5 mg/kg), but not the related macrolide immunosuppressant rapamycin (5 mg/kg), caused a reduction of glomerular filtration rate, de", "tokenized_content": [2, 11100, 3, 27157, 14265, 31, 25, 2786, 19, 3621, 13, 16, 2308, 2084, 1920, 2712, 23929, 2261, 27996, 2031, 11100, 12, 25, 2786, 19, 3621, 13, 16, 4189, 43, 3378, 3]}, "items": [{"id": "p_4167", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4168", "content": "hypertrophy [SEP]  rate, degenerative changes of proximal tubular epithelium, and hypertrophy of the juxtaglomerular apparatus in male Wistar rats when given", "tokenized_content": [2, 11014, 3, 2769, 16, 15676, 2840, 1927, 6863, 11755, 8081, 16, 1930, 11014, 1927, 1920, 21887, 15915, 4528, 2168, 11161, 1922, 4005, 15668, 3615, 2469, 3258, 3]}, "items": [{"id": "p_4168", "content": "Hypertrophy [SEP] General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor ", "score": 1, "type": null, "tokenized_content": [2, 11014, 3, 3335, 2760, 1922, 9390, 1927, 43, 3131, 2014, 3090, 2810, 1942, 2024, 16363, 1930, 4858, 1927, 13315, 1930, 21417, 16, 2084, 2810, 1942, 2798, 3]}]}
{"query": {"id": "q_4169", "content": "toxicity [SEP] en given for 10 days. The molecular mechanisms of CsA and FK506 toxicity were investigated. Cyclophilin A and FK506-binding protein, the", "tokenized_content": [2, 5532, 3, 2066, 3258, 1958, 2119, 3000, 18, 1920, 3272, 3531, 1927, 12993, 1930, 30269, 5532, 1985, 3845, 18, 20585, 7969, 7782, 43, 1930, 30269, 17, 2743, 2213, 16, 1920, 3]}, "items": [{"id": "p_4169", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4170", "content": "nephrotoxic [SEP] sA and FK506, but not rapamycin. These results suggest that the nephrotoxic effects of CsA and FK506 is likely mediated through binding to ", "tokenized_content": [2, 22994, 10605, 3, 4611, 1930, 30269, 16, 2308, 2084, 11100, 18, 2144, 2274, 3220, 1988, 1920, 22994, 10605, 2564, 1927, 12993, 1930, 30269, 1977, 3205, 3434, 2596, 2743, 1942, 3]}, "items": [{"id": "p_4170", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4171", "content": "cerebral edema [SEP] Massive cerebral edema associated with fulminant hepatic failure in acetaminophen over", "tokenized_content": [2, 6329, 10144, 3, 12944, 6329, 10144, 2458, 1956, 5257, 8547, 2031, 6095, 4574, 1922, 23311, 2338, 3]}, "items": [{"id": "p_4171", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_4172", "content": "hepatic failure [SEP] Massive cerebral edema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompressi", "tokenized_content": [2, 6095, 4574, 3, 12944, 6329, 10144, 2458, 1956, 5257, 8547, 2031, 6095, 4574, 1922, 23311, 21090, 30, 3216, 2770, 1927, 13598, 9400, 2109, 1033, 3]}, "items": [{"id": "p_4172", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_4173", "content": "acetaminophen [SEP] ive cerebral edema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompression.", "tokenized_content": [2, 23311, 3, 4370, 1021, 6329, 10144, 2458, 1956, 5257, 8547, 2031, 6095, 4574, 1922, 23311, 21090, 30, 3216, 2770, 1927, 13598, 20031, 18, 3]}, "items": [{"id": "p_4173", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4174", "content": "overdose [SEP] dema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompression.", "tokenized_content": [2, 21090, 3, 2521, 1019, 2458, 1956, 5257, 8547, 2031, 6095, 4574, 1922, 23311, 21090, 30, 3216, 2770, 1927, 13598, 20031, 18, 3]}, "items": [{"id": "p_4174", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4175", "content": "Cerebral edema [SEP] Cerebral edema may complicate the course of fulminant hepatic failure. Respons", "tokenized_content": [2, 6329, 10144, 3, 6329, 10144, 2278, 27687, 1920, 4914, 1927, 5257, 8547, 2031, 6095, 4574, 18, 2364, 3]}, "items": [{"id": "p_4175", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_4176", "content": "fulminant hepatic failure [SEP] Cerebral edema may complicate the course of fulminant hepatic failure. Response to conventional therapy has been disappointing. We pr", "tokenized_content": [2, 5257, 8547, 2031, 6095, 4574, 3, 6329, 10144, 2278, 27687, 1920, 4914, 1927, 5257, 8547, 2031, 6095, 4574, 18, 2644, 1942, 5552, 3181, 2258, 2252, 29806, 2104, 18, 2038, 2033, 3]}, "items": [{"id": "p_4176", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_4177", "content": "acetaminophen [SEP] therapy has been disappointing. We present a patient with fatal acetaminophen-induced fulminant hepatic failure, with signs and symptoms of c", "tokenized_content": [2, 23311, 3, 3181, 2258, 2252, 29806, 2104, 18, 2038, 2481, 43, 2774, 1956, 11990, 23311, 17, 2719, 5257, 8547, 2031, 6095, 4574, 16, 1956, 6879, 1930, 3601, 1927, 45, 3]}, "items": [{"id": "p_4177", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4178", "content": "cerebral edema [SEP] n-induced fulminant hepatic failure, with signs and symptoms of cerebral edema, unresponsive to conventional medical therapy. Cranial decompre", "tokenized_content": [2, 6329, 10144, 3, 56, 17, 2719, 5257, 8547, 2031, 6095, 4574, 16, 1956, 6879, 1930, 3601, 1927, 6329, 10144, 16, 27327, 1942, 5552, 3423, 3181, 18, 13598, 9400, 4060, 3]}, "items": [{"id": "p_4178", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_4179", "content": "Gentamicin [SEP] Gentamicin nephropathy in a neonate.", "tokenized_content": [2, 17144, 3, 17144, 15582, 1922, 43, 27586, 18, 3]}, "items": [{"id": "p_4179", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_4180", "content": "nephropathy [SEP] Gentamicin nephropathy in a neonate.", "tokenized_content": [2, 15582, 3, 17144, 15582, 1922, 43, 27586, 18, 3]}, "items": [{"id": "p_4180", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4181", "content": "acute renal failure [SEP] e clinical and autopsy findings in a premature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are ", "tokenized_content": [2, 3939, 4604, 4574, 3, 47, 2535, 1930, 16740, 3056, 1922, 43, 9839, 16099, 2746, 8545, 1927, 3939, 4604, 4574, 2256, 3181, 1956, 17144, 12, 25, 2786, 19, 3621, 19, 3007, 3]}, "items": [{"id": "p_4181", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_4182", "content": "gentamicin [SEP] emature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamici", "tokenized_content": [2, 17144, 3, 23444, 4040, 16099, 2746, 8545, 1927, 3939, 4604, 4574, 2256, 3181, 1956, 17144, 12, 25, 2786, 19, 3621, 19, 3007, 13, 1930, 9957, 2032, 3549, 18, 1920, 3256, 3]}, "items": [{"id": "p_4182", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_4183", "content": "penicillin [SEP] e renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamicin concentration had reached t", "tokenized_content": [2, 9957, 3, 47, 4604, 4574, 2256, 3181, 1956, 17144, 12, 25, 2786, 19, 3621, 19, 3007, 13, 1930, 9957, 2032, 3549, 18, 1920, 3256, 17144, 3110, 2430, 6690, 62, 3]}, "items": [{"id": "p_4183", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_4184", "content": "anuria [SEP] he serum gentamicin concentration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diasta", "tokenized_content": [2, 1925, 8754, 3, 2234, 3256, 17144, 3110, 2430, 6690, 6161, 2428, 2469, 1925, 8754, 3530, 18, 6466, 12922, 2687, 25214, 12, 9233, 13, 2843, 16, 8455, 1019, 3]}, "items": [{"id": "p_4184", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_4185", "content": "periodic acid [SEP] ration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diastase resistant cytoplasmic inclusion", "tokenized_content": [2, 12922, 2687, 3, 12488, 2430, 6690, 6161, 2428, 2469, 1925, 8754, 3530, 18, 6466, 12922, 2687, 25214, 12, 9233, 13, 2843, 16, 8455, 2051, 4910, 6823, 6125, 3]}, "items": [{"id": "p_4185", "content": "Periodic Acid [SEP] A strong oxidizing agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12922, 2687, 3, 43, 3206, 23669, 5899, 18, 3]}]}
{"query": {"id": "q_4186", "content": "carcinogenic [SEP] Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitros", "tokenized_content": [2, 20711, 3, 2246, 17, 20711, 4615, 1927, 3037, 18986, 3258, 7159, 1956, 18622, 8635, 1997, 1951, 3]}, "items": [{"id": "p_4186", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_4187", "content": "phenobarbital [SEP] Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.", "tokenized_content": [2, 3037, 18986, 3, 2246, 17, 20711, 4615, 1927, 3037, 18986, 3258, 7159, 1956, 18622, 8635, 1997, 17454, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4187", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_4188", "content": "diethylnitrosamine [SEP] -carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.", "tokenized_content": [2, 18622, 8635, 1997, 17454, 3, 17, 20711, 4615, 1927, 3037, 18986, 3258, 7159, 1956, 18622, 8635, 1997, 17454, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4188", "content": "Diethylnitrosamine [SEP] A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18622, 8635, 1997, 17454, 3, 43, 16665, 3812, 10533, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 3]}]}
{"query": {"id": "q_4189", "content": "phenobarbital [SEP] esent work has been planned in order to elucidate the effect of phenobarbital (PB: 15 mg per rat of ingested dose) on carcinogenesis when it ", "tokenized_content": [2, 3037, 18986, 3, 2376, 1939, 2778, 2258, 2252, 10842, 1922, 3238, 1942, 9970, 1920, 2495, 1927, 3037, 18986, 12, 5242, 30, 2461, 2786, 2079, 3067, 1927, 20833, 3253, 13, 1990, 3]}, "items": [{"id": "p_4189", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_4190", "content": "PB [SEP] been planned in order to elucidate the effect of phenobarbital (PB: 15 mg per rat of ingested dose) on carcinogenesis when it is a", "tokenized_content": [2, 5242, 3, 2252, 10842, 1922, 3238, 1942, 9970, 1920, 2495, 1927, 3037, 18986, 12, 5242, 30, 2461, 2786, 2079, 3067, 1927, 20833, 3253, 13, 1990, 12559, 2469, 2176, 1977, 43, 3]}, "items": [{"id": "p_4190", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_4191", "content": "carcinogenesis [SEP] effect of phenobarbital (PB: 15 mg per rat of ingested dose) on carcinogenesis when it is administered simultaneously with diethylnitrosamine ", "tokenized_content": [2, 12559, 3, 2495, 1927, 3037, 18986, 12, 5242, 30, 2461, 2786, 2079, 3067, 1927, 20833, 3253, 13, 1990, 12559, 2469, 2176, 1977, 5254, 7159, 1956, 18622, 8635, 1997, 17454, 3]}, "items": [{"id": "p_4191", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_4192", "content": "diethylnitrosamine [SEP] ) on carcinogenesis when it is administered simultaneously with diethylnitrosamine (DEN: 10 mg/kg/day). Wistar rats (180 g) were treated by DEN al", "tokenized_content": [2, 18622, 8635, 1997, 17454, 3, 13, 1990, 12559, 2469, 2176, 1977, 5254, 7159, 1956, 18622, 8635, 1997, 17454, 12, 4533, 30, 2119, 2786, 19, 3621, 19, 3007, 13, 18, 15668, 3]}, "items": [{"id": "p_4192", "content": "Diethylnitrosamine [SEP] A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18622, 8635, 1997, 17454, 3, 43, 16665, 3812, 10533, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 3]}]}
{"query": {"id": "q_4193", "content": "DEN [SEP] when it is administered simultaneously with diethylnitrosamine (DEN: 10 mg/kg/day). Wistar rats (180 g) were treated by DEN alone o", "tokenized_content": [2, 4533, 3, 2469, 2176, 1977, 5254, 7159, 1956, 18622, 8635, 1997, 17454, 12, 4533, 30, 2119, 2786, 19, 3621, 19, 3007, 13, 18, 15668, 3615, 12, 8585, 49, 13, 1985, 3]}, "items": [{"id": "p_4193", "content": "Diethylnitrosamine [SEP] A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18622, 8635, 1997, 17454, 3, 43, 16665, 3812, 10533, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 3]}]}
{"query": {"id": "q_4194", "content": "hepatocarcinogenesis [SEP]  DEN + PB during 2, 4 and 6 weeks according to our schedule for hepatocarcinogenesis. After the end of the treatment, the number and the size of ind", "tokenized_content": [2, 5746, 7907, 3761, 3, 4533, 15, 5242, 2409, 22, 16, 24, 1930, 26, 3625, 3147, 1942, 2342, 11660, 1958, 5746, 7907, 3761, 18, 2256, 1920, 2482, 1927, 1920, 2311, 16, 3]}, "items": [{"id": "p_4194", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_4195", "content": "preneoplastic foci [SEP]  the treatment, the number and the size of induced PAS positive preneoplastic foci was significantly reduced when PB was given simultaneously with", "tokenized_content": [2, 9972, 1021, 9969, 10334, 3, 1920, 2311, 16, 1920, 2529, 1930, 1920, 3081, 1927, 2719, 9233, 2843, 9972, 1021, 9969, 10334, 1982, 2567, 3028, 2469, 5242, 1982, 3258, 7159, 1956, 3]}, "items": [{"id": "p_4195", "content": "Precancerous Conditions [SEP] Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 24436, 15895, 6506, 1957, 2961, 3, 6598, 4028, 1988, 5370, 10042, 1942, 5433, 6558, 18, 12, 2037, 19638, 4702, 16, 3225, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_4196", "content": "tumor [SEP] s. In DEN + PB treated rats, the survival was prolonged and the tumor incidence decreased as compared with the results obtained by DE", "tokenized_content": [2, 2798, 3, 61, 18, 1922, 4533, 15, 5242, 2868, 3615, 16, 1920, 3298, 1982, 7171, 1930, 1920, 2798, 4332, 3261, 1966, 2452, 1956, 1920, 2274, 2926, 2007, 2028, 3]}, "items": [{"id": "p_4196", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4197", "content": "precancerous lesions [SEP] ffect acts on the initiation as well as on the promotion of the precancerous lesions. Biochemical investigations are in progress to obtain more info", "tokenized_content": [2, 24436, 15895, 6506, 1957, 4518, 3, 10735, 2089, 8016, 1990, 1920, 6035, 1966, 2486, 1966, 1990, 1920, 10693, 1927, 1920, 24436, 15895, 6506, 1957, 4518, 18, 6503, 7873, 2032, 1922, 3]}, "items": [{"id": "p_4197", "content": "Precancerous Conditions [SEP] Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 24436, 15895, 6506, 1957, 2961, 3, 6598, 4028, 1988, 5370, 10042, 1942, 5433, 6558, 18, 12, 2037, 19638, 4702, 16, 3225, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_4198", "content": "rigidity [SEP] Post-operative rigidity after fentanyl administration.", "tokenized_content": [2, 20471, 3, 2753, 17, 8116, 20471, 2256, 20311, 4183, 18, 3]}, "items": [{"id": "p_4198", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_4199", "content": "fentanyl [SEP] Post-operative rigidity after fentanyl administration.", "tokenized_content": [2, 20311, 3, 2753, 17, 8116, 20471, 2256, 20311, 4183, 18, 3]}, "items": [{"id": "p_4199", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_4200", "content": "rigidity [SEP] A case of thoraco-abdominal rigidity leading to respiratory failure is described in the post-operati", "tokenized_content": [2, 20471, 3, 43, 3087, 1927, 9147, 1037, 17, 6900, 20471, 4523, 1942, 5481, 4574, 1977, 2910, 1922, 1920, 2753, 17, 3641, 1968, 3]}, "items": [{"id": "p_4200", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_4201", "content": "respiratory failure [SEP] A case of thoraco-abdominal rigidity leading to respiratory failure is described in the post-operative period in an elderly patient", "tokenized_content": [2, 5481, 4574, 3, 43, 3087, 1927, 9147, 1037, 17, 6900, 20471, 4523, 1942, 5481, 4574, 1977, 2910, 1922, 1920, 2753, 17, 8116, 3047, 1922, 1925, 7354, 2774, 3]}, "items": [{"id": "p_4201", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4202", "content": "fentanyl [SEP] ve period in an elderly patient who received a moderate dose of fentanyl. This was successfully reversed by naloxone. The mechanisms pos", "tokenized_content": [2, 20311, 3, 3428, 3047, 1922, 1925, 7354, 2774, 2746, 4004, 43, 5086, 3253, 1927, 20311, 18, 2052, 1982, 6664, 9432, 2007, 21926, 18, 1920, 3531, 2159, 3]}, "items": [{"id": "p_4202", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_4203", "content": "naloxone [SEP]  a moderate dose of fentanyl. This was successfully reversed by naloxone. The mechanisms possibly implicated in this accident are discus", "tokenized_content": [2, 21926, 3, 43, 5086, 3253, 1927, 20311, 18, 2052, 1982, 6664, 9432, 2007, 21926, 18, 1920, 3531, 6553, 6835, 1922, 2052, 17713, 2032, 2863, 1957, 3]}, "items": [{"id": "p_4203", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_4204", "content": "psychosis [SEP] Postpartum psychosis induced by bromocriptine.", "tokenized_content": [2, 15489, 3, 13171, 15489, 2719, 2007, 21392, 4093, 2053, 18, 3]}, "items": [{"id": "p_4204", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_4205", "content": "bromocriptine [SEP] Postpartum psychosis induced by bromocriptine.", "tokenized_content": [2, 21392, 4093, 2053, 3, 13171, 15489, 2719, 2007, 21392, 4093, 2053, 18, 3]}, "items": [{"id": "p_4205", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_4206", "content": "psychiatric [SEP] Two multigravida patients with no prior psychiatric history were seen with postpartum psychosis, having received br", "tokenized_content": [2, 7652, 3, 2288, 2779, 2299, 9188, 3825, 2132, 1956, 2239, 3432, 7652, 4403, 1985, 3945, 1956, 13171, 15489, 16, 4537, 4004, 2387, 3]}, "items": [{"id": "p_4206", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4207", "content": "psychosis [SEP] nts with no prior psychiatric history were seen with postpartum psychosis, having received bromocriptine for inhibition of lactation. Bro", "tokenized_content": [2, 15489, 3, 17969, 1956, 2239, 3432, 7652, 4403, 1985, 3945, 1956, 13171, 15489, 16, 4537, 4004, 21392, 4093, 2053, 1958, 3523, 1927, 17467, 18, 4188, 3]}, "items": [{"id": "p_4207", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_4208", "content": "bromocriptine [SEP] ic history were seen with postpartum psychosis, having received bromocriptine for inhibition of lactation. Bromocriptine given in high doses ", "tokenized_content": [2, 21392, 4093, 2053, 3, 3996, 4403, 1985, 3945, 1956, 13171, 15489, 16, 4537, 4004, 21392, 4093, 2053, 1958, 3523, 1927, 17467, 18, 21392, 4093, 2053, 3258, 1922, 2149, 5312, 3]}, "items": [{"id": "p_4208", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_4209", "content": "inhibition of lactation [SEP] en with postpartum psychosis, having received bromocriptine for inhibition of lactation. Bromocriptine given in high doses has been associated with psy", "tokenized_content": [2, 3523, 1927, 17467, 3, 2066, 1956, 13171, 15489, 16, 4537, 4004, 21392, 4093, 2053, 1958, 3523, 1927, 17467, 18, 21392, 4093, 2053, 3258, 1922, 2149, 5312, 2258, 2252, 2458, 1956, 3]}, "items": [{"id": "p_4209", "content": "Lactation Disorders [SEP] Disturbances of MILK secretion in either SEX, not necessarily related to PREGNANCY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17467, 4414, 3, 12654, 1927, 7126, 5512, 1922, 3108, 3486, 16, 2084, 9409, 2712, 1942, 5284, 18, 3]}]}
{"query": {"id": "q_4210", "content": "Bromocriptine [SEP] sis, having received bromocriptine for inhibition of lactation. Bromocriptine given in high doses has been associated with psychosis in patie", "tokenized_content": [2, 21392, 4093, 2053, 3, 19149, 16, 4537, 4004, 21392, 4093, 2053, 1958, 3523, 1927, 17467, 18, 21392, 4093, 2053, 3258, 1922, 2149, 5312, 2258, 2252, 2458, 1956, 15489, 1922, 2091, 3]}, "items": [{"id": "p_4210", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_4211", "content": "Parkinson's disease [SEP] en associated with psychosis in patients receiving the drug for Parkinson's disease. These cases demonstrate that bromocriptine may cause psychosis", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2066, 2458, 1956, 15489, 1922, 2132, 5962, 1920, 2838, 1958, 10124, 11, 61, 2573, 18, 2144, 2919, 4504, 1988, 21392, 4093, 2053, 2278, 3936, 15489, 3]}, "items": [{"id": "p_4211", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4212", "content": "cardiotoxicity [SEP] A prospective study on the dose dependency of cardiotoxicity induced by mitomycin C.", "tokenized_content": [2, 30490, 3, 43, 6315, 2161, 1990, 1920, 3253, 14604, 1927, 30490, 2719, 2007, 28154, 45, 18, 3]}, "items": [{"id": "p_4212", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4213", "content": "mitomycin C [SEP] ctive study on the dose dependency of cardiotoxicity induced by mitomycin C.", "tokenized_content": [2, 28154, 45, 3, 3369, 2320, 2161, 1990, 1920, 3253, 14604, 1927, 30490, 2719, 2007, 28154, 45, 18, 3]}, "items": [{"id": "p_4213", "content": "Mitomycin [SEP] An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS caus", "score": 1, "type": null, "tokenized_content": [2, 28154, 3, 1925, 29128, 9969, 7267, 4152, 2007, 22874, 22014, 10984, 4575, 20490, 1036, 18, 2176, 1977, 2340, 1927, 1920, 2273, 17, 2014, 5083, 17, 3183, 28912, 4820, 3092, 3]}]}
{"query": {"id": "q_4214", "content": "mitomycin C [SEP] Since 1975 mitomycin C (MMC) has been suggested to be cardiotoxic, especially when com", "tokenized_content": [2, 28154, 45, 3, 3328, 16649, 28154, 45, 12, 21203, 13, 2258, 2252, 3978, 1942, 1998, 21129, 4575, 18068, 1030, 16, 4369, 2469, 2008, 3]}, "items": [{"id": "p_4214", "content": "Mitomycin [SEP] An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS caus", "score": 1, "type": null, "tokenized_content": [2, 28154, 3, 1925, 29128, 9969, 7267, 4152, 2007, 22874, 22014, 10984, 4575, 20490, 1036, 18, 2176, 1977, 2340, 1927, 1920, 2273, 17, 2014, 5083, 17, 3183, 28912, 4820, 3092, 3]}]}
{"query": {"id": "q_4215", "content": "MMC [SEP] Since 1975 mitomycin C (MMC) has been suggested to be cardiotoxic, especially when combined", "tokenized_content": [2, 21203, 3, 3328, 16649, 28154, 45, 12, 21203, 13, 2258, 2252, 3978, 1942, 1998, 21129, 4575, 18068, 1030, 16, 4369, 2469, 4252, 3]}, "items": [{"id": "p_4215", "content": "Mitomycin [SEP] An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS caus", "score": 1, "type": null, "tokenized_content": [2, 28154, 3, 1925, 29128, 9969, 7267, 4152, 2007, 22874, 22014, 10984, 4575, 20490, 1036, 18, 2176, 1977, 2340, 1927, 1920, 2273, 17, 2014, 5083, 17, 3183, 28912, 4820, 3092, 3]}]}
{"query": {"id": "q_4216", "content": "cardiotoxic [SEP] Since 1975 mitomycin C (MMC) has been suggested to be cardiotoxic, especially when combined with or given following doxorubicin. ", "tokenized_content": [2, 21129, 4575, 18068, 1030, 3, 3328, 16649, 28154, 45, 12, 21203, 13, 2258, 2252, 3978, 1942, 1998, 21129, 4575, 18068, 1030, 16, 4369, 2469, 4252, 1956, 2014, 3258, 2894, 12377, 3]}, "items": [{"id": "p_4216", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4217", "content": "doxorubicin [SEP] e cardiotoxic, especially when combined with or given following doxorubicin. Data on dose dependency or incidence concerning this side effe", "tokenized_content": [2, 12377, 3, 47, 21129, 4575, 18068, 1030, 16, 4369, 2469, 4252, 1956, 2014, 3258, 2894, 12377, 18, 2230, 1990, 3253, 14604, 2014, 4332, 8679, 2052, 4159, 2121, 1021, 3]}, "items": [{"id": "p_4217", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4218", "content": "cardiac failure [SEP] luated per cumulative dose level. One of the patients developed cardiac failure after 30 mg m-2 MMC and only 150 mg m-2 doxorubicin. The cardia", "tokenized_content": [2, 4435, 4574, 3, 10908, 1981, 2079, 8274, 3253, 2237, 18, 2340, 1927, 1920, 2132, 3530, 4435, 4574, 2256, 2627, 2786, 55, 17, 22, 21203, 1930, 2444, 5493, 2786, 55, 17, 3]}, "items": [{"id": "p_4218", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4219", "content": "cardiotoxicity [SEP] old pressor test. None of the other patients developed clinical cardiotoxicity, nor did the studied parameters change. The literature on this ", "tokenized_content": [2, 30490, 3, 4156, 3477, 1924, 2648, 18, 6046, 1927, 1920, 2303, 2132, 3530, 2535, 30490, 16, 3990, 2811, 1920, 3942, 3673, 3185, 18, 1920, 4431, 1990, 2052, 3]}, "items": [{"id": "p_4219", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4220", "content": "Phlorizin [SEP] Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity i", "tokenized_content": [2, 29554, 6658, 22030, 1022, 3, 29554, 6658, 22030, 1022, 17, 2719, 7533, 8754, 3731, 2084, 4625, 17144, 27880, 51, 3]}, "items": [{"id": "p_4220", "content": "Phlorhizin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29554, 14514, 2061, 1921, 3, 3]}]}
{"query": {"id": "q_4221", "content": "glycosuria [SEP] Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.", "tokenized_content": [2, 7533, 8754, 3, 29554, 6658, 22030, 1022, 17, 2719, 7533, 8754, 3731, 2084, 4625, 17144, 27880, 1922, 3615, 18, 3]}, "items": [{"id": "p_4221", "content": "Glycosuria [SEP] The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to H", "score": 1, "type": null, "tokenized_content": [2, 7533, 8754, 3, 1920, 7818, 1927, 1925, 20756, 3103, 4351, 1927, 3817, 1922, 1920, 6960, 16, 2427, 1966, 2253, 2254, 4599, 2786, 19, 3007, 1922, 4440, 18, 2176, 2112, 1998, 2810, 1942, 50, 3]}]}
{"query": {"id": "q_4222", "content": "gentamicin [SEP] Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.", "tokenized_content": [2, 17144, 3, 29554, 6658, 22030, 1022, 17, 2719, 7533, 8754, 3731, 2084, 4625, 17144, 27880, 1922, 3615, 18, 3]}, "items": [{"id": "p_4222", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_4223", "content": "nephrotoxicity [SEP] Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.", "tokenized_content": [2, 27880, 3, 29554, 6658, 22030, 1022, 17, 2719, 7533, 8754, 3731, 2084, 4625, 17144, 27880, 1922, 3615, 18, 3]}, "items": [{"id": "p_4223", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4224", "content": "streptozotocin [SEP] Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (gly", "tokenized_content": [2, 26492, 3, 2882, 3615, 1956, 26492, 17, 2719, 4032, 9695, 12, 3931, 13, 2162, 43, 2149, 19661, 2137, 27718, 12, 3376, 3]}, "items": [{"id": "p_4224", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_4225", "content": "diabetes mellitus [SEP] Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day)", "tokenized_content": [2, 4032, 9695, 3, 2882, 3615, 1956, 26492, 17, 2719, 4032, 9695, 12, 3931, 13, 2162, 43, 2149, 19661, 2137, 27718, 12, 7533, 8754, 1927, 2119, 1942, 2369, 49, 19, 3007, 3]}, "items": [{"id": "p_4225", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_4226", "content": "DM [SEP] Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we", "tokenized_content": [2, 3931, 3, 2882, 3615, 1956, 26492, 17, 2719, 4032, 9695, 12, 3931, 13, 2162, 43, 2149, 19661, 2137, 27718, 12, 7533, 8754, 1927, 2119, 1942, 2369, 49, 19, 3007, 13, 3]}, "items": [{"id": "p_4226", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_4227", "content": "glycosuria [SEP] cin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be ", "tokenized_content": [2, 7533, 8754, 3, 10510, 17, 2719, 4032, 9695, 12, 3931, 13, 2162, 43, 2149, 19661, 2137, 27718, 12, 7533, 8754, 1927, 2119, 1942, 2369, 49, 19, 3007, 13, 16, 2038, 3]}, "items": [{"id": "p_4227", "content": "Glycosuria [SEP] The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to H", "score": 1, "type": null, "tokenized_content": [2, 7533, 8754, 3, 1920, 7818, 1927, 1925, 20756, 3103, 4351, 1927, 3817, 1922, 1920, 6960, 16, 2427, 1966, 2253, 2254, 4599, 2786, 19, 3007, 1922, 4440, 18, 2176, 2112, 1998, 2810, 1942, 50, 3]}]}
{"query": {"id": "q_4228", "content": "gentamicin [SEP] ed that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamic", "tokenized_content": [2, 17144, 3, 3347, 1988, 2052, 2278, 1922, 3131, 1998, 5061, 1958, 2310, 3554, 1942, 17144, 17, 2719, 3939, 4604, 4574, 12, 13720, 13, 18, 1920, 6202, 2037, 11994, 13514, 3]}, "items": [{"id": "p_4228", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_4229", "content": "acute renal failure [SEP]  part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studie", "tokenized_content": [2, 3939, 4604, 4574, 3, 3131, 1998, 5061, 1958, 2310, 3554, 1942, 17144, 17, 2719, 3939, 4604, 4574, 12, 13720, 13, 18, 1920, 6202, 2037, 17144, 27880, 1982, 2060, 2621, 3]}, "items": [{"id": "p_4229", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_4230", "content": "ARF [SEP] for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in ", "tokenized_content": [2, 13720, 3, 1958, 2310, 3554, 1942, 17144, 17, 2719, 3939, 4604, 4574, 12, 13720, 13, 18, 1920, 6202, 2037, 17144, 27880, 1982, 3942, 1922, 3]}, "items": [{"id": "p_4230", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_4231", "content": "nephrotoxicity [SEP] duced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis i", "tokenized_content": [2, 27880, 3, 10677, 1919, 3939, 4604, 4574, 12, 13720, 13, 18, 1920, 6202, 2037, 17144, 27880, 1982, 3942, 1922, 2447, 17, 6152, 3615, 1956, 3724, 19661, 2137, 27718, 51, 3]}, "items": [{"id": "p_4231", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4232", "content": "diabetic [SEP] he protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubula", "tokenized_content": [2, 6152, 3, 2234, 6202, 2037, 17144, 27880, 1982, 3942, 1922, 2447, 17, 6152, 3615, 1956, 3724, 19661, 2137, 27718, 2719, 2007, 23615, 1927, 25860, 1019, 3]}, "items": [{"id": "p_4232", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_4233", "content": "glucose [SEP] ats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (", "tokenized_content": [2, 3817, 3, 19904, 1956, 3724, 19661, 2137, 27718, 2719, 2007, 23615, 1927, 11755, 3817, 26287, 1956, 29554, 6658, 22030, 1022, 12, 58, 13, 18, 3931, 3615, 1956, 5809, 7533, 8754, 3]}, "items": [{"id": "p_4233", "content": "Glucose [SEP] A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in i", "score": 1, "type": null, "tokenized_content": [2, 3817, 3, 43, 3065, 4585, 1927, 3844, 1958, 5818, 7373, 18, 2176, 1977, 10414, 6966, 1930, 1977, 2435, 1922, 12953, 1930, 2303, 7516, 1927, 4793, 1922, 51, 3]}]}
{"query": {"id": "q_4234", "content": "phlorizin [SEP] uresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of", "tokenized_content": [2, 29554, 6658, 22030, 1022, 3, 6794, 8362, 2719, 2007, 23615, 1927, 11755, 3817, 26287, 1956, 29554, 6658, 22030, 1022, 12, 58, 13, 18, 3931, 3615, 1956, 5809, 7533, 8754, 12, 3]}, "items": [{"id": "p_4234", "content": "Phlorhizin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29554, 14514, 2061, 1921, 3, 3]}]}
{"query": {"id": "q_4235", "content": "P [SEP] ced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of th", "tokenized_content": [2, 58, 3, 19424, 2007, 23615, 1927, 11755, 3817, 26287, 1956, 29554, 6658, 22030, 1022, 12, 58, 13, 18, 3931, 3615, 1956, 5809, 7533, 8754, 12, 2551, 1922, 4647, 1942, 1988, 3]}, "items": [{"id": "p_4235", "content": "Phlorhizin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29554, 14514, 2061, 1921, 3, 3]}]}
{"query": {"id": "q_4236", "content": "Nephrotoxic [SEP] oup III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during", "tokenized_content": [2, 22994, 10605, 3, 17208, 1034, 4337, 12, 17144, 4298, 13, 1930, 2210, 4370, 12, 5809, 3931, 15, 17144, 13, 18, 22994, 10605, 5312, 12, 3040, 2786, 19, 3621, 3362, 3751, 3]}, "items": [{"id": "p_4236", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4237", "content": "renal dysfunction [SEP] /- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or ", "tokenized_content": [2, 4604, 5273, 3, 19, 17, 20, 18, 21, 49, 19, 3007, 16, 2058, 13, 16, 1930, 2239, 3183, 2014, 19599, 3095, 1927, 4604, 5273, 12, 3703, 8519, 22, 18, 21, 3]}, "items": [{"id": "p_4237", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4238", "content": "tubular necrosis [SEP] ne CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentam", "tokenized_content": [2, 11755, 7476, 3, 2069, 8519, 22, 18, 21, 15, 19, 17, 20, 18, 21, 2646, 19, 2360, 16, 14341, 3629, 4490, 2229, 8754, 13, 2014, 4293, 12, 11755, 7476, 3593, 3]}, "items": [{"id": "p_4238", "content": "Psittacosis [SEP] Infection with CHLAMYDOPHILA PSITTACI (formerly Chlamydia psittaci), transmitted to humans by inhalation of dust-borne contamina", "score": 1, "type": null, "tokenized_content": [2, 14748, 3519, 20682, 8362, 3, 2909, 1956, 14667, 7766, 14748, 3519, 28278, 12, 22397, 21079, 14748, 3519, 28278, 13, 16, 11019, 1942, 5209, 2007, 14728, 1927, 14677, 17, 14921, 9712, 1019, 3]}]}
{"query": {"id": "q_4239", "content": "Tiapride [SEP] Tiapride in levodopa-induced involuntary movements.", "tokenized_content": [2, 22093, 2047, 2261, 3, 22093, 2047, 2261, 1922, 26723, 17, 2719, 28493, 8264, 18, 3]}, "items": [{"id": "p_4239", "content": "Tiapride Hydrochloride [SEP] Benzamide derivative with dopamine antagonist actions similar to SULPIRIDE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22093, 2047, 2261, 16675, 3, 7334, 5482, 10533, 1956, 7964, 8151, 7728, 2551, 1942, 9596, 10984, 20332, 1021, 18, 3]}]}
{"query": {"id": "q_4240", "content": "levodopa [SEP] Tiapride in levodopa-induced involuntary movements.", "tokenized_content": [2, 26723, 3, 22093, 2047, 2261, 1922, 26723, 17, 2719, 28493, 8264, 18, 3]}, "items": [{"id": "p_4240", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4241", "content": "involuntary movements [SEP] Tiapride in levodopa-induced involuntary movements.", "tokenized_content": [2, 28493, 8264, 3, 22093, 2047, 2261, 1922, 26723, 17, 2719, 28493, 8264, 18, 3]}, "items": [{"id": "p_4241", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4242", "content": "Tiapride [SEP] Tiapride, a substituted benzamide derivative closely related to metoclop", "tokenized_content": [2, 22093, 2047, 2261, 3, 22093, 2047, 2261, 16, 43, 11798, 7334, 5482, 10533, 6538, 2712, 1942, 2130, 5406, 2011, 3]}, "items": [{"id": "p_4242", "content": "Tiapride Hydrochloride [SEP] Benzamide derivative with dopamine antagonist actions similar to SULPIRIDE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22093, 2047, 2261, 16675, 3, 7334, 5482, 10533, 1956, 7964, 8151, 7728, 2551, 1942, 9596, 10984, 20332, 1021, 18, 3]}]}
{"query": {"id": "q_4243", "content": "benzamide [SEP] Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-", "tokenized_content": [2, 7334, 5482, 3, 22093, 2047, 2261, 16, 43, 11798, 7334, 5482, 10533, 6538, 2712, 1942, 2130, 5406, 27148, 2261, 16, 3028, 26723, 17, 3]}, "items": [{"id": "p_4243", "content": "benzamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7334, 5482, 3, 3]}]}
{"query": {"id": "q_4244", "content": "metoclopramide [SEP] Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 22093, 2047, 2261, 16, 43, 11798, 7334, 5482, 10533, 6538, 2712, 1942, 2130, 5406, 27148, 2261, 16, 3028, 26723, 17, 2719, 3833, 3253, 28493, 8264, 3]}, "items": [{"id": "p_4244", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_4245", "content": "levodopa [SEP] benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idi", "tokenized_content": [2, 26723, 3, 7334, 5482, 10533, 6538, 2712, 1942, 2130, 5406, 27148, 2261, 16, 3028, 26723, 17, 2719, 3833, 3253, 28493, 8264, 1922, 2641, 2132, 1956, 11407, 3]}, "items": [{"id": "p_4245", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4246", "content": "involuntary movements [SEP] y related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an", "tokenized_content": [2, 28493, 8264, 3, 67, 2712, 1942, 2130, 5406, 27148, 2261, 16, 3028, 26723, 17, 2719, 3833, 3253, 28493, 8264, 1922, 2641, 2132, 1956, 13513, 10124, 11, 61, 2573, 18, 2406, 3]}, "items": [{"id": "p_4246", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4247", "content": "idiopathic Parkinson's disease [SEP] opa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinson", "tokenized_content": [2, 13513, 10124, 11, 61, 2573, 3, 20349, 17, 2719, 3833, 3253, 28493, 8264, 1922, 2641, 2132, 1956, 13513, 10124, 11, 61, 2573, 18, 2406, 16, 1925, 27637, 2760, 1922, 8015, 3]}, "items": [{"id": "p_4247", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4248", "content": "Parkinsonism [SEP] s disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation i", "tokenized_content": [2, 26214, 3, 61, 2573, 18, 2406, 16, 1925, 27637, 2760, 1922, 8015, 2037, 26214, 1956, 18206, 1943, 1927, 2482, 17, 1927, 17, 3253, 26162, 7156, 4866, 1942, 2496, 10975, 51, 3]}, "items": [{"id": "p_4248", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4249", "content": "akinesia [SEP] in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on ", "tokenized_content": [2, 26162, 7156, 3, 1922, 8015, 2037, 26214, 1956, 18206, 1943, 1927, 2482, 17, 1927, 17, 3253, 26162, 7156, 4866, 1942, 2496, 10975, 1922, 2607, 2132, 18, 22093, 2047, 2261, 2430, 3]}, "items": [{"id": "p_4249", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4250", "content": "dystonia [SEP] ect on levodopa-induced early morning of \"off-period\" segmental dystonia. These results fail to support the notion that levodopa-induced", "tokenized_content": [2, 23357, 3, 7495, 1990, 26723, 17, 2719, 3120, 12661, 1927, 6, 4013, 17, 3047, 6, 16294, 23357, 18, 2144, 2274, 3627, 1942, 3373, 1920, 10316, 1988, 26723, 17, 2719, 3]}, "items": [{"id": "p_4250", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_4251", "content": "dyskinesias [SEP]  These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine r", "tokenized_content": [2, 3890, 26682, 1036, 3, 2144, 2274, 3627, 1942, 3373, 1920, 10316, 1988, 26723, 17, 2719, 3890, 26682, 1036, 2032, 4189, 2007, 17774, 18555, 1927, 43, 5850, 2210, 1927, 7964, 60, 3]}, "items": [{"id": "p_4251", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4252", "content": "dopamine [SEP] yskinesias are caused by overstimulation of a separate group of dopamine receptors.", "tokenized_content": [2, 7964, 3, 24018, 26682, 1036, 2032, 4189, 2007, 17774, 18555, 1927, 43, 5850, 2210, 1927, 7964, 4086, 18, 3]}, "items": [{"id": "p_4252", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4253", "content": "epileptic [SEP] Effects of the hippocampal deep brain stimulation on cortical epileptic discharges in penicillin - induced epilepsy model in rats.", "tokenized_content": [2, 16304, 3, 2564, 1927, 1920, 7636, 6515, 3068, 4177, 1990, 5586, 16304, 20805, 1922, 9957, 17, 2719, 9741, 2322, 1922, 3615, 18, 3]}, "items": [{"id": "p_4253", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4254", "content": "penicillin [SEP] mpal deep brain stimulation on cortical epileptic discharges in penicillin - induced epilepsy model in rats.", "tokenized_content": [2, 9957, 3, 12888, 1024, 6515, 3068, 4177, 1990, 5586, 16304, 20805, 1922, 9957, 17, 2719, 9741, 2322, 1922, 3615, 18, 3]}, "items": [{"id": "p_4254", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_4255", "content": "epilepsy [SEP] lation on cortical epileptic discharges in penicillin - induced epilepsy model in rats.", "tokenized_content": [2, 9741, 3, 4144, 2001, 1990, 5586, 16304, 20805, 1922, 9957, 17, 2719, 9741, 2322, 1922, 3615, 18, 3]}, "items": [{"id": "p_4255", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4256", "content": "epileptic [SEP] clinical studies have revealed that hippocampal DBS can control epileptic activity, but the mechanism of action is obscure and optimal st", "tokenized_content": [2, 16304, 3, 2535, 2351, 2162, 3404, 1988, 7636, 14591, 2112, 2285, 16304, 2455, 16, 2308, 1920, 2856, 1927, 4615, 1977, 24245, 1930, 5419, 1955, 3]}, "items": [{"id": "p_4256", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4257", "content": "penicillin [SEP] uency hippocampal stimulation on cortical epileptic activity in penicillin-induced epilepsy model. MATERIAL AND METHODS: Twenty-five Sprag", "tokenized_content": [2, 9957, 3, 63, 2589, 7636, 4177, 1990, 5586, 16304, 2455, 1922, 9957, 17, 2719, 9741, 2322, 18, 3485, 1930, 2860, 30, 7639, 17, 3628, 6039, 2006, 3]}, "items": [{"id": "p_4257", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_4258", "content": "epilepsy [SEP] timulation on cortical epileptic activity in penicillin-induced epilepsy model. MATERIAL AND METHODS: Twenty-five Sprague-Dawley rats we", "tokenized_content": [2, 9741, 3, 2267, 2281, 1990, 5586, 16304, 2455, 1922, 9957, 17, 2719, 9741, 2322, 18, 3485, 1930, 2860, 30, 7639, 17, 3628, 15684, 17, 15798, 3615, 2038, 3]}, "items": [{"id": "p_4258", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4259", "content": "penicillin G [SEP]  DBS was on (185 Hz, 0.5V, 1V, 2V, and 5V for 60 sec) following penicillin G injection intracortically. In the control group hippocampal DBS", "tokenized_content": [2, 9957, 49, 3, 14591, 1982, 1990, 12, 15659, 4865, 16, 20, 18, 25, 1020, 16, 21, 1020, 16, 22, 1020, 16, 1930, 25, 1020, 1958, 3276, 2532, 13, 2894, 9957, 3]}, "items": [{"id": "p_4259", "content": "Penicillin G [SEP] A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. ", "score": 1, "type": null, "tokenized_content": [2, 9957, 49, 3, 43, 9957, 10533, 5384, 2251, 1922, 1920, 2386, 1927, 2496, 5227, 2014, 9057, 16028, 1922, 1920, 2311, 1927, 43, 5386, 1927, 5024, 18, 3]}]}
{"query": {"id": "q_4260", "content": "penicillin-G [SEP] y. EEG recordings were obtained before and 15 minutes following penicillin-G injection, and at 10th minutes following each stimulus for anal", "tokenized_content": [2, 9957, 17, 49, 3, 67, 18, 9052, 9276, 1985, 2926, 3119, 1930, 2461, 4814, 2894, 9957, 17, 49, 4107, 16, 1930, 2019, 20005, 4814, 2894, 2362, 5794, 1958, 2151, 3]}, "items": [{"id": "p_4260", "content": "Penicillin G [SEP] A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. ", "score": 1, "type": null, "tokenized_content": [2, 9957, 49, 3, 43, 9957, 10533, 5384, 2251, 1922, 1920, 2386, 1927, 2496, 5227, 2014, 9057, 16028, 1922, 1920, 2311, 1927, 43, 5386, 1927, 5024, 18, 3]}]}
{"query": {"id": "q_4261", "content": "psychosis [SEP] Neural correlates of S-ketamine induced psychosis during overt continuous verbal fluency.", "tokenized_content": [2, 15489, 3, 5181, 8706, 1927, 61, 17, 14049, 2719, 15489, 2409, 14702, 4798, 10011, 19969, 18, 3]}, "items": [{"id": "p_4261", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_4262", "content": "N-methyl-D-aspartate [SEP] The glutamatergic N-methyl-D-aspartate (NMDA) receptor has been implicated in the pathophysiology of s", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 1920, 16922, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 2258, 2252, 6835, 1922, 1920, 11985, 1927, 61, 3]}, "items": [{"id": "p_4262", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_4263", "content": "NMDA [SEP] The glutamatergic N-methyl-D-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizop", "tokenized_content": [2, 10976, 3, 1920, 16922, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 2258, 2252, 6835, 1922, 1920, 11985, 1927, 7071, 2011, 3]}, "items": [{"id": "p_4263", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_4264", "content": "schizophrenia [SEP] e (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. Administered to healthy volunteers, a subanesthetic dose of th", "tokenized_content": [2, 7899, 3, 47, 12, 10976, 13, 3148, 2258, 2252, 6835, 1922, 1920, 11985, 1927, 7899, 18, 5254, 1942, 4097, 9701, 16, 43, 2316, 4484, 22493, 3253, 1927, 1913, 3]}, "items": [{"id": "p_4264", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_4265", "content": "ketamine [SEP] anesthetic dose of the non-competitive NMDA receptor antagonist ketamine leads to psychopathological symptoms similar to those observed ", "tokenized_content": [2, 14049, 3, 16111, 3253, 1927, 1920, 2447, 17, 10362, 10976, 3148, 8151, 14049, 5029, 1942, 18740, 9112, 2477, 3601, 2551, 1942, 2690, 2528, 3]}, "items": [{"id": "p_4265", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_4266", "content": "glutamatergic dysfunction [SEP] es the core symptoms of illness, supporting the hypothesis of a glutamatergic dysfunction. In a counterbalanced, placebo-controlled, double-blind study d", "tokenized_content": [2, 16922, 5273, 3, 2376, 1920, 4728, 3601, 1927, 6455, 16, 6184, 1920, 4676, 1927, 43, 16922, 5273, 18, 1922, 43, 26964, 16, 5936, 17, 4642, 16, 4825, 17, 7109, 2161, 3]}, "items": [{"id": "p_4266", "content": "Ventricular Dysfunction [SEP] A condition in which HEART VENTRICLES exhibit impaired function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 3, 43, 2625, 1922, 2154, 4003, 21008, 5987, 5761, 2347, 18, 3]}]}
{"query": {"id": "q_4267", "content": "Ketamine [SEP] vert verbal fluency tasks (phonological, lexical and semantic). Ketamine-induced psychopathological symptoms were assessed with the Posi", "tokenized_content": [2, 14049, 3, 3566, 1031, 10011, 19969, 6840, 12, 18726, 16, 18227, 1930, 11933, 13, 18, 14049, 17, 2719, 18740, 9112, 2477, 3601, 1985, 3683, 1956, 1920, 2159, 1033, 3]}, "items": [{"id": "p_4267", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_4268", "content": "psychosis [SEP] Positive and Negative Syndrome Scale (PANSS). Ketamine elicited psychosis like psychopathology. Post-hoc t-tests revealed significant dif", "tokenized_content": [2, 15489, 3, 2843, 1930, 3136, 4741, 3536, 12, 27604, 1036, 13, 18, 14049, 9856, 15489, 3189, 16425, 18, 2753, 17, 8352, 62, 17, 4026, 3404, 2228, 2103, 3]}, "items": [{"id": "p_4268", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_4269", "content": "Dopamine [SEP] Dopamine is not essential for the development of methamphetamine-induced", "tokenized_content": [2, 7964, 3, 7964, 1977, 2084, 4415, 1958, 1920, 2740, 1927, 20375, 17, 2719, 3]}, "items": [{"id": "p_4269", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4270", "content": "methamphetamine [SEP] Dopamine is not essential for the development of methamphetamine-induced neurotoxicity.", "tokenized_content": [2, 20375, 3, 7964, 1977, 2084, 4415, 1958, 1920, 2740, 1927, 20375, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_4270", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_4271", "content": "neurotoxicity [SEP] is not essential for the development of methamphetamine-induced neurotoxicity.", "tokenized_content": [2, 18034, 3, 1977, 2084, 4415, 1958, 1920, 2740, 1927, 20375, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_4271", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4272", "content": "dopamine [SEP] It is widely believed that dopamine (DA) mediates methamphetamine (METH)-induced toxicity to brain ", "tokenized_content": [2, 7964, 3, 2176, 1977, 5673, 9283, 1988, 7964, 12, 3692, 13, 10412, 20375, 12, 2295, 13, 17, 2719, 5532, 1942, 3068, 3]}, "items": [{"id": "p_4272", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4273", "content": "DA [SEP] It is widely believed that dopamine (DA) mediates methamphetamine (METH)-induced toxicity to brain dopa", "tokenized_content": [2, 3692, 3, 2176, 1977, 5673, 9283, 1988, 7964, 12, 3692, 13, 10412, 20375, 12, 2295, 13, 17, 2719, 5532, 1942, 3068, 19428, 3]}, "items": [{"id": "p_4273", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4274", "content": "methamphetamine [SEP] It is widely believed that dopamine (DA) mediates methamphetamine (METH)-induced toxicity to brain dopaminergic neurons, because ", "tokenized_content": [2, 20375, 3, 2176, 1977, 5673, 9283, 1988, 7964, 12, 3692, 13, 10412, 20375, 12, 2295, 13, 17, 2719, 5532, 1942, 3068, 12214, 3558, 16, 2882, 3]}, "items": [{"id": "p_4274", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_4275", "content": "METH [SEP] is widely believed that dopamine (DA) mediates methamphetamine (METH)-induced toxicity to brain dopaminergic neurons, because drugs ", "tokenized_content": [2, 2295, 3, 1977, 5673, 9283, 1988, 7964, 12, 3692, 13, 10412, 20375, 12, 2295, 13, 17, 2719, 5532, 1942, 3068, 12214, 3558, 16, 2882, 4195, 3]}, "items": [{"id": "p_4275", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_4276", "content": "toxicity [SEP] eved that dopamine (DA) mediates methamphetamine (METH)-induced toxicity to brain dopaminergic neurons, because drugs that interfere wit", "tokenized_content": [2, 5532, 3, 2180, 1919, 1988, 7964, 12, 3692, 13, 10412, 20375, 12, 2295, 13, 17, 2719, 5532, 1942, 3068, 12214, 3558, 16, 2882, 4195, 1988, 11827, 16086, 3]}, "items": [{"id": "p_4276", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4277", "content": "L-dihydroxyphenylalanine [SEP] of the data. Here we show that the recently reported ability of L-dihydroxyphenylalanine to reverse the protective effect of alpha-methyl-para-tyrosine ", "tokenized_content": [2, 54, 17, 20684, 17616, 2199, 15769, 3, 1927, 1920, 2230, 18, 3410, 2038, 2146, 1988, 1920, 3998, 2568, 3682, 1927, 54, 17, 20684, 17616, 2199, 15769, 1942, 5267, 1920, 6337, 3]}, "items": [{"id": "p_4277", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4278", "content": "alpha-methyl-para-tyrosine [SEP] of L-dihydroxyphenylalanine to reverse the protective effect of alpha-methyl-para-tyrosine on METH-induced DA neurotoxicity is also confounded by drug eff", "tokenized_content": [2, 4595, 17, 4963, 17, 8202, 17, 6941, 3, 1927, 54, 17, 20684, 17616, 2199, 15769, 1942, 5267, 1920, 6337, 2495, 1927, 4595, 17, 4963, 17, 8202, 17, 6941, 1990, 2295, 3]}, "items": [{"id": "p_4278", "content": "alpha-Methyltyrosine [SEP] An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control ", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 4963, 3145, 20580, 3, 1925, 4106, 1927, 1920, 4113, 6941, 23, 17, 8914, 13966, 16, 1930, 7099, 1927, 1920, 4271, 1927, 25923, 18, 2176, 1977, 2251, 1942, 2285, 3]}]}
{"query": {"id": "q_4279", "content": "neurotoxicity [SEP] tective effect of alpha-methyl-para-tyrosine on METH-induced DA neurotoxicity is also confounded by drug effects on body temperature. Further", "tokenized_content": [2, 18034, 3, 18671, 2185, 2495, 1927, 4595, 17, 4963, 17, 8202, 17, 6941, 1990, 2295, 17, 2719, 3692, 18034, 1977, 2222, 23485, 2007, 2838, 2564, 1990, 3362, 3449, 18, 2520, 3]}, "items": [{"id": "p_4279", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4280", "content": "dopaminergic deficits [SEP] eered to have unilateral brain DA deficits develop METH-induced dopaminergic deficits that are of comparable magnitude on both sides of the brain. Ta", "tokenized_content": [2, 12214, 7961, 3, 11150, 3510, 1942, 2162, 12059, 3068, 3692, 7961, 2392, 2295, 17, 2719, 12214, 7961, 1988, 2032, 1927, 5596, 6453, 1990, 2321, 12868, 1927, 1920, 3068, 18, 4410, 3]}, "items": [{"id": "p_4280", "content": "Neurologic Manifestations [SEP] Clinical signs and symptoms caused by nervous system injury or dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14314, 10952, 3, 2535, 6879, 1930, 3601, 4189, 2007, 7580, 2433, 4047, 2014, 5273, 18, 3]}]}
{"query": {"id": "q_4281", "content": "cocaine [SEP] Brainstem dysgenesis in an infant prenatally exposed to cocaine.", "tokenized_content": [2, 9045, 3, 14938, 3890, 13349, 1922, 1925, 8125, 10907, 1954, 4616, 1942, 9045, 18, 3]}, "items": [{"id": "p_4281", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4282", "content": "cocaine abuse [SEP] Many authors described the effects on the fetus of maternal cocaine abuse during pregnancy. Vasoconstriction appears to be the common mec", "tokenized_content": [2, 9045, 7764, 3, 3086, 3875, 2910, 1920, 2564, 1990, 1920, 15722, 1927, 5509, 9045, 7764, 2409, 5284, 18, 21843, 5107, 1942, 1998, 1920, 3059, 10685, 3]}, "items": [{"id": "p_4282", "content": "Cocaine-Related Disorders [SEP] Disorders related or resulting from use of cocaine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9045, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 9045, 18, 3]}]}
{"query": {"id": "q_4283", "content": "fetal anomalies [SEP] to be the common mechanism of action leading to a wide range of fetal anomalies. We report on an infant with multiple cranial-nerve involvement", "tokenized_content": [2, 5944, 13621, 3, 1942, 1998, 1920, 3059, 2856, 1927, 4615, 4523, 1942, 43, 4743, 3109, 1927, 5944, 13621, 18, 2038, 3809, 1990, 1925, 8125, 1956, 3137, 13598, 17, 5507, 5668, 3]}, "items": [{"id": "p_4283", "content": "Fetal Diseases [SEP] Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5944, 3902, 3, 15421, 2961, 1927, 1920, 15722, 1922, 1920, 16297, 18, 2673, 5944, 3902, 2278, 1998, 2868, 1956, 5944, 6565, 18, 3]}]}
{"query": {"id": "q_4284", "content": "multiple cranial-nerve involvement [SEP] to a wide range of fetal anomalies. We report on an infant with multiple cranial-nerve involvement attributable to brainstem dysgenesis, born to a cocaine-addicte", "tokenized_content": [2, 3137, 13598, 17, 5507, 5668, 3, 1942, 43, 4743, 3109, 1927, 5944, 13621, 18, 2038, 3809, 1990, 1925, 8125, 1956, 3137, 13598, 17, 5507, 5668, 11081, 1942, 14938, 3890, 13349, 3]}, "items": [{"id": "p_4284", "content": "Cranial Nerve Diseases [SEP] Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disor", "score": 1, "type": null, "tokenized_content": [2, 13598, 5507, 3902, 3, 4414, 1927, 2340, 2014, 2253, 1927, 1920, 12367, 13598, 12014, 18, 1956, 1920, 7541, 1927, 1920, 10109, 1930, 11284, 12014, 16, 2052, 5921, 2054, 1924, 3]}]}
{"query": {"id": "q_4285", "content": "cocaine-addicted [SEP] rve involvement attributable to brainstem dysgenesis, born to a cocaine-addicted mother.", "tokenized_content": [2, 9045, 17, 16888, 2013, 3, 8309, 1021, 5668, 11081, 1942, 14938, 3890, 13349, 16, 8813, 1942, 43, 9045, 17, 16888, 2013, 7999, 18, 3]}, "items": [{"id": "p_4285", "content": "Cocaine-Related Disorders [SEP] Disorders related or resulting from use of cocaine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9045, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 9045, 18, 3]}]}
{"query": {"id": "q_4286", "content": "streptozotocin [SEP] The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.", "tokenized_content": [2, 26492, 3, 1920, 6337, 2770, 1927, 10933, 1922, 26492, 17, 2719, 6152, 15582, 18, 3]}, "items": [{"id": "p_4286", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_4287", "content": "diabetic nephropathy [SEP] The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.", "tokenized_content": [2, 6152, 15582, 3, 1920, 6337, 2770, 1927, 10933, 1922, 26492, 17, 2719, 6152, 15582, 18, 3]}, "items": [{"id": "p_4287", "content": "Diabetic Nephropathies [SEP] KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstit", "score": 1, "type": null, "tokenized_content": [2, 6152, 7737, 7262, 2062, 3, 5245, 8209, 2458, 1956, 4032, 9695, 1930, 7359, 5245, 19268, 1957, 31, 24332, 31, 5245, 14876, 31, 1930, 1920, 10918, 1031, 3]}]}
{"query": {"id": "q_4288", "content": "Diabetic nephropathy [SEP] OBJECTIVE: Diabetic nephropathy is one of the major causes of renal failure, which is accompani", "tokenized_content": [2, 6152, 15582, 3, 4470, 30, 6152, 15582, 1977, 2340, 1927, 1920, 3044, 5092, 1927, 4604, 4574, 16, 2154, 1977, 6949, 1033, 3]}, "items": [{"id": "p_4288", "content": "Diabetic Nephropathies [SEP] KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstit", "score": 1, "type": null, "tokenized_content": [2, 6152, 7737, 7262, 2062, 3, 5245, 8209, 2458, 1956, 4032, 9695, 1930, 7359, 5245, 19268, 1957, 31, 24332, 31, 5245, 14876, 31, 1930, 1920, 10918, 1031, 3]}]}
{"query": {"id": "q_4289", "content": "renal failure [SEP] OBJECTIVE: Diabetic nephropathy is one of the major causes of renal failure, which is accompanied by the production of reactive oxygen spec", "tokenized_content": [2, 4604, 4574, 3, 4470, 30, 6152, 15582, 1977, 2340, 1927, 1920, 3044, 5092, 1927, 4604, 4574, 16, 2154, 1977, 7936, 2007, 1920, 3372, 1927, 6079, 4612, 2187, 3]}, "items": [{"id": "p_4289", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4290", "content": "oxygen [SEP] nal failure, which is accompanied by the production of reactive oxygen species (ROS). Nrf2 is the primary transcription factor that co", "tokenized_content": [2, 4612, 3, 13120, 4574, 16, 2154, 1977, 7936, 2007, 1920, 3372, 1927, 6079, 4612, 3038, 12, 4742, 13, 18, 10933, 1977, 1920, 3065, 3213, 2991, 1988, 2081, 3]}, "items": [{"id": "p_4290", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_4291", "content": "diabetic nephropathy [SEP] rt our findings demonstrating a protective role of Nrf2 against diabetic nephropathy. RESEARCH DESIGN AND METHODS: We explore the protective role of", "tokenized_content": [2, 6152, 15582, 3, 4341, 2342, 3056, 7530, 43, 6337, 2770, 1927, 10933, 3316, 6152, 15582, 18, 2659, 3036, 1930, 2860, 30, 2038, 6414, 1920, 6337, 2770, 1927, 3]}, "items": [{"id": "p_4291", "content": "Diabetic Nephropathies [SEP] KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstit", "score": 1, "type": null, "tokenized_content": [2, 6152, 7737, 7262, 2062, 3, 5245, 8209, 2458, 1956, 4032, 9695, 1930, 7359, 5245, 19268, 1957, 31, 24332, 31, 5245, 14876, 31, 1930, 1920, 10918, 1031, 3]}]}
{"query": {"id": "q_4292", "content": "streptozotocin [SEP] man kidney biopsy tissues from diabetic nephropathy patients, a streptozotocin-induced diabetic nephropathy model in Nrf2(-/-) mice, and cultu", "tokenized_content": [2, 26492, 3, 2323, 5245, 6831, 3878, 2037, 6152, 15582, 2132, 16, 43, 26492, 17, 2719, 6152, 15582, 2322, 1922, 10933, 12, 17, 19, 17, 13, 2518, 16, 1930, 2871, 1032, 3]}, "items": [{"id": "p_4292", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_4293", "content": "renal damage [SEP] monstrated to be crucial in ameliorating streptozotocin-induced renal damage. This is evident by Nrf2(-/-) mice having higher ROS production", "tokenized_content": [2, 4604, 4293, 3, 28254, 25957, 1942, 1998, 6608, 1922, 11963, 2287, 26492, 17, 2719, 4604, 4293, 18, 2052, 1977, 7501, 2007, 10933, 12, 17, 19, 17, 13, 2518, 4537, 2580, 3]}, "items": [{"id": "p_4293", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_4294", "content": "renal injury [SEP]  production and suffering from greater oxidative DNA damage and renal injury compared with Nrf2(+/+) mice. Mechanistic studies in both in vi", "tokenized_content": [2, 4604, 4047, 3, 3372, 1930, 11364, 2037, 3430, 5163, 2678, 4293, 1930, 4604, 4047, 2452, 1956, 10933, 12, 15, 19, 15, 13, 2518, 18, 10640, 2351, 1922, 2321, 1922, 3070, 3]}, "items": [{"id": "p_4294", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_4295", "content": "glucose [SEP] ellular matrix production. In human renal mesangial cells, high glucose induced ROS production and activated expression of Nrf2 and its", "tokenized_content": [2, 3817, 3, 20430, 2168, 4526, 3372, 18, 1922, 2616, 4604, 24310, 2094, 16, 2149, 3817, 2719, 4742, 3372, 1930, 4128, 2294, 1927, 10933, 1930, 2496, 3]}, "items": [{"id": "p_4295", "content": "Glucose [SEP] A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in i", "score": 1, "type": null, "tokenized_content": [2, 3817, 3, 43, 3065, 4585, 1927, 3844, 1958, 5818, 7373, 18, 2176, 1977, 10414, 6966, 1930, 1977, 2435, 1922, 12953, 1930, 2303, 7516, 1927, 4793, 1922, 51, 3]}]}
{"query": {"id": "q_4296", "content": "tranexamic Acid [SEP] High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac sur", "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 2149, 17, 3253, 29808, 2783, 13514, 2687, 1977, 2458, 1956, 2447, 21171, 4197, 2535, 10060, 1922, 4435, 2250, 3]}, "items": [{"id": "p_4296", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_4297", "content": "seizures [SEP] gh-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.", "tokenized_content": [2, 10060, 3, 6101, 17, 3253, 29808, 2783, 13514, 2687, 1977, 2458, 1956, 2447, 21171, 4197, 2535, 10060, 1922, 4435, 4548, 2132, 18, 3]}, "items": [{"id": "p_4297", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4298", "content": "convulsive [SEP] e observed a notable increase in the incidence of postoperative convulsive seizures from 1.3% to 3.8% in patients having undergone major c", "tokenized_content": [2, 4772, 13042, 3, 47, 2528, 43, 11892, 2760, 1922, 1920, 4332, 1927, 5924, 4772, 13042, 10060, 2037, 21, 18, 23, 9, 1942, 23, 18, 28, 9, 1922, 2132, 4537, 12299, 3]}, "items": [{"id": "p_4298", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4299", "content": "seizures [SEP] a notable increase in the incidence of postoperative convulsive seizures from 1.3% to 3.8% in patients having undergone major cardiac su", "tokenized_content": [2, 10060, 3, 43, 11892, 2760, 1922, 1920, 4332, 1927, 5924, 4772, 13042, 10060, 2037, 21, 18, 23, 9, 1942, 23, 18, 28, 9, 1922, 2132, 4537, 12299, 3044, 4435, 2020, 3]}, "items": [{"id": "p_4299", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4300", "content": "tranexamic acid [SEP] ts were temporally coincident with the initial use of high-dose tranexamic acid (TXA) therapy after withdrawal of aprotinin from general clinic", "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 4894, 1985, 17579, 22829, 1956, 1920, 3754, 2485, 1927, 2149, 17, 3253, 29808, 2783, 13514, 2687, 12, 10117, 1019, 13, 3181, 2256, 9594, 1927, 25886, 3]}, "items": [{"id": "p_4300", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_4301", "content": "TXA [SEP] y coincident with the initial use of high-dose tranexamic acid (TXA) therapy after withdrawal of aprotinin from general clinical us", "tokenized_content": [2, 10117, 1019, 3, 67, 22829, 1956, 1920, 3754, 2485, 1927, 2149, 17, 3253, 29808, 2783, 13514, 2687, 12, 10117, 1019, 13, 3181, 2256, 9594, 1927, 25886, 2037, 3335, 2535, 2022, 3]}, "items": [{"id": "p_4301", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_4302", "content": "cerebral ischemic injury [SEP] LTS: Twenty-one of the 24 patients did not have evidence of new cerebral ischemic injury, but seizures were likely due to ischemic brain injury in 3 pat", "tokenized_content": [2, 6329, 7427, 4047, 3, 3457, 1036, 30, 7639, 17, 2340, 1927, 1920, 2686, 2132, 2811, 2084, 2162, 3095, 1927, 2814, 6329, 7427, 4047, 16, 2308, 10060, 1985, 3205, 2810, 1942, 3]}, "items": [{"id": "p_4302", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_4303", "content": "ischemic brain injury [SEP] f new cerebral ischemic injury, but seizures were likely due to ischemic brain injury in 3 patients. All patients with seizures did not have permanen", "tokenized_content": [2, 7427, 3068, 4047, 3, 48, 2814, 6329, 7427, 4047, 16, 2308, 10060, 1985, 3205, 2810, 1942, 7427, 3068, 4047, 1922, 23, 2132, 18, 2136, 2132, 1956, 10060, 2811, 2084, 2162, 3]}, "items": [{"id": "p_4303", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_4304", "content": "neurological abnormalities [SEP] n 3 patients. All patients with seizures did not have permanent neurological abnormalities. All 24 patients with seizures received high doses of TXA intra", "tokenized_content": [2, 7605, 6754, 3, 56, 23, 2132, 18, 2136, 2132, 1956, 10060, 2811, 2084, 2162, 11047, 7605, 6754, 18, 2136, 2686, 2132, 1956, 10060, 4004, 2149, 5312, 1927, 10117, 1019, 5153, 3]}, "items": [{"id": "p_4304", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4305", "content": "brain ischemic [SEP] tient were managed using cardiopulmonary bypass. No evidence of brain ischemic, metabolic, or hyperthermia-induced causes for their seizures w", "tokenized_content": [2, 3068, 7427, 3, 19108, 4905, 1985, 11155, 2193, 17749, 10344, 18, 2239, 3095, 1927, 3068, 7427, 16, 4487, 16, 2014, 21945, 17, 2719, 5092, 1958, 2310, 10060, 65, 3]}, "items": [{"id": "p_4305", "content": "Ischemic Attack, Transient [SEP] Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and", "score": 1, "type": null, "tokenized_content": [2, 7427, 8926, 16, 6809, 3, 5310, 10743, 9232, 1927, 8083, 16, 9341, 12766, 13042, 7427, 5273, 1927, 1920, 3068, 4537, 43, 4392, 1927, 2941, 2254, 2686, 3967, 16, 1930, 3]}]}
{"query": {"id": "q_4306", "content": "hyperthermia [SEP] opulmonary bypass. No evidence of brain ischemic, metabolic, or hyperthermia-induced causes for their seizures was apparent. CONCLUSION: Our", "tokenized_content": [2, 21945, 3, 2494, 13897, 10344, 18, 2239, 3095, 1927, 3068, 7427, 16, 4487, 16, 2014, 21945, 17, 2719, 5092, 1958, 2310, 10060, 1982, 6273, 18, 4180, 30, 2342, 3]}, "items": [{"id": "p_4306", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_4307", "content": "dysosmia [SEP] Recurrent dysosmia induced by pyrazinamide.", "tokenized_content": [2, 3890, 17096, 2126, 3, 7457, 3890, 17096, 2126, 2719, 2007, 6487, 25823, 5482, 18, 3]}, "items": [{"id": "p_4307", "content": "Olfaction Disorders [SEP] Loss of or impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATOR", "score": 1, "type": null, "tokenized_content": [2, 2865, 18137, 4414, 3, 3257, 1927, 2014, 5761, 3682, 1942, 2426, 1992, 18, 2052, 2278, 1998, 4189, 2007, 11284, 5507, 3902, 31, 26124, 14046, 9414, 3902, 31, 4324, 4962, 3061, 3]}]}
{"query": {"id": "q_4308", "content": "pyrazinamide [SEP] Recurrent dysosmia induced by pyrazinamide.", "tokenized_content": [2, 6487, 25823, 5482, 3, 7457, 3890, 17096, 2126, 2719, 2007, 6487, 25823, 5482, 18, 3]}, "items": [{"id": "p_4308", "content": "Pyrazinamide [SEP] A pyrazine that is used therapeutically as an antitubercular agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6487, 25823, 5482, 3, 43, 6487, 10119, 1988, 1977, 2251, 25058, 1966, 1925, 10310, 29603, 2168, 5899, 18, 3]}]}
{"query": {"id": "q_4309", "content": "Pyrazinamide [SEP] Pyrazinamide can have adverse effects such as hepatic toxicity, hyperuricemi", "tokenized_content": [2, 6487, 25823, 5482, 3, 6487, 25823, 5482, 2112, 2162, 5246, 2564, 2427, 1966, 6095, 5532, 16, 4194, 15861, 1987, 1033, 3]}, "items": [{"id": "p_4309", "content": "Pyrazinamide [SEP] A pyrazine that is used therapeutically as an antitubercular agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6487, 25823, 5482, 3, 43, 6487, 10119, 1988, 1977, 2251, 25058, 1966, 1925, 10310, 29603, 2168, 5899, 18, 3]}]}
{"query": {"id": "q_4310", "content": "hepatic toxicity [SEP] Pyrazinamide can have adverse effects such as hepatic toxicity, hyperuricemia or digestive disorders. In rare cases, alteratio", "tokenized_content": [2, 6095, 5532, 3, 6487, 25823, 5482, 2112, 2162, 5246, 2564, 2427, 1966, 6095, 5532, 16, 4194, 15861, 3847, 2014, 15486, 4414, 18, 1922, 5844, 2919, 16, 4238, 1968, 1037, 3]}, "items": [{"id": "p_4310", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4311", "content": "hyperuricemia [SEP] Pyrazinamide can have adverse effects such as hepatic toxicity, hyperuricemia or digestive disorders. In rare cases, alterations in taste and", "tokenized_content": [2, 4194, 15861, 3847, 3, 6487, 25823, 5482, 2112, 2162, 5246, 2564, 2427, 1966, 6095, 5532, 16, 4194, 15861, 3847, 2014, 15486, 4414, 18, 1922, 5844, 2919, 16, 5996, 1922, 13891, 3]}, "items": [{"id": "p_4311", "content": "Hyperuricemia [SEP] Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7", "score": 1, "type": null, "tokenized_content": [2, 4194, 15861, 3847, 3, 9122, 17607, 2687, 2014, 3674, 2010, 1922, 2877, 1966, 3608, 2007, 2496, 12506, 1922, 3582, 2019, 3191, 6429, 45, 31, 3430, 2254, 20, 18, 3858, 7445, 1945, 2079, 4154, 12, 27, 3]}]}
{"query": {"id": "q_4312", "content": "pyrazinamide [SEP]  alterations in taste and smell function have been reported for pyrazinamide when combined with other drugs. We report a case of reversible ", "tokenized_content": [2, 6487, 25823, 5482, 3, 5996, 1922, 13891, 1930, 2426, 1992, 2347, 2162, 2252, 2568, 1958, 6487, 25823, 5482, 2469, 4252, 1956, 2303, 4195, 18, 2038, 3809, 43, 3087, 1927, 10743, 3]}, "items": [{"id": "p_4312", "content": "Pyrazinamide [SEP] A pyrazine that is used therapeutically as an antitubercular agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6487, 25823, 5482, 3, 43, 6487, 10119, 1988, 1977, 2251, 25058, 1966, 1925, 10310, 29603, 2168, 5899, 18, 3]}]}
{"query": {"id": "q_4313", "content": "olfactory disorder [SEP]  when combined with other drugs. We report a case of reversible olfactory disorder related to pyrazinamide in a woman, with a positive rechallenge", "tokenized_content": [2, 11284, 4770, 3, 2469, 4252, 1956, 2303, 4195, 18, 2038, 3809, 43, 3087, 1927, 10743, 11284, 4770, 2712, 1942, 6487, 25823, 5482, 1922, 43, 10440, 16, 1956, 43, 2843, 27317, 3]}, "items": [{"id": "p_4313", "content": "Olfaction Disorders [SEP] Loss of or impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATOR", "score": 1, "type": null, "tokenized_content": [2, 2865, 18137, 4414, 3, 3257, 1927, 2014, 5761, 3682, 1942, 2426, 1992, 18, 2052, 2278, 1998, 4189, 2007, 11284, 5507, 3902, 31, 26124, 14046, 9414, 3902, 31, 4324, 4962, 3061, 3]}]}
{"query": {"id": "q_4314", "content": "Dysosmia [SEP] nsation of smelling something burning 15 min after drug intake. Dysosmia disappeared completely after pyrazinamide withdrawal and recurr", "tokenized_content": [2, 3890, 17096, 2126, 3, 4246, 1943, 1927, 2426, 5644, 15126, 22873, 2461, 2360, 2256, 2838, 5240, 18, 3890, 17096, 2126, 15588, 5796, 2256, 6487, 25823, 5482, 9594, 1930, 4734, 3]}, "items": [{"id": "p_4314", "content": "Olfaction Disorders [SEP] Loss of or impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATOR", "score": 1, "type": null, "tokenized_content": [2, 2865, 18137, 4414, 3, 3257, 1927, 2014, 5761, 3682, 1942, 2426, 1992, 18, 2052, 2278, 1998, 4189, 2007, 11284, 5507, 3902, 31, 26124, 14046, 9414, 3902, 31, 4324, 4962, 3061, 3]}]}
{"query": {"id": "q_4315", "content": "difluoromethylornithine [SEP] t of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.", "tokenized_content": [2, 23426, 18403, 5578, 1953, 2053, 3, 62, 1927, 4433, 12382, 18609, 28218, 1922, 43, 3193, 4337, 2535, 3046, 1927, 23426, 18403, 5578, 1953, 2053, 1930, 9596, 2762, 1948, 1958, 5455, 3]}, "items": [{"id": "p_4315", "content": "Eflornithine [SEP] An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8485, 4051, 8635, 22523, 2912, 3, 1925, 4106, 1927, 26918, 23922, 16, 1920, 2769, 8051, 4113, 1927, 1920, 27883, 14041, 3374, 18, 3]}]}
{"query": {"id": "q_4316", "content": "sulindac [SEP] ms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.", "tokenized_content": [2, 9596, 2762, 1948, 3, 3012, 1922, 43, 3193, 4337, 2535, 3046, 1927, 23426, 18403, 5578, 1953, 2053, 1930, 9596, 2762, 1948, 1958, 5455, 1927, 13088, 7820, 16787, 18, 3]}, "items": [{"id": "p_4316", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_4317", "content": "colorectal adenomas [SEP] difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.", "tokenized_content": [2, 7820, 16787, 3, 23426, 18403, 5578, 1953, 2053, 1930, 9596, 2762, 1948, 1958, 5455, 1927, 13088, 7820, 16787, 18, 3]}, "items": [{"id": "p_4317", "content": "Colorectal Neoplasms [SEP] Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMI", "score": 1, "type": null, "tokenized_content": [2, 7820, 15347, 3, 3861, 2014, 2539, 1927, 1920, 4120, 2014, 1920, 19773, 2014, 2321, 18, 2565, 2790, 1958, 7820, 2539, 3951, 3724, 20428, 12087, 31, 3011, 1033, 3]}]}
{"query": {"id": "q_4318", "content": "adenomatous polyps [SEP] A phase III clinical trial assessed the recurrence of adenomatous polyps after treatment for 36 months with difluoromethylornithine (DFM", "tokenized_content": [2, 30390, 17410, 3, 43, 3193, 4337, 2535, 3046, 3683, 1920, 6339, 1927, 30390, 17410, 2256, 2311, 1958, 3480, 3221, 1956, 23426, 18403, 5578, 1953, 2053, 12, 8122, 1035, 3]}, "items": [{"id": "p_4318", "content": "Adenomatous Polyps [SEP] Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 30390, 17410, 3, 8867, 15347, 3595, 2037, 21808, 8081, 18, 12, 2037, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4319", "content": "difluoromethylornithine [SEP] rrence of adenomatous polyps after treatment for 36 months with difluoromethylornithine (DFMO) plus sulindac or matched placebos. Temporary hearing los", "tokenized_content": [2, 23426, 18403, 5578, 1953, 2053, 3, 5162, 2055, 1927, 30390, 17410, 2256, 2311, 1958, 3480, 3221, 1956, 23426, 18403, 5578, 1953, 2053, 12, 8122, 12492, 13, 5390, 9596, 2762, 1948, 3]}, "items": [{"id": "p_4319", "content": "Eflornithine [SEP] An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8485, 4051, 8635, 22523, 2912, 3, 1925, 4106, 1927, 26918, 23922, 16, 1920, 2769, 8051, 4113, 1927, 1920, 27883, 14041, 3374, 18, 3]}]}
{"query": {"id": "q_4320", "content": "DFMO [SEP] yps after treatment for 36 months with difluoromethylornithine (DFMO) plus sulindac or matched placebos. Temporary hearing loss is a", "tokenized_content": [2, 8122, 12492, 3, 21995, 1036, 2256, 2311, 1958, 3480, 3221, 1956, 23426, 18403, 5578, 1953, 2053, 12, 8122, 12492, 13, 5390, 9596, 2762, 1948, 2014, 5992, 5936, 1036, 18, 15301, 3]}, "items": [{"id": "p_4320", "content": "Eflornithine [SEP] An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8485, 4051, 8635, 22523, 2912, 3, 1925, 4106, 1927, 26918, 23922, 16, 1920, 2769, 8051, 4113, 1927, 1920, 27883, 14041, 3374, 18, 3]}]}
{"query": {"id": "q_4321", "content": "sulindac [SEP] reatment for 36 months with difluoromethylornithine (DFMO) plus sulindac or matched placebos. Temporary hearing loss is a known toxicity", "tokenized_content": [2, 9596, 2762, 1948, 3, 1964, 7647, 1958, 3480, 3221, 1956, 23426, 18403, 5578, 1953, 2053, 12, 8122, 12492, 13, 5390, 9596, 2762, 1948, 2014, 5992, 5936, 1036, 18, 15301, 8512, 3]}, "items": [{"id": "p_4321", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_4322", "content": "hearing loss [SEP] ylornithine (DFMO) plus sulindac or matched placebos. Temporary hearing loss is a known toxicity of treatment with DFMO, thus a comprehensiv", "tokenized_content": [2, 8512, 3257, 3, 12111, 5578, 1953, 2053, 12, 8122, 12492, 13, 5390, 9596, 2762, 1948, 2014, 5992, 5936, 1036, 18, 15301, 8512, 3257, 1977, 43, 3171, 5532, 1927, 2311, 1956, 3]}, "items": [{"id": "p_4322", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_4323", "content": "toxicity [SEP] sulindac or matched placebos. Temporary hearing loss is a known toxicity of treatment with DFMO, thus a comprehensive approach was devel", "tokenized_content": [2, 5532, 3, 9596, 2762, 1948, 2014, 5992, 5936, 1036, 18, 15301, 8512, 3257, 1977, 43, 3171, 5532, 1927, 2311, 1956, 8122, 12492, 16, 2842, 43, 6911, 2998, 1982, 4251, 1938, 3]}, "items": [{"id": "p_4323", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4324", "content": "ototoxicity [SEP] ared with the placebo group. The estimated attributable risk of ototoxicity from exposure to the drug is 8.4% (95% confidence interval, -2.", "tokenized_content": [2, 7608, 11930, 3, 2032, 1007, 1956, 1920, 5936, 2210, 18, 1920, 4185, 11081, 2565, 1927, 7608, 11930, 2037, 3395, 1942, 1920, 2838, 1977, 28, 18, 24, 9, 12, 3002, 9, 3]}, "items": [{"id": "p_4324", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_4325", "content": "mental slowing [SEP] Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl ", "tokenized_content": [2, 5018, 20025, 3, 2502, 5018, 20025, 2458, 1956, 1920, 10290, 22206, 1006, 5465, 2256, 5083, 17797, 11397, 28131, 14458, 1024, 3]}, "items": [{"id": "p_4325", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_4326", "content": "trihexyphenidyl [SEP] d mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly.", "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 46, 5018, 20025, 2458, 1956, 1920, 10290, 22206, 1006, 5465, 2256, 5083, 17797, 11397, 28131, 14458, 1024, 4726, 5851, 12074, 12745, 6013, 1922, 3]}, "items": [{"id": "p_4326", "content": "Trihexyphenidyl [SEP] One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2340, 1927, 1920, 20424, 8290, 20318, 10515, 2251, 1958, 2311, 1927, 10124, 3122, 4414, 1930, 2838, 17, 2719, 21346, 3553, 25238, 1923, 3]}]}
{"query": {"id": "q_4327", "content": "trihexyphenidyl [SEP] he relationship between APOE epsilon4 and subjective effects of trihexyphenidyl on measures reflecting sedation and confusion and to investigat", "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2234, 3303, 2192, 10290, 22206, 1006, 1930, 9106, 2564, 1927, 5083, 17797, 11397, 28131, 14458, 1024, 1990, 3975, 10243, 15263, 1930, 18272, 1930, 3]}, "items": [{"id": "p_4327", "content": "Trihexyphenidyl [SEP] One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2340, 1927, 1920, 20424, 8290, 20318, 10515, 2251, 1958, 2311, 1927, 10124, 3122, 4414, 1930, 2838, 17, 2719, 21346, 3553, 25238, 1923, 3]}]}
{"query": {"id": "q_4328", "content": "confusion [SEP]  effects of trihexyphenidyl on measures reflecting sedation and confusion and to investigate the relationship between trihexyphenidyl-ind", "tokenized_content": [2, 18272, 3, 2564, 1927, 5083, 17797, 11397, 28131, 14458, 1024, 1990, 3975, 10243, 15263, 1930, 18272, 1930, 1942, 4482, 1920, 3303, 2192, 5083, 17797, 11397, 28131, 14458, 1024, 17, 2063, 3]}, "items": [{"id": "p_4328", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_4329", "content": "mental slowness [SEP]  of trihexyphenidyl resulted in increased subjective ratings of mental slowness in carriers of the APOE epsilon4 allele only. Drug effects as d", "tokenized_content": [2, 5018, 5470, 2971, 3, 1927, 5083, 17797, 11397, 28131, 14458, 1024, 4306, 1922, 2502, 9106, 10158, 1927, 5018, 5470, 2971, 1922, 8974, 1927, 1920, 10290, 22206, 1006, 5465, 2444, 18, 3]}, "items": [{"id": "p_4329", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_4330", "content": "mental slowing [SEP] ele in healthy elderly was associated with increased subjective mental slowing after trihexyphenidyl anticholinergic challenge.", "tokenized_content": [2, 5018, 20025, 3, 3064, 1922, 4097, 7354, 1982, 2458, 1956, 2502, 9106, 5018, 20025, 2256, 5083, 17797, 11397, 28131, 14458, 1024, 5851, 12074, 12745, 6013, 18, 3]}, "items": [{"id": "p_4330", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_4331", "content": "steroid [SEP] Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin.", "tokenized_content": [2, 9507, 3, 5343, 2564, 1927, 20475, 23219, 10817, 1935, 9507, 3395, 1922, 4005, 3615, 1956, 2330, 11153, 18, 3]}, "items": [{"id": "p_4331", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4332", "content": "serotonin [SEP] rtal anabolic androgenic steroid exposure in male rats with low serotonin.", "tokenized_content": [2, 11153, 3, 25551, 1024, 23219, 10817, 1935, 9507, 3395, 1922, 4005, 3615, 1956, 2330, 11153, 18, 3]}, "items": [{"id": "p_4332", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4333", "content": "steroid [SEP] o assess the interactive effects of chronic anabolic androgenic steroid (AAS) exposure and brain serotonin (5-hydroxytryptamine, 5-HT) ", "tokenized_content": [2, 9507, 3, 57, 2634, 1920, 13974, 2564, 1927, 3724, 23219, 10817, 1935, 9507, 12, 20354, 13, 3395, 1930, 3068, 11153, 12, 25, 17, 8275, 30298, 3812, 16, 25, 17, 5334, 3]}, "items": [{"id": "p_4333", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4334", "content": "serotonin [SEP] of chronic anabolic androgenic steroid (AAS) exposure and brain serotonin (5-hydroxytryptamine, 5-HT) depletion on behavior of pubertal m", "tokenized_content": [2, 11153, 3, 1927, 3724, 23219, 10817, 1935, 9507, 12, 20354, 13, 3395, 1930, 3068, 11153, 12, 25, 17, 8275, 30298, 3812, 16, 25, 17, 5334, 13, 6882, 1990, 3379, 1927, 3]}, "items": [{"id": "p_4334", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4335", "content": "5-hydroxytryptamine [SEP] anabolic androgenic steroid (AAS) exposure and brain serotonin (5-hydroxytryptamine, 5-HT) depletion on behavior of pubertal male rats. Serotonin w", "tokenized_content": [2, 25, 17, 8275, 30298, 3812, 3, 23219, 10817, 1935, 9507, 12, 20354, 13, 3395, 1930, 3068, 11153, 12, 25, 17, 8275, 30298, 3812, 16, 25, 17, 5334, 13, 6882, 1990, 3]}, "items": [{"id": "p_4335", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4336", "content": "5-HT [SEP] teroid (AAS) exposure and brain serotonin (5-hydroxytryptamine, 5-HT) depletion on behavior of pubertal male rats. Serotonin was dep", "tokenized_content": [2, 25, 17, 5334, 3, 6005, 2642, 12, 20354, 13, 3395, 1930, 3068, 11153, 12, 25, 17, 8275, 30298, 3812, 16, 25, 17, 5334, 13, 6882, 1990, 3379, 1927, 20475, 4005, 3]}, "items": [{"id": "p_4336", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4337", "content": "Serotonin [SEP] ytryptamine, 5-HT) depletion on behavior of pubertal male rats. Serotonin was depleted beginning on postnatal day 26 with parachloropheny", "tokenized_content": [2, 11153, 3, 24412, 6907, 25958, 25157, 16, 25, 17, 5334, 13, 6882, 1990, 3379, 1927, 20475, 4005, 3615, 18, 11153, 1982, 9462, 7828, 1990, 9992, 3007, 3179, 1956, 13344, 7806, 3]}, "items": [{"id": "p_4337", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4338", "content": "testosterone [SEP] ated rats and half the saline-treated rats began treatment with testosterone (T, 5 mg/kg, 5 days/week). Behavioral measures included locomot", "tokenized_content": [2, 10592, 3, 30280, 1007, 3615, 1930, 4768, 1920, 5977, 17, 2868, 3615, 10486, 2311, 1956, 10592, 12, 62, 16, 25, 2786, 19, 3621, 16, 25, 3000, 19, 2982, 13, 18, 3]}, "items": [{"id": "p_4338", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_4339", "content": "T [SEP] The goal of this study was to assess the interactive effects of c", "tokenized_content": [2, 62, 3, 1920, 6640, 1927, 2052, 2161, 1982, 1942, 2634, 1920, 13974, 2564, 1927, 45, 3]}, "items": [{"id": "p_4339", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_4340", "content": "irritability [SEP] 5 mg/kg, 5 days/week). Behavioral measures included locomotion, irritability, copulation, partner preference, and aggression. Animals were t", "tokenized_content": [2, 29534, 3, 25, 2786, 19, 3621, 16, 25, 3000, 19, 2982, 13, 18, 5343, 3975, 3063, 16929, 16, 29534, 16, 3725, 2281, 16, 8240, 8308, 16, 1930, 13116, 18, 3555, 3]}, "items": [{"id": "p_4340", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4341", "content": "aggression [SEP] d locomotion, irritability, copulation, partner preference, and aggression. Animals were tested for aggression in their home cage, both wi", "tokenized_content": [2, 13116, 3, 46, 16929, 16, 29534, 16, 3725, 2281, 16, 8240, 8308, 16, 1930, 13116, 18, 3555, 1985, 3620, 1958, 13116, 1922, 2310, 4502, 12562, 16, 2321, 11980, 3]}, "items": [{"id": "p_4341", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4342", "content": "5-hydroxyindoleacetic acid [SEP] ion (mild tail pinch). Brain levels of 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), were determined using HPLC. PCPA significantly and su", "tokenized_content": [2, 25, 17, 8275, 19554, 13722, 2687, 3, 4755, 12, 5809, 5281, 8701, 2072, 13, 18, 3068, 2428, 1927, 25, 17, 5334, 1930, 2496, 9483, 16, 25, 17, 8275, 19554, 13722, 3]}, "items": [{"id": "p_4342", "content": "Hydroxyindoleacetic Acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8275, 19554, 13722, 2687, 3, 3]}]}
{"query": {"id": "q_4343", "content": "5-HIAA [SEP]  levels of 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), were determined using HPLC. PCPA significantly and substantia", "tokenized_content": [2, 25, 17, 10220, 5025, 3, 2428, 1927, 25, 17, 5334, 1930, 2496, 9483, 16, 25, 17, 8275, 19554, 13722, 2687, 12, 25, 17, 10220, 5025, 13, 16, 1985, 3180, 2193, 3]}, "items": [{"id": "p_4343", "content": "Hydroxyindoleacetic Acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8275, 19554, 13722, 2687, 3, 3]}]}
{"query": {"id": "q_4344", "content": "aggressive behavior [SEP]  users with low central 5-HT may be especially prone to exhibit aggressive behavior.", "tokenized_content": [2, 8704, 3379, 3, 6603, 1956, 2330, 4101, 25, 17, 5334, 2278, 1998, 4369, 10424, 1942, 5987, 8704, 3379, 18, 3]}, "items": [{"id": "p_4344", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4345", "content": "paclitaxel [SEP] Intracavitary chemotherapy (paclitaxel/carboplatin liquid crystalline cubic phases) for recurrent glio", "tokenized_content": [2, 12404, 3, 4245, 9188, 3857, 6907, 5318, 12, 12404, 19, 20072, 5875, 14631, 18816, 7643, 13, 1958, 7457, 6534, 1037, 3]}, "items": [{"id": "p_4345", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_4346", "content": "carboplatin [SEP] Intracavitary chemotherapy (paclitaxel/carboplatin liquid crystalline cubic phases) for recurrent glioblastoma -- ", "tokenized_content": [2, 20072, 3, 4245, 9188, 3857, 6907, 5318, 12, 12404, 19, 20072, 5875, 14631, 18816, 7643, 13, 1958, 7457, 14224, 17, 17, 3]}, "items": [{"id": "p_4346", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_4347", "content": "glioblastoma [SEP] axel/carboplatin liquid crystalline cubic phases) for recurrent glioblastoma -- clinical observations.", "tokenized_content": [2, 14224, 3, 3565, 1938, 19, 20072, 5875, 14631, 18816, 7643, 13, 1958, 7457, 14224, 17, 17, 2535, 5184, 18, 3]}, "items": [{"id": "p_4347", "content": "Glioblastoma [SEP] A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necr", "score": 1, "type": null, "tokenized_content": [2, 14224, 3, 43, 6558, 2386, 1927, 29941, 15055, 4378, 2007, 6483, 10728, 2421, 1927, 2094, 16, 4254, 10222, 2126, 16, 2703, 20730, 6990, 2170, 16, 1930, 3296, 1005, 3]}]}
{"query": {"id": "q_4348", "content": "brain tumors [SEP] Human malignant brain tumors have a poor prognosis in spite of surgery and radiation therapy", "tokenized_content": [2, 3068, 3861, 3, 2616, 6558, 3068, 3861, 2162, 43, 3930, 6573, 1922, 14168, 1927, 3782, 1930, 5442, 3181, 3]}, "items": [{"id": "p_4348", "content": "Brain Neoplasms [SEP] Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypot", "score": 1, "type": null, "tokenized_content": [2, 3068, 15347, 3, 15347, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 16, 2710, 1920, 6329, 21098, 16, 5342, 13086, 16, 12201, 3]}]}
{"query": {"id": "q_4349", "content": "glioblastoma [SEP]  applied to the walls of a surgical resection cavity. For human glioblastoma recurrences, the feasibility, safety, and short-term effects of", "tokenized_content": [2, 14224, 3, 3730, 1942, 1920, 12430, 1927, 43, 4548, 6953, 8568, 18, 1958, 2616, 14224, 19130, 16, 1920, 10067, 16, 5407, 16, 1930, 3662, 17, 2576, 2564, 1927, 3]}, "items": [{"id": "p_4349", "content": "Glioblastoma [SEP] A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necr", "score": 1, "type": null, "tokenized_content": [2, 14224, 3, 43, 6558, 2386, 1927, 29941, 15055, 4378, 2007, 6483, 10728, 2421, 1927, 2094, 16, 4254, 10222, 2126, 16, 2703, 20730, 6990, 2170, 16, 1930, 3296, 1005, 3]}]}
{"query": {"id": "q_4350", "content": "paclitaxel [SEP] d short-term effects of a surgical intracavitary application of paclitaxel and carboplatin encapsulated by liquid crystalline cubic phases", "tokenized_content": [2, 12404, 3, 46, 3662, 17, 2576, 2564, 1927, 43, 4548, 4245, 9188, 3857, 6907, 4722, 1927, 12404, 1930, 20072, 15358, 2007, 5875, 14631, 18816, 7643, 3]}, "items": [{"id": "p_4350", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_4351", "content": "carboplatin [SEP] fects of a surgical intracavitary application of paclitaxel and carboplatin encapsulated by liquid crystalline cubic phases are examined in", "tokenized_content": [2, 20072, 3, 16688, 1973, 1927, 43, 4548, 4245, 9188, 3857, 6907, 4722, 1927, 12404, 1930, 20072, 15358, 2007, 5875, 14631, 18816, 7643, 2032, 3572, 1922, 3]}, "items": [{"id": "p_4351", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_4352", "content": "brain edema [SEP] more than 15 mg paclitaxel and suffered from moderate to severe brain edema, while the remaining patients received only a total of 15 mg pa", "tokenized_content": [2, 3068, 10144, 3, 2253, 2254, 2461, 2786, 12404, 1930, 13949, 2037, 5086, 1942, 4010, 3068, 10144, 16, 2679, 1920, 5719, 2132, 4004, 2444, 43, 2698, 1927, 2461, 2786, 3838, 3]}, "items": [{"id": "p_4352", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_4353", "content": "Methylphenidate [SEP] Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.", "tokenized_content": [2, 4963, 17616, 21550, 3, 4963, 17616, 21550, 17, 2719, 25555, 17, 21543, 3601, 1922, 1925, 7354, 2323, 18, 3]}, "items": [{"id": "p_4353", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_4354", "content": "obsessive-compulsive symptoms [SEP] Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.", "tokenized_content": [2, 25555, 17, 21543, 3601, 3, 4963, 17616, 21550, 17, 2719, 25555, 17, 21543, 3601, 1922, 1925, 7354, 2323, 18, 3]}, "items": [{"id": "p_4354", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_4355", "content": "treatment-resistant depression [SEP] An 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. S", "tokenized_content": [2, 2311, 17, 4910, 4621, 3, 1925, 6175, 17, 2476, 17, 4156, 2323, 1956, 2311, 17, 4910, 4621, 1930, 3120, 9116, 11, 61, 2573, 1982, 8074, 1990, 4963, 17616, 21550, 18, 3]}, "items": [{"id": "p_4355", "content": "Depressive Disorder, Treatment-Resistant [SEP] Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 16, 2311, 17, 4910, 3, 4574, 1942, 4409, 1942, 2288, 2014, 2253, 3848, 1927, 14183, 13767, 2014, 4574, 1942, 4409, 1942, 3006, 2014, 2253, 3848, 1927, 2413, 3]}]}
{"query": {"id": "q_4356", "content": "Alzheimer's disease [SEP] n 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsiv", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 56, 6175, 17, 2476, 17, 4156, 2323, 1956, 2311, 17, 4910, 4621, 1930, 3120, 9116, 11, 61, 2573, 1982, 8074, 1990, 4963, 17616, 21550, 18, 3]}, "items": [{"id": "p_4356", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_4357", "content": "methylphenidate [SEP] sistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminishe", "tokenized_content": [2, 4963, 17616, 21550, 3, 19149, 3285, 1031, 4621, 1930, 3120, 9116, 11, 61, 2573, 1982, 8074, 1990, 4963, 17616, 21550, 18, 2228, 25555, 17, 21543, 3379, 4847, 6436, 2308, 16072, 3]}, "items": [{"id": "p_4357", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_4358", "content": "obsessive-compulsive behavior [SEP] Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminished over several weeks when methylphenidate w", "tokenized_content": [2, 25555, 17, 21543, 3379, 3, 9116, 11, 61, 2573, 1982, 8074, 1990, 4963, 17616, 21550, 18, 2228, 25555, 17, 21543, 3379, 4847, 6436, 2308, 9597, 2338, 2980, 3625, 2469, 4963, 3]}, "items": [{"id": "p_4358", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_4359", "content": "fluvoxamine [SEP] inished over several weeks when methylphenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sis", "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 1922, 5270, 2338, 2980, 3625, 2469, 4963, 17616, 21550, 1982, 8403, 2007, 2848, 15525, 11414, 25157, 18, 1920, 2774, 2430, 2239, 3432, 7652, 4403, 16, 3]}, "items": [{"id": "p_4359", "content": "Fluvoxamine [SEP] A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 43, 5328, 11153, 22957, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 1930, 43, 5386, 1927, 5592, 4414, 18, 3]}]}
{"query": {"id": "q_4360", "content": "psychiatric [SEP] phenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder", "tokenized_content": [2, 7652, 3, 3037, 21550, 1982, 8403, 2007, 2848, 15525, 11414, 25157, 18, 1920, 2774, 2430, 2239, 3432, 7652, 4403, 16, 2308, 2234, 2430, 43, 14611, 1956, 25555, 17, 21543, 4770, 3]}, "items": [{"id": "p_4360", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4361", "content": "obsessive-compulsive disorder [SEP] ient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder. It appears that methylphenidate precipitated the patient's pat", "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 10116, 4905, 2430, 2239, 3432, 7652, 4403, 16, 2308, 2234, 2430, 43, 14611, 1956, 25555, 17, 21543, 4770, 18, 2176, 5107, 1988, 4963, 17616, 21550, 3]}, "items": [{"id": "p_4361", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_4362", "content": "Cardiac arrest [SEP] Cardiac arrest after intravenous metoclopramide - a case of five repeated inje", "tokenized_content": [2, 4435, 8048, 3, 4435, 8048, 2256, 7307, 2130, 5406, 27148, 2261, 17, 43, 3087, 1927, 3628, 5116, 2831, 1021, 3]}, "items": [{"id": "p_4362", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4363", "content": "metoclopramide [SEP] Cardiac arrest after intravenous metoclopramide - a case of five repeated injections of metoclopramide causing ", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 4435, 8048, 2256, 7307, 2130, 5406, 27148, 2261, 17, 43, 3087, 1927, 3628, 5116, 8775, 1927, 2130, 5406, 27148, 2261, 7538, 3]}, "items": [{"id": "p_4363", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_4364", "content": "cardiac arrest [SEP]  repeated injections of metoclopramide causing five episodes of cardiac arrest.", "tokenized_content": [2, 4435, 8048, 3, 5116, 8775, 1927, 2130, 5406, 27148, 2261, 7538, 3628, 9232, 1927, 4435, 8048, 18, 3]}, "items": [{"id": "p_4364", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4365", "content": "metoclopramide [SEP] We describe a patient where intravenous injection of metoclopramide was immediately followed by asystole repeatedly. The patient re", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 2038, 5993, 43, 2774, 2597, 7307, 4107, 1927, 2130, 5406, 27148, 2261, 1982, 6183, 3489, 2007, 1966, 2298, 2456, 14959, 18, 1920, 2774, 1964, 3]}, "items": [{"id": "p_4365", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_4366", "content": "asystole [SEP] avenous injection of metoclopramide was immediately followed by asystole repeatedly. The patient received metoclopramide 10 mg i.v. five", "tokenized_content": [2, 1966, 2298, 2456, 3, 16959, 2080, 4107, 1927, 2130, 5406, 27148, 2261, 1982, 6183, 3489, 2007, 1966, 2298, 2456, 14959, 18, 1920, 2774, 4004, 2130, 5406, 27148, 2261, 2119, 2786, 3]}, "items": [{"id": "p_4366", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4367", "content": "atropine [SEP] ccasions, on one occasion it lasted 2 min. The patient received atropine 0.5-1 mg and chest compressions, before sinus rhythm again took", "tokenized_content": [2, 24031, 3, 13980, 12924, 2101, 16, 1990, 2340, 10629, 2176, 16276, 22, 2360, 18, 1920, 2774, 4004, 24031, 20, 18, 25, 17, 21, 2786, 1930, 8475, 10399, 1036, 16, 3119, 3]}, "items": [{"id": "p_4367", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_4368", "content": "cardiac arrest [SEP]  sinus rhythm again took over. We interpret this as episodes of cardiac arrest caused by metoclopramide. The rapid injection via the central v", "tokenized_content": [2, 4435, 8048, 3, 9414, 11529, 3116, 8659, 2338, 18, 2038, 10307, 2052, 1966, 9232, 1927, 4435, 8048, 4189, 2007, 2130, 5406, 27148, 2261, 18, 1920, 4052, 4107, 3454, 1920, 4101, 3]}, "items": [{"id": "p_4368", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4369", "content": "dopamine [SEP] on via the central venous route and the concomitant tapering of dopamine infusion might have contributed in precipitating the adverse dr", "tokenized_content": [2, 7964, 3, 1990, 3454, 1920, 4101, 8562, 9629, 1930, 1920, 8537, 22340, 1941, 1927, 7964, 7386, 3284, 2162, 6505, 1922, 9637, 2287, 1920, 5246, 2324, 3]}, "items": [{"id": "p_4369", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4370", "content": "hemolytic anemia [SEP] Severe immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and ", "tokenized_content": [2, 21515, 10679, 3, 4010, 3743, 21515, 10679, 2458, 1956, 14847, 2485, 1927, 13724, 7229, 3285, 1922, 18902, 1930, 3]}, "items": [{"id": "p_4370", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4371", "content": "cefotetan [SEP] ere immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and gynecologic procedures.", "tokenized_content": [2, 13724, 7229, 3285, 3, 22561, 3743, 21515, 10679, 2458, 1956, 14847, 2485, 1927, 13724, 7229, 3285, 1922, 18902, 1930, 26557, 4869, 18, 3]}, "items": [{"id": "p_4371", "content": "Cefotetan [SEP] A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a b", "score": 1, "type": null, "tokenized_content": [2, 13724, 7229, 3285, 3, 43, 8762, 18801, 4905, 4116, 2002, 17008, 8527, 4636, 7267, 1988, 1977, 5254, 15132, 2014, 16774, 1954, 18, 1920, 2838, 1977, 3626, 4910, 1942, 43, 44, 3]}]}
{"query": {"id": "q_4372", "content": "cephalosporins [SEP] Second- and third-generation cephalosporins, especially cefotetan, are increasingly associated with severe,", "tokenized_content": [2, 25091, 2925, 3, 2812, 17, 1930, 4563, 17, 4841, 25091, 2925, 16, 4369, 13724, 7229, 3285, 16, 2032, 8827, 2458, 1956, 4010, 16, 3]}, "items": [{"id": "p_4372", "content": "Cephalosporins [SEP] A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moie", "score": 1, "type": null, "tokenized_content": [2, 25091, 2925, 3, 43, 2210, 1927, 4949, 17, 5648, 7560, 2561, 3937, 2037, 1920, 16825, 16461, 10428, 1987, 15414, 18, 2611, 5531, 1920, 4666, 17, 15294, 15295, 1021, 3]}]}
{"query": {"id": "q_4373", "content": "cefotetan [SEP] Second- and third-generation cephalosporins, especially cefotetan, are increasingly associated with severe, sometimes fatal immun", "tokenized_content": [2, 13724, 7229, 3285, 3, 2812, 17, 1930, 4563, 17, 4841, 25091, 2925, 16, 4369, 13724, 7229, 3285, 16, 2032, 8827, 2458, 1956, 4010, 16, 8929, 11990, 2519, 3]}, "items": [{"id": "p_4373", "content": "Cefotetan [SEP] A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a b", "score": 1, "type": null, "tokenized_content": [2, 13724, 7229, 3285, 3, 43, 8762, 18801, 4905, 4116, 2002, 17008, 8527, 4636, 7267, 1988, 1977, 5254, 15132, 2014, 16774, 1954, 18, 1920, 2838, 1977, 3626, 4910, 1942, 43, 44, 3]}]}
{"query": {"id": "q_4374", "content": "hemolytic anemia [SEP] are increasingly associated with severe, sometimes fatal immune hemolytic anemia. We noticed that 10 of our 35 cases of cefotetan-induced hemoly", "tokenized_content": [2, 21515, 10679, 3, 2032, 8827, 2458, 1956, 4010, 16, 8929, 11990, 3743, 21515, 10679, 18, 2038, 14114, 1988, 2119, 1927, 2342, 3259, 2919, 1927, 13724, 7229, 3285, 17, 2719, 3243, 3]}, "items": [{"id": "p_4374", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4375", "content": "hemolytic anemias [SEP] anemia. We noticed that 10 of our 35 cases of cefotetan-induced hemolytic anemias were in patients who had received cefotetan prophylactically fo", "tokenized_content": [2, 21515, 10679, 1036, 3, 10679, 18, 2038, 14114, 1988, 2119, 1927, 2342, 3259, 2919, 1927, 13724, 7229, 3285, 17, 2719, 21515, 10679, 1036, 1985, 1922, 2132, 2746, 2430, 4004, 13724, 3]}, "items": [{"id": "p_4375", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4376", "content": "Cauda equina syndrome [SEP] Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a revie", "tokenized_content": [2, 10268, 1019, 3009, 4058, 4741, 3, 10268, 1019, 3009, 4058, 4741, 2256, 6071, 17107, 1956, 4194, 8751, 1935, 25, 9, 12975, 17678, 30, 43, 5197, 2621, 3]}, "items": [{"id": "p_4376", "content": "Polyradiculopathy [SEP] Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.\n", "score": 1, "type": null, "tokenized_content": [2, 4286, 26208, 16058, 6522, 3, 2573, 2014, 4047, 5884, 3137, 6071, 5507, 9398, 18, 4286, 26208, 16058, 3678, 11238, 1942, 4531, 1927, 3137, 6071, 5507, 9398, 18, 3]}]}
{"query": {"id": "q_4377", "content": "lignocaine [SEP] uda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the", "tokenized_content": [2, 12975, 17678, 3, 19803, 1019, 3009, 4058, 4741, 2256, 6071, 17107, 1956, 4194, 8751, 1935, 25, 9, 12975, 17678, 30, 43, 3043, 1927, 3798, 2919, 1927, 10268, 1019, 3009, 4058, 3]}, "items": [{"id": "p_4377", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_4378", "content": "cauda equina syndrome [SEP] sthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997.", "tokenized_content": [2, 10268, 1019, 3009, 4058, 4741, 3, 1955, 4483, 2126, 1956, 4194, 8751, 1935, 25, 9, 12975, 17678, 30, 43, 3043, 1927, 3798, 2919, 1927, 10268, 1019, 3009, 4058, 4741, 2568, 3]}, "items": [{"id": "p_4378", "content": "Polyradiculopathy [SEP] Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.\n", "score": 1, "type": null, "tokenized_content": [2, 4286, 26208, 16058, 6522, 3, 2573, 2014, 4047, 5884, 3137, 6071, 5507, 9398, 18, 4286, 26208, 16058, 3678, 11238, 1942, 4531, 1927, 3137, 6071, 5507, 9398, 18, 3]}]}
{"query": {"id": "q_4379", "content": "cauda equina syndrome [SEP] Six cases of cauda equina syndrome with varying severity were reported to the Swedish Pharmaceutic", "tokenized_content": [2, 10268, 1019, 3009, 4058, 4741, 3, 3798, 2919, 1927, 10268, 1019, 3009, 4058, 4741, 1956, 7155, 5155, 1985, 2568, 1942, 1920, 15110, 9127, 2002, 3]}, "items": [{"id": "p_4379", "content": "Polyradiculopathy [SEP] Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.\n", "score": 1, "type": null, "tokenized_content": [2, 4286, 26208, 16058, 6522, 3, 2573, 2014, 4047, 5884, 3137, 6071, 5507, 9398, 18, 4286, 26208, 16058, 3678, 11238, 1942, 4531, 1927, 3137, 6071, 5507, 9398, 18, 3]}]}
{"query": {"id": "q_4380", "content": "lignocaine [SEP] All were associated with spinal anaesthesia using hyperbaric 5% lignocaine. Five cases had single-shot spinal anaesthesia and one had a re", "tokenized_content": [2, 12975, 17678, 3, 2136, 1985, 2458, 1956, 6071, 17107, 2193, 4194, 8751, 1935, 25, 9, 12975, 17678, 18, 3628, 2919, 2430, 2957, 17, 16923, 6071, 17107, 1930, 2340, 2430, 43, 3]}, "items": [{"id": "p_4380", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_4381", "content": "neurotoxicity [SEP] to 120 mg. Three of the cases were most likely caused by direct neurotoxicity of hyperbaric 5% lignocaine. In the other 3 cases, direct neuro", "tokenized_content": [2, 18034, 3, 1942, 6103, 2786, 18, 2559, 1927, 1920, 2919, 1985, 2501, 3205, 4189, 2007, 3083, 18034, 1927, 4194, 8751, 1935, 25, 9, 12975, 17678, 18, 1922, 1920, 2303, 23, 3]}, "items": [{"id": "p_4381", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4382", "content": "neurological deficits [SEP]  exclude a compressive aetiology. All cases sustained permanent neurological deficits. We recommend that hyperbaric lignocaine should be administered", "tokenized_content": [2, 7605, 7961, 3, 10443, 43, 18978, 22717, 18, 2136, 2919, 7637, 11047, 7605, 7961, 18, 2038, 5732, 1988, 4194, 8751, 1935, 12975, 17678, 3066, 1998, 5254, 3]}, "items": [{"id": "p_4382", "content": "Neurologic Manifestations [SEP] Clinical signs and symptoms caused by nervous system injury or dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14314, 10952, 3, 2535, 6879, 1930, 3601, 4189, 2007, 7580, 2433, 4047, 2014, 5273, 18, 3]}]}
{"query": {"id": "q_4383", "content": "parkinsonian [SEP] Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia.", "tokenized_content": [2, 10124, 3122, 3, 5586, 4842, 2338, 6042, 1922, 10124, 3122, 2132, 1956, 54, 17, 19428, 17, 2719, 3833, 17, 3253, 3890, 26682, 18, 3]}, "items": [{"id": "p_4383", "content": "Parkinsonian Disorders [SEP] A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural i", "score": 1, "type": null, "tokenized_content": [2, 10124, 3122, 4414, 3, 43, 2210, 1927, 4414, 2154, 5961, 5761, 4842, 2285, 4378, 2007, 20152, 26682, 16, 3760, 20471, 31, 18388, 31, 1930, 17198, 51, 3]}]}
{"query": {"id": "q_4384", "content": "L-dopa [SEP] Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia.", "tokenized_content": [2, 54, 17, 19428, 3, 5586, 4842, 2338, 6042, 1922, 10124, 3122, 2132, 1956, 54, 17, 19428, 17, 2719, 3833, 17, 3253, 3890, 26682, 18, 3]}, "items": [{"id": "p_4384", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4385", "content": "dyskinesia [SEP] tivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia.", "tokenized_content": [2, 3890, 26682, 3, 8685, 9664, 1922, 10124, 3122, 2132, 1956, 54, 17, 19428, 17, 2719, 3833, 17, 3253, 3890, 26682, 18, 3]}, "items": [{"id": "p_4385", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4386", "content": "parkinsonian [SEP]  in the supplementary and primary motor cortex of two groups of parkinsonian patients on L-dopa medication, the first one without L-dopa ind", "tokenized_content": [2, 10124, 3122, 3, 1922, 1920, 3768, 1930, 3065, 4842, 4997, 1927, 2288, 2671, 1927, 10124, 3122, 2132, 1990, 54, 17, 19428, 6093, 16, 1920, 2561, 2340, 2979, 54, 17, 19428, 3]}, "items": [{"id": "p_4386", "content": "Parkinsonian Disorders [SEP] A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural i", "score": 1, "type": null, "tokenized_content": [2, 10124, 3122, 4414, 3, 43, 2210, 1927, 4414, 2154, 5961, 5761, 4842, 2285, 4378, 2007, 20152, 26682, 16, 3760, 20471, 31, 18388, 31, 1930, 17198, 51, 3]}]}
{"query": {"id": "q_4387", "content": "L-dopa [SEP]  primary motor cortex of two groups of parkinsonian patients on L-dopa medication, the first one without L-dopa induced dyskinesia (n ", "tokenized_content": [2, 54, 17, 19428, 3, 3065, 4842, 4997, 1927, 2288, 2671, 1927, 10124, 3122, 2132, 1990, 54, 17, 19428, 6093, 16, 1920, 2561, 2340, 2979, 54, 17, 19428, 2719, 3890, 26682, 3]}, "items": [{"id": "p_4387", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4388", "content": "dyskinesia [SEP] ents on L-dopa medication, the first one without L-dopa induced dyskinesia (n = 23) and the other with moderate peak-dose dyskinesia (n = ", "tokenized_content": [2, 3890, 26682, 3, 8496, 1036, 1990, 54, 17, 19428, 6093, 16, 1920, 2561, 2340, 2979, 54, 17, 19428, 2719, 3890, 26682, 12, 56, 33, 3020, 13, 1930, 1920, 2303, 1956, 3]}, "items": [{"id": "p_4388", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4389", "content": "dyskinetic [SEP] raphy with i.v. 133Xe was used to measure the rCBF changes. The dyskinetic parkinsonian patients exhibited a pattern of response which was", "tokenized_content": [2, 3890, 24590, 2002, 3, 23590, 1012, 1956, 51, 18, 64, 18, 12147, 1039, 1021, 1982, 2251, 1942, 2931, 1920, 7399, 19781, 2840, 18, 1920, 3890, 24590, 2002, 10124, 3122, 2132, 3]}, "items": [{"id": "p_4389", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4390", "content": "hyperkinetic [SEP] areas. These results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dy", "tokenized_content": [2, 4194, 24590, 2002, 3, 3957, 18, 2144, 2274, 2032, 11290, 1956, 1920, 4676, 1988, 1925, 4194, 24590, 2002, 4552, 28493, 5829, 16, 3189, 54, 17, 19428, 17, 2719, 3833, 3253, 3]}, "items": [{"id": "p_4390", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_4391", "content": "abnormal involuntary movement [SEP] results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dyskinesia, is due to a disinhib", "tokenized_content": [2, 4552, 28493, 5829, 3, 2274, 2032, 11290, 1956, 1920, 4676, 1988, 1925, 4194, 24590, 2002, 4552, 28493, 5829, 16, 3189, 54, 17, 19428, 17, 2719, 3833, 3253, 3890, 26682, 16, 3]}, "items": [{"id": "p_4391", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4392", "content": "Dexamethasone [SEP] Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes.", "tokenized_content": [2, 12681, 3, 12681, 17, 2719, 10046, 5579, 1922, 8368, 17, 4789, 2616, 7127, 18, 3]}, "items": [{"id": "p_4392", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4393", "content": "ocular hypertension [SEP] Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes.", "tokenized_content": [2, 10046, 5579, 3, 12681, 17, 2719, 10046, 5579, 1922, 8368, 17, 4789, 2616, 7127, 18, 3]}, "items": [{"id": "p_4393", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_4394", "content": "ocular hypertension [SEP] E: Glucocorticoid administration can lead to the development of ocular hypertension and corticosteroid glaucoma in a subset of the population throu", "tokenized_content": [2, 10046, 5579, 3, 47, 30, 14469, 4183, 2112, 2949, 1942, 1920, 2740, 1927, 10046, 5579, 1930, 17980, 12106, 1922, 43, 6728, 1927, 1920, 2973, 21980, 1032, 3]}, "items": [{"id": "p_4394", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_4395", "content": "corticosteroid glaucoma [SEP] stration can lead to the development of ocular hypertension and corticosteroid glaucoma in a subset of the population through a decrease in the aqueous", "tokenized_content": [2, 17980, 12106, 3, 9402, 1929, 2112, 2949, 1942, 1920, 2740, 1927, 10046, 5579, 1930, 17980, 12106, 1922, 43, 6728, 1927, 1920, 2973, 2596, 43, 3714, 1922, 1920, 8052, 3]}, "items": [{"id": "p_4395", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_4396", "content": "dexamethasone [SEP] eyes were perfused in serum-free media with or without 10(-7) M dexamethasone for 12 days. Intraocular pressure was monitored daily. After in", "tokenized_content": [2, 12681, 3, 7127, 1985, 13699, 1922, 3256, 17, 3294, 4996, 1956, 2014, 2979, 2119, 12, 17, 27, 13, 55, 12681, 1958, 2369, 3000, 18, 17258, 3772, 1982, 7027, 4692, 18, 3]}, "items": [{"id": "p_4396", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4397", "content": "hypertensive eyes [SEP]  morphologically normal. In contrast, the dexamethasone-treated hypertensive eyes had thickened trabecular beams, decreased intertrabecular space", "tokenized_content": [2, 11706, 7127, 3, 17312, 2791, 18, 1922, 3320, 16, 1920, 12681, 17, 2868, 11706, 7127, 2430, 25981, 15855, 19419, 16, 3261, 27332, 5524, 12409, 2168, 5230, 3]}, "items": [{"id": "p_4397", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_4398", "content": "Dexamethasone [SEP] methasone-induced morphologic changes were evident. CONCLUSION: Dexamethasone treatment of isolated, perfusion-cultured human eyes led to the", "tokenized_content": [2, 12681, 3, 2295, 11718, 17, 2719, 19599, 2840, 1985, 7501, 18, 4180, 30, 12681, 2311, 1927, 3937, 16, 8368, 17, 4789, 2616, 7127, 4866, 1942, 1920, 3]}, "items": [{"id": "p_4398", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4399", "content": "Steroid [SEP] tension in approximately 30% of the dexamethasone-treated eyes. Steroid treatment resulted in morphologic changes in the trabecular mes", "tokenized_content": [2, 9507, 3, 10146, 1922, 3993, 2627, 9, 1927, 1920, 12681, 17, 2868, 7127, 18, 9507, 2311, 4306, 1922, 19599, 2840, 1922, 1920, 15855, 4438, 3]}, "items": [{"id": "p_4399", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4400", "content": "open angle glaucoma [SEP] hwork similar to those reported for corticosteroid glaucoma and open angle glaucoma. This system may provide an acute model in which to study the p", "tokenized_content": [2, 4437, 6524, 12106, 3, 18515, 2449, 2551, 1942, 2690, 2568, 1958, 17980, 12106, 1930, 4437, 6524, 12106, 18, 2052, 2433, 2278, 3394, 1925, 3939, 2322, 1922, 2154, 1942, 2161, 1920, 3]}, "items": [{"id": "p_4400", "content": "Glaucoma, Open-Angle [SEP] Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iri", "score": 1, "type": null, "tokenized_content": [2, 12106, 16, 4437, 17, 6524, 3, 12106, 1922, 2154, 1920, 6524, 1927, 1920, 5477, 7329, 1977, 4437, 1930, 1920, 15855, 10238, 3396, 3731, 2084, 3350, 1931, 2155, 1990, 1920, 5170, 1927, 1920, 24768, 3]}]}
{"query": {"id": "q_4401", "content": "steroid glaucoma [SEP] n can lead to the development of ocular hypertension and corticosteroid glaucoma in a subset of the population through a decrease in the aqueous", "tokenized_content": [2, 9507, 12106, 3, 56, 2112, 2949, 1942, 1920, 2740, 1927, 10046, 5579, 1930, 17980, 12106, 1922, 43, 6728, 1927, 1920, 2973, 2596, 43, 3714, 1922, 1920, 8052, 3]}, "items": [{"id": "p_4401", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_4402", "content": "primary open angle glaucoma [SEP] tudy the pathogenic mechanisms involved in steroid glaucoma and primary open angle glaucoma.", "tokenized_content": [2, 3065, 4437, 6524, 12106, 3, 9037, 14458, 1920, 8070, 3531, 3286, 1922, 9507, 12106, 1930, 3065, 4437, 6524, 12106, 18, 3]}, "items": [{"id": "p_4402", "content": "Glaucoma, Open-Angle [SEP] Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iri", "score": 1, "type": null, "tokenized_content": [2, 12106, 16, 4437, 17, 6524, 3, 12106, 1922, 2154, 1920, 6524, 1927, 1920, 5477, 7329, 1977, 4437, 1930, 1920, 15855, 10238, 3396, 3731, 2084, 3350, 1931, 2155, 1990, 1920, 5170, 1927, 1920, 24768, 3]}]}
{"query": {"id": "q_4403", "content": "Cognitive deterioration [SEP] Cognitive deterioration from long-term abuse of dextromethorphan: a case report.", "tokenized_content": [2, 4328, 13318, 3, 4328, 13318, 2037, 2815, 17, 2576, 7764, 1927, 20256, 4191, 1963, 4255, 1928, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4403", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_4404", "content": "dextromethorphan [SEP] Cognitive deterioration from long-term abuse of dextromethorphan: a case report.", "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 4328, 13318, 2037, 2815, 17, 2576, 7764, 1927, 20256, 4191, 1963, 4255, 1928, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4404", "content": "Dextromethorphan [SEP] Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough cen", "score": 1, "type": null, "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 4963, 5729, 1927, 20256, 8478, 18547, 1988, 3661, 2149, 5173, 2743, 1942, 2980, 3451, 1927, 1920, 3068, 16, 2710, 1920, 19482, 13588, 14585, 3]}]}
{"query": {"id": "q_4405", "content": "Dextromethorphan [SEP] Dextromethorphan (DM), the dextrorotatory isomer of 3-hydroxy-N-methylmorphinan,", "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 20256, 4191, 1963, 4255, 1928, 12, 3931, 13, 16, 1920, 20256, 8478, 7336, 27708, 15348, 1927, 23, 17, 8275, 17, 56, 17, 4963, 12492, 3]}, "items": [{"id": "p_4405", "content": "Dextromethorphan [SEP] Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough cen", "score": 1, "type": null, "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 4963, 5729, 1927, 20256, 8478, 18547, 1988, 3661, 2149, 5173, 2743, 1942, 2980, 3451, 1927, 1920, 3068, 16, 2710, 1920, 19482, 13588, 14585, 3]}]}
{"query": {"id": "q_4406", "content": "DM [SEP] Dextromethorphan (DM), the dextrorotatory isomer of 3-hydroxy-N-methylmorphinan, is ", "tokenized_content": [2, 3931, 3, 20256, 4191, 1963, 4255, 1928, 12, 3931, 13, 16, 1920, 20256, 8478, 7336, 27708, 15348, 1927, 23, 17, 8275, 17, 56, 17, 4963, 12492, 11119, 7969, 24254, 16, 3]}, "items": [{"id": "p_4406", "content": "Dextromethorphan [SEP] Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough cen", "score": 1, "type": null, "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 4963, 5729, 1927, 20256, 8478, 18547, 1988, 3661, 2149, 5173, 2743, 1942, 2980, 3451, 1927, 1920, 3068, 16, 2710, 1920, 19482, 13588, 14585, 3]}]}
{"query": {"id": "q_4407", "content": "3-hydroxy-N-methylmorphinan [SEP] Dextromethorphan (DM), the dextrorotatory isomer of 3-hydroxy-N-methylmorphinan, is the main ingredient in a number of widely available, over-t", "tokenized_content": [2, 23, 17, 8275, 17, 56, 17, 4963, 12492, 11119, 7969, 24254, 3, 20256, 4191, 1963, 4255, 1928, 12, 3931, 13, 16, 1920, 20256, 8478, 7336, 27708, 15348, 1927, 23, 17, 3]}, "items": [{"id": "p_4407", "content": "Levorphanol [SEP] A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 11119, 15409, 1945, 3, 43, 22872, 3153, 14501, 1988, 2278, 1998, 7954, 17, 7402, 18, 2176, 1977, 6737, 1966, 3655, 12950, 1966, 2007, 4107, 18, 3]}]}
{"query": {"id": "q_4408", "content": "nausea [SEP] s known to cause a variety of acute toxic effects, ranging from nausea, restlessness, insomnia, ataxia, slurred speech and nystagmus t", "tokenized_content": [2, 13759, 3, 61, 3171, 1942, 3936, 43, 5386, 1927, 3939, 6161, 2564, 16, 6485, 2037, 13759, 16, 6172, 26481, 16, 16882, 16, 17698, 16, 2788, 19294, 8560, 1930, 26133, 11431, 3]}, "items": [{"id": "p_4408", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4409", "content": "restlessness [SEP] to cause a variety of acute toxic effects, ranging from nausea, restlessness, insomnia, ataxia, slurred speech and nystagmus to mood changes", "tokenized_content": [2, 6172, 26481, 3, 1942, 3936, 43, 5386, 1927, 3939, 6161, 2564, 16, 6485, 2037, 13759, 16, 6172, 26481, 16, 16882, 16, 17698, 16, 2788, 19294, 8560, 1930, 26133, 11431, 1957, 3]}, "items": [{"id": "p_4409", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_4410", "content": "insomnia [SEP] iety of acute toxic effects, ranging from nausea, restlessness, insomnia, ataxia, slurred speech and nystagmus to mood changes, perceptu", "tokenized_content": [2, 16882, 3, 10116, 3145, 1927, 3939, 6161, 2564, 16, 6485, 2037, 13759, 16, 6172, 26481, 16, 16882, 16, 17698, 16, 2788, 19294, 8560, 1930, 26133, 11431, 1957, 1942, 9494, 2840, 3]}, "items": [{"id": "p_4410", "content": "Sleep Initiation and Maintenance Disorders [SEP] Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in a", "score": 1, "type": null, "tokenized_content": [2, 5006, 6035, 1930, 6291, 4414, 3, 4414, 4378, 2007, 6159, 1927, 1920, 3682, 1942, 11051, 2014, 6698, 5006, 18, 2052, 2278, 4704, 1966, 43, 3065, 4770, 2014, 1922, 43, 3]}]}
{"query": {"id": "q_4411", "content": "ataxia [SEP] ute toxic effects, ranging from nausea, restlessness, insomnia, ataxia, slurred speech and nystagmus to mood changes, perceptual alter", "tokenized_content": [2, 17698, 3, 11112, 1021, 6161, 2564, 16, 6485, 2037, 13759, 16, 6172, 26481, 16, 16882, 16, 17698, 16, 2788, 19294, 8560, 1930, 26133, 11431, 1957, 1942, 9494, 2840, 16, 12365, 3]}, "items": [{"id": "p_4411", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_4412", "content": "nystagmus [SEP] from nausea, restlessness, insomnia, ataxia, slurred speech and nystagmus to mood changes, perceptual alterations, inattention, disorient", "tokenized_content": [2, 26133, 11431, 1957, 3, 2037, 13759, 16, 6172, 26481, 16, 16882, 16, 17698, 16, 2788, 19294, 8560, 1930, 26133, 11431, 1957, 1942, 9494, 2840, 16, 12365, 5996, 16, 27351, 2546, 3]}, "items": [{"id": "p_4412", "content": "Nystagmus, Myoclonic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26133, 11431, 1957, 16, 15924, 2223, 3490, 3, 3]}]}
{"query": {"id": "q_4413", "content": "aggressive behavior [SEP] hanges, perceptual alterations, inattention, disorientation and aggressive behavior (Rammer et al 1988; Katona and Watson 1986; Isbell and Fraser 1", "tokenized_content": [2, 8704, 3379, 3, 29666, 1918, 16, 12365, 5996, 16, 27351, 2546, 16, 2054, 29292, 1930, 8704, 3379, 12, 8221, 9213, 2140, 1969, 10337, 31, 14164, 12502, 1930, 22151, 11367, 31, 3]}, "items": [{"id": "p_4413", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4414", "content": "cognitive deterioration [SEP] g the effects of chronic abuse. This report describes a case of cognitive deterioration resulting from prolonged use of DM.", "tokenized_content": [2, 4328, 13318, 3, 49, 1920, 2564, 1927, 3724, 7764, 18, 2052, 3809, 9845, 43, 3087, 1927, 4328, 13318, 3864, 2037, 7171, 2485, 1927, 3931, 18, 3]}, "items": [{"id": "p_4414", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_4415", "content": "lithium [SEP] Long-term lithium treatment and the kidney. Interim report on fifty patients.", "tokenized_content": [2, 14330, 3, 2815, 17, 2576, 14330, 2311, 1930, 1920, 5245, 18, 23631, 3809, 1990, 12357, 2132, 18, 3]}, "items": [{"id": "p_4415", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_4416", "content": "lithium [SEP] port on the first part of our study of the effects of long-term lithium treatment on the kidney. Creatinine clearance, maximum urinary ", "tokenized_content": [2, 14330, 3, 9260, 1990, 1920, 2561, 3131, 1927, 2342, 2161, 1927, 1920, 2564, 1927, 2815, 17, 2576, 14330, 2311, 1990, 1920, 5245, 18, 9374, 7802, 16, 4419, 7075, 3]}, "items": [{"id": "p_4416", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_4417", "content": "Creatinine [SEP] dy of the effects of long-term lithium treatment on the kidney. Creatinine clearance, maximum urinary osmolality and 24 hour urine volume ", "tokenized_content": [2, 9374, 3, 6433, 1927, 1920, 2564, 1927, 2815, 17, 2576, 14330, 2311, 1990, 1920, 5245, 18, 9374, 7802, 16, 4419, 7075, 28854, 1930, 2686, 6231, 6960, 3776, 3]}, "items": [{"id": "p_4417", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_4418", "content": "Polyuria [SEP] The concentration defect appeared reversible, at least in part. Polyuria above 3 litres/24 hours was found in 10% of patients. An attemp", "tokenized_content": [2, 4286, 8754, 3, 1920, 3110, 7374, 6209, 10743, 16, 2019, 3464, 1922, 3131, 18, 4286, 8754, 3538, 23, 4471, 2808, 19, 2686, 3967, 1982, 2435, 1922, 2119, 9, 1927, 2132, 3]}, "items": [{"id": "p_4418", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_4419", "content": "heart block [SEP] Complete heart block following a single dose of trazodone.", "tokenized_content": [2, 4003, 3367, 3, 4080, 4003, 3367, 2894, 43, 2957, 3253, 1927, 3390, 13642, 28615, 1021, 18, 3]}, "items": [{"id": "p_4419", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_4420", "content": "trazodone [SEP] Complete heart block following a single dose of trazodone.", "tokenized_content": [2, 3390, 13642, 28615, 1021, 3, 4080, 4003, 3367, 2894, 43, 2957, 3253, 1927, 3390, 13642, 28615, 1021, 18, 3]}, "items": [{"id": "p_4420", "content": "Trazodone [SEP] A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major d", "score": 1, "type": null, "tokenized_content": [2, 3390, 13642, 28615, 1021, 3, 43, 11153, 5047, 4106, 1988, 1977, 2251, 1966, 1925, 11248, 2320, 5899, 18, 2176, 2258, 2252, 2522, 1942, 1998, 3655, 1922, 2132, 1956, 3044, 46, 3]}]}
{"query": {"id": "q_4421", "content": "trazodone [SEP] Forty minutes after receiving a single starting dose of trazodone, a patient developed complete heart block. The case illustrates", "tokenized_content": [2, 3390, 13642, 28615, 1021, 3, 11270, 4814, 2256, 5962, 43, 2957, 6801, 3253, 1927, 3390, 13642, 28615, 1021, 16, 43, 2774, 3530, 4080, 4003, 3367, 18, 1920, 3087, 11897, 3]}, "items": [{"id": "p_4421", "content": "Trazodone [SEP] A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major d", "score": 1, "type": null, "tokenized_content": [2, 3390, 13642, 28615, 1021, 3, 43, 11153, 5047, 4106, 1988, 1977, 2251, 1966, 1925, 11248, 2320, 5899, 18, 2176, 2258, 2252, 2522, 1942, 1998, 3655, 1922, 2132, 1956, 3044, 46, 3]}]}
{"query": {"id": "q_4422", "content": "heart block [SEP] single starting dose of trazodone, a patient developed complete heart block. The case illustrates that, despite the results of earlier stud", "tokenized_content": [2, 4003, 3367, 3, 2957, 6801, 3253, 1927, 3390, 13642, 28615, 1021, 16, 43, 2774, 3530, 4080, 4003, 3367, 18, 1920, 3087, 11897, 1988, 16, 4281, 1920, 2274, 1927, 5556, 2060, 3]}, "items": [{"id": "p_4422", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_4423", "content": "Quinidine phenylethylbarbiturate [SEP] Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report.", "tokenized_content": [2, 9012, 5802, 26939, 28935, 1024, 8751, 5443, 16082, 3, 9012, 5802, 26939, 28935, 1024, 8751, 5443, 16082, 17, 2719, 5257, 8547, 2031, 7977, 1922, 43, 7808, 10440, 18, 43, 3087, 3]}, "items": [{"id": "p_4423", "content": "phenobarbital quinidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 9012, 5802, 3, 3]}]}
{"query": {"id": "q_4424", "content": "hepatitis [SEP] Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report.", "tokenized_content": [2, 7977, 3, 9012, 5802, 26939, 28935, 1024, 8751, 5443, 16082, 17, 2719, 5257, 8547, 2031, 7977, 1922, 43, 7808, 10440, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4424", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4425", "content": "hepatitis [SEP] the case of a 19-year-old Laotian patient affected by fulminant hepatitis during the third trimester of her pregnancy after a 1-month adm", "tokenized_content": [2, 7977, 3, 1920, 3087, 1927, 43, 2282, 17, 2476, 17, 4156, 5114, 13323, 1928, 2774, 4218, 2007, 5257, 8547, 2031, 7977, 2409, 1920, 4563, 14315, 1927, 3656, 5284, 2256, 43, 3]}, "items": [{"id": "p_4425", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4426", "content": "quinidine phenylethylbarbiturate [SEP] rd trimester of her pregnancy after a 1-month administration of quinidine phenylethylbarbiturate. After delivery, the patient underwent orthotopic liver transpl", "tokenized_content": [2, 9012, 5802, 26939, 28935, 1024, 8751, 5443, 16082, 3, 8695, 14315, 1927, 3656, 5284, 2256, 43, 21, 17, 2935, 4183, 1927, 9012, 5802, 26939, 28935, 1024, 8751, 5443, 16082, 18, 3]}, "items": [{"id": "p_4426", "content": "phenobarbital quinidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 9012, 5802, 3, 3]}]}
{"query": {"id": "q_4427", "content": "Quinidine [SEP] nt was in good condition 16 months after liver transplantation. Quinidine itself or phenylethylbarbiturate may be responsible for fulmina", "tokenized_content": [2, 9012, 5802, 3, 5891, 1982, 1922, 4227, 2625, 2641, 3221, 2256, 3568, 6530, 18, 9012, 5802, 6999, 2014, 26939, 28935, 1024, 8751, 5443, 16082, 2278, 1998, 5061, 1958, 5257, 8547, 3]}, "items": [{"id": "p_4427", "content": "Quinidine [SEP] An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the", "score": 1, "type": null, "tokenized_content": [2, 9012, 5802, 3, 1925, 6322, 15348, 1927, 9012, 2053, 16, 5210, 2037, 1920, 18399, 1927, 1920, 6790, 28226, 2175, 6694, 1930, 2551, 4496, 3038, 18, 2052, 29951, 15515, 2099, 1920, 3]}]}
{"query": {"id": "q_4428", "content": "phenylethylbarbiturate [SEP] er of her pregnancy after a 1-month administration of quinidine phenylethylbarbiturate. After delivery, the patient underwent orthotopic liver transpl", "tokenized_content": [2, 26939, 28935, 1024, 8751, 5443, 16082, 3, 2668, 1927, 3656, 5284, 2256, 43, 21, 17, 2935, 4183, 1927, 9012, 5802, 26939, 28935, 1024, 8751, 5443, 16082, 18, 2256, 4868, 16, 3]}, "items": [{"id": "p_4428", "content": "phenobarbital quinidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 9012, 5802, 3, 3]}]}
{"query": {"id": "q_4429", "content": "flank pain [SEP] The epidemiology of the acute flank pain syndrome from suprofen.", "tokenized_content": [2, 9199, 3594, 3, 1920, 11683, 1927, 1920, 3939, 9199, 3594, 4741, 2037, 9320, 18514, 18, 3]}, "items": [{"id": "p_4429", "content": "Flank Pain [SEP] Pain emanating from below the RIBS and above the ILIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9199, 3594, 3, 3594, 27436, 2287, 2037, 4535, 1920, 5216, 1036, 1930, 3538, 1920, 14872, 1989, 18, 3]}]}
{"query": {"id": "q_4430", "content": "suprofen [SEP] The epidemiology of the acute flank pain syndrome from suprofen.", "tokenized_content": [2, 9320, 18514, 3, 1920, 11683, 1927, 1920, 3939, 9199, 3594, 4741, 2037, 9320, 18514, 18, 3]}, "items": [{"id": "p_4430", "content": "Suprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an a", "score": 1, "type": null, "tokenized_content": [2, 9320, 18514, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 7042, 15900, 4271, 1930, 2258, 2252, 4211, 1966, 1925, 43, 3]}]}
{"query": {"id": "q_4431", "content": "Suprofen [SEP] Suprofen, a new nonsteroidal anti-inflammatory drug, was marketed in ear", "tokenized_content": [2, 9320, 18514, 3, 9320, 18514, 16, 43, 2814, 29413, 2246, 17, 3769, 2838, 16, 1982, 28392, 1922, 4352, 3]}, "items": [{"id": "p_4431", "content": "Suprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an a", "score": 1, "type": null, "tokenized_content": [2, 9320, 18514, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 7042, 15900, 4271, 1930, 2258, 2252, 4211, 1966, 1925, 43, 3]}]}
{"query": {"id": "q_4432", "content": "flank pain [SEP] lgesic agent. Until physicians began reporting an unusual acute flank pain syndrome to the spontaneous reporting system, 700,000 persons u", "tokenized_content": [2, 9199, 3594, 3, 28816, 12924, 1030, 5899, 18, 4801, 6967, 10486, 6605, 1925, 12236, 3939, 9199, 3594, 4741, 1942, 1920, 6242, 6605, 2433, 16, 11851, 16, 3240, 7618, 63, 3]}, "items": [{"id": "p_4432", "content": "Flank Pain [SEP] Pain emanating from below the RIBS and above the ILIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9199, 3594, 3, 3594, 27436, 2287, 2037, 4535, 1920, 5216, 1036, 1930, 3538, 1920, 14872, 1989, 18, 3]}]}
{"query": {"id": "q_4433", "content": "suprofen [SEP] ho had been reported to the spontaneous reporting system to 185 suprofen-exposed control subjects who did not have the syndrome. Case pa", "tokenized_content": [2, 9320, 18514, 3, 6673, 2430, 2252, 2568, 1942, 1920, 6242, 6605, 2433, 1942, 15659, 9320, 18514, 17, 4616, 2285, 3297, 2746, 2811, 2084, 2162, 1920, 4741, 18, 3087, 3838, 3]}, "items": [{"id": "p_4433", "content": "Suprofen [SEP] An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an a", "score": 1, "type": null, "tokenized_content": [2, 9320, 18514, 3, 1925, 24089, 17, 2601, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 18, 2176, 7042, 15900, 4271, 1930, 2258, 2252, 4211, 1966, 1925, 43, 3]}]}
{"query": {"id": "q_4434", "content": "hay fever [SEP] dds ratio, 3.8; 95% confidence interval, 1.2-12.1), suffer from hay fever and asthma (odds ratio, 3.4; 95% confidence interval, 1.0-11.9)", "tokenized_content": [2, 15568, 9087, 3, 6758, 1036, 3400, 16, 23, 18, 28, 31, 3002, 9, 5203, 4979, 16, 21, 18, 22, 17, 2369, 18, 21, 13, 16, 7416, 2037, 15568, 9087, 1930, 3]}, "items": [{"id": "p_4434", "content": "Rhinitis, Allergic, Seasonal [SEP] Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCH", "score": 1, "type": null, "tokenized_content": [2, 21298, 16, 10519, 16, 10995, 3, 10519, 21298, 1988, 5110, 2019, 1920, 2841, 2367, 4808, 2476, 18, 2176, 1977, 4378, 2007, 3939, 16911, 3678, 1956, 26919, 12874, 1929, 1930, 20687, 3]}]}
{"query": {"id": "q_4435", "content": "asthma [SEP] ; 95% confidence interval, 1.2-12.1), suffer from hay fever and asthma (odds ratio, 3.4; 95% confidence interval, 1.0-11.9); to partic", "tokenized_content": [2, 6678, 3, 31, 3002, 9, 5203, 4979, 16, 21, 18, 22, 17, 2369, 18, 21, 13, 16, 7416, 2037, 15568, 9087, 1930, 6678, 12, 6408, 3400, 16, 23, 18, 24, 3]}, "items": [{"id": "p_4435", "content": "Asthma [SEP] A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway ", "score": 1, "type": null, "tokenized_content": [2, 6678, 3, 43, 2386, 1927, 14700, 4770, 1956, 2559, 4493, 4178, 30, 8155, 4194, 17, 10854, 12, 5481, 14625, 13, 16, 8155, 3]}]}
{"query": {"id": "q_4436", "content": "alcohol [SEP] ecially in the use of Nautilus equipment (p = 0.02); and to use alcohol (odds ratio, 4.4; 95% confidence interval, 1.1-17.5). Possible ", "tokenized_content": [2, 4284, 3, 3270, 3799, 1922, 1920, 2485, 1927, 4049, 1984, 1970, 1957, 11166, 12, 58, 33, 20, 18, 5725, 13, 31, 1930, 1942, 2485, 4284, 12, 6408, 3400, 16, 24, 3]}, "items": [{"id": "p_4436", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_4437", "content": "ibuprofen [SEP] young age, concurrent use of other analgesic agents (especially ibuprofen), preexisting renal disease, a history of kidney stones, a hist", "tokenized_content": [2, 24089, 3, 4201, 2632, 16, 10391, 2485, 1927, 2303, 14501, 4820, 12, 4369, 24089, 13, 16, 21604, 4604, 2573, 16, 43, 4403, 1927, 5245, 18183, 16, 43, 2968, 3]}, "items": [{"id": "p_4437", "content": "Ibuprofen [SEP] A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24089, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 14501, 3879, 2251, 1922, 1920, 3181, 1927, 10939, 2421, 1930, 8884, 18, 3]}]}
{"query": {"id": "q_4438", "content": "renal disease [SEP] e of other analgesic agents (especially ibuprofen), preexisting renal disease, a history of kidney stones, a history of gout, a recent increa", "tokenized_content": [2, 4604, 2573, 3, 47, 1927, 2303, 14501, 4820, 12, 4369, 24089, 13, 16, 21604, 4604, 2573, 16, 43, 4403, 1927, 5245, 18183, 16, 43, 4403, 1927, 22952, 16, 43, 3505, 3]}, "items": [{"id": "p_4438", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4439", "content": "kidney stones [SEP] (especially ibuprofen), preexisting renal disease, a history of kidney stones, a history of gout, a recent increase in activity, a recent inc", "tokenized_content": [2, 5245, 18183, 3, 12, 4369, 24089, 13, 16, 21604, 4604, 2573, 16, 43, 4403, 1927, 5245, 18183, 16, 43, 4403, 1927, 22952, 16, 43, 3505, 2760, 1922, 2455, 16, 43, 3]}, "items": [{"id": "p_4439", "content": "Kidney Calculi [SEP] Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most conta", "score": 1, "type": null, "tokenized_content": [2, 5245, 2799, 13004, 3, 18183, 1922, 1920, 5245, 16, 5394, 5333, 1922, 1920, 6960, 17, 13607, 3403, 1927, 1920, 5245, 12, 5245, 18152, 13, 18, 2310, 6562, 5304, 1930, 2501, 2120, 1019, 3]}]}
{"query": {"id": "q_4440", "content": "gout [SEP] xisting renal disease, a history of kidney stones, a history of gout, a recent increase in activity, a recent increase in sun exposu", "tokenized_content": [2, 22952, 3, 29300, 1941, 4604, 2573, 16, 43, 4403, 1927, 5245, 18183, 16, 43, 4403, 1927, 22952, 16, 43, 3505, 2760, 1922, 2455, 16, 43, 3505, 2760, 1922, 8147, 2938, 3]}, "items": [{"id": "p_4440", "content": "Gout [SEP] Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and ar", "score": 1, "type": null, "tokenized_content": [2, 22952, 3, 16321, 4487, 4770, 4378, 2007, 7457, 3939, 8884, 16, 4194, 15861, 3847, 1930, 7860, 1927, 5227, 3674, 2010, 1922, 1930, 2245, 3]}]}
{"query": {"id": "q_4441", "content": "uric acid [SEP] ism for this unusual syndrome: acute diffuse crystallization of uric acid in renal tubules.", "tokenized_content": [2, 17607, 2687, 3, 1977, 1035, 1958, 2052, 12236, 4741, 30, 3939, 9435, 15416, 1927, 17607, 2687, 1922, 4604, 14876, 18, 3]}, "items": [{"id": "p_4441", "content": "Uric Acid [SEP] An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product o", "score": 1, "type": null, "tokenized_content": [2, 17607, 2687, 3, 1925, 6638, 4863, 16, 3454, 26059, 10488, 16, 1927, 20004, 1034, 17687, 1036, 2427, 1966, 26059, 1930, 5918, 24943, 18, 2176, 1977, 1920, 3948, 6638, 4863, 57, 3]}]}
{"query": {"id": "q_4442", "content": "Hemolytic-uremic syndrome [SEP] Hemolytic-uremic syndrome associated with ingestion of quinine.", "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 21515, 17, 29870, 4741, 2458, 1956, 14195, 1927, 9012, 2053, 18, 3]}, "items": [{"id": "p_4442", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_4443", "content": "quinine [SEP] Hemolytic-uremic syndrome associated with ingestion of quinine.", "tokenized_content": [2, 9012, 2053, 3, 21515, 17, 29870, 4741, 2458, 1956, 14195, 1927, 9012, 2053, 18, 3]}, "items": [{"id": "p_4443", "content": "Quinine [SEP] An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extr", "score": 1, "type": null, "tokenized_content": [2, 9012, 2053, 3, 1925, 29951, 3595, 2037, 1920, 18399, 1927, 1920, 10510, 28226, 2175, 6694, 18, 2176, 1977, 2251, 1966, 1925, 27290, 2838, 16, 1930, 1977, 1920, 3500, 24364, 1922, 2821, 3]}]}
{"query": {"id": "q_4444", "content": "Hemolytic-uremic syndrome [SEP] Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, wi", "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 21515, 17, 29870, 4741, 2894, 9012, 2053, 14195, 1977, 43, 7471, 2910, 7902, 16, 11980, 3]}, "items": [{"id": "p_4444", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_4445", "content": "quinine [SEP] Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, with just two previo", "tokenized_content": [2, 9012, 2053, 3, 21515, 17, 29870, 4741, 2894, 9012, 2053, 14195, 1977, 43, 7471, 2910, 7902, 16, 1956, 6244, 2288, 2817, 3940, 3]}, "items": [{"id": "p_4445", "content": "Quinine [SEP] An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extr", "score": 1, "type": null, "tokenized_content": [2, 9012, 2053, 3, 1925, 29951, 3595, 2037, 1920, 18399, 1927, 1920, 10510, 28226, 2175, 6694, 18, 2176, 1977, 2251, 1966, 1925, 27290, 2838, 16, 1930, 1977, 1920, 3500, 24364, 1922, 2821, 3]}]}
{"query": {"id": "q_4446", "content": "prednisone [SEP] ence of quinine. Treatment has included use of plasma exchange, prednisone, aspirin, and dipyridamole. The patients have all regained some", "tokenized_content": [2, 20405, 3, 3350, 1021, 1927, 9012, 2053, 18, 2311, 2258, 3063, 2485, 1927, 3582, 6818, 16, 20405, 16, 12396, 16, 1930, 9137, 3553, 9532, 12492, 1952, 18, 1920, 2132, 2162, 3]}, "items": [{"id": "p_4446", "content": "Prednisone [SEP] A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in t", "score": 1, "type": null, "tokenized_content": [2, 20405, 3, 43, 6830, 2246, 17, 3769, 14469, 3595, 2037, 18964, 8142, 1021, 18, 2176, 1977, 12186, 22937, 1930, 9076, 1942, 22025, 1922, 62, 3]}]}
{"query": {"id": "q_4447", "content": "aspirin [SEP] ine. Treatment has included use of plasma exchange, prednisone, aspirin, and dipyridamole. The patients have all regained some degree o", "tokenized_content": [2, 12396, 3, 11116, 18, 2311, 2258, 3063, 2485, 1927, 3582, 6818, 16, 20405, 16, 12396, 16, 1930, 9137, 3553, 9532, 12492, 1952, 18, 1920, 2132, 2162, 2136, 2147, 2368, 2673, 3]}, "items": [{"id": "p_4447", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4448", "content": "dipyridamole [SEP] t has included use of plasma exchange, prednisone, aspirin, and dipyridamole. The patients have all regained some degree of renal function. ", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 62, 2258, 3063, 2485, 1927, 3582, 6818, 16, 20405, 16, 12396, 16, 1930, 9137, 3553, 9532, 12492, 1952, 18, 1920, 2132, 2162, 2136, 2147, 3]}, "items": [{"id": "p_4448", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_4449", "content": "Quinine [SEP] t or spontaneous resolution is responsible for the improvement. Quinine-associated hemolytic-uremic syndrome probably occurs more often", "tokenized_content": [2, 9012, 2053, 3, 62, 2014, 6242, 4885, 1977, 5061, 1958, 1920, 4990, 18, 9012, 2053, 17, 2458, 21515, 17, 29870, 4741, 6226, 5110, 2253, 3868, 3]}, "items": [{"id": "p_4449", "content": "Quinine [SEP] An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extr", "score": 1, "type": null, "tokenized_content": [2, 9012, 2053, 3, 1925, 29951, 3595, 2037, 1920, 18399, 1927, 1920, 10510, 28226, 2175, 6694, 18, 2176, 1977, 2251, 1966, 1925, 27290, 2838, 16, 1930, 1977, 1920, 3500, 24364, 1922, 2821, 3]}]}
{"query": {"id": "q_4450", "content": "hemolytic-uremic syndrome [SEP] solution is responsible for the improvement. Quinine-associated hemolytic-uremic syndrome probably occurs more often than is recognized. It is important ", "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 3331, 1977, 5061, 1958, 1920, 4990, 18, 9012, 2053, 17, 2458, 21515, 17, 29870, 4741, 6226, 5110, 2253, 3868, 2254, 1977, 6783, 18, 2176, 1977, 3]}, "items": [{"id": "p_4450", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_4451", "content": "pyeloureteritis cystica [SEP] The etiology of pyeloureteritis cystica has long been attributed to chronic infection and inflammation.", "tokenized_content": [2, 6085, 1938, 2257, 2732, 3678, 11656, 1019, 3, 1920, 10383, 1927, 6085, 1938, 2257, 2732, 3678, 11656, 1019, 2258, 2815, 2252, 6898, 1942, 3724, 2909, 1930, 4531, 18, 3]}, "items": [{"id": "p_4451", "content": "Pyelitis [SEP] Inflammation of the KIDNEY PELVIS and KIDNEY CALICES where urine is collected before discharge, but does not involve the renal p", "score": 1, "type": null, "tokenized_content": [2, 6085, 11085, 3600, 3, 4531, 1927, 1920, 5245, 18152, 1930, 5245, 2570, 3590, 2597, 6960, 1977, 3651, 3119, 7695, 16, 2308, 3731, 2084, 8156, 1920, 4604, 58, 3]}]}
{"query": {"id": "q_4452", "content": "infection [SEP]  of pyeloureteritis cystica has long been attributed to chronic infection and inflammation. A case is presented that is unique in that th", "tokenized_content": [2, 2909, 3, 1927, 6085, 1938, 2257, 2732, 3678, 11656, 1019, 2258, 2815, 2252, 6898, 1942, 3724, 2909, 1930, 4531, 18, 43, 3087, 1977, 3549, 1988, 1977, 5008, 1922, 1988, 1913, 3]}, "items": [{"id": "p_4452", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_4453", "content": "inflammation [SEP] ritis cystica has long been attributed to chronic infection and inflammation. A case is presented that is unique in that the acute onset and", "tokenized_content": [2, 4531, 3, 24019, 1937, 11656, 1019, 2258, 2815, 2252, 6898, 1942, 3724, 2909, 1930, 4531, 18, 43, 3087, 1977, 3549, 1988, 1977, 5008, 1922, 1988, 1920, 3939, 4727, 1930, 3]}, "items": [{"id": "p_4453", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_4454", "content": "heparin [SEP] s patient. The disease occurred subsequent to the initiation of heparin therapy for suspected pelvic thrombophlebitis and cleared rapid", "tokenized_content": [2, 9962, 3, 61, 2774, 18, 1920, 2573, 4807, 4521, 1942, 1920, 6035, 1927, 9962, 3181, 1958, 9407, 10953, 16379, 2102, 1952, 5443, 1937, 1930, 15392, 4052, 3]}, "items": [{"id": "p_4454", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4455", "content": "thrombophlebitis [SEP] quent to the initiation of heparin therapy for suspected pelvic thrombophlebitis and cleared rapidly subsequent to its discontinuation. The rate", "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 10730, 4905, 1942, 1920, 6035, 1927, 9962, 3181, 1958, 9407, 10953, 16379, 2102, 1952, 5443, 1937, 1930, 15392, 6221, 4521, 1942, 2496, 14775, 18, 3]}, "items": [{"id": "p_4455", "content": "Thrombophlebitis [SEP] Inflammation of a vein associated with a blood clot (THROMBUS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 4531, 1927, 43, 7920, 2458, 1956, 43, 2877, 15053, 12, 16705, 13, 18, 3]}]}
{"query": {"id": "q_4456", "content": "submucosal hemorrhage [SEP] pful in distinguishing between true pyeloureteritis cystica and submucosal hemorrhage.", "tokenized_content": [2, 24298, 10489, 3, 17356, 1024, 1922, 15589, 2192, 6228, 6085, 1938, 2257, 2732, 3678, 11656, 1019, 1930, 24298, 10489, 18, 3]}, "items": [{"id": "p_4456", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4457", "content": "hepatoma [SEP] Changes in peroxisomes in preneoplastic liver and hepatoma of mice induced by alpha-benzene hexachloride.", "tokenized_content": [2, 23980, 3, 2840, 1922, 28990, 1922, 9972, 1021, 9969, 3568, 1930, 23980, 1927, 2518, 2719, 2007, 4595, 17, 18536, 7142, 22918, 2261, 18, 3]}, "items": [{"id": "p_4457", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_4458", "content": "alpha-benzene hexachloride [SEP] oxisomes in preneoplastic liver and hepatoma of mice induced by alpha-benzene hexachloride.", "tokenized_content": [2, 4595, 17, 18536, 7142, 22918, 2261, 3, 2833, 23854, 21085, 1922, 9972, 1021, 9969, 3568, 1930, 23980, 1927, 2518, 2719, 2007, 4595, 17, 18536, 7142, 22918, 2261, 18, 3]}, "items": [{"id": "p_4458", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_4459", "content": "hepatomas [SEP] Peroxisomes in hepatomas and hyperplastic preneoplastic liver lesions induced in mice by", "tokenized_content": [2, 23980, 1036, 3, 28990, 1922, 23980, 1036, 1930, 28733, 9972, 1021, 9969, 3568, 4518, 2719, 1922, 2518, 2007, 3]}, "items": [{"id": "p_4459", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_4460", "content": "liver lesions [SEP] Peroxisomes in hepatomas and hyperplastic preneoplastic liver lesions induced in mice by 500 ppm alpha-benzene hexachloride were exam", "tokenized_content": [2, 3568, 4518, 3, 28990, 1922, 23980, 1036, 1930, 28733, 9972, 1021, 9969, 3568, 4518, 2719, 1922, 2518, 2007, 4599, 8748, 4595, 17, 18536, 7142, 22918, 2261, 1985, 2493, 3]}, "items": [{"id": "p_4460", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_4461", "content": "alpha-benzene hexachloride [SEP] rplastic preneoplastic liver lesions induced in mice by 500 ppm alpha-benzene hexachloride were examined histochemically and electron microscopically. Alt", "tokenized_content": [2, 4595, 17, 18536, 7142, 22918, 2261, 3, 17297, 4054, 9972, 1021, 9969, 3568, 4518, 2719, 1922, 2518, 2007, 4599, 8748, 4595, 17, 18536, 7142, 22918, 2261, 1985, 3572, 27816, 1954, 3]}, "items": [{"id": "p_4461", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_4462", "content": "tumors [SEP] ically. Although most of the hepatomas were well-differentiated tumors and contained a considerable number of peroxisomes, the tumor c", "tokenized_content": [2, 3861, 3, 14784, 11560, 1012, 18, 2876, 2501, 1927, 1920, 23980, 1036, 1985, 2486, 17, 7512, 3861, 1930, 5543, 43, 7743, 2529, 1927, 28990, 16, 1920, 2798, 45, 3]}, "items": [{"id": "p_4462", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4463", "content": "tumor [SEP] ically. Although most of the hepatomas were well-differentiated tumors and contained a considerable number of peroxisomes, the tumor ", "tokenized_content": [2, 2798, 3, 14784, 11560, 1012, 18, 2876, 2501, 1927, 1920, 23980, 1036, 1985, 2486, 17, 7512, 3861, 1930, 5543, 43, 7743, 2529, 1927, 28990, 16, 1920, 2798, 3]}, "items": [{"id": "p_4463", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4464", "content": "ethyl-alpha-p-chlorophenoxyisobutyrate [SEP] rable number of peroxisomes, the tumor cells did not respond to ethyl-alpha-p-chlorophenoxyisobutyrate with proliferation of peroxisomes. At the 16th week of carcinog", "tokenized_content": [2, 7843, 17, 4595, 17, 58, 17, 10107, 17616, 7221, 23854, 16119, 16128, 3, 4673, 1952, 2529, 1927, 28990, 16, 1920, 2798, 2094, 2811, 2084, 4409, 1942, 7843, 17, 4595, 17, 3]}, "items": [{"id": "p_4464", "content": "beta-diethylaminoethyl alpha-4-chlorophenoxyisobutyrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 18622, 19143, 5188, 4595, 17, 24, 17, 10107, 17616, 7221, 23854, 16119, 16128, 3, 3]}]}
{"query": {"id": "q_4465", "content": "Quinidine [SEP] Quinidine hepatitis.", "tokenized_content": [2, 9012, 5802, 3, 9012, 5802, 7977, 18, 3]}, "items": [{"id": "p_4465", "content": "Quinidine [SEP] An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the", "score": 1, "type": null, "tokenized_content": [2, 9012, 5802, 3, 1925, 6322, 15348, 1927, 9012, 2053, 16, 5210, 2037, 1920, 18399, 1927, 1920, 6790, 28226, 2175, 6694, 1930, 2551, 4496, 3038, 18, 2052, 29951, 15515, 2099, 1920, 3]}]}
{"query": {"id": "q_4466", "content": "hepatitis [SEP] Quinidine hepatitis.", "tokenized_content": [2, 7977, 3, 9012, 5802, 7977, 18, 3]}, "items": [{"id": "p_4466", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4467", "content": "quinidine [SEP] Long-term administration of quinidine was associated with persistent elevation of serum concentration", "tokenized_content": [2, 9012, 5802, 3, 2815, 17, 2576, 4183, 1927, 9012, 5802, 1982, 2458, 1956, 7733, 8644, 1927, 3256, 3110, 3]}, "items": [{"id": "p_4467", "content": "Quinidine [SEP] An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the", "score": 1, "type": null, "tokenized_content": [2, 9012, 5802, 3, 1925, 6322, 15348, 1927, 9012, 2053, 16, 5210, 2037, 1920, 18399, 1927, 1920, 6790, 28226, 2175, 6694, 1930, 2551, 4496, 3038, 18, 2052, 29951, 15515, 2099, 1920, 3]}]}
{"query": {"id": "q_4468", "content": "lactic acid [SEP] ated with persistent elevation of serum concentrations of SGOT, lactic acid dehydrogenase, and alkaline phosphatase. Liver biopsy showed ac", "tokenized_content": [2, 16562, 2687, 3, 30280, 1007, 1956, 7733, 8644, 1927, 3256, 3295, 1927, 10075, 1991, 16, 16562, 2687, 9294, 16, 1930, 10746, 8167, 18, 3568, 6831, 2594, 2000, 3]}, "items": [{"id": "p_4468", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_4469", "content": "hepatitis [SEP] drogenase, and alkaline phosphatase. Liver biopsy showed active hepatitis. Discontinuance of quinidine therapy led to normalization of li", "tokenized_content": [2, 7977, 3, 8442, 2432, 2051, 16, 1930, 10746, 8167, 18, 3568, 6831, 2594, 3500, 7977, 18, 9035, 13785, 1972, 1927, 9012, 5802, 3181, 4866, 1942, 10413, 1927, 2336, 3]}, "items": [{"id": "p_4469", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4470", "content": "hepatotoxicity [SEP] ydrogenase values. We concluded that this patient had quinidine hepatotoxicity and believe that this is the first case reported with liver bio", "tokenized_content": [2, 24126, 3, 67, 3883, 2404, 2051, 2851, 18, 2038, 7903, 1988, 2052, 2774, 2430, 9012, 5802, 24126, 1930, 9129, 1988, 2052, 1977, 1920, 2561, 3087, 2568, 1956, 3568, 3718, 3]}, "items": [{"id": "p_4470", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4471", "content": "hepatic toxicity [SEP] rt also suggests that, even after long-term administration, the hepatic toxicity is reversible.", "tokenized_content": [2, 6095, 5532, 3, 4341, 2222, 4015, 1988, 16, 3385, 2256, 2815, 17, 2576, 4183, 16, 1920, 6095, 5532, 1977, 10743, 18, 3]}, "items": [{"id": "p_4471", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4472", "content": "Cholesteryl hemisuccinate [SEP] Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminop", "tokenized_content": [2, 21211, 2734, 1024, 28881, 20490, 2437, 5661, 3, 21211, 2734, 1024, 28881, 20490, 2437, 5661, 2311, 14576, 12035, 2037, 1920, 6161, 2564, 1927, 4118, 19143, 1034, 3]}, "items": [{"id": "p_4472", "content": "cholesteryl succinate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21211, 2734, 1024, 19234, 3, 3]}]}
{"query": {"id": "q_4473", "content": "acetaminophen [SEP] isuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine", "tokenized_content": [2, 23311, 3, 1977, 27186, 2010, 2311, 14576, 12035, 2037, 1920, 6161, 2564, 1927, 23311, 16, 25622, 7898, 16, 5056, 12470, 11600, 2261, 16, 13987, 1930, 9479, 17454, 3]}, "items": [{"id": "p_4473", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4474", "content": "adriamycin [SEP] tment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.", "tokenized_content": [2, 25622, 7898, 3, 22377, 4905, 14576, 12035, 2037, 1920, 6161, 2564, 1927, 23311, 16, 25622, 7898, 16, 5056, 12470, 11600, 2261, 16, 13987, 1930, 9479, 17454, 18, 3]}, "items": [{"id": "p_4474", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4475", "content": "carbon tetrachloride [SEP] ts rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.", "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 4894, 12035, 2037, 1920, 6161, 2564, 1927, 23311, 16, 25622, 7898, 16, 5056, 12470, 11600, 2261, 16, 13987, 1930, 9479, 17454, 18, 3]}, "items": [{"id": "p_4475", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_4476", "content": "chloroform [SEP] xic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.", "tokenized_content": [2, 13987, 3, 11551, 1030, 2564, 1927, 23311, 16, 25622, 7898, 16, 5056, 12470, 11600, 2261, 16, 13987, 1930, 9479, 17454, 18, 3]}, "items": [{"id": "p_4476", "content": "Chloroform [SEP] A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its susp", "score": 1, "type": null, "tokenized_content": [2, 13987, 3, 43, 5384, 2251, 4542, 7596, 18, 2176, 1982, 3024, 2251, 1966, 1925, 16111, 16, 2308, 1982, 15114, 5300, 2037, 2485, 1922, 1920, 63, 18, 61, 18, 2810, 1942, 2496, 4940, 3]}]}
{"query": {"id": "q_4477", "content": "galactosamine [SEP] acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.", "tokenized_content": [2, 9479, 17454, 3, 23311, 16, 25622, 7898, 16, 5056, 12470, 11600, 2261, 16, 13987, 1930, 9479, 17454, 18, 3]}, "items": [{"id": "p_4477", "content": "Galactosamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9479, 17454, 3, 3]}]}
{"query": {"id": "q_4478", "content": "cholesteryl hemisuccinate [SEP] In addition to its use as a stabilizer/rigidifier of membranes, cholesteryl hemisuccinate, tris salt (CS) administration has also been shown to protect r", "tokenized_content": [2, 21211, 2734, 1024, 28881, 20490, 2437, 5661, 3, 1922, 2459, 1942, 2496, 2485, 1966, 43, 13448, 1005, 19, 12383, 9872, 1927, 5726, 16, 21211, 2734, 1024, 28881, 20490, 2437, 5661, 3]}, "items": [{"id": "p_4478", "content": "cholesteryl succinate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21211, 2734, 1024, 19234, 3, 3]}]}
{"query": {"id": "q_4479", "content": "hepatotoxic [SEP] CS) administration has also been shown to protect rats from the hepatotoxic effects of carbon tetrachloride (CCl4). To further our understa", "tokenized_content": [2, 5746, 12899, 3, 3752, 13, 4183, 2258, 2222, 2252, 2522, 1942, 9145, 3615, 2037, 1920, 5746, 12899, 2564, 1927, 5056, 12470, 11600, 2261, 12, 20786, 13, 18, 1942, 2520, 2342, 3]}, "items": [{"id": "p_4479", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4480", "content": "carbon tetrachloride [SEP] also been shown to protect rats from the hepatotoxic effects of carbon tetrachloride (CCl4). To further our understanding of the mechanism of CS cyt", "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 2222, 2252, 2522, 1942, 9145, 3615, 2037, 1920, 5746, 12899, 2564, 1927, 5056, 12470, 11600, 2261, 12, 20786, 13, 18, 1942, 2520, 2342, 4339, 1927, 3]}, "items": [{"id": "p_4480", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_4481", "content": "CCl4 [SEP] tect rats from the hepatotoxic effects of carbon tetrachloride (CCl4). To further our understanding of the mechanism of CS cytoprote", "tokenized_content": [2, 20786, 3, 18671, 1031, 3615, 2037, 1920, 5746, 12899, 2564, 1927, 5056, 12470, 11600, 2261, 12, 20786, 13, 18, 1942, 2520, 2342, 4339, 1927, 1920, 2856, 1927, 3752, 22953, 9218, 3]}, "items": [{"id": "p_4481", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_4482", "content": "gamma-cholesteryloxybutyric acid [SEP] tive abilities of CS and the non-hydrolyzable ether form of CS, gamma-cholesteryloxybutyric acid, tris salt (CSE) against acetaminophen-, adriamycin-, carbon te", "tokenized_content": [2, 7034, 17, 21211, 2734, 6012, 10465, 16119, 19872, 2687, 3, 8685, 1961, 10957, 1927, 3752, 1930, 1920, 2447, 17, 7222, 12813, 7272, 14121, 2386, 1927, 3752, 16, 7034, 17, 21211, 3]}, "items": [{"id": "p_4482", "content": "4-(cholesteryloxy)butyric acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 12, 21211, 2734, 6012, 10465, 13, 2308, 19872, 2687, 3, 3]}]}
{"query": {"id": "q_4483", "content": "acetaminophen [SEP] f CS, gamma-cholesteryloxybutyric acid, tris salt (CSE) against acetaminophen-, adriamycin-, carbon tetrachloride-, chloroform- and galactosa", "tokenized_content": [2, 23311, 3, 48, 3752, 16, 7034, 17, 21211, 2734, 6012, 10465, 16119, 19872, 2687, 16, 6349, 7012, 12, 21606, 13, 3316, 23311, 17, 16, 25622, 7898, 17, 16, 5056, 12470, 3]}, "items": [{"id": "p_4483", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4484", "content": "adriamycin [SEP] esteryloxybutyric acid, tris salt (CSE) against acetaminophen-, adriamycin-, carbon tetrachloride-, chloroform- and galactosamine-induced ", "tokenized_content": [2, 25622, 7898, 3, 9603, 2199, 7221, 16119, 19872, 2687, 16, 6349, 7012, 12, 21606, 13, 3316, 23311, 17, 16, 25622, 7898, 17, 16, 5056, 12470, 11600, 2261, 17, 16, 13987, 3]}, "items": [{"id": "p_4484", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4485", "content": "chloroform [SEP] SE) against acetaminophen-, adriamycin-, carbon tetrachloride-, chloroform- and galactosamine-induced toxicity. The results of these studi", "tokenized_content": [2, 13987, 3, 2058, 13, 3316, 23311, 17, 16, 25622, 7898, 17, 16, 5056, 12470, 11600, 2261, 17, 16, 13987, 17, 1930, 9479, 17454, 17, 2719, 5532, 18, 1920, 2274, 1927, 3]}, "items": [{"id": "p_4485", "content": "Chloroform [SEP] A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its susp", "score": 1, "type": null, "tokenized_content": [2, 13987, 3, 43, 5384, 2251, 4542, 7596, 18, 2176, 1982, 3024, 2251, 1966, 1925, 16111, 16, 2308, 1982, 15114, 5300, 2037, 2485, 1922, 1920, 63, 18, 61, 18, 2810, 1942, 2496, 4940, 3]}]}
{"query": {"id": "q_4486", "content": "galactosamine [SEP] aminophen-, adriamycin-, carbon tetrachloride-, chloroform- and galactosamine-induced toxicity. The results of these studies demonstrated tha", "tokenized_content": [2, 9479, 17454, 3, 3835, 17616, 17, 16, 25622, 7898, 17, 16, 5056, 12470, 11600, 2261, 17, 16, 13987, 17, 1930, 9479, 17454, 17, 2719, 5532, 18, 1920, 2274, 1927, 2144, 3]}, "items": [{"id": "p_4486", "content": "Galactosamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9479, 17454, 3, 3]}]}
{"query": {"id": "q_4487", "content": "toxicity [SEP] -, carbon tetrachloride-, chloroform- and galactosamine-induced toxicity. The results of these studies demonstrated that CS-mediated pro", "tokenized_content": [2, 5532, 3, 17, 16, 5056, 12470, 11600, 2261, 17, 16, 13987, 17, 1930, 9479, 17454, 17, 2719, 5532, 18, 1920, 2274, 1927, 2144, 2351, 3161, 1988, 3752, 17, 3434, 1965, 3]}, "items": [{"id": "p_4487", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4488", "content": "CHCl3 [SEP] significant protection against the hepatotoxic effects of CCl4, CHCl3, acetaminophen and galactosamine and against the lethal (and pr", "tokenized_content": [2, 26863, 3, 2228, 6202, 3316, 1920, 5746, 12899, 2564, 1927, 20786, 16, 26863, 16, 23311, 1930, 9479, 17454, 1930, 3316, 1920, 10470, 12, 1930, 2033, 3]}, "items": [{"id": "p_4488", "content": "Chloroform [SEP] A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its susp", "score": 1, "type": null, "tokenized_content": [2, 13987, 3, 43, 5384, 2251, 4542, 7596, 18, 2176, 1982, 3024, 2251, 1966, 1925, 16111, 16, 2308, 1982, 15114, 5300, 2037, 2485, 1922, 1920, 63, 18, 61, 18, 2810, 1942, 2496, 4940, 3]}]}
{"query": {"id": "q_4489", "content": "cardiotoxic [SEP] nophen and galactosamine and against the lethal (and presumably cardiotoxic) effect of adriamycin administration. Maximal CS-mediated prote", "tokenized_content": [2, 21129, 4575, 18068, 1030, 3, 30272, 22467, 1930, 9479, 17454, 1930, 3316, 1920, 10470, 12, 1930, 9968, 21129, 4575, 18068, 1030, 13, 2495, 1927, 25622, 7898, 4183, 18, 7275, 3752, 3]}, "items": [{"id": "p_4489", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4490", "content": "hepatotoxicity [SEP] iate (in light of the protection observed against galactosamine hepatotoxicity). However, based on the data presented, we can not exclude the ", "tokenized_content": [2, 24126, 3, 21006, 1021, 12, 1922, 3696, 1927, 1920, 6202, 2528, 3316, 9479, 17454, 24126, 13, 18, 2406, 16, 2454, 1990, 1920, 2230, 3549, 16, 2038, 2112, 2084, 10443, 1920, 3]}, "items": [{"id": "p_4490", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4491", "content": "cyclophosphamide [SEP] DSMM XI study: dose definition for intravenous cyclophosphamide in combination with bortezomib/dexamethasone for remission indu", "tokenized_content": [2, 17135, 3, 10964, 1035, 11551, 2161, 30, 3253, 6600, 1958, 7307, 17135, 1922, 3921, 1956, 18632, 19, 12681, 1958, 10221, 2063, 1032, 3]}, "items": [{"id": "p_4491", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4492", "content": "bortezomib [SEP] definition for intravenous cyclophosphamide in combination with bortezomib/dexamethasone for remission induction in patients with newly di", "tokenized_content": [2, 18632, 3, 6600, 1958, 7307, 17135, 1922, 3921, 1956, 18632, 19, 12681, 1958, 10221, 4408, 1922, 2132, 1956, 7471, 2137, 3]}, "items": [{"id": "p_4492", "content": "bortezomib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18632, 3, 3]}]}
{"query": {"id": "q_4493", "content": "dexamethasone [SEP] for intravenous cyclophosphamide in combination with bortezomib/dexamethasone for remission induction in patients with newly diagnosed myelom", "tokenized_content": [2, 12681, 3, 1958, 7307, 17135, 1922, 3921, 1956, 18632, 19, 12681, 1958, 10221, 4408, 1922, 2132, 1956, 7471, 5377, 5707, 1947, 3]}, "items": [{"id": "p_4493", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4494", "content": "myeloma [SEP] hasone for remission induction in patients with newly diagnosed myeloma.", "tokenized_content": [2, 14471, 3, 2258, 2290, 1958, 10221, 4408, 1922, 2132, 1956, 7471, 5377, 14471, 18, 3]}, "items": [{"id": "p_4494", "content": "Multiple Myeloma [SEP] A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, ", "score": 1, "type": null, "tokenized_content": [2, 3137, 14471, 3, 43, 10248, 1927, 6665, 3582, 2094, 15888, 1922, 7172, 11837, 3372, 18, 2176, 1977, 4378, 2007, 11602, 6012, 17909, 3701, 6026, 16, 3]}]}
{"query": {"id": "q_4495", "content": "cyclophosphamide [SEP] linical trial was initiated to evaluate the recommended dose of cyclophosphamide in combination with bortezomib and dexamethasone as induction t", "tokenized_content": [2, 17135, 3, 8128, 2046, 3046, 1982, 7796, 1942, 4323, 1920, 6198, 3253, 1927, 17135, 1922, 3921, 1956, 18632, 1930, 12681, 1966, 4408, 62, 3]}, "items": [{"id": "p_4495", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4496", "content": "bortezomib [SEP] te the recommended dose of cyclophosphamide in combination with bortezomib and dexamethasone as induction treatment before stem cell trans", "tokenized_content": [2, 18632, 3, 3602, 1920, 6198, 3253, 1927, 17135, 1922, 3921, 1956, 18632, 1930, 12681, 1966, 4408, 2311, 3119, 4402, 2024, 2127, 3]}, "items": [{"id": "p_4496", "content": "bortezomib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18632, 3, 3]}]}
{"query": {"id": "q_4497", "content": "dexamethasone [SEP] ded dose of cyclophosphamide in combination with bortezomib and dexamethasone as induction treatment before stem cell transplantation for you", "tokenized_content": [2, 12681, 3, 11481, 3253, 1927, 17135, 1922, 3921, 1956, 18632, 1930, 12681, 1966, 4408, 2311, 3119, 4402, 2024, 6530, 1958, 6253, 3]}, "items": [{"id": "p_4497", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4498", "content": "multiple myeloma [SEP]  cell transplantation for younger patients with newly diagnosed multiple myeloma (MM). Thirty patients were treated with three 21-day cycles of ", "tokenized_content": [2, 3137, 14471, 3, 2024, 6530, 1958, 7237, 2132, 1956, 7471, 5377, 3137, 14471, 12, 2489, 13, 18, 9942, 2132, 1985, 2868, 1956, 2559, 2900, 17, 3007, 6355, 1927, 3]}, "items": [{"id": "p_4498", "content": "Multiple Myeloma [SEP] A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, ", "score": 1, "type": null, "tokenized_content": [2, 3137, 14471, 3, 43, 10248, 1927, 6665, 3582, 2094, 15888, 1922, 7172, 11837, 3372, 18, 2176, 1977, 4378, 2007, 11602, 6012, 17909, 3701, 6026, 16, 3]}]}
{"query": {"id": "q_4499", "content": "MM [SEP] ion for younger patients with newly diagnosed multiple myeloma (MM). Thirty patients were treated with three 21-day cycles of bort", "tokenized_content": [2, 2489, 3, 4755, 1958, 7237, 2132, 1956, 7471, 5377, 3137, 14471, 12, 2489, 13, 18, 9942, 2132, 1985, 2868, 1956, 2559, 2900, 17, 3007, 6355, 1927, 7570, 1031, 3]}, "items": [{"id": "p_4499", "content": "Multiple Myeloma [SEP] A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, ", "score": 1, "type": null, "tokenized_content": [2, 3137, 14471, 3, 43, 10248, 1927, 6665, 3582, 2094, 15888, 1922, 7172, 11837, 3372, 18, 2176, 1977, 4378, 2007, 11602, 6012, 17909, 3701, 6026, 16, 3]}]}
{"query": {"id": "q_4500", "content": "gastrointestinal toxicities [SEP] isease. The most frequent adverse events were hematological and gastrointestinal toxicities as well as neuropathy. The results suggest that bortezomib in c", "tokenized_content": [2, 8375, 15251, 3, 1977, 18013, 1021, 18, 1920, 2501, 6439, 5246, 3916, 1985, 17339, 1930, 8375, 15251, 1966, 2486, 1966, 13177, 18, 1920, 2274, 3220, 1988, 18632, 1922, 45, 3]}, "items": [{"id": "p_4500", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_4501", "content": "neuropathy [SEP] s were hematological and gastrointestinal toxicities as well as neuropathy. The results suggest that bortezomib in combination with cyclop", "tokenized_content": [2, 13177, 3, 61, 1985, 17339, 1930, 8375, 15251, 1966, 2486, 1966, 13177, 18, 1920, 2274, 3220, 1988, 18632, 1922, 3921, 1956, 20585, 3]}, "items": [{"id": "p_4501", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4502", "content": "telmisartan [SEP] of the efficacy and tolerability of a fixed-dose combination of telmisartan and amlodipine versus amlodipine monotherapy in Indian adults w", "tokenized_content": [2, 5202, 7395, 5735, 7446, 1928, 3, 1927, 1920, 4348, 1930, 17934, 1927, 43, 4779, 17, 3253, 3921, 1927, 5202, 7395, 5735, 7446, 1928, 1930, 9508, 26584, 4072, 9508, 26584, 13767, 3]}, "items": [{"id": "p_4502", "content": "telmisartan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5202, 7395, 5735, 7446, 1928, 3, 3]}]}
{"query": {"id": "q_4503", "content": "amlodipine [SEP] and tolerability of a fixed-dose combination of telmisartan and amlodipine versus amlodipine monotherapy in Indian adults with stage II hy", "tokenized_content": [2, 9508, 26584, 3, 1930, 17934, 1927, 43, 4779, 17, 3253, 3921, 1927, 5202, 7395, 5735, 7446, 1928, 1930, 9508, 26584, 4072, 9508, 26584, 13767, 1922, 10733, 4440, 1956, 3587, 2890, 3]}, "items": [{"id": "p_4503", "content": "Amlodipine [SEP] A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.\n   ", "score": 1, "type": null, "tokenized_content": [2, 9508, 26584, 3, 43, 2815, 17, 8290, 11842, 18425, 5802, 5016, 4999, 14580, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 1930, 5579, 18, 3]}]}
{"query": {"id": "q_4504", "content": "hypertension [SEP] ne versus amlodipine monotherapy in Indian adults with stage II hypertension.", "tokenized_content": [2, 5579, 3, 2069, 4072, 9508, 26584, 13767, 1922, 10733, 4440, 1956, 3587, 2890, 5579, 18, 3]}, "items": [{"id": "p_4504", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4505", "content": "telmisartan [SEP] icacy and tolerability of a new fixed-dose combination (FDC) of telmisartan 40 mg + amlodipine 5 mg (T+A) compared with amlodipine 5-mg mon", "tokenized_content": [2, 5202, 7395, 5735, 7446, 1928, 3, 14784, 13796, 1930, 17934, 1927, 43, 2814, 4779, 17, 3253, 3921, 12, 8350, 1030, 13, 1927, 5202, 7395, 5735, 7446, 1928, 3040, 2786, 15, 3]}, "items": [{"id": "p_4505", "content": "telmisartan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5202, 7395, 5735, 7446, 1928, 3, 3]}]}
{"query": {"id": "q_4506", "content": "amlodipine [SEP] ty of a new fixed-dose combination (FDC) of telmisartan 40 mg + amlodipine 5 mg (T+A) compared with amlodipine 5-mg monotherapy (A) in adu", "tokenized_content": [2, 9508, 26584, 3, 6227, 1927, 43, 2814, 4779, 17, 3253, 3921, 12, 8350, 1030, 13, 1927, 5202, 7395, 5735, 7446, 1928, 3040, 2786, 15, 9508, 26584, 25, 2786, 12, 62, 3]}, "items": [{"id": "p_4506", "content": "Amlodipine [SEP] A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.\n   ", "score": 1, "type": null, "tokenized_content": [2, 9508, 26584, 3, 43, 2815, 17, 8290, 11842, 18425, 5802, 5016, 4999, 14580, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 1930, 5579, 18, 3]}]}
{"query": {"id": "q_4507", "content": "hypertension [SEP] ine 5-mg monotherapy (A) in adult Indian patients with stage II hypertension. METHODS: This comparative, Phase III, 12-week, multicenter, pr", "tokenized_content": [2, 5579, 3, 11116, 25, 17, 2786, 13767, 12, 43, 13, 1922, 4160, 10733, 2132, 1956, 3587, 2890, 5579, 18, 2860, 30, 2052, 8255, 16, 3193, 4337, 16, 2369, 17, 2982, 3]}, "items": [{"id": "p_4507", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4508", "content": "edema [SEP] ent groups (T+A, 16.0% [17/106]; A, 15.4% [16/104]). Peripheral edema was reported in 8.5% patients (9/106) in the T+A group compared", "tokenized_content": [2, 10144, 3, 8496, 2671, 12, 62, 15, 43, 16, 2641, 18, 20, 9, 37, 2752, 19, 7758, 39, 31, 43, 16, 2461, 18, 24, 9, 37, 2641, 19, 8824, 39, 3]}, "items": [{"id": "p_4508", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_4509", "content": "cough [SEP]  the T+A group compared with 13.5% (14/104) in the A group, and cough was reported in 3.8% patients (4/106) in the T+A group and 1.0%", "tokenized_content": [2, 13588, 3, 1920, 62, 15, 43, 2210, 2452, 1956, 2590, 18, 25, 9, 12, 2607, 19, 8824, 13, 1922, 1920, 43, 2210, 16, 1930, 13588, 1982, 2568, 1922, 23, 18, 3]}, "items": [{"id": "p_4509", "content": "Cough [SEP] A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective", "score": 1, "type": null, "tokenized_content": [2, 13588, 3, 43, 12446, 16, 18219, 7272, 2887, 12138, 1927, 4433, 2037, 1920, 9193, 2596, 43, 6426, 8047, 25632, 3519, 1937, 16, 16757, 2007, 14728, 18, 2176, 1977, 43, 6337, 3]}]}
{"query": {"id": "q_4510", "content": "headache [SEP] ences did not reach statistical significance. The incidences of headache, dizziness, and diarrhea were similar between the 2 groups. CON", "tokenized_content": [2, 12187, 3, 3350, 1918, 2811, 2084, 4393, 3850, 4550, 18, 1920, 20738, 1927, 12187, 16, 24009, 16, 1930, 11904, 1985, 2551, 2192, 1920, 22, 2671, 18, 1962, 3]}, "items": [{"id": "p_4510", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_4511", "content": "dizziness [SEP] not reach statistical significance. The incidences of headache, dizziness, and diarrhea were similar between the 2 groups. CONCLUSIONS: A", "tokenized_content": [2, 24009, 3, 2084, 4393, 3850, 4550, 18, 1920, 20738, 1927, 12187, 16, 24009, 16, 1930, 11904, 1985, 2551, 2192, 1920, 22, 2671, 18, 4355, 30, 43, 3]}, "items": [{"id": "p_4511", "content": "Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24009, 3, 1925, 26385, 2870, 2576, 2154, 2278, 3333, 1942, 43, 7534, 1927, 5067, 2054, 29292, 16, 6269, 1927, 1920, 3515, 16, 2014, 3696, 10611, 1919, 2971, 18, 3]}]}
{"query": {"id": "q_4512", "content": "diarrhea [SEP] stical significance. The incidences of headache, dizziness, and diarrhea were similar between the 2 groups. CONCLUSIONS: Among these Ind", "tokenized_content": [2, 11904, 3, 14243, 1923, 4550, 18, 1920, 20738, 1927, 12187, 16, 24009, 16, 1930, 11904, 1985, 2551, 2192, 1920, 22, 2671, 18, 4355, 30, 2706, 2144, 2063, 3]}, "items": [{"id": "p_4512", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_4513", "content": "Cutaneous leucocytoclastic vasculitis [SEP] Cutaneous leucocytoclastic vasculitis associated with oxacillin.", "tokenized_content": [2, 11276, 9906, 3107, 5406, 4054, 21548, 3, 11276, 9906, 3107, 5406, 4054, 21548, 2458, 1956, 28905, 10401, 7782, 18, 3]}, "items": [{"id": "p_4513", "content": "Vasculitis, Leukocytoclastic, Cutaneous [SEP] Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or othe", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 5104, 3107, 5406, 4054, 16, 11276, 3, 4770, 4378, 2007, 43, 10205, 12013, 4741, 2458, 1956, 3395, 1942, 1925, 4730, 2427, 1966, 43, 2838, 16, 7465, 5899, 16, 2014, 7608, 4116, 3]}]}
{"query": {"id": "q_4514", "content": "oxacillin [SEP] Cutaneous leucocytoclastic vasculitis associated with oxacillin.", "tokenized_content": [2, 28905, 10401, 7782, 3, 11276, 9906, 3107, 5406, 4054, 21548, 2458, 1956, 28905, 10401, 7782, 18, 3]}, "items": [{"id": "p_4514", "content": "Oxacillin [SEP] An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28905, 10401, 7782, 3, 1925, 7267, 2551, 1942, 19298, 6012, 11414, 10401, 7782, 2251, 1922, 4910, 11282, 16254, 5024, 18, 3]}]}
{"query": {"id": "q_4515", "content": "oxacillin [SEP] A 67-year-old man who was treated with oxacillin for one week because of Staphylococcus aureus bacteremia, devel", "tokenized_content": [2, 28905, 10401, 7782, 3, 43, 4838, 17, 2476, 17, 4156, 2323, 2746, 1982, 2868, 1956, 28905, 10401, 7782, 1958, 2340, 2982, 2882, 1927, 13452, 8849, 21168, 16, 4251, 1938, 3]}, "items": [{"id": "p_4515", "content": "Oxacillin [SEP] An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28905, 10401, 7782, 3, 1925, 7267, 2551, 1942, 19298, 6012, 11414, 10401, 7782, 2251, 1922, 4910, 11282, 16254, 5024, 18, 3]}]}
{"query": {"id": "q_4516", "content": "Staphylococcus aureus bacteremia [SEP] -old man who was treated with oxacillin for one week because of Staphylococcus aureus bacteremia, developed renal failure and diffuse, symmetric, palpable purpu", "tokenized_content": [2, 13452, 8849, 21168, 3, 17, 4156, 2323, 2746, 1982, 2868, 1956, 28905, 10401, 7782, 1958, 2340, 2982, 2882, 1927, 13452, 8849, 21168, 16, 3530, 4604, 4574, 1930, 9435, 16, 14416, 3]}, "items": [{"id": "p_4516", "content": "Staphylococcal Infections [SEP] Infections with bacteria of the genus STAPHYLOCOCCUS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27721, 5024, 3, 5024, 1956, 4802, 1927, 1920, 9487, 13452, 18, 3]}]}
{"query": {"id": "q_4517", "content": "bacteremia [SEP] ed with oxacillin for one week because of Staphylococcus aureus bacteremia, developed renal failure and diffuse, symmetric, palpable purpu", "tokenized_content": [2, 21168, 3, 3347, 1956, 28905, 10401, 7782, 1958, 2340, 2982, 2882, 1927, 13452, 8849, 21168, 16, 3530, 4604, 4574, 1930, 9435, 16, 14416, 16, 24845, 25945, 1032, 3]}, "items": [{"id": "p_4517", "content": "Bacteremia [SEP] The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestati", "score": 1, "type": null, "tokenized_content": [2, 21168, 3, 1920, 2990, 1927, 8978, 4802, 7396, 1922, 1920, 2877, 18, 9087, 16, 7368, 11560, 1036, 16, 17397, 16, 1930, 12762, 2085, 9707, 2032, 3059, 3939, 7943, 1968, 3]}]}
{"query": {"id": "q_4518", "content": "renal failure [SEP] one week because of Staphylococcus aureus bacteremia, developed renal failure and diffuse, symmetric, palpable purpuric lesions on his feet. ", "tokenized_content": [2, 4604, 4574, 3, 2340, 2982, 2882, 1927, 13452, 8849, 21168, 16, 3530, 4604, 4574, 1930, 9435, 16, 14416, 16, 24845, 25945, 15861, 4518, 1990, 4167, 18071, 18, 3]}, "items": [{"id": "p_4518", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4519", "content": "purpuric lesions [SEP] remia, developed renal failure and diffuse, symmetric, palpable purpuric lesions on his feet. Necrotic blisters were noted on his fingers. Skin ", "tokenized_content": [2, 25945, 15861, 4518, 3, 2500, 2126, 16, 3530, 4604, 4574, 1930, 9435, 16, 14416, 16, 24845, 25945, 15861, 4518, 1990, 4167, 18071, 18, 14275, 2266, 22111, 1985, 5040, 1990, 4167, 3]}, "items": [{"id": "p_4519", "content": "Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 3, 25945, 2951, 2014, 8084, 2471, 2312, 2863, 18778, 1943, 16, 7278, 7816, 2596, 1920, 14512, 16, 4189, 2007, 10489, 2460, 1920, 3878, 18, 2469, 1920, 5998, 3]}]}
{"query": {"id": "q_4520", "content": "Necrotic [SEP]  and diffuse, symmetric, palpable purpuric lesions on his feet. Necrotic blisters were noted on his fingers. Skin biopsies showed findin", "tokenized_content": [2, 14275, 3, 1930, 9435, 16, 14416, 16, 24845, 25945, 15861, 4518, 1990, 4167, 18071, 18, 14275, 2266, 22111, 1985, 5040, 1990, 4167, 18233, 18, 4407, 9782, 2594, 5387, 1921, 3]}, "items": [{"id": "p_4520", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_4521", "content": "blisters [SEP] use, symmetric, palpable purpuric lesions on his feet. Necrotic blisters were noted on his fingers. Skin biopsies showed findings diagno", "tokenized_content": [2, 2266, 22111, 3, 2485, 16, 14416, 16, 24845, 25945, 15861, 4518, 1990, 4167, 18071, 18, 14275, 2266, 22111, 1985, 5040, 1990, 4167, 18233, 18, 4407, 9782, 2594, 3056, 2822, 1037, 3]}, "items": [{"id": "p_4521", "content": "Blister [SEP] Visible accumulations of fluid within or beneath the epidermis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2266, 7263, 3, 7816, 4858, 1036, 1927, 5466, 2651, 2014, 22419, 1920, 14512, 18, 3]}]}
{"query": {"id": "q_4522", "content": "leucocytoclastic vasculitis [SEP] ted on his fingers. Skin biopsies showed findings diagnostic of leucocytoclastic vasculitis. Oxacillin was discontinued and patient was treated with cortic", "tokenized_content": [2, 9906, 3107, 5406, 4054, 21548, 3, 26080, 1990, 4167, 18233, 18, 4407, 9782, 2594, 3056, 4785, 1927, 9906, 3107, 5406, 4054, 21548, 18, 28905, 10401, 7782, 1982, 16087, 1930, 2774, 3]}, "items": [{"id": "p_4522", "content": "Vasculitis, Leukocytoclastic, Cutaneous [SEP] Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or othe", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 5104, 3107, 5406, 4054, 16, 11276, 3, 4770, 4378, 2007, 43, 10205, 12013, 4741, 2458, 1956, 3395, 1942, 1925, 4730, 2427, 1966, 43, 2838, 16, 7465, 5899, 16, 2014, 7608, 4116, 3]}]}
{"query": {"id": "q_4523", "content": "Oxacillin [SEP] sies showed findings diagnostic of leucocytoclastic vasculitis. Oxacillin was discontinued and patient was treated with corticosteroids. ", "tokenized_content": [2, 28905, 10401, 7782, 3, 17189, 1036, 2594, 3056, 4785, 1927, 9906, 3107, 5406, 4054, 21548, 18, 28905, 10401, 7782, 1982, 16087, 1930, 2774, 1982, 2868, 1956, 14610, 18, 3]}, "items": [{"id": "p_4523", "content": "Oxacillin [SEP] An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28905, 10401, 7782, 3, 1925, 7267, 2551, 1942, 19298, 6012, 11414, 10401, 7782, 2251, 1922, 4910, 11282, 16254, 5024, 18, 3]}]}
{"query": {"id": "q_4524", "content": "corticosteroids [SEP] ulitis. Oxacillin was discontinued and patient was treated with corticosteroids. The rash disappeared after three weeks and renal function retu", "tokenized_content": [2, 14610, 3, 3570, 3678, 18, 28905, 10401, 7782, 1982, 16087, 1930, 2774, 1982, 2868, 1956, 14610, 18, 1920, 18469, 15588, 2256, 2559, 3625, 1930, 4604, 2347, 3172, 1032, 3]}, "items": [{"id": "p_4524", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_4525", "content": "rash [SEP]  discontinued and patient was treated with corticosteroids. The rash disappeared after three weeks and renal function returned to no", "tokenized_content": [2, 18469, 3, 16087, 1930, 2774, 1982, 2868, 1956, 14610, 18, 1920, 18469, 15588, 2256, 2559, 3625, 1930, 4604, 2347, 10418, 1942, 2239, 3]}, "items": [{"id": "p_4525", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_4526", "content": "Leucocytoclastic vasculitis [SEP] peared after three weeks and renal function returned to normal. Leucocytoclastic vasculitis presents as palpable purpura of the lower extremities often acc", "tokenized_content": [2, 9906, 3107, 5406, 4054, 21548, 3, 8893, 1919, 2256, 2559, 3625, 1930, 4604, 2347, 10418, 1942, 2791, 18, 9906, 3107, 5406, 4054, 21548, 8178, 1966, 24845, 25945, 9280, 1927, 1920, 3]}, "items": [{"id": "p_4526", "content": "Vasculitis, Leukocytoclastic, Cutaneous [SEP] Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or othe", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 5104, 3107, 5406, 4054, 16, 11276, 3, 4770, 4378, 2007, 43, 10205, 12013, 4741, 2458, 1956, 3395, 1942, 1925, 4730, 2427, 1966, 43, 2838, 16, 7465, 5899, 16, 2014, 7608, 4116, 3]}]}
{"query": {"id": "q_4527", "content": "purpura [SEP] ned to normal. Leucocytoclastic vasculitis presents as palpable purpura of the lower extremities often accompanied by abdominal pain, a", "tokenized_content": [2, 25945, 9280, 3, 2069, 1007, 1942, 2791, 18, 9906, 3107, 5406, 4054, 21548, 8178, 1966, 24845, 25945, 9280, 1927, 1920, 2826, 18884, 3868, 7936, 2007, 6900, 3594, 16, 43, 3]}, "items": [{"id": "p_4527", "content": "Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 3, 25945, 2951, 2014, 8084, 2471, 2312, 2863, 18778, 1943, 16, 7278, 7816, 2596, 1920, 14512, 16, 4189, 2007, 10489, 2460, 1920, 3878, 18, 2469, 1920, 5998, 3]}]}
{"query": {"id": "q_4528", "content": "abdominal pain [SEP]  palpable purpura of the lower extremities often accompanied by abdominal pain, arthralgia, and renal involvement. Etiologic factors or associ", "tokenized_content": [2, 6900, 3594, 3, 24845, 25945, 9280, 1927, 1920, 2826, 18884, 3868, 7936, 2007, 6900, 3594, 16, 9273, 7317, 11966, 16, 1930, 4604, 5668, 18, 27633, 2790, 2014, 2293, 3]}, "items": [{"id": "p_4528", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_4529", "content": "arthralgia [SEP] a of the lower extremities often accompanied by abdominal pain, arthralgia, and renal involvement. Etiologic factors or associated disorde", "tokenized_content": [2, 9273, 7317, 11966, 3, 43, 1927, 1920, 2826, 18884, 3868, 7936, 2007, 6900, 3594, 16, 9273, 7317, 11966, 16, 1930, 4604, 5668, 18, 27633, 2790, 2014, 2458, 2054, 2538, 1021, 3]}, "items": [{"id": "p_4529", "content": "Arthralgia [SEP] Pain in the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 7317, 11966, 3, 3594, 1922, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_4530", "content": "renal involvement [SEP] xtremities often accompanied by abdominal pain, arthralgia, and renal involvement. Etiologic factors or associated disorders include infections, ", "tokenized_content": [2, 4604, 5668, 3, 23068, 23505, 2569, 3868, 7936, 2007, 6900, 3594, 16, 9273, 7317, 11966, 16, 1930, 4604, 5668, 18, 27633, 2790, 2014, 2458, 4414, 3951, 5024, 16, 3]}, "items": [{"id": "p_4530", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4531", "content": "infections [SEP]  involvement. Etiologic factors or associated disorders include infections, medications, collagen vascular disease and neoplasia. However,", "tokenized_content": [2, 5024, 3, 5668, 18, 27633, 2790, 2014, 2458, 4414, 3951, 5024, 16, 7719, 16, 5621, 4541, 2573, 1930, 17773, 18, 2406, 16, 3]}, "items": [{"id": "p_4531", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_4532", "content": "collagen vascular disease [SEP] actors or associated disorders include infections, medications, collagen vascular disease and neoplasia. However, in half of the cases no etiologic facto", "tokenized_content": [2, 5621, 4541, 2573, 3, 21960, 2014, 2458, 4414, 3951, 5024, 16, 7719, 16, 5621, 4541, 2573, 1930, 17773, 18, 2406, 16, 1922, 4768, 1927, 1920, 2919, 2239, 27633, 2371, 1037, 3]}, "items": [{"id": "p_4532", "content": "Collagen Diseases [SEP] Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus,", "score": 1, "type": null, "tokenized_content": [2, 5621, 3902, 3, 18011, 16, 43, 8538, 2210, 1927, 3939, 1930, 3724, 3902, 16, 2710, 13053, 8884, 16, 5510, 13711, 22045, 16, 3]}]}
{"query": {"id": "q_4533", "content": "neoplasia [SEP]  include infections, medications, collagen vascular disease and neoplasia. However, in half of the cases no etiologic factor is identifie", "tokenized_content": [2, 17773, 3, 3951, 5024, 16, 7719, 16, 5621, 4541, 2573, 1930, 17773, 18, 2406, 16, 1922, 4768, 1927, 1920, 2919, 2239, 27633, 2991, 1977, 2473, 2621, 3]}, "items": [{"id": "p_4533", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4534", "content": "corticosteroid [SEP] ulitis. Oxacillin was discontinued and patient was treated with corticosteroids. The rash disappeared after three weeks and renal function ret", "tokenized_content": [2, 17980, 3, 3570, 3678, 18, 28905, 10401, 7782, 1982, 16087, 1930, 2774, 1982, 2868, 1956, 14610, 18, 1920, 18469, 15588, 2256, 2559, 3625, 1930, 4604, 2347, 3172, 3]}, "items": [{"id": "p_4534", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_4535", "content": "Naloxazone [SEP] Naloxazone pretreatment modifies cardiorespiratory, temperature, and behav", "tokenized_content": [2, 13120, 2325, 14316, 3, 13120, 2325, 14316, 9111, 25436, 28158, 16, 3449, 16, 1930, 22406, 3]}, "items": [{"id": "p_4535", "content": "naloxazone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13120, 2325, 14316, 3, 3]}]}
{"query": {"id": "q_4536", "content": "morphine [SEP] ifies cardiorespiratory, temperature, and behavioral effects of morphine.", "tokenized_content": [2, 11553, 3, 29784, 1918, 28158, 16, 3449, 16, 1930, 5343, 2564, 1927, 11553, 18, 3]}, "items": [{"id": "p_4536", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4537", "content": "morphine [SEP] Behavioral and cardiorespiratory responses to a lethal dose of morphine were evaluated in rats pretreated with saline or naloxazone, an", "tokenized_content": [2, 11553, 3, 5343, 1930, 28158, 3387, 1942, 43, 10470, 3253, 1927, 11553, 1985, 3747, 1922, 3615, 12152, 1956, 5977, 2014, 13120, 2325, 14316, 16, 1925, 3]}, "items": [{"id": "p_4537", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4538", "content": "naloxazone [SEP] se of morphine were evaluated in rats pretreated with saline or naloxazone, an antagonist of high-affinity mu 1 opioid receptors. Pretreat", "tokenized_content": [2, 13120, 2325, 14316, 3, 2058, 1927, 11553, 1985, 3747, 1922, 3615, 12152, 1956, 5977, 2014, 13120, 2325, 14316, 16, 1925, 8151, 1927, 2149, 17, 5173, 8975, 21, 9384, 4086, 18, 3]}, "items": [{"id": "p_4538", "content": "naloxazone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13120, 2325, 14316, 3, 3]}]}
{"query": {"id": "q_4539", "content": "analgesia [SEP] rs. Pretreatment with naloxazone significantly blocked morphine analgesia, catalepsy and hypothermia at a dose which completely eliminate", "tokenized_content": [2, 14695, 3, 4366, 18, 9111, 1956, 13120, 2325, 14316, 2567, 6923, 11553, 14695, 16, 4233, 9431, 1012, 1930, 18750, 2019, 43, 3253, 2154, 5796, 11134, 3]}, "items": [{"id": "p_4539", "content": "Pain Insensitivity, Congenital [SEP] A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent cor", "score": 1, "type": null, "tokenized_content": [2, 3594, 30055, 16, 9901, 3, 43, 4741, 4378, 2007, 2063, 11307, 2055, 1942, 3594, 4281, 1920, 3682, 1942, 7279, 24218, 2037, 2447, 17, 24218, 5458, 18, 7685, 2233, 3]}]}
{"query": {"id": "q_4540", "content": "catalepsy [SEP] tment with naloxazone significantly blocked morphine analgesia, catalepsy and hypothermia at a dose which completely eliminated high-affi", "tokenized_content": [2, 4233, 9431, 1012, 3, 22377, 4905, 1956, 13120, 2325, 14316, 2567, 6923, 11553, 14695, 16, 4233, 9431, 1012, 1930, 18750, 2019, 43, 3253, 2154, 5796, 11412, 2149, 17, 2633, 1033, 3]}, "items": [{"id": "p_4540", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4541", "content": "hypothermia [SEP] oxazone significantly blocked morphine analgesia, catalepsy and hypothermia at a dose which completely eliminated high-affinity binding in ", "tokenized_content": [2, 18750, 3, 28905, 13642, 2912, 2567, 6923, 11553, 14695, 16, 4233, 9431, 1012, 1930, 18750, 2019, 43, 3253, 2154, 5796, 11412, 2149, 17, 5173, 2743, 1922, 3]}, "items": [{"id": "p_4541", "content": "Hypothermia [SEP] Lower than normal body temperature, especially in warm-blooded animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18750, 3, 2826, 2254, 2791, 3362, 3449, 16, 4369, 1922, 10142, 17, 2877, 1919, 3555, 18, 3]}]}
{"query": {"id": "q_4542", "content": "hypotension [SEP] eover, naloxazone significantly attenuated the morphine-induced hypotension and respiratory depression, whereas morphine-induced bradycardi", "tokenized_content": [2, 16453, 3, 21996, 2004, 16, 13120, 2325, 14316, 2567, 8060, 1920, 11553, 17, 2719, 16453, 1930, 5481, 4621, 16, 3417, 11553, 17, 2719, 20152, 15339, 7408, 3]}, "items": [{"id": "p_4542", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4543", "content": "respiratory depression [SEP] e significantly attenuated the morphine-induced hypotension and respiratory depression, whereas morphine-induced bradycardia was less affected. Result", "tokenized_content": [2, 5481, 4621, 3, 47, 2567, 8060, 1920, 11553, 17, 2719, 16453, 1930, 5481, 4621, 16, 3417, 11553, 17, 2719, 26192, 1982, 2941, 4218, 18, 3211, 3]}, "items": [{"id": "p_4543", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4544", "content": "bradycardia [SEP] ypotension and respiratory depression, whereas morphine-induced bradycardia was less affected. Results indicate that subpopulations of mu r", "tokenized_content": [2, 26192, 3, 21995, 7229, 3355, 2001, 1930, 5481, 4621, 16, 3417, 11553, 17, 2719, 26192, 1982, 2941, 4218, 18, 2274, 3579, 1988, 14349, 1927, 8975, 60, 3]}, "items": [{"id": "p_4544", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_4545", "content": "Dexrazoxane [SEP] Dexrazoxane protects against myelosuppression from the DNA cleavage-enhanci", "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 7473, 5524, 13642, 11414, 2912, 14576, 3316, 5707, 1951, 3481, 3124, 2037, 1920, 2678, 6404, 17, 3102, 2412, 1033, 3]}, "items": [{"id": "p_4545", "content": "Dexrazoxane [SEP] The (+)-enantiomorph of razoxane.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 1920, 12, 15, 13, 17, 14676, 10728, 1927, 30088, 18760, 18, 3]}]}
{"query": {"id": "q_4546", "content": "myelosuppression [SEP] Dexrazoxane protects against myelosuppression from the DNA cleavage-enhancing drugs etoposide and daunorubici", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 7473, 5524, 13642, 11414, 2912, 14576, 3316, 5707, 1951, 3481, 3124, 2037, 1920, 2678, 6404, 17, 9221, 4195, 18892, 1930, 3692, 1983, 1924, 2255, 2478, 3]}, "items": [{"id": "p_4546", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_4547", "content": "etoposide [SEP]  against myelosuppression from the DNA cleavage-enhancing drugs etoposide and daunorubicin but not doxorubicin.", "tokenized_content": [2, 18892, 3, 3316, 5707, 1951, 3481, 3124, 2037, 1920, 2678, 6404, 17, 9221, 4195, 18892, 1930, 3692, 1983, 11891, 2308, 2084, 12377, 18, 3]}, "items": [{"id": "p_4547", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_4548", "content": "daunorubicin [SEP] suppression from the DNA cleavage-enhancing drugs etoposide and daunorubicin but not doxorubicin.", "tokenized_content": [2, 3692, 1983, 11891, 3, 6412, 2037, 1920, 2678, 6404, 17, 9221, 4195, 18892, 1930, 3692, 1983, 11891, 2308, 2084, 12377, 18, 3]}, "items": [{"id": "p_4548", "content": "Daunorubicin [SEP] A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of L", "score": 1, "type": null, "tokenized_content": [2, 3692, 1983, 11891, 3, 43, 3345, 6161, 30021, 23029, 8028, 29128, 9969, 3937, 2037, 22874, 2737, 3005, 1914, 1957, 1930, 4991, 16, 2251, 1922, 2311, 1927, 54, 3]}]}
{"query": {"id": "q_4549", "content": "doxorubicin [SEP] DNA cleavage-enhancing drugs etoposide and daunorubicin but not doxorubicin.", "tokenized_content": [2, 12377, 3, 2678, 6404, 17, 9221, 4195, 18892, 1930, 3692, 1983, 11891, 2308, 2084, 12377, 18, 3]}, "items": [{"id": "p_4549", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4550", "content": "anthracyclines [SEP] PURPOSE: The anthracyclines daunorubicin and doxorubicin and the epipodophyllotoxin etoposi", "tokenized_content": [2, 30021, 1036, 3, 5120, 30, 1920, 30021, 1036, 3692, 1983, 11891, 1930, 12377, 1930, 1920, 13872, 7056, 22389, 25818, 11560, 11140, 18712, 27545, 3]}, "items": [{"id": "p_4550", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_4551", "content": "daunorubicin [SEP] PURPOSE: The anthracyclines daunorubicin and doxorubicin and the epipodophyllotoxin etoposide are potent", "tokenized_content": [2, 3692, 1983, 11891, 3, 5120, 30, 1920, 30021, 1036, 3692, 1983, 11891, 1930, 12377, 1930, 1920, 13872, 7056, 22389, 25818, 11560, 11140, 18892, 2032, 6828, 3]}, "items": [{"id": "p_4551", "content": "Daunorubicin [SEP] A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of L", "score": 1, "type": null, "tokenized_content": [2, 3692, 1983, 11891, 3, 43, 3345, 6161, 30021, 23029, 8028, 29128, 9969, 3937, 2037, 22874, 2737, 3005, 1914, 1957, 1930, 4991, 16, 2251, 1922, 2311, 1927, 54, 3]}]}
{"query": {"id": "q_4552", "content": "doxorubicin [SEP] PURPOSE: The anthracyclines daunorubicin and doxorubicin and the epipodophyllotoxin etoposide are potent DNA cleavage-en", "tokenized_content": [2, 12377, 3, 5120, 30, 1920, 30021, 1036, 3692, 1983, 11891, 1930, 12377, 1930, 1920, 13872, 7056, 22389, 25818, 11560, 11140, 18892, 2032, 6828, 2678, 6404, 17, 2066, 3]}, "items": [{"id": "p_4552", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4553", "content": "epipodophyllotoxin [SEP] URPOSE: The anthracyclines daunorubicin and doxorubicin and the epipodophyllotoxin etoposide are potent DNA cleavage-enhancing drugs that are wide", "tokenized_content": [2, 13872, 7056, 22389, 25818, 11560, 11140, 3, 3674, 4304, 30, 1920, 30021, 1036, 3692, 1983, 11891, 1930, 12377, 1930, 1920, 13872, 7056, 22389, 25818, 11560, 11140, 18892, 2032, 6828, 2678, 3]}, "items": [{"id": "p_4553", "content": "Podophyllotoxin [SEP] A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if take", "score": 1, "type": null, "tokenized_content": [2, 10181, 13384, 11140, 3, 43, 12975, 1928, 12, 12975, 2075, 13, 2435, 1922, 10181, 13384, 1921, 10441, 2037, 1920, 9398, 1927, 10181, 13384, 1989, 4793, 18, 2176, 1977, 43, 6828, 10716, 15501, 16, 6161, 2647, 6132, 3]}]}
{"query": {"id": "q_4554", "content": "etoposide [SEP] yclines daunorubicin and doxorubicin and the epipodophyllotoxin etoposide are potent DNA cleavage-enhancing drugs that are widely used in", "tokenized_content": [2, 18892, 3, 22386, 26037, 3692, 1983, 11891, 1930, 12377, 1930, 1920, 13872, 7056, 22389, 25818, 11560, 11140, 18892, 2032, 6828, 2678, 6404, 17, 9221, 4195, 1988, 2032, 5673, 2251, 1922, 3]}, "items": [{"id": "p_4554", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_4555", "content": "myelosuppression [SEP] ncing drugs that are widely used in clinical oncology; however, myelosuppression and cardiac toxicity limit their use. Dexrazoxane (ICRF-187) is", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 14188, 2029, 4195, 1988, 2032, 5673, 2251, 1922, 2535, 11605, 31, 2406, 16, 5707, 1951, 3481, 3124, 1930, 4435, 5532, 4411, 2310, 2485, 18, 7473, 3]}, "items": [{"id": "p_4555", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_4556", "content": "cardiac toxicity [SEP] widely used in clinical oncology; however, myelosuppression and cardiac toxicity limit their use. Dexrazoxane (ICRF-187) is recommended for prot", "tokenized_content": [2, 4435, 5532, 3, 5673, 2251, 1922, 2535, 11605, 31, 2406, 16, 5707, 1951, 3481, 3124, 1930, 4435, 5532, 4411, 2310, 2485, 18, 7473, 5524, 13642, 11414, 2912, 12, 19778, 1038, 3]}, "items": [{"id": "p_4556", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4557", "content": "Dexrazoxane [SEP] however, myelosuppression and cardiac toxicity limit their use. Dexrazoxane (ICRF-187) is recommended for protection against anthracycline-", "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 2406, 16, 5707, 1951, 3481, 3124, 1930, 4435, 5532, 4411, 2310, 2485, 18, 7473, 5524, 13642, 11414, 2912, 12, 19778, 1038, 17, 16819, 13, 3]}, "items": [{"id": "p_4557", "content": "Dexrazoxane [SEP] The (+)-enantiomorph of razoxane.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 1920, 12, 15, 13, 17, 14676, 10728, 1927, 30088, 18760, 18, 3]}]}
{"query": {"id": "q_4558", "content": "ICRF-187 [SEP] osuppression and cardiac toxicity limit their use. Dexrazoxane (ICRF-187) is recommended for protection against anthracycline-induced ca", "tokenized_content": [2, 19778, 1038, 17, 16819, 3, 3125, 3481, 3124, 1930, 4435, 5532, 4411, 2310, 2485, 18, 7473, 5524, 13642, 11414, 2912, 12, 19778, 1038, 17, 16819, 13, 1977, 6198, 1958, 6202, 3]}, "items": [{"id": "p_4558", "content": "Dexrazoxane [SEP] The (+)-enantiomorph of razoxane.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 1920, 12, 15, 13, 17, 14676, 10728, 1927, 30088, 18760, 18, 3]}]}
{"query": {"id": "q_4559", "content": "anthracycline [SEP] PURPOSE: The anthracyclines daunorubicin and doxorubicin and the epipodophyllotoxin etopos", "tokenized_content": [2, 30021, 3, 5120, 30, 1920, 30021, 1036, 3692, 1983, 11891, 1930, 12377, 1930, 1920, 13872, 7056, 22389, 25818, 11560, 11140, 18712, 1951, 3]}, "items": [{"id": "p_4559", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_4560", "content": "cardiotoxicity [SEP] 87) is recommended for protection against anthracycline-induced cardiotoxicity. EXPERIMENTAL DESIGN: Because of their widespread use, the hema", "tokenized_content": [2, 30490, 3, 5783, 13, 1977, 6198, 1958, 6202, 3316, 30021, 17, 2719, 30490, 18, 3599, 3036, 30, 2882, 1927, 2310, 9360, 2485, 16, 1920, 3243, 1019, 3]}, "items": [{"id": "p_4560", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4561", "content": "hematologic toxicity [SEP] city. EXPERIMENTAL DESIGN: Because of their widespread use, the hematologic toxicity following coadministration of dexrazoxane and these three struc", "tokenized_content": [2, 18251, 5532, 3, 8318, 18, 3599, 3036, 30, 2882, 1927, 2310, 9360, 2485, 16, 1920, 18251, 5532, 2894, 29818, 8547, 3934, 1927, 7473, 5524, 13642, 11414, 2912, 1930, 2144, 2559, 3]}, "items": [{"id": "p_4561", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_4562", "content": "dexrazoxane [SEP] ead use, the hematologic toxicity following coadministration of dexrazoxane and these three structurally different DNA cleavage enhancers w", "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 11377, 1007, 2485, 16, 1920, 18251, 5532, 2894, 29818, 8547, 3934, 1927, 7473, 5524, 13642, 11414, 2912, 1930, 2144, 2559, 12171, 2413, 2678, 6404, 3]}, "items": [{"id": "p_4562", "content": "Dexrazoxane [SEP] The (+)-enantiomorph of razoxane.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7473, 5524, 13642, 11414, 2912, 3, 1920, 12, 15, 13, 17, 14676, 10728, 1927, 30088, 18760, 18, 3]}]}
{"query": {"id": "q_4563", "content": "weight loss [SEP] LTS: Nontoxic doses of dexrazoxane reduced myelosuppression and weight loss from daunorubicin and etoposide in mice and antagonized their a", "tokenized_content": [2, 3388, 3257, 3, 3457, 1036, 30, 18037, 10605, 5312, 1927, 7473, 5524, 13642, 11414, 2912, 3028, 5707, 1951, 3481, 3124, 1930, 3388, 3257, 2037, 3692, 1983, 11891, 1930, 18892, 1922, 3]}, "items": [{"id": "p_4563", "content": "Weight Loss [SEP] Decrease in existing BODY WEIGHT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 3257, 3, 3714, 1922, 6124, 3362, 3388, 18, 3]}]}
{"query": {"id": "q_4564", "content": "cytotoxicity [SEP] neither reduced myelosuppression, weight loss, nor the in vitro cytotoxicity from doxorubicin. CONCLUSION: Although our findings support the", "tokenized_content": [2, 8470, 3, 7132, 3028, 5707, 1951, 3481, 3124, 16, 3388, 3257, 16, 3990, 1920, 1922, 3596, 8470, 2037, 12377, 18, 4180, 30, 2876, 2342, 3056, 3373, 1920, 3]}, "items": [{"id": "p_4564", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4565", "content": "metastases [SEP]  the use of dexrazoxane. Clinical trials in patients with brain metastases combining dexrazoxane and high doses of etoposide is ongoing wi", "tokenized_content": [2, 8174, 3, 1920, 2485, 1927, 7473, 5524, 13642, 11414, 2912, 18, 2535, 3848, 1922, 2132, 1956, 3068, 8174, 9138, 7473, 5524, 13642, 11414, 2912, 1930, 2149, 5312, 1927, 18892, 1977, 3]}, "items": [{"id": "p_4565", "content": "Neoplasm Metastasis [SEP] The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12132, 5967, 3, 1920, 3856, 1927, 43, 12132, 2037, 2340, 3090, 2014, 3131, 1927, 1920, 3362, 1942, 3741, 12597, 2037, 1920, 3065, 3200, 18, 3]}]}
{"query": {"id": "q_4566", "content": "aniracetam [SEP] Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents.", "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 2564, 1927, 1920, 4008, 3547, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 13, 4073, 5761, 4809, 1930, 4525, 1922, 12035, 3]}, "items": [{"id": "p_4566", "content": "aniracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_4567", "content": "Ro 13-5057 [SEP] Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents.", "tokenized_content": [2, 3039, 2590, 17, 25987, 1027, 3, 2564, 1927, 1920, 4008, 3547, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 13, 4073, 5761, 4809, 1930, 4525, 1922, 12035, 3]}, "items": [{"id": "p_4567", "content": "aniracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_4568", "content": "impaired learning [SEP] Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents.", "tokenized_content": [2, 5761, 4809, 3, 2564, 1927, 1920, 4008, 3547, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 13, 4073, 5761, 4809, 1930, 4525, 1922, 12035, 18, 3]}, "items": [{"id": "p_4568", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_4569", "content": "aniracetam [SEP] The effect of aniracetam (Ro 13-5057, 1-anisoyl-2-pyrrolidinone) was studied on various ", "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 1920, 2495, 1927, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 16, 21, 17, 11453, 10921, 17, 22, 17, 23878, 22267, 3]}, "items": [{"id": "p_4569", "content": "aniracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_4570", "content": "Ro 13-5057 [SEP] The effect of aniracetam (Ro 13-5057, 1-anisoyl-2-pyrrolidinone) was studied on various forms of exp", "tokenized_content": [2, 3039, 2590, 17, 25987, 1027, 3, 1920, 2495, 1927, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 16, 21, 17, 11453, 10921, 17, 22, 17, 23878, 22267, 3]}, "items": [{"id": "p_4570", "content": "aniracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_4571", "content": "1-anisoyl-2-pyrrolidinone [SEP] The effect of aniracetam (Ro 13-5057, 1-anisoyl-2-pyrrolidinone) was studied on various forms of experimentally impaired cognit", "tokenized_content": [2, 21, 17, 11453, 10921, 17, 22, 17, 23878, 22267, 2912, 3, 1920, 2495, 1927, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 16, 21, 17, 11453, 10921, 3]}, "items": [{"id": "p_4571", "content": "aniracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1925, 11979, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_4572", "content": "impaired cognitive functions [SEP] 2-pyrrolidinone) was studied on various forms of experimentally impaired cognitive functions (learning and memory) in rodents and produced the following eff", "tokenized_content": [2, 5761, 4328, 4088, 3, 22, 17, 23878, 22267, 2912, 13, 1982, 3942, 1990, 3425, 4952, 1927, 9568, 5761, 4328, 4088, 12, 4809, 1930, 4525, 13, 1922, 12035, 1930, 4152, 1920, 3]}, "items": [{"id": "p_4572", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_4573", "content": "hypercapnia [SEP] o learn a discrete escape response in rats exposed to sublethal hypercapnia immediately before the acquisition session; (2) partial (rats) ", "tokenized_content": [2, 28016, 10306, 3, 57, 12048, 43, 10484, 11781, 2644, 1922, 3615, 4616, 1942, 20764, 29382, 28016, 10306, 6183, 3119, 1920, 6165, 7355, 31, 12, 22, 13, 5740, 12, 3615, 13, 3]}, "items": [{"id": "p_4573", "content": "Hypercapnia [SEP] A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28016, 10306, 3, 43, 2535, 15570, 1927, 4552, 2760, 1922, 1920, 4351, 1927, 5056, 15422, 1922, 6624, 2877, 18, 3]}]}
{"query": {"id": "q_4574", "content": "scopolamine [SEP] ession; (2) partial (rats) or complete (mice) prevention of the scopolamine-induced short-term amnesia for a passive avoidance task; (3) co", "tokenized_content": [2, 25392, 10173, 25157, 3, 4023, 2001, 31, 12, 22, 13, 5740, 12, 3615, 13, 2014, 4080, 12, 2518, 13, 5455, 1927, 1920, 25392, 10173, 25157, 17, 2719, 3662, 17, 2576, 3]}, "items": [{"id": "p_4574", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4575", "content": "amnesia [SEP] omplete (mice) prevention of the scopolamine-induced short-term amnesia for a passive avoidance task; (3) complete protection against a", "tokenized_content": [2, 14701, 7156, 3, 21921, 28566, 12, 2518, 13, 5455, 1927, 1920, 25392, 10173, 25157, 17, 2719, 3662, 17, 2576, 14701, 7156, 1958, 43, 9832, 11700, 3909, 31, 12, 23, 13, 3]}, "items": [{"id": "p_4575", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_4576", "content": "chloramphenicol [SEP] eficit for a passive avoidance task induced in rats and mice by chloramphenicol or cycloheximide administered immediately after acquisition; (5", "tokenized_content": [2, 20125, 3, 8485, 19753, 1958, 43, 9832, 11700, 3909, 2719, 1922, 3615, 1930, 2518, 2007, 20125, 2014, 21279, 5254, 6183, 2256, 6165, 31, 12, 25, 3]}, "items": [{"id": "p_4576", "content": "Chloramphenicol [SEP] An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relativel", "score": 1, "type": null, "tokenized_content": [2, 20125, 3, 1925, 7267, 2561, 3937, 2037, 5054, 1927, 22874, 26803, 5089, 5148, 1021, 1922, 17073, 1027, 2308, 5195, 4152, 6830, 2169, 18, 2176, 2258, 43, 3338, 1024, 3]}]}
{"query": {"id": "q_4577", "content": "cycloheximide [SEP] e avoidance task induced in rats and mice by chloramphenicol or cycloheximide administered immediately after acquisition; (5) reversal, when ", "tokenized_content": [2, 21279, 3, 47, 11700, 3909, 2719, 1922, 3615, 1930, 2518, 2007, 20125, 2014, 21279, 5254, 6183, 2256, 6165, 31, 12, 25, 13, 12393, 16, 2469, 3]}, "items": [{"id": "p_4577", "content": "Cycloheximide [SEP] Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation duri", "score": 1, "type": null, "tokenized_content": [2, 21279, 3, 7267, 7311, 3937, 2037, 10666, 17, 7144, 4046, 1927, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 9971, 2335, 1033, 3]}]}
{"query": {"id": "q_4578", "content": "Piracetam [SEP] ctivity of aniracetam and its 'therapeutic window' are unknown. Piracetam, another pyrrolidinone derivative was used for comparison. It w", "tokenized_content": [2, 13774, 7681, 1976, 3, 3369, 10794, 1927, 1925, 11979, 1972, 3857, 1035, 1930, 2496, 11, 4272, 8161, 11, 2032, 5435, 18, 13774, 7681, 1976, 16, 3741, 23878, 22267, 2912, 10533, 3]}, "items": [{"id": "p_4578", "content": "Piracetam [SEP] A compound suggested to be both a nootropic and a neuroprotective agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13774, 7681, 1976, 3, 43, 3547, 3978, 1942, 1998, 2321, 43, 2239, 8405, 1930, 43, 14345, 5899, 18, 3]}]}
{"query": {"id": "q_4579", "content": "pyrrolidinone [SEP] The effect of aniracetam (Ro 13-5057, 1-anisoyl-2-pyrrolidinone) was studied on various forms of experimentally impaired cognit", "tokenized_content": [2, 23878, 22267, 2912, 3, 1920, 2495, 1927, 1925, 11979, 1972, 3857, 1035, 12, 3039, 2590, 17, 25987, 1027, 16, 21, 17, 11453, 10921, 17, 22, 17, 23878, 22267, 2912, 13, 3]}, "items": [{"id": "p_4579", "content": "Pyrrolidinones [SEP] A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermed", "score": 1, "type": null, "tokenized_content": [2, 23878, 22267, 11682, 3, 43, 2210, 1927, 4300, 1988, 2032, 8383, 1927, 18588, 17, 23878, 29514, 18, 43, 7210, 1927, 2052, 2210, 1977, 22, 17, 18588, 23878, 5802, 16, 2154, 1977, 1925, 15177, 1919, 3]}]}
{"query": {"id": "q_4580", "content": "Nicotine [SEP] Nicotine potentiation of morphine-induced catalepsy in mice.", "tokenized_content": [2, 9303, 3, 9303, 16020, 1927, 11553, 17, 2719, 4233, 9431, 1012, 1922, 2518, 18, 3]}, "items": [{"id": "p_4580", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_4581", "content": "morphine [SEP] Nicotine potentiation of morphine-induced catalepsy in mice.", "tokenized_content": [2, 11553, 3, 9303, 16020, 1927, 11553, 17, 2719, 4233, 9431, 1012, 1922, 2518, 18, 3]}, "items": [{"id": "p_4581", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4582", "content": "catalepsy [SEP] Nicotine potentiation of morphine-induced catalepsy in mice.", "tokenized_content": [2, 4233, 9431, 1012, 3, 9303, 16020, 1927, 11553, 17, 2719, 4233, 9431, 1012, 1922, 2518, 18, 3]}, "items": [{"id": "p_4582", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4583", "content": "nicotine [SEP] In the present study, effects of nicotine on catalepsy induced by morphine in mice have been investigated", "tokenized_content": [2, 9303, 3, 1922, 1920, 2481, 2161, 16, 2564, 1927, 9303, 1990, 4233, 9431, 1012, 2719, 2007, 11553, 1922, 2518, 2162, 2252, 3845, 3]}, "items": [{"id": "p_4583", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_4584", "content": "catalepsy [SEP] In the present study, effects of nicotine on catalepsy induced by morphine in mice have been investigated. Morphine bu", "tokenized_content": [2, 4233, 9431, 1012, 3, 1922, 1920, 2481, 2161, 16, 2564, 1927, 9303, 1990, 4233, 9431, 1012, 2719, 2007, 11553, 1922, 2518, 2162, 2252, 3845, 18, 11553, 3168, 3]}, "items": [{"id": "p_4584", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4585", "content": "morphine [SEP]  the present study, effects of nicotine on catalepsy induced by morphine in mice have been investigated. Morphine but not nicotine induc", "tokenized_content": [2, 11553, 3, 1920, 2481, 2161, 16, 2564, 1927, 9303, 1990, 4233, 9431, 1012, 2719, 2007, 11553, 1922, 2518, 2162, 2252, 3845, 18, 11553, 2308, 2084, 9303, 4320, 3]}, "items": [{"id": "p_4585", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4586", "content": "Morphine [SEP] n catalepsy induced by morphine in mice have been investigated. Morphine but not nicotine induced a dose-dependent catalepsy. The respon", "tokenized_content": [2, 11553, 3, 56, 4233, 9431, 1012, 2719, 2007, 11553, 1922, 2518, 2162, 2252, 3845, 18, 11553, 2308, 2084, 9303, 2719, 43, 3253, 17, 3100, 4233, 9431, 1012, 18, 1920, 2163, 3]}, "items": [{"id": "p_4586", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4587", "content": "atropine [SEP]  was potentiated by nicotine. Intraperitoneal administration of atropine, naloxone, mecamylamine, and hexamethonium to mice reduced cata", "tokenized_content": [2, 24031, 3, 1982, 20419, 2007, 9303, 18, 13006, 4183, 1927, 24031, 16, 21926, 16, 10685, 27302, 3812, 16, 1930, 7142, 10758, 15414, 1942, 2518, 3028, 3115, 1019, 3]}, "items": [{"id": "p_4587", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_4588", "content": "naloxone [SEP] tiated by nicotine. Intraperitoneal administration of atropine, naloxone, mecamylamine, and hexamethonium to mice reduced catalepsy indu", "tokenized_content": [2, 21926, 3, 22093, 2013, 2007, 9303, 18, 13006, 4183, 1927, 24031, 16, 21926, 16, 10685, 27302, 3812, 16, 1930, 7142, 10758, 15414, 1942, 2518, 3028, 4233, 9431, 1012, 2063, 1032, 3]}, "items": [{"id": "p_4588", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_4589", "content": "mecamylamine [SEP] nicotine. Intraperitoneal administration of atropine, naloxone, mecamylamine, and hexamethonium to mice reduced catalepsy induced by a combi", "tokenized_content": [2, 10685, 27302, 3812, 3, 9303, 18, 13006, 4183, 1927, 24031, 16, 21926, 16, 10685, 27302, 3812, 16, 1930, 7142, 10758, 15414, 1942, 2518, 3028, 4233, 9431, 1012, 2719, 2007, 43, 3]}, "items": [{"id": "p_4589", "content": "Mecamylamine [SEP] A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine h", "score": 1, "type": null, "tokenized_content": [2, 10685, 27302, 3812, 3, 43, 20239, 8151, 1988, 1977, 2486, 14504, 2037, 1920, 8375, 6482, 1930, 17553, 1920, 2877, 17, 3068, 7104, 18, 10685, 27302, 3812, 50, 3]}]}
{"query": {"id": "q_4590", "content": "hexamethonium [SEP] itoneal administration of atropine, naloxone, mecamylamine, and hexamethonium to mice reduced catalepsy induced by a combination of morphine ", "tokenized_content": [2, 7142, 10758, 15414, 3, 21384, 7469, 4183, 1927, 24031, 16, 21926, 16, 10685, 27302, 3812, 16, 1930, 7142, 10758, 15414, 1942, 2518, 3028, 4233, 9431, 1012, 2719, 2007, 43, 3921, 3]}, "items": [{"id": "p_4590", "content": "Hexamethonium [SEP] A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gast", "score": 1, "type": null, "tokenized_content": [2, 7142, 10758, 15414, 3, 43, 20239, 13908, 8151, 3868, 6656, 1942, 1966, 1920, 29183, 12516, 1935, 14580, 18, 2176, 1977, 7865, 14504, 2037, 1920, 6215, 3]}]}
{"query": {"id": "q_4591", "content": "cardiotoxicity [SEP] Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxor", "tokenized_content": [2, 30490, 3, 3028, 30490, 1930, 10502, 11775, 4348, 1927, 19454, 17, 15358, 7169, 1924, 3]}, "items": [{"id": "p_4591", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4592", "content": "doxorubicin [SEP] icity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and", "tokenized_content": [2, 12377, 3, 25272, 3145, 1930, 10502, 11775, 4348, 1927, 19454, 17, 15358, 12377, 1930, 17135, 2452, 1956, 5552, 12377, 1930, 3]}, "items": [{"id": "p_4592", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4593", "content": "cyclophosphamide [SEP] ved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in ", "tokenized_content": [2, 17135, 3, 3428, 1007, 11775, 4348, 1927, 19454, 17, 15358, 12377, 1930, 17135, 2452, 1956, 5552, 12377, 1930, 17135, 1922, 3]}, "items": [{"id": "p_4593", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4594", "content": "breast cancer [SEP] clophosphamide in a randomized, multicenter trial of metastatic breast cancer.", "tokenized_content": [2, 3739, 2539, 3, 20000, 10647, 3508, 8527, 2261, 1922, 43, 5542, 16, 14620, 3046, 1927, 6476, 3739, 2539, 18, 3]}, "items": [{"id": "p_4594", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4595", "content": "Myocet [SEP] PURPOSE: To determine whether Myocet (liposome-encapsulated doxorubicin; The Liposome Company, Elan ", "tokenized_content": [2, 15924, 1972, 1031, 3, 5120, 30, 1942, 3415, 3053, 15924, 1972, 1031, 12, 19454, 17, 15358, 12377, 31, 1920, 19454, 12428, 16, 2349, 1928, 3]}, "items": [{"id": "p_4595", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4596", "content": "doxorubicin [SEP] PURPOSE: To determine whether Myocet (liposome-encapsulated doxorubicin; The Liposome Company, Elan Corporation, Princeton, NJ) in comb", "tokenized_content": [2, 12377, 3, 5120, 30, 1942, 3415, 3053, 15924, 1972, 1031, 12, 19454, 17, 15358, 12377, 31, 1920, 19454, 12428, 16, 2349, 1928, 12915, 16, 5946, 30119, 16, 11421, 13, 1922, 3]}, "items": [{"id": "p_4596", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4597", "content": "cyclophosphamide [SEP] e Company, Elan Corporation, Princeton, NJ) in combination with cyclophosphamide significantly reduces doxorubicin cardiotoxicity while providin", "tokenized_content": [2, 17135, 3, 47, 12428, 16, 2349, 1928, 12915, 16, 5946, 30119, 16, 11421, 13, 1922, 3921, 1956, 17135, 2567, 7268, 12377, 30490, 2679, 2867, 1921, 3]}, "items": [{"id": "p_4597", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4598", "content": "cardiotoxicity [SEP] ination with cyclophosphamide significantly reduces doxorubicin cardiotoxicity while providing comparable antitumor efficacy in first-line tre", "tokenized_content": [2, 30490, 3, 26851, 1929, 1956, 17135, 2567, 7268, 12377, 30490, 2679, 5453, 5596, 11775, 4348, 1922, 2561, 17, 2823, 2171, 3]}, "items": [{"id": "p_4598", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4599", "content": "breast cancer [SEP] arable antitumor efficacy in first-line treatment of metastatic breast cancer (MBC). PATIENTS AND METHODS: Two hundred ninety-seven patients ", "tokenized_content": [2, 3739, 2539, 3, 7165, 1952, 11775, 4348, 1922, 2561, 17, 2823, 2311, 1927, 6476, 3739, 2539, 12, 23742, 13, 18, 2132, 1930, 2860, 30, 2288, 8295, 18086, 17, 5260, 2132, 3]}, "items": [{"id": "p_4599", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4600", "content": "MBC [SEP] r efficacy in first-line treatment of metastatic breast cancer (MBC). PATIENTS AND METHODS: Two hundred ninety-seven patients with ", "tokenized_content": [2, 23742, 3, 60, 4348, 1922, 2561, 17, 2823, 2311, 1927, 6476, 3739, 2539, 12, 23742, 13, 18, 2132, 1930, 2860, 30, 2288, 8295, 18086, 17, 5260, 2132, 1956, 3]}, "items": [{"id": "p_4600", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4601", "content": "toxicity [SEP] n with cyclophosphamide significantly reduces doxorubicin cardiotoxicity while providing comparable antitumor efficacy in first-line tre", "tokenized_content": [2, 5532, 3, 56, 1956, 17135, 2567, 7268, 12377, 30490, 2679, 5453, 5596, 11775, 4348, 1922, 2561, 17, 2823, 2171, 3]}, "items": [{"id": "p_4601", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4602", "content": "Cardiotoxicity [SEP] ery 3 weeks until disease progression or unacceptable toxicity. Cardiotoxicity was defined by reductions in left-ventricular ejection fraction", "tokenized_content": [2, 30490, 3, 2668, 1012, 23, 3625, 4801, 2573, 4380, 2014, 27637, 5532, 18, 30490, 1982, 3608, 2007, 9350, 1922, 3506, 17, 6493, 13854, 3906, 3]}, "items": [{"id": "p_4602", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4603", "content": "congestive heart failure [SEP] ssessed by serial multigated radionuclide angiography scans, or congestive heart failure (CHF). Antitumor efficacy was assessed by objective tumor respo", "tokenized_content": [2, 20180, 4003, 4574, 3, 24773, 5590, 1919, 2007, 9285, 2779, 11886, 1919, 29428, 11676, 8581, 16, 2014, 20180, 4003, 4574, 12, 18307, 13, 18, 11775, 4348, 1982, 3683, 2007, 4470, 3]}, "items": [{"id": "p_4603", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4604", "content": "CHF [SEP] ed radionuclide angiography scans, or congestive heart failure (CHF). Antitumor efficacy was assessed by objective tumor response r", "tokenized_content": [2, 18307, 3, 3347, 29428, 11676, 8581, 16, 2014, 20180, 4003, 4574, 12, 18307, 13, 18, 11775, 4348, 1982, 3683, 2007, 4470, 2798, 2644, 60, 3]}, "items": [{"id": "p_4604", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4605", "content": "tumor [SEP] duces doxorubicin cardiotoxicity while providing comparable antitumor efficacy in first-line treatment of metastatic breast cancer (M", "tokenized_content": [2, 2798, 3, 10677, 1918, 12377, 30490, 2679, 5453, 5596, 11775, 4348, 1922, 2561, 17, 2823, 2311, 1927, 6476, 3739, 2539, 12, 55, 3]}, "items": [{"id": "p_4605", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4606", "content": "neutropenia [SEP]  hazard ratio, 5.04). MC patients also experienced less grade 4 neutropenia. Antitumor efficacy of MC versus AC was comparable: objective r", "tokenized_content": [2, 18005, 3, 7320, 3400, 16, 25, 18, 5228, 13, 18, 4110, 2132, 2222, 6090, 2941, 4927, 24, 18005, 18, 11775, 4348, 1927, 4110, 4072, 2000, 1982, 5596, 30, 4470, 60, 3]}, "items": [{"id": "p_4606", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_4607", "content": "BN 52021 [SEP] ive effect of a specific platelet-activating factor antagonist, BN 52021, on bupivacaine-induced cardiovascular impairments in rats.", "tokenized_content": [2, 11006, 20386, 4716, 3, 4370, 1021, 2495, 1927, 43, 2487, 7163, 17, 8019, 2991, 8151, 16, 11006, 20386, 4716, 16, 1990, 25473, 17, 2719, 5321, 12454, 1922, 3615, 18, 3]}, "items": [{"id": "p_4607", "content": "ginkgolide B [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7217, 1022, 23254, 24710, 44, 3, 3]}]}
{"query": {"id": "q_4608", "content": "bupivacaine [SEP]  a specific platelet-activating factor antagonist, BN 52021, on bupivacaine-induced cardiovascular impairments in rats.", "tokenized_content": [2, 25473, 3, 43, 2487, 7163, 17, 8019, 2991, 8151, 16, 11006, 20386, 4716, 16, 1990, 25473, 17, 2719, 5321, 12454, 1922, 3615, 18, 3]}, "items": [{"id": "p_4608", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_4609", "content": "cardiovascular impairments [SEP] -activating factor antagonist, BN 52021, on bupivacaine-induced cardiovascular impairments in rats.", "tokenized_content": [2, 5321, 12454, 3, 17, 8019, 2991, 8151, 16, 11006, 20386, 4716, 16, 1990, 25473, 17, 2719, 5321, 12454, 1922, 3615, 18, 3]}, "items": [{"id": "p_4609", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4610", "content": "bupivacaine [SEP] Administration of the local anaesthetic bupivacaine (1.5 or 2 mg/kg, i.v.) to rats elicited a marked decrease of me", "tokenized_content": [2, 25473, 3, 4183, 1927, 1920, 3076, 28818, 25473, 12, 21, 18, 25, 2014, 22, 2786, 19, 3621, 16, 51, 18, 64, 18, 13, 1942, 3615, 9856, 43, 4961, 3714, 1927, 3]}, "items": [{"id": "p_4610", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_4611", "content": "decrease of mean arterial blood pressure (MBP) [SEP] ic bupivacaine (1.5 or 2 mg/kg, i.v.) to rats elicited a marked decrease of mean arterial blood pressure (MBP) and heart rate (HR) leading to death (in 67% or 90% of animals ", "tokenized_content": [2, 3714, 1927, 2667, 6624, 2877, 3772, 12, 13312, 13, 3, 3996, 25473, 12, 21, 18, 25, 2014, 22, 2786, 19, 3621, 16, 51, 18, 64, 18, 13, 1942, 3615, 9856, 3]}, "items": [{"id": "p_4611", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4612", "content": "BN 52021 [SEP] ion of the specific platelet-activating factor (PAF) antagonist BN 52021 (10 mg/kg), 30 min before bupivacaine administration (2 mg/kg i", "tokenized_content": [2, 11006, 20386, 4716, 3, 4755, 1927, 1920, 2487, 7163, 17, 8019, 2991, 12, 16545, 13, 8151, 11006, 20386, 4716, 12, 2119, 2786, 19, 3621, 13, 16, 2627, 2360, 3119, 25473, 3]}, "items": [{"id": "p_4612", "content": "ginkgolide B [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7217, 1022, 23254, 24710, 44, 3, 3]}]}
{"query": {"id": "q_4613", "content": "decrease of MBP [SEP] e bupivacaine administration (2 mg/kg i.v.) suppressed both the decrease of MBP and HR. In contrast, doses of 1 mg/kg BN 52021 given 30 min bef", "tokenized_content": [2, 3714, 1927, 13312, 3, 47, 25473, 4183, 12, 22, 2786, 19, 3621, 51, 18, 64, 18, 13, 7657, 2321, 1920, 3714, 1927, 13312, 1930, 3668, 18, 1922, 3320, 16, 5312, 3]}, "items": [{"id": "p_4613", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4614", "content": "cardiovascular toxicity [SEP] 2021, a specific antagonist of PAF, against bupivacaine-induced cardiovascular toxicity. Thus, consistent with its direct effect on heart, PAF appears ", "tokenized_content": [2, 5321, 5532, 3, 17401, 1009, 16, 43, 2487, 8151, 1927, 16545, 16, 3316, 25473, 17, 2719, 5321, 5532, 18, 2842, 16, 3499, 1956, 2496, 3083, 2495, 1990, 4003, 16, 16545, 3]}, "items": [{"id": "p_4614", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4615", "content": "cardiovascular alterations [SEP] t on heart, PAF appears to be implicated in bupivacaine-induced cardiovascular alterations.", "tokenized_content": [2, 5321, 5996, 3, 62, 1990, 4003, 16, 16545, 5107, 1942, 1998, 6835, 1922, 25473, 17, 2719, 5321, 5996, 18, 3]}, "items": [{"id": "p_4615", "content": "Cardiovascular Abnormalities [SEP] Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 6754, 3, 9901, 16, 12911, 16, 2014, 5815, 13621, 1927, 1920, 5321, 2433, 16, 2710, 1920, 4003, 1930, 2877, 7208, 18, 3]}]}
{"query": {"id": "q_4616", "content": "Benzylacyclouridine [SEP] Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impa", "tokenized_content": [2, 17605, 23689, 2257, 5802, 3, 17605, 23689, 2257, 5802, 28817, 6352, 15072, 28935, 16408, 2053, 17, 2719, 6599, 6412, 2979, 2754, 1019, 3]}, "items": [{"id": "p_4616", "content": "5-benzylacyclouridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 17605, 23689, 2257, 5802, 3, 3]}]}
{"query": {"id": "q_4617", "content": "azidothymidine [SEP] Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human imm", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 17605, 23689, 2257, 5802, 28817, 6352, 15072, 28935, 16408, 2053, 17, 2719, 6599, 6412, 2979, 6159, 1927, 2246, 17, 2616, 4960, 3]}, "items": [{"id": "p_4617", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_4618", "content": "marrow suppression [SEP] Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activit", "tokenized_content": [2, 6599, 6412, 3, 17605, 23689, 2257, 5802, 28817, 6352, 15072, 28935, 16408, 2053, 17, 2719, 6599, 6412, 2979, 6159, 1927, 2246, 17, 2616, 13141, 3413, 2196, 1932, 3]}, "items": [{"id": "p_4618", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_4619", "content": "immunodeficiency [SEP] ine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.", "tokenized_content": [2, 13141, 3, 11116, 17, 2719, 6599, 6412, 2979, 6159, 1927, 2246, 17, 2616, 13141, 3413, 2455, 18, 3]}, "items": [{"id": "p_4619", "content": "Immunologic Deficiency Syndromes [SEP] Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21049, 6179, 12688, 3, 12688, 1922, 2154, 2276, 1977, 43, 6179, 2014, 7374, 1922, 1920, 3531, 1927, 7611, 16, 3108, 3689, 2014, 16601, 18, 3]}]}
{"query": {"id": "q_4620", "content": "uridine [SEP] Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (A", "tokenized_content": [2, 26104, 3, 2502, 5329, 3295, 1927, 26104, 12, 3674, 1007, 13, 2162, 2252, 2568, 1942, 4412, 16, 1922, 3596, 16, 6352, 15072, 28935, 16408, 2053, 12, 43, 3]}, "items": [{"id": "p_4620", "content": "Uridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26104, 3, 3]}]}
{"query": {"id": "q_4621", "content": "Urd [SEP] Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-i", "tokenized_content": [2, 3674, 1007, 3, 2502, 5329, 3295, 1927, 26104, 12, 3674, 1007, 13, 2162, 2252, 2568, 1942, 4412, 16, 1922, 3596, 16, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 17, 3]}, "items": [{"id": "p_4621", "content": "Uridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26104, 3, 3]}]}
{"query": {"id": "q_4622", "content": "azidothymidine [SEP] ations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progen", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 2019, 2443, 1927, 26104, 12, 3674, 1007, 13, 2162, 2252, 2568, 1942, 4412, 16, 1922, 3596, 16, 6352, 15072, 28935, 16408, 2053, 12, 28301, 3]}, "items": [{"id": "p_4622", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_4623", "content": "AZT [SEP] e (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progenitor ", "tokenized_content": [2, 28301, 3, 47, 12, 3674, 1007, 13, 2162, 2252, 2568, 1942, 4412, 16, 1922, 3596, 16, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 17, 2719, 3523, 1927, 2616, 19235, 3]}, "items": [{"id": "p_4623", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_4624", "content": "immunodeficiency [SEP] macrophage progenitor cells without impairment of its antihuman immunodeficiency virus (HIV) activity. Because of the clinical toxicities associ", "tokenized_content": [2, 13141, 3, 8088, 9411, 2094, 2979, 6159, 1927, 2496, 12946, 19083, 13141, 3413, 12, 3525, 13, 2455, 18, 2882, 1927, 1920, 2535, 15251, 2293, 3]}, "items": [{"id": "p_4624", "content": "Immunologic Deficiency Syndromes [SEP] Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21049, 6179, 12688, 3, 12688, 1922, 2154, 2276, 1977, 43, 6179, 2014, 7374, 1922, 1920, 3531, 1927, 7611, 16, 3108, 3689, 2014, 16601, 18, 3]}]}
{"query": {"id": "q_4625", "content": "toxicities [SEP]  immunodeficiency virus (HIV) activity. Because of the clinical toxicities associated with chronic Urd administration, the ability of benz", "tokenized_content": [2, 15251, 3, 13141, 3413, 12, 3525, 13, 2455, 18, 2882, 1927, 1920, 2535, 15251, 2458, 1956, 3724, 3674, 1007, 4183, 16, 1920, 3682, 1927, 7334, 3]}, "items": [{"id": "p_4625", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4626", "content": "benzylacyclouridine [SEP] ties associated with chronic Urd administration, the ability of benzylacyclouridine (BAU) to effect, in vivo, AZT-induced anemia and leukopenia was", "tokenized_content": [2, 17605, 23689, 2257, 5802, 3, 25439, 2458, 1956, 3724, 3674, 1007, 4183, 16, 1920, 3682, 1927, 17605, 23689, 2257, 5802, 12, 6813, 1032, 13, 1942, 2495, 16, 1922, 3597, 16, 3]}, "items": [{"id": "p_4626", "content": "5-benzylacyclouridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 17605, 23689, 2257, 5802, 3, 3]}]}
{"query": {"id": "q_4627", "content": "BAU [SEP] chronic Urd administration, the ability of benzylacyclouridine (BAU) to effect, in vivo, AZT-induced anemia and leukopenia was asse", "tokenized_content": [2, 6813, 1032, 3, 3724, 3674, 1007, 4183, 16, 1920, 3682, 1927, 17605, 23689, 2257, 5802, 12, 6813, 1032, 13, 1942, 2495, 16, 1922, 3597, 16, 28301, 17, 2719, 10679, 1930, 3]}, "items": [{"id": "p_4627", "content": "5-benzylacyclouridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 17605, 23689, 2257, 5802, 3, 3]}]}
{"query": {"id": "q_4628", "content": "anemia [SEP] ty of benzylacyclouridine (BAU) to effect, in vivo, AZT-induced anemia and leukopenia was assessed. This agent inhibits Urd catabolism", "tokenized_content": [2, 10679, 3, 6227, 1927, 17605, 23689, 2257, 5802, 12, 6813, 1032, 13, 1942, 2495, 16, 1922, 3597, 16, 28301, 17, 2719, 10679, 1930, 5104, 12903, 1982, 3683, 18, 2052, 5899, 3]}, "items": [{"id": "p_4628", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_4629", "content": "leukopenia [SEP] lacyclouridine (BAU) to effect, in vivo, AZT-induced anemia and leukopenia was assessed. This agent inhibits Urd catabolism and, in vivo, ", "tokenized_content": [2, 5104, 12903, 3, 7511, 3143, 2257, 5802, 12, 6813, 1032, 13, 1942, 2495, 16, 1922, 3597, 16, 28301, 17, 2719, 10679, 1930, 5104, 12903, 1982, 3683, 18, 2052, 5899, 7042, 3]}, "items": [{"id": "p_4629", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_4630", "content": "toxicity [SEP] ntration of Urd in a dose-dependent manner, without Urd-related toxicity. In mice rendered anemic and leukopenic by the administration o", "tokenized_content": [2, 5532, 3, 20517, 1943, 1927, 3674, 1007, 1922, 43, 3253, 17, 3100, 5222, 16, 2979, 3674, 1007, 17, 2712, 5532, 18, 1922, 2518, 18416, 9860, 4913, 1930, 5104, 4907, 19730, 3]}, "items": [{"id": "p_4630", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4631", "content": "anemic [SEP] ependent manner, without Urd-related toxicity. In mice rendered anemic and leukopenic by the administration of AZT for 28 days in drin", "tokenized_content": [2, 9860, 4913, 3, 2630, 2663, 5222, 16, 2979, 3674, 1007, 17, 2712, 5532, 18, 1922, 2518, 18416, 9860, 4913, 1930, 5104, 4907, 19730, 2007, 1920, 4183, 1927, 28301, 1958, 3158, 3]}, "items": [{"id": "p_4631", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_4632", "content": "leukopenic [SEP] nner, without Urd-related toxicity. In mice rendered anemic and leukopenic by the administration of AZT for 28 days in drinking water (1.5", "tokenized_content": [2, 5104, 4907, 19730, 3, 11450, 1915, 16, 2979, 3674, 1007, 17, 2712, 5532, 18, 1922, 2518, 18416, 9860, 4913, 1930, 5104, 4907, 19730, 2007, 1920, 4183, 1927, 28301, 1958, 3158, 3]}, "items": [{"id": "p_4632", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_4633", "content": "marrow toxicity [SEP]  from the onset of drug administration, BAU reduced AZT-induced marrow toxicity. In vitro, at a concentration of 100 mumol/L, BAU possesses min", "tokenized_content": [2, 6599, 5532, 3, 2037, 1920, 4727, 1927, 2838, 4183, 16, 6813, 1032, 3028, 28301, 17, 2719, 6599, 5532, 18, 1922, 3596, 16, 2019, 43, 3110, 1927, 2813, 27078, 19, 54, 3]}, "items": [{"id": "p_4633", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_4634", "content": "Cyclophosphamide [SEP] Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral ap", "tokenized_content": [2, 17135, 3, 17135, 17, 2719, 9446, 3678, 1922, 14789, 17, 9898, 11993, 3615, 30, 5343, 2100, 3]}, "items": [{"id": "p_4634", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4635", "content": "cystitis [SEP] Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new m", "tokenized_content": [2, 9446, 3678, 3, 17135, 17, 2719, 9446, 3678, 1922, 14789, 17, 9898, 11993, 3615, 30, 5343, 2998, 1942, 43, 2814, 55, 3]}, "items": [{"id": "p_4635", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_4636", "content": "visceral pain [SEP] ly-moving conscious rats: behavioral approach to a new model of visceral pain.", "tokenized_content": [2, 12708, 3594, 3, 7518, 17, 9898, 11993, 3615, 30, 5343, 2998, 1942, 43, 2814, 2322, 1927, 12708, 3594, 18, 3]}, "items": [{"id": "p_4636", "content": "Visceral Pain [SEP] Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It", "score": 1, "type": null, "tokenized_content": [2, 12708, 3594, 3, 3594, 14391, 2037, 4495, 7393, 12, 12108, 1019, 13, 2458, 1956, 13725, 12616, 12, 9396, 1924, 31, 25386, 1941, 31, 13759, 31, 1930, 13954, 13, 18, 2176, 3]}]}
{"query": {"id": "q_4637", "content": "visceral pain [SEP] PURPOSE: To develop a model of visceral pain in rats using a behavioral approach. Cyclophosphamide (CP), an ", "tokenized_content": [2, 12708, 3594, 3, 5120, 30, 1942, 2392, 43, 2322, 1927, 12708, 3594, 1922, 3615, 2193, 43, 5343, 2998, 18, 17135, 12, 4244, 13, 16, 1925, 3]}, "items": [{"id": "p_4637", "content": "Visceral Pain [SEP] Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It", "score": 1, "type": null, "tokenized_content": [2, 12708, 3594, 3, 3594, 14391, 2037, 4495, 7393, 12, 12108, 1019, 13, 2458, 1956, 13725, 12616, 12, 9396, 1924, 31, 25386, 1941, 31, 13759, 31, 1930, 13954, 13, 18, 2176, 3]}]}
{"query": {"id": "q_4638", "content": "Cyclophosphamide [SEP] p a model of visceral pain in rats using a behavioral approach. Cyclophosphamide (CP), an antitumoral agent known to produce toxic effects on th", "tokenized_content": [2, 17135, 3, 58, 43, 2322, 1927, 12708, 3594, 1922, 3615, 2193, 43, 5343, 2998, 18, 17135, 12, 4244, 13, 16, 1925, 11775, 1923, 5899, 3171, 1942, 5074, 6161, 2564, 1990, 3]}, "items": [{"id": "p_4638", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4639", "content": "CP [SEP] ral pain in rats using a behavioral approach. Cyclophosphamide (CP), an antitumoral agent known to produce toxic effects on the bl", "tokenized_content": [2, 4244, 3, 15906, 3594, 1922, 3615, 2193, 43, 5343, 2998, 18, 17135, 12, 4244, 13, 16, 1925, 11775, 1923, 5899, 3171, 1942, 5074, 6161, 2564, 1990, 1920, 2266, 3]}, "items": [{"id": "p_4639", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4640", "content": "acrolein [SEP] c effects on the bladder wall through its main toxic metabolite acrolein, was used to induce cystitis. MATERIALS AND METHODS: CP was adm", "tokenized_content": [2, 10428, 2456, 1921, 3, 45, 2564, 1990, 1920, 7821, 4821, 2596, 2496, 2730, 6161, 9483, 10428, 2456, 1921, 16, 1982, 2251, 1942, 4769, 9446, 3678, 18, 4751, 1930, 2860, 30, 3]}, "items": [{"id": "p_4640", "content": "Acrolein [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10428, 2456, 1921, 3, 3]}]}
{"query": {"id": "q_4641", "content": "cystitis [SEP]  through its main toxic metabolite acrolein, was used to induce cystitis. MATERIALS AND METHODS: CP was administered at doses of 50, 100", "tokenized_content": [2, 9446, 3678, 3, 2596, 2496, 2730, 6161, 9483, 10428, 2456, 1921, 16, 1982, 2251, 1942, 4769, 9446, 3678, 18, 4751, 1930, 2860, 30, 4244, 1982, 5254, 2019, 5312, 1927, 2761, 3]}, "items": [{"id": "p_4641", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_4642", "content": "morphine [SEP] le rats, and their behavior observed and scored. The effects of morphine (0.5 to 4 mg./kg. i.v.) on CP-induced behavioral modifications ", "tokenized_content": [2, 11553, 3, 2071, 3615, 16, 1930, 2310, 3379, 2528, 1930, 9032, 18, 1920, 2564, 1927, 11553, 12, 20, 18, 25, 1942, 24, 2786, 18, 19, 3621, 18, 51, 18, 64, 3]}, "items": [{"id": "p_4642", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4643", "content": "naloxone [SEP] havioral modifications were tested administered alone and after naloxone (1 mg./kg. s.c.). In addition, 90 minutes after CP injection, t", "tokenized_content": [2, 21926, 3, 25838, 2666, 1923, 6920, 1985, 3620, 5254, 4298, 1930, 2256, 21926, 12, 21, 2786, 18, 19, 3621, 18, 61, 18, 45, 18, 13, 18, 1922, 2459, 16, 3865, 3]}, "items": [{"id": "p_4643", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_4644", "content": "Morphine [SEP] rease, closing of the eyes and occurrence of specific postures. Morphine dose-dependently reversed these behavioral disorders. A dose of", "tokenized_content": [2, 11553, 3, 4196, 1021, 16, 20451, 1927, 1920, 7127, 1930, 6564, 1927, 2487, 17858, 1036, 18, 11553, 3253, 17, 19898, 9432, 2144, 5343, 4414, 18, 43, 3253, 1927, 3]}, "items": [{"id": "p_4644", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4645", "content": "behavioral disorders [SEP]  of specific postures. Morphine dose-dependently reversed these behavioral disorders. A dose of 0.5 mg./kg. produced a reduction of almost 50% of th", "tokenized_content": [2, 5343, 4414, 3, 1927, 2487, 17858, 1036, 18, 11553, 3253, 17, 19898, 9432, 2144, 5343, 4414, 18, 43, 3253, 1927, 20, 18, 25, 2786, 18, 19, 3621, 18, 4152, 43, 3]}, "items": [{"id": "p_4645", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4646", "content": "edema [SEP] cations of the bladder wall, such as chorionic and muscle layer edema, were observed. In female rats, CP 200 mg./kg. i.p. produced th", "tokenized_content": [2, 10144, 3, 16525, 1927, 1920, 7821, 4821, 16, 2427, 1966, 28776, 1930, 3760, 4757, 10144, 16, 1985, 2528, 18, 1922, 4232, 3615, 16, 4244, 2191, 2786, 18, 19, 3621, 18, 3]}, "items": [{"id": "p_4646", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_4647", "content": "painful syndromes [SEP] mmatory visceral pain, allowing a better understanding of these painful syndromes and thus a better therapeutic approach to them.", "tokenized_content": [2, 15806, 12688, 3, 29025, 27708, 12708, 3594, 16, 7201, 43, 3807, 4339, 1927, 2144, 15806, 12688, 1930, 2842, 43, 3807, 4272, 2998, 1942, 3581, 18, 3]}, "items": [{"id": "p_4647", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4648", "content": "Hyperalgesia [SEP] Hyperalgesia and myoclonus in terminal cancer patients treated with continuo", "tokenized_content": [2, 21525, 3, 21525, 1930, 15924, 2223, 1916, 1957, 1922, 4262, 2539, 2132, 2868, 1956, 3884, 1037, 3]}, "items": [{"id": "p_4648", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4649", "content": "myoclonus [SEP] Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 21525, 1930, 15924, 2223, 1916, 1957, 1922, 4262, 2539, 2132, 2868, 1956, 4798, 7307, 3]}, "items": [{"id": "p_4649", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_4650", "content": "cancer [SEP] Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine.", "tokenized_content": [2, 2539, 3, 21525, 1930, 15924, 2223, 1916, 1957, 1922, 4262, 2539, 2132, 2868, 1956, 4798, 7307, 11553, 18, 3]}, "items": [{"id": "p_4650", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4651", "content": "morphine [SEP] in terminal cancer patients treated with continuous intravenous morphine.", "tokenized_content": [2, 11553, 3, 1922, 4262, 2539, 2132, 2868, 1956, 4798, 7307, 11553, 18, 3]}, "items": [{"id": "p_4651", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4652", "content": "cancer [SEP] Eight cancer patients in the terminal stages of the disease treated with hig", "tokenized_content": [2, 2539, 3, 5066, 2539, 2132, 1922, 1920, 4262, 5143, 1927, 1920, 2573, 2868, 1956, 21340, 3]}, "items": [{"id": "p_4652", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4653", "content": "morphine [SEP] al stages of the disease treated with high doses of intravenous morphine developed hyperalgesia. All cases were retrospectively sampled ", "tokenized_content": [2, 11553, 3, 1969, 5143, 1927, 1920, 2573, 2868, 1956, 2149, 5312, 1927, 7307, 11553, 3530, 21525, 18, 2136, 2919, 1985, 11601, 8783, 3]}, "items": [{"id": "p_4653", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_4654", "content": "hyperalgesia [SEP] sease treated with high doses of intravenous morphine developed hyperalgesia. All cases were retrospectively sampled from three different ho", "tokenized_content": [2, 21525, 3, 6743, 1021, 2868, 1956, 2149, 5312, 1927, 7307, 11553, 3530, 21525, 18, 2136, 2919, 1985, 11601, 8783, 2037, 2559, 2413, 6673, 3]}, "items": [{"id": "p_4654", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4655", "content": "hyperesthesia [SEP]  Copenhagen. Five patients developed universal hyperalgesia and hyperesthesia which in 2 cases were accompanied by myoclonus. In 3 patients a", "tokenized_content": [2, 24004, 2156, 4483, 2126, 3, 16955, 21677, 4079, 18, 3628, 2132, 3530, 10321, 21525, 1930, 24004, 2156, 4483, 2126, 2154, 1922, 22, 2919, 1985, 7936, 2007, 15924, 2223, 1916, 1957, 3]}, "items": [{"id": "p_4655", "content": "Hyperesthesia [SEP] Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24004, 2156, 4483, 2126, 3, 2502, 3802, 1942, 11276, 4177, 2810, 1942, 43, 9597, 4683, 2014, 1925, 2502, 2644, 1942, 5458, 18, 3]}]}
{"query": {"id": "q_4656", "content": "myoclonus [SEP] ralgesia and hyperesthesia which in 2 cases were accompanied by myoclonus. In 3 patients a pre-existing neuralgia increased to excruciati", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 15906, 2286, 2126, 1930, 24004, 2156, 4483, 2126, 2154, 1922, 22, 2919, 1985, 7936, 2007, 15924, 2223, 1916, 1957, 18, 1922, 23, 2132, 43, 2097, 3]}, "items": [{"id": "p_4656", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_4657", "content": "neuralgia [SEP] ses were accompanied by myoclonus. In 3 patients a pre-existing neuralgia increased to excruciating intensity and in 2 of these cases myo", "tokenized_content": [2, 5181, 11966, 3, 9924, 1985, 7936, 2007, 15924, 2223, 1916, 1957, 18, 1922, 23, 2132, 43, 2097, 17, 6124, 5181, 11966, 2502, 1942, 3619, 3176, 3349, 2287, 4266, 1930, 1922, 3]}, "items": [{"id": "p_4657", "content": "Neuralgia [SEP] Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5181, 11966, 3, 10702, 2014, 3546, 1941, 3594, 1988, 5110, 4231, 1920, 4914, 2014, 3282, 1927, 43, 5009, 2014, 13598, 5507, 18, 3]}]}
{"query": {"id": "q_4658", "content": "vancomycin [SEP] A prospective study of adverse reactions associated with vancomycin therapy.", "tokenized_content": [2, 16100, 3, 43, 6315, 2161, 1927, 5246, 5298, 2458, 1956, 16100, 3181, 18, 3]}, "items": [{"id": "p_4658", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_4659", "content": "vancomycin [SEP] A prospective evaluation of the efficacy and safety of vancomycin was conducted in 54 consecutive patients over a 16-month period", "tokenized_content": [2, 16100, 3, 43, 6315, 4391, 1927, 1920, 4348, 1930, 5407, 1927, 16100, 1982, 3609, 1922, 4584, 7351, 2132, 2338, 43, 2641, 17, 2935, 3047, 3]}, "items": [{"id": "p_4659", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_4660", "content": "Vancomycin [SEP] as conducted in 54 consecutive patients over a 16-month period. Vancomycin was curative in 95% of 43 patients with proven infection. Drugs", "tokenized_content": [2, 16100, 3, 1966, 3609, 1922, 4584, 7351, 2132, 2338, 43, 2641, 17, 2935, 3047, 18, 16100, 1982, 15488, 1922, 3002, 9, 1927, 3941, 2132, 1956, 9253, 2909, 18, 4195, 3]}, "items": [{"id": "p_4660", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_4661", "content": "infection [SEP] riod. Vancomycin was curative in 95% of 43 patients with proven infection. Drugs were ceased in six patients because of adverse reactions", "tokenized_content": [2, 2909, 3, 23017, 1007, 18, 16100, 1982, 15488, 1922, 3002, 9, 1927, 3941, 2132, 1956, 9253, 2909, 18, 4195, 1985, 14292, 4127, 1007, 1922, 3798, 2132, 2882, 1927, 5246, 5298, 3]}, "items": [{"id": "p_4661", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_4662", "content": "thrombophlebitis [SEP]  vancomycin was considered the likely cause. Reactions included thrombophlebitis (20 of 54 patients), rash (4 of 54), nephrotoxicity (4 of 50), ", "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 16100, 1982, 3311, 1920, 3205, 3936, 18, 5298, 3063, 16379, 2102, 1952, 5443, 1937, 12, 2036, 1927, 4584, 2132, 13, 16, 18469, 12, 24, 3]}, "items": [{"id": "p_4662", "content": "Thrombophlebitis [SEP] Inflammation of a vein associated with a blood clot (THROMBUS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 4531, 1927, 43, 7920, 2458, 1956, 43, 2877, 15053, 12, 16705, 13, 18, 3]}]}
{"query": {"id": "q_4663", "content": "rash [SEP] cause. Reactions included thrombophlebitis (20 of 54 patients), rash (4 of 54), nephrotoxicity (4 of 50), proteinuria (1 of 50) and ", "tokenized_content": [2, 18469, 3, 3936, 18, 5298, 3063, 16379, 2102, 1952, 5443, 1937, 12, 2036, 1927, 4584, 2132, 13, 16, 18469, 12, 24, 1927, 4584, 13, 16, 27880, 12, 24, 1927, 2761, 3]}, "items": [{"id": "p_4663", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_4664", "content": "nephrotoxicity [SEP]  included thrombophlebitis (20 of 54 patients), rash (4 of 54), nephrotoxicity (4 of 50), proteinuria (1 of 50) and ototoxicity (1 of 11 patie", "tokenized_content": [2, 27880, 3, 3063, 16379, 2102, 1952, 5443, 1937, 12, 2036, 1927, 4584, 2132, 13, 16, 18469, 12, 24, 1927, 4584, 13, 16, 27880, 12, 24, 1927, 2761, 13, 16, 15831, 3]}, "items": [{"id": "p_4664", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4665", "content": "proteinuria [SEP]  (20 of 54 patients), rash (4 of 54), nephrotoxicity (4 of 50), proteinuria (1 of 50) and ototoxicity (1 of 11 patients tested by audiometr", "tokenized_content": [2, 15831, 3, 12, 2036, 1927, 4584, 2132, 13, 16, 18469, 12, 24, 1927, 4584, 13, 16, 27880, 12, 24, 1927, 2761, 13, 16, 15831, 12, 21, 1927, 2761, 13, 1930, 3]}, "items": [{"id": "p_4665", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_4666", "content": "ototoxicity [SEP]  (4 of 54), nephrotoxicity (4 of 50), proteinuria (1 of 50) and ototoxicity (1 of 11 patients tested by audiometry). Thrombophlebitis occur", "tokenized_content": [2, 7608, 11930, 3, 12, 24, 1927, 4584, 13, 16, 27880, 12, 24, 1927, 2761, 13, 16, 15831, 12, 21, 1927, 2761, 13, 1930, 7608, 11930, 12, 21, 1927, 2513, 2132, 3]}, "items": [{"id": "p_4666", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_4667", "content": "Thrombophlebitis [SEP] of 50) and ototoxicity (1 of 11 patients tested by audiometry). Thrombophlebitis occurred only with infusion through peripheral cannulae; nephro", "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 1927, 2761, 13, 1930, 7608, 11930, 12, 21, 1927, 2513, 2132, 3620, 2007, 18609, 14578, 6907, 13, 18, 16379, 2102, 1952, 5443, 1937, 4807, 3]}, "items": [{"id": "p_4667", "content": "Thrombophlebitis [SEP] Inflammation of a vein associated with a blood clot (THROMBUS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16379, 2102, 1952, 5443, 1937, 3, 4531, 1927, 43, 7920, 2458, 1956, 43, 2877, 15053, 12, 16705, 13, 18, 3]}]}
{"query": {"id": "q_4668", "content": "aminoglycoside [SEP] toxicity and ototoxicity were confined to patients receiving an aminoglycoside plus vancomycin. We conclude that vancomycin, administered appr", "tokenized_content": [2, 23029, 8028, 3, 5532, 1930, 7608, 11930, 1985, 13184, 1942, 2132, 5962, 1925, 23029, 8028, 5390, 16100, 18, 2038, 7676, 1988, 16100, 16, 5254, 2847, 1005, 3]}, "items": [{"id": "p_4668", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_4669", "content": "infections [SEP] nistered appropriately, constitutes safe, effective therapy for infections caused by susceptible bacteria.", "tokenized_content": [2, 5024, 3, 17299, 3188, 14221, 16, 14879, 7672, 16, 3655, 3181, 1958, 5024, 4189, 2007, 7819, 4802, 18, 3]}, "items": [{"id": "p_4669", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_4670", "content": "dopamine [SEP] Blockade of both D-1 and D-2 dopamine receptors may induce catalepsy in mice.", "tokenized_content": [2, 7964, 3, 9847, 1927, 2321, 46, 17, 21, 1930, 46, 17, 22, 7964, 4086, 2278, 4769, 4233, 9431, 1012, 1922, 2518, 18, 3]}, "items": [{"id": "p_4670", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4671", "content": "catalepsy [SEP] Blockade of both D-1 and D-2 dopamine receptors may induce catalepsy in mice.", "tokenized_content": [2, 4233, 9431, 1012, 3, 9847, 1927, 2321, 46, 17, 21, 1930, 46, 17, 22, 7964, 4086, 2278, 4769, 4233, 9431, 1012, 1922, 2518, 18, 3]}, "items": [{"id": "p_4671", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4672", "content": "catalepsy [SEP] 1. The catalepsy induced by dopamine antagonists has been tested and the possibl", "tokenized_content": [2, 4233, 9431, 1012, 3, 21, 18, 1920, 4233, 9431, 1012, 2719, 2007, 7964, 10515, 2258, 2252, 3620, 1930, 1920, 2776, 2023, 1024, 3]}, "items": [{"id": "p_4672", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4673", "content": "dopamine [SEP] 1. The catalepsy induced by dopamine antagonists has been tested and the possible dopamine subtypes ", "tokenized_content": [2, 7964, 3, 21, 18, 1920, 4233, 9431, 1012, 2719, 2007, 7964, 10515, 2258, 2252, 3620, 1930, 1920, 3216, 7964, 8160, 3]}, "items": [{"id": "p_4673", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4674", "content": "Dopamine [SEP] ible dopamine subtypes involved in catalepsy was determined. 2. Dopamine antagonist fluphenazine, D-1 antagonist SCH 23390 or D-2 antago", "tokenized_content": [2, 7964, 3, 6180, 1952, 7964, 8160, 3286, 1922, 4233, 9431, 1012, 1982, 3180, 18, 22, 18, 7964, 8151, 2848, 17616, 10119, 16, 46, 17, 21, 8151, 2966, 19598, 5124, 2014, 3]}, "items": [{"id": "p_4674", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4675", "content": "fluphenazine [SEP] es involved in catalepsy was determined. 2. Dopamine antagonist fluphenazine, D-1 antagonist SCH 23390 or D-2 antagonist sulpiride induced c", "tokenized_content": [2, 2848, 17616, 10119, 3, 2376, 3286, 1922, 4233, 9431, 1012, 1982, 3180, 18, 22, 18, 7964, 8151, 2848, 17616, 10119, 16, 46, 17, 21, 8151, 2966, 19598, 5124, 2014, 46, 3]}, "items": [{"id": "p_4675", "content": "Fluphenazine [SEP] A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 2848, 17616, 10119, 3, 43, 3037, 30354, 2053, 2251, 1922, 1920, 2311, 1927, 9855, 1918, 18, 2496, 3879, 1930, 7947, 2032, 4933, 2551, 1942, 2690, 1927, 4891, 2216, 3368, 22030, 2912, 18, 3]}]}
{"query": {"id": "q_4676", "content": "SCH 23390 [SEP] determined. 2. Dopamine antagonist fluphenazine, D-1 antagonist SCH 23390 or D-2 antagonist sulpiride induced catalepsy. The effect of fl", "tokenized_content": [2, 2966, 19598, 5124, 3, 3180, 18, 22, 18, 7964, 8151, 2848, 17616, 10119, 16, 46, 17, 21, 8151, 2966, 19598, 5124, 2014, 46, 17, 22, 8151, 9596, 10984, 20332, 1021, 3]}, "items": [{"id": "p_4676", "content": "SCH 23390 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2966, 19598, 5124, 3, 3]}]}
{"query": {"id": "q_4677", "content": "sulpiride [SEP] gonist fluphenazine, D-1 antagonist SCH 23390 or D-2 antagonist sulpiride induced catalepsy. The effect of fluphenazine and sulpiride was", "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 8239, 2184, 2848, 17616, 10119, 16, 46, 17, 21, 8151, 2966, 19598, 5124, 2014, 46, 17, 22, 8151, 9596, 10984, 20332, 1021, 2719, 4233, 9431, 3]}, "items": [{"id": "p_4677", "content": "Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.", "score": 1, "type": null, "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 43, 7964, 8631, 17, 3148, 8151, 18, 2176, 2258, 2252, 2251, 25058, 1966, 1925, 14183, 16, 17581, 16, 1930, 1966, 43, 15486, 8379, 18, 3]}]}
{"query": {"id": "q_4678", "content": "SKF 38393 [SEP] sulpiride did not induce catalepsy potentiation. 3. D-1 agonist SKF 38393 or D-2 agonist quinpirole decreased the catalepsy induced by fl", "tokenized_content": [2, 3097, 1038, 27787, 11436, 3, 9596, 10984, 20332, 1021, 2811, 2084, 4769, 4233, 9431, 1012, 16020, 18, 23, 18, 46, 17, 21, 7829, 3097, 1038, 27787, 11436, 2014, 46, 17, 3]}, "items": [{"id": "p_4678", "content": "2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine [SEP] A selective D1 dopamine receptor agonist used primarily as a research tool.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 23, 16, 24, 16, 25, 17, 21196, 17, 27, 16, 28, 17, 20684, 17, 21, 17, 7971, 17, 5189, 17, 23, 17, 7334, 25360, 3, 43, 5328, 8524, 7964, 3148, 7829, 2251, 5985, 1966, 43, 2659, 5229, 18, 3]}]}
{"query": {"id": "q_4679", "content": "quinpirole [SEP] catalepsy potentiation. 3. D-1 agonist SKF 38393 or D-2 agonist quinpirole decreased the catalepsy induced by fluphenazine, SCH 23390 or s", "tokenized_content": [2, 9012, 10984, 15828, 3, 4233, 9431, 1012, 16020, 18, 23, 18, 46, 17, 21, 7829, 3097, 1038, 27787, 11436, 2014, 46, 17, 22, 7829, 9012, 10984, 15828, 3261, 1920, 4233, 3]}, "items": [{"id": "p_4679", "content": "Quinpirole [SEP] A dopamine D2/D3 receptor agonist.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9012, 10984, 15828, 3, 43, 7964, 8631, 19, 11319, 3148, 7829, 18, 3]}]}
{"query": {"id": "q_4680", "content": "Dextran [SEP] Dextran-etodolac conjugates: synthesis, in vitro and in vivo evaluation", "tokenized_content": [2, 15195, 3, 15195, 17, 2140, 1986, 10173, 1030, 14749, 30, 4271, 16, 1922, 3596, 1930, 1922, 3597, 4391, 3]}, "items": [{"id": "p_4680", "content": "Dextrans [SEP] A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagu", "score": 1, "type": null, "tokenized_content": [2, 15195, 1036, 3, 43, 2210, 1927, 3817, 11039, 3915, 2007, 4908, 4802, 18, 15195, 1036, 2032, 2251, 25058, 1966, 3582, 3776, 7305, 2045, 1930, 11693, 2006, 1032, 3]}]}
{"query": {"id": "q_4681", "content": "etodolac [SEP] Dextran-etodolac conjugates: synthesis, in vitro and in vivo evaluation.", "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 15195, 17, 2140, 1986, 10173, 1030, 14749, 30, 4271, 16, 1922, 3596, 1930, 1922, 3597, 4391, 18, 3]}, "items": [{"id": "p_4681", "content": "Etodolac [SEP] A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in ", "score": 1, "type": null, "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 6828, 14501, 1930, 2246, 18956, 7635, 3879, 18, 2176, 2258, 2252, 2522, 1942, 1998, 3655, 1922, 3]}]}
{"query": {"id": "q_4682", "content": "Etodolac [SEP] Etodolac (E), is a non-narcotic analgesic and antiinflammatory drug. A b", "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 2140, 1986, 10173, 1030, 12, 47, 13, 16, 1977, 43, 2447, 17, 22872, 3153, 14501, 1930, 2246, 9899, 2838, 18, 43, 44, 3]}, "items": [{"id": "p_4682", "content": "Etodolac [SEP] A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in ", "score": 1, "type": null, "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 6828, 14501, 1930, 2246, 18956, 7635, 3879, 18, 2176, 2258, 2252, 2522, 1942, 1998, 3655, 1922, 3]}]}
{"query": {"id": "q_4683", "content": "E [SEP] Etodolac (E), is a non-narcotic analgesic and antiinflammatory dr", "tokenized_content": [2, 47, 3, 2140, 1986, 10173, 1030, 12, 47, 13, 16, 1977, 43, 2447, 17, 22872, 3153, 14501, 1930, 2246, 9899, 2324, 3]}, "items": [{"id": "p_4683", "content": "Etodolac [SEP] A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in ", "score": 1, "type": null, "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 6828, 14501, 1930, 2246, 18956, 7635, 3879, 18, 2176, 2258, 2252, 2522, 1942, 1998, 3655, 1922, 3]}]}
{"query": {"id": "q_4684", "content": "dextran [SEP] ic analgesic and antiinflammatory drug. A biodegradable polymer dextran has been utilized as a carrier for synthesis of etodolac-dextra", "tokenized_content": [2, 15195, 3, 3996, 14501, 1930, 2246, 9899, 2838, 18, 43, 23417, 4593, 15195, 2258, 2252, 7079, 1966, 43, 9685, 1958, 4271, 1927, 2140, 1986, 10173, 1030, 17, 20256, 5524, 3]}, "items": [{"id": "p_4684", "content": "Dextrans [SEP] A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagu", "score": 1, "type": null, "tokenized_content": [2, 15195, 1036, 3, 43, 2210, 1927, 3817, 11039, 3915, 2007, 4908, 4802, 18, 15195, 1036, 2032, 2251, 25058, 1966, 3582, 3776, 7305, 2045, 1930, 11693, 2006, 1032, 3]}]}
{"query": {"id": "q_4685", "content": "etodolac [SEP] polymer dextran has been utilized as a carrier for synthesis of etodolac-dextran conjugates (ED) to improve its aqueous solubility and r", "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 4593, 15195, 2258, 2252, 7079, 1966, 43, 9685, 1958, 4271, 1927, 2140, 1986, 10173, 1030, 17, 15195, 14749, 12, 3347, 13, 1942, 3326, 2496, 8052, 3]}, "items": [{"id": "p_4685", "content": "Etodolac [SEP] A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in ", "score": 1, "type": null, "tokenized_content": [2, 2140, 1986, 10173, 1030, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 6828, 14501, 1930, 2246, 18956, 7635, 3879, 18, 2176, 2258, 2252, 2522, 1942, 1998, 3655, 1922, 3]}]}
{"query": {"id": "q_4686", "content": "acetic acid [SEP] nalgesic and antiinflammatory activities were ascertained using acetic acid induced writhing model (mice) and carrageenan-induced rat paw e", "tokenized_content": [2, 13069, 2687, 3, 13120, 2286, 1935, 1930, 2246, 9899, 4209, 1985, 19231, 2193, 13069, 2687, 2719, 4573, 1953, 1941, 2322, 12, 2518, 13, 1930, 30486, 17, 2719, 3067, 15329, 47, 3]}, "items": [{"id": "p_4686", "content": "Acetic Acid [SEP] Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as", "score": 1, "type": null, "tokenized_content": [2, 13069, 2687, 3, 4863, 1927, 1920, 6638, 1927, 5757, 1930, 1927, 1920, 21243, 3653, 10888, 1929, 1927, 10211, 18, 2176, 1977, 2251, 10753, 16, 14647, 23125, 16, 1966, 3]}]}
{"query": {"id": "q_4687", "content": "writhing [SEP] lammatory activities were ascertained using acetic acid induced writhing model (mice) and carrageenan-induced rat paw edema model, respe", "tokenized_content": [2, 4573, 1953, 1941, 3, 8282, 3368, 27708, 4209, 1985, 19231, 2193, 13069, 2687, 2719, 4573, 1953, 1941, 2322, 12, 2518, 13, 1930, 30486, 17, 2719, 3067, 15329, 10144, 2322, 16, 3]}, "items": [{"id": "p_4687", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4688", "content": "carrageenan [SEP] ascertained using acetic acid induced writhing model (mice) and carrageenan-induced rat paw edema model, respectively. In comparison to con", "tokenized_content": [2, 30486, 3, 19231, 2193, 13069, 2687, 2719, 4573, 1953, 1941, 2322, 12, 2518, 13, 1930, 30486, 17, 2719, 3067, 15329, 10144, 2322, 16, 2763, 18, 1922, 3723, 1942, 1962, 3]}, "items": [{"id": "p_4688", "content": "Carrageenan [SEP] A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS", "score": 1, "type": null, "tokenized_content": [2, 30486, 3, 43, 3224, 17, 6622, 5869, 2320, 5515, 1927, 26649, 18686, 2037, 2312, 17721, 18, 18095, 5777, 2032, 1920, 17187, 1023, 18901, 9136, 3176, 1036, 9635, 1034, 1957, 3]}]}
{"query": {"id": "q_4689", "content": "edema [SEP] d induced writhing model (mice) and carrageenan-induced rat paw edema model, respectively. In comparison to control, E and ED1-ED4 sh", "tokenized_content": [2, 10144, 3, 46, 2719, 4573, 1953, 1941, 2322, 12, 2518, 13, 1930, 30486, 17, 2719, 3067, 15329, 10144, 2322, 16, 2763, 18, 1922, 3723, 1942, 2285, 16, 47, 1930, 3347, 3]}, "items": [{"id": "p_4689", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_4690", "content": "Hypersensitivity [SEP] Hypersensitivity myocarditis complicating hypertrophic cardiomyopathy heart.", "tokenized_content": [2, 14625, 3, 14625, 27169, 6581, 6102, 2104, 17437, 14141, 4003, 18, 3]}, "items": [{"id": "p_4690", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_4691", "content": "myocarditis [SEP] Hypersensitivity myocarditis complicating hypertrophic cardiomyopathy heart.", "tokenized_content": [2, 27169, 3, 14625, 27169, 6581, 6102, 2104, 17437, 14141, 4003, 18, 3]}, "items": [{"id": "p_4691", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_4692", "content": "hypertrophic cardiomyopathy [SEP] Hypersensitivity myocarditis complicating hypertrophic cardiomyopathy heart.", "tokenized_content": [2, 17437, 14141, 3, 14625, 27169, 6581, 6102, 2104, 17437, 14141, 4003, 18, 3]}, "items": [{"id": "p_4692", "content": "Cardiomyopathy, Hypertrophic [SEP] A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYP", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 17437, 3, 43, 2386, 1927, 4435, 3760, 2573, 16, 4378, 2007, 3506, 1930, 19, 2014, 3659, 6493, 11014, 12, 11014, 16, 3506, 6493, 31, 2483, 3]}]}
{"query": {"id": "q_4693", "content": "eosinophilic [SEP] The present report describes a case of eosinophilic myocarditis complicating hypertrophic cardiomyopathy. The 47-ye", "tokenized_content": [2, 21254, 3, 1920, 2481, 3809, 9845, 43, 3087, 1927, 21254, 27169, 6581, 6102, 2104, 17437, 14141, 18, 1920, 4261, 17, 5293, 3]}, "items": [{"id": "p_4693", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_4694", "content": "myocarditis [SEP] The present report describes a case of eosinophilic myocarditis complicating hypertrophic cardiomyopathy. The 47-year-old femal", "tokenized_content": [2, 27169, 3, 1920, 2481, 3809, 9845, 43, 3087, 1927, 21254, 27169, 6581, 6102, 2104, 17437, 14141, 18, 1920, 4261, 17, 2476, 17, 4156, 3210, 1923, 3]}, "items": [{"id": "p_4694", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_4695", "content": "hypertrophic cardiomyopathy [SEP] eport describes a case of eosinophilic myocarditis complicating hypertrophic cardiomyopathy. The 47-year-old female patient, known to have hypertrophic car", "tokenized_content": [2, 17437, 14141, 3, 15751, 7446, 9845, 43, 3087, 1927, 21254, 27169, 6581, 6102, 2104, 17437, 14141, 18, 1920, 4261, 17, 2476, 17, 4156, 4232, 2774, 16, 3171, 1942, 2162, 17437, 3]}, "items": [{"id": "p_4695", "content": "Cardiomyopathy, Hypertrophic [SEP] A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYP", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 17437, 3, 43, 2386, 1927, 4435, 3760, 2573, 16, 4378, 2007, 3506, 1930, 19, 2014, 3659, 6493, 11014, 12, 11014, 16, 3506, 6493, 31, 2483, 3]}]}
{"query": {"id": "q_4696", "content": "biventricular failure [SEP] t, known to have hypertrophic cardiomyopathy, was admitted with biventricular failure and managed aggressively with dobutamine infusion and other dru", "tokenized_content": [2, 27535, 11817, 4574, 3, 62, 16, 3171, 1942, 2162, 17437, 14141, 16, 1982, 9723, 1956, 27535, 11817, 4574, 1930, 11155, 8704, 1954, 1956, 2608, 16119, 3812, 7386, 1930, 2303, 2324, 3]}, "items": [{"id": "p_4696", "content": "Ventricular Dysfunction [SEP] A condition in which HEART VENTRICLES exhibit impaired function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 3, 43, 2625, 1922, 2154, 4003, 21008, 5987, 5761, 2347, 18, 3]}]}
{"query": {"id": "q_4697", "content": "dobutamine [SEP] mitted with biventricular failure and managed aggressively with dobutamine infusion and other drugs while being assessed for heart transpl", "tokenized_content": [2, 2608, 16119, 3812, 3, 3263, 2013, 1956, 27535, 11817, 4574, 1930, 11155, 8704, 1954, 1956, 2608, 16119, 3812, 7386, 1930, 2303, 4195, 2679, 3301, 3683, 1958, 4003, 9729, 3]}, "items": [{"id": "p_4697", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_4698", "content": "left ventricular dysfunction [SEP] nsplantation. On transthoracic echocardiogram, she had moderate left ventricular dysfunction with regional variability and moderate mitral regurgitation. Th", "tokenized_content": [2, 3506, 6493, 5273, 3, 16672, 17576, 4926, 18, 1990, 28541, 30095, 16, 4693, 2430, 5086, 3506, 6493, 5273, 1956, 6937, 5687, 1930, 5086, 13868, 20198, 18, 1913, 3]}, "items": [{"id": "p_4698", "content": "Ventricular Dysfunction, Left [SEP] A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; M", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 16, 3506, 3, 43, 2625, 1922, 2154, 1920, 3506, 11887, 1927, 1920, 4003, 1982, 9346, 5761, 18, 2052, 2625, 5394, 5029, 1942, 4003, 4574, 31, 55, 3]}]}
{"query": {"id": "q_4699", "content": "mitral regurgitation [SEP]  ventricular dysfunction with regional variability and moderate mitral regurgitation. The recipient's heart showed the features of apical hypertroph", "tokenized_content": [2, 13868, 20198, 3, 6493, 5273, 1956, 6937, 5687, 1930, 5086, 13868, 20198, 18, 1920, 10664, 11, 61, 4003, 2594, 1920, 4075, 1927, 8913, 4506, 2789, 3]}, "items": [{"id": "p_4699", "content": "Mitral Valve Insufficiency [SEP] Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mi", "score": 1, "type": null, "tokenized_content": [2, 13868, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3506, 11887, 2460, 1920, 3506, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 13868, 9509, 18, 2052, 2112, 2949, 1942, 6519, 3]}]}
{"query": {"id": "q_4700", "content": "Myocarditis [SEP] ophic cardiomyopathy and myocarditis with abundant eosinophils. Myocarditis is rare and eosinophilic myocarditis is rarer. It is likely tha", "tokenized_content": [2, 27169, 3, 11409, 1935, 14141, 1930, 27169, 1956, 7437, 15854, 18, 27169, 1977, 5844, 1930, 21254, 27169, 1977, 5844, 1005, 18, 2176, 1977, 3205, 21513, 3]}, "items": [{"id": "p_4700", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_4701", "content": "hypersensitivity [SEP] re and eosinophilic myocarditis is rarer. It is likely that the hypersensitivity (eosinophilic) myocarditis was related to dobutamine infusion t", "tokenized_content": [2, 14625, 3, 1964, 1930, 21254, 27169, 1977, 5844, 1005, 18, 2176, 1977, 3205, 1988, 1920, 14625, 12, 21254, 13, 27169, 1982, 2712, 1942, 2608, 16119, 3812, 7386, 62, 3]}, "items": [{"id": "p_4701", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_4702", "content": "Eosinophilic [SEP] philic) myocarditis was related to dobutamine infusion therapy. Eosinophilic myocarditis has been reported with an incidence of 2.4% to 7.2%", "tokenized_content": [2, 21254, 3, 10894, 1935, 13, 27169, 1982, 2712, 1942, 2608, 16119, 3812, 7386, 3181, 18, 21254, 27169, 2258, 2252, 2568, 1956, 1925, 4332, 1927, 22, 18, 24, 9, 1942, 27, 3]}, "items": [{"id": "p_4702", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_4703", "content": "All- trans-retinoic acid [SEP] All- trans-retinoic acid-induced erythema nodosum in patients with acute promyelocytic l", "tokenized_content": [2, 2136, 17, 2127, 17, 18014, 2687, 3, 2136, 17, 2127, 17, 18014, 2687, 17, 2719, 23349, 3889, 14740, 1922, 2132, 1956, 3939, 2720, 12592, 8316, 54, 3]}, "items": [{"id": "p_4703", "content": "Tretinoin [SEP] An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic aci", "score": 1, "type": null, "tokenized_content": [2, 2171, 2268, 9024, 3, 1925, 2715, 7888, 1927, 2359, 2294, 2409, 2905, 1930, 2740, 16, 1930, 1922, 15347, 18, 2171, 2268, 9024, 16, 2222, 3171, 1966, 18014, 2000, 1033, 3]}]}
{"query": {"id": "q_4704", "content": "erythema nodosum [SEP] All- trans-retinoic acid-induced erythema nodosum in patients with acute promyelocytic leukemia.", "tokenized_content": [2, 23349, 3889, 14740, 3, 2136, 17, 2127, 17, 18014, 2687, 17, 2719, 23349, 3889, 14740, 1922, 2132, 1956, 3939, 2720, 12592, 8316, 8111, 18, 3]}, "items": [{"id": "p_4704", "content": "Erythema Nodosum [SEP] An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are", "score": 1, "type": null, "tokenized_content": [2, 23349, 3889, 14740, 3, 1925, 19216, 2080, 25655, 5384, 2458, 1956, 2838, 5298, 2014, 2909, 1930, 4378, 2007, 3769, 12128, 1988, 2032, 3]}]}
{"query": {"id": "q_4705", "content": "acute promyelocytic leukemia [SEP] - trans-retinoic acid-induced erythema nodosum in patients with acute promyelocytic leukemia.", "tokenized_content": [2, 3939, 2720, 12592, 8316, 8111, 3, 17, 2127, 17, 18014, 2687, 17, 2719, 23349, 3889, 14740, 1922, 2132, 1956, 3939, 2720, 12592, 8316, 8111, 18, 3]}, "items": [{"id": "p_4705", "content": "Leukemia, Promyelocytic, Acute [SEP] An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCUL", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 2720, 12592, 8316, 16, 3939, 3, 1925, 3939, 9677, 8111, 1922, 2154, 4552, 2720, 12592, 3443, 5642, 5661, 18, 2176, 1977, 5467, 2458, 1956, 17593, 6306, 9361, 3]}]}
{"query": {"id": "q_4706", "content": "Erythema nodosum [SEP] Erythema nodosum associated with all- trans-retinoic acid (ATRA) for acute promy", "tokenized_content": [2, 23349, 3889, 14740, 3, 23349, 3889, 14740, 2458, 1956, 2136, 17, 2127, 17, 18014, 2687, 12, 20319, 13, 1958, 3939, 2720, 1012, 3]}, "items": [{"id": "p_4706", "content": "Erythema Nodosum [SEP] An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are", "score": 1, "type": null, "tokenized_content": [2, 23349, 3889, 14740, 3, 1925, 19216, 2080, 25655, 5384, 2458, 1956, 2838, 5298, 2014, 2909, 1930, 4378, 2007, 3769, 12128, 1988, 2032, 3]}]}
{"query": {"id": "q_4707", "content": "all- trans-retinoic acid [SEP] Erythema nodosum associated with all- trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We ", "tokenized_content": [2, 2136, 17, 2127, 17, 18014, 2687, 3, 23349, 3889, 14740, 2458, 1956, 2136, 17, 2127, 17, 18014, 2687, 12, 20319, 13, 1958, 3939, 2720, 12592, 8316, 8111, 12, 18373, 13, 3]}, "items": [{"id": "p_4707", "content": "Tretinoin [SEP] An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic aci", "score": 1, "type": null, "tokenized_content": [2, 2171, 2268, 9024, 3, 1925, 2715, 7888, 1927, 2359, 2294, 2409, 2905, 1930, 2740, 16, 1930, 1922, 15347, 18, 2171, 2268, 9024, 16, 2222, 3171, 1966, 18014, 2000, 1033, 3]}]}
{"query": {"id": "q_4708", "content": "ATRA [SEP] Erythema nodosum associated with all- trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We descri", "tokenized_content": [2, 20319, 3, 23349, 3889, 14740, 2458, 1956, 2136, 17, 2127, 17, 18014, 2687, 12, 20319, 13, 1958, 3939, 2720, 12592, 8316, 8111, 12, 18373, 13, 1977, 3345, 5844, 18, 2038, 3]}, "items": [{"id": "p_4708", "content": "Tretinoin [SEP] An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic aci", "score": 1, "type": null, "tokenized_content": [2, 2171, 2268, 9024, 3, 1925, 2715, 7888, 1927, 2359, 2294, 2409, 2905, 1930, 2740, 16, 1930, 1922, 15347, 18, 2171, 2268, 9024, 16, 2222, 3171, 1966, 18014, 2000, 1033, 3]}]}
{"query": {"id": "q_4709", "content": "acute promyelocytic leukemia [SEP] ema nodosum associated with all- trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We describe four patients with classic APL ", "tokenized_content": [2, 3939, 2720, 12592, 8316, 8111, 3, 23444, 3889, 14740, 2458, 1956, 2136, 17, 2127, 17, 18014, 2687, 12, 20319, 13, 1958, 3939, 2720, 12592, 8316, 8111, 12, 18373, 13, 1977, 3]}, "items": [{"id": "p_4709", "content": "Leukemia, Promyelocytic, Acute [SEP] An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCUL", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 2720, 12592, 8316, 16, 3939, 3, 1925, 3939, 9677, 8111, 1922, 2154, 4552, 2720, 12592, 3443, 5642, 5661, 18, 2176, 1977, 5467, 2458, 1956, 17593, 6306, 9361, 3]}]}
{"query": {"id": "q_4710", "content": "APL [SEP] l- trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We describe four patients with classic APL who d", "tokenized_content": [2, 18373, 3, 54, 17, 2127, 17, 18014, 2687, 12, 20319, 13, 1958, 3939, 2720, 12592, 8316, 8111, 12, 18373, 13, 1977, 3345, 5844, 18, 2038, 5993, 3006, 2132, 1956, 12211, 3]}, "items": [{"id": "p_4710", "content": "Leukemia, Promyelocytic, Acute [SEP] An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCUL", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 2720, 12592, 8316, 16, 3939, 3, 1925, 3939, 9677, 8111, 1922, 2154, 4552, 2720, 12592, 3443, 5642, 5661, 18, 2176, 1977, 5467, 2458, 1956, 17593, 6306, 9361, 3]}]}
{"query": {"id": "q_4711", "content": "erythema nodosum [SEP]  rare. We describe four patients with classic APL who developed erythema nodosum during ATRA therapy. Fever and subsequent multiple painful eryt", "tokenized_content": [2, 23349, 3889, 14740, 3, 5844, 18, 2038, 5993, 3006, 2132, 1956, 12211, 18373, 2746, 3530, 23349, 3889, 14740, 2409, 20319, 3181, 18, 9087, 1930, 4521, 3137, 15806, 2668, 2355, 3]}, "items": [{"id": "p_4711", "content": "Erythema Nodosum [SEP] An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are", "score": 1, "type": null, "tokenized_content": [2, 23349, 3889, 14740, 3, 1925, 19216, 2080, 25655, 5384, 2458, 1956, 2838, 5298, 2014, 2909, 1930, 4378, 2007, 3769, 12128, 1988, 2032, 3]}]}
{"query": {"id": "q_4712", "content": "Fever [SEP] classic APL who developed erythema nodosum during ATRA therapy. Fever and subsequent multiple painful erythematous nodules over extre", "tokenized_content": [2, 9087, 3, 12211, 18373, 2746, 3530, 23349, 3889, 14740, 2409, 20319, 3181, 18, 9087, 1930, 4521, 3137, 15806, 19216, 2080, 12128, 2338, 5528, 3]}, "items": [{"id": "p_4712", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_4713", "content": "painful [SEP] hema nodosum during ATRA therapy. Fever and subsequent multiple painful erythematous nodules over extremities developed on D11, D16, D1", "tokenized_content": [2, 15806, 3, 3243, 1019, 3889, 14740, 2409, 20319, 3181, 18, 9087, 1930, 4521, 3137, 15806, 19216, 2080, 12128, 2338, 18884, 3530, 1990, 8524, 1009, 16, 8524, 1016, 16, 8524, 3]}, "items": [{"id": "p_4713", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4714", "content": "erythematous nodules [SEP] osum during ATRA therapy. Fever and subsequent multiple painful erythematous nodules over extremities developed on D11, D16, D17, and D19, respectiv", "tokenized_content": [2, 19216, 2080, 12128, 3, 3125, 1989, 2409, 20319, 3181, 18, 9087, 1930, 4521, 3137, 15806, 19216, 2080, 12128, 2338, 18884, 3530, 1990, 8524, 1009, 16, 8524, 1016, 16, 8524, 1027, 3]}, "items": [{"id": "p_4714", "content": "Erythema Nodosum [SEP] An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are", "score": 1, "type": null, "tokenized_content": [2, 23349, 3889, 14740, 3, 1925, 19216, 2080, 25655, 5384, 2458, 1956, 2838, 5298, 2014, 2909, 1930, 4378, 2007, 3769, 12128, 1988, 2032, 3]}]}
{"query": {"id": "q_4715", "content": "steroids [SEP] nt with erythema nodosum. All patients received short course of steroids. Fever subsided rapidly and the skin lesions regressed complete", "tokenized_content": [2, 13039, 3, 5891, 1956, 23349, 3889, 14740, 18, 2136, 2132, 4004, 3662, 4914, 1927, 13039, 18, 9087, 23981, 1919, 6221, 1930, 1920, 4407, 4518, 26832, 4080, 3]}, "items": [{"id": "p_4715", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4716", "content": "steroid [SEP] nt with erythema nodosum. All patients received short course of steroids. Fever subsided rapidly and the skin lesions regressed complet", "tokenized_content": [2, 9507, 3, 5891, 1956, 23349, 3889, 14740, 18, 2136, 2132, 4004, 3662, 4914, 1927, 13039, 18, 9087, 23981, 1919, 6221, 1930, 1920, 4407, 4518, 26832, 3155, 3]}, "items": [{"id": "p_4716", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4717", "content": "heparin [SEP] Delayed-onset heparin-induced thrombocytopenia.", "tokenized_content": [2, 9962, 3, 7083, 17, 4727, 9962, 17, 2719, 17100, 18, 3]}, "items": [{"id": "p_4717", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4718", "content": "thrombocytopenia [SEP] Delayed-onset heparin-induced thrombocytopenia.", "tokenized_content": [2, 17100, 3, 7083, 17, 4727, 9962, 17, 2719, 17100, 18, 3]}, "items": [{"id": "p_4718", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_4719", "content": "Heparin [SEP] BACKGROUND: Heparin-induced thrombocytopenia presents 5 to 12 days after heparin ex", "tokenized_content": [2, 9962, 3, 3872, 30, 9962, 17, 2719, 17100, 8178, 25, 1942, 2369, 3000, 2256, 9962, 1975, 3]}, "items": [{"id": "p_4719", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4720", "content": "thrombocytopenia [SEP] BACKGROUND: Heparin-induced thrombocytopenia presents 5 to 12 days after heparin exposure, with or without a", "tokenized_content": [2, 17100, 3, 3872, 30, 9962, 17, 2719, 17100, 8178, 25, 1942, 2369, 3000, 2256, 9962, 3395, 16, 1956, 2014, 2979, 43, 3]}, "items": [{"id": "p_4720", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_4721", "content": "heparin [SEP] D: Heparin-induced thrombocytopenia presents 5 to 12 days after heparin exposure, with or without arterial or venous thromboemboli. Del", "tokenized_content": [2, 9962, 3, 46, 30, 9962, 17, 2719, 17100, 8178, 25, 1942, 2369, 3000, 2256, 9962, 3395, 16, 1956, 2014, 2979, 6624, 2014, 8562, 17361, 8436, 18, 2723, 3]}, "items": [{"id": "p_4721", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4722", "content": "venous thromboemboli [SEP]  to 12 days after heparin exposure, with or without arterial or venous thromboemboli. Delayed recognition and treatment of heparin-induced thrombocy", "tokenized_content": [2, 8562, 17361, 8436, 3, 1942, 2369, 3000, 2256, 9962, 3395, 16, 1956, 2014, 2979, 6624, 2014, 8562, 17361, 8436, 18, 7083, 5708, 1930, 2311, 1927, 9962, 17, 2719, 16379, 13796, 3]}, "items": [{"id": "p_4722", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_4723", "content": "thromboembolic [SEP] d thrombocytopenia became apparent on delayed presentation with thromboembolic complications. MEASUREMENTS: Platelet counts, onset of objectiv", "tokenized_content": [2, 25580, 3, 46, 17100, 7935, 6273, 1990, 7083, 6544, 1956, 25580, 5021, 18, 4146, 30, 7163, 6965, 16, 4727, 1927, 8032, 2068, 3]}, "items": [{"id": "p_4723", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_4724", "content": "thromboembolism [SEP]  MEASUREMENTS: Platelet counts, onset of objectively determined thromboembolism, results of heparin-induced platelet factor 4 antibody tests, a", "tokenized_content": [2, 23821, 3, 4146, 30, 7163, 6965, 16, 4727, 1927, 21287, 3180, 23821, 16, 2274, 1927, 9962, 17, 2719, 7163, 2991, 24, 3533, 4026, 16, 43, 3]}, "items": [{"id": "p_4724", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_4725", "content": "Thromboemboli [SEP] he hospital (median, day 14) with thromboembolic complications. Thromboemboli were venous (12 patients, 7 with pulmonary emboli) or arterial ", "tokenized_content": [2, 17361, 8436, 3, 2234, 3461, 12, 4181, 16, 3007, 2607, 13, 1956, 25580, 5021, 18, 17361, 8436, 1985, 8562, 12, 2369, 2132, 16, 27, 1956, 5352, 12494, 1033, 13, 2014, 3]}, "items": [{"id": "p_4725", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_4726", "content": "pulmonary emboli [SEP] c complications. Thromboemboli were venous (12 patients, 7 with pulmonary emboli) or arterial (4 patients) or both. Platelet counts were mildly ", "tokenized_content": [2, 5352, 12494, 1033, 3, 45, 5021, 18, 17361, 8436, 1985, 8562, 12, 2369, 2132, 16, 27, 1956, 5352, 12494, 1033, 13, 2014, 6624, 12, 24, 2132, 13, 2014, 2321, 18, 3]}, "items": [{"id": "p_4726", "content": "Pulmonary Embolism [SEP] Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5352, 19287, 3, 7472, 1927, 1920, 5352, 5511, 2014, 2340, 1927, 2496, 11208, 2007, 1925, 12494, 1957, 18, 3]}]}
{"query": {"id": "q_4727", "content": "warfarin [SEP] ents), inferior vena cava filters (3 patients) and, eventually, warfarin (11 patients). Three patients died. CONCLUSIONS: Delayed-onset ", "tokenized_content": [2, 16170, 3, 8496, 1036, 13, 16, 8756, 22876, 23326, 11732, 12, 23, 2132, 13, 1930, 16, 10042, 16, 16170, 12, 2513, 2132, 13, 18, 2559, 2132, 8545, 18, 4355, 30, 3]}, "items": [{"id": "p_4727", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_4728", "content": "Valsartan [SEP] Valsartan, a new angiotensin II antagonist for the treatment of essential", "tokenized_content": [2, 2326, 5735, 7446, 1928, 3, 2326, 5735, 7446, 1928, 16, 43, 2814, 10814, 2890, 8151, 1958, 1920, 2311, 1927, 4415, 3]}, "items": [{"id": "p_4728", "content": "valsartan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2326, 5735, 7446, 1928, 3, 3]}]}
{"query": {"id": "q_4729", "content": "angiotensin II [SEP] Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: a compa", "tokenized_content": [2, 10814, 2890, 3, 2326, 5735, 7446, 1928, 16, 43, 2814, 10814, 2890, 8151, 1958, 1920, 2311, 1927, 4415, 5579, 30, 43, 2059, 1019, 3]}, "items": [{"id": "p_4729", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_4730", "content": "hypertension [SEP]  a new angiotensin II antagonist for the treatment of essential hypertension: a comparative study of the efficacy and safety against amlodip", "tokenized_content": [2, 5579, 3, 43, 2814, 10814, 2890, 8151, 1958, 1920, 2311, 1927, 4415, 5579, 30, 43, 8255, 2161, 1927, 1920, 4348, 1930, 5407, 3316, 9508, 15799, 1034, 3]}, "items": [{"id": "p_4730", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4731", "content": "amlodipine [SEP] tension: a comparative study of the efficacy and safety against amlodipine.", "tokenized_content": [2, 9508, 26584, 3, 10146, 30, 43, 8255, 2161, 1927, 1920, 4348, 1930, 5407, 3316, 9508, 26584, 18, 3]}, "items": [{"id": "p_4731", "content": "Amlodipine [SEP] A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.\n   ", "score": 1, "type": null, "tokenized_content": [2, 9508, 26584, 3, 43, 2815, 17, 8290, 11842, 18425, 5802, 5016, 4999, 14580, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 1930, 5579, 18, 3]}]}
{"query": {"id": "q_4732", "content": "angiotensin II [SEP] OBJECTIVE: To compare the antihypertensive efficacy of a new angiotensin II antagonist, valsartan, with a reference therapy, amlodipine. ME", "tokenized_content": [2, 10814, 2890, 3, 4470, 30, 1942, 5175, 1920, 16439, 4348, 1927, 43, 2814, 10814, 2890, 8151, 16, 2326, 5735, 7446, 1928, 16, 1956, 43, 4386, 3181, 16, 9508, 26584, 18, 3]}, "items": [{"id": "p_4732", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_4733", "content": "valsartan [SEP] e antihypertensive efficacy of a new angiotensin II antagonist, valsartan, with a reference therapy, amlodipine. METHODS: One hundred six", "tokenized_content": [2, 2326, 5735, 7446, 1928, 3, 47, 16439, 4348, 1927, 43, 2814, 10814, 2890, 8151, 16, 2326, 5735, 7446, 1928, 16, 1956, 43, 4386, 3181, 16, 9508, 26584, 18, 2860, 30, 3]}, "items": [{"id": "p_4733", "content": "valsartan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2326, 5735, 7446, 1928, 3, 3]}]}
{"query": {"id": "q_4734", "content": "amlodipine [SEP] angiotensin II antagonist, valsartan, with a reference therapy, amlodipine. METHODS: One hundred sixty-eight adult outpatients with mild t", "tokenized_content": [2, 9508, 26584, 3, 10814, 2890, 8151, 16, 2326, 5735, 7446, 1928, 16, 1956, 43, 4386, 3181, 16, 9508, 26584, 18, 2860, 30, 2340, 8295, 14063, 17, 5066, 4160, 20204, 1956, 3]}, "items": [{"id": "p_4734", "content": "Amlodipine [SEP] A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.\n   ", "score": 1, "type": null, "tokenized_content": [2, 9508, 26584, 3, 43, 2815, 17, 8290, 11842, 18425, 5802, 5016, 4999, 14580, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 1930, 5579, 18, 3]}]}
{"query": {"id": "q_4735", "content": "hypertension [SEP] One hundred sixty-eight adult outpatients with mild to moderate hypertension were randomly allocated in double-blind fashion and equal numbe", "tokenized_content": [2, 5579, 3, 2340, 8295, 14063, 17, 5066, 4160, 20204, 1956, 5809, 1942, 5086, 5579, 1985, 6266, 14553, 1922, 4825, 17, 7109, 10251, 1930, 5557, 25646, 1021, 3]}, "items": [{"id": "p_4735", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4736", "content": "edema [SEP] ts were well tolerated. The incidence of drug-related dependent edema was somewhat higher in the amlodipine group, particularly at a ", "tokenized_content": [2, 10144, 3, 4894, 1985, 2486, 11117, 18, 1920, 4332, 1927, 2838, 17, 2712, 3100, 10144, 1982, 9786, 2580, 1922, 1920, 9508, 26584, 2210, 16, 4443, 2019, 43, 3]}, "items": [{"id": "p_4736", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_4737", "content": "dihydropyridine [SEP] ated with side effects characteristic of this comparator class, dihydropyridine calcium antagonists.", "tokenized_content": [2, 11842, 18425, 5802, 3, 30280, 1007, 1956, 4159, 2564, 6293, 1927, 2052, 26096, 2921, 16, 11842, 18425, 5802, 5016, 10515, 18, 3]}, "items": [{"id": "p_4737", "content": "1,4-dihydropyridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 24, 17, 11842, 18425, 5802, 3, 3]}]}
{"query": {"id": "q_4738", "content": "calcium [SEP] ffects characteristic of this comparator class, dihydropyridine calcium antagonists.", "tokenized_content": [2, 5016, 3, 10735, 2284, 6293, 1927, 2052, 26096, 2921, 16, 11842, 18425, 5802, 5016, 10515, 18, 3]}, "items": [{"id": "p_4738", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_4739", "content": "KF17837 [SEP] KF17837: a novel selective adenosine A2A receptor antagonist with antic", "tokenized_content": [2, 21993, 24761, 5494, 3, 21993, 24761, 5494, 30, 43, 4008, 5328, 10125, 27045, 3148, 8151, 1956, 5851, 3]}, "items": [{"id": "p_4739", "content": "KF 17837 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21993, 16877, 5494, 3, 3]}]}
{"query": {"id": "q_4740", "content": "adenosine [SEP] KF17837: a novel selective adenosine A2A receptor antagonist with anticataleptic activity.", "tokenized_content": [2, 10125, 3, 21993, 24761, 5494, 30, 43, 4008, 5328, 10125, 27045, 3148, 8151, 1956, 5851, 4607, 17920, 2455, 18, 3]}, "items": [{"id": "p_4740", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_4741", "content": "KF17837 [SEP] KF17837 is a novel selective adenosine A2A receptor antagonist. Oral ad", "tokenized_content": [2, 21993, 24761, 5494, 3, 21993, 24761, 5494, 1977, 43, 4008, 5328, 10125, 27045, 3148, 8151, 18, 4726, 2041, 3]}, "items": [{"id": "p_4741", "content": "KF 17837 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21993, 16877, 5494, 3, 3]}]}
{"query": {"id": "q_4742", "content": "adenosine [SEP] KF17837 is a novel selective adenosine A2A receptor antagonist. Oral administration of KF17837 (2.5, 1", "tokenized_content": [2, 10125, 3, 21993, 24761, 5494, 1977, 43, 4008, 5328, 10125, 27045, 3148, 8151, 18, 4726, 4183, 1927, 21993, 24761, 5494, 12, 22, 18, 25, 16, 21, 3]}, "items": [{"id": "p_4742", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_4743", "content": "cataleptic [SEP] F17837 (2.5, 10.0 and 30.0 mg/kg) significantly ameliorated the cataleptic responses induced by intracerebroventricular administration of ", "tokenized_content": [2, 4233, 17920, 3, 9154, 7950, 5494, 12, 22, 18, 25, 16, 2119, 18, 20, 1930, 2627, 18, 20, 2786, 19, 3621, 13, 2567, 22085, 1920, 4233, 17920, 3387, 2719, 2007, 3]}, "items": [{"id": "p_4743", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4744", "content": "CGS 21680 [SEP] entricular administration of an adenosine A2A receptor agonist, CGS 21680 (10 micrograms), in a dose-dependent manner. KF17837 also reduc", "tokenized_content": [2, 7294, 1036, 17663, 4476, 3, 5695, 4588, 4183, 1927, 1925, 10125, 27045, 3148, 7829, 16, 7294, 1036, 17663, 4476, 12, 2119, 13362, 13, 16, 1922, 43, 3253, 17, 3100, 5222, 3]}, "items": [{"id": "p_4744", "content": "2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 12, 24, 17, 12, 22, 17, 15750, 5188, 13, 3037, 5188, 19143, 13, 17, 25, 11, 17, 56, 17, 7843, 15339, 18276, 25238, 8194, 19824, 6777, 1021, 3, 3]}]}
{"query": {"id": "q_4745", "content": "catalepsy [SEP] crograms), in a dose-dependent manner. KF17837 also reduced the catalepsy induced by haloperidol (1 mg/kg i.p.) and by reserpine (5 mg/kg", "tokenized_content": [2, 4233, 9431, 1012, 3, 9442, 28218, 13, 16, 1922, 43, 3253, 17, 3100, 5222, 18, 21993, 24761, 5494, 2222, 3028, 1920, 4233, 9431, 1012, 2719, 2007, 25107, 12, 21, 2786, 3]}, "items": [{"id": "p_4745", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4746", "content": "haloperidol [SEP] dependent manner. KF17837 also reduced the catalepsy induced by haloperidol (1 mg/kg i.p.) and by reserpine (5 mg/kg i.p.). These anticatal", "tokenized_content": [2, 25107, 3, 3100, 5222, 18, 21993, 24761, 5494, 2222, 3028, 1920, 4233, 9431, 1012, 2719, 2007, 25107, 12, 21, 2786, 19, 3621, 51, 18, 58, 18, 13, 1930, 2007, 1995, 3]}, "items": [{"id": "p_4746", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_4747", "content": "reserpine [SEP] uced the catalepsy induced by haloperidol (1 mg/kg i.p.) and by reserpine (5 mg/kg i.p.). These anticataleptic effects were exhibited dos", "tokenized_content": [2, 1995, 1915, 12184, 3, 8577, 1919, 1920, 4233, 9431, 1012, 2719, 2007, 25107, 12, 21, 2786, 19, 3621, 51, 18, 58, 18, 13, 1930, 2007, 1995, 1915, 12184, 12, 25, 3]}, "items": [{"id": "p_4747", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_4748", "content": "L-3,4-dihydroxyphenylalanine [SEP] otentiated the anticataleptic effects of a subthreshold dose of L-3,4-dihydroxyphenylalanine (L-DOPA; 25 mg/kg i.p.) plus benserazide (6.25 mg/kg i.p.). The", "tokenized_content": [2, 54, 17, 23, 16, 24, 17, 20684, 17616, 2199, 15769, 3, 7608, 7721, 2013, 1920, 5851, 4607, 17920, 2564, 1927, 43, 29862, 3253, 1927, 54, 17, 23, 16, 24, 17, 3]}, "items": [{"id": "p_4748", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4749", "content": "L-DOPA [SEP] effects of a subthreshold dose of L-3,4-dihydroxyphenylalanine (L-DOPA; 25 mg/kg i.p.) plus benserazide (6.25 mg/kg i.p.). These resul", "tokenized_content": [2, 54, 17, 19428, 3, 2564, 1927, 43, 29862, 3253, 1927, 54, 17, 23, 16, 24, 17, 20684, 17616, 2199, 15769, 12, 54, 17, 19428, 31, 2637, 2786, 19, 3621, 51, 3]}, "items": [{"id": "p_4749", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4750", "content": "benserazide [SEP] se of L-3,4-dihydroxyphenylalanine (L-DOPA; 25 mg/kg i.p.) plus benserazide (6.25 mg/kg i.p.). These results suggested that KF17837 is a ce", "tokenized_content": [2, 7129, 13545, 29895, 3, 2058, 1927, 54, 17, 23, 16, 24, 17, 20684, 17616, 2199, 15769, 12, 54, 17, 19428, 31, 2637, 2786, 19, 3621, 51, 18, 58, 18, 13, 3]}, "items": [{"id": "p_4750", "content": "Benserazide [SEP] An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatm", "score": 1, "type": null, "tokenized_content": [2, 7129, 13545, 29895, 3, 1925, 4106, 1927, 19428, 23922, 1988, 3731, 2084, 5553, 1920, 4101, 7580, 2433, 18, 2176, 1977, 3868, 3258, 1956, 26723, 1922, 1920, 2297, 1035, 3]}]}
{"query": {"id": "q_4751", "content": "parkinsonism [SEP] . Furthermore, KF17837 may be a useful drug in the treatment of parkinsonism.", "tokenized_content": [2, 26214, 3, 18, 3677, 16, 21993, 24761, 5494, 2278, 1998, 43, 4707, 2838, 1922, 1920, 2311, 1927, 26214, 18, 3]}, "items": [{"id": "p_4751", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_4752", "content": "fluvoxamine [SEP] Some central effects of repeated treatment with fluvoxamine.", "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 2673, 4101, 2564, 1927, 5116, 2311, 1956, 2848, 15525, 11414, 25157, 18, 3]}, "items": [{"id": "p_4752", "content": "Fluvoxamine [SEP] A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 43, 5328, 11153, 22957, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 1930, 43, 5386, 1927, 5592, 4414, 18, 3]}]}
{"query": {"id": "q_4753", "content": "fluvoxamine [SEP] We investigated the effect of repeated treatment with fluvoxamine, a selective serotonin uptake inhibitor, on behavioral effects ", "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 2038, 3845, 1920, 2495, 1927, 5116, 2311, 1956, 2848, 15525, 11414, 25157, 16, 43, 5328, 11153, 5047, 4106, 16, 1990, 5343, 2564, 3]}, "items": [{"id": "p_4753", "content": "Fluvoxamine [SEP] A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 15525, 11414, 25157, 3, 43, 5328, 11153, 22957, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 1930, 43, 5386, 1927, 5592, 4414, 18, 3]}]}
{"query": {"id": "q_4754", "content": "serotonin [SEP]  the effect of repeated treatment with fluvoxamine, a selective serotonin uptake inhibitor, on behavioral effects of dopaminomimetics and", "tokenized_content": [2, 11153, 3, 1920, 2495, 1927, 5116, 2311, 1956, 2848, 15525, 11414, 25157, 16, 43, 5328, 11153, 5047, 4106, 16, 1990, 5343, 2564, 1927, 19428, 8547, 1947, 21870, 1036, 1930, 3]}, "items": [{"id": "p_4754", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4755", "content": "methoxamine [SEP] uptake inhibitor, on behavioral effects of dopaminomimetics and methoxamine and on the animal behavior in the \"behavioral despair\" test. A ", "tokenized_content": [2, 24598, 3812, 3, 5047, 4106, 16, 1990, 5343, 2564, 1927, 19428, 8547, 1947, 21870, 1036, 1930, 24598, 3812, 1930, 1990, 1920, 4027, 3379, 1922, 1920, 6, 5343, 4268, 2675, 6, 3]}, "items": [{"id": "p_4755", "content": "Methoxamine [SEP] An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24598, 3812, 3, 1925, 4595, 17, 21, 13672, 7829, 1988, 5092, 7171, 5009, 21843, 18, 3]}]}
{"query": {"id": "q_4756", "content": "amphetamine [SEP] daily for 14 days) potentiated in mice and in rats (weaker) the amphetamine-induced hyperactivity. The hyperactivity induced by nomifensine", "tokenized_content": [2, 19057, 3, 4692, 1958, 2607, 3000, 13, 20419, 1922, 2518, 1930, 1922, 3615, 12, 12270, 13, 1920, 19057, 17, 2719, 15534, 18, 1920, 15534, 2719, 2007, 9684, 10528, 3355, 2053, 3]}, "items": [{"id": "p_4756", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_4757", "content": "hyperactivity [SEP] otentiated in mice and in rats (weaker) the amphetamine-induced hyperactivity. The hyperactivity induced by nomifensine in mice remained unaf", "tokenized_content": [2, 15534, 3, 7608, 7721, 2013, 1922, 2518, 1930, 1922, 3615, 12, 12270, 13, 1920, 19057, 17, 2719, 15534, 18, 1920, 15534, 2719, 2007, 9684, 10528, 3355, 2053, 1922, 2518, 5410, 3]}, "items": [{"id": "p_4757", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_4758", "content": "nomifensine [SEP] amphetamine-induced hyperactivity. The hyperactivity induced by nomifensine in mice remained unaffected by fluvoxamine. The stimulation of ", "tokenized_content": [2, 9684, 10528, 3355, 2053, 3, 19057, 17, 2719, 15534, 18, 1920, 15534, 2719, 2007, 9684, 10528, 3355, 2053, 1922, 2518, 5410, 10403, 2007, 2848, 15525, 11414, 25157, 18, 1920, 4177, 3]}, "items": [{"id": "p_4758", "content": "Nomifensine [SEP] An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of ", "score": 1, "type": null, "tokenized_content": [2, 9684, 10528, 3355, 2053, 3, 1925, 4911, 11072, 8419, 10533, 1988, 10299, 7964, 22957, 2460, 14009, 4686, 18, 1920, 4005, 2010, 1982, 22397, 2251, 1922, 1920, 2311, 1927, 3]}]}
{"query": {"id": "q_4759", "content": "citalopram [SEP] ndicate that fluvoxamine given repeatedly acts differently than citalopram, another selective serotonin uptake inhibitor, and differs also", "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 8026, 14494, 1988, 2848, 15525, 11414, 25157, 3258, 14959, 8016, 11874, 2254, 12366, 20807, 13399, 1035, 16, 3741, 5328, 11153, 5047, 4106, 16, 1930, 11457, 3]}, "items": [{"id": "p_4759", "content": "Citalopram [SEP] A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in redu", "score": 1, "type": null, "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 43, 28028, 15895, 6299, 12407, 1988, 1977, 2340, 1927, 1920, 11153, 5047, 4472, 2251, 1966, 1925, 14183, 18, 1920, 2838, 1977, 2222, 3655, 1922, 2312, 1032, 3]}]}
{"query": {"id": "q_4760", "content": "congestive heart failure [SEP] Severe congestive heart failure patient on amiodarone presenting with myxedemic coma: a case re", "tokenized_content": [2, 20180, 4003, 4574, 3, 4010, 20180, 4003, 4574, 2774, 1990, 15665, 25033, 2830, 1021, 8326, 1956, 21464, 1919, 4197, 22337, 30, 43, 3087, 1964, 3]}, "items": [{"id": "p_4760", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4761", "content": "amiodarone [SEP] Severe congestive heart failure patient on amiodarone presenting with myxedemic coma: a case report.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 4010, 20180, 4003, 4574, 2774, 1990, 15665, 25033, 2830, 1021, 8326, 1956, 21464, 1919, 4197, 22337, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4761", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_4762", "content": "myxedemic [SEP]  congestive heart failure patient on amiodarone presenting with myxedemic coma: a case report.", "tokenized_content": [2, 21464, 1919, 4197, 3, 20180, 4003, 4574, 2774, 1990, 15665, 25033, 2830, 1021, 8326, 1956, 21464, 1919, 4197, 22337, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4762", "content": "Myxedema [SEP] A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and ", "score": 1, "type": null, "tokenized_content": [2, 21464, 16670, 3, 43, 2625, 4378, 2007, 43, 7143, 16, 18578, 1012, 2601, 1927, 11438, 12, 10144, 13, 1956, 4552, 14371, 1927, 3422, 13580, 11926, 1922, 1920, 4407, 1930, 3]}]}
{"query": {"id": "q_4763", "content": "coma [SEP] e heart failure patient on amiodarone presenting with myxedemic coma: a case report.", "tokenized_content": [2, 22337, 3, 47, 4003, 4574, 2774, 1990, 15665, 25033, 2830, 1021, 8326, 1956, 21464, 1919, 4197, 22337, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4763", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_4764", "content": "myxedema [SEP] This is a case report of myxedema coma secondary to amiodarone-induced hypothyroidism in a patien", "tokenized_content": [2, 21464, 16670, 3, 2052, 1977, 43, 3087, 3809, 1927, 21464, 16670, 22337, 4067, 1942, 15665, 25033, 2830, 1021, 17, 2719, 19316, 1922, 43, 2091, 1917, 3]}, "items": [{"id": "p_4764", "content": "Myxedema [SEP] A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and ", "score": 1, "type": null, "tokenized_content": [2, 21464, 16670, 3, 43, 2625, 4378, 2007, 43, 7143, 16, 18578, 1012, 2601, 1927, 11438, 12, 10144, 13, 1956, 4552, 14371, 1927, 3422, 13580, 11926, 1922, 1920, 4407, 1930, 3]}]}
{"query": {"id": "q_4765", "content": "coma [SEP] This is a case report of myxedema coma secondary to amiodarone-induced hypothyroidism in a patient wit", "tokenized_content": [2, 22337, 3, 2052, 1977, 43, 3087, 3809, 1927, 21464, 16670, 22337, 4067, 1942, 15665, 25033, 2830, 1021, 17, 2719, 19316, 1922, 43, 2774, 16086, 3]}, "items": [{"id": "p_4765", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_4766", "content": "amiodarone [SEP] This is a case report of myxedema coma secondary to amiodarone-induced hypothyroidism in a patient with severe congestive hear", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 2052, 1977, 43, 3087, 3809, 1927, 21464, 16670, 22337, 4067, 1942, 15665, 25033, 2830, 1021, 17, 2719, 19316, 1922, 43, 2774, 1956, 4010, 20180, 3563, 3]}, "items": [{"id": "p_4766", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_4767", "content": "hypothyroidism [SEP]  a case report of myxedema coma secondary to amiodarone-induced hypothyroidism in a patient with severe congestive heart failure (CHF). To our", "tokenized_content": [2, 19316, 3, 43, 3087, 3809, 1927, 21464, 16670, 22337, 4067, 1942, 15665, 25033, 2830, 1021, 17, 2719, 19316, 1922, 43, 2774, 1956, 4010, 20180, 4003, 4574, 12, 18307, 13, 18, 3]}, "items": [{"id": "p_4767", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_4768", "content": "congestive heart failure [SEP] y to amiodarone-induced hypothyroidism in a patient with severe congestive heart failure (CHF). To our knowledge and after reviewing the literature ther", "tokenized_content": [2, 20180, 4003, 4574, 3, 67, 1942, 15665, 25033, 2830, 1021, 17, 2719, 19316, 1922, 43, 2774, 1956, 4010, 20180, 4003, 4574, 12, 18307, 13, 18, 1942, 2342, 4163, 1930, 2256, 3]}, "items": [{"id": "p_4768", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4769", "content": "CHF [SEP] pothyroidism in a patient with severe congestive heart failure (CHF). To our knowledge and after reviewing the literature there is ", "tokenized_content": [2, 18307, 3, 2543, 30338, 12245, 2421, 1922, 43, 2774, 1956, 4010, 20180, 4003, 4574, 12, 18307, 13, 18, 1942, 2342, 4163, 1930, 2256, 17036, 1920, 4431, 2276, 1977, 3]}, "items": [{"id": "p_4769", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4770", "content": "Myxedema [SEP] se report of myxedema coma during long term amiodarone therapy. Myxedema coma is a life threatening condition that carries a mortality r", "tokenized_content": [2, 21464, 16670, 3, 2058, 3809, 1927, 21464, 16670, 22337, 2409, 2815, 2576, 15665, 25033, 2830, 1021, 3181, 18, 21464, 16670, 22337, 1977, 43, 3308, 13281, 2625, 1988, 16252, 43, 3885, 3]}, "items": [{"id": "p_4770", "content": "Myxedema [SEP] A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and ", "score": 1, "type": null, "tokenized_content": [2, 21464, 16670, 3, 43, 2625, 4378, 2007, 43, 7143, 16, 18578, 1012, 2601, 1927, 11438, 12, 10144, 13, 1956, 4552, 14371, 1927, 3422, 13580, 11926, 1922, 1920, 4407, 1930, 3]}]}
{"query": {"id": "q_4771", "content": "thyroxine [SEP] s 20% with treatment. The condition is treated with intravenous thyroxine (T4) or intravenous tri-iodo-thyronine (T3). Patients with CHF ", "tokenized_content": [2, 29423, 3, 61, 2036, 9, 1956, 2311, 18, 1920, 2625, 1977, 2868, 1956, 7307, 29423, 12, 10773, 13, 2014, 7307, 5083, 17, 25469, 17, 16993, 8635, 2912, 12, 9627, 13, 3]}, "items": [{"id": "p_4771", "content": "Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an", "score": 1, "type": null, "tokenized_content": [2, 29423, 3, 1920, 3044, 6365, 3595, 2037, 1920, 6918, 8359, 18, 29423, 1977, 6653, 3454, 1920, 8594, 2636, 1927, 6941, 1036, 12, 8914, 13025, 26879, 13, 1925, 3]}]}
{"query": {"id": "q_4772", "content": "T4 [SEP] treatment. The condition is treated with intravenous thyroxine (T4) or intravenous tri-iodo-thyronine (T3). Patients with CHF on a", "tokenized_content": [2, 10773, 3, 2311, 18, 1920, 2625, 1977, 2868, 1956, 7307, 29423, 12, 10773, 13, 2014, 7307, 5083, 17, 25469, 17, 16993, 8635, 2912, 12, 9627, 13, 18, 2132, 1956, 18307, 3]}, "items": [{"id": "p_4772", "content": "Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an", "score": 1, "type": null, "tokenized_content": [2, 29423, 3, 1920, 3044, 6365, 3595, 2037, 1920, 6918, 8359, 18, 29423, 1977, 6653, 3454, 1920, 8594, 2636, 1927, 6941, 1036, 12, 8914, 13025, 26879, 13, 1925, 3]}]}
{"query": {"id": "q_4773", "content": "tri-iodo-thyronine [SEP] ition is treated with intravenous thyroxine (T4) or intravenous tri-iodo-thyronine (T3). Patients with CHF on amiodarone may suffer serious morbid", "tokenized_content": [2, 5083, 17, 25469, 17, 16993, 8635, 2912, 3, 2176, 2001, 1977, 2868, 1956, 7307, 29423, 12, 10773, 13, 2014, 7307, 5083, 17, 25469, 17, 16993, 8635, 2912, 12, 9627, 13, 3]}, "items": [{"id": "p_4773", "content": "Triiodothyronine [SEP] A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most", "score": 1, "type": null, "tokenized_content": [2, 5083, 13025, 27525, 11018, 2912, 3, 43, 9627, 6918, 6365, 7885, 6653, 1930, 8366, 2007, 1920, 6918, 8359, 1922, 4186, 5322, 12603, 2254, 29423, 12, 10773, 13, 18, 2501, 3]}]}
{"query": {"id": "q_4774", "content": "T3 [SEP] h intravenous thyroxine (T4) or intravenous tri-iodo-thyronine (T3). Patients with CHF on amiodarone may suffer serious morbidity ", "tokenized_content": [2, 9627, 3, 50, 7307, 29423, 12, 10773, 13, 2014, 7307, 5083, 17, 25469, 17, 16993, 8635, 2912, 12, 9627, 13, 18, 2132, 1956, 18307, 1990, 15665, 25033, 2830, 1021, 2278, 3]}, "items": [{"id": "p_4774", "content": "Triiodothyronine [SEP] A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most", "score": 1, "type": null, "tokenized_content": [2, 5083, 13025, 27525, 11018, 2912, 3, 43, 9627, 6918, 6365, 7885, 6653, 1930, 8366, 2007, 1920, 6918, 8359, 1922, 4186, 5322, 12603, 2254, 29423, 12, 10773, 13, 18, 2501, 3]}]}
{"query": {"id": "q_4775", "content": "hypotension [SEP] spect this clinical syndrome among CHF patients presenting with hypotension, weakness or other unexplained symptoms.", "tokenized_content": [2, 16453, 3, 4544, 2052, 2535, 4741, 2706, 18307, 2132, 8326, 1956, 16453, 16, 12175, 2014, 2303, 21109, 3601, 18, 3]}, "items": [{"id": "p_4775", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4776", "content": "weakness [SEP] inical syndrome among CHF patients presenting with hypotension, weakness or other unexplained symptoms.", "tokenized_content": [2, 12175, 3, 1922, 2046, 4741, 2706, 18307, 2132, 8326, 1956, 16453, 16, 12175, 2014, 2303, 21109, 3601, 18, 3]}, "items": [{"id": "p_4776", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_4777", "content": "startle [SEP] Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drug", "tokenized_content": [2, 21866, 3, 8196, 17, 20419, 21866, 16, 2308, 2084, 3696, 17, 4256, 21866, 16, 1977, 4256, 2007, 24400, 3880, 2838, 3]}, "items": [{"id": "p_4777", "content": "Reflex, Abnormal [SEP] An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased,", "score": 1, "type": null, "tokenized_content": [2, 11573, 16, 4552, 3, 1925, 4552, 2644, 1942, 43, 5794, 3730, 1942, 1920, 6893, 4178, 1927, 1920, 7580, 2433, 18, 2052, 2278, 6132, 1920, 2386, 1927, 2502, 16, 3]}]}
{"query": {"id": "q_4778", "content": "startle [SEP] RATIONALE AND OBJECTIVES: The light-enhanced startle paradigm (LES) is suggested to model anxiety, because of the no", "tokenized_content": [2, 21866, 3, 13202, 1930, 7634, 30, 1920, 3696, 17, 4256, 21866, 9930, 12, 3636, 13, 1977, 3978, 1942, 2322, 5592, 16, 2882, 1927, 1920, 2239, 3]}, "items": [{"id": "p_4778", "content": "Reflex, Abnormal [SEP] An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased,", "score": 1, "type": null, "tokenized_content": [2, 11573, 16, 4552, 3, 1925, 4552, 2644, 1942, 43, 5794, 3730, 1942, 1920, 6893, 4178, 1927, 1920, 7580, 2433, 18, 2052, 2278, 6132, 1920, 2386, 1927, 2502, 16, 3]}]}
{"query": {"id": "q_4779", "content": "anxiety [SEP] The light-enhanced startle paradigm (LES) is suggested to model anxiety, because of the non-specific cue and the long-term effect. In c", "tokenized_content": [2, 5592, 3, 1920, 3696, 17, 4256, 21866, 9930, 12, 3636, 13, 1977, 3978, 1942, 2322, 5592, 16, 2882, 1927, 1920, 2447, 17, 2487, 10200, 1930, 1920, 2815, 17, 2576, 2495, 3]}, "items": [{"id": "p_4779", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_4780", "content": "yohimbine [SEP] rats received each dose of the alpha(2)-adrenoceptor antagonist yohimbine (0.25-1.0mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpi", "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 3615, 4004, 2362, 3253, 1927, 1920, 4595, 12, 22, 13, 17, 25090, 8151, 7419, 7969, 17010, 2053, 12, 20, 18, 2637, 17, 21, 18, 20, 3]}, "items": [{"id": "p_4780", "content": "Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT", "score": 1, "type": null, "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 43, 4496, 29951, 1956, 4595, 17, 22, 17, 13672, 7472, 2455, 18, 7419, 7969, 17010, 2053, 2258, 2252, 2251, 1966, 43, 15388, 3027, 2479, 1930, 1922, 1920, 2311, 1927, 24311, 1031, 3]}]}
{"query": {"id": "q_4781", "content": "5-HT [SEP] alpha(2)-adrenoceptor antagonist yohimbine (0.25-1.0mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/", "tokenized_content": [2, 25, 17, 5334, 3, 4595, 12, 22, 13, 17, 25090, 8151, 7419, 7969, 17010, 2053, 12, 20, 18, 2637, 17, 21, 18, 20, 9759, 19, 3621, 13, 16, 1920, 25, 3]}, "items": [{"id": "p_4781", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4782", "content": "m-chlorophenylpiperazine [SEP] gonist yohimbine (0.25-1.0mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pe", "tokenized_content": [2, 55, 17, 10107, 17616, 2199, 10984, 2116, 10119, 3, 8239, 2184, 7419, 7969, 17010, 2053, 12, 20, 18, 2637, 17, 21, 18, 20, 9759, 19, 3621, 13, 16, 1920, 25, 3]}, "items": [{"id": "p_4782", "content": "1-(3-chlorophenyl)piperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 23, 17, 10107, 17616, 2199, 13, 16057, 10119, 3, 3]}]}
{"query": {"id": "q_4783", "content": "mCPP [SEP] mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pentylen", "tokenized_content": [2, 11942, 1034, 3, 2786, 19, 3621, 13, 16, 1920, 25, 17, 5334, 12, 6921, 13, 3148, 7829, 55, 17, 10107, 17616, 2199, 10984, 2116, 10119, 12, 11942, 1034, 16, 20, 3]}, "items": [{"id": "p_4783", "content": "1-(3-chlorophenyl)piperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 23, 17, 10107, 17616, 2199, 13, 16057, 10119, 3, 3]}]}
{"query": {"id": "q_4784", "content": "GABA [SEP] or agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pentylenetetrazole (PTZ, 3-30mg/kg)", "tokenized_content": [2, 7992, 3, 2014, 7829, 55, 17, 10107, 17616, 2199, 10984, 2116, 10119, 12, 11942, 1034, 16, 20, 18, 25, 17, 22, 18, 20, 9759, 19, 3621, 13, 2014, 1920, 7992, 3]}, "items": [{"id": "p_4784", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4785", "content": "pentylenetetrazole [SEP] ne (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pentylenetetrazole (PTZ, 3-30mg/kg) and were subsequently tested in either LES or ", "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 2069, 12, 11942, 1034, 16, 20, 18, 25, 17, 22, 18, 20, 9759, 19, 3621, 13, 2014, 1920, 7992, 12, 43, 13, 9526, 3]}, "items": [{"id": "p_4785", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_4786", "content": "PTZ [SEP] kg) or the GABA(A) inverse receptor agonist pentylenetetrazole (PTZ, 3-30mg/kg) and were subsequently tested in either LES or FPS. ", "tokenized_content": [2, 4401, 1011, 3, 3621, 13, 2014, 1920, 7992, 12, 43, 13, 9526, 3148, 7829, 9412, 6752, 14278, 21193, 13642, 1952, 12, 4401, 1011, 16, 23, 17, 2627, 9759, 19, 3621, 3]}, "items": [{"id": "p_4786", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_4787", "content": "glomerulonephritis [SEP] neutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment.", "tokenized_content": [2, 27057, 3, 9460, 6823, 3533, 17, 12, 2033, 1010, 17, 28573, 13, 2843, 27438, 27057, 2256, 27016, 7446, 1941, 13528, 14046, 10119, 2311, 18, 3]}, "items": [{"id": "p_4787", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_4788", "content": "sulphasalazine [SEP] -ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment.", "tokenized_content": [2, 13528, 14046, 10119, 3, 17, 28573, 13, 2843, 27438, 27057, 2256, 27016, 7446, 1941, 13528, 14046, 10119, 2311, 18, 3]}, "items": [{"id": "p_4788", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_4789", "content": "ulcerative colitis [SEP] A 59-year-old woman with ulcerative colitis developed red eyes, pleural effusion, eosinophilia and urinary ", "tokenized_content": [2, 20428, 12087, 3, 43, 4777, 17, 2476, 17, 4156, 10440, 1956, 20428, 12087, 3530, 2312, 7127, 16, 14117, 17673, 16, 26887, 1930, 7075, 3]}, "items": [{"id": "p_4789", "content": "Colitis, Ulcerative [SEP] Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, th", "score": 1, "type": null, "tokenized_content": [2, 12087, 16, 20428, 3, 4531, 1927, 1920, 4120, 1988, 1977, 7700, 13184, 1942, 1920, 9680, 18, 2496, 3044, 3601, 3951, 11904, 16, 11635, 7633, 16, 1913, 3]}]}
{"query": {"id": "q_4790", "content": "red eyes [SEP] A 59-year-old woman with ulcerative colitis developed red eyes, pleural effusion, eosinophilia and urinary abnormalities after", "tokenized_content": [2, 2312, 7127, 3, 43, 4777, 17, 2476, 17, 4156, 10440, 1956, 20428, 12087, 3530, 2312, 7127, 16, 14117, 17673, 16, 26887, 1930, 7075, 6754, 2256, 3]}, "items": [{"id": "p_4790", "content": "Eye Diseases [SEP] Diseases affecting the eye.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3902, 3, 3902, 7359, 1920, 5723, 18, 3]}]}
{"query": {"id": "q_4791", "content": "pleural effusion [SEP] A 59-year-old woman with ulcerative colitis developed red eyes, pleural effusion, eosinophilia and urinary abnormalities after restarting of sul", "tokenized_content": [2, 14117, 17673, 3, 43, 4777, 17, 2476, 17, 4156, 10440, 1956, 20428, 12087, 3530, 2312, 7127, 16, 14117, 17673, 16, 26887, 1930, 7075, 6754, 2256, 27016, 7446, 1941, 1927, 9596, 3]}, "items": [{"id": "p_4791", "content": "Pleural Effusion [SEP] Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a si", "score": 1, "type": null, "tokenized_content": [2, 14117, 17673, 3, 2990, 1927, 5466, 1922, 1920, 14117, 8568, 3864, 2037, 9122, 2127, 19856, 1929, 2014, 18787, 1943, 2037, 1920, 14117, 7553, 18, 2176, 1977, 43, 5998, 3]}]}
{"query": {"id": "q_4792", "content": "eosinophilia [SEP] n with ulcerative colitis developed red eyes, pleural effusion, eosinophilia and urinary abnormalities after restarting of sulphasalazine tr", "tokenized_content": [2, 26887, 3, 56, 1956, 20428, 12087, 3530, 2312, 7127, 16, 14117, 17673, 16, 26887, 1930, 7075, 6754, 2256, 27016, 7446, 1941, 1927, 13528, 14046, 10119, 2025, 3]}, "items": [{"id": "p_4792", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_4793", "content": "urinary abnormalities [SEP]  colitis developed red eyes, pleural effusion, eosinophilia and urinary abnormalities after restarting of sulphasalazine treatment. Light microscopy ", "tokenized_content": [2, 7075, 6754, 3, 12087, 3530, 2312, 7127, 16, 14117, 17673, 16, 26887, 1930, 7075, 6754, 2256, 27016, 7446, 1941, 1927, 13528, 14046, 10119, 2311, 18, 3696, 5441, 3]}, "items": [{"id": "p_4793", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_4794", "content": "sulphasalazine [SEP] ion, eosinophilia and urinary abnormalities after restarting of sulphasalazine treatment. Light microscopy of a kidney biopsy revealed segment", "tokenized_content": [2, 13528, 14046, 10119, 3, 4755, 16, 26887, 1930, 7075, 6754, 2256, 27016, 7446, 1941, 1927, 13528, 14046, 10119, 2311, 18, 3696, 5441, 1927, 43, 5245, 6831, 3404, 5367, 3]}, "items": [{"id": "p_4794", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_4795", "content": "segmental necrotizing glomerulonephritis [SEP] alazine treatment. Light microscopy of a kidney biopsy revealed segmental necrotizing glomerulonephritis without deposition of immunoglobulin or complement. Proteinase ", "tokenized_content": [2, 16294, 27438, 27057, 3, 10527, 22030, 2912, 2311, 18, 3696, 5441, 1927, 43, 5245, 6831, 3404, 16294, 27438, 27057, 2979, 7860, 1927, 11837, 2014, 5508, 18, 16172, 3]}, "items": [{"id": "p_4795", "content": "Glomerulosclerosis, Focal Segmental [SEP] A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary", "score": 1, "type": null, "tokenized_content": [2, 19268, 25081, 16, 8083, 16294, 3, 43, 17828, 4741, 2014, 4785, 2576, 1958, 43, 2601, 1927, 11655, 4047, 1988, 2258, 3137, 5092, 16, 3065, 2014, 4067, 3]}]}
{"query": {"id": "q_4796", "content": "pleural effusions [SEP] idase-ANCA was negative. PR3-ANCA titer was 250 and 1,070 EU in pleural effusions on right and left side, respectively. Although cessation of sul", "tokenized_content": [2, 14117, 17673, 1036, 3, 29930, 4127, 17, 28573, 1982, 3136, 18, 2033, 1010, 17, 28573, 13036, 1982, 6330, 1930, 21, 16, 6627, 1008, 4791, 1922, 14117, 17673, 1036, 1990, 3659, 3]}, "items": [{"id": "p_4796", "content": "Pleural Effusion [SEP] Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a si", "score": 1, "type": null, "tokenized_content": [2, 14117, 17673, 3, 2990, 1927, 5466, 1922, 1920, 14117, 8568, 3864, 2037, 9122, 2127, 19856, 1929, 2014, 18787, 1943, 2037, 1920, 14117, 7553, 18, 2176, 1977, 43, 5998, 3]}]}
{"query": {"id": "q_4797", "content": "fever [SEP] ssation of sulphasalazine treatment resulted in improvements in fever, red eyes, chest pain, titer of C-reactive protein and volume o", "tokenized_content": [2, 9087, 3, 19456, 1929, 1927, 13528, 14046, 10119, 2311, 4306, 1922, 8137, 1922, 9087, 16, 2312, 7127, 16, 8475, 3594, 16, 13036, 1927, 45, 17, 6079, 2213, 1930, 3776, 57, 3]}, "items": [{"id": "p_4797", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_4798", "content": "chest pain [SEP] salazine treatment resulted in improvements in fever, red eyes, chest pain, titer of C-reactive protein and volume of the pleural effusion", "tokenized_content": [2, 8475, 3594, 3, 3370, 10119, 2311, 4306, 1922, 8137, 1922, 9087, 16, 2312, 7127, 16, 8475, 3594, 16, 13036, 1927, 45, 17, 6079, 2213, 1930, 3776, 1927, 1920, 14117, 17673, 3]}, "items": [{"id": "p_4798", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_4799", "content": "steroid [SEP] ctive protein and volume of the pleural effusions, we initiated steroid therapy, because PR3-ANCA titer rose to 320 EU, eosinophil coun", "tokenized_content": [2, 9507, 3, 3369, 2320, 2213, 1930, 3776, 1927, 1920, 14117, 17673, 1036, 16, 2038, 7796, 9507, 3181, 16, 2882, 2033, 1010, 17, 28573, 13036, 13679, 1942, 15476, 4791, 16, 11510, 3]}, "items": [{"id": "p_4799", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4800", "content": "glomerulonephritis [SEP] ht microscopy of a kidney biopsy revealed segmental necrotizing glomerulonephritis without deposition of immunoglobulin or complement. Proteinase ", "tokenized_content": [2, 27057, 3, 5334, 5441, 1927, 43, 5245, 6831, 3404, 16294, 27438, 27057, 2979, 7860, 1927, 11837, 2014, 5508, 18, 16172, 3]}, "items": [{"id": "p_4800", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_4801", "content": "phenytoin [SEP] Is phenytoin administration safe in a hypothermic child?", "tokenized_content": [2, 3037, 30177, 3, 1977, 3037, 30177, 4183, 7672, 1922, 43, 16735, 4913, 2748, 35, 3]}, "items": [{"id": "p_4801", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_4802", "content": "hypothermic [SEP] Is phenytoin administration safe in a hypothermic child?", "tokenized_content": [2, 16735, 4913, 3, 1977, 3037, 30177, 4183, 7672, 1922, 43, 16735, 4913, 2748, 35, 3]}, "items": [{"id": "p_4802", "content": "Hypothermia [SEP] Lower than normal body temperature, especially in warm-blooded animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18750, 3, 2826, 2254, 2791, 3362, 3449, 16, 4369, 1922, 10142, 17, 2877, 1919, 3555, 18, 3]}]}
{"query": {"id": "q_4803", "content": "Chiari malformation [SEP] A male neonate with a Chiari malformation and a leaking myelomeningocoele underwent ventriculoperitoneal ", "tokenized_content": [2, 7368, 2205, 22138, 3, 43, 4005, 27586, 1956, 43, 7368, 2205, 22138, 1930, 43, 9186, 1941, 5707, 2932, 1941, 24724, 12015, 5468, 4699, 16058, 3556, 7855, 3]}, "items": [{"id": "p_4803", "content": "Arnold-Chiari Malformation [SEP] A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord, and surrounding bony structures. Typ", "score": 1, "type": null, "tokenized_content": [2, 26506, 2643, 17, 7368, 2205, 22138, 3, 43, 2210, 1927, 9901, 17360, 5884, 1920, 14938, 16, 12079, 16, 5199, 6071, 6670, 16, 1930, 7510, 18525, 4061, 18, 2357, 3]}]}
{"query": {"id": "q_4804", "content": "hypothermic [SEP] ing anaesthesia and surgery, he inadvertently became moderately hypothermic. Intravenous phenytoin was administered during the later part o", "tokenized_content": [2, 16735, 4913, 3, 30393, 17107, 1930, 3782, 16, 2234, 29574, 2512, 7935, 11224, 16735, 4913, 18, 7307, 3037, 30177, 1982, 5254, 2409, 1920, 3690, 3131, 57, 3]}, "items": [{"id": "p_4804", "content": "Hypothermia [SEP] Lower than normal body temperature, especially in warm-blooded animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18750, 3, 2826, 2254, 2791, 3362, 3449, 16, 4369, 1922, 10142, 17, 2877, 1919, 3555, 18, 3]}]}
{"query": {"id": "q_4805", "content": "phenytoin [SEP] ry, he inadvertently became moderately hypothermic. Intravenous phenytoin was administered during the later part of the surgery for seizu", "tokenized_content": [2, 3037, 30177, 3, 18650, 16, 2234, 29574, 2512, 7935, 11224, 16735, 4913, 18, 7307, 3037, 30177, 1982, 5254, 2409, 1920, 3690, 3131, 1927, 1920, 3782, 1958, 7563, 1032, 3]}, "items": [{"id": "p_4805", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_4806", "content": "seizure [SEP] ytoin was administered during the later part of the surgery for seizure prophylaxis. Following phenytoin administration, the patient de", "tokenized_content": [2, 11015, 3, 24412, 9024, 1982, 5254, 2409, 1920, 3690, 3131, 1927, 1920, 3782, 1958, 11015, 12725, 18, 2894, 3037, 30177, 4183, 16, 1920, 2774, 2028, 3]}, "items": [{"id": "p_4806", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4807", "content": "bradycardia [SEP] ng phenytoin administration, the patient developed acute severe bradycardia, refractory to atropine and adrenaline. The cardiac depressant ", "tokenized_content": [2, 26192, 3, 4375, 3037, 30177, 4183, 16, 1920, 2774, 3530, 3939, 4010, 26192, 16, 10923, 1942, 24031, 1930, 10651, 2053, 18, 1920, 4435, 20852, 2031, 3]}, "items": [{"id": "p_4807", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_4808", "content": "atropine [SEP] , the patient developed acute severe bradycardia, refractory to atropine and adrenaline. The cardiac depressant actions of phenytoin and", "tokenized_content": [2, 24031, 3, 16, 1920, 2774, 3530, 3939, 4010, 26192, 16, 10923, 1942, 24031, 1930, 10651, 2053, 18, 1920, 4435, 20852, 2031, 7728, 1927, 3037, 30177, 1930, 3]}, "items": [{"id": "p_4808", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_4809", "content": "adrenaline [SEP]  developed acute severe bradycardia, refractory to atropine and adrenaline. The cardiac depressant actions of phenytoin and hypothermia ca", "tokenized_content": [2, 10651, 2053, 3, 3530, 3939, 4010, 26192, 16, 10923, 1942, 24031, 1930, 10651, 2053, 18, 1920, 4435, 20852, 2031, 7728, 1927, 3037, 30177, 1930, 18750, 2332, 3]}, "items": [{"id": "p_4809", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_4810", "content": "hypothermia [SEP] and adrenaline. The cardiac depressant actions of phenytoin and hypothermia can be additive. Administration of phenytoin in the presence of", "tokenized_content": [2, 18750, 3, 1930, 10651, 2053, 18, 1920, 4435, 20852, 2031, 7728, 1927, 3037, 30177, 1930, 18750, 2112, 1998, 10359, 18, 4183, 1927, 3037, 30177, 1922, 1920, 2990, 1927, 3]}, "items": [{"id": "p_4810", "content": "Hypothermia [SEP] Lower than normal body temperature, especially in warm-blooded animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18750, 3, 2826, 2254, 2791, 3362, 3449, 16, 4369, 1922, 10142, 17, 2877, 1919, 3555, 18, 3]}]}
{"query": {"id": "q_4811", "content": "Amisulpride [SEP] Amisulpride related tic-like symptoms in an adolescent schizophrenic.", "tokenized_content": [2, 15665, 20490, 13857, 20332, 1021, 3, 15665, 20490, 13857, 20332, 1021, 2712, 18298, 17, 3189, 3601, 1922, 1925, 8402, 28247, 18, 3]}, "items": [{"id": "p_4811", "content": "sultopride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9596, 27747, 20332, 1021, 3, 3]}]}
{"query": {"id": "q_4812", "content": "tic-like symptoms [SEP] Amisulpride related tic-like symptoms in an adolescent schizophrenic.", "tokenized_content": [2, 18298, 17, 3189, 3601, 3, 15665, 20490, 13857, 20332, 1021, 2712, 18298, 17, 3189, 3601, 1922, 1925, 8402, 28247, 18, 3]}, "items": [{"id": "p_4812", "content": "Tic Disorders [SEP] Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythm", "score": 1, "type": null, "tokenized_content": [2, 18298, 4414, 3, 4414, 4378, 2007, 7457, 18298, 1036, 1988, 2278, 11827, 1956, 8560, 1930, 2303, 4209, 18, 18298, 1036, 2032, 12446, 16, 4052, 16, 22060, 10245, 1035, 3]}]}
{"query": {"id": "q_4813", "content": "schizophrenic [SEP] Amisulpride related tic-like symptoms in an adolescent schizophrenic.", "tokenized_content": [2, 28247, 3, 15665, 20490, 13857, 20332, 1021, 2712, 18298, 17, 3189, 3601, 1922, 1925, 8402, 28247, 18, 3]}, "items": [{"id": "p_4813", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_4814", "content": "Tic disorders [SEP] Tic disorders can be effectively treated by atypical antipsychotics such as r", "tokenized_content": [2, 18298, 4414, 3, 18298, 4414, 2112, 1998, 7098, 2868, 2007, 10834, 21474, 2427, 1966, 60, 3]}, "items": [{"id": "p_4814", "content": "Tic Disorders [SEP] Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythm", "score": 1, "type": null, "tokenized_content": [2, 18298, 4414, 3, 4414, 4378, 2007, 7457, 18298, 1036, 1988, 2278, 11827, 1956, 8560, 1930, 2303, 4209, 18, 18298, 1036, 2032, 12446, 16, 4052, 16, 22060, 10245, 1035, 3]}]}
{"query": {"id": "q_4815", "content": "risperidone [SEP] s can be effectively treated by atypical antipsychotics such as risperidone, olanzapine and ziprasidone. However, there are two case report", "tokenized_content": [2, 26991, 3, 61, 2112, 1998, 7098, 2868, 2007, 10834, 21474, 2427, 1966, 26991, 16, 26591, 1930, 14912, 29375, 15726, 18, 2406, 16, 2276, 2032, 2288, 3087, 3809, 3]}, "items": [{"id": "p_4815", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_4816", "content": "olanzapine [SEP] ctively treated by atypical antipsychotics such as risperidone, olanzapine and ziprasidone. However, there are two case reports that show ", "tokenized_content": [2, 26591, 3, 3369, 5102, 2868, 2007, 10834, 21474, 2427, 1966, 26991, 16, 26591, 1930, 14912, 29375, 15726, 18, 2406, 16, 2276, 2032, 2288, 3087, 4710, 1988, 2146, 3]}, "items": [{"id": "p_4816", "content": "olanzapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26591, 3, 3]}]}
{"query": {"id": "q_4817", "content": "ziprasidone [SEP]  by atypical antipsychotics such as risperidone, olanzapine and ziprasidone. However, there are two case reports that show tic-like symptom", "tokenized_content": [2, 14912, 29375, 15726, 3, 2007, 10834, 21474, 2427, 1966, 26991, 16, 26591, 1930, 14912, 29375, 15726, 18, 2406, 16, 2276, 2032, 2288, 3087, 4710, 1988, 2146, 18298, 17, 3189, 3226, 3]}, "items": [{"id": "p_4817", "content": "ziprasidone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14912, 29375, 15726, 3, 3]}]}
{"query": {"id": "q_4818", "content": "tic-like symptoms [SEP]  and ziprasidone. However, there are two case reports that show tic-like symptoms, including motor and phonic variants, occurring during treatmen", "tokenized_content": [2, 18298, 17, 3189, 3601, 3, 1930, 14912, 29375, 15726, 18, 2406, 16, 2276, 2032, 2288, 3087, 4710, 1988, 2146, 18298, 17, 3189, 3601, 16, 2710, 4842, 1930, 11999, 1935, 4936, 3]}, "items": [{"id": "p_4818", "content": "Tic Disorders [SEP] Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythm", "score": 1, "type": null, "tokenized_content": [2, 18298, 4414, 3, 4414, 4378, 2007, 7457, 18298, 1036, 1988, 2278, 11827, 1956, 8560, 1930, 2303, 4209, 18, 18298, 1036, 2032, 12446, 16, 4052, 16, 22060, 10245, 1035, 3]}]}
{"query": {"id": "q_4819", "content": "quetiapine [SEP] ding motor and phonic variants, occurring during treatment with quetiapine or clozapine. We present a 15-year-old girl schizophrenic who d", "tokenized_content": [2, 10730, 11574, 12184, 3, 27147, 4842, 1930, 11999, 1935, 4936, 16, 6966, 2409, 2311, 1956, 10730, 11574, 12184, 2014, 24424, 18, 2038, 2481, 43, 2461, 17, 2476, 17, 4156, 21676, 3]}, "items": [{"id": "p_4819", "content": "quetiapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10730, 11574, 12184, 3, 3]}]}
{"query": {"id": "q_4820", "content": "clozapine [SEP]  phonic variants, occurring during treatment with quetiapine or clozapine. We present a 15-year-old girl schizophrenic who developed freq", "tokenized_content": [2, 24424, 3, 11999, 1935, 4936, 16, 6966, 2409, 2311, 1956, 10730, 11574, 12184, 2014, 24424, 18, 2038, 2481, 43, 2461, 17, 2476, 17, 4156, 21676, 28247, 2746, 3530, 2805, 1055, 3]}, "items": [{"id": "p_4820", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_4821", "content": "schizophrenic [SEP] ent with quetiapine or clozapine. We present a 15-year-old girl schizophrenic who developed frequent involuntary eye-blinking movements after", "tokenized_content": [2, 28247, 3, 8496, 1956, 10730, 11574, 12184, 2014, 24424, 18, 2038, 2481, 43, 2461, 17, 2476, 17, 4156, 21676, 28247, 2746, 3530, 6439, 28493, 5723, 17, 23934, 1941, 8264, 2256, 3]}, "items": [{"id": "p_4821", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_4822", "content": "involuntary eye-blinking movements [SEP] present a 15-year-old girl schizophrenic who developed frequent involuntary eye-blinking movements after 5 months of amisulpride treatment (1000 mg per day). The ", "tokenized_content": [2, 28493, 5723, 17, 23934, 1941, 8264, 3, 2481, 43, 2461, 17, 2476, 17, 4156, 21676, 28247, 2746, 3530, 6439, 28493, 5723, 17, 23934, 1941, 8264, 2256, 25, 3221, 1927, 15665, 3]}, "items": [{"id": "p_4822", "content": "Dyskinesias [SEP] Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underly", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 1036, 3, 4552, 28493, 8264, 2154, 5985, 4081, 1920, 18884, 16, 13717, 16, 2014, 16795, 1988, 4704, 1966, 43, 15570, 1927, 1925, 9886, 1012, 3]}]}
{"query": {"id": "q_4823", "content": "amisulpride [SEP] d frequent involuntary eye-blinking movements after 5 months of amisulpride treatment (1000 mg per day). The tic-like symptoms resolved com", "tokenized_content": [2, 15665, 20490, 13857, 20332, 1021, 3, 46, 6439, 28493, 5723, 17, 23934, 1941, 8264, 2256, 25, 3221, 1927, 15665, 20490, 13857, 20332, 1021, 2311, 12, 5672, 2786, 2079, 3007, 13, 3]}, "items": [{"id": "p_4823", "content": "sultopride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9596, 27747, 20332, 1021, 3, 3]}]}
{"query": {"id": "q_4824", "content": "psychosis [SEP] ed the dose of amisulpride down to 800 mg per day. However, her psychosis recurred after the dose reduction. We then placed her on an add", "tokenized_content": [2, 15489, 3, 3347, 1920, 3253, 1927, 15665, 20490, 13857, 20332, 1021, 3292, 1942, 9658, 2786, 2079, 3007, 18, 2406, 16, 3656, 15489, 4734, 1919, 2256, 1920, 3253, 3378, 18, 2038, 3]}, "items": [{"id": "p_4824", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_4825", "content": "aspirin [SEP] Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms.", "tokenized_content": [2, 12396, 3, 3723, 1927, 5878, 23218, 1927, 12396, 12, 6894, 23880, 1935, 14523, 2687, 13, 1922, 3615, 2193, 3790, 10654, 17540, 18, 3]}, "items": [{"id": "p_4825", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4826", "content": "acetylsalicylic acid [SEP] Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms.", "tokenized_content": [2, 6894, 23880, 1935, 14523, 2687, 3, 3723, 1927, 5878, 23218, 1927, 12396, 12, 6894, 23880, 1935, 14523, 2687, 13, 1922, 3615, 2193, 3790, 10654, 17540, 18, 3]}, "items": [{"id": "p_4826", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4827", "content": "developmental anomalies [SEP] ti-inflammatory drugs (NSAIDs) suggests that a low incidence of developmental anomalies occurs in rats given NSAIDs on specific days during organogenes", "tokenized_content": [2, 5878, 13621, 3, 8685, 17, 3769, 4195, 12, 17739, 13, 4015, 1988, 43, 2330, 4332, 1927, 5878, 13621, 5110, 1922, 3615, 3258, 17739, 1990, 2487, 3000, 2409, 3090, 10864, 3]}, "items": [{"id": "p_4827", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_4828", "content": "Aspirin [SEP] urs in rats given NSAIDs on specific days during organogenesis. Aspirin (acetylsalicylic acid [ASA]), an irreversible cyclooxygenase 1 ", "tokenized_content": [2, 12396, 3, 29321, 1922, 3615, 3258, 17739, 1990, 2487, 3000, 2409, 3090, 3761, 18, 12396, 12, 6894, 23880, 1935, 14523, 2687, 37, 15634, 39, 13, 16, 1925, 14104, 21271, 21, 3]}, "items": [{"id": "p_4828", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4829", "content": "acetylsalicylic acid [SEP] ts given NSAIDs on specific days during organogenesis. Aspirin (acetylsalicylic acid [ASA]), an irreversible cyclooxygenase 1 and 2 inhibitor, induc", "tokenized_content": [2, 6894, 23880, 1935, 14523, 2687, 3, 4894, 3258, 17739, 1990, 2487, 3000, 2409, 3090, 3761, 18, 12396, 12, 6894, 23880, 1935, 14523, 2687, 37, 15634, 39, 13, 16, 1925, 14104, 3]}, "items": [{"id": "p_4829", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4830", "content": "ASA [SEP] cific days during organogenesis. Aspirin (acetylsalicylic acid [ASA]), an irreversible cyclooxygenase 1 and 2 inhibitor, induces de", "tokenized_content": [2, 15634, 3, 3371, 19894, 1030, 3000, 2409, 3090, 3761, 18, 12396, 12, 6894, 23880, 1935, 14523, 2687, 37, 15634, 39, 13, 16, 1925, 14104, 21271, 21, 1930, 22, 4106, 16, 3]}, "items": [{"id": "p_4830", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4831", "content": "gastrointestinal toxicity [SEP] anogenesis in SD rats; and to test the hypothesis that maternal gastrointestinal toxicity confounds the detection of low incidence malformations with ASA", "tokenized_content": [2, 8375, 5532, 3, 28976, 13349, 1922, 4035, 3615, 31, 1930, 1942, 2648, 1920, 4676, 1988, 5509, 8375, 5532, 10810, 1036, 1920, 3805, 1927, 2330, 4332, 17360, 1956, 15634, 3]}, "items": [{"id": "p_4831", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_4832", "content": "malformations [SEP] trointestinal toxicity confounds the detection of low incidence malformations with ASA when a multiple dosing paradigm is used. METHODS: ASA ", "tokenized_content": [2, 17360, 3, 12730, 8349, 5532, 10810, 1036, 1920, 3805, 1927, 2330, 4332, 17360, 1956, 15634, 2469, 43, 3137, 10654, 9930, 1977, 2251, 18, 2860, 30, 15634, 3]}, "items": [{"id": "p_4832", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_4833", "content": "ventricular septal defects [SEP] RESULTS: The literature evaluation suggested that NSAIDs induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hern", "tokenized_content": [2, 6493, 16458, 6007, 3, 2274, 30, 1920, 4431, 4391, 3978, 1988, 17739, 4769, 6493, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 3]}, "items": [{"id": "p_4833", "content": "Heart Septal Defects, Ventricular [SEP] Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower ", "score": 1, "type": null, "tokenized_content": [2, 4003, 16458, 6007, 16, 6493, 3, 5878, 6754, 1922, 2967, 7717, 1927, 1920, 6493, 17026, 3864, 1922, 4552, 20518, 2192, 1920, 2288, 2826, 3]}]}
{"query": {"id": "q_4834", "content": "VSDs [SEP] uation suggested that NSAIDs induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (DH", "tokenized_content": [2, 29075, 1036, 3, 17942, 1929, 3978, 1988, 17739, 4769, 6493, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 6781, 3]}, "items": [{"id": "p_4834", "content": "Heart Septal Defects, Ventricular [SEP] Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower ", "score": 1, "type": null, "tokenized_content": [2, 4003, 16458, 6007, 16, 6493, 3, 5878, 6754, 1922, 2967, 7717, 1927, 1920, 6493, 17026, 3864, 1922, 4552, 20518, 2192, 1920, 2288, 2826, 3]}]}
{"query": {"id": "q_4835", "content": "midline defects [SEP] gested that NSAIDs induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (DH), MDs, and VSDs in r", "tokenized_content": [2, 14210, 6007, 3, 6919, 1919, 1988, 17739, 4769, 6493, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 6781, 13, 16, 3]}, "items": [{"id": "p_4835", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4836", "content": "MDs [SEP] s induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (DH), MDs, and VSDs in rabbit", "tokenized_content": [2, 10697, 3, 61, 4769, 6493, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 6781, 13, 16, 10697, 16, 1930, 29075, 3]}, "items": [{"id": "p_4836", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4837", "content": "diaphragmatic hernia [SEP] lar septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (DH), MDs, and VSDs in rabbits (Cook JC et al., 2003); hence, t", "tokenized_content": [2, 29896, 17700, 3, 6590, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 6781, 13, 16, 10697, 16, 1930, 29075, 1036, 3]}, "items": [{"id": "p_4837", "content": "Hernias, Diaphragmatic, Congenital [SEP] Protrusion of abdominal structures into the THORAX as a result of embryologic defects in the DIAPHRAGM often present in the neon", "score": 1, "type": null, "tokenized_content": [2, 17700, 1036, 16, 29896, 16, 9901, 3, 24384, 1927, 6900, 4061, 2460, 1920, 23755, 1966, 43, 3211, 1927, 9222, 22284, 1935, 6007, 1922, 1920, 16108, 3868, 2481, 1922, 1920, 6621, 3]}]}
{"query": {"id": "q_4838", "content": "DH [SEP] Ds) and midline defects (MDs) in rats and diaphragmatic hernia (DH), MDs, and VSDs in rabbits (Cook JC et al., 2003); hence, the p", "tokenized_content": [2, 6781, 3, 4473, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 6781, 13, 16, 10697, 16, 1930, 29075, 1036, 1922, 11901, 12, 14943, 14904, 2140, 3]}, "items": [{"id": "p_4838", "content": "Hernias, Diaphragmatic, Congenital [SEP] Protrusion of abdominal structures into the THORAX as a result of embryologic defects in the DIAPHRAGM often present in the neon", "score": 1, "type": null, "tokenized_content": [2, 17700, 1036, 16, 29896, 16, 9901, 3, 24384, 1927, 6900, 4061, 2460, 1920, 23755, 1966, 43, 3211, 1927, 9222, 22284, 1935, 6007, 1922, 1920, 16108, 3868, 2481, 1922, 1920, 6621, 3]}]}
{"query": {"id": "q_4839", "content": "MD [SEP] s induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (DH), MDs, and VSDs in rabbi", "tokenized_content": [2, 4445, 3, 61, 4769, 6493, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 6781, 13, 16, 10697, 16, 1930, 29075, 3]}, "items": [{"id": "p_4839", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4840", "content": "VSD [SEP] uation suggested that NSAIDs induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (D", "tokenized_content": [2, 29075, 3, 17942, 1929, 3978, 1988, 17739, 4769, 6493, 16458, 6007, 12, 29075, 1036, 13, 1930, 14210, 6007, 12, 10697, 13, 1922, 3615, 1930, 29896, 17700, 12, 46, 3]}, "items": [{"id": "p_4840", "content": "Heart Septal Defects, Ventricular [SEP] Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower ", "score": 1, "type": null, "tokenized_content": [2, 4003, 16458, 6007, 16, 6493, 3, 5878, 6754, 1922, 2967, 7717, 1927, 1920, 6493, 17026, 3864, 1922, 4552, 20518, 2192, 1920, 2288, 2826, 3]}]}
{"query": {"id": "q_4841", "content": "hydrocephalus [SEP] SD rats were noted with the exception of VSD in the SD rats and hydrocephalus in the Wistar rats. Variations and malformations were similar w", "tokenized_content": [2, 24408, 3, 4035, 3615, 1985, 5040, 1956, 1920, 7541, 1927, 29075, 1922, 1920, 4035, 3615, 1930, 24408, 1922, 1920, 15668, 3615, 18, 6740, 1930, 17360, 1985, 2551, 65, 3]}, "items": [{"id": "p_4841", "content": "Hydrocephalus [SEP] Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, I", "score": 1, "type": null, "tokenized_content": [2, 24408, 3, 9122, 4858, 1927, 15448, 5466, 2651, 1920, 17586, 1989, 2154, 2278, 1998, 2458, 1956, 16470, 1927, 6329, 21008, 16, 51, 3]}]}
{"query": {"id": "q_4842", "content": "Torsade de pointes [SEP] Torsade de pointes induced by metoclopramide in an elderly woman with preexisting ", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 14823, 2873, 2028, 3575, 1918, 2719, 2007, 2130, 5406, 27148, 2261, 1922, 1925, 7354, 10440, 1956, 21604, 3]}, "items": [{"id": "p_4842", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_4843", "content": "metoclopramide [SEP] Torsade de pointes induced by metoclopramide in an elderly woman with preexisting complete left bundle branc", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 14823, 2873, 2028, 3575, 1918, 2719, 2007, 2130, 5406, 27148, 2261, 1922, 1925, 7354, 10440, 1956, 21604, 4080, 3506, 14142, 30344, 1030, 3]}, "items": [{"id": "p_4843", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_4844", "content": "left bundle branch block [SEP] by metoclopramide in an elderly woman with preexisting complete left bundle branch block.", "tokenized_content": [2, 3506, 14142, 6089, 3367, 3, 2007, 2130, 5406, 27148, 2261, 1922, 1925, 7354, 10440, 1956, 21604, 4080, 3506, 14142, 6089, 3367, 18, 3]}, "items": [{"id": "p_4844", "content": "Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU", "score": 1, "type": null, "tokenized_content": [2, 14142, 17, 6089, 3367, 3, 43, 2386, 1927, 4003, 3367, 1922, 2154, 1920, 8287, 4177, 1927, 4003, 21008, 1977, 20291, 2019, 3108, 2340, 1927, 1920, 11208, 1927, 3168, 3]}]}
{"query": {"id": "q_4845", "content": "long QT syndrome [SEP] There is a growing list of drugs implicated in acquired long QT syndrome and torsade de pointes. However, the torsadogenic potential of ", "tokenized_content": [2, 2815, 8877, 4741, 3, 2276, 1977, 43, 6552, 6069, 1927, 4195, 6835, 1922, 5815, 2815, 8877, 4741, 1930, 14823, 2873, 2028, 3575, 1918, 18, 2406, 16, 1920, 14823, 12595, 11216, 3]}, "items": [{"id": "p_4845", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_4846", "content": "torsade de pointes [SEP] owing list of drugs implicated in acquired long QT syndrome and torsade de pointes. However, the torsadogenic potential of metoclopramide, a commo", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 10762, 6069, 1927, 4195, 6835, 1922, 5815, 2815, 8877, 4741, 1930, 14823, 2873, 2028, 3575, 1918, 18, 2406, 16, 1920, 14823, 12595, 11216, 2889, 3]}, "items": [{"id": "p_4846", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_4847", "content": "metoclopramide [SEP]  and torsade de pointes. However, the torsadogenic potential of metoclopramide, a commonly used antiemetic and prokinetic drug, has not been r", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 1930, 14823, 2873, 2028, 3575, 1918, 18, 2406, 16, 1920, 14823, 12595, 11216, 2889, 1927, 2130, 5406, 27148, 2261, 16, 43, 5384, 2251, 2246, 17800, 3]}, "items": [{"id": "p_4847", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_4848", "content": "procainamide [SEP]  reported in the literature, despite its chemical similarity to procainamide. We report on a 92-year-old woman with preexisting complete lef", "tokenized_content": [2, 9823, 2005, 5482, 3, 2568, 1922, 1920, 4431, 16, 4281, 2496, 4399, 6796, 1942, 9823, 2005, 5482, 18, 2038, 3809, 1990, 43, 6224, 17, 2476, 17, 4156, 10440, 1956, 21604, 3]}, "items": [{"id": "p_4848", "content": "Procainamide [SEP] A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9823, 2005, 5482, 3, 43, 2921, 11640, 2246, 23246, 4913, 2838, 1988, 1977, 12171, 17, 2712, 1942, 9823, 5966, 18, 3]}]}
{"query": {"id": "q_4849", "content": "left bundle branch block [SEP] ide. We report on a 92-year-old woman with preexisting complete left bundle branch block who developed torsade de pointes after intravenous and oral adm", "tokenized_content": [2, 3506, 14142, 6089, 3367, 3, 9043, 18, 2038, 3809, 1990, 43, 6224, 17, 2476, 17, 4156, 10440, 1956, 21604, 4080, 3506, 14142, 6089, 3367, 2746, 3530, 14823, 2873, 2028, 3575, 3]}, "items": [{"id": "p_4849", "content": "Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU", "score": 1, "type": null, "tokenized_content": [2, 14142, 17, 6089, 3367, 3, 43, 2386, 1927, 4003, 3367, 1922, 2154, 1920, 8287, 4177, 1927, 4003, 21008, 1977, 20291, 2019, 3108, 2340, 1927, 1920, 11208, 1927, 3168, 3]}]}
{"query": {"id": "q_4850", "content": "cisapride [SEP] clopramide. This patient also developed torsade de pointes when cisapride and erythromycin were given simultaneously. These two episodes ", "tokenized_content": [2, 5848, 21358, 2261, 3, 20000, 29085, 2261, 18, 2052, 2774, 2222, 3530, 14823, 2873, 2028, 3575, 1918, 2469, 5848, 21358, 2261, 1930, 22925, 1985, 3258, 7159, 18, 2144, 2288, 9232, 3]}, "items": [{"id": "p_4850", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_4851", "content": "erythromycin [SEP] is patient also developed torsade de pointes when cisapride and erythromycin were given simultaneously. These two episodes were suppressed s", "tokenized_content": [2, 22925, 3, 1977, 2774, 2222, 3530, 14823, 2873, 2028, 3575, 1918, 2469, 5848, 21358, 2261, 1930, 22925, 1985, 3258, 7159, 18, 2144, 2288, 9232, 1985, 7657, 61, 3]}, "items": [{"id": "p_4851", "content": "Erythromycin [SEP] A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active componen", "score": 1, "type": null, "tokenized_content": [2, 22925, 3, 43, 14027, 14882, 7267, 23929, 2261, 4152, 2007, 22874, 6549, 1936, 1957, 18, 22925, 43, 1977, 3311, 2496, 3044, 3500, 3309, 1917, 3]}]}
{"query": {"id": "q_4852", "content": "Metoclopramide [SEP] ion that metoclopramide provokes torsade de pointes clinically. Metoclopramide should be used cautiously in patients with a risk of torsade de", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 4755, 1988, 2130, 5406, 27148, 2261, 2463, 18118, 14823, 2873, 2028, 3575, 1918, 5908, 18, 2130, 5406, 27148, 2261, 3066, 1998, 2251, 23402, 1954, 1922, 3]}, "items": [{"id": "p_4852", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_4853", "content": "Apomorphine [SEP] Apomorphine: an underutilized therapy for Parkinson's disease.", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 11466, 12492, 11119, 7969, 2912, 30, 1925, 2441, 1984, 8857, 3181, 1958, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_4853", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_4854", "content": "Parkinson's disease [SEP] Apomorphine: an underutilized therapy for Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 11466, 12492, 11119, 7969, 2912, 30, 1925, 2441, 1984, 8857, 3181, 1958, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_4854", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4855", "content": "Apomorphine [SEP] Apomorphine was the first dopaminergic drug ever used to treat symptoms of ", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 11466, 12492, 11119, 7969, 2912, 1982, 1920, 2561, 12214, 2838, 4264, 2251, 1942, 2297, 3601, 1927, 3]}, "items": [{"id": "p_4855", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_4856", "content": "Parkinson's disease [SEP]  was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as e", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 1982, 1920, 2561, 12214, 2838, 4264, 2251, 1942, 2297, 3601, 1927, 10124, 11, 61, 2573, 18, 2679, 9974, 24290, 14488, 6114, 1022, 2564, 2430, 2252, 3]}, "items": [{"id": "p_4856", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4857", "content": "apomorphine [SEP] uctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. A num", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 8577, 1031, 12169, 2104, 10124, 11, 61, 2573, 2007, 8634, 4183, 1927, 11466, 12492, 11119, 7969, 2912, 2258, 2444, 3998, 5433, 1920, 5198, 1927, 3]}, "items": [{"id": "p_4857", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_4858", "content": "levodopa [SEP] tiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-", "tokenized_content": [2, 26723, 3, 7933, 2566, 7941, 3122, 5580, 5428, 2647, 2084, 6119, 1942, 1988, 3945, 1956, 26723, 1930, 1988, 11466, 12492, 11119, 7969, 2912, 10162, 8775, 2112, 13445, 25939, 4013, 17, 3]}, "items": [{"id": "p_4858", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4859", "content": "dopamine [SEP] Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. Wh", "tokenized_content": [2, 7964, 3, 11466, 12492, 11119, 7969, 2912, 1982, 1920, 2561, 12214, 2838, 4264, 2251, 1942, 2297, 3601, 1927, 10124, 11, 61, 2573, 18, 2003, 3]}, "items": [{"id": "p_4859", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4860", "content": "dyskinesias [SEP] sociated with marked reductions of preexisting levodopa-induced dyskinesias. The main side effects of subcutaneous apomorphine treatment ar", "tokenized_content": [2, 3890, 26682, 1036, 3, 4744, 1981, 1956, 4961, 9350, 1927, 21604, 26723, 17, 2719, 3890, 26682, 1036, 18, 1920, 2730, 4159, 2564, 1927, 8634, 11466, 12492, 11119, 7969, 2912, 2311, 3]}, "items": [{"id": "p_4860", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4861", "content": "psychiatric [SEP] elated to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. Given the marked degree of ef", "tokenized_content": [2, 7652, 3, 2349, 1981, 1942, 11276, 17934, 4951, 16, 3417, 15263, 1930, 7652, 5021, 3918, 43, 11318, 2770, 18, 3258, 1920, 4961, 4647, 1927, 8485, 3]}, "items": [{"id": "p_4861", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4862", "content": "delirium [SEP] Fatal excited delirium following cocaine use: epidemiologic findings provide new evide", "tokenized_content": [2, 18166, 3, 11990, 14043, 18166, 2894, 9045, 2485, 30, 15574, 3056, 3394, 2814, 9274, 1021, 3]}, "items": [{"id": "p_4862", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_4863", "content": "cocaine [SEP] Fatal excited delirium following cocaine use: epidemiologic findings provide new evidence for mechanisms", "tokenized_content": [2, 9045, 3, 11990, 14043, 18166, 2894, 9045, 2485, 30, 15574, 3056, 3394, 2814, 3095, 1958, 3531, 3]}, "items": [{"id": "p_4863", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4864", "content": "toxicity [SEP] iologic findings provide new evidence for mechanisms of cocaine toxicity.", "tokenized_content": [2, 5532, 3, 23041, 2021, 1935, 3056, 3394, 2814, 3095, 1958, 3531, 1927, 9045, 5532, 18, 3]}, "items": [{"id": "p_4864", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4865", "content": "cocaine [SEP] We describe an outbreak of deaths from cocaine-induced excited delirium (EDDs) in Dade County, Florida between", "tokenized_content": [2, 9045, 3, 2038, 5993, 1925, 9571, 1927, 7601, 2037, 9045, 17, 2719, 14043, 18166, 12, 3347, 3134, 13, 1922, 23053, 1021, 11988, 16, 19386, 2192, 3]}, "items": [{"id": "p_4865", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4866", "content": "delirium [SEP] We describe an outbreak of deaths from cocaine-induced excited delirium (EDDs) in Dade County, Florida between 1979 and 1990. From a re", "tokenized_content": [2, 18166, 3, 2038, 5993, 1925, 9571, 1927, 7601, 2037, 9045, 17, 2719, 14043, 18166, 12, 3347, 3134, 13, 1922, 23053, 1021, 11988, 16, 19386, 2192, 15558, 1930, 7804, 18, 2037, 3]}, "items": [{"id": "p_4866", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_4867", "content": "EDDs [SEP] be an outbreak of deaths from cocaine-induced excited delirium (EDDs) in Dade County, Florida between 1979 and 1990. From a registry", "tokenized_content": [2, 3347, 3134, 3, 1998, 1925, 9571, 1927, 7601, 2037, 9045, 17, 2719, 14043, 18166, 12, 3347, 3134, 13, 1922, 23053, 1021, 11988, 16, 19386, 2192, 15558, 1930, 7804, 18, 2037, 3]}, "items": [{"id": "p_4867", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_4868", "content": "overdose [SEP] 0, 58 EDDs were compared with 125 victims of accidental cocaine overdose without excited delirium. Compared with controls, EDDs were mor", "tokenized_content": [2, 21090, 3, 20, 16, 4804, 3347, 3134, 1985, 2452, 1956, 7151, 17950, 1927, 24842, 9045, 21090, 2979, 14043, 18166, 18, 2452, 1956, 3562, 16, 3347, 3134, 1985, 2803, 3]}, "items": [{"id": "p_4868", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4869", "content": "hyperthermia [SEP]  death, to have survived for a longer period, to have developed hyperthermia, and to have died in summer months. EDDs had concentrations of ", "tokenized_content": [2, 21945, 3, 3539, 16, 1942, 2162, 13985, 1958, 43, 4872, 3047, 16, 1942, 2162, 3530, 21945, 16, 1930, 1942, 2162, 8545, 1922, 12495, 3221, 18, 3347, 3134, 2430, 3295, 1927, 3]}, "items": [{"id": "p_4869", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_4870", "content": "benzoylecgonine [SEP] e died in summer months. EDDs had concentrations of cocaine and benzoylecgonine in autopsy blood that were similar to those for controls. The e", "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 47, 8545, 1922, 12495, 3221, 18, 3347, 3134, 2430, 3295, 1927, 9045, 1930, 19225, 6752, 1030, 3827, 8635, 2912, 1922, 16740, 2877, 1988, 3]}, "items": [{"id": "p_4870", "content": "benzoylecgonine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 3]}]}
{"query": {"id": "q_4871", "content": "agitation [SEP] tion and, when coupled with recent cocaine use, may precipitate agitation, delirium, aberrant thermoregulation, rhabdomyolysis, and sudde", "tokenized_content": [2, 18389, 3, 8685, 1916, 1930, 16, 2469, 6416, 1956, 3505, 9045, 2485, 16, 2278, 18290, 18389, 16, 18166, 16, 9801, 7967, 3127, 2281, 16, 25369, 6892, 16, 1930, 9601, 3695, 3]}, "items": [{"id": "p_4871", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_4872", "content": "rhabdomyolysis [SEP] may precipitate agitation, delirium, aberrant thermoregulation, rhabdomyolysis, and sudden death.", "tokenized_content": [2, 25369, 6892, 3, 2278, 18290, 18389, 16, 18166, 16, 9801, 7967, 3127, 2281, 16, 25369, 6892, 16, 1930, 12446, 3539, 18, 3]}, "items": [{"id": "p_4872", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_4873", "content": "sudden death [SEP] ation, delirium, aberrant thermoregulation, rhabdomyolysis, and sudden death.", "tokenized_content": [2, 12446, 3539, 3, 2019, 2001, 16, 18166, 16, 9801, 7967, 3127, 2281, 16, 25369, 6892, 16, 1930, 12446, 3539, 18, 3]}, "items": [{"id": "p_4873", "content": "Death, Sudden [SEP] The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiov", "score": 1, "type": null, "tokenized_content": [2, 3539, 16, 12446, 3, 1920, 20135, 10975, 1927, 2136, 8970, 23792, 4088, 16, 16687, 2007, 1920, 11047, 3257, 1927, 2698, 6329, 16, 5481, 16, 1930, 21129, 1020, 3]}]}
{"query": {"id": "q_4874", "content": "Heparin [SEP] Heparin-induced thrombocytopenia, thrombosis, and hemorrhage.", "tokenized_content": [2, 9962, 3, 9962, 17, 2719, 17100, 16, 11354, 16, 1930, 10489, 18, 3]}, "items": [{"id": "p_4874", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4875", "content": "thrombocytopenia [SEP] Heparin-induced thrombocytopenia, thrombosis, and hemorrhage.", "tokenized_content": [2, 17100, 3, 9962, 17, 2719, 17100, 16, 11354, 16, 1930, 10489, 18, 3]}, "items": [{"id": "p_4875", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_4876", "content": "thrombosis [SEP] Heparin-induced thrombocytopenia, thrombosis, and hemorrhage.", "tokenized_content": [2, 11354, 3, 9962, 17, 2719, 17100, 16, 11354, 16, 1930, 10489, 18, 3]}, "items": [{"id": "p_4876", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_4877", "content": "hemorrhage [SEP] Heparin-induced thrombocytopenia, thrombosis, and hemorrhage.", "tokenized_content": [2, 10489, 3, 9962, 17, 2719, 17100, 16, 11354, 16, 1930, 10489, 18, 3]}, "items": [{"id": "p_4877", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4878", "content": "heparin [SEP] Sixty-two patients with a heparin-induced thrombocytopenia are reported. Clinical manifestations ", "tokenized_content": [2, 9962, 3, 14063, 17, 2288, 2132, 1956, 43, 9962, 17, 2719, 17100, 2032, 2568, 18, 2535, 10952, 3]}, "items": [{"id": "p_4878", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4879", "content": "thrombocytopenia [SEP] Sixty-two patients with a heparin-induced thrombocytopenia are reported. Clinical manifestations of this disorder include ", "tokenized_content": [2, 17100, 3, 14063, 17, 2288, 2132, 1956, 43, 9962, 17, 2719, 17100, 2032, 2568, 18, 2535, 10952, 1927, 2052, 4770, 3951, 3]}, "items": [{"id": "p_4879", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_4880", "content": "hemorrhage [SEP]  are reported. Clinical manifestations of this disorder include hemorrhage or, more frequently, thromboembolic events in patients receivin", "tokenized_content": [2, 10489, 3, 2032, 2568, 18, 2535, 10952, 1927, 2052, 4770, 3951, 10489, 2014, 16, 2253, 5467, 16, 25580, 3916, 1922, 2132, 3169, 2068, 1921, 3]}, "items": [{"id": "p_4880", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4881", "content": "thromboembolic [SEP] ations of this disorder include hemorrhage or, more frequently, thromboembolic events in patients receiving heparin. Laboratory testing has re", "tokenized_content": [2, 25580, 3, 2019, 2443, 1927, 2052, 4770, 3951, 10489, 2014, 16, 2253, 5467, 16, 25580, 3916, 1922, 2132, 5962, 9962, 18, 4542, 4213, 2258, 1964, 3]}, "items": [{"id": "p_4881", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_4882", "content": "a falling platelet count [SEP]  in patients receiving heparin. Laboratory testing has revealed a falling platelet count, increased resistance to heparin, and aggregation of platelets ", "tokenized_content": [2, 43, 16701, 7163, 6500, 3, 1922, 2132, 5962, 9962, 18, 4542, 4213, 2258, 3404, 43, 16701, 7163, 6500, 16, 2502, 3554, 1942, 9962, 16, 1930, 7883, 1927, 10097, 3]}, "items": [{"id": "p_4882", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_4883", "content": "thromboembolic complications [SEP] t platelet membrane antibody. The 20 deaths, 52 hemorrhagic and thromboembolic complications, and 21 surgical procedures to manage the complications confirm", "tokenized_content": [2, 25580, 5021, 3, 62, 7163, 3260, 3533, 18, 1920, 2036, 7601, 16, 4764, 16052, 1930, 25580, 5021, 16, 1930, 2900, 4548, 4869, 1942, 12193, 1920, 5021, 4763, 3]}, "items": [{"id": "p_4883", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_4884", "content": "platelet aggregation [SEP]  less than 100,000/mm3, while the patient is receiving heparin, platelet aggregation testing, using the patient's plasma, is indicated. Management c", "tokenized_content": [2, 7163, 7883, 3, 2941, 2254, 2813, 16, 3240, 19, 14226, 16, 2679, 1920, 2774, 1977, 5962, 9962, 16, 7163, 7883, 4213, 16, 2193, 1920, 2774, 11, 61, 3582, 16, 1977, 3]}, "items": [{"id": "p_4884", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_4885", "content": "Cardiac toxicity [SEP] Cardiac toxicity of 5-fluorouracil. Report of a case of spontaneous angina.", "tokenized_content": [2, 4435, 5532, 3, 4435, 5532, 1927, 25, 17, 21353, 18, 3809, 1927, 43, 3087, 1927, 6242, 16961, 18, 3]}, "items": [{"id": "p_4885", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4886", "content": "5-fluorouracil [SEP] Cardiac toxicity of 5-fluorouracil. Report of a case of spontaneous angina.", "tokenized_content": [2, 25, 17, 21353, 3, 4435, 5532, 1927, 25, 17, 21353, 18, 3809, 1927, 43, 3087, 1927, 6242, 16961, 18, 3]}, "items": [{"id": "p_4886", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_4887", "content": "angina [SEP] iac toxicity of 5-fluorouracil. Report of a case of spontaneous angina.", "tokenized_content": [2, 16961, 3, 20320, 5532, 1927, 25, 17, 21353, 18, 3809, 1927, 43, 3087, 1927, 6242, 16961, 18, 3]}, "items": [{"id": "p_4887", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_4888", "content": "colon carcinoma [SEP] We report a case of a patient with colon carcinoma and liver metastasis who presented chest pain after 5-fluoroura", "tokenized_content": [2, 4120, 5373, 3, 2038, 3809, 43, 3087, 1927, 43, 2774, 1956, 4120, 5373, 1930, 3568, 5967, 2746, 3549, 8475, 3594, 2256, 25, 17, 16191, 9280, 3]}, "items": [{"id": "p_4888", "content": "Colonic Neoplasms [SEP] Tumors or cancer of the COLON.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12401, 15347, 3, 3861, 2014, 2539, 1927, 1920, 4120, 18, 3]}]}
{"query": {"id": "q_4889", "content": "metastasis [SEP] We report a case of a patient with colon carcinoma and liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administra", "tokenized_content": [2, 5967, 3, 2038, 3809, 43, 3087, 1927, 43, 2774, 1956, 4120, 5373, 1930, 3568, 5967, 2746, 3549, 8475, 3594, 2256, 25, 17, 21353, 12, 25, 17, 7391, 13, 10473, 1019, 3]}, "items": [{"id": "p_4889", "content": "Neoplasm Metastasis [SEP] The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12132, 5967, 3, 1920, 3856, 1927, 43, 12132, 2037, 2340, 3090, 2014, 3131, 1927, 1920, 3362, 1942, 3741, 12597, 2037, 1920, 3065, 3200, 18, 3]}]}
{"query": {"id": "q_4890", "content": "chest pain [SEP] patient with colon carcinoma and liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administration. Clinical electrocar", "tokenized_content": [2, 8475, 3594, 3, 2774, 1956, 4120, 5373, 1930, 3568, 5967, 2746, 3549, 8475, 3594, 2256, 25, 17, 21353, 12, 25, 17, 7391, 13, 4183, 18, 2535, 13142, 1933, 3]}, "items": [{"id": "p_4890", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_4891", "content": "5-fluorouracil [SEP] n carcinoma and liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administration. Clinical electrocardiographic evolution ", "tokenized_content": [2, 25, 17, 21353, 3, 56, 5373, 1930, 3568, 5967, 2746, 3549, 8475, 3594, 2256, 25, 17, 21353, 12, 25, 17, 7391, 13, 4183, 18, 2535, 15894, 4158, 4854, 3]}, "items": [{"id": "p_4891", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_4892", "content": "5-FU [SEP] liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administration. Clinical electrocardiographic evolution was si", "tokenized_content": [2, 25, 17, 7391, 3, 3568, 5967, 2746, 3549, 8475, 3594, 2256, 25, 17, 21353, 12, 25, 17, 7391, 13, 4183, 18, 2535, 15894, 4158, 4854, 1982, 5998, 3]}, "items": [{"id": "p_4892", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_4893", "content": "Prinzmetal's angina [SEP]  electrocardiographic evolution was similar to that observed in Prinzmetal's angina, and chest pain promptly resolved with nifedipine. These data s", "tokenized_content": [2, 7805, 1011, 14578, 1923, 11, 61, 16961, 3, 15894, 4158, 4854, 1982, 2551, 1942, 1988, 2528, 1922, 7805, 1011, 14578, 1923, 11, 61, 16961, 16, 1930, 8475, 3594, 29594, 8397, 3]}, "items": [{"id": "p_4893", "content": "Angina Pectoris, Variant [SEP] A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in th", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 16, 6031, 3, 43, 2535, 4741, 4378, 2007, 1920, 2740, 1927, 8475, 3594, 2019, 6172, 1956, 8537, 6809, 1955, 5367, 8644, 1922, 1913, 3]}]}
{"query": {"id": "q_4894", "content": "nifedipine [SEP] d in Prinzmetal's angina, and chest pain promptly resolved with nifedipine. These data suggest that coronary spasm may be the cause of car", "tokenized_content": [2, 25968, 3, 46, 1922, 7805, 1011, 14578, 1923, 11, 61, 16961, 16, 1930, 8475, 3594, 29594, 8397, 1956, 25968, 18, 2144, 2230, 3220, 1988, 5846, 24431, 2278, 1998, 1920, 3936, 3]}, "items": [{"id": "p_4894", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4895", "content": "coronary spasm [SEP] pain promptly resolved with nifedipine. These data suggest that coronary spasm may be the cause of cardiotoxicity due to 5-FU, and that calciu", "tokenized_content": [2, 5846, 24431, 3, 3594, 29594, 8397, 1956, 25968, 18, 2144, 2230, 3220, 1988, 5846, 24431, 2278, 1998, 1920, 3936, 1927, 30490, 2810, 1942, 25, 17, 7391, 16, 1930, 1988, 2799, 3]}, "items": [{"id": "p_4895", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_4896", "content": "cardiotoxicity [SEP] ine. These data suggest that coronary spasm may be the cause of cardiotoxicity due to 5-FU, and that calcium antagonists may probably be used ", "tokenized_content": [2, 30490, 3, 11116, 18, 2144, 2230, 3220, 1988, 5846, 24431, 2278, 1998, 1920, 3936, 1927, 30490, 2810, 1942, 25, 17, 7391, 16, 1930, 1988, 5016, 10515, 2278, 6226, 1998, 2251, 3]}, "items": [{"id": "p_4896", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4897", "content": "calcium [SEP]  spasm may be the cause of cardiotoxicity due to 5-FU, and that calcium antagonists may probably be used in the prevention or treatment", "tokenized_content": [2, 5016, 3, 24431, 2278, 1998, 1920, 3936, 1927, 30490, 2810, 1942, 25, 17, 7391, 16, 1930, 1988, 5016, 10515, 2278, 6226, 1998, 2251, 1922, 1920, 5455, 2014, 2311, 3]}, "items": [{"id": "p_4897", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_4898", "content": "Toxicity [SEP] Toxicity due to remission inducing drugs in rheumatoid arthritis. Associ", "tokenized_content": [2, 5532, 3, 5532, 2810, 1942, 10221, 7834, 4195, 1922, 13053, 8884, 18, 2293, 3]}, "items": [{"id": "p_4898", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4899", "content": "rheumatoid arthritis [SEP] Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens.", "tokenized_content": [2, 13053, 8884, 3, 5532, 2810, 1942, 10221, 7834, 4195, 1922, 13053, 8884, 18, 3279, 1956, 7225, 17, 16563, 1015, 1930, 13198, 1006, 7769, 18, 3]}, "items": [{"id": "p_4899", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_4900", "content": "rheumatoid arthritis [SEP] Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing dru", "tokenized_content": [2, 13053, 8884, 3, 7639, 17, 3628, 2132, 1956, 13053, 8884, 12, 4313, 13, 2746, 3530, 5532, 2679, 6303, 10221, 7834, 2324, 1032, 3]}, "items": [{"id": "p_4900", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_4901", "content": "RA [SEP] Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs a", "tokenized_content": [2, 4313, 3, 7639, 17, 3628, 2132, 1956, 13053, 8884, 12, 4313, 13, 2746, 3530, 5532, 2679, 6303, 10221, 7834, 4195, 43, 3]}, "items": [{"id": "p_4901", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_4902", "content": "toxicity [SEP] enty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity w", "tokenized_content": [2, 5532, 3, 8496, 1012, 17, 3628, 2132, 1956, 13053, 8884, 12, 4313, 13, 2746, 3530, 5532, 2679, 6303, 10221, 7834, 4195, 1930, 2627, 2979, 5532, 65, 3]}, "items": [{"id": "p_4902", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4903", "content": "nephritis [SEP] nd II HLA antigens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compoun", "tokenized_content": [2, 25064, 3, 8026, 2890, 7225, 7769, 18, 43, 3206, 3279, 2258, 2252, 2435, 2192, 25064, 1930, 18006, 2810, 1942, 8685, 12964, 8635, 1022, 12, 43, 46, 17, 25142, 3812, 3189, 3]}, "items": [{"id": "p_4903", "content": "Nephritis [SEP] Inflammation of any part of the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25064, 3, 4531, 1927, 2967, 3131, 1927, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_4904", "content": "dermatitis [SEP] gens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I ", "tokenized_content": [2, 18006, 3, 2065, 1036, 18, 43, 3206, 3279, 2258, 2252, 2435, 2192, 25064, 1930, 18006, 2810, 1942, 8685, 12964, 8635, 1022, 12, 43, 46, 17, 25142, 3812, 3189, 3547, 13, 3]}, "items": [{"id": "p_4904", "content": "Dermatitis [SEP] Any inflammation of the skin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18006, 3, 2967, 4531, 1927, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_4905", "content": "Tiopronin [SEP] ociation has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4,", "tokenized_content": [2, 8685, 12964, 8635, 1022, 3, 5084, 13196, 2258, 2252, 2435, 2192, 25064, 1930, 18006, 2810, 1942, 8685, 12964, 8635, 1022, 12, 43, 46, 17, 25142, 3812, 3189, 3547, 13, 1930, 3]}, "items": [{"id": "p_4905", "content": "Tiopronin [SEP] Sulfhydryl acylated derivative of GLYCINE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8685, 12964, 8635, 1022, 3, 30011, 2199, 11337, 1981, 10533, 1927, 10646, 18, 3]}]}
{"query": {"id": "q_4906", "content": "D-Penicillamine [SEP] been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4, and between dermat", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 2252, 2435, 2192, 25064, 1930, 18006, 2810, 1942, 8685, 12964, 8635, 1022, 12, 43, 46, 17, 25142, 3812, 3189, 3547, 13, 1930, 2921, 51, 7769, 3]}, "items": [{"id": "p_4906", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_4907", "content": "gold [SEP] nd) and class I antigens B35-Cw4, and between dermatitis due to gold thiosulphate and B35. Compared to healthy controls a lower DR5 ", "tokenized_content": [2, 6557, 3, 8026, 13, 1930, 2921, 51, 7769, 16563, 1015, 17, 13198, 1006, 16, 1930, 2192, 18006, 2810, 1942, 6557, 15331, 20490, 13857, 2722, 2057, 1930, 16563, 1015, 18, 2452, 3]}, "items": [{"id": "p_4907", "content": "Gold [SEP] A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating", "score": 1, "type": null, "tokenized_content": [2, 6557, 3, 43, 7463, 16790, 6149, 1956, 1920, 11241, 17530, 5759, 16, 11241, 2529, 5637, 16, 1930, 11241, 3388, 5876, 18, 2176, 1977, 2251, 1922, 28296, 1938, 6907, 16, 6557, 8516, 1029, 3]}]}
{"query": {"id": "q_4908", "content": "hemiparesis [SEP] Transient hemiparesis: a rare manifestation of diphenylhydantoin toxicity. Report of ", "tokenized_content": [2, 22637, 9392, 1937, 3, 6809, 22637, 9392, 1937, 30, 43, 5844, 15570, 1927, 18190, 3963, 26182, 1921, 5532, 18, 3809, 1927, 3]}, "items": [{"id": "p_4908", "content": "Paresis [SEP] A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe", "score": 1, "type": null, "tokenized_content": [2, 2096, 2600, 3, 43, 3335, 2576, 17714, 1942, 43, 5809, 1942, 5086, 4647, 1927, 12330, 12175, 16, 14647, 2251, 1966, 43, 26023, 1958, 18973, 12, 4010, 3]}]}
{"query": {"id": "q_4909", "content": "diphenylhydantoin [SEP] Transient hemiparesis: a rare manifestation of diphenylhydantoin toxicity. Report of two cases.", "tokenized_content": [2, 18190, 3963, 26182, 1921, 3, 6809, 22637, 9392, 1937, 30, 43, 5844, 15570, 1927, 18190, 3963, 26182, 1921, 5532, 18, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_4909", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_4910", "content": "toxicity [SEP] ransient hemiparesis: a rare manifestation of diphenylhydantoin toxicity. Report of two cases.", "tokenized_content": [2, 5532, 3, 2845, 12924, 1939, 22637, 9392, 1937, 30, 43, 5844, 15570, 1927, 18190, 3963, 26182, 1921, 5532, 18, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_4910", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4911", "content": "diphenylhydantoin [SEP] Among the common side effects of diphenylhydantoin (DPH) overdose, the most frequently encountered neurological si", "tokenized_content": [2, 18190, 3963, 26182, 1921, 3, 2706, 1920, 3059, 4159, 2564, 1927, 18190, 3963, 26182, 1921, 12, 5679, 1023, 13, 21090, 16, 1920, 2501, 5467, 11989, 7605, 5998, 3]}, "items": [{"id": "p_4911", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_4912", "content": "DPH [SEP] Among the common side effects of diphenylhydantoin (DPH) overdose, the most frequently encountered neurological signs a", "tokenized_content": [2, 5679, 1023, 3, 2706, 1920, 3059, 4159, 2564, 1927, 18190, 3963, 26182, 1921, 12, 5679, 1023, 13, 21090, 16, 1920, 2501, 5467, 11989, 7605, 6879, 43, 3]}, "items": [{"id": "p_4912", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_4913", "content": "overdose [SEP] Among the common side effects of diphenylhydantoin (DPH) overdose, the most frequently encountered neurological signs are those o", "tokenized_content": [2, 21090, 3, 2706, 1920, 3059, 4159, 2564, 1927, 18190, 3963, 26182, 1921, 12, 5679, 1023, 13, 21090, 16, 1920, 2501, 5467, 11989, 7605, 6879, 2032, 2690, 57, 3]}, "items": [{"id": "p_4913", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4914", "content": "cerebellar dysfunction [SEP] the most frequently encountered neurological signs are those of cerebellar dysfunction. Very rarely, the toxic neurological manifestations of this dru", "tokenized_content": [2, 11459, 5273, 3, 1920, 2501, 5467, 11989, 7605, 6879, 2032, 2690, 1927, 11459, 5273, 18, 3345, 9671, 16, 1920, 6161, 7605, 10952, 1927, 2052, 2324, 1032, 3]}, "items": [{"id": "p_4914", "content": "Cerebellar Diseases [SEP] Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysm", "score": 1, "type": null, "tokenized_content": [2, 11459, 3902, 3, 3902, 1988, 4081, 1920, 3170, 2014, 2347, 1927, 1920, 12079, 18, 27529, 10952, 1927, 11459, 5273, 3951, 26906, 3]}]}
{"query": {"id": "q_4915", "content": "hemiparesis [SEP] ral origin. Two patients are presented who suffered progressive hemiparesis due to DPH overdose. Both had brain surgery before DPH treatmen", "tokenized_content": [2, 22637, 9392, 1937, 3, 15906, 4853, 18, 2288, 2132, 2032, 3549, 2746, 13949, 7529, 22637, 9392, 1937, 2810, 1942, 5679, 1023, 21090, 18, 2321, 2430, 3068, 3782, 3119, 5679, 1023, 3]}, "items": [{"id": "p_4915", "content": "Paresis [SEP] A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe", "score": 1, "type": null, "tokenized_content": [2, 2096, 2600, 3, 43, 3335, 2576, 17714, 1942, 43, 5809, 1942, 5086, 4647, 1927, 12330, 12175, 16, 14647, 2251, 1966, 43, 26023, 1958, 18973, 12, 4010, 3]}]}
{"query": {"id": "q_4916", "content": "cerebral damage [SEP] ery before DPH treatment. It is assumed that patients with some cerebral damage are liable to manifest DPH toxicity as focal neurological signs", "tokenized_content": [2, 6329, 4293, 3, 2668, 1012, 3119, 5679, 1023, 2311, 18, 2176, 1977, 7696, 1988, 2132, 1956, 2673, 6329, 4293, 2032, 25700, 7272, 1942, 7943, 5679, 1023, 5532, 1966, 8083, 7605, 3]}, "items": [{"id": "p_4916", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_4917", "content": "toxicity [SEP] t patients with some cerebral damage are liable to manifest DPH toxicity as focal neurological signs.", "tokenized_content": [2, 5532, 3, 62, 2132, 1956, 2673, 6329, 4293, 2032, 25700, 7272, 1942, 7943, 5679, 1023, 5532, 1966, 8083, 7605, 6879, 18, 3]}, "items": [{"id": "p_4917", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4918", "content": "prostaglandins [SEP] Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder.", "tokenized_content": [2, 25674, 3, 5507, 2905, 2991, 1930, 25674, 1922, 1920, 6960, 1927, 4232, 2132, 1956, 2338, 3849, 7821, 18, 3]}, "items": [{"id": "p_4918", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_4919", "content": "overactive bladder [SEP]  factor and prostaglandins in the urine of female patients with overactive bladder.", "tokenized_content": [2, 2338, 3849, 7821, 3, 2991, 1930, 25674, 1922, 1920, 6960, 1927, 4232, 2132, 1956, 2338, 3849, 7821, 18, 3]}, "items": [{"id": "p_4919", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_4920", "content": "PGs [SEP] PURPOSE: NGF and PGs in the bladder can be affected by pathological changes in the b", "tokenized_content": [2, 22571, 3, 5120, 30, 13741, 1930, 22571, 1922, 1920, 7821, 2112, 1998, 4218, 2007, 6598, 2840, 1922, 1920, 44, 3]}, "items": [{"id": "p_4920", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_4921", "content": "OAB [SEP] e. We investigated changes in urinary NGF and PGs in women with OAB. MATERIALS AND METHODS: The study groups included 65 women with", "tokenized_content": [2, 8965, 1014, 3, 47, 18, 2038, 3845, 2840, 1922, 7075, 13741, 1930, 22571, 1922, 3089, 1956, 8965, 1014, 18, 4751, 1930, 2860, 30, 1920, 2161, 2671, 3063, 4459, 3089, 1956, 3]}, "items": [{"id": "p_4921", "content": "Urinary Bladder, Overactive [SEP] Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overacti", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 16, 2338, 3849, 3, 3226, 1927, 2338, 3849, 11086, 1957, 1924, 3760, 1927, 1920, 7075, 7821, 1988, 14456, 1036, 1956, 20756, 2149, 3528, 1930, 24414, 18, 2338, 2131, 1033, 3]}]}
{"query": {"id": "q_4922", "content": "PGE2 [SEP] iary and urodynamic studies. Urine samples were collected. NGF, PGE2, PGF2alpha and PGI2 were measured using enzyme-linked immunosor", "tokenized_content": [2, 13790, 3, 11640, 6907, 1930, 14984, 14458, 12253, 1935, 2351, 18, 6960, 2785, 1985, 3651, 18, 13741, 16, 13790, 16, 21735, 5896, 13857, 2722, 1930, 5306, 15277, 1985, 3045, 2193, 3]}, "items": [{"id": "p_4922", "content": "Dinoprostone [SEP] The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteris", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 2290, 3, 1920, 2501, 3059, 1930, 2501, 12186, 3500, 1927, 1920, 6492, 25674, 18, 2176, 9826, 2501, 3933, 4209, 3327, 3]}]}
{"query": {"id": "q_4923", "content": "PGF2alpha [SEP] nd urodynamic studies. Urine samples were collected. NGF, PGE2, PGF2alpha and PGI2 were measured using enzyme-linked immunosorbent assay ", "tokenized_content": [2, 21735, 5896, 13857, 2722, 3, 8026, 14984, 14458, 12253, 1935, 2351, 18, 6960, 2785, 1985, 3651, 18, 13741, 16, 13790, 16, 21735, 5896, 13857, 2722, 1930, 5306, 15277, 1985, 3045, 3]}, "items": [{"id": "p_4923", "content": "Dinoprost [SEP] A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile prop", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 3, 43, 10414, 6966, 15900, 1988, 2258, 16462, 19977, 16, 12867, 6586, 16, 1930, 11380, 3058, 28278, 1939, 4209, 18, 2810, 1942, 2496, 22866, 12334, 10261, 2341, 2383, 5062, 3]}]}
{"query": {"id": "q_4924", "content": "PGI2 [SEP] studies. Urine samples were collected. NGF, PGE2, PGF2alpha and PGI2 were measured using enzyme-linked immunosorbent assay and compa", "tokenized_content": [2, 5306, 15277, 3, 2351, 18, 6960, 2785, 1985, 3651, 18, 13741, 16, 13790, 16, 21735, 5896, 13857, 2722, 1930, 5306, 15277, 1985, 3045, 2193, 4113, 17, 4624, 16083, 3381, 1930, 3]}, "items": [{"id": "p_4924", "content": "Epoprostenol [SEP] A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTA", "score": 1, "type": null, "tokenized_content": [2, 15751, 2216, 24690, 1945, 3, 43, 15900, 1988, 1977, 43, 9974, 28194, 1930, 7042, 7163, 7883, 18, 2176, 1977, 7067, 4958, 23958, 2037, 4876, 1019, 3]}]}
{"query": {"id": "q_4925", "content": "PG [SEP] PURPOSE: NGF and PGs in the bladder can be affected by pathological changes in the ", "tokenized_content": [2, 5306, 3, 5120, 30, 13741, 1930, 22571, 1922, 1920, 7821, 2112, 1998, 4218, 2007, 6598, 2840, 1922, 1920, 3]}, "items": [{"id": "p_4925", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_4926", "content": "low back pain [SEP] Acute low back pain during intravenous administration of amiodarone: a report of tw", "tokenized_content": [2, 2330, 3231, 3594, 3, 3939, 2330, 3231, 3594, 2409, 7307, 4183, 1927, 15665, 25033, 2830, 1021, 30, 43, 3809, 1927, 2249, 3]}, "items": [{"id": "p_4926", "content": "Low Back Pain [SEP] Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INT", "score": 1, "type": null, "tokenized_content": [2, 2330, 3231, 3594, 3, 3939, 2014, 3724, 3594, 1922, 1920, 10781, 2014, 27041, 3451, 16, 2154, 2278, 1998, 2458, 1956, 25795, 1037, 17, 13749, 2080, 6039, 2617, 1930, 4046, 31, 2218, 3]}]}
{"query": {"id": "q_4927", "content": "amiodarone [SEP] Acute low back pain during intravenous administration of amiodarone: a report of two cases.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 3939, 2330, 3231, 3594, 2409, 7307, 4183, 1927, 15665, 25033, 2830, 1021, 30, 43, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_4927", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_4928", "content": "Amiodarone [SEP] Amiodarone represents an effective antiarrhythmic drug for cardioversion o", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 15665, 25033, 2830, 1021, 4972, 1925, 3655, 2246, 23246, 4913, 2838, 1958, 21129, 12076, 57, 3]}, "items": [{"id": "p_4928", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_4929", "content": "atrial fibrillation [SEP] effective antiarrhythmic drug for cardioversion of recent-onset atrial fibrillation (AF) and maintenance of sinus rhythm. We briefly describe two p", "tokenized_content": [2, 9224, 13671, 3, 3655, 2246, 23246, 4913, 2838, 1958, 21129, 12076, 1927, 3505, 17, 4727, 9224, 13671, 12, 2221, 13, 1930, 6291, 1927, 9414, 11529, 18, 2038, 6699, 5993, 2288, 3]}, "items": [{"id": "p_4929", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_4930", "content": "AF [SEP] mic drug for cardioversion of recent-onset atrial fibrillation (AF) and maintenance of sinus rhythm. We briefly describe two patie", "tokenized_content": [2, 2221, 3, 2206, 2838, 1958, 21129, 12076, 1927, 3505, 17, 4727, 9224, 13671, 12, 2221, 13, 1930, 6291, 1927, 9414, 11529, 18, 2038, 6699, 5993, 2288, 2091, 1021, 3]}, "items": [{"id": "p_4930", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_4931", "content": "low back pain [SEP] onset atrial fibrillation, who experienced an acute devastating low back pain a few minutes after initiation of intravenous amiodarone loadin", "tokenized_content": [2, 2330, 3231, 3594, 3, 4727, 9224, 13671, 16, 2746, 6090, 1925, 3939, 23117, 2330, 3231, 3594, 43, 3855, 4814, 2256, 6035, 1927, 7307, 15665, 25033, 2830, 1021, 4019, 1921, 3]}, "items": [{"id": "p_4931", "content": "Low Back Pain [SEP] Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INT", "score": 1, "type": null, "tokenized_content": [2, 2330, 3231, 3594, 3, 3939, 2014, 3724, 3594, 1922, 1920, 10781, 2014, 27041, 3451, 16, 2154, 2278, 1998, 2458, 1956, 25795, 1037, 17, 13749, 2080, 6039, 2617, 1930, 4046, 31, 2218, 3]}]}
{"query": {"id": "q_4932", "content": "amiodarone [SEP] ing low back pain a few minutes after initiation of intravenous amiodarone loading. Notably, this side effect has not been ever reported i", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 30393, 2330, 3231, 3594, 43, 3855, 4814, 2256, 6035, 1927, 7307, 15665, 25033, 2830, 1021, 6693, 18, 7388, 16, 2052, 4159, 2495, 2258, 2084, 2252, 3]}, "items": [{"id": "p_4932", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_4933", "content": "Postoperative myalgia [SEP] Postoperative myalgia after succinylcholine: no evidence for an inflammatory origin.", "tokenized_content": [2, 5924, 3057, 20394, 2126, 3, 5924, 3057, 20394, 2126, 2256, 13791, 2199, 11603, 30, 2239, 3095, 1958, 1925, 3769, 4853, 18, 3]}, "items": [{"id": "p_4933", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_4934", "content": "succinylcholine [SEP] Postoperative myalgia after succinylcholine: no evidence for an inflammatory origin.", "tokenized_content": [2, 13791, 2199, 11603, 3, 5924, 3057, 20394, 2126, 2256, 13791, 2199, 11603, 30, 2239, 3095, 1958, 1925, 3769, 4853, 18, 3]}, "items": [{"id": "p_4934", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_4935", "content": "succinylcholine [SEP] A common side effect associated with succinylcholine is postoperative myalgia. The pathogenesis of this myalgia is s", "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 3059, 4159, 2495, 2458, 1956, 13791, 2199, 11603, 1977, 5924, 3057, 20394, 2126, 18, 1920, 6559, 1927, 2052, 3057, 20394, 2126, 1977, 61, 3]}, "items": [{"id": "p_4935", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_4936", "content": "postoperative myalgia [SEP] A common side effect associated with succinylcholine is postoperative myalgia. The pathogenesis of this myalgia is still unclear; inflammatio", "tokenized_content": [2, 5924, 3057, 20394, 2126, 3, 43, 3059, 4159, 2495, 2458, 1956, 13791, 2199, 11603, 1977, 5924, 3057, 20394, 2126, 18, 1920, 6559, 1927, 2052, 3057, 20394, 2126, 1977, 3974, 6390, 3]}, "items": [{"id": "p_4936", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_4937", "content": "myalgia [SEP] on side effect associated with succinylcholine is postoperative myalgia. The pathogenesis of this myalgia is still unclear; inflammatio", "tokenized_content": [2, 3057, 20394, 2126, 3, 1990, 4159, 2495, 2458, 1956, 13791, 2199, 11603, 1977, 5924, 3057, 20394, 2126, 18, 1920, 6559, 1927, 2052, 3057, 20394, 2126, 1977, 3974, 6390, 31, 3121, 3]}, "items": [{"id": "p_4937", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_4938", "content": "inflammation [SEP] ive myalgia. The pathogenesis of this myalgia is still unclear; inflammation has been suggested but without convincing evidence. We designed", "tokenized_content": [2, 4531, 3, 4370, 1021, 3057, 20394, 2126, 18, 1920, 6559, 1927, 2052, 3057, 20394, 2126, 1977, 3974, 6390, 31, 4531, 2258, 2252, 3978, 2308, 2979, 23190, 3095, 18, 2038, 4609, 3]}, "items": [{"id": "p_4938", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_4939", "content": "dexamethasone [SEP] myalgia was determined in 64 patients pretreated with saline or dexamethasone before succinylcholine (n = 32 for each). Incidence and severit", "tokenized_content": [2, 12681, 3, 3057, 20394, 2126, 1982, 3180, 1922, 4723, 2132, 12152, 1956, 5977, 2014, 12681, 3119, 13791, 2199, 11603, 12, 56, 33, 3323, 1958, 2362, 13, 18, 4332, 1930, 2757, 3]}, "items": [{"id": "p_4939", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4940", "content": "Levodopa [SEP] Levodopa-induced oromandibular dystonia in progressive supranuclear pals", "tokenized_content": [2, 26723, 3, 26723, 17, 2719, 25027, 22580, 12380, 23357, 1922, 7529, 21038, 1022, 13821, 16834, 3]}, "items": [{"id": "p_4940", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4941", "content": "dystonia [SEP] Levodopa-induced oromandibular dystonia in progressive supranuclear palsy.", "tokenized_content": [2, 23357, 3, 26723, 17, 2719, 25027, 22580, 12380, 23357, 1922, 7529, 21038, 1022, 13821, 18698, 18, 3]}, "items": [{"id": "p_4941", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_4942", "content": "progressive supranuclear palsy [SEP] Levodopa-induced oromandibular dystonia in progressive supranuclear palsy.", "tokenized_content": [2, 7529, 21038, 1022, 13821, 18698, 3, 26723, 17, 2719, 25027, 22580, 12380, 23357, 1922, 7529, 21038, 1022, 13821, 18698, 18, 3]}, "items": [{"id": "p_4942", "content": "Supranuclear Palsy, Progressive [SEP] A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranucl", "score": 1, "type": null, "tokenized_content": [2, 21038, 1022, 13821, 18698, 16, 7529, 3, 43, 15676, 2573, 1927, 1920, 4101, 7580, 2433, 4378, 2007, 6766, 9097, 31, 10046, 9254, 4414, 12, 21038, 1022, 14138, 3]}]}
{"query": {"id": "q_4943", "content": "Levodopa [SEP] Levodopa-induced dyskinesias have been reported in Parkinson's disease a", "tokenized_content": [2, 26723, 3, 26723, 17, 2719, 3890, 26682, 1036, 2162, 2252, 2568, 1922, 10124, 11, 61, 2573, 43, 3]}, "items": [{"id": "p_4943", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4944", "content": "dyskinesias [SEP] Levodopa-induced dyskinesias have been reported in Parkinson's disease and multiple system a", "tokenized_content": [2, 3890, 26682, 1036, 3, 26723, 17, 2719, 3890, 26682, 1036, 2162, 2252, 2568, 1922, 10124, 11, 61, 2573, 1930, 3137, 2433, 43, 3]}, "items": [{"id": "p_4944", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4945", "content": "Parkinson's disease [SEP] Levodopa-induced dyskinesias have been reported in Parkinson's disease and multiple system atrophy. Cranial dystonias are rare in pati", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 26723, 17, 2719, 3890, 26682, 1036, 2162, 2252, 2568, 1922, 10124, 11, 61, 2573, 1930, 3137, 2433, 10260, 18, 13598, 23357, 1036, 2032, 5844, 1922, 3]}, "items": [{"id": "p_4945", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4946", "content": "multiple system atrophy [SEP] duced dyskinesias have been reported in Parkinson's disease and multiple system atrophy. Cranial dystonias are rare in patients with progressive supran", "tokenized_content": [2, 3137, 2433, 10260, 3, 10677, 1919, 3890, 26682, 1036, 2162, 2252, 2568, 1922, 10124, 11, 61, 2573, 1930, 3137, 2433, 10260, 18, 13598, 23357, 1036, 2032, 5844, 1922, 2132, 1956, 3]}, "items": [{"id": "p_4946", "content": "Multiple System Atrophy [SEP] A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEG", "score": 1, "type": null, "tokenized_content": [2, 3137, 2433, 10260, 3, 43, 4741, 2796, 7179, 1927, 2559, 2961, 2154, 3015, 2535, 4936, 1927, 1920, 2841, 2573, 2585, 30, 8488, 13339, 2299, 1923, 3744, 3]}]}
{"query": {"id": "q_4947", "content": "dystonias [SEP] ted in Parkinson's disease and multiple system atrophy. Cranial dystonias are rare in patients with progressive supranuclear palsy (PSP).", "tokenized_content": [2, 23357, 1036, 3, 26080, 1922, 10124, 11, 61, 2573, 1930, 3137, 2433, 10260, 18, 13598, 23357, 1036, 2032, 5844, 1922, 2132, 1956, 7529, 21038, 1022, 13821, 18698, 12, 19100, 13, 3]}, "items": [{"id": "p_4947", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_4948", "content": "progressive supranuclear palsy [SEP] ple system atrophy. Cranial dystonias are rare in patients with progressive supranuclear palsy (PSP). In this report we describe an unusual case of reversible", "tokenized_content": [2, 7529, 21038, 1022, 13821, 18698, 3, 6483, 2433, 10260, 18, 13598, 23357, 1036, 2032, 5844, 1922, 2132, 1956, 7529, 21038, 1022, 13821, 18698, 12, 19100, 13, 18, 1922, 2052, 3809, 3]}, "items": [{"id": "p_4948", "content": "Supranuclear Palsy, Progressive [SEP] A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranucl", "score": 1, "type": null, "tokenized_content": [2, 21038, 1022, 13821, 18698, 16, 7529, 3, 43, 15676, 2573, 1927, 1920, 4101, 7580, 2433, 4378, 2007, 6766, 9097, 31, 10046, 9254, 4414, 12, 21038, 1022, 14138, 3]}]}
{"query": {"id": "q_4949", "content": "PSP [SEP] onias are rare in patients with progressive supranuclear palsy (PSP). In this report we describe an unusual case of reversible levo", "tokenized_content": [2, 19100, 3, 1990, 10657, 2032, 5844, 1922, 2132, 1956, 7529, 21038, 1022, 13821, 18698, 12, 19100, 13, 18, 1922, 2052, 3809, 2038, 5993, 1925, 12236, 3087, 1927, 10743, 30129, 3]}, "items": [{"id": "p_4949", "content": "Supranuclear Palsy, Progressive [SEP] A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranucl", "score": 1, "type": null, "tokenized_content": [2, 21038, 1022, 13821, 18698, 16, 7529, 3, 43, 15676, 2573, 1927, 1920, 4101, 7580, 2433, 4378, 2007, 6766, 9097, 31, 10046, 9254, 4414, 12, 21038, 1022, 14138, 3]}]}
{"query": {"id": "q_4950", "content": "levodopa [SEP] (PSP). In this report we describe an unusual case of reversible levodopa-induced Oromandibular dystonia (OMD) in a PSP patient to highli", "tokenized_content": [2, 26723, 3, 12, 19100, 13, 18, 1922, 2052, 3809, 2038, 5993, 1925, 12236, 3087, 1927, 10743, 26723, 17, 2719, 25027, 22580, 12380, 23357, 12, 7254, 1007, 13, 1922, 43, 19100, 3]}, "items": [{"id": "p_4950", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4951", "content": "Oromandibular dystonia [SEP] port we describe an unusual case of reversible levodopa-induced Oromandibular dystonia (OMD) in a PSP patient to highlight the importance of recognizi", "tokenized_content": [2, 25027, 22580, 12380, 23357, 3, 9260, 2038, 5993, 1925, 12236, 3087, 1927, 10743, 26723, 17, 2719, 25027, 22580, 12380, 23357, 12, 7254, 1007, 13, 1922, 43, 19100, 2774, 1942, 9159, 3]}, "items": [{"id": "p_4951", "content": "Meige Syndrome [SEP] A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle s", "score": 1, "type": null, "tokenized_content": [2, 29399, 2106, 4741, 3, 43, 4741, 4378, 2007, 25027, 18703, 23357, 31, 2710, 6189, 4151, 5424, 2691, 31, 5495, 2903, 16795, 9497, 31, 3178, 20629, 31, 4474, 28931, 1019, 3760, 61, 3]}]}
{"query": {"id": "q_4952", "content": "OMD [SEP] ual case of reversible levodopa-induced Oromandibular dystonia (OMD) in a PSP patient to highlight the importance of recognizing th", "tokenized_content": [2, 7254, 1007, 3, 17942, 1024, 3087, 1927, 10743, 26723, 17, 2719, 25027, 22580, 12380, 23357, 12, 7254, 1007, 13, 1922, 43, 19100, 2774, 1942, 9159, 1920, 4737, 1927, 15667, 1913, 3]}, "items": [{"id": "p_4952", "content": "Meige Syndrome [SEP] A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle s", "score": 1, "type": null, "tokenized_content": [2, 29399, 2106, 4741, 3, 43, 4741, 4378, 2007, 25027, 18703, 23357, 31, 2710, 6189, 4151, 5424, 2691, 31, 5495, 2903, 16795, 9497, 31, 3178, 20629, 31, 4474, 28931, 1019, 3760, 61, 3]}]}
{"query": {"id": "q_4953", "content": "edaravone [SEP] Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pi", "tokenized_content": [2, 3347, 9041, 15525, 2912, 3, 6337, 2495, 1927, 3347, 9041, 15525, 2912, 3316, 10666, 17, 2719, 14008, 1944, 11930, 1922, 1920, 12938, 4269, 3]}, "items": [{"id": "p_4953", "content": "phenylmethylpyrazolone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29017, 18425, 10457, 2290, 3, 3]}]}
{"query": {"id": "q_4954", "content": "streptomycin [SEP] Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.", "tokenized_content": [2, 10666, 3, 6337, 2495, 1927, 3347, 9041, 15525, 2912, 3316, 10666, 17, 2719, 14008, 1944, 11930, 1922, 1920, 12938, 5445, 18, 3]}, "items": [{"id": "p_4954", "content": "Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces", "score": 1, "type": null, "tokenized_content": [2, 10666, 3, 1925, 7267, 4152, 2007, 1920, 6072, 4718, 13386, 11555, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 1920, 6035, 1930, 9971, 9803, 1036, 3]}]}
{"query": {"id": "q_4955", "content": "vestibulotoxicity [SEP] Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.", "tokenized_content": [2, 14008, 1944, 11930, 3, 6337, 2495, 1927, 3347, 9041, 15525, 2912, 3316, 10666, 17, 2719, 14008, 1944, 11930, 1922, 1920, 12938, 5445, 18, 3]}, "items": [{"id": "p_4955", "content": "Vestibular Diseases [SEP] Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular dise", "score": 1, "type": null, "tokenized_content": [2, 15752, 3902, 3, 6598, 4028, 1927, 1920, 15752, 2857, 13133, 1963, 2154, 5461, 3131, 1927, 1920, 22373, 11161, 18, 2132, 1956, 15752, 2445, 3]}]}
{"query": {"id": "q_4956", "content": "streptomycin [SEP] This study investigated alleviation of streptomycin-induced vestibulotoxicity by edaravone in guinea pigs. Edaravon", "tokenized_content": [2, 10666, 3, 2052, 2161, 3845, 12054, 1943, 1927, 10666, 17, 2719, 14008, 1944, 11930, 2007, 3347, 9041, 15525, 2912, 1922, 12938, 9586, 18, 3347, 9041, 15525, 1022, 3]}, "items": [{"id": "p_4956", "content": "Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces", "score": 1, "type": null, "tokenized_content": [2, 10666, 3, 1925, 7267, 4152, 2007, 1920, 6072, 4718, 13386, 11555, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 1920, 6035, 1930, 9971, 9803, 1036, 3]}]}
{"query": {"id": "q_4957", "content": "vestibulotoxicity [SEP] This study investigated alleviation of streptomycin-induced vestibulotoxicity by edaravone in guinea pigs. Edaravone, a free radical scavenge", "tokenized_content": [2, 14008, 1944, 11930, 3, 2052, 2161, 3845, 12054, 1943, 1927, 10666, 17, 2719, 14008, 1944, 11930, 2007, 3347, 9041, 15525, 2912, 1922, 12938, 9586, 18, 3347, 9041, 15525, 2912, 16, 3]}, "items": [{"id": "p_4957", "content": "Vestibular Diseases [SEP] Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular dise", "score": 1, "type": null, "tokenized_content": [2, 15752, 3902, 3, 6598, 4028, 1927, 1920, 15752, 2857, 13133, 1963, 2154, 5461, 3131, 1927, 1920, 22373, 11161, 18, 2132, 1956, 15752, 2445, 3]}]}
{"query": {"id": "q_4958", "content": "edaravone [SEP] igated alleviation of streptomycin-induced vestibulotoxicity by edaravone in guinea pigs. Edaravone, a free radical scavenger, has potent", "tokenized_content": [2, 3347, 9041, 15525, 2912, 3, 12114, 2013, 12054, 1943, 1927, 10666, 17, 2719, 14008, 1944, 11930, 2007, 3347, 9041, 15525, 2912, 1922, 12938, 9586, 18, 3347, 9041, 15525, 2912, 16, 3]}, "items": [{"id": "p_4958", "content": "phenylmethylpyrazolone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29017, 18425, 10457, 2290, 3, 3]}]}
{"query": {"id": "q_4959", "content": "Edaravone [SEP] ptomycin-induced vestibulotoxicity by edaravone in guinea pigs. Edaravone, a free radical scavenger, has potent free radical quenching ac", "tokenized_content": [2, 3347, 9041, 15525, 2912, 3, 4401, 7928, 17, 2719, 14008, 1944, 11930, 2007, 3347, 9041, 15525, 2912, 1922, 12938, 9586, 18, 3347, 9041, 15525, 2912, 16, 43, 3294, 6917, 21433, 3]}, "items": [{"id": "p_4959", "content": "phenylmethylpyrazolone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29017, 18425, 10457, 2290, 3, 3]}]}
{"query": {"id": "q_4960", "content": "cerebral infarction [SEP] ical quenching action and is used in clinical practice to treat cerebral infarction. Streptomycin was administered to the inner ear by osmotic pump", "tokenized_content": [2, 6329, 8358, 3, 14784, 1024, 16721, 4615, 1930, 1977, 2251, 1922, 2535, 4695, 1942, 2297, 6329, 8358, 18, 10666, 1982, 5254, 1942, 1920, 6671, 4352, 2007, 13951, 8912, 3]}, "items": [{"id": "p_4960", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_4961", "content": "Streptomycin [SEP]  and is used in clinical practice to treat cerebral infarction. Streptomycin was administered to the inner ear by osmotic pump for 24 h, and", "tokenized_content": [2, 10666, 3, 1930, 1977, 2251, 1922, 2535, 4695, 1942, 2297, 6329, 8358, 18, 10666, 1982, 5254, 1942, 1920, 6671, 4352, 2007, 13951, 8912, 1958, 2686, 50, 16, 1930, 3]}, "items": [{"id": "p_4961", "content": "Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces", "score": 1, "type": null, "tokenized_content": [2, 10666, 3, 1925, 7267, 4152, 2007, 1920, 6072, 4718, 13386, 11555, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 1920, 6035, 1930, 9971, 9803, 1036, 3]}]}
{"query": {"id": "q_4962", "content": "Ketamine [SEP] Ketamine in war/tropical surgery (a final tribute to the racemic mixture", "tokenized_content": [2, 14049, 3, 14049, 1922, 8200, 19, 12862, 3782, 12, 43, 3948, 14521, 2696, 1942, 1920, 7442, 4913, 5515, 3]}, "items": [{"id": "p_4962", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_4963", "content": "ketamine [SEP] A technique of continuous intravenous anaesthesia with ketamine was used successfully during the Somalia civil war in 1994 and ", "tokenized_content": [2, 14049, 3, 43, 4778, 1927, 4798, 7307, 17107, 1956, 14049, 1982, 2251, 6664, 2409, 1920, 18078, 12191, 1019, 20073, 8200, 1922, 7319, 1930, 3]}, "items": [{"id": "p_4963", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_4964", "content": "oxygen [SEP] entilators in patients on spontaneous ventilation breathing air/oxygen only. After premedication with diazepam, glycopyrrolate and loc", "tokenized_content": [2, 4612, 3, 5080, 5148, 3448, 1922, 2132, 1990, 6242, 10198, 11995, 4433, 19, 4612, 2444, 18, 2256, 6546, 8943, 1943, 1956, 26079, 16, 8821, 3553, 2226, 2010, 1930, 2536, 3]}, "items": [{"id": "p_4964", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_4965", "content": "diazepam [SEP] ventilation breathing air/oxygen only. After premedication with diazepam, glycopyrrolate and local anaesthesia, and induction with stand", "tokenized_content": [2, 26079, 3, 10198, 11995, 4433, 19, 4612, 2444, 18, 2256, 6546, 8943, 1943, 1956, 26079, 16, 8821, 3553, 2226, 2010, 1930, 3076, 17107, 16, 1930, 4408, 1956, 2924, 3]}, "items": [{"id": "p_4965", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_4966", "content": "glycopyrrolate [SEP] n breathing air/oxygen only. After premedication with diazepam, glycopyrrolate and local anaesthesia, and induction with standard doses of ket", "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 56, 11995, 4433, 19, 4612, 2444, 18, 2256, 6546, 8943, 1943, 1956, 26079, 16, 8821, 3553, 2226, 2010, 1930, 3076, 17107, 16, 1930, 4408, 1956, 3]}, "items": [{"id": "p_4966", "content": "Glycopyrrolate [SEP] A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with", "score": 1, "type": null, "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 43, 20318, 8151, 2251, 1966, 1925, 8059, 4302, 18538, 12486, 16, 1922, 2673, 4414, 1927, 1920, 8375, 6482, 16, 1930, 1942, 4412, 12999, 1929, 1956, 3]}]}
{"query": {"id": "q_4967", "content": "Diazepam [SEP] bedside clinical monitoring, relying heavily on the heart rate. Diazepam, unless contraindicated or risky, remains the only necessary co", "tokenized_content": [2, 26079, 3, 23579, 2535, 5378, 16, 21119, 14231, 1990, 1920, 4003, 2769, 18, 26079, 16, 10292, 17825, 22171, 2014, 17614, 16, 4497, 1920, 2444, 4680, 2081, 3]}, "items": [{"id": "p_4967", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_4968", "content": "hallucinations [SEP] eases the duration and intensity of operative and postoperative hallucinations. Local anaesthetic blocks were useful in decreasing the require", "tokenized_content": [2, 27013, 3, 13832, 1036, 1920, 4392, 1930, 4266, 1927, 8116, 1930, 5924, 27013, 18, 3076, 28818, 7644, 1985, 4707, 1922, 7742, 1920, 4350, 3]}, "items": [{"id": "p_4968", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_4969", "content": "analgesia [SEP] cks were useful in decreasing the requirement for postoperative analgesia. An antisialogue was usually unnecessary in operations lasting ", "tokenized_content": [2, 14695, 3, 6394, 1036, 1985, 4707, 1922, 7742, 1920, 8853, 1958, 5924, 14695, 18, 1925, 8059, 2086, 2021, 2182, 1982, 5394, 16465, 1922, 11719, 11671, 3]}, "items": [{"id": "p_4969", "content": "Pain Insensitivity, Congenital [SEP] A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent cor", "score": 1, "type": null, "tokenized_content": [2, 3594, 30055, 16, 9901, 3, 43, 4741, 4378, 2007, 2063, 11307, 2055, 1942, 3594, 4281, 1920, 3682, 1942, 7279, 24218, 2037, 2447, 17, 24218, 5458, 18, 7685, 2233, 3]}]}
{"query": {"id": "q_4970", "content": "Steroid [SEP] Steroid structure and pharmacological properties determine the anti-amn", "tokenized_content": [2, 9507, 3, 9507, 3170, 1930, 7683, 3879, 3415, 1920, 2246, 17, 14701, 3]}, "items": [{"id": "p_4970", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4971", "content": "amnesic [SEP] oid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task ", "tokenized_content": [2, 14701, 18522, 1030, 3, 25166, 1007, 3170, 1930, 7683, 3879, 3415, 1920, 2246, 17, 14701, 18522, 1030, 2564, 1927, 4297, 9356, 2290, 20415, 1922, 1920, 9832, 11700, 3909, 3]}, "items": [{"id": "p_4971", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_4972", "content": "pregnenolone sulphate [SEP] harmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.", "tokenized_content": [2, 4297, 9356, 2290, 20415, 3, 7613, 20682, 22284, 2046, 3879, 3415, 1920, 2246, 17, 14701, 18522, 1030, 2564, 1927, 4297, 9356, 2290, 20415, 1922, 1920, 9832, 11700, 3909, 1922, 3615, 3]}, "items": [{"id": "p_4972", "content": "pregnenolone sulfate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4297, 9356, 2290, 8767, 3, 3]}]}
{"query": {"id": "q_4973", "content": "Pregnenolone sulphate [SEP] Pregnenolone sulphate (PREGS) has generated interest as one of the most potent memory", "tokenized_content": [2, 4297, 9356, 2290, 20415, 3, 4297, 9356, 2290, 20415, 12, 26424, 1036, 13, 2258, 3999, 4501, 1966, 2340, 1927, 1920, 2501, 6828, 4525, 3]}, "items": [{"id": "p_4973", "content": "pregnenolone sulfate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4297, 9356, 2290, 8767, 3, 3]}]}
{"query": {"id": "q_4974", "content": "PREGS [SEP] Pregnenolone sulphate (PREGS) has generated interest as one of the most potent memory-enhanc", "tokenized_content": [2, 26424, 1036, 3, 4297, 9356, 2290, 20415, 12, 26424, 1036, 13, 2258, 3999, 4501, 1966, 2340, 1927, 1920, 2501, 6828, 4525, 17, 3102, 2412, 3]}, "items": [{"id": "p_4974", "content": "pregnenolone sulfate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4297, 9356, 2290, 8767, 3, 3]}]}
{"query": {"id": "q_4975", "content": "steroid [SEP] erated interest as one of the most potent memory-enhancing neurosteroids to be examined in rodent learning studies, with particular imp", "tokenized_content": [2, 9507, 3, 14821, 2013, 4501, 1966, 2340, 1927, 1920, 2501, 6828, 4525, 17, 9221, 7318, 1967, 4929, 1942, 1998, 3572, 1922, 11880, 4809, 2351, 16, 1956, 3278, 2754, 3]}, "items": [{"id": "p_4975", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4976", "content": "N-methyl-d-aspartate [SEP] tems from findings that PREGS is a potent positive modulator of N-methyl-d-aspartate receptors (NMDARs) and a negative modulator of gamma-aminobutyr", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 2775, 1036, 2037, 3056, 1988, 26424, 1036, 1977, 43, 6828, 2843, 18521, 1927, 56, 17, 4963, 17, 46, 17, 12878, 4086, 12, 3]}, "items": [{"id": "p_4976", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_4977", "content": "gamma-aminobutyric acid [SEP] thyl-d-aspartate receptors (NMDARs) and a negative modulator of gamma-aminobutyric acid(A) receptors (GABA(A)Rs). Moreover, PREGS is able to reverse th", "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 30193, 17, 46, 17, 12878, 4086, 12, 28620, 13, 1930, 43, 3136, 18521, 1927, 7034, 17, 29093, 2687, 12, 43, 13, 4086, 12, 7992, 12, 3]}, "items": [{"id": "p_4977", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4978", "content": "GABA [SEP] rmation is hypothesized to involve actions on glutamatergic and GABAergic systems. This hypothesis stems from findings that PREGS is", "tokenized_content": [2, 7992, 3, 10625, 1943, 1977, 7149, 1942, 8156, 7728, 1990, 16922, 1930, 14468, 3771, 18, 2052, 4676, 16096, 2037, 3056, 1988, 26424, 1036, 1977, 3]}, "items": [{"id": "p_4978", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4979", "content": "amnesic [SEP] ) receptors (GABA(A)Rs). Moreover, PREGS is able to reverse the amnesic-like effects of NMDAR and GABA(A)R ligands. To investigate this", "tokenized_content": [2, 14701, 18522, 1030, 3, 13, 4086, 12, 7992, 12, 43, 13, 4366, 13, 18, 3950, 16, 26424, 1036, 1977, 4236, 1942, 5267, 1920, 14701, 18522, 1030, 17, 3189, 2564, 1927, 3]}, "items": [{"id": "p_4979", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_4980", "content": "epipregnanolone ([3beta-hydroxy-5beta-pregnan-20-one] sulphate [SEP] e sulphate (an agent that is inactive at GABA(A)Rs and NMDARs), epipregnanolone ([3beta-hydroxy-5beta-pregnan-20-one] sulphate, an inhibitor of both GABA(A)Rs and NMDARs), and a newly synthe", "tokenized_content": [2, 13872, 4060, 3223, 4296, 2290, 12, 37, 6341, 9215, 17, 8275, 17, 7807, 9215, 17, 4297, 1928, 17, 2036, 17, 2340, 39, 20415, 3, 47, 20415, 12, 1925, 5899, 1988, 3]}, "items": [{"id": "p_4980", "content": "pregnenolone sulfate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4297, 9356, 2290, 8767, 3, 3]}]}
{"query": {"id": "q_4981", "content": "scopolamine [SEP] gs were tested in the passive avoidance task using the model of scopolamine-induced amnesia. Both PREGS and its (-) enantiomer blocked the ", "tokenized_content": [2, 25392, 10173, 25157, 3, 5022, 1985, 3620, 1922, 1920, 9832, 11700, 3909, 2193, 1920, 2322, 1927, 25392, 10173, 25157, 17, 2719, 14701, 7156, 18, 2321, 26424, 1036, 1930, 2496, 12, 3]}, "items": [{"id": "p_4981", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4982", "content": "amnesia [SEP] e passive avoidance task using the model of scopolamine-induced amnesia. Both PREGS and its (-) enantiomer blocked the effects of scopo", "tokenized_content": [2, 14701, 7156, 3, 47, 9832, 11700, 3909, 2193, 1920, 2322, 1927, 25392, 10173, 25157, 17, 2719, 14701, 7156, 18, 2321, 26424, 1036, 1930, 2496, 12, 17, 13, 30027, 6923, 1920, 3]}, "items": [{"id": "p_4982", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_4983", "content": "epipregnanolone sulphate [SEP] sults show that, unlike PREGS, 11-ketopregnenolone sulphate and epipregnanolone sulphate failed to block the effect of scopolamine, suggesting that alte", "tokenized_content": [2, 13872, 4060, 3223, 4296, 2290, 20415, 3, 9596, 1973, 2146, 1988, 16, 7945, 26424, 1036, 16, 2513, 17, 21471, 4060, 3223, 9356, 2290, 20415, 1930, 13872, 4060, 3223, 4296, 2290, 3]}, "items": [{"id": "p_4983", "content": "pregnenolone sulfate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4297, 9356, 2290, 8767, 3, 3]}]}
{"query": {"id": "q_4984", "content": "NMDA [SEP]  a potent positive modulator of N-methyl-d-aspartate receptors (NMDARs) and a negative modulator of gamma-aminobutyric acid(A) recep", "tokenized_content": [2, 10976, 3, 43, 6828, 2843, 18521, 1927, 56, 17, 4963, 17, 46, 17, 12878, 4086, 12, 28620, 13, 1930, 43, 3136, 18521, 1927, 7034, 17, 29093, 2687, 12, 43, 13, 3]}, "items": [{"id": "p_4984", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_4985", "content": "steroids [SEP] erated interest as one of the most potent memory-enhancing neurosteroids to be examined in rodent learning studies, with particular impo", "tokenized_content": [2, 13039, 3, 14821, 2013, 4501, 1966, 2340, 1927, 1920, 2501, 6828, 4525, 17, 9221, 7318, 1967, 4929, 1942, 1998, 3572, 1922, 11880, 4809, 2351, 16, 1956, 3278, 2754, 1037, 3]}, "items": [{"id": "p_4985", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4986", "content": "adenosine [SEP] sessment of intrathecal injection of an American formulation of adenosine in humans.", "tokenized_content": [2, 10125, 3, 9924, 18538, 1939, 1927, 22782, 4107, 1927, 1925, 5339, 10126, 1927, 10125, 1922, 5209, 18, 3]}, "items": [{"id": "p_4986", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_4987", "content": "adenosine [SEP] BACKGROUND: Preclinical studies of intrathecal adenosine suggest it may be effective in the treatment of acute and chron", "tokenized_content": [2, 10125, 3, 3872, 30, 10311, 2351, 1927, 22782, 10125, 3220, 2176, 2278, 1998, 3655, 1922, 1920, 2311, 1927, 3939, 1930, 3589, 3]}, "items": [{"id": "p_4987", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_4988", "content": "chronic pain [SEP] osine suggest it may be effective in the treatment of acute and chronic pain in humans, and preliminary studies in volunteers and patients w", "tokenized_content": [2, 3724, 3594, 3, 3125, 2053, 3220, 2176, 2278, 1998, 3655, 1922, 1920, 2311, 1927, 3939, 1930, 3724, 3594, 1922, 5209, 16, 1930, 8458, 2351, 1922, 9701, 1930, 2132, 65, 3]}, "items": [{"id": "p_4988", "content": "Chronic Pain [SEP] Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persi", "score": 1, "type": null, "tokenized_content": [2, 3724, 3594, 3, 3546, 1941, 15826, 1988, 20350, 1958, 2253, 2254, 43, 3855, 3221, 18, 2176, 2278, 2014, 2278, 2084, 1998, 2458, 1956, 7176, 2014, 2573, 16, 1930, 2278, 3096, 1033, 3]}]}
{"query": {"id": "q_4989", "content": "hypersensitivity [SEP] wedish formulation of adenosine suggests it may be effective in hypersensitivity states but not with acute noxious stimulation. The purpose of t", "tokenized_content": [2, 14625, 3, 17801, 2471, 10126, 1927, 10125, 4015, 2176, 2278, 1998, 3655, 1922, 14625, 4376, 2308, 2084, 1956, 3939, 24218, 4177, 18, 1920, 5120, 1927, 62, 3]}, "items": [{"id": "p_4989", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_4990", "content": "capsaicin [SEP] ne marketed in the US, using both acute noxious stimulation and capsaicin-evoked mechanical hypersensitivity. METHODS: Following Food and", "tokenized_content": [2, 19156, 3, 2069, 28392, 1922, 1920, 2022, 16, 2193, 2321, 3939, 24218, 4177, 1930, 19156, 17, 8782, 5821, 14625, 18, 2860, 30, 2894, 3959, 1930, 3]}, "items": [{"id": "p_4990", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_4991", "content": "pain [SEP] ggest it may be effective in the treatment of acute and chronic pain in humans, and preliminary studies in volunteers and patients w", "tokenized_content": [2, 3594, 3, 12358, 2158, 2176, 2278, 1998, 3655, 1922, 1920, 2311, 1927, 3939, 1930, 3724, 3594, 1922, 5209, 16, 1930, 8458, 2351, 1922, 9701, 1930, 2132, 65, 3]}, "items": [{"id": "p_4991", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4992", "content": "mechanical hyperalgesia [SEP] and pain ratings in response to acute heat stimuli and areas of mechanical hyperalgesia and allodynia after intradermal capsaicin injection were determ", "tokenized_content": [2, 5821, 21525, 3, 1930, 3594, 10158, 1922, 2644, 1942, 3939, 5631, 5458, 1930, 3957, 1927, 5821, 21525, 1930, 25233, 2256, 18736, 7069, 19156, 4107, 1985, 2542, 3]}, "items": [{"id": "p_4992", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4993", "content": "allodynia [SEP]  to acute heat stimuli and areas of mechanical hyperalgesia and allodynia after intradermal capsaicin injection were determined. RESULTS:", "tokenized_content": [2, 25233, 3, 1942, 3939, 5631, 5458, 1930, 3957, 1927, 5821, 21525, 1930, 25233, 2256, 18736, 7069, 19156, 4107, 1985, 3180, 18, 2274, 30, 3]}, "items": [{"id": "p_4993", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4994", "content": "Adenosine [SEP] after intradermal capsaicin injection were determined. RESULTS: Adenosine produced no effect on pain report to acute noxious thermal or c", "tokenized_content": [2, 10125, 3, 2256, 18736, 7069, 19156, 4107, 1985, 3180, 18, 2274, 30, 10125, 4152, 2239, 2495, 1990, 3594, 3809, 1942, 3939, 24218, 7111, 2014, 45, 3]}, "items": [{"id": "p_4994", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_4995", "content": "neuropathic pain [SEP] h that observed in preliminary reports of patients with chronic neuropathic pain and is not due to prolonged residence of adenosine in cerebrosp", "tokenized_content": [2, 16591, 3594, 3, 50, 1988, 2528, 1922, 8458, 4710, 1927, 2132, 1956, 3724, 16591, 3594, 1930, 1977, 2084, 2810, 1942, 7171, 13209, 1927, 10125, 1922, 15455, 3508, 3]}, "items": [{"id": "p_4995", "content": "Neuralgia [SEP] Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5181, 11966, 3, 10702, 2014, 3546, 1941, 3594, 1988, 5110, 4231, 1920, 4914, 2014, 3282, 1927, 43, 5009, 2014, 13598, 5507, 18, 3]}]}
{"query": {"id": "q_4996", "content": "lithium [SEP] Effect of lithium maintenance therapy on thyroid and parathyroid function.", "tokenized_content": [2, 14330, 3, 2495, 1927, 14330, 6291, 3181, 1990, 6918, 1930, 17152, 2347, 18, 3]}, "items": [{"id": "p_4996", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_4997", "content": "lithium [SEP] OBJECTIVES: To assess changes induced by lithium maintenance therapy on the incidence of thyroid, parathyroid an", "tokenized_content": [2, 14330, 3, 7634, 30, 1942, 2634, 2840, 2719, 2007, 14330, 6291, 3181, 1990, 1920, 4332, 1927, 6918, 16, 17152, 1925, 3]}, "items": [{"id": "p_4997", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_4998", "content": "thyroid disease [SEP] ry (whether or not the patient had a first-degree relative with thyroid disease). DESIGN: Prospective study. SETTING: Affective Disorders Clini", "tokenized_content": [2, 6918, 2573, 3, 18650, 12, 3053, 2014, 2084, 1920, 2774, 2430, 43, 2561, 17, 4647, 3338, 1956, 6918, 2573, 13, 18, 3036, 30, 6315, 2161, 18, 4308, 30, 11863, 4414, 3]}, "items": [{"id": "p_4998", "content": "Thyroid Diseases [SEP] Pathological processes involving the THYROID GLAND.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6918, 3902, 3, 6598, 4028, 5884, 1920, 6918, 8359, 18, 3]}]}
{"query": {"id": "q_4999", "content": "bipolar disorder [SEP] TIENTS: One hundred and one patients (28 men and 73 women) with bipolar disorder receiving lithium maintenance therapy ranging from 1 year's to ", "tokenized_content": [2, 10275, 4770, 3, 19108, 4905, 1036, 30, 2340, 8295, 1930, 2340, 2132, 12, 3158, 3925, 1930, 5356, 3089, 13, 1956, 10275, 4770, 5962, 14330, 6291, 3181, 6485, 2037, 21, 2476, 3]}, "items": [{"id": "p_4999", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_5000", "content": "psychiatric [SEP] s' duration. The control group consisted of 82 patients with no psychiatric or endocrinological diagnoses from the hospital's out-patient c", "tokenized_content": [2, 7652, 3, 61, 11, 4392, 18, 1920, 2285, 2210, 6994, 1927, 6175, 2132, 1956, 2239, 7652, 2014, 18851, 2477, 9455, 2037, 1920, 3461, 11, 61, 2397, 17, 2774, 45, 3]}, "items": [{"id": "p_5000", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_5001", "content": "calcium [SEP] s out-patient clinics. OUTCOME MEASURES: Laboratory analyses of calcium, magnesium and thyroid-stimulating hormone levels performed bef", "tokenized_content": [2, 5016, 3, 61, 2397, 17, 2774, 10601, 18, 3924, 3975, 30, 4542, 3247, 1927, 5016, 16, 13148, 1930, 6918, 17, 9868, 6365, 2428, 2593, 1998, 1038, 3]}, "items": [{"id": "p_5001", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_5002", "content": "magnesium [SEP] ient clinics. OUTCOME MEASURES: Laboratory analyses of calcium, magnesium and thyroid-stimulating hormone levels performed before beginni", "tokenized_content": [2, 13148, 3, 10116, 4905, 10601, 18, 3924, 3975, 30, 4542, 3247, 1927, 5016, 16, 13148, 1930, 6918, 17, 9868, 6365, 2428, 2593, 3119, 11763, 8635, 3]}, "items": [{"id": "p_5002", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_5003", "content": "Hypothyroidism [SEP] e beginning lithium therapy and at biannual follow-up. RESULTS: Hypothyroidism developed in 40 patients, excluding 8 patients who were hypothy", "tokenized_content": [2, 19316, 3, 47, 7828, 14330, 3181, 1930, 2019, 2273, 6288, 2224, 2396, 17, 2353, 18, 2274, 30, 19316, 3530, 1922, 3040, 2132, 16, 10566, 28, 2132, 2746, 1985, 3483, 1012, 3]}, "items": [{"id": "p_5003", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_5004", "content": "hypothyroid [SEP] roidism developed in 40 patients, excluding 8 patients who were hypothyroid at baseline. All patients having first-degree relatives affecte", "tokenized_content": [2, 3483, 5730, 3, 11955, 15783, 1035, 3530, 1922, 3040, 2132, 16, 10566, 28, 2132, 2746, 1985, 3483, 5730, 2019, 3703, 18, 2136, 2132, 4537, 2561, 17, 4647, 12280, 4081, 1021, 3]}, "items": [{"id": "p_5004", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_5005", "content": "thyroid illness [SEP] aseline. All patients having first-degree relatives affected by thyroid illness had accelerated onset of hypothyroidism (3.7 years after onset ", "tokenized_content": [2, 6918, 6455, 3, 28826, 3701, 18, 2136, 2132, 4537, 2561, 17, 4647, 12280, 4218, 2007, 6918, 6455, 2430, 10843, 4727, 1927, 19316, 12, 23, 18, 27, 2739, 2256, 4727, 3]}, "items": [{"id": "p_5005", "content": "Thyroid Diseases [SEP] Pathological processes involving the THYROID GLAND.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6918, 3902, 3, 6598, 4028, 5884, 1920, 6918, 8359, 18, 3]}]}
{"query": {"id": "q_5006", "content": "hypothyroidism [SEP]  relatives affected by thyroid illness had accelerated onset of hypothyroidism (3.7 years after onset of lithium therapy) compared with patien", "tokenized_content": [2, 19316, 3, 12280, 4218, 2007, 6918, 6455, 2430, 10843, 4727, 1927, 19316, 12, 23, 18, 27, 2739, 2256, 4727, 1927, 14330, 3181, 13, 2452, 1956, 2091, 1917, 3]}, "items": [{"id": "p_5006", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_5007", "content": "Magnesium [SEP] yroidism than women under 60 years of age (34.6% versus 31.9%). Magnesium levels in patients on lithium treatment were unchanged from bas", "tokenized_content": [2, 13148, 3, 13031, 2642, 2421, 2254, 3089, 2441, 3276, 2739, 1927, 2632, 12, 3540, 18, 26, 9, 4072, 3470, 18, 29, 9, 13, 18, 13148, 2428, 1922, 2132, 1990, 14330, 3]}, "items": [{"id": "p_5007", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_5008", "content": "hypercalcemia [SEP] amilial thyroid illness is a risk factor for hypothyroidism and hypercalcemia during lithium therapy.", "tokenized_content": [2, 25374, 9358, 3, 30374, 2086, 6918, 6455, 1977, 43, 2565, 2991, 1958, 19316, 1930, 25374, 9358, 2409, 14330, 3181, 18, 3]}, "items": [{"id": "p_5008", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_5009", "content": "toxicity [SEP] Systemic toxicity following administration of sirolimus (formerly rapamycin) for ", "tokenized_content": [2, 5532, 3, 5510, 5532, 2894, 4183, 1927, 4520, 24124, 12, 22397, 11100, 13, 1958, 3]}, "items": [{"id": "p_5009", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5010", "content": "sirolimus [SEP] Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary le", "tokenized_content": [2, 4520, 24124, 3, 5510, 5532, 2894, 4183, 1927, 4520, 24124, 12, 22397, 11100, 13, 1958, 14109, 30, 3279, 1927, 9623, 2071, 3]}, "items": [{"id": "p_5010", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_5011", "content": "rapamycin [SEP] stemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apo", "tokenized_content": [2, 11100, 3, 22169, 1030, 5532, 2894, 4183, 1927, 4520, 24124, 12, 22397, 11100, 13, 1958, 14109, 30, 3279, 1927, 9623, 9186, 4741, 1956, 11466, 3]}, "items": [{"id": "p_5011", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_5012", "content": "psoriasis [SEP]  following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesio", "tokenized_content": [2, 14109, 3, 2894, 4183, 1927, 4520, 24124, 12, 22397, 11100, 13, 1958, 14109, 30, 3279, 1927, 9623, 9186, 4741, 1956, 4091, 1927, 3636, 3940, 3]}, "items": [{"id": "p_5012", "content": "Psoriasis [SEP] A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches.", "score": 1, "type": null, "tokenized_content": [2, 14109, 3, 43, 3059, 9517, 3180, 16, 3724, 16, 3769, 4407, 2573, 4378, 2007, 19506, 19216, 2080, 16, 7143, 16, 12351, 12667, 18, 3]}]}
{"query": {"id": "q_5013", "content": "capillary leak syndrome [SEP] of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes.", "tokenized_content": [2, 9623, 9186, 4741, 3, 1927, 4520, 24124, 12, 22397, 11100, 13, 1958, 14109, 30, 3279, 1927, 9623, 9186, 4741, 1956, 4091, 1927, 5709, 1923, 7257, 18, 3]}, "items": [{"id": "p_5013", "content": "Capillary Leak Syndrome [SEP] A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hemat", "score": 1, "type": null, "tokenized_content": [2, 9623, 9186, 4741, 3, 43, 2625, 4378, 2007, 30489, 9232, 1927, 5466, 9186, 1941, 2037, 16973, 2460, 8324, 17, 4541, 10436, 7538, 5626, 3]}]}
{"query": {"id": "q_5014", "content": "Sirolimus [SEP] BACKGROUND: Sirolimus (formerly rapamycin) is an immunosuppressive agent that interfe", "tokenized_content": [2, 4520, 24124, 3, 3872, 30, 4520, 24124, 12, 22397, 11100, 13, 1977, 1925, 12910, 5899, 1988, 5345, 1021, 3]}, "items": [{"id": "p_5014", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_5015", "content": "rapamycin [SEP] BACKGROUND: Sirolimus (formerly rapamycin) is an immunosuppressive agent that interferes with T-cell acti", "tokenized_content": [2, 11100, 3, 3872, 30, 4520, 24124, 12, 22397, 11100, 13, 1977, 1925, 12910, 5899, 1988, 20766, 1956, 62, 17, 2024, 4033, 1033, 3]}, "items": [{"id": "p_5015", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_5016", "content": "psoriasis [SEP] hat interferes with T-cell activation. After 2 individuals with psoriasis developed a capillary leak syndrome following treatment with or", "tokenized_content": [2, 14109, 3, 16133, 20766, 1956, 62, 17, 2024, 2936, 18, 2256, 22, 3445, 1956, 14109, 3530, 43, 9623, 9186, 4741, 2894, 2311, 1956, 2014, 3]}, "items": [{"id": "p_5016", "content": "Psoriasis [SEP] A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches.", "score": 1, "type": null, "tokenized_content": [2, 14109, 3, 43, 3059, 9517, 3180, 16, 3724, 16, 3769, 4407, 2573, 4378, 2007, 19506, 19216, 2080, 16, 7143, 16, 12351, 12667, 18, 3]}]}
{"query": {"id": "q_5017", "content": "capillary leak syndrome [SEP] cell activation. After 2 individuals with psoriasis developed a capillary leak syndrome following treatment with oral sirolimus lesional skin cells and", "tokenized_content": [2, 9623, 9186, 4741, 3, 2024, 2936, 18, 2256, 22, 3445, 1956, 14109, 3530, 43, 9623, 9186, 4741, 2894, 2311, 1956, 4726, 4520, 24124, 5709, 1923, 4407, 2094, 1930, 3]}, "items": [{"id": "p_5017", "content": "Capillary Leak Syndrome [SEP] A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hemat", "score": 1, "type": null, "tokenized_content": [2, 9623, 9186, 4741, 3, 43, 2625, 4378, 2007, 30489, 9232, 1927, 5466, 9186, 1941, 2037, 16973, 2460, 8324, 17, 4541, 10436, 7538, 5626, 3]}]}
{"query": {"id": "q_5018", "content": "sirolimus [SEP] veloped a capillary leak syndrome following treatment with oral sirolimus lesional skin cells and activated peripheral blood cells were a", "tokenized_content": [2, 4520, 24124, 3, 6217, 4907, 1007, 43, 9623, 9186, 4741, 2894, 2311, 1956, 4726, 4520, 24124, 5709, 1923, 4407, 2094, 1930, 4128, 5009, 2877, 2094, 1985, 43, 3]}, "items": [{"id": "p_5018", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_5019", "content": "dexamethasone [SEP] atients with psoriasis tended to exhibit greater spontaneous or dexamethasone-induced apoptosis than did normal T cells, particularly in the ", "tokenized_content": [2, 12681, 3, 2019, 6746, 1956, 14109, 10587, 1942, 5987, 3430, 6242, 2014, 12681, 17, 2719, 4091, 2254, 2811, 2791, 62, 2094, 16, 4443, 1922, 1920, 3]}, "items": [{"id": "p_5019", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_5020", "content": "fever [SEP] limus. CONCLUSIONS: Severe adverse effects of sirolimus include fever, anemia, and capillary leak syndrome. These symptoms may be the", "tokenized_content": [2, 9087, 3, 2784, 1957, 18, 4355, 30, 4010, 5246, 2564, 1927, 4520, 24124, 3951, 9087, 16, 10679, 16, 1930, 9623, 9186, 4741, 18, 2144, 3601, 2278, 1998, 1920, 3]}, "items": [{"id": "p_5020", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_5021", "content": "anemia [SEP] CONCLUSIONS: Severe adverse effects of sirolimus include fever, anemia, and capillary leak syndrome. These symptoms may be the result ", "tokenized_content": [2, 10679, 3, 4355, 30, 4010, 5246, 2564, 1927, 4520, 24124, 3951, 9087, 16, 10679, 16, 1930, 9623, 9186, 4741, 18, 2144, 3601, 2278, 1998, 1920, 3211, 3]}, "items": [{"id": "p_5021", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_5022", "content": "capillary leak [SEP] cell activation. After 2 individuals with psoriasis developed a capillary leak syndrome following treatment with oral sirolimus lesional skin ", "tokenized_content": [2, 9623, 9186, 3, 2024, 2936, 18, 2256, 22, 3445, 1956, 14109, 3530, 43, 9623, 9186, 4741, 2894, 2311, 1956, 4726, 4520, 24124, 5709, 1923, 4407, 3]}, "items": [{"id": "p_5022", "content": "Capillary Leak Syndrome [SEP] A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hemat", "score": 1, "type": null, "tokenized_content": [2, 9623, 9186, 4741, 3, 43, 2625, 4378, 2007, 30489, 9232, 1927, 5466, 9186, 1941, 2037, 16973, 2460, 8324, 17, 4541, 10436, 7538, 5626, 3]}]}
{"query": {"id": "q_5023", "content": "inflammatory diseases [SEP] c therapies, clinical monitoring is advisable for patients with inflammatory diseases who are treated with immune modulators.", "tokenized_content": [2, 3769, 3902, 3, 45, 6565, 16, 2535, 5378, 1977, 14683, 2115, 1958, 2132, 1956, 3769, 3902, 2746, 2032, 2868, 1956, 3743, 17455, 18, 3]}, "items": [{"id": "p_5023", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_5024", "content": "glycine [SEP] Contribution of the glycine site of NMDA receptors in rostral and intermediate-caudal parts", "tokenized_content": [2, 10646, 3, 5100, 1927, 1920, 10646, 3200, 1927, 10976, 4086, 1922, 17988, 1930, 6129, 17, 13669, 7516, 3]}, "items": [{"id": "p_5024", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_5025", "content": "NMDA [SEP] Contribution of the glycine site of NMDA receptors in rostral and intermediate-caudal parts of the stria", "tokenized_content": [2, 10976, 3, 5100, 1927, 1920, 10646, 3200, 1927, 10976, 4086, 1922, 17988, 1930, 6129, 17, 13669, 7516, 1927, 1920, 2114, 2126, 3]}, "items": [{"id": "p_5025", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_5026", "content": "glycine [SEP]  aim of the present study was to assess the contribution of the glycine site of NMDA receptors in the striatum to the regulation of mus", "tokenized_content": [2, 10646, 3, 3774, 1927, 1920, 2481, 2161, 1982, 1942, 2634, 1920, 5100, 1927, 1920, 10646, 3200, 1927, 10976, 4086, 1922, 1920, 11259, 1942, 1920, 3640, 1927, 3177, 3]}, "items": [{"id": "p_5026", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_5027", "content": "NMDA [SEP] ent study was to assess the contribution of the glycine site of NMDA receptors in the striatum to the regulation of muscle tone. Mus", "tokenized_content": [2, 10976, 3, 8496, 2161, 1982, 1942, 2634, 1920, 5100, 1927, 1920, 10646, 3200, 1927, 10976, 4086, 1922, 1920, 11259, 1942, 1920, 3640, 1927, 3760, 11020, 18, 3177, 3]}, "items": [{"id": "p_5027", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_5028", "content": "Muscle rigidity [SEP] tic muscles of that joint: gastrocnemius and tibialis anterior. Muscle rigidity was induced by haloperidol (2.5 mg/kg i.p.). 5,7-dichlorokynure", "tokenized_content": [2, 3760, 20471, 3, 18298, 7848, 1927, 1988, 6047, 30, 23700, 1930, 13406, 1937, 5477, 18, 3760, 20471, 1982, 2719, 2007, 25107, 12, 22, 18, 25, 2786, 19, 3621, 51, 18, 3]}, "items": [{"id": "p_5028", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_5029", "content": "haloperidol [SEP] rocnemius and tibialis anterior. Muscle rigidity was induced by haloperidol (2.5 mg/kg i.p.). 5,7-dichlorokynurenic acid (5,7-DCKA), a sele", "tokenized_content": [2, 25107, 3, 10326, 19319, 11519, 1930, 13406, 1937, 5477, 18, 3760, 20471, 1982, 2719, 2007, 25107, 12, 22, 18, 25, 2786, 19, 3621, 51, 18, 58, 18, 13, 18, 25, 3]}, "items": [{"id": "p_5029", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5030", "content": "5,7-dichlorokynurenic acid [SEP] r. Muscle rigidity was induced by haloperidol (2.5 mg/kg i.p.). 5,7-dichlorokynurenic acid (5,7-DCKA), a selective glycine site antagonist, injected in do", "tokenized_content": [2, 25, 16, 27, 17, 29105, 6716, 1022, 24684, 1935, 2687, 3, 60, 18, 3760, 20471, 1982, 2719, 2007, 25107, 12, 22, 18, 25, 2786, 19, 3621, 51, 18, 58, 18, 3]}, "items": [{"id": "p_5030", "content": "5,7-dichlorokynurenic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 27, 17, 29105, 6716, 1022, 24684, 1935, 2687, 3, 3]}]}
{"query": {"id": "q_5031", "content": "5,7-DCKA [SEP] ed by haloperidol (2.5 mg/kg i.p.). 5,7-dichlorokynurenic acid (5,7-DCKA), a selective glycine site antagonist, injected in doses of 2.5", "tokenized_content": [2, 25, 16, 27, 17, 5330, 7640, 3, 3347, 2007, 25107, 12, 22, 18, 25, 2786, 19, 3621, 51, 18, 58, 18, 13, 18, 25, 16, 27, 17, 29105, 6716, 1022, 3]}, "items": [{"id": "p_5031", "content": "5,7-dichlorokynurenic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 27, 17, 29105, 6716, 1022, 24684, 1935, 2687, 3, 3]}]}
{"query": {"id": "q_5032", "content": "muscle rigidity [SEP]  region of the striatum, decreased both the haloperidol-induced muscle rigidity (MMG) and the enhanced electromyographic activity (EMG). 5,7-DC", "tokenized_content": [2, 3760, 20471, 3, 3031, 1927, 1920, 11259, 16, 3261, 2321, 1920, 25107, 17, 2719, 3760, 20471, 12, 2489, 1029, 13, 1930, 1920, 4256, 22755, 4158, 2455, 12, 13952, 13, 18, 3]}, "items": [{"id": "p_5032", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_5033", "content": "lovastatin [SEP] Efficacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia.", "tokenized_content": [2, 18412, 11680, 3, 4348, 1930, 17934, 1927, 18412, 11680, 1922, 24317, 1008, 3089, 1956, 5086, 22862, 18, 3]}, "items": [{"id": "p_5033", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_5034", "content": "hypercholesterolemia [SEP] cacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia.", "tokenized_content": [2, 22862, 3, 9703, 1012, 1930, 17934, 1927, 18412, 11680, 1922, 24317, 1008, 3089, 1956, 5086, 22862, 18, 3]}, "items": [{"id": "p_5034", "content": "Hypercholesterolemia [SEP] A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th per", "score": 1, "type": null, "tokenized_content": [2, 22862, 3, 43, 2625, 1956, 20756, 2149, 2428, 1927, 5463, 1922, 1920, 2877, 18, 2176, 1977, 3608, 1966, 43, 5463, 3113, 15547, 1920, 28463, 2079, 3]}]}
{"query": {"id": "q_5035", "content": "lovastatin [SEP] OBJECTIVE: To evaluate the efficacy and safety of lovastatin in women with moderate hypercholesterolemia. DESIGN: The Expand", "tokenized_content": [2, 18412, 11680, 3, 4470, 30, 1942, 4323, 1920, 4348, 1930, 5407, 1927, 18412, 11680, 1922, 3089, 1956, 5086, 22862, 18, 3036, 30, 1920, 7305, 3]}, "items": [{"id": "p_5035", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_5036", "content": "hypercholesterolemia [SEP] te the efficacy and safety of lovastatin in women with moderate hypercholesterolemia. DESIGN: The Expanded Clinical Evaluation of Lovastatin (EXCEL)", "tokenized_content": [2, 22862, 3, 3602, 1920, 4348, 1930, 5407, 1927, 18412, 11680, 1922, 3089, 1956, 5086, 22862, 18, 3036, 30, 1920, 8899, 2535, 4391, 1927, 18412, 11680, 12, 16784, 13, 3]}, "items": [{"id": "p_5036", "content": "Hypercholesterolemia [SEP] A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th per", "score": 1, "type": null, "tokenized_content": [2, 22862, 3, 43, 2625, 1956, 20756, 2149, 2428, 1927, 5463, 1922, 1920, 2877, 18, 2176, 1977, 3608, 1966, 43, 5463, 3113, 15547, 1920, 28463, 2079, 3]}]}
{"query": {"id": "q_5037", "content": "Lovastatin [SEP] percholesterolemia. DESIGN: The Expanded Clinical Evaluation of Lovastatin (EXCEL) Study, a multicenter, double-blind, diet- and placebo-c", "tokenized_content": [2, 18412, 11680, 3, 7582, 27971, 2156, 6506, 1952, 6026, 18, 3036, 30, 1920, 8899, 2535, 4391, 1927, 18412, 11680, 12, 16784, 13, 2161, 16, 43, 14620, 16, 4825, 17, 7109, 3]}, "items": [{"id": "p_5037", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_5038", "content": "cholesterol [SEP] e efficacy and safety of lovastatin in women with moderate hypercholesterolemia. DESIGN: The Expanded Clinical Evaluation of Lovastatin (EX", "tokenized_content": [2, 5463, 3, 47, 4348, 1930, 5407, 1927, 18412, 11680, 1922, 3089, 1956, 5086, 22862, 18, 3036, 30, 1920, 8899, 2535, 4391, 1927, 18412, 11680, 12, 1975, 3]}, "items": [{"id": "p_5038", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_5039", "content": "triglycerides [SEP] tein (LDL), and high-density lipoprotein (HDL) cholesterol, and triglycerides; and laboratory and clinical evidence of adverse events monitor", "tokenized_content": [2, 13631, 3, 3602, 1921, 12, 8017, 13, 16, 1930, 2149, 17, 3824, 9694, 12, 8210, 13, 5463, 16, 1930, 13631, 31, 1930, 4542, 1930, 2535, 3095, 1927, 5246, 3916, 8434, 3]}, "items": [{"id": "p_5039", "content": "Triglycerides [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13631, 3, 3]}]}
{"query": {"id": "q_5040", "content": "Cholesterol [SEP] om 82% to 95% of lovastatin-treated women achieved the National Cholesterol Education Program goal of LDL cholesterol levels less than 4.14", "tokenized_content": [2, 5463, 3, 7254, 6175, 9, 1942, 3002, 9, 1927, 18412, 11680, 17, 2868, 3089, 5032, 1920, 3852, 5463, 4767, 3688, 6640, 1927, 8017, 5463, 2428, 2941, 2254, 24, 18, 2607, 3]}, "items": [{"id": "p_5040", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_5041", "content": "Myopathy [SEP]  in 0.1% of women and were dose dependent above the 20-mg dose. Myopathy, defined as muscle symptoms with creatine kinase elevations gre", "tokenized_content": [2, 25017, 3, 1922, 20, 18, 21, 9, 1927, 3089, 1930, 1985, 3253, 3100, 3538, 1920, 2036, 17, 2786, 3253, 18, 25017, 16, 3608, 1966, 3760, 3601, 1956, 17784, 4016, 17554, 3]}, "items": [{"id": "p_5041", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_5042", "content": "creatine [SEP] above the 20-mg dose. Myopathy, defined as muscle symptoms with creatine kinase elevations greater than 10 times the upper limit of norm", "tokenized_content": [2, 17784, 3, 3538, 1920, 2036, 17, 2786, 3253, 18, 25017, 16, 3608, 1966, 3760, 3601, 1956, 17784, 4016, 17554, 3430, 2254, 2119, 3586, 1920, 5199, 4411, 1927, 5308, 3]}, "items": [{"id": "p_5042", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_5043", "content": "REM sleep deprivation [SEP] REM sleep deprivation changes behavioral response to catecholaminergic and serotonerg", "tokenized_content": [2, 2500, 5006, 10837, 3, 2500, 5006, 10837, 2840, 5343, 2644, 1942, 23483, 1005, 11545, 1930, 9752, 2290, 1005, 1029, 3]}, "items": [{"id": "p_5043", "content": "Sleep Deprivation [SEP] The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiolog", "score": 1, "type": null, "tokenized_content": [2, 5006, 10837, 3, 1920, 3360, 1927, 3301, 17080, 1927, 5006, 2441, 3599, 2961, 16, 2810, 1942, 3308, 3916, 16, 2014, 2037, 43, 4743, 5386, 1927, 9211, 11149, 2021, 3]}]}
{"query": {"id": "q_5044", "content": "REM sleep deprivation [SEP] The effects of REM sleep deprivation (REMD) on apomorphine-induced aggressiveness and quipazine-indu", "tokenized_content": [2, 2500, 5006, 10837, 3, 1920, 2564, 1927, 2500, 5006, 10837, 12, 2500, 1007, 13, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 23161, 1930, 2571, 19514, 22030, 2912, 17, 2063, 3]}, "items": [{"id": "p_5044", "content": "Sleep Deprivation [SEP] The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiolog", "score": 1, "type": null, "tokenized_content": [2, 5006, 10837, 3, 1920, 3360, 1927, 3301, 17080, 1927, 5006, 2441, 3599, 2961, 16, 2810, 1942, 3308, 3916, 16, 2014, 2037, 43, 4743, 5386, 1927, 9211, 11149, 2021, 3]}]}
{"query": {"id": "q_5045", "content": "REMD [SEP] The effects of REM sleep deprivation (REMD) on apomorphine-induced aggressiveness and quipazine-induced he", "tokenized_content": [2, 2500, 1007, 3, 1920, 2564, 1927, 2500, 5006, 10837, 12, 2500, 1007, 13, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 23161, 1930, 2571, 19514, 22030, 2912, 17, 2719, 2234, 3]}, "items": [{"id": "p_5045", "content": "Sleep Deprivation [SEP] The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiolog", "score": 1, "type": null, "tokenized_content": [2, 5006, 10837, 3, 1920, 3360, 1927, 3301, 17080, 1927, 5006, 2441, 3599, 2961, 16, 2810, 1942, 3308, 3916, 16, 2014, 2037, 43, 4743, 5386, 1927, 9211, 11149, 2021, 3]}]}
{"query": {"id": "q_5046", "content": "apomorphine [SEP] The effects of REM sleep deprivation (REMD) on apomorphine-induced aggressiveness and quipazine-induced head twitches in r", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 1920, 2564, 1927, 2500, 5006, 10837, 12, 2500, 1007, 13, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 23161, 1930, 2571, 19514, 22030, 2912, 3]}, "items": [{"id": "p_5046", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_5047", "content": "aggressiveness [SEP]  effects of REM sleep deprivation (REMD) on apomorphine-induced aggressiveness and quipazine-induced head twitches in rats were determined. Fo", "tokenized_content": [2, 23161, 3, 2564, 1927, 2500, 5006, 10837, 12, 2500, 1007, 13, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 23161, 1930, 2571, 19514, 22030, 2912, 17, 2719, 4469, 21596, 1918, 3]}, "items": [{"id": "p_5047", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_5048", "content": "quipazine [SEP] ep deprivation (REMD) on apomorphine-induced aggressiveness and quipazine-induced head twitches in rats were determined. Forty-eight hr o", "tokenized_content": [2, 2571, 19514, 22030, 2912, 3, 2630, 10837, 12, 2500, 1007, 13, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 23161, 1930, 2571, 19514, 22030, 2912, 17, 2719, 4469, 21596, 1918, 3]}, "items": [{"id": "p_5048", "content": "Quipazine [SEP] A pharmacologic congener of serotonin that contracts smooth muscle and has actions similar to those of tricyclic antidepressants", "score": 1, "type": null, "tokenized_content": [2, 2571, 19514, 22030, 2912, 3, 43, 17225, 8680, 1915, 1927, 11153, 1988, 14456, 1036, 6689, 3760, 1930, 2258, 7728, 2551, 1942, 2690, 1927, 12258, 13153, 17722, 3]}]}
{"query": {"id": "q_5049", "content": "head twitches [SEP] MD) on apomorphine-induced aggressiveness and quipazine-induced head twitches in rats were determined. Forty-eight hr of REMD increased apomo", "tokenized_content": [2, 4469, 21596, 1918, 3, 4445, 13, 1990, 11466, 12492, 11119, 7969, 2912, 17, 2719, 23161, 1930, 2571, 19514, 22030, 2912, 17, 2719, 4469, 21596, 1918, 1922, 3615, 1985, 3180, 18, 3]}, "items": [{"id": "p_5049", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_5050", "content": "haloperidol [SEP] Extrapyramidal side effects and oral haloperidol: an analysis of explanatory patient and treatment characteristi", "tokenized_content": [2, 25107, 3, 21346, 3553, 25238, 1923, 4159, 2564, 1930, 4726, 25107, 30, 1925, 2333, 1927, 17644, 2774, 1930, 2311, 3327, 1914, 3]}, "items": [{"id": "p_5050", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5051", "content": "haloperidol [SEP] al side effects (EPS) was evaluated in 98 patients treated with haloperidol. The incidence of parkinsonism was higher at higher doses of ha", "tokenized_content": [2, 25107, 3, 1969, 4159, 2564, 12, 9178, 13, 1982, 3747, 1922, 5613, 2132, 2868, 1956, 25107, 18, 1920, 4332, 1927, 26214, 1982, 2580, 2019, 2580, 5312, 1927, 2118, 3]}, "items": [{"id": "p_5051", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5052", "content": "parkinsonism [SEP] uated in 98 patients treated with haloperidol. The incidence of parkinsonism was higher at higher doses of haloperidol and in younger patien", "tokenized_content": [2, 26214, 3, 17942, 2013, 1922, 5613, 2132, 2868, 1956, 25107, 18, 1920, 4332, 1927, 26214, 1982, 2580, 2019, 2580, 5312, 1927, 25107, 1930, 1922, 7237, 2091, 1917, 3]}, "items": [{"id": "p_5052", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_5053", "content": "Akathisia [SEP] young and old patients when given after parkinsonism developed. Akathisia was controlled by the benzodiazepine lorazepam in 14 out of 16 ", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 4201, 1930, 4156, 2132, 2469, 3258, 2256, 26214, 3530, 18, 4464, 2183, 1937, 2126, 1982, 4642, 2007, 1920, 27266, 16394, 28231, 1922, 2607, 2397, 1927, 3]}, "items": [{"id": "p_5053", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_5054", "content": "benzodiazepine [SEP] n after parkinsonism developed. Akathisia was controlled by the benzodiazepine lorazepam in 14 out of 16 patients, while prophylactic antipark", "tokenized_content": [2, 27266, 3, 56, 2256, 26214, 3530, 18, 4464, 2183, 1937, 2126, 1982, 4642, 2007, 1920, 27266, 16394, 28231, 1922, 2607, 2397, 1927, 2641, 2132, 16, 2679, 14847, 24290, 1040, 3]}, "items": [{"id": "p_5054", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_5055", "content": "lorazepam [SEP] onism developed. Akathisia was controlled by the benzodiazepine lorazepam in 14 out of 16 patients, while prophylactic antiparkinsonians ", "tokenized_content": [2, 16394, 28231, 3, 1990, 2421, 3530, 18, 4464, 2183, 1937, 2126, 1982, 4642, 2007, 1920, 27266, 16394, 28231, 1922, 2607, 2397, 1927, 2641, 2132, 16, 2679, 14847, 24290, 14488, 6114, 3]}, "items": [{"id": "p_5055", "content": "Lorazepam [SEP] A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sed", "score": 1, "type": null, "tokenized_content": [2, 16394, 28231, 3, 43, 27266, 2251, 1966, 1925, 2246, 17, 5592, 5899, 1956, 3855, 4159, 2564, 18, 2176, 2222, 2258, 25810, 3153, 16, 26572, 2031, 16, 1930, 7743, 6276, 3]}]}
{"query": {"id": "q_5056", "content": "Hepatic veno-occlusive disease [SEP] Hepatic veno-occlusive disease caused by 6-thioguanine.", "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 6095, 8102, 1037, 17, 28715, 2573, 4189, 2007, 26, 17, 15331, 11056, 7290, 18, 3]}, "items": [{"id": "p_5056", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_5057", "content": "6-thioguanine [SEP] Hepatic veno-occlusive disease caused by 6-thioguanine.", "tokenized_content": [2, 26, 17, 15331, 11056, 7290, 3, 6095, 8102, 1037, 17, 28715, 2573, 4189, 2007, 26, 17, 15331, 11056, 7290, 18, 3]}, "items": [{"id": "p_5057", "content": "Thioguanine [SEP] An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15331, 11056, 7290, 3, 1925, 29128, 9969, 3547, 2154, 2222, 2258, 20330, 9215, 4627, 12191, 2057, 4615, 18, 1920, 2838, 1977, 2251, 1922, 1920, 3181, 1927, 3939, 8111, 18, 3]}]}
{"query": {"id": "q_5058", "content": "veno-occlusive disease of the liver [SEP] Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia ", "tokenized_content": [2, 8102, 1037, 17, 28715, 2573, 1927, 1920, 3568, 3, 5908, 10743, 8102, 1037, 17, 28715, 2573, 1927, 1920, 3568, 3530, 1922, 43, 3020, 17, 2476, 17, 4156, 2323, 1956, 3939, 3]}, "items": [{"id": "p_5058", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_5059", "content": "acute lymphocytic leukemia [SEP] lusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Seri", "tokenized_content": [2, 3939, 18921, 8111, 3, 10908, 12924, 1961, 2573, 1927, 1920, 3568, 3530, 1922, 43, 3020, 17, 2476, 17, 4156, 2323, 1956, 3939, 18921, 8111, 2256, 2119, 3221, 1927, 6291, 3181, 3]}, "items": [{"id": "p_5059", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_5060", "content": "6-thioguanine [SEP] ymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of", "tokenized_content": [2, 26, 17, 15331, 11056, 7290, 3, 23143, 2102, 8316, 8111, 2256, 2119, 3221, 1927, 6291, 3181, 1956, 26, 17, 15331, 11056, 7290, 18, 9285, 3568, 9782, 2594, 1920, 2740, 1930, 3]}, "items": [{"id": "p_5060", "content": "Thioguanine [SEP] An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15331, 11056, 7290, 3, 1925, 29128, 9969, 3547, 2154, 2222, 2258, 20330, 9215, 4627, 12191, 2057, 4615, 18, 1920, 2838, 1977, 2251, 1922, 1920, 3181, 1927, 3939, 8111, 18, 3]}]}
{"query": {"id": "q_5061", "content": "fibrosis [SEP] lthough this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented", "tokenized_content": [2, 6769, 3, 3457, 15492, 2509, 2052, 2573, 1982, 5908, 10743, 16, 2673, 2316, 2879, 21148, 6769, 3001, 1920, 4262, 6095, 14785, 14583, 18, 2052, 3087, 3549, 3]}, "items": [{"id": "p_5061", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_5062", "content": "hepatic veno-occlusive disease [SEP] ity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related ", "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 2176, 1012, 1942, 7974, 1920, 12434, 4075, 1927, 5908, 10743, 6095, 8102, 1037, 17, 28715, 2573, 2338, 2367, 16, 1930, 2278, 1998, 1920, 3]}, "items": [{"id": "p_5062", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_5063", "content": "ifosfamide [SEP] Treatment of ifosfamide-induced urothelial toxicity by oral administration of sodium 2-", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2311, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 23182, 5532, 2007, 4726, 4183, 1927, 5227, 22, 17, 3]}, "items": [{"id": "p_5063", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_5064", "content": "urothelial toxicity [SEP] Treatment of ifosfamide-induced urothelial toxicity by oral administration of sodium 2-mercaptoethane sulphonate (M", "tokenized_content": [2, 23182, 5532, 3, 2311, 1927, 2647, 1951, 6016, 16408, 1021, 17, 2719, 23182, 5532, 2007, 4726, 4183, 1927, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 55, 3]}, "items": [{"id": "p_5064", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_5065", "content": "sodium 2-mercaptoethane sulphonate [SEP] fosfamide-induced urothelial toxicity by oral administration of sodium 2-mercaptoethane sulphonate (MESNA) to patients with inoperable lung cancer.", "tokenized_content": [2, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 3, 10395, 6016, 16408, 1021, 17, 2719, 23182, 5532, 2007, 4726, 4183, 1927, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 3]}, "items": [{"id": "p_5065", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_5066", "content": "MESNA [SEP] y by oral administration of sodium 2-mercaptoethane sulphonate (MESNA) to patients with inoperable lung cancer.", "tokenized_content": [2, 4438, 2175, 3, 67, 2007, 4726, 4183, 1927, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 1942, 2132, 1956, 26848, 2116, 2115, 3614, 2539, 18, 3]}, "items": [{"id": "p_5066", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_5067", "content": "lung cancer [SEP] 2-mercaptoethane sulphonate (MESNA) to patients with inoperable lung cancer.", "tokenized_content": [2, 3614, 2539, 3, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 1942, 2132, 1956, 26848, 2116, 2115, 3614, 2539, 18, 3]}, "items": [{"id": "p_5067", "content": "Lung Neoplasms [SEP] Tumors or cancer of the LUNG.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3614, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_5068", "content": "thiol [SEP] The protective effect of oral administration of the thiol compound sodium 2-mercaptoethane sulphonate (MESNA) against uro", "tokenized_content": [2, 13914, 3, 1920, 6337, 2495, 1927, 4726, 4183, 1927, 1920, 13914, 3547, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 3316, 14984, 3]}, "items": [{"id": "p_5068", "content": "Sulfhydryl Compounds [SEP] Compounds containing the -SH radical.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30011, 2199, 4300, 3, 4300, 3165, 1920, 17, 2044, 6917, 18, 3]}]}
{"query": {"id": "q_5069", "content": "sodium 2-mercaptoethane sulphonate [SEP]  protective effect of oral administration of the thiol compound sodium 2-mercaptoethane sulphonate (MESNA) against urothelial toxicity induced by ifosfamide (IF) ", "tokenized_content": [2, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 3, 6337, 2495, 1927, 4726, 4183, 1927, 1920, 13914, 3547, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 3]}, "items": [{"id": "p_5069", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_5070", "content": "MESNA [SEP] ation of the thiol compound sodium 2-mercaptoethane sulphonate (MESNA) against urothelial toxicity induced by ifosfamide (IF) was tes", "tokenized_content": [2, 4438, 2175, 3, 2019, 2001, 1927, 1920, 13914, 3547, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 3316, 23182, 5532, 2719, 2007, 2647, 1951, 6016, 16408, 3]}, "items": [{"id": "p_5070", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_5071", "content": "urothelial toxicity [SEP] iol compound sodium 2-mercaptoethane sulphonate (MESNA) against urothelial toxicity induced by ifosfamide (IF) was tested in a group of 45 patients", "tokenized_content": [2, 23182, 5532, 3, 23041, 3547, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 3316, 23182, 5532, 2719, 2007, 2647, 1951, 6016, 16408, 1021, 12, 2647, 13, 3]}, "items": [{"id": "p_5071", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_5072", "content": "ifosfamide [SEP] thane sulphonate (MESNA) against urothelial toxicity induced by ifosfamide (IF) was tested in a group of 45 patients with inoperable lung ", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2254, 1021, 13528, 8870, 12, 4438, 2175, 13, 3316, 23182, 5532, 2719, 2007, 2647, 1951, 6016, 16408, 1021, 12, 2647, 13, 1982, 3620, 1922, 3]}, "items": [{"id": "p_5072", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_5073", "content": "IF [SEP] nate (MESNA) against urothelial toxicity induced by ifosfamide (IF) was tested in a group of 45 patients with inoperable lung canc", "tokenized_content": [2, 2647, 3, 3898, 1021, 12, 4438, 2175, 13, 3316, 23182, 5532, 2719, 2007, 2647, 1951, 6016, 16408, 1021, 12, 2647, 13, 1982, 3620, 1922, 43, 2210, 1927, 3607, 2132, 1956, 3]}, "items": [{"id": "p_5073", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_5074", "content": "lung cancer [SEP] amide (IF) was tested in a group of 45 patients with inoperable lung cancer under treatment with IF (2250 mg/m2 on days 2-5) as part of a p", "tokenized_content": [2, 3614, 2539, 3, 13601, 12, 2647, 13, 1982, 3620, 1922, 43, 2210, 1927, 3607, 2132, 1956, 26848, 2116, 2115, 3614, 2539, 2441, 2311, 1956, 2647, 12, 16056, 1008, 2786, 19, 3]}, "items": [{"id": "p_5074", "content": "Lung Neoplasms [SEP] Tumors or cancer of the LUNG.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3614, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_5075", "content": "haematuria [SEP] s treatment we observed 10 episodes of asymptomatic microscopic haematuria and no episodes of gross haematuria. In this group of 45 patien", "tokenized_content": [2, 13080, 8754, 3, 61, 2311, 2038, 2528, 2119, 9232, 1927, 9978, 10372, 13080, 8754, 1930, 2239, 9232, 1927, 10461, 13080, 8754, 18, 1922, 2052, 2210, 1927, 3607, 2091, 1917, 3]}, "items": [{"id": "p_5075", "content": "Hematuria [SEP] Presence of blood in the urine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30267, 3, 2990, 1927, 2877, 1922, 1920, 6960, 18, 3]}]}
{"query": {"id": "q_5076", "content": "bladder irritation [SEP] l patients developed either gross haematuria and/or symptoms of bladder irritation (cystitis and pollakisuria). There were no appreciable differen", "tokenized_content": [2, 7821, 24130, 3, 54, 2132, 3530, 3108, 10461, 13080, 8754, 1930, 19, 2014, 3601, 1927, 7821, 24130, 12, 9446, 3678, 1930, 6572, 23298, 8754, 13, 18, 2276, 1985, 2239, 21800, 3]}, "items": [{"id": "p_5076", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_5077", "content": "cystitis [SEP]  either gross haematuria and/or symptoms of bladder irritation (cystitis and pollakisuria). There were no appreciable differences betwee", "tokenized_content": [2, 9446, 3678, 3, 3108, 10461, 13080, 8754, 1930, 19, 2014, 3601, 1927, 7821, 24130, 12, 9446, 3678, 1930, 6572, 23298, 8754, 13, 18, 2276, 1985, 2239, 21800, 2886, 2143, 2172, 3]}, "items": [{"id": "p_5077", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_5078", "content": "pollakisuria [SEP]  haematuria and/or symptoms of bladder irritation (cystitis and pollakisuria). There were no appreciable differences between the MESNA serie", "tokenized_content": [2, 6572, 23298, 8754, 3, 13080, 8754, 1930, 19, 2014, 3601, 1927, 7821, 24130, 12, 9446, 3678, 1930, 6572, 23298, 8754, 13, 18, 2276, 1985, 2239, 21800, 2886, 2192, 1920, 4438, 3]}, "items": [{"id": "p_5078", "content": "Urination Disorders [SEP] Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and comp", "score": 1, "type": null, "tokenized_content": [2, 3674, 2636, 4414, 3, 6754, 1922, 1920, 2585, 1927, 6960, 27682, 16, 2710, 7821, 2285, 16, 3528, 1927, 3674, 2636, 16, 1966, 2486, 1966, 1920, 3776, 1930, 2059, 3]}]}
{"query": {"id": "q_5079", "content": "toxicity [SEP] d sodium 2-mercaptoethane sulphonate (MESNA) against urothelial toxicity induced by ifosfamide (IF) was tested in a group of 45 patients", "tokenized_content": [2, 5532, 3, 46, 5227, 22, 17, 17275, 3184, 2516, 13528, 8870, 12, 4438, 2175, 13, 3316, 23182, 5532, 2719, 2007, 2647, 1951, 6016, 16408, 1021, 12, 2647, 13, 1982, 3620, 3]}, "items": [{"id": "p_5079", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5080", "content": "hypaque 76 [SEP] Time course alterations of QTC interval due to hypaque 76.", "tokenized_content": [2, 2483, 15287, 2182, 5439, 3, 2367, 4914, 5996, 1927, 23946, 4979, 2810, 1942, 2483, 15287, 2182, 5439, 18, 3]}, "items": [{"id": "p_5080", "content": "urovision [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14984, 7400, 2001, 3, 3]}]}
{"query": {"id": "q_5081", "content": "hypaque 76 [SEP] seconds and one, three, five and ten minutes after injection of hypaque 76. The subjects were ten patients found to have normal left ventr", "tokenized_content": [2, 2483, 15287, 2182, 5439, 3, 9362, 1930, 2340, 16, 2559, 16, 3628, 1930, 5656, 4814, 2256, 4107, 1927, 2483, 15287, 2182, 5439, 18, 1920, 3297, 1985, 5656, 2132, 2435, 1942, 3]}, "items": [{"id": "p_5081", "content": "urovision [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14984, 7400, 2001, 3, 3]}]}
{"query": {"id": "q_5082", "content": "QTC prolongation [SEP]  have normal left ventricles and coronary arteries. Significant QTC prolongation occurred in 30 seconds to one minute in association with marked", "tokenized_content": [2, 23946, 20334, 3, 2162, 2791, 3506, 21008, 1930, 5846, 9345, 18, 2228, 23946, 20334, 4807, 1922, 2627, 9362, 1942, 2340, 8623, 1922, 3279, 1956, 4961, 3]}, "items": [{"id": "p_5082", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_5083", "content": "hypotension [SEP] occurred in 30 seconds to one minute in association with marked hypotension and elevation of cardiac output.", "tokenized_content": [2, 16453, 3, 4807, 1922, 2627, 9362, 1942, 2340, 8623, 1922, 3279, 1956, 4961, 16453, 1930, 8644, 1927, 4435, 6647, 18, 3]}, "items": [{"id": "p_5083", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_5084", "content": "prostate cancer [SEP] Production of autochthonous prostate cancer in Lobund-Wistar rats by treatments with N-nitroso-N-methylurea", "tokenized_content": [2, 5683, 2539, 3, 3372, 1927, 22658, 19253, 10647, 11873, 1957, 5683, 2539, 1922, 6948, 2652, 17, 15668, 3615, 2007, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 3]}, "items": [{"id": "p_5084", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_5085", "content": "N-nitroso-N-methylurea [SEP] honous prostate cancer in Lobund-Wistar rats by treatments with N-nitroso-N-methylurea and testosterone.", "tokenized_content": [2, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 3, 15372, 2080, 5683, 2539, 1922, 6948, 2652, 17, 15668, 3615, 2007, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 3]}, "items": [{"id": "p_5085", "content": "Methylnitrosourea [SEP] A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 8635, 1997, 1951, 2257, 5376, 3, 43, 16665, 2257, 5376, 3547, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 3]}]}
{"query": {"id": "q_5086", "content": "testosterone [SEP] obund-Wistar rats by treatments with N-nitroso-N-methylurea and testosterone.", "tokenized_content": [2, 10592, 3, 2384, 2652, 17, 15668, 3615, 2007, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 1930, 10592, 18, 3]}, "items": [{"id": "p_5086", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_5087", "content": "prostate adenocarcinomas [SEP] 0% of Lobund-Wistar (L-W) strain rats developed large, palpable prostate adenocarcinomas (PAs) following treatments with N-nitroso-N-methylurea (CAS: 68", "tokenized_content": [2, 5683, 19960, 3, 20, 9, 1927, 6948, 2652, 17, 15668, 12, 54, 17, 65, 13, 3943, 3615, 3530, 3103, 16, 24845, 5683, 19960, 12, 9233, 13, 2894, 4930, 1956, 56, 3]}, "items": [{"id": "p_5087", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_5088", "content": "PAs [SEP] strain rats developed large, palpable prostate adenocarcinomas (PAs) following treatments with N-nitroso-N-methylurea (CAS: 684-93-", "tokenized_content": [2, 9233, 3, 3943, 3615, 3530, 3103, 16, 24845, 5683, 19960, 12, 9233, 13, 2894, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 12, 4373, 30, 5117, 1006, 3]}, "items": [{"id": "p_5088", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_5089", "content": "N-nitroso-N-methylurea [SEP] lpable prostate adenocarcinomas (PAs) following treatments with N-nitroso-N-methylurea (CAS: 684-93-5) and testosterone propionate [(TP) CAS: 57-85-2]", "tokenized_content": [2, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 3, 16316, 7272, 5683, 19960, 12, 9233, 13, 2894, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 12, 3]}, "items": [{"id": "p_5089", "content": "Methylnitrosourea [SEP] A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 8635, 1997, 1951, 2257, 5376, 3, 43, 16665, 2257, 5376, 3547, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 3]}]}
{"query": {"id": "q_5090", "content": "testosterone propionate [SEP] wing treatments with N-nitroso-N-methylurea (CAS: 684-93-5) and testosterone propionate [(TP) CAS: 57-85-2], and most of the tumor-bearing rats manifes", "tokenized_content": [2, 10592, 24682, 3, 12920, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 12, 4373, 30, 5117, 1006, 17, 6156, 17, 25, 13, 1930, 10592, 24682, 37, 12, 3]}, "items": [{"id": "p_5090", "content": "Testosterone Propionate [SEP] An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10592, 24682, 3, 1925, 9603, 1927, 10592, 1956, 43, 24682, 6636, 2019, 1920, 2752, 17, 4666, 3507, 18, 3]}]}
{"query": {"id": "q_5091", "content": "TP [SEP] roso-N-methylurea (CAS: 684-93-5) and testosterone propionate [(TP) CAS: 57-85-2], and most of the tumor-bearing rats manifested m", "tokenized_content": [2, 6213, 3, 4742, 1037, 17, 56, 17, 4963, 16648, 12, 4373, 30, 5117, 1006, 17, 6156, 17, 25, 13, 1930, 10592, 24682, 37, 12, 6213, 13, 4373, 30, 4786, 17, 3]}, "items": [{"id": "p_5091", "content": "Testosterone Propionate [SEP] An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10592, 24682, 3, 1925, 9603, 1927, 10592, 1956, 43, 24682, 6636, 2019, 1920, 2752, 17, 4666, 3507, 18, 3]}]}
{"query": {"id": "q_5092", "content": "tumor [SEP] nd testosterone propionate [(TP) CAS: 57-85-2], and most of the tumor-bearing rats manifested metastatic lesions. The incubation peri", "tokenized_content": [2, 2798, 3, 8026, 10592, 24682, 37, 12, 6213, 13, 4373, 30, 4786, 17, 5140, 17, 22, 39, 16, 1930, 2501, 1927, 1920, 2798, 17, 8188, 3615, 16687, 6476, 4518, 18, 3]}, "items": [{"id": "p_5092", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5093", "content": "PA [SEP] strain rats developed large, palpable prostate adenocarcinomas (PAs) following treatments with N-nitroso-N-methylurea (CAS: 684-93", "tokenized_content": [2, 3838, 3, 3943, 3615, 3530, 3103, 16, 24845, 5683, 19960, 12, 9233, 13, 2894, 4930, 1956, 56, 17, 16665, 1037, 17, 56, 17, 4963, 16648, 12, 4373, 30, 5117, 1006, 3]}, "items": [{"id": "p_5093", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_5094", "content": "prostate cancer [SEP]  enhancement agent, with primary emphasis on the development of prostate cancer.", "tokenized_content": [2, 5683, 2539, 3, 7489, 5899, 16, 1956, 3065, 12286, 1990, 1920, 2740, 1927, 5683, 2539, 18, 3]}, "items": [{"id": "p_5094", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_5095", "content": "dystonia [SEP] A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the ", "tokenized_content": [2, 23357, 3, 43, 23357, 17, 3189, 4741, 2256, 21908, 12, 19864, 19, 16287, 13, 4177, 1927, 1920, 3]}, "items": [{"id": "p_5095", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_5096", "content": "MSH [SEP] A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.", "tokenized_content": [2, 19864, 3, 43, 23357, 17, 3189, 4741, 2256, 21908, 12, 19864, 19, 16287, 13, 4177, 1927, 1920, 3067, 6730, 6580, 3466, 1957, 18, 3]}, "items": [{"id": "p_5096", "content": "Melanocyte-Stimulating Hormones [SEP] Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulat", "score": 1, "type": null, "tokenized_content": [2, 5313, 4463, 17, 9868, 10224, 3, 5320, 1956, 1920, 3682, 1942, 9084, 22852, 2094, 21408, 1922, 9902, 1930, 5313, 14820, 1922, 2826, 14976, 18, 2007, 3473, 1926, 3]}]}
{"query": {"id": "q_5097", "content": "ACTH [SEP] A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.", "tokenized_content": [2, 16287, 3, 43, 23357, 17, 3189, 4741, 2256, 21908, 12, 19864, 19, 16287, 13, 4177, 1927, 1920, 3067, 6730, 6580, 3466, 1957, 18, 3]}, "items": [{"id": "p_5097", "content": "Adrenocorticotropic Hormone [SEP] An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid ", "score": 1, "type": null, "tokenized_content": [2, 7206, 10323, 8405, 6365, 3, 1925, 5477, 10621, 6365, 1988, 11803, 1920, 10651, 4997, 1930, 2496, 3372, 1927, 14610, 18, 16287, 1977, 43, 3886, 17, 3835, 2687, 3]}]}
{"query": {"id": "q_5098", "content": "movement disorder [SEP] The movement disorder investigated in these studies has some features in common with ", "tokenized_content": [2, 5829, 4770, 3, 1920, 5829, 4770, 3845, 1922, 2144, 2351, 2258, 2673, 4075, 1922, 3059, 1956, 3]}, "items": [{"id": "p_5098", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_5099", "content": "dystonia [SEP] these studies has some features in common with human idiopathic dystonia, and information obtained in these studies may be of potential ", "tokenized_content": [2, 23357, 3, 2144, 2351, 2258, 2673, 4075, 1922, 3059, 1956, 2616, 13513, 23357, 16, 1930, 2988, 2926, 1922, 2144, 2351, 2278, 1998, 1927, 2889, 3]}, "items": [{"id": "p_5099", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_5100", "content": "ACTH [SEP]  as to the following: (a) what receptors were stimulated by the ACTH N-terminal fragments at the LC that resulted in this disorder; ", "tokenized_content": [2, 16287, 3, 1966, 1942, 1920, 2894, 30, 12, 43, 13, 4663, 4086, 1985, 5449, 2007, 1920, 16287, 56, 17, 4262, 6535, 2019, 1920, 5236, 1988, 4306, 1922, 2052, 4770, 31, 3]}, "items": [{"id": "p_5100", "content": "Adrenocorticotropic Hormone [SEP] An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid ", "score": 1, "type": null, "tokenized_content": [2, 7206, 10323, 8405, 6365, 3, 1925, 5477, 10621, 6365, 1988, 11803, 1920, 10651, 4997, 1930, 2496, 3372, 1927, 14610, 18, 16287, 1977, 43, 3886, 17, 3835, 2687, 3]}]}
{"query": {"id": "q_5101", "content": "depression [SEP]  the ceruleo-cerebellar pathway, did indeed cause the long-term depression at Purkinje cell synapses (previously described by others) that", "tokenized_content": [2, 4621, 3, 1920, 6580, 3466, 1037, 17, 11459, 3374, 16, 2811, 5087, 3936, 1920, 2815, 17, 2576, 4621, 2019, 18296, 2024, 10373, 12, 3024, 2910, 2007, 4991, 13, 1988, 3]}, "items": [{"id": "p_5101", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_5102", "content": "Dexmedetomidine [SEP] Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-", "tokenized_content": [2, 26854, 3, 26854, 16, 8290, 2596, 4101, 4595, 17, 22, 25090, 1036, 16, 10299, 27059, 17, 3]}, "items": [{"id": "p_5102", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_5103", "content": "muscle rigidity [SEP]  through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat.", "tokenized_content": [2, 3760, 20471, 3, 2596, 4101, 4595, 17, 22, 25090, 1036, 16, 10299, 27059, 17, 2719, 3760, 20471, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_5103", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_5104", "content": "dexmedetomidine [SEP] The highly-selective alpha-2 adrenergic agonist dexmedetomidine (D-MED) is capable of inducing muscle flaccidity and anesthesia", "tokenized_content": [2, 26854, 3, 1920, 3626, 17, 5328, 4595, 17, 22, 13672, 7829, 26854, 12, 46, 17, 2242, 13, 1977, 7131, 1927, 7834, 3760, 2300, 3339, 5212, 1930, 8871, 3]}, "items": [{"id": "p_5104", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_5105", "content": "D-MED [SEP] he highly-selective alpha-2 adrenergic agonist dexmedetomidine (D-MED) is capable of inducing muscle flaccidity and anesthesia in rat", "tokenized_content": [2, 46, 17, 2242, 3, 2234, 3626, 17, 5328, 4595, 17, 22, 13672, 7829, 26854, 12, 46, 17, 2242, 13, 1977, 7131, 1927, 7834, 3760, 2300, 3339, 5212, 1930, 8871, 1922, 3]}, "items": [{"id": "p_5105", "content": "Dexmedetomidine [SEP] A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the r", "score": 1, "type": null, "tokenized_content": [2, 26854, 3, 43, 16045, 10533, 1988, 1977, 1925, 7829, 1927, 13672, 4595, 17, 22, 4086, 18, 2176, 1977, 6538, 17, 2712, 1942, 2242, 24840, 16, 2154, 1977, 1920, 60, 3]}]}
{"query": {"id": "q_5106", "content": "muscle flaccidity [SEP] renergic agonist dexmedetomidine (D-MED) is capable of inducing muscle flaccidity and anesthesia in rats and dogs. Intense generalized muscle rig", "tokenized_content": [2, 3760, 2300, 3339, 5212, 3, 3866, 5237, 7829, 26854, 12, 46, 17, 2242, 13, 1977, 7131, 1927, 7834, 3760, 2300, 3339, 5212, 1930, 8871, 1922, 3615, 1930, 7894, 18, 10702, 3]}, "items": [{"id": "p_5106", "content": "Muscle Hypotonia [SEP] A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3760, 12201, 6114, 3, 43, 7798, 2306, 1927, 1920, 7345, 3760, 11020, 4961, 2007, 43, 9597, 3554, 1942, 9832, 15192, 18, 3]}]}
{"query": {"id": "q_5107", "content": "muscle rigidity [SEP] flaccidity and anesthesia in rats and dogs. Intense generalized muscle rigidity is an undesirable side effect of potent opiate agonists. Althou", "tokenized_content": [2, 3760, 20471, 3, 2300, 3339, 5212, 1930, 8871, 1922, 3615, 1930, 7894, 18, 10702, 9612, 3760, 20471, 1977, 1925, 21837, 4159, 2495, 1927, 6828, 27059, 9849, 18, 2874, 4468, 3]}, "items": [{"id": "p_5107", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_5108", "content": "rigidity [SEP] ity and anesthesia in rats and dogs. Intense generalized muscle rigidity is an undesirable side effect of potent opiate agonists. Althou", "tokenized_content": [2, 20471, 3, 2176, 1012, 1930, 8871, 1922, 3615, 1930, 7894, 18, 10702, 9612, 3760, 20471, 1977, 1925, 21837, 4159, 2495, 1927, 6828, 27059, 9849, 18, 2874, 4468, 3]}, "items": [{"id": "p_5108", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_5109", "content": "alfentanil [SEP] ent with D-MED prevents the muscle rigidity caused by high-dose alfentanil anesthesia in the rat. Animals (n = 42) were treated intraperit", "tokenized_content": [2, 17913, 25722, 3, 8496, 1956, 46, 17, 2242, 10299, 1920, 3760, 20471, 4189, 2007, 2149, 17, 3253, 17913, 25722, 8871, 1922, 1920, 3067, 18, 3555, 12, 56, 33, 3858, 13, 3]}, "items": [{"id": "p_5109", "content": "Alfentanil [SEP] A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recov", "score": 1, "type": null, "tokenized_content": [2, 17913, 25722, 3, 43, 3662, 17, 8290, 9384, 16111, 1930, 14501, 10533, 1927, 20311, 18, 2176, 9300, 1925, 3120, 3833, 14501, 2495, 1930, 5867, 29326, 1020, 3]}]}
{"query": {"id": "q_5110", "content": "medetomidine [SEP] The highly-selective alpha-2 adrenergic agonist dexmedetomidine (D-MED) is capable of inducing muscle flaccidity and anesthesia", "tokenized_content": [2, 2242, 24840, 3, 1920, 3626, 17, 5328, 4595, 17, 22, 13672, 7829, 26854, 12, 46, 17, 2242, 13, 1977, 7131, 1927, 7834, 3760, 2300, 3339, 5212, 1930, 8871, 3]}, "items": [{"id": "p_5110", "content": "Medetomidine [SEP] An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is", "score": 1, "type": null, "tokenized_content": [2, 2242, 24840, 3, 1925, 7829, 1927, 4086, 16, 13672, 4595, 17, 22, 1988, 1977, 2251, 1922, 15748, 5380, 1958, 2496, 14501, 1930, 28514, 3879, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_5111", "content": "idazoxan [SEP] D [30 micrograms/kg] and the central-acting alpha-2 antagonist, idazoxan [10 mg/kg]; 5) D-MED [30 micrograms/kg] and the peripheral-acti", "tokenized_content": [2, 29930, 13642, 11414, 1022, 3, 46, 37, 2627, 13362, 19, 3621, 39, 1930, 1920, 4101, 17, 8290, 4595, 17, 22, 8151, 16, 29930, 13642, 11414, 1022, 37, 2119, 2786, 19, 3]}, "items": [{"id": "p_5111", "content": "Idazoxan [SEP] A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29930, 13642, 11414, 1022, 3, 43, 19225, 7408, 18760, 17, 4624, 16045, 1988, 2258, 4595, 17, 22, 25090, 8151, 2455, 18, 3]}]}
{"query": {"id": "q_5112", "content": "DG-5128 [SEP] [30 micrograms/kg] and the peripheral-acting alpha-2 antagonist DG-5128 [10 mg/kg], or; 6) saline. Baseline electromyographic activity ", "tokenized_content": [2, 9665, 17, 20094, 1025, 3, 37, 2627, 13362, 19, 3621, 39, 1930, 1920, 5009, 17, 8290, 4595, 17, 22, 8151, 9665, 17, 20094, 1025, 37, 2119, 2786, 19, 3621, 39, 3]}, "items": [{"id": "p_5112", "content": "midaglizole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3953, 15915, 2061, 2456, 3, 3]}]}
{"query": {"id": "q_5113", "content": "ALF [SEP] ter drug treatment. Each rat was then injected with alfentanil (ALF, 0.5 mg/kg sc). ALF injection resulted in a marked increase in ", "tokenized_content": [2, 17913, 3, 6005, 2838, 2311, 18, 2362, 3067, 1982, 2759, 5624, 1956, 17913, 25722, 12, 17913, 16, 20, 18, 25, 2786, 19, 3621, 2160, 13, 18, 17913, 4107, 4306, 1922, 3]}, "items": [{"id": "p_5113", "content": "Alfentanil [SEP] A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recov", "score": 1, "type": null, "tokenized_content": [2, 17913, 25722, 3, 43, 3662, 17, 8290, 9384, 16111, 1930, 14501, 10533, 1927, 20311, 18, 2176, 9300, 1925, 3120, 3833, 14501, 2495, 1930, 5867, 29326, 1020, 3]}]}
{"query": {"id": "q_5114", "content": "akinetic [SEP] not given any opiate. The high-dose D-MED animals were flaccid, akinetic, and lacked a startle response during the entire experimental p", "tokenized_content": [2, 26162, 3023, 3, 2084, 3258, 2967, 27059, 18, 1920, 2149, 17, 3253, 46, 17, 2242, 3555, 1985, 2300, 3339, 1960, 16, 26162, 3023, 16, 1930, 15115, 43, 21866, 2644, 2409, 3]}, "items": [{"id": "p_5114", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_5115", "content": "startle [SEP] he high-dose D-MED animals were flaccid, akinetic, and lacked a startle response during the entire experimental period.(ABSTRACT TRUNCA", "tokenized_content": [2, 21866, 3, 2234, 2149, 17, 3253, 46, 17, 2242, 3555, 1985, 2300, 3339, 1960, 16, 26162, 3023, 16, 1930, 15115, 43, 21866, 2644, 2409, 1920, 5346, 3599, 3047, 18, 12, 3]}, "items": [{"id": "p_5115", "content": "Reflex, Abnormal [SEP] An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased,", "score": 1, "type": null, "tokenized_content": [2, 11573, 16, 4552, 3, 1925, 4552, 2644, 1942, 43, 5794, 3730, 1942, 1920, 6893, 4178, 1927, 1920, 7580, 2433, 18, 2052, 2278, 6132, 1920, 2386, 1927, 2502, 16, 3]}]}
{"query": {"id": "q_5116", "content": "Seizure [SEP] Seizure activity with imipenem therapy: incidence and risk factors.", "tokenized_content": [2, 11015, 3, 11015, 2455, 1956, 30309, 3181, 30, 4332, 1930, 2565, 2790, 18, 3]}, "items": [{"id": "p_5116", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5117", "content": "imipenem [SEP] Seizure activity with imipenem therapy: incidence and risk factors.", "tokenized_content": [2, 30309, 3, 11015, 2455, 1956, 30309, 3181, 30, 4332, 1930, 2565, 2790, 18, 3]}, "items": [{"id": "p_5117", "content": "Imipenem [SEP] Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and", "score": 1, "type": null, "tokenized_content": [2, 30309, 3, 8762, 18801, 4905, 4116, 2002, 7566, 11496, 14930, 3665, 1988, 2258, 43, 4743, 5648, 1927, 13021, 2455, 3316, 8604, 17, 3136, 1930, 8604, 17, 2843, 11251, 1930, 3]}]}
{"query": {"id": "q_5118", "content": "cerebral vascular accident [SEP] Two elderly patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed", "tokenized_content": [2, 6329, 4541, 17713, 3, 2288, 7354, 2132, 1956, 43, 4403, 1927, 3108, 6329, 4541, 17713, 12, 5519, 1019, 13, 2014, 4469, 7176, 1930, 2239, 3095, 1927, 4604, 2573, 3530, 3]}, "items": [{"id": "p_5118", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_5119", "content": "CVA [SEP] y patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seiz", "tokenized_content": [2, 5519, 1019, 3, 67, 2132, 1956, 43, 4403, 1927, 3108, 6329, 4541, 17713, 12, 5519, 1019, 13, 2014, 4469, 7176, 1930, 2239, 3095, 1927, 4604, 2573, 3530, 7563, 3]}, "items": [{"id": "p_5119", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_5120", "content": "head trauma [SEP] ts with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while recei", "tokenized_content": [2, 4469, 7176, 3, 4894, 1956, 43, 4403, 1927, 3108, 6329, 4541, 17713, 12, 5519, 1019, 13, 2014, 4469, 7176, 1930, 2239, 3095, 1927, 4604, 2573, 3530, 10060, 2679, 3169, 1033, 3]}, "items": [{"id": "p_5120", "content": "Craniocerebral Trauma [SEP] Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structure", "score": 1, "type": null, "tokenized_content": [2, 21204, 2337, 13495, 7317, 7176, 3, 10242, 8209, 5884, 1920, 17586, 1989, 1930, 12179, 4061, 12, 51, 18, 47, 18, 16, 3068, 31, 13598, 12014, 31, 10286, 1918, 31, 1930, 2303, 3170, 3]}]}
{"query": {"id": "q_5121", "content": "renal disease [SEP] ebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while receiving maximum doses of imipenem/ci", "tokenized_content": [2, 4604, 2573, 3, 6560, 7317, 4541, 17713, 12, 5519, 1019, 13, 2014, 4469, 7176, 1930, 2239, 3095, 1927, 4604, 2573, 3530, 10060, 2679, 5962, 4419, 5312, 1927, 30309, 19, 3371, 3]}, "items": [{"id": "p_5121", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5122", "content": "seizures [SEP] (CVA) or head trauma and no evidence of renal disease developed seizures while receiving maximum doses of imipenem/cilastatin. Neither p", "tokenized_content": [2, 10060, 3, 12, 5519, 1019, 13, 2014, 4469, 7176, 1930, 2239, 3095, 1927, 4604, 2573, 3530, 10060, 2679, 5962, 4419, 5312, 1927, 30309, 19, 12127, 11680, 18, 7132, 58, 3]}, "items": [{"id": "p_5122", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5123", "content": "imipenem/cilastatin [SEP] nal disease developed seizures while receiving maximum doses of imipenem/cilastatin. Neither patient had reported previous seizures or seizure-like", "tokenized_content": [2, 30309, 19, 12127, 11680, 3, 13120, 2573, 3530, 10060, 2679, 5962, 4419, 5312, 1927, 30309, 19, 12127, 11680, 18, 7132, 2774, 2430, 2568, 2555, 10060, 2014, 11015, 17, 3189, 3]}, "items": [{"id": "p_5123", "content": "cilastatin, imipenem drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12127, 11680, 16, 30309, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_5124", "content": "seizure [SEP] (CVA) or head trauma and no evidence of renal disease developed seizures while receiving maximum doses of imipenem/cilastatin. Neither ", "tokenized_content": [2, 11015, 3, 12, 5519, 1019, 13, 2014, 4469, 7176, 1930, 2239, 3095, 1927, 4604, 2573, 3530, 10060, 2679, 5962, 4419, 5312, 1927, 30309, 19, 12127, 11680, 18, 7132, 3]}, "items": [{"id": "p_5124", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5125", "content": "phenytoin [SEP]  agents. All seizures were controlled with therapeutic doses of phenytoin. Both patients had received maximum doses of other beta-lactam ", "tokenized_content": [2, 3037, 30177, 3, 4820, 18, 2136, 10060, 1985, 4642, 1956, 4272, 5312, 1927, 3037, 30177, 18, 2321, 2132, 2430, 4004, 4419, 5312, 1927, 2303, 4666, 17, 15294, 3]}, "items": [{"id": "p_5125", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_5126", "content": "beta-lactam [SEP] of phenytoin. Both patients had received maximum doses of other beta-lactam antibiotics without evidence of seizure activity.", "tokenized_content": [2, 4666, 17, 15294, 3, 1927, 3037, 30177, 18, 2321, 2132, 2430, 4004, 4419, 5312, 1927, 2303, 4666, 17, 15294, 7560, 2979, 3095, 1927, 11015, 2455, 18, 3]}, "items": [{"id": "p_5126", "content": "beta-Lactams [SEP] Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 15294, 1036, 3, 3006, 17, 30261, 9821, 13601, 1036, 16, 4534, 3171, 1958, 1920, 9957, 1036, 2454, 1990, 43, 8876, 3143, 1037, 17, 27225, 11300, 2053, 16, 1966, 2486, 1966, 1920, 25091, 2925, 2454, 3]}]}
{"query": {"id": "q_5127", "content": "streptozotocin [SEP] se or prevent the changes in urinary bladder function caused by streptozotocin-induced diabetes mellitus.", "tokenized_content": [2, 26492, 3, 2058, 2014, 4625, 1920, 2840, 1922, 7075, 7821, 2347, 4189, 2007, 26492, 17, 2719, 4032, 9695, 18, 3]}, "items": [{"id": "p_5127", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_5128", "content": "diabetes mellitus [SEP] es in urinary bladder function caused by streptozotocin-induced diabetes mellitus.", "tokenized_content": [2, 4032, 9695, 3, 2376, 1922, 7075, 7821, 2347, 4189, 2007, 26492, 17, 2719, 4032, 9695, 18, 3]}, "items": [{"id": "p_5128", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_5129", "content": "streptozotocin [SEP] n treatment on in vivo and in vitro urinary bladder function in streptozotocin-diabetic rats were investigated. 2. Diabetes of 2 months durati", "tokenized_content": [2, 26492, 3, 56, 2311, 1990, 1922, 3597, 1930, 1922, 3596, 7075, 7821, 2347, 1922, 26492, 17, 6152, 3615, 1985, 3845, 18, 22, 18, 4032, 1927, 22, 3221, 25389, 1914, 3]}, "items": [{"id": "p_5129", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_5130", "content": "diabetic [SEP] in vivo and in vitro urinary bladder function in streptozotocin-diabetic rats were investigated. 2. Diabetes of 2 months duration result", "tokenized_content": [2, 6152, 3, 1922, 3597, 1930, 1922, 3596, 7075, 7821, 2347, 1922, 26492, 17, 6152, 3615, 1985, 3845, 18, 22, 18, 4032, 1927, 22, 3221, 4392, 3211, 3]}, "items": [{"id": "p_5130", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_5131", "content": "Diabetes [SEP]  function in streptozotocin-diabetic rats were investigated. 2. Diabetes of 2 months duration resulted in decreases in body weight and i", "tokenized_content": [2, 4032, 3, 2347, 1922, 26492, 17, 6152, 3615, 1985, 3845, 18, 22, 18, 4032, 1927, 22, 3221, 4392, 4306, 1922, 6386, 1922, 3362, 3388, 1930, 51, 3]}, "items": [{"id": "p_5131", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_5132", "content": "ATP [SEP] of bladder body strips from diabetic rats to nerve stimulation, ATP, and bethanechol. 4. Diabetes of 4 months duration also resulte", "tokenized_content": [2, 4498, 3, 1927, 7821, 3362, 18721, 2037, 6152, 3615, 1942, 5507, 4177, 16, 4498, 16, 1930, 2143, 15409, 2305, 1945, 18, 24, 18, 4032, 1927, 24, 3221, 4392, 2222, 3211, 3]}, "items": [{"id": "p_5132", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_5133", "content": "bethanechol [SEP] r body strips from diabetic rats to nerve stimulation, ATP, and bethanechol. 4. Diabetes of 4 months duration also resulted in decreases in", "tokenized_content": [2, 2143, 15409, 2305, 1945, 3, 60, 3362, 18721, 2037, 6152, 3615, 1942, 5507, 4177, 16, 4498, 16, 1930, 2143, 15409, 2305, 1945, 18, 24, 18, 4032, 1927, 24, 3221, 4392, 3]}, "items": [{"id": "p_5133", "content": "Bethanechol [SEP] A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone,", "score": 1, "type": null, "tokenized_content": [2, 2143, 15409, 2305, 1945, 3, 43, 11240, 7222, 9046, 20318, 7829, 1956, 2239, 20239, 2564, 18, 2143, 15409, 2305, 1945, 1977, 4933, 2251, 1942, 2760, 6689, 3760, 11020, 16, 3]}]}
{"query": {"id": "q_5134", "content": "diabetes [SEP] 6. The data indicate that the effects of streptozotocin-induced diabetes on urinary bladder function are both prevented and reversed by ", "tokenized_content": [2, 4032, 3, 26, 18, 1920, 2230, 3579, 1988, 1920, 2564, 1927, 26492, 17, 2719, 4032, 1990, 7075, 7821, 2347, 2032, 2321, 8715, 1930, 9432, 2007, 3]}, "items": [{"id": "p_5134", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_5135", "content": "hypertension [SEP] Delayed institution of hypertension during focal cerebral ischemia: effect on brain edema.", "tokenized_content": [2, 5579, 3, 7083, 5115, 1927, 5579, 2409, 8083, 6329, 7716, 30, 2495, 1990, 3068, 10144, 18, 3]}, "items": [{"id": "p_5135", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5136", "content": "cerebral ischemia [SEP] Delayed institution of hypertension during focal cerebral ischemia: effect on brain edema.", "tokenized_content": [2, 6329, 7716, 3, 7083, 5115, 1927, 5579, 2409, 8083, 6329, 7716, 30, 2495, 1990, 3068, 10144, 18, 3]}, "items": [{"id": "p_5136", "content": "Brain Ischemia [SEP] Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs ", "score": 1, "type": null, "tokenized_content": [2, 3068, 7716, 3, 6579, 3378, 1927, 2877, 3426, 1942, 3068, 2960, 2810, 1942, 6624, 10849, 2014, 5510, 26497, 1915, 9049, 18, 2052, 5467, 5110, 3]}]}
{"query": {"id": "q_5137", "content": "brain edema [SEP] ution of hypertension during focal cerebral ischemia: effect on brain edema.", "tokenized_content": [2, 3068, 10144, 3, 21472, 1916, 1927, 5579, 2409, 8083, 6329, 7716, 30, 2495, 1990, 3068, 10144, 18, 3]}, "items": [{"id": "p_5137", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_5138", "content": "hypertension [SEP] The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery o", "tokenized_content": [2, 5579, 3, 1920, 2495, 1927, 2719, 5579, 5381, 1007, 2256, 43, 22, 17, 50, 4989, 2894, 5576, 6329, 5511, 57, 3]}, "items": [{"id": "p_5138", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5139", "content": "middle cerebral artery occlusion [SEP]  of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was st", "tokenized_content": [2, 5576, 6329, 5511, 10543, 3, 1927, 2719, 5579, 5381, 1007, 2256, 43, 22, 17, 50, 4989, 2894, 5576, 6329, 5511, 10543, 12, 22352, 13, 1990, 3068, 10144, 3337, 1930, 27816, 3]}, "items": [{"id": "p_5139", "content": "Infarction, Middle Cerebral Artery [SEP] NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CE", "score": 1, "type": null, "tokenized_content": [2, 8358, 16, 5576, 6329, 5511, 3, 7476, 6966, 1922, 1920, 5576, 6329, 5511, 3282, 2433, 2154, 21490, 2877, 1942, 1920, 5346, 5347, 6082, 1927, 2362, 5827, 3]}]}
{"query": {"id": "q_5140", "content": "MCAO [SEP] d after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied.", "tokenized_content": [2, 22352, 3, 46, 2256, 43, 22, 17, 50, 4989, 2894, 5576, 6329, 5511, 10543, 12, 22352, 13, 1990, 3068, 10144, 3337, 1930, 27816, 4047, 1982, 3942, 18, 3]}, "items": [{"id": "p_5140", "content": "Infarction, Middle Cerebral Artery [SEP] NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CE", "score": 1, "type": null, "tokenized_content": [2, 8358, 16, 5576, 6329, 5511, 3, 7476, 6966, 1922, 1920, 5576, 6329, 5511, 3282, 2433, 2154, 21490, 2877, 1942, 1920, 5346, 5347, 6082, 1927, 2362, 5827, 3]}]}
{"query": {"id": "q_5141", "content": "brain edema [SEP]  2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isofluran", "tokenized_content": [2, 3068, 10144, 3, 22, 17, 50, 4989, 2894, 5576, 6329, 5511, 10543, 12, 22352, 13, 1990, 3068, 10144, 3337, 1930, 27816, 4047, 1982, 3942, 18, 2441, 4911, 12353, 1928, 3]}, "items": [{"id": "p_5141", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_5142", "content": "isoflurane [SEP] ain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was o", "tokenized_content": [2, 15362, 3, 9798, 1022, 10144, 3337, 1930, 27816, 4047, 1982, 3942, 18, 2441, 15362, 8871, 16, 1920, 14035, 1927, 2607, 12753, 11706, 3615, 1982, 57, 3]}, "items": [{"id": "p_5142", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_5143", "content": "hypertensive [SEP] udied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arter", "tokenized_content": [2, 11706, 3, 19803, 2177, 18, 2441, 15362, 8871, 16, 1920, 14035, 1927, 2607, 12753, 11706, 3615, 1982, 22335, 18, 1922, 1920, 2285, 2210, 12, 56, 33, 27, 13, 16, 1920, 3]}, "items": [{"id": "p_5143", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5144", "content": "ischemia [SEP] ere sectioned along coronal planes spanning the distribution of ischemia produced by MCAO. Specific gravity (SG) was determined in the s", "tokenized_content": [2, 7716, 3, 22561, 17874, 4231, 13110, 16573, 13346, 1920, 3282, 1927, 7716, 4152, 2007, 22352, 18, 2487, 18158, 12, 10075, 13, 1982, 3180, 1922, 1920, 61, 3]}, "items": [{"id": "p_5144", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_5145", "content": "ischemic [SEP] ortex and in two sites in the cortex (core and periphery of the ischemic territory). The extent of neuronal injury was determined by 2,3", "tokenized_content": [2, 7427, 3, 2014, 4583, 1930, 1922, 2288, 3402, 1922, 1920, 4997, 12, 4728, 1930, 13119, 1927, 1920, 7427, 20217, 13, 18, 1920, 5064, 1927, 5121, 4047, 1982, 3180, 2007, 22, 3]}, "items": [{"id": "p_5145", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_5146", "content": "neuronal injury [SEP] x (core and periphery of the ischemic territory). The extent of neuronal injury was determined by 2,3,5-triphenyltetrazolium staining. In the i", "tokenized_content": [2, 5121, 4047, 3, 66, 12, 4728, 1930, 13119, 1927, 1920, 7427, 20217, 13, 18, 1920, 5064, 1927, 5121, 4047, 1982, 3180, 2007, 22, 16, 23, 16, 25, 17, 14051, 8033, 3]}, "items": [{"id": "p_5146", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_5147", "content": "2,3,5-triphenyltetrazolium [SEP] mic territory). The extent of neuronal injury was determined by 2,3,5-triphenyltetrazolium staining. In the ischemic core, there was no difference in SG i", "tokenized_content": [2, 22, 16, 23, 16, 25, 17, 14051, 8033, 28959, 17396, 3, 2206, 20217, 13, 18, 1920, 5064, 1927, 5121, 4047, 1982, 3180, 2007, 22, 16, 23, 16, 25, 17, 14051, 3]}, "items": [{"id": "p_5147", "content": "triphenyltetrazolium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14051, 8033, 28959, 17396, 3, 3]}]}
{"query": {"id": "q_5148", "content": "edema [SEP] elay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isofluran", "tokenized_content": [2, 10144, 3, 2349, 2050, 2894, 5576, 6329, 5511, 10543, 12, 22352, 13, 1990, 3068, 10144, 3337, 1930, 27816, 4047, 1982, 3942, 18, 2441, 4911, 12353, 1928, 3]}, "items": [{"id": "p_5148", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_5149", "content": "phenylephrine [SEP]  +/- 3% vs 21 +/- 2%, P less than 0.05). The data indicate that phenylephrine-induced hypertension instituted 2 h after MCAO does not aggrava", "tokenized_content": [2, 27053, 3, 15, 19, 17, 23, 9, 3201, 2900, 15, 19, 17, 22, 9, 16, 58, 2941, 2254, 20, 18, 2914, 13, 18, 1920, 2230, 3579, 1988, 27053, 17, 2719, 3]}, "items": [{"id": "p_5149", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_5150", "content": "neuronal dysfunction [SEP] chemic territory, and that it reduces the area of histochemical neuronal dysfunction.", "tokenized_content": [2, 5121, 5273, 3, 2975, 1935, 20217, 16, 1930, 1988, 2176, 7268, 1920, 3403, 1927, 27816, 5121, 5273, 18, 3]}, "items": [{"id": "p_5150", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_5151", "content": "Amiodarone [SEP] Amiodarone pulmonary toxicity.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 15665, 25033, 2830, 1021, 5352, 5532, 18, 3]}, "items": [{"id": "p_5151", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_5152", "content": "pulmonary toxicity [SEP] Amiodarone pulmonary toxicity.", "tokenized_content": [2, 5352, 5532, 3, 15665, 25033, 2830, 1021, 5352, 5532, 18, 3]}, "items": [{"id": "p_5152", "content": "Lung Diseases [SEP] Pathological processes involving any part of the LUNG.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3614, 3902, 3, 6598, 4028, 5884, 2967, 3131, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_5153", "content": "Amiodarone [SEP] Amiodarone is an effective antiarrhythmic agent whose utility is limited b", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 15665, 25033, 2830, 1021, 1977, 1925, 3655, 2246, 23246, 4913, 5899, 6098, 8531, 1977, 3892, 44, 3]}, "items": [{"id": "p_5153", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_5154", "content": "pneumonitis [SEP] ity is limited by many side-effects, the most problematic being pneumonitis. The pulmonary toxicity of amiodarone is thought to result from", "tokenized_content": [2, 24560, 3678, 3, 2176, 1012, 1977, 3892, 2007, 3086, 4159, 17, 2564, 16, 1920, 2501, 13624, 3301, 24560, 3678, 18, 1920, 5352, 5532, 1927, 15665, 25033, 2830, 1021, 1977, 6212, 3]}, "items": [{"id": "p_5154", "content": "Pneumonia [SEP] Inflammation of any part, segment or lobe, of the lung parenchyma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7868, 3, 4531, 1927, 2967, 3131, 16, 5367, 2014, 9581, 16, 1927, 1920, 3614, 15214, 18, 3]}]}
{"query": {"id": "q_5155", "content": "pulmonary toxicity [SEP]  many side-effects, the most problematic being pneumonitis. The pulmonary toxicity of amiodarone is thought to result from direct injury related t", "tokenized_content": [2, 5352, 5532, 3, 3086, 4159, 17, 2564, 16, 1920, 2501, 13624, 3301, 24560, 3678, 18, 1920, 5352, 5532, 1927, 15665, 25033, 2830, 1021, 1977, 6212, 1942, 3211, 2037, 3083, 4047, 3]}, "items": [{"id": "p_5155", "content": "Lung Diseases [SEP] Pathological processes involving any part of the LUNG.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3614, 3902, 3, 6598, 4028, 5884, 2967, 3131, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_5156", "content": "amiodarone [SEP] e most problematic being pneumonitis. The pulmonary toxicity of amiodarone is thought to result from direct injury related to the intracel", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 47, 2501, 13624, 3301, 24560, 3678, 18, 1920, 5352, 5532, 1927, 15665, 25033, 2830, 1021, 1977, 6212, 1942, 3211, 2037, 3083, 4047, 2712, 1942, 1920, 3]}, "items": [{"id": "p_5156", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_5157", "content": "hypersensitivity [SEP]  intracellular accumulation of phospholipid and T cell-mediated hypersensitivity pneumonitis. The clinical and radiographic features of amiodaro", "tokenized_content": [2, 14625, 3, 4776, 4858, 1927, 14608, 1930, 62, 2024, 17, 3434, 14625, 24560, 3678, 18, 1920, 2535, 1930, 12859, 4075, 1927, 15665, 25033, 1931, 3]}, "items": [{"id": "p_5157", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_5158", "content": "pneumonitis [SEP] ity is limited by many side-effects, the most problematic being pneumonitis. The pulmonary toxicity of amiodarone is thought to result from", "tokenized_content": [2, 24560, 3678, 3, 2176, 1012, 1977, 3892, 2007, 3086, 4159, 17, 2564, 16, 1920, 2501, 13624, 3301, 24560, 3678, 18, 1920, 5352, 5532, 1927, 15665, 25033, 2830, 1021, 1977, 6212, 3]}, "items": [{"id": "p_5158", "content": "Alveolitis, Extrinsic Allergic [SEP] A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitizati", "score": 1, "type": null, "tokenized_content": [2, 23405, 8436, 3600, 16, 16074, 10519, 3, 43, 3059, 11584, 3614, 2573, 4189, 2007, 14625, 5298, 1927, 5352, 23405, 8436, 2256, 14728, 1927, 1930, 3532, 12813, 1914, 3]}]}
{"query": {"id": "q_5159", "content": "heart failure [SEP] . The diagnosis depends on exclusion of other entities, such as heart failure, infection, and malignancy. While withdrawal of amiodarone lead", "tokenized_content": [2, 4003, 4574, 3, 18, 1920, 3574, 7315, 1990, 7901, 1927, 2303, 14977, 16, 2427, 1966, 4003, 4574, 16, 2909, 16, 1930, 10248, 18, 2679, 9594, 1927, 15665, 25033, 2830, 1021, 3]}, "items": [{"id": "p_5159", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_5160", "content": "infection [SEP]  depends on exclusion of other entities, such as heart failure, infection, and malignancy. While withdrawal of amiodarone leads to clinic", "tokenized_content": [2, 2909, 3, 7315, 1990, 7901, 1927, 2303, 14977, 16, 2427, 1966, 4003, 4574, 16, 2909, 16, 1930, 10248, 18, 2679, 9594, 1927, 15665, 25033, 2830, 1021, 5029, 1942, 6248, 3]}, "items": [{"id": "p_5160", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_5161", "content": "malignancy [SEP] lusion of other entities, such as heart failure, infection, and malignancy. While withdrawal of amiodarone leads to clinical improvement i", "tokenized_content": [2, 10248, 3, 10908, 12924, 1916, 1927, 2303, 14977, 16, 2427, 1966, 4003, 4574, 16, 2909, 16, 1930, 10248, 18, 2679, 9594, 1927, 15665, 25033, 2830, 1021, 5029, 1942, 2535, 4990, 3]}, "items": [{"id": "p_5161", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5162", "content": "steroid [SEP] not always possible or advisable. Dose reduction or concomitant steroid therapy may have a role in selected patients.", "tokenized_content": [2, 9507, 3, 2084, 6789, 3216, 2014, 14683, 2115, 18, 3253, 3378, 2014, 8537, 9507, 3181, 2278, 2162, 43, 2770, 1922, 3790, 2132, 18, 3]}, "items": [{"id": "p_5162", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_5163", "content": "proteinuria [SEP] Light chain proteinuria and cellular mediated immunity in rifampin treated patients wit", "tokenized_content": [2, 15831, 3, 3696, 4659, 15831, 1930, 3689, 3434, 7611, 1922, 18332, 1921, 2868, 2132, 16086, 3]}, "items": [{"id": "p_5163", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5164", "content": "rifampin [SEP] Light chain proteinuria and cellular mediated immunity in rifampin treated patients with tuberculosis.", "tokenized_content": [2, 18332, 1921, 3, 3696, 4659, 15831, 1930, 3689, 3434, 7611, 1922, 18332, 1921, 2868, 2132, 1956, 8449, 18, 3]}, "items": [{"id": "p_5164", "content": "Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag", "score": 1, "type": null, "tokenized_content": [2, 18332, 1921, 3, 43, 8762, 18801, 4905, 4116, 2002, 7267, 4152, 2037, 22874, 16241, 1033, 18, 2176, 2258, 43, 4949, 13021, 5648, 16, 2710, 2455, 2260, 3]}]}
{"query": {"id": "q_5165", "content": "tuberculosis [SEP] nd cellular mediated immunity in rifampin treated patients with tuberculosis.", "tokenized_content": [2, 8449, 3, 8026, 3689, 3434, 7611, 1922, 18332, 1921, 2868, 2132, 1956, 8449, 18, 3]}, "items": [{"id": "p_5165", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_5166", "content": "proteinuria [SEP] Light chain proteinuria was found in 9 of 17 tuberculosis patients treated with rifampi", "tokenized_content": [2, 15831, 3, 3696, 4659, 15831, 1982, 2435, 1922, 29, 1927, 2752, 8449, 2132, 2868, 1956, 18332, 1033, 3]}, "items": [{"id": "p_5166", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5167", "content": "tuberculosis [SEP] Light chain proteinuria was found in 9 of 17 tuberculosis patients treated with rifampin. Concomitant assay of cellular m", "tokenized_content": [2, 8449, 3, 3696, 4659, 15831, 1982, 2435, 1922, 29, 1927, 2752, 8449, 2132, 2868, 1956, 18332, 1921, 18, 8537, 3381, 1927, 3689, 55, 3]}, "items": [{"id": "p_5167", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_5168", "content": "rifampin [SEP] einuria was found in 9 of 17 tuberculosis patients treated with rifampin. Concomitant assay of cellular mediated immunity in these patie", "tokenized_content": [2, 18332, 1921, 3, 16101, 1022, 8754, 1982, 2435, 1922, 29, 1927, 2752, 8449, 2132, 2868, 1956, 18332, 1921, 18, 8537, 3381, 1927, 3689, 3434, 7611, 1922, 2144, 2091, 1021, 3]}, "items": [{"id": "p_5168", "content": "Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag", "score": 1, "type": null, "tokenized_content": [2, 18332, 1921, 3, 43, 8762, 18801, 4905, 4116, 2002, 7267, 4152, 2037, 22874, 16241, 1033, 18, 2176, 2258, 43, 4949, 13021, 5648, 16, 2710, 2455, 2260, 3]}]}
{"query": {"id": "q_5169", "content": "tuberculous [SEP] nts to phytomitogen (PHA-P). as well as of those of seven other tuberculous patients. This last finding may be related to time of testing a", "tokenized_content": [2, 7687, 17918, 3, 17969, 1942, 25512, 4739, 2404, 12, 18421, 17, 58, 13, 18, 1966, 2486, 1966, 1927, 2690, 1927, 5260, 2303, 7687, 17918, 2132, 18, 2052, 4691, 2849, 2278, 3]}, "items": [{"id": "p_5169", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_5170", "content": "potassium [SEP] Initial potassium loss and hypokalaemia during chlorthalidone administration in p", "tokenized_content": [2, 9057, 3, 3754, 9057, 3257, 1930, 14395, 7640, 5148, 3847, 2409, 4891, 8025, 15726, 4183, 1922, 58, 3]}, "items": [{"id": "p_5170", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_5171", "content": "hypokalaemia [SEP] Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential", "tokenized_content": [2, 14395, 7640, 5148, 3847, 3, 3754, 9057, 3257, 1930, 14395, 7640, 5148, 3847, 2409, 4891, 8025, 15726, 4183, 1922, 2132, 1956, 4415, 3]}, "items": [{"id": "p_5171", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_5172", "content": "chlorthalidone [SEP] Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the inf", "tokenized_content": [2, 4891, 8025, 15726, 3, 3754, 9057, 3257, 1930, 14395, 7640, 5148, 3847, 2409, 4891, 8025, 15726, 4183, 1922, 2132, 1956, 4415, 5579, 30, 1920, 2122, 3]}, "items": [{"id": "p_5172", "content": "Chlorthalidone [SEP] A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4891, 8025, 15726, 3, 43, 18536, 19028, 12502, 16408, 1021, 17, 19686, 29899, 1988, 7462, 4575, 9213, 4517, 1942, 43, 19225, 17616, 3965, 2386, 18, 2176, 1977, 3311, 43, 27225, 2261, 17, 3189, 26829, 18, 3]}]}
{"query": {"id": "q_5173", "content": "hypertension [SEP] during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction.", "tokenized_content": [2, 5579, 3, 2409, 4891, 8025, 15726, 4183, 1922, 2132, 1956, 4415, 5579, 30, 1920, 4039, 1927, 6096, 5227, 7587, 18, 3]}, "items": [{"id": "p_5173", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5174", "content": "sodium [SEP]  patients with essential hypertension: the influence of dietary sodium restriction.", "tokenized_content": [2, 5227, 3, 2132, 1956, 4415, 5579, 30, 1920, 4039, 1927, 6096, 5227, 7587, 18, 3]}, "items": [{"id": "p_5174", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_5175", "content": "potassium [SEP] To investigate the initial potassium loss and development of hypokalaemia during the administration ", "tokenized_content": [2, 9057, 3, 1942, 4482, 1920, 3754, 9057, 3257, 1930, 2740, 1927, 14395, 7640, 5148, 3847, 2409, 1920, 4183, 3]}, "items": [{"id": "p_5175", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_5176", "content": "hypokalaemia [SEP] To investigate the initial potassium loss and development of hypokalaemia during the administration of an oral diuretic, metabolic balanc", "tokenized_content": [2, 14395, 7640, 5148, 3847, 3, 1942, 4482, 1920, 3754, 9057, 3257, 1930, 2740, 1927, 14395, 7640, 5148, 3847, 2409, 1920, 4183, 1927, 1925, 4726, 26829, 16, 4487, 4641, 2412, 3]}, "items": [{"id": "p_5176", "content": "Hypokalemia [SEP] Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointest", "score": 1, "type": null, "tokenized_content": [2, 14395, 7640, 1952, 6026, 3, 20756, 2330, 9057, 3110, 1922, 1920, 2877, 18, 2176, 2278, 3211, 2037, 9057, 3257, 2007, 4604, 5512, 2014, 2007, 1920, 6858, 2879, 2158, 3]}]}
{"query": {"id": "q_5177", "content": "hypertension [SEP] c balance studies were performed in ten patients with essential hypertension who had shown hypokalaemia under prior oral diuretic treatment.", "tokenized_content": [2, 5579, 3, 45, 6766, 2351, 1985, 2593, 1922, 5656, 2132, 1956, 4415, 5579, 2746, 2430, 2522, 14395, 7640, 5148, 3847, 2441, 3432, 4726, 26829, 2311, 18, 3]}, "items": [{"id": "p_5177", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5178", "content": "Chlorthalidone [SEP] who had shown hypokalaemia under prior oral diuretic treatment. Chlorthalidone (50 mg daily) was given for 14 days. Six patients received a no", "tokenized_content": [2, 4891, 8025, 15726, 3, 2746, 2430, 2522, 14395, 7640, 5148, 3847, 2441, 3432, 4726, 26829, 2311, 18, 4891, 8025, 15726, 12, 2761, 2786, 4692, 13, 1982, 3258, 1958, 2607, 3000, 3]}, "items": [{"id": "p_5178", "content": "Chlorthalidone [SEP] A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4891, 8025, 15726, 3, 43, 18536, 19028, 12502, 16408, 1021, 17, 19686, 29899, 1988, 7462, 4575, 9213, 4517, 1942, 43, 19225, 17616, 3965, 2386, 18, 2176, 1977, 3311, 43, 27225, 2261, 17, 3189, 26829, 18, 3]}]}
{"query": {"id": "q_5179", "content": "sodium [SEP] mg daily) was given for 14 days. Six patients received a normal-sodium diet and four a low-sodium (17 mmol/day) diet. All patients had", "tokenized_content": [2, 5227, 3, 2786, 4692, 13, 1982, 3258, 1958, 2607, 3000, 18, 3798, 2132, 4004, 43, 2791, 17, 5227, 3986, 1930, 3006, 43, 2330, 17, 5227, 12, 2752, 6397, 19, 3007, 3]}, "items": [{"id": "p_5179", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_5180", "content": "aldosterone [SEP] yte balances, weight, bromide space, plasma renin activity, and aldosterone secretion rate were measured. In both groups a potassium defici", "tokenized_content": [2, 16944, 3, 24412, 1021, 6766, 1036, 16, 3388, 16, 13788, 5230, 16, 3582, 16306, 2455, 16, 1930, 16944, 5512, 2769, 1985, 3045, 18, 1922, 2321, 2671, 43, 9057, 6428, 1033, 3]}, "items": [{"id": "p_5180", "content": "Aldosterone [SEP] A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodiu", "score": 1, "type": null, "tokenized_content": [2, 16944, 3, 43, 6365, 8366, 2007, 1920, 10651, 4997, 1988, 7014, 15428, 1930, 3224, 6766, 2007, 3605, 1920, 4604, 7521, 1927, 4546, 1033, 1032, 3]}]}
{"query": {"id": "q_5181", "content": "angiotensin [SEP] otassium loss, presumably by an increased activity of the renin-angiotensin-aldosterone system, while sodium delivery to the distal renal t", "tokenized_content": [2, 10814, 3, 28495, 5590, 2457, 3257, 16, 9968, 2007, 1925, 2502, 2455, 1927, 1920, 16306, 17, 10814, 17, 16944, 2433, 16, 2679, 5227, 4868, 1942, 1920, 6583, 4604, 62, 3]}, "items": [{"id": "p_5181", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_5182", "content": "acute renal failure [SEP] Dynamic response of blood vessel in acute renal failure.", "tokenized_content": [2, 3939, 4604, 4574, 3, 5760, 2644, 1927, 2877, 8072, 1922, 3939, 4604, 4574, 18, 3]}, "items": [{"id": "p_5182", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5183", "content": "acute renal failure [SEP] In this study we postulated that during acute renal failure induced by gentamicin the transient or dynamic response of bloo", "tokenized_content": [2, 3939, 4604, 4574, 3, 1922, 2052, 2161, 2038, 14024, 1988, 2409, 3939, 4604, 4574, 2719, 2007, 17144, 1920, 6809, 2014, 5760, 2644, 1927, 16635, 1037, 3]}, "items": [{"id": "p_5183", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5184", "content": "gentamicin [SEP]  study we postulated that during acute renal failure induced by gentamicin the transient or dynamic response of blood vessels could be aff", "tokenized_content": [2, 17144, 3, 2161, 2038, 14024, 1988, 2409, 3939, 4604, 4574, 2719, 2007, 17144, 1920, 6809, 2014, 5760, 2644, 1927, 2877, 7208, 2578, 1998, 2633, 3]}, "items": [{"id": "p_5184", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_5185", "content": "vitamin C [SEP] essure in gentamicin-treated animals. The beneficial effects of vitamin C administration to gentamicin-treated animals are also confirmed", "tokenized_content": [2, 6111, 45, 3, 4023, 2027, 1922, 17144, 17, 2868, 3555, 18, 1920, 6928, 2564, 1927, 6111, 45, 4183, 1942, 17144, 17, 2868, 3555, 2032, 2222, 3982, 3]}, "items": [{"id": "p_5185", "content": "Ascorbic Acid [SEP] A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essent", "score": 1, "type": null, "tokenized_content": [2, 18265, 2687, 3, 43, 3798, 5056, 3547, 2712, 1942, 3817, 18, 2176, 1977, 2435, 10414, 1922, 24117, 12953, 1930, 3086, 14206, 18, 18265, 2687, 1977, 1925, 4023, 1939, 3]}]}
{"query": {"id": "q_5186", "content": "urea [SEP] reated animals are also confirmed through: lower level of blood urea and creatinine and higher level of potassium. The pressure dyna", "tokenized_content": [2, 10505, 3, 1964, 1981, 3555, 2032, 2222, 3982, 2596, 30, 2826, 2237, 1927, 2877, 10505, 1930, 9374, 1930, 2580, 2237, 1927, 9057, 18, 1920, 3772, 11165, 1019, 3]}, "items": [{"id": "p_5186", "content": "Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote", "score": 1, "type": null, "tokenized_content": [2, 10505, 3, 43, 3547, 5333, 1922, 1920, 3568, 2037, 14880, 4152, 2007, 1920, 30097, 8547, 1943, 1927, 3835, 4576, 18, 2176, 1977, 1920, 7944, 2482, 4863, 1927, 2174, 3]}]}
{"query": {"id": "q_5187", "content": "creatinine [SEP] imals are also confirmed through: lower level of blood urea and creatinine and higher level of potassium. The pressure dynamic responses o", "tokenized_content": [2, 9374, 3, 2042, 2472, 2032, 2222, 3982, 2596, 30, 2826, 2237, 1927, 2877, 10505, 1930, 9374, 1930, 2580, 2237, 1927, 9057, 18, 1920, 3772, 5760, 3387, 57, 3]}, "items": [{"id": "p_5187", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_5188", "content": "potassium [SEP] h: lower level of blood urea and creatinine and higher level of potassium. The pressure dynamic responses of isolated blood vessels show ", "tokenized_content": [2, 9057, 3, 50, 30, 2826, 2237, 1927, 2877, 10505, 1930, 9374, 1930, 2580, 2237, 1927, 9057, 18, 1920, 3772, 5760, 3387, 1927, 3937, 2877, 7208, 2146, 3]}, "items": [{"id": "p_5188", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_5189", "content": "Vitamin C [SEP] entamicin-treated animals (8.07 +/- 1.7 s vs. 5.64 +/- 0.18 s). Vitamin C administration induced slowdown of pressure change back to the ", "tokenized_content": [2, 6111, 45, 3, 8496, 16617, 17, 2868, 3555, 12, 28, 18, 6627, 15, 19, 17, 21, 18, 27, 61, 3201, 18, 25, 18, 4723, 15, 19, 17, 20, 18, 2654, 3]}, "items": [{"id": "p_5189", "content": "Ascorbic Acid [SEP] A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essent", "score": 1, "type": null, "tokenized_content": [2, 18265, 2687, 3, 43, 3798, 5056, 3547, 2712, 1942, 3817, 18, 2176, 1977, 2435, 10414, 1922, 24117, 12953, 1930, 3086, 14206, 18, 18265, 2687, 1977, 1925, 4023, 1939, 3]}]}
{"query": {"id": "q_5190", "content": "oxytocin [SEP] The hemodynamics of oxytocin and other vasoactive agents during neuraxial anesthesia for ces", "tokenized_content": [2, 17775, 3, 1920, 22482, 1927, 17775, 1930, 2303, 26613, 4820, 2409, 2974, 18049, 8871, 1958, 11641, 3]}, "items": [{"id": "p_5190", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_5191", "content": "Oxytocin [SEP] Oxytocin is a commonly used uterotonic that can cause significant and ev", "tokenized_content": [2, 17775, 3, 17775, 1977, 43, 5384, 2251, 19738, 24970, 1988, 2112, 3936, 2228, 1930, 2180, 3]}, "items": [{"id": "p_5191", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_5192", "content": "hypotension [SEP] monly used uterotonic that can cause significant and even fatal hypotension, particularly when given as a bolus. The resulting hypotension ", "tokenized_content": [2, 16453, 3, 2399, 1954, 2251, 19738, 24970, 1988, 2112, 3936, 2228, 1930, 3385, 11990, 16453, 16, 4443, 2469, 3258, 1966, 43, 14840, 18, 1920, 3864, 16453, 3]}, "items": [{"id": "p_5192", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_5193", "content": "stroke [SEP] this hypotension with a compensatory increase in heart rate and stroke volume. Oxytocin-induced hypotension at cesarean delivery may b", "tokenized_content": [2, 5235, 3, 2052, 16453, 1956, 43, 13447, 2760, 1922, 4003, 2769, 1930, 5235, 3776, 18, 17775, 17, 2719, 16453, 2019, 18334, 4868, 2278, 44, 3]}, "items": [{"id": "p_5193", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_5194", "content": "blood loss [SEP] potension at cesarean delivery may be incorrectly attributed to blood loss. Pulse power analysis (also called \"pulse contour analysis\") of", "tokenized_content": [2, 2877, 3257, 3, 2543, 3212, 2019, 18334, 4868, 2278, 1998, 25269, 6898, 1942, 2877, 3257, 18, 7110, 4215, 2333, 12, 2222, 6043, 6, 7110, 13998, 2333, 6, 13, 1927, 3]}, "items": [{"id": "p_5194", "content": "Postpartum Hemorrhage [SEP] Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than ", "score": 1, "type": null, "tokenized_content": [2, 13171, 10489, 3, 5799, 2877, 3257, 2037, 10885, 7633, 2458, 1956, 18902, 3876, 2014, 24445, 18, 2176, 1977, 3608, 1966, 2877, 3257, 3430, 2254, 3]}]}
{"query": {"id": "q_5195", "content": "Hypotension [SEP] ases of cesarean delivery performed under neuraxial anesthesia. Hypotension in response to oxytocin was associated with a decrease in syste", "tokenized_content": [2, 16453, 3, 28826, 1036, 1927, 18334, 4868, 2593, 2441, 2974, 18049, 8871, 18, 16453, 1922, 2644, 1942, 17775, 1982, 2458, 1956, 43, 3714, 1922, 8055, 1021, 3]}, "items": [{"id": "p_5195", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_5196", "content": "oxytocin [SEP] erformed under neuraxial anesthesia. Hypotension in response to oxytocin was associated with a decrease in systemic vascular resistance ", "tokenized_content": [2, 17775, 3, 2668, 16015, 2441, 2974, 18049, 8871, 18, 16453, 1922, 2644, 1942, 17775, 1982, 2458, 1956, 43, 3714, 1922, 5510, 4541, 3554, 3]}, "items": [{"id": "p_5196", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_5197", "content": "cyclophosphamide [SEP] n vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis.", "tokenized_content": [2, 17135, 3, 56, 26613, 6139, 13022, 7949, 12, 16107, 17, 19, 17, 13, 2518, 1956, 17135, 12, 6120, 13, 17, 2719, 9446, 3678, 18, 3]}, "items": [{"id": "p_5197", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_5198", "content": "CYP [SEP] tinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis.", "tokenized_content": [2, 6120, 3, 12347, 1923, 13022, 7949, 12, 16107, 17, 19, 17, 13, 2518, 1956, 17135, 12, 6120, 13, 17, 2719, 9446, 3678, 18, 3]}, "items": [{"id": "p_5198", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_5199", "content": "cystitis [SEP] tide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis.", "tokenized_content": [2, 9446, 3678, 3, 8685, 3695, 7949, 12, 16107, 17, 19, 17, 13, 2518, 1956, 17135, 12, 6120, 13, 17, 2719, 9446, 3678, 18, 3]}, "items": [{"id": "p_5199", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_5200", "content": "cyclophosphamide [SEP] tion and neurochemical properties in micturition pathways after cyclophosphamide (CYP)-induced cystitis. Given VIP's role as an anti-inflammator", "tokenized_content": [2, 17135, 3, 8685, 1916, 1930, 27297, 3879, 1922, 2206, 1031, 25682, 3873, 2256, 17135, 12, 6120, 13, 17, 2719, 9446, 3678, 18, 3258, 16107, 11, 61, 2770, 1966, 1925, 2246, 3]}, "items": [{"id": "p_5200", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_5201", "content": "CYP [SEP] ical properties in micturition pathways after cyclophosphamide (CYP)-induced cystitis. Given VIP's role as an anti-inflammatory med", "tokenized_content": [2, 6120, 3, 14784, 1024, 3879, 1922, 2206, 1031, 25682, 3873, 2256, 17135, 12, 6120, 13, 17, 2719, 9446, 3678, 18, 3258, 16107, 11, 61, 2770, 1966, 1925, 2246, 17, 3769, 3]}, "items": [{"id": "p_5201", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_5202", "content": "cystitis [SEP] es in micturition pathways after cyclophosphamide (CYP)-induced cystitis. Given VIP's role as an anti-inflammatory mediator, we hypothes", "tokenized_content": [2, 9446, 3678, 3, 2376, 1922, 2206, 1031, 25682, 3873, 2256, 17135, 12, 6120, 13, 17, 2719, 9446, 3678, 18, 3258, 16107, 11, 61, 2770, 1966, 1925, 2246, 17, 3769, 11370, 3]}, "items": [{"id": "p_5202", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_5203", "content": "bladder inflammation [SEP] o 5-fold increase). The data suggest that in VIP(-/-) mice with bladder inflammation, inflammatory mediators are increased above that observed in WT", "tokenized_content": [2, 7821, 4531, 3, 57, 25, 17, 3728, 2760, 13, 18, 1920, 2230, 3220, 1988, 1922, 16107, 12, 17, 19, 17, 13, 2518, 1956, 7821, 4531, 16, 3769, 9744, 2032, 2502, 3]}, "items": [{"id": "p_5203", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_5204", "content": "bladder dysfunction [SEP]  WT with CYP. This shift in balance may contribute to increased bladder dysfunction in VIP(-/-) mice with bladder inflammation and altered neuroche", "tokenized_content": [2, 7821, 5273, 3, 3751, 1956, 6120, 18, 2052, 5950, 1922, 6766, 2278, 4672, 1942, 2502, 7821, 5273, 1922, 16107, 12, 17, 19, 17, 13, 2518, 1956, 7821, 4531, 1930, 5520, 3]}, "items": [{"id": "p_5204", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_5205", "content": "uveitis [SEP] Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.", "tokenized_content": [2, 22140, 3, 17258, 3772, 1922, 2132, 1956, 22140, 2868, 1956, 26915, 3665, 13048, 4118, 27966, 11030, 18, 3]}, "items": [{"id": "p_5205", "content": "Uveitis [SEP] Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera", "score": 1, "type": null, "tokenized_content": [2, 22140, 3, 4531, 1927, 3131, 2014, 2136, 1927, 1920, 18217, 1019, 16, 1920, 5576, 12, 4541, 13, 29171, 1927, 1920, 5723, 16, 1930, 5384, 5884, 1920, 2303, 29171, 1036, 12, 8266, 1019, 3]}]}
{"query": {"id": "q_5206", "content": "fluocinolone acetonide [SEP] Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.", "tokenized_content": [2, 26915, 3665, 13048, 4118, 27966, 3, 17258, 3772, 1922, 2132, 1956, 22140, 2868, 1956, 26915, 3665, 13048, 4118, 27966, 11030, 18, 3]}, "items": [{"id": "p_5206", "content": "Fluocinolone Acetonide [SEP] A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, l", "score": 1, "type": null, "tokenized_content": [2, 26915, 3665, 13048, 4118, 27966, 3, 43, 14469, 10533, 2251, 12259, 1954, 1922, 1920, 2311, 1927, 3425, 4407, 4414, 18, 2176, 1977, 5394, 5789, 1966, 43, 22734, 16, 4669, 16, 54, 3]}]}
{"query": {"id": "q_5207", "content": "elevated intraocular pressure [SEP] OBJECTIVE: To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone ac", "tokenized_content": [2, 4664, 17258, 3772, 3, 4470, 30, 1942, 3809, 1920, 4332, 1930, 4280, 1927, 4664, 17258, 3772, 12, 12906, 13, 1922, 2132, 1956, 22140, 2868, 1956, 1920, 26915, 3665, 13048, 2000, 3]}, "items": [{"id": "p_5207", "content": "Ocular Hypertension [SEP] A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 5579, 3, 43, 2625, 1922, 2154, 1920, 17258, 3772, 1977, 4664, 3538, 2791, 1930, 2154, 2278, 2949, 1942, 12106, 18, 3]}]}
{"query": {"id": "q_5208", "content": "uveitis [SEP] agement of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal impla", "tokenized_content": [2, 22140, 3, 2632, 2017, 1927, 4664, 17258, 3772, 12, 12906, 13, 1922, 2132, 1956, 22140, 2868, 1956, 1920, 26915, 3665, 13048, 4118, 27966, 12, 5685, 13, 23580, 6313, 1019, 3]}, "items": [{"id": "p_5208", "content": "Uveitis [SEP] Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera", "score": 1, "type": null, "tokenized_content": [2, 22140, 3, 4531, 1927, 3131, 2014, 2136, 1927, 1920, 18217, 1019, 16, 1920, 5576, 12, 4541, 13, 29171, 1927, 1920, 5723, 16, 1930, 5384, 5884, 1920, 2303, 29171, 1036, 12, 8266, 1019, 3]}]}
{"query": {"id": "q_5209", "content": "fluocinolone acetonide [SEP] ocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. DESIGN: Pooled data from 3 multicent", "tokenized_content": [2, 26915, 3665, 13048, 4118, 27966, 3, 10046, 3772, 12, 12906, 13, 1922, 2132, 1956, 22140, 2868, 1956, 1920, 26915, 3665, 13048, 4118, 27966, 12, 5685, 13, 23580, 6237, 18, 3036, 3]}, "items": [{"id": "p_5209", "content": "Fluocinolone Acetonide [SEP] A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, l", "score": 1, "type": null, "tokenized_content": [2, 26915, 3665, 13048, 4118, 27966, 3, 43, 14469, 10533, 2251, 12259, 1954, 1922, 1920, 2311, 1927, 3425, 4407, 4414, 18, 2176, 1977, 5394, 5789, 1966, 43, 22734, 16, 4669, 16, 54, 3]}]}
{"query": {"id": "q_5210", "content": "FA [SEP]  patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. DESIGN: Pooled data from 3 multicenter, ", "tokenized_content": [2, 5685, 3, 2132, 1956, 22140, 2868, 1956, 1920, 26915, 3665, 13048, 4118, 27966, 12, 5685, 13, 23580, 6237, 18, 3036, 30, 7803, 2230, 2037, 23, 14620, 16, 3]}, "items": [{"id": "p_5210", "content": "Fluocinolone Acetonide [SEP] A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, l", "score": 1, "type": null, "tokenized_content": [2, 26915, 3665, 13048, 4118, 27966, 3, 43, 14469, 10533, 2251, 12259, 1954, 1922, 1920, 2311, 1927, 3425, 4407, 4414, 18, 2176, 1977, 5394, 5789, 1966, 43, 22734, 16, 4669, 16, 54, 3]}]}
{"query": {"id": "q_5211", "content": "hypotony [SEP] OP-lowering medication) in 85.1% of eyes at 1 year. The rate of hypotony (IOP </= 5 mm Hg) following IOP-lowering surgery (42.5%) was no", "tokenized_content": [2, 12201, 14186, 3, 2494, 17, 11187, 6093, 13, 1922, 5140, 18, 21, 9, 1927, 7127, 2019, 21, 2476, 18, 1920, 2769, 1927, 12201, 14186, 12, 12906, 32, 19, 33, 25, 3]}, "items": [{"id": "p_5211", "content": "Ocular Hypotension [SEP] Abnormally low intraocular pressure often related to chronic inflammation (uveitis).\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 16453, 3, 20756, 2330, 17258, 3772, 3868, 2712, 1942, 3724, 4531, 12, 22140, 13, 18, 3]}]}
{"query": {"id": "q_5212", "content": "Parkinson's disease [SEP] A resurgence of interest in the surgical treatment of Parkinson's disease (PD) came with the rediscovery of posteroventral pallidotomy by", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 43, 1995, 28562, 15895, 1021, 1927, 4501, 1922, 1920, 4548, 2311, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 12411, 1956, 1920, 2312, 16409, 2004, 3]}, "items": [{"id": "p_5212", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_5213", "content": "PD [SEP] e of interest in the surgical treatment of Parkinson's disease (PD) came with the rediscovery of posteroventral pallidotomy by Lai", "tokenized_content": [2, 3203, 3, 47, 1927, 4501, 1922, 1920, 4548, 2311, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 12411, 1956, 1920, 2312, 16409, 2004, 1012, 1927, 21270, 24439, 9588, 12574, 22389, 3]}, "items": [{"id": "p_5213", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_5214", "content": "dyskinesias [SEP] iterature pallidotomy improves the \"on\" symptoms of PD, such as dyskinesias, as well as the \"off\" symptoms, such as rigidity, bradykinesia,", "tokenized_content": [2, 3890, 26682, 1036, 3, 9642, 2541, 12574, 22389, 4575, 14930, 10204, 1920, 6, 1990, 6, 3601, 1927, 3203, 16, 2427, 1966, 3890, 26682, 1036, 16, 1966, 2486, 1966, 1920, 6, 3]}, "items": [{"id": "p_5214", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5215", "content": "rigidity [SEP] PD, such as dyskinesias, as well as the \"off\" symptoms, such as rigidity, bradykinesia, and on-off fluctuations. Pallidal stimulation im", "tokenized_content": [2, 20471, 3, 3203, 16, 2427, 1966, 3890, 26682, 1036, 16, 1966, 2486, 1966, 1920, 6, 4013, 6, 3601, 16, 2427, 1966, 20471, 16, 20152, 26682, 16, 1930, 1990, 17, 4013, 3]}, "items": [{"id": "p_5215", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_5216", "content": "bradykinesia [SEP] s dyskinesias, as well as the \"off\" symptoms, such as rigidity, bradykinesia, and on-off fluctuations. Pallidal stimulation improves bradyki", "tokenized_content": [2, 20152, 26682, 3, 61, 3890, 26682, 1036, 16, 1966, 2486, 1966, 1920, 6, 4013, 6, 3601, 16, 2427, 1966, 20471, 16, 20152, 26682, 16, 1930, 1990, 17, 4013, 11429, 18, 3]}, "items": [{"id": "p_5216", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_5217", "content": "levodopa [SEP]  a minor extent; however, its strength seems to be in improving levodopa-induced dyskinesias. Stimulation often produces an improvement ", "tokenized_content": [2, 26723, 3, 43, 5857, 5064, 31, 2406, 16, 2496, 4568, 6123, 1942, 1998, 1922, 7440, 26723, 17, 2719, 3890, 26682, 1036, 18, 4177, 3868, 9300, 1925, 4990, 3]}, "items": [{"id": "p_5217", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_5218", "content": "Dexatrim [SEP] Case report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction.", "tokenized_content": [2, 7473, 12078, 1980, 3, 3087, 3809, 30, 7473, 12078, 1980, 12, 7971, 20194, 4296, 3812, 13, 1966, 43, 3936, 1927, 6497, 8358, 18, 3]}, "items": [{"id": "p_5218", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_5219", "content": "Phenylpropanolamine [SEP] Case report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction.", "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 3087, 3809, 30, 7473, 12078, 1980, 12, 7971, 20194, 4296, 3812, 13, 1966, 43, 3936, 1927, 6497, 8358, 18, 3]}, "items": [{"id": "p_5219", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_5220", "content": "myocardial infarction [SEP] Case report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction.", "tokenized_content": [2, 6497, 8358, 3, 3087, 3809, 30, 7473, 12078, 1980, 12, 7971, 20194, 4296, 3812, 13, 1966, 43, 3936, 1927, 6497, 8358, 18, 3]}, "items": [{"id": "p_5220", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_5221", "content": "Phenylpropanolamine [SEP] Phenylpropanolamine (PPA) is a sympathetic amine used in over-the-counter cold reme", "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 1977, 43, 11739, 13610, 2251, 1922, 2338, 17, 1920, 17, 5836, 6685, 2500, 1021, 3]}, "items": [{"id": "p_5221", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_5222", "content": "PPA [SEP] Phenylpropanolamine (PPA) is a sympathetic amine used in over-the-counter cold remedies ", "tokenized_content": [2, 27301, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 1977, 43, 11739, 13610, 2251, 1922, 2338, 17, 1920, 17, 5836, 6685, 17186, 2062, 3]}, "items": [{"id": "p_5222", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_5223", "content": "amine [SEP] Phenylpropanolamine (PPA) is a sympathetic amine used in over-the-counter cold reme", "tokenized_content": [2, 13610, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 1977, 43, 11739, 13610, 2251, 1922, 2338, 17, 1920, 17, 5836, 6685, 2500, 1021, 3]}, "items": [{"id": "p_5223", "content": "Amines [SEP] A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dic", "score": 1, "type": null, "tokenized_content": [2, 20739, 3, 43, 2210, 1927, 4300, 3595, 2037, 14880, 2007, 26276, 6805, 12467, 1958, 1920, 6201, 1036, 18, 12, 2037, 6216, 10, 2118, 12940, 1023, 11, 61, 4399, 9192, 3]}]}
{"query": {"id": "q_5224", "content": "hypertensive [SEP] ontrol preparations worldwide. Its use has been associated with hypertensive episodes and hemorrhagic strokes in younger women. Several repo", "tokenized_content": [2, 11706, 3, 9056, 2226, 9815, 8563, 18, 2496, 2485, 2258, 2252, 2458, 1956, 11706, 9232, 1930, 16052, 21655, 1922, 7237, 3089, 18, 2980, 3073, 1037, 3]}, "items": [{"id": "p_5224", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5225", "content": "hemorrhagic [SEP] ide. Its use has been associated with hypertensive episodes and hemorrhagic strokes in younger women. Several reports have linked the abuse", "tokenized_content": [2, 16052, 3, 9043, 18, 2496, 2485, 2258, 2252, 2458, 1956, 11706, 9232, 1930, 16052, 21655, 1922, 7237, 3089, 18, 2980, 4710, 2162, 4624, 1920, 7764, 3]}, "items": [{"id": "p_5225", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_5226", "content": "strokes [SEP]  has been associated with hypertensive episodes and hemorrhagic strokes in younger women. Several reports have linked the abuse of PPA ", "tokenized_content": [2, 21655, 3, 2258, 2252, 2458, 1956, 11706, 9232, 1930, 16052, 21655, 1922, 7237, 3089, 18, 2980, 4710, 2162, 4624, 1920, 7764, 1927, 27301, 3]}, "items": [{"id": "p_5226", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_5227", "content": "myocardial injury [SEP] ounger women. Several reports have linked the abuse of PPA with myocardial injury, especially when overdose is involved. We report here the first", "tokenized_content": [2, 6497, 4047, 3, 17208, 2029, 1915, 3089, 18, 2980, 4710, 2162, 4624, 1920, 7764, 1927, 27301, 1956, 6497, 4047, 16, 4369, 2469, 21090, 1977, 3286, 18, 2038, 3809, 3410, 1920, 3]}, "items": [{"id": "p_5227", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_5228", "content": "overdose [SEP] linked the abuse of PPA with myocardial injury, especially when overdose is involved. We report here the first case of Dexatrim (PPA)-in", "tokenized_content": [2, 21090, 3, 4624, 1920, 7764, 1927, 27301, 1956, 6497, 4047, 16, 4369, 2469, 21090, 1977, 3286, 18, 2038, 3809, 3410, 1920, 2561, 3087, 1927, 7473, 12078, 1980, 12, 27301, 13, 3]}, "items": [{"id": "p_5228", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_5229", "content": "Dexatrim [SEP] lly when overdose is involved. We report here the first case of Dexatrim (PPA)-induced myocardial injury in a young woman who was using ", "tokenized_content": [2, 7473, 12078, 1980, 3, 10748, 1012, 2469, 21090, 1977, 3286, 18, 2038, 3809, 3410, 1920, 2561, 3087, 1927, 7473, 12078, 1980, 12, 27301, 13, 17, 2719, 6497, 4047, 1922, 43, 3]}, "items": [{"id": "p_5229", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_5230", "content": "Risperidone [SEP] Risperidone-associated, benign transient visual disturbances in schizophren", "tokenized_content": [2, 26991, 3, 26991, 17, 2458, 16, 8867, 6809, 3737, 12654, 1922, 7603, 3]}, "items": [{"id": "p_5230", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_5231", "content": "visual disturbances [SEP] Risperidone-associated, benign transient visual disturbances in schizophrenic patients with a past history of LSD abuse.", "tokenized_content": [2, 3737, 12654, 3, 26991, 17, 2458, 16, 8867, 6809, 3737, 12654, 1922, 28247, 2132, 1956, 43, 5375, 4403, 1927, 23401, 7764, 18, 3]}, "items": [{"id": "p_5231", "content": "Perceptual Disorders [SEP] Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense ", "score": 1, "type": null, "tokenized_content": [2, 12365, 4414, 3, 4328, 4414, 4378, 2007, 1925, 5761, 3682, 1942, 18016, 1920, 4899, 1927, 9423, 2014, 10928, 2596, 2485, 1927, 1920, 7534, 3]}]}
{"query": {"id": "q_5232", "content": "schizophrenic [SEP] Risperidone-associated, benign transient visual disturbances in schizophrenic patients with a past history of LSD abuse.", "tokenized_content": [2, 28247, 3, 26991, 17, 2458, 16, 8867, 6809, 3737, 12654, 1922, 28247, 2132, 1956, 43, 5375, 4403, 1927, 23401, 7764, 18, 3]}, "items": [{"id": "p_5232", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_5233", "content": "LSD [SEP] l disturbances in schizophrenic patients with a past history of LSD abuse.", "tokenized_content": [2, 23401, 3, 54, 12654, 1922, 28247, 2132, 1956, 43, 5375, 4403, 1927, 23401, 7764, 18, 3]}, "items": [{"id": "p_5233", "content": "Lysergic Acid Diethylamide [SEP] Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at s", "score": 1, "type": null, "tokenized_content": [2, 3629, 5237, 2687, 18622, 5482, 3, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 11949, 1991, 12, 19887, 2927, 2523, 25945, 16648, 13, 18, 2176, 2258, 2796, 2564, 1990, 21292, 3771, 2710, 18394, 2019, 61, 3]}]}
{"query": {"id": "q_5234", "content": "schizophrenic [SEP] Two schizophrenic patients, who had a prior history of LSD abuse and who had prev", "tokenized_content": [2, 28247, 3, 2288, 28247, 2132, 16, 2746, 2430, 43, 3432, 4403, 1927, 23401, 7764, 1930, 2746, 2430, 2817, 3]}, "items": [{"id": "p_5234", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_5235", "content": "LSD [SEP] Two schizophrenic patients, who had a prior history of LSD abuse and who had previously developed EPS with classic antipsy", "tokenized_content": [2, 23401, 3, 2288, 28247, 2132, 16, 2746, 2430, 43, 3432, 4403, 1927, 23401, 7764, 1930, 2746, 2430, 3024, 3530, 9178, 1956, 12211, 2246, 9196, 3]}, "items": [{"id": "p_5235", "content": "Lysergic Acid Diethylamide [SEP] Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at s", "score": 1, "type": null, "tokenized_content": [2, 3629, 5237, 2687, 18622, 5482, 3, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 11949, 1991, 12, 19887, 2927, 2523, 25945, 16648, 13, 18, 2176, 2258, 2796, 2564, 1990, 21292, 3771, 2710, 18394, 2019, 61, 3]}]}
{"query": {"id": "q_5236", "content": "EPS [SEP] d a prior history of LSD abuse and who had previously developed EPS with classic antipsychotics, were successfully treated with ris", "tokenized_content": [2, 9178, 3, 46, 43, 3432, 4403, 1927, 23401, 7764, 1930, 2746, 2430, 3024, 3530, 9178, 1956, 12211, 21474, 16, 1985, 6664, 2868, 1956, 2511, 3]}, "items": [{"id": "p_5236", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_5237", "content": "risperidone [SEP] EPS with classic antipsychotics, were successfully treated with risperidone. They both reported short episodes of transient visual disturba", "tokenized_content": [2, 26991, 3, 9178, 1956, 12211, 21474, 16, 1985, 6664, 2868, 1956, 26991, 18, 2611, 2321, 2568, 3662, 9232, 1927, 6809, 3737, 7863, 1019, 3]}, "items": [{"id": "p_5237", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_5238", "content": "visual disturbances [SEP] ith risperidone. They both reported short episodes of transient visual disturbances, which appeared immediately after starting treatment with rispe", "tokenized_content": [2, 3737, 12654, 3, 24737, 26991, 18, 2611, 2321, 2568, 3662, 9232, 1927, 6809, 3737, 12654, 16, 2154, 6209, 6183, 2256, 6801, 2311, 1956, 2511, 9626, 3]}, "items": [{"id": "p_5238", "content": "Perceptual Disorders [SEP] Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense ", "score": 1, "type": null, "tokenized_content": [2, 12365, 4414, 3, 4328, 4414, 4378, 2007, 1925, 5761, 3682, 1942, 18016, 1920, 4899, 1927, 9423, 2014, 10928, 2596, 2485, 1927, 1920, 7534, 3]}]}
{"query": {"id": "q_5239", "content": "Risperidone [SEP] y experienced as \"flashbacks\" related to prior LSD consumption. Risperidone administration was continued and the visual disturbances gradua", "tokenized_content": [2, 26991, 3, 67, 6090, 1966, 6, 13207, 5753, 1036, 6, 2712, 1942, 3432, 23401, 5434, 18, 26991, 4183, 1982, 7583, 1930, 1920, 3737, 12654, 5274, 12169, 3]}, "items": [{"id": "p_5239", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_5240", "content": "poly(ADP-ribose) [SEP] Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced he", "tokenized_content": [2, 4286, 12, 9828, 17, 17870, 13, 3, 2936, 1927, 4286, 12, 9828, 17, 17870, 13, 6479, 7624, 1942, 2740, 1927, 12377, 17, 2719, 2234, 3]}, "items": [{"id": "p_5240", "content": "Poly Adenosine Diphosphate Ribose [SEP] A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.\n ", "score": 1, "type": null, "tokenized_content": [2, 4286, 10125, 23266, 17870, 3, 43, 15176, 15274, 5333, 2037, 1920, 9828, 17, 17870, 11804, 1927, 21393, 17, 15643, 21302, 12, 6577, 13, 2007, 4286, 12, 9828, 17, 17870, 13, 20910, 18, 3]}]}
{"query": {"id": "q_5241", "content": "doxorubicin [SEP] on of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.", "tokenized_content": [2, 12377, 3, 1990, 1927, 4286, 12, 9828, 17, 17870, 13, 6479, 7624, 1942, 2740, 1927, 12377, 17, 2719, 4003, 4574, 18, 3]}, "items": [{"id": "p_5241", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_5242", "content": "heart failure [SEP] e) polymerase contributes to development of doxorubicin-induced heart failure.", "tokenized_content": [2, 4003, 4574, 3, 47, 13, 6479, 7624, 1942, 2740, 1927, 12377, 17, 2719, 4003, 4574, 18, 3]}, "items": [{"id": "p_5242", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_5243", "content": "poly(ADP-ribose) [SEP] Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) by oxidant-mediated DNA damage is an importan", "tokenized_content": [2, 4286, 12, 9828, 17, 17870, 13, 3, 2936, 1927, 1920, 4254, 4113, 4286, 12, 9828, 17, 17870, 13, 6479, 12, 12007, 13, 2007, 16138, 17, 3434, 2678, 4293, 1977, 1925, 3]}, "items": [{"id": "p_5243", "content": "Poly Adenosine Diphosphate Ribose [SEP] A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.\n ", "score": 1, "type": null, "tokenized_content": [2, 4286, 10125, 23266, 17870, 3, 43, 15176, 15274, 5333, 2037, 1920, 9828, 17, 17870, 11804, 1927, 21393, 17, 15643, 21302, 12, 6577, 13, 2007, 4286, 12, 9828, 17, 17870, 13, 20910, 18, 3]}]}
{"query": {"id": "q_5244", "content": "cardiotoxicity [SEP]  Increased oxidative stress is a major factor implicated in the cardiotoxicity of doxorubicin (DOX), a widely used antitumor anthracycline ant", "tokenized_content": [2, 30490, 3, 2502, 5163, 3071, 1977, 43, 3044, 2991, 6835, 1922, 1920, 30490, 1927, 12377, 12, 7169, 13, 16, 43, 5673, 2251, 11775, 30021, 4942, 3]}, "items": [{"id": "p_5244", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_5245", "content": "doxorubicin [SEP] ve stress is a major factor implicated in the cardiotoxicity of doxorubicin (DOX), a widely used antitumor anthracycline antibiotic. Thus, ", "tokenized_content": [2, 12377, 3, 3428, 3071, 1977, 43, 3044, 2991, 6835, 1922, 1920, 30490, 1927, 12377, 12, 7169, 13, 16, 43, 5673, 2251, 11775, 30021, 7267, 18, 2842, 16, 3]}, "items": [{"id": "p_5245", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_5246", "content": "DOX [SEP] a major factor implicated in the cardiotoxicity of doxorubicin (DOX), a widely used antitumor anthracycline antibiotic. Thus, we hy", "tokenized_content": [2, 7169, 3, 43, 3044, 2991, 6835, 1922, 1920, 30490, 1927, 12377, 12, 7169, 13, 16, 43, 5673, 2251, 11775, 30021, 7267, 18, 2842, 16, 2038, 4527, 3]}, "items": [{"id": "p_5246", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_5247", "content": "anthracycline [SEP] he cardiotoxicity of doxorubicin (DOX), a widely used antitumor anthracycline antibiotic. Thus, we hypothesized that the activation of PARP m", "tokenized_content": [2, 30021, 3, 2234, 30490, 1927, 12377, 12, 7169, 13, 16, 43, 5673, 2251, 11775, 30021, 7267, 18, 2842, 16, 2038, 7149, 1988, 1920, 2936, 1927, 12007, 55, 3]}, "items": [{"id": "p_5247", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_5248", "content": "PJ34 [SEP] macological inhibition with the phenanthridinone PARP inhibitor PJ34, we now demonstrate the role of PARP in the development of card", "tokenized_content": [2, 16978, 4857, 3, 3433, 2477, 3523, 1956, 1920, 30231, 20332, 22123, 12007, 4106, 16978, 4857, 16, 2038, 5195, 4504, 1920, 2770, 1927, 12007, 1922, 1920, 2740, 1927, 9429, 3]}, "items": [{"id": "p_5248", "content": "N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 12, 18588, 17, 25, 16, 26, 17, 11842, 17616, 7744, 20332, 1921, 17, 22, 17, 12111, 13, 17, 56, 16, 56, 17, 9780, 27457, 16675, 3, 3]}]}
{"query": {"id": "q_5249", "content": "cardiac dysfunction [SEP] PJ34, we now demonstrate the role of PARP in the development of cardiac dysfunction induced by DOX. PARP-1+/+ and PARP-1-/- mice received a single ", "tokenized_content": [2, 4435, 5273, 3, 16978, 4857, 16, 2038, 5195, 4504, 1920, 2770, 1927, 12007, 1922, 1920, 2740, 1927, 4435, 5273, 2719, 2007, 7169, 18, 12007, 17, 21, 15, 19, 15, 1930, 3]}, "items": [{"id": "p_5249", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_5250", "content": "lactate [SEP] J34 significantly reduced the DOX-induced increase in the serum lactate dehydrogenase and creatine kinase activities but not metallopro", "tokenized_content": [2, 9456, 3, 52, 4857, 2567, 3028, 1920, 7169, 17, 2719, 2760, 1922, 1920, 3256, 9456, 9294, 1930, 17784, 4016, 4209, 2308, 2084, 8969, 12964, 3]}, "items": [{"id": "p_5250", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_5251", "content": "creatine [SEP] the DOX-induced increase in the serum lactate dehydrogenase and creatine kinase activities but not metalloproteinase activation in the h", "tokenized_content": [2, 17784, 3, 1920, 7169, 17, 2719, 2760, 1922, 1920, 3256, 9456, 9294, 1930, 17784, 4016, 4209, 2308, 2084, 18895, 2936, 1922, 1920, 50, 3]}, "items": [{"id": "p_5251", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_5252", "content": "cardiac complications [SEP]  may exert protective effects against the development of severe cardiac complications associated with the DOX treatment.", "tokenized_content": [2, 4435, 5021, 3, 2278, 10788, 6337, 2564, 3316, 1920, 2740, 1927, 4010, 4435, 5021, 2458, 1956, 1920, 7169, 2311, 18, 3]}, "items": [{"id": "p_5252", "content": "Cardiac Complexes, Premature [SEP] A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atr", "score": 1, "type": null, "tokenized_content": [2, 4435, 5048, 16, 9839, 3, 43, 2210, 1927, 4435, 16934, 1922, 2154, 1920, 4435, 15465, 2032, 2084, 7796, 2019, 1920, 3132, 6952, 17075, 6267, 18, 2611, 3951, 2321, 6204, 3]}]}
{"query": {"id": "q_5253", "content": "Fluconazole [SEP] Fluconazole-induced torsade de pointes.", "tokenized_content": [2, 24585, 3, 24585, 17, 2719, 14823, 2873, 2028, 3575, 1918, 18, 3]}, "items": [{"id": "p_5253", "content": "Fluconazole [SEP] Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24585, 3, 5083, 6984, 15216, 5899, 1988, 1977, 2251, 1942, 2297, 26302, 29469, 1930, 11829, 11748, 16780, 1922, 8494, 18, 3]}]}
{"query": {"id": "q_5254", "content": "torsade de pointes [SEP] Fluconazole-induced torsade de pointes.", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 24585, 17, 2719, 14823, 2873, 2028, 3575, 1918, 18, 3]}, "items": [{"id": "p_5254", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_5255", "content": "fluconazole [SEP] OBJECTIVE: To present a case of fluconazole-associated torsade de pointes (TDP) and discuss fluconazole's r", "tokenized_content": [2, 24585, 3, 4470, 30, 1942, 2481, 43, 3087, 1927, 24585, 17, 2458, 14823, 2873, 2028, 3575, 1918, 12, 15390, 13, 1930, 3891, 24585, 11, 61, 60, 3]}, "items": [{"id": "p_5255", "content": "Fluconazole [SEP] Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24585, 3, 5083, 6984, 15216, 5899, 1988, 1977, 2251, 1942, 2297, 26302, 29469, 1930, 11829, 11748, 16780, 1922, 8494, 18, 3]}]}
{"query": {"id": "q_5256", "content": "torsade de pointes [SEP] OBJECTIVE: To present a case of fluconazole-associated torsade de pointes (TDP) and discuss fluconazole's role in causing TDP. CASE SUMMA", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 4470, 30, 1942, 2481, 43, 3087, 1927, 24585, 17, 2458, 14823, 2873, 2028, 3575, 1918, 12, 15390, 13, 1930, 3891, 24585, 11, 61, 2770, 3]}, "items": [{"id": "p_5256", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_5257", "content": "TDP [SEP] To present a case of fluconazole-associated torsade de pointes (TDP) and discuss fluconazole's role in causing TDP. CASE SUMMARY: A", "tokenized_content": [2, 15390, 3, 1942, 2481, 43, 3087, 1927, 24585, 17, 2458, 14823, 2873, 2028, 3575, 1918, 12, 15390, 13, 1930, 3891, 24585, 11, 61, 2770, 1922, 7538, 15390, 18, 3087, 6099, 3]}, "items": [{"id": "p_5257", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_5258", "content": "coronary artery disease [SEP] nazole The patient had no other risk factors for TDP, including coronary artery disease, cardiomyopathy, congestive heart failure, and electrolyte abno", "tokenized_content": [2, 5846, 5511, 2573, 3, 4049, 13642, 1952, 1920, 2774, 2430, 2239, 2303, 2565, 2790, 1958, 15390, 16, 2710, 5846, 5511, 2573, 16, 14141, 16, 20180, 4003, 4574, 16, 1930, 15428, 3]}, "items": [{"id": "p_5258", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_5259", "content": "cardiomyopathy [SEP]  other risk factors for TDP, including coronary artery disease, cardiomyopathy, congestive heart failure, and electrolyte abnormalities There ", "tokenized_content": [2, 14141, 3, 2303, 2565, 2790, 1958, 15390, 16, 2710, 5846, 5511, 2573, 16, 14141, 16, 20180, 4003, 4574, 16, 1930, 15428, 6754, 2276, 3]}, "items": [{"id": "p_5259", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_5260", "content": "congestive heart failure [SEP] ors for TDP, including coronary artery disease, cardiomyopathy, congestive heart failure, and electrolyte abnormalities There was a temporal association", "tokenized_content": [2, 20180, 4003, 4574, 3, 14957, 1958, 15390, 16, 2710, 5846, 5511, 2573, 16, 14141, 16, 20180, 4003, 4574, 16, 1930, 15428, 6754, 2276, 1982, 43, 5338, 3279, 3]}, "items": [{"id": "p_5260", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_5261", "content": "premature ventricular contractions [SEP] nazole was discontinued; however, the patient continued to have premature ventricular contractions and nonsustained ventricular tachycardia (NSVT) until six days ", "tokenized_content": [2, 9839, 6493, 15465, 3, 4049, 13642, 1952, 1982, 16087, 31, 2406, 16, 1920, 2774, 7583, 1942, 2162, 9839, 6493, 15465, 1930, 6771, 2892, 2368, 6493, 17397, 12, 4246, 25641, 13, 3]}, "items": [{"id": "p_5261", "content": "Ventricular Premature Complexes [SEP] A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS compl", "score": 1, "type": null, "tokenized_content": [2, 6493, 9839, 5048, 3, 43, 2601, 1927, 4435, 18346, 1956, 9839, 15465, 1927, 1920, 4003, 21008, 18, 2176, 1977, 4378, 2007, 1920, 9839, 22355, 6581, 3]}]}
{"query": {"id": "q_5262", "content": "ventricular tachycardia [SEP] ued to have premature ventricular contractions and nonsustained ventricular tachycardia (NSVT) until six days after drug cessation DISCUSSION: Use of t", "tokenized_content": [2, 6493, 17397, 3, 63, 1919, 1942, 2162, 9839, 6493, 15465, 1930, 6771, 2892, 2368, 6493, 17397, 12, 4246, 25641, 13, 4801, 3798, 3000, 2256, 2838, 10975, 7248, 30, 2485, 1927, 3]}, "items": [{"id": "p_5262", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_5263", "content": "NSVT [SEP] tricular contractions and nonsustained ventricular tachycardia (NSVT) until six days after drug cessation DISCUSSION: Use of the Nar", "tokenized_content": [2, 4246, 25641, 3, 12258, 2168, 15465, 1930, 6771, 2892, 2368, 6493, 17397, 12, 4246, 25641, 13, 4801, 3798, 3000, 2256, 2838, 10975, 7248, 30, 2485, 1927, 1920, 7612, 3]}, "items": [{"id": "p_5263", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_5264", "content": "depression [SEP] uconazole and the development of TDP. The possible mechanism is depression of rapidly activating delayed rectifier potassium currents. In ", "tokenized_content": [2, 4621, 3, 8577, 17016, 1930, 1920, 2740, 1927, 15390, 18, 1920, 3216, 2856, 1977, 4621, 1927, 6221, 8019, 7083, 26090, 3453, 9057, 9058, 18, 1922, 3]}, "items": [{"id": "p_5264", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_5265", "content": "potassium [SEP] mechanism is depression of rapidly activating delayed rectifier potassium currents. In our patient, there was no other etiology identifie", "tokenized_content": [2, 9057, 3, 2856, 1977, 4621, 1927, 6221, 8019, 7083, 26090, 3453, 9057, 9058, 18, 1922, 2342, 2774, 16, 2276, 1982, 2239, 2303, 10383, 2473, 2621, 3]}, "items": [{"id": "p_5265", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_5266", "content": "QT prolongation [SEP] ient, there was no other etiology identified that could explain QT prolongation or TDP The complete disappearance of NSVT and premature ventric", "tokenized_content": [2, 8877, 20334, 3, 10116, 4905, 16, 2276, 1982, 2239, 2303, 10383, 2899, 1988, 2578, 5895, 8877, 20334, 2014, 15390, 1920, 4080, 18271, 1927, 4246, 25641, 1930, 9839, 4699, 1935, 3]}, "items": [{"id": "p_5266", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_5267", "content": "prolongation of the QT interval [SEP]  should be aware that fluconazole, even at low doses, may cause prolongation of the QT interval, leading to TDP. Serial electrocardiographic monitoring may be ", "tokenized_content": [2, 20334, 1927, 1920, 8877, 4979, 3, 3066, 1998, 11207, 1988, 24585, 16, 3385, 2019, 2330, 5312, 16, 2278, 3936, 20334, 1927, 1920, 8877, 4979, 16, 4523, 1942, 15390, 18, 9285, 3]}, "items": [{"id": "p_5267", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_5268", "content": "ventricular arrhythmias [SEP] hen fluconazole is administered in patients who are at risk for ventricular arrhythmias.", "tokenized_content": [2, 6493, 16934, 3, 14618, 24585, 1977, 5254, 1922, 2132, 2746, 2032, 2019, 2565, 1958, 6493, 16934, 18, 3]}, "items": [{"id": "p_5268", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_5269", "content": "methylprednisolone [SEP] High-dose methylprednisolone may do more harm for spinal cord injury.", "tokenized_content": [2, 30087, 3, 2149, 17, 3253, 30087, 2278, 2608, 2253, 7613, 1958, 6071, 6670, 4047, 18, 3]}, "items": [{"id": "p_5269", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_5270", "content": "spinal cord injury [SEP] High-dose methylprednisolone may do more harm for spinal cord injury.", "tokenized_content": [2, 6071, 6670, 4047, 3, 2149, 17, 3253, 30087, 2278, 2608, 2253, 7613, 1958, 6071, 6670, 4047, 18, 3]}, "items": [{"id": "p_5270", "content": "Spinal Cord Injuries [SEP] Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHI", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 8209, 3, 19879, 1930, 2447, 17, 19879, 8209, 1942, 1920, 6071, 6670, 3864, 2037, 10242, 5771, 9146, 12, 47, 18, 49, 18, 16, 14107, 16, 20992, 6150, 1991, 31, 2003, 1033, 3]}]}
{"query": {"id": "q_5271", "content": "Spinal Cord Injury [SEP] Because of the National Acute Spinal Cord Injury Studies (NASCIS), high-dose methylprednisolone became the stand", "tokenized_content": [2, 6071, 6670, 4047, 3, 2882, 1927, 1920, 3852, 3939, 6071, 6670, 4047, 2351, 12, 16062, 1937, 13, 16, 2149, 17, 3253, 30087, 7935, 1920, 2924, 3]}, "items": [{"id": "p_5271", "content": "Spinal Cord Injuries [SEP] Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHI", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 8209, 3, 19879, 1930, 2447, 17, 19879, 8209, 1942, 1920, 6071, 6670, 3864, 2037, 10242, 5771, 9146, 12, 47, 18, 49, 18, 16, 14107, 16, 20992, 6150, 1991, 31, 2003, 1033, 3]}]}
{"query": {"id": "q_5272", "content": "methylprednisolone [SEP] e National Acute Spinal Cord Injury Studies (NASCIS), high-dose methylprednisolone became the standard of care for the acute spinal cord injury. I", "tokenized_content": [2, 30087, 3, 47, 3852, 3939, 6071, 6670, 4047, 2351, 12, 16062, 1937, 13, 16, 2149, 17, 3253, 30087, 7935, 1920, 2970, 1927, 2859, 1958, 1920, 3939, 6071, 6670, 4047, 18, 3]}, "items": [{"id": "p_5272", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_5273", "content": "spinal cord injury [SEP] se methylprednisolone became the standard of care for the acute spinal cord injury. In the NASCIS, there was no mention regarding the possibility ", "tokenized_content": [2, 6071, 6670, 4047, 3, 2058, 30087, 7935, 1920, 2970, 1927, 2859, 1958, 1920, 3939, 6071, 6670, 4047, 18, 1922, 1920, 16062, 1937, 16, 2276, 1982, 2239, 14515, 4667, 1920, 5341, 3]}, "items": [{"id": "p_5273", "content": "Spinal Cord Injuries [SEP] Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHI", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 8209, 3, 19879, 1930, 2447, 17, 19879, 8209, 1942, 1920, 6071, 6670, 3864, 2037, 10242, 5771, 9146, 12, 47, 18, 49, 18, 16, 14107, 16, 20992, 6150, 1991, 31, 2003, 1033, 3]}]}
{"query": {"id": "q_5274", "content": "corticosteroid [SEP] NASCIS, there was no mention regarding the possibility of acute corticosteroid myopathy that high-dose methylprednisolone may cause. The dosag", "tokenized_content": [2, 17980, 3, 16062, 1937, 16, 2276, 1982, 2239, 14515, 4667, 1920, 5341, 1927, 3939, 17980, 25017, 1988, 2149, 17, 3253, 30087, 2278, 3936, 18, 1920, 4220, 2006, 3]}, "items": [{"id": "p_5274", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_5275", "content": "myopathy [SEP] as no mention regarding the possibility of acute corticosteroid myopathy that high-dose methylprednisolone may cause. The dosage of meth", "tokenized_content": [2, 25017, 3, 1966, 2239, 14515, 4667, 1920, 5341, 1927, 3939, 17980, 25017, 1988, 2149, 17, 3253, 30087, 2278, 3936, 18, 1920, 9998, 1927, 2295, 3]}, "items": [{"id": "p_5275", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_5276", "content": "steroids [SEP] prednisolone recommended by the NASCIS 3 is the highest dose of steroids ever being used during a 2-day period for any clinical conditio", "tokenized_content": [2, 13039, 3, 22025, 6198, 2007, 1920, 16062, 1937, 23, 1977, 1920, 4554, 3253, 1927, 13039, 4264, 3301, 2251, 2409, 43, 22, 17, 3007, 3047, 1958, 2967, 2535, 8646, 2078, 1037, 3]}, "items": [{"id": "p_5276", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_5277", "content": "damage to the muscle [SEP] r any clinical condition. We hypothesize that it may cause some damage to the muscle of spinal cord injury patients. Further, steroid myopathy recov", "tokenized_content": [2, 4293, 1942, 1920, 3760, 3, 60, 2967, 2535, 2625, 18, 2038, 12880, 1988, 2176, 2278, 3936, 2673, 4293, 1942, 1920, 3760, 1927, 6071, 6670, 4047, 2132, 18, 2520, 16, 9507, 3]}, "items": [{"id": "p_5277", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_5278", "content": "steroid [SEP]  there was no mention regarding the possibility of acute corticosteroid myopathy that high-dose methylprednisolone may cause. The dosag", "tokenized_content": [2, 9507, 3, 2276, 1982, 2239, 14515, 4667, 1920, 5341, 1927, 3939, 17980, 25017, 1988, 2149, 17, 3253, 30087, 2278, 3936, 18, 1920, 4220, 2006, 3]}, "items": [{"id": "p_5278", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_5279", "content": "Alzheimer's disease [SEP] cits in central cholinergic functioning due to diseases such as Alzheimer's disease, yet correlations between central and peripheral responses have", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 12366, 1036, 1922, 4101, 13908, 7295, 2810, 1942, 3902, 2427, 1966, 9116, 11, 61, 2573, 16, 4898, 6100, 2192, 4101, 1930, 5009, 3387, 2162, 3]}, "items": [{"id": "p_5279", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_5280", "content": "tropicamide [SEP] died. This study assessed the effect of normal aging on (1) the tropicamide-induced increase in pupil diameter, and (2) the reversal of thi", "tokenized_content": [2, 29746, 5482, 3, 8545, 18, 2052, 2161, 3683, 1920, 2495, 1927, 2791, 6619, 1990, 12, 21, 13, 1920, 29746, 5482, 17, 2719, 2760, 1922, 19878, 5483, 16, 1930, 12, 22, 3]}, "items": [{"id": "p_5280", "content": "Tropicamide [SEP] One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholyt", "score": 1, "type": null, "tokenized_content": [2, 29746, 5482, 3, 2340, 1927, 1920, 20318, 10515, 1956, 17225, 4615, 2551, 1942, 24031, 1930, 2251, 4994, 1966, 1925, 21421, 5336, 2229, 9112, 26558, 1031, 3]}]}
{"query": {"id": "q_5281", "content": "pilocarpine [SEP] ase in pupil diameter, and (2) the reversal of this effect with pilocarpine. Scopolamine was used as a positive control to detect age-depen", "tokenized_content": [2, 7547, 7095, 12184, 3, 28826, 1922, 19878, 5483, 16, 1930, 12, 22, 13, 1920, 12393, 1927, 2052, 2495, 1956, 7547, 7095, 12184, 18, 25392, 10173, 25157, 1982, 2251, 1966, 43, 3]}, "items": [{"id": "p_5281", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_5282", "content": "Scopolamine [SEP] diameter, and (2) the reversal of this effect with pilocarpine. Scopolamine was used as a positive control to detect age-dependent changes ", "tokenized_content": [2, 25392, 10173, 25157, 3, 5483, 16, 1930, 12, 22, 13, 1920, 12393, 1927, 2052, 2495, 1956, 7547, 7095, 12184, 18, 25392, 10173, 25157, 1982, 2251, 1966, 43, 2843, 2285, 1942, 3]}, "items": [{"id": "p_5282", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_5283", "content": "scopolamine [SEP] in a randomized order. In 2 separate sessions, a single dose of scopolamine (0.5 mg, intravenously) or placebo was administered, and the ef", "tokenized_content": [2, 25392, 10173, 25157, 3, 1922, 43, 5542, 3238, 18, 1922, 22, 5850, 7544, 16, 43, 2957, 3253, 1927, 25392, 10173, 25157, 12, 20, 18, 25, 2786, 16, 15132, 13, 2014, 3]}, "items": [{"id": "p_5283", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_5284", "content": "impairment in word recall [SEP] inistration of tropicamide and pilocarpine; scopolamine-induced impairment in word recall. RESULTS: There was no significant difference between elderly a", "tokenized_content": [2, 6159, 1922, 5430, 8717, 3, 1922, 3934, 1927, 29746, 5482, 1930, 7547, 7095, 12184, 31, 25392, 10173, 25157, 17, 2719, 6159, 1922, 5430, 8717, 18, 2274, 30, 2276, 1982, 2239, 3]}, "items": [{"id": "p_5284", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_5285", "content": "Acetazolamide [SEP] Acetazolamide-induced Gerstmann syndrome.", "tokenized_content": [2, 4118, 21585, 2261, 3, 4118, 21585, 2261, 17, 2719, 9559, 2156, 8890, 4741, 18, 3]}, "items": [{"id": "p_5285", "content": "Acetazolamide [SEP] One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an", "score": 1, "type": null, "tokenized_content": [2, 4118, 21585, 2261, 3, 2340, 1927, 1920, 5056, 1935, 22018, 2051, 4472, 1988, 1977, 8929, 3655, 3316, 3905, 10060, 18, 2176, 1977, 8929, 4707, 2222, 1966, 1925, 3]}]}
{"query": {"id": "q_5286", "content": "Gerstmann syndrome [SEP] Acetazolamide-induced Gerstmann syndrome.", "tokenized_content": [2, 9559, 2156, 8890, 4741, 3, 4118, 21585, 2261, 17, 2719, 9559, 2156, 8890, 4741, 18, 3]}, "items": [{"id": "p_5286", "content": "Gerstmann Syndrome [SEP] A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. T", "score": 1, "type": null, "tokenized_content": [2, 9559, 2156, 8890, 4741, 3, 43, 4770, 1927, 10032, 4378, 2007, 1920, 12470, 1007, 1927, 8497, 21790, 27545, 1019, 16, 3890, 8854, 2126, 16, 3890, 23327, 13004, 1019, 16, 1930, 3659, 17, 3506, 2054, 29292, 18, 62, 3]}]}
{"query": {"id": "q_5287", "content": "confusion [SEP] Acute confusion induced by acetazolamide is a well known adverse drug reaction ", "tokenized_content": [2, 18272, 3, 3939, 18272, 2719, 2007, 4118, 21585, 2261, 1977, 43, 2486, 3171, 5246, 2838, 3227, 3]}, "items": [{"id": "p_5287", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_5288", "content": "acetazolamide [SEP] Acute confusion induced by acetazolamide is a well known adverse drug reaction in patients with renal im", "tokenized_content": [2, 4118, 21585, 2261, 3, 3939, 18272, 2719, 2007, 4118, 21585, 2261, 1977, 43, 2486, 3171, 5246, 2838, 3227, 1922, 2132, 1956, 4604, 2042, 3]}, "items": [{"id": "p_5288", "content": "Acetazolamide [SEP] One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an", "score": 1, "type": null, "tokenized_content": [2, 4118, 21585, 2261, 3, 2340, 1927, 1920, 5056, 1935, 22018, 2051, 4472, 1988, 1977, 8929, 3655, 3316, 3905, 10060, 18, 2176, 1977, 8929, 4707, 2222, 1966, 1925, 3]}]}
{"query": {"id": "q_5289", "content": "renal impairment [SEP] zolamide is a well known adverse drug reaction in patients with renal impairment. We report a case of acetazolamide-induced Gerstmann syndrome i", "tokenized_content": [2, 4604, 6159, 3, 21483, 5482, 1977, 43, 2486, 3171, 5246, 2838, 3227, 1922, 2132, 1956, 4604, 6159, 18, 2038, 3809, 43, 3087, 1927, 4118, 21585, 2261, 17, 2719, 9559, 2156, 3]}, "items": [{"id": "p_5289", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5290", "content": "Gerstmann syndrome [SEP] ith renal impairment. We report a case of acetazolamide-induced Gerstmann syndrome in a patient with normal renal function, to highlight predispos", "tokenized_content": [2, 9559, 2156, 8890, 4741, 3, 24737, 4604, 6159, 18, 2038, 3809, 43, 3087, 1927, 4118, 21585, 2261, 17, 2719, 9559, 2156, 8890, 4741, 1922, 43, 2774, 1956, 2791, 4604, 2347, 3]}, "items": [{"id": "p_5290", "content": "Gerstmann Syndrome [SEP] A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. T", "score": 1, "type": null, "tokenized_content": [2, 9559, 2156, 8890, 4741, 3, 43, 4770, 1927, 10032, 4378, 2007, 1920, 12470, 1007, 1927, 8497, 21790, 27545, 1019, 16, 3890, 8854, 2126, 16, 3890, 23327, 13004, 1019, 16, 1930, 3659, 17, 3506, 2054, 29292, 18, 62, 3]}]}
{"query": {"id": "q_5291", "content": "Hypomania [SEP] Hypomania-like syndrome induced by olanzapine.", "tokenized_content": [2, 22750, 12231, 3, 22750, 12231, 17, 3189, 4741, 2719, 2007, 26591, 18, 3]}, "items": [{"id": "p_5291", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_5292", "content": "olanzapine [SEP] Hypomania-like syndrome induced by olanzapine.", "tokenized_content": [2, 26591, 3, 22750, 12231, 17, 3189, 4741, 2719, 2007, 26591, 18, 3]}, "items": [{"id": "p_5292", "content": "olanzapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26591, 3, 3]}]}
{"query": {"id": "q_5293", "content": "psychotic disorder [SEP]  a female patient with a diagnosis of a not otherwise specified psychotic disorder (DSM-IV) who developed hypomania shortly after the introduction", "tokenized_content": [2, 16651, 4770, 3, 43, 4232, 2774, 1956, 43, 3574, 1927, 43, 2084, 7631, 9296, 16651, 4770, 12, 10964, 17, 4370, 13, 2746, 3530, 22750, 12231, 17002, 2256, 1920, 6935, 3]}, "items": [{"id": "p_5293", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_5294", "content": "hypomania [SEP] t otherwise specified psychotic disorder (DSM-IV) who developed hypomania shortly after the introduction of olanzapine treatment.", "tokenized_content": [2, 22750, 12231, 3, 62, 7631, 9296, 16651, 4770, 12, 10964, 17, 4370, 13, 2746, 3530, 22750, 12231, 17002, 2256, 1920, 6935, 1927, 26591, 2311, 18, 3]}, "items": [{"id": "p_5294", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_5295", "content": "olanzapine [SEP] M-IV) who developed hypomania shortly after the introduction of olanzapine treatment.", "tokenized_content": [2, 26591, 3, 55, 17, 4370, 13, 2746, 3530, 22750, 12231, 17002, 2256, 1920, 6935, 1927, 26591, 2311, 18, 3]}, "items": [{"id": "p_5295", "content": "olanzapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26591, 3, 3]}]}
{"query": {"id": "q_5296", "content": "superoxide [SEP] Neutrophil superoxide and hydrogen peroxide production in patients with acute liver f", "tokenized_content": [2, 10738, 3, 9460, 10738, 1930, 6201, 12316, 3372, 1922, 2132, 1956, 3939, 3568, 48, 3]}, "items": [{"id": "p_5296", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_5297", "content": "hydrogen peroxide [SEP] Neutrophil superoxide and hydrogen peroxide production in patients with acute liver failure.", "tokenized_content": [2, 6201, 12316, 3, 9460, 10738, 1930, 6201, 12316, 3372, 1922, 2132, 1956, 3939, 3568, 4574, 18, 3]}, "items": [{"id": "p_5297", "content": "Hydrogen Peroxide [SEP] A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unst", "score": 1, "type": null, "tokenized_content": [2, 6201, 12316, 3, 43, 3206, 23669, 5899, 2251, 1922, 8052, 3331, 1966, 43, 23739, 5899, 16, 6189, 2155, 16, 1930, 12259, 2246, 17, 20905, 18, 2176, 1977, 4322, 10769, 3]}]}
{"query": {"id": "q_5298", "content": "acute liver failure [SEP] il superoxide and hydrogen peroxide production in patients with acute liver failure.", "tokenized_content": [2, 3939, 3568, 4574, 3, 2614, 10738, 1930, 6201, 12316, 3372, 1922, 2132, 1956, 3939, 3568, 4574, 18, 3]}, "items": [{"id": "p_5298", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_5299", "content": "superoxide [SEP] Defects in superoxide and hydrogen peroxide production may be implicated in the high ", "tokenized_content": [2, 10738, 3, 6007, 1922, 10738, 1930, 6201, 12316, 3372, 2278, 1998, 6835, 1922, 1920, 2149, 3]}, "items": [{"id": "p_5299", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_5300", "content": "hydrogen peroxide [SEP] Defects in superoxide and hydrogen peroxide production may be implicated in the high incidence of bacterial", "tokenized_content": [2, 6201, 12316, 3, 6007, 1922, 10738, 1930, 6201, 12316, 3372, 2278, 1998, 6835, 1922, 1920, 2149, 4332, 1927, 4543, 3]}, "items": [{"id": "p_5300", "content": "Hydrogen Peroxide [SEP] A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unst", "score": 1, "type": null, "tokenized_content": [2, 6201, 12316, 3, 43, 3206, 23669, 5899, 2251, 1922, 8052, 3331, 1966, 43, 23739, 5899, 16, 6189, 2155, 16, 1930, 12259, 2246, 17, 20905, 18, 2176, 1977, 4322, 10769, 3]}]}
{"query": {"id": "q_5301", "content": "bacterial infections [SEP]  peroxide production may be implicated in the high incidence of bacterial infections in patients with acute liver failure (ALF). In the present stud", "tokenized_content": [2, 4543, 5024, 3, 12316, 3372, 2278, 1998, 6835, 1922, 1920, 2149, 4332, 1927, 4543, 5024, 1922, 2132, 1956, 3939, 3568, 4574, 12, 17913, 13, 18, 1922, 1920, 2481, 2060, 3]}, "items": [{"id": "p_5301", "content": "Bacterial Infections [SEP] Infections by bacteria, general or unspecified.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4543, 5024, 3, 5024, 2007, 4802, 16, 3335, 2014, 29628, 2828, 18, 3]}]}
{"query": {"id": "q_5302", "content": "acute liver failure [SEP]  in the high incidence of bacterial infections in patients with acute liver failure (ALF). In the present study, oxygen radical production in patie", "tokenized_content": [2, 3939, 3568, 4574, 3, 1922, 1920, 2149, 4332, 1927, 4543, 5024, 1922, 2132, 1956, 3939, 3568, 4574, 12, 17913, 13, 18, 1922, 1920, 2481, 2161, 16, 4612, 6917, 3372, 1922, 3]}, "items": [{"id": "p_5302", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_5303", "content": "ALF [SEP] e of bacterial infections in patients with acute liver failure (ALF). In the present study, oxygen radical production in patients w", "tokenized_content": [2, 17913, 3, 47, 1927, 4543, 5024, 1922, 2132, 1956, 3939, 3568, 4574, 12, 17913, 13, 18, 1922, 1920, 2481, 2161, 16, 4612, 6917, 3372, 1922, 2132, 65, 3]}, "items": [{"id": "p_5303", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_5304", "content": "oxygen [SEP]  patients with acute liver failure (ALF). In the present study, oxygen radical production in patients with ALF due to paracetamol over", "tokenized_content": [2, 4612, 3, 2132, 1956, 3939, 3568, 4574, 12, 17913, 13, 18, 1922, 1920, 2481, 2161, 16, 4612, 6917, 3372, 1922, 2132, 1956, 17913, 2810, 1942, 27021, 2338, 3]}, "items": [{"id": "p_5304", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_5305", "content": "paracetamol [SEP] nt study, oxygen radical production in patients with ALF due to paracetamol overdose was compared with that of healthy volunteers. Neutroph", "tokenized_content": [2, 27021, 3, 5891, 2161, 16, 4612, 6917, 3372, 1922, 2132, 1956, 17913, 2810, 1942, 27021, 21090, 1982, 2452, 1956, 1988, 1927, 4097, 9701, 18, 6400, 3]}, "items": [{"id": "p_5305", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_5306", "content": "overdose [SEP] ygen radical production in patients with ALF due to paracetamol overdose was compared with that of healthy volunteers. Neutrophils from ", "tokenized_content": [2, 21090, 3, 67, 2432, 6917, 3372, 1922, 2132, 1956, 17913, 2810, 1942, 27021, 21090, 1982, 2452, 1956, 1988, 1927, 4097, 9701, 18, 8508, 2037, 3]}, "items": [{"id": "p_5306", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_5307", "content": "Superoxide [SEP] nt receptors using zymosan opsonized with ALF or control serum. Superoxide and hydrogen peroxide production by ALF neutrophils stimulated ", "tokenized_content": [2, 10738, 3, 5891, 4086, 2193, 15856, 11201, 26303, 2301, 1956, 17913, 2014, 2285, 3256, 18, 10738, 1930, 6201, 12316, 3372, 2007, 17913, 8508, 5449, 3]}, "items": [{"id": "p_5307", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_5308", "content": "formyl-methionyl-leucyl-phenylalanine [SEP] and hydrogen peroxide production in neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine (fMLP) from a further 18 ALF patients was unaffected compared w", "tokenized_content": [2, 29285, 17, 2295, 2001, 2199, 17, 9906, 2199, 17, 17388, 3, 1930, 6201, 12316, 3372, 1922, 8508, 5449, 1956, 29285, 17, 2295, 2001, 2199, 17, 9906, 2199, 17, 17388, 12, 3]}, "items": [{"id": "p_5308", "content": "N-Formylmethionine Leucyl-Phenylalanine [SEP] A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocy", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 29285, 23568, 11215, 9906, 2199, 17, 17388, 3, 43, 29285, 1981, 8027, 8253, 10398, 3937, 2037, 4543, 26870, 1036, 1988, 1977, 6629, 20513, 1942, 29160, 9906, 3830, 3]}]}
{"query": {"id": "q_5309", "content": "fMLP [SEP] trophils stimulated with formyl-methionyl-leucyl-phenylalanine (fMLP) from a further 18 ALF patients was unaffected compared with co", "tokenized_content": [2, 5620, 13857, 3, 15112, 5002, 5449, 1956, 29285, 17, 2295, 2001, 2199, 17, 9906, 2199, 17, 17388, 12, 5620, 13857, 13, 2037, 43, 2520, 2654, 17913, 2132, 1982, 10403, 2452, 3]}, "items": [{"id": "p_5309", "content": "N-Formylmethionine Leucyl-Phenylalanine [SEP] A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocy", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 29285, 23568, 11215, 9906, 2199, 17, 17388, 3, 43, 29285, 1981, 8027, 8253, 10398, 3937, 2037, 4543, 26870, 1036, 1988, 1977, 6629, 20513, 1942, 29160, 9906, 3830, 3]}]}
{"query": {"id": "q_5310", "content": "sertraline [SEP] Absence of effect of sertraline on time-based sensitization of cognitive impairment with halope", "tokenized_content": [2, 17498, 7317, 2053, 3, 3905, 1927, 2495, 1927, 17498, 7317, 2053, 1990, 2367, 17, 2454, 12770, 1927, 4328, 6159, 1956, 23226, 9626, 3]}, "items": [{"id": "p_5310", "content": "Sertraline [SEP] A selective serotonin uptake inhibitor that is used in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17498, 7317, 2053, 3, 43, 5328, 11153, 5047, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_5311", "content": "cognitive impairment [SEP] Absence of effect of sertraline on time-based sensitization of cognitive impairment with haloperidol.", "tokenized_content": [2, 4328, 6159, 3, 3905, 1927, 2495, 1927, 17498, 7317, 2053, 1990, 2367, 17, 2454, 12770, 1927, 4328, 6159, 1956, 25107, 18, 3]}, "items": [{"id": "p_5311", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5312", "content": "haloperidol [SEP] raline on time-based sensitization of cognitive impairment with haloperidol.", "tokenized_content": [2, 25107, 3, 15906, 2053, 1990, 2367, 17, 2454, 12770, 1927, 4328, 6159, 1956, 25107, 18, 3]}, "items": [{"id": "p_5312", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5313", "content": "haloperidol [SEP] , randomized, placebo-controlled study evaluated the effects of haloperidol alone and haloperidol plus sertraline on cognitive and psychomo", "tokenized_content": [2, 25107, 3, 16, 5542, 16, 5936, 17, 4642, 2161, 3747, 1920, 2564, 1927, 25107, 4298, 1930, 25107, 5390, 17498, 7317, 2053, 1990, 4328, 1930, 18740, 12492, 3]}, "items": [{"id": "p_5313", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5314", "content": "sertraline [SEP] evaluated the effects of haloperidol alone and haloperidol plus sertraline on cognitive and psychomotor function in 24 healthy male subjec", "tokenized_content": [2, 17498, 7317, 2053, 3, 3747, 1920, 2564, 1927, 25107, 4298, 1930, 25107, 5390, 17498, 7317, 2053, 1990, 4328, 1930, 26261, 2347, 1922, 2686, 4097, 4005, 2846, 1940, 3]}, "items": [{"id": "p_5314", "content": "Sertraline [SEP] A selective serotonin uptake inhibitor that is used in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17498, 7317, 2053, 3, 43, 5328, 11153, 5047, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_5315", "content": "Impairment of cognitive function [SEP] er a 24-hour period after dosing on Days 1, 2, and 25. RESULTS: Impairment of cognitive function was observed 6 to 8 hours after administration of haloperidol o", "tokenized_content": [2, 6159, 1927, 4328, 2347, 3, 2668, 43, 2686, 17, 6231, 3047, 2256, 10654, 1990, 3000, 21, 16, 22, 16, 1930, 2637, 18, 2274, 30, 6159, 1927, 4328, 2347, 1982, 2528, 3]}, "items": [{"id": "p_5315", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5316", "content": "Haloperidol [SEP] profiles of sertraline and of placebo were similar. CONCLUSION: Haloperidol produced a clear profile of cognitive impairment that was not w", "tokenized_content": [2, 25107, 3, 5554, 1927, 17498, 7317, 2053, 1930, 1927, 5936, 1985, 2551, 18, 4180, 30, 25107, 4152, 43, 4021, 5174, 1927, 4328, 6159, 1988, 1982, 2084, 65, 3]}, "items": [{"id": "p_5316", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5317", "content": "cognitive impairment [SEP] re similar. CONCLUSION: Haloperidol produced a clear profile of cognitive impairment that was not worsened by concomitant sertraline administration.", "tokenized_content": [2, 4328, 6159, 3, 1964, 2551, 18, 4180, 30, 25107, 4152, 43, 4021, 5174, 1927, 4328, 6159, 1988, 1982, 2084, 22784, 2007, 8537, 17498, 7317, 2053, 4183, 18, 3]}, "items": [{"id": "p_5317", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5318", "content": "Ciprofloxacin [SEP] Ciprofloxacin-induced nephrotoxicity in patients with cancer.", "tokenized_content": [2, 18502, 3, 18502, 17, 2719, 27880, 1922, 2132, 1956, 2539, 18, 3]}, "items": [{"id": "p_5318", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_5319", "content": "nephrotoxicity [SEP] Ciprofloxacin-induced nephrotoxicity in patients with cancer.", "tokenized_content": [2, 27880, 3, 18502, 17, 2719, 27880, 1922, 2132, 1956, 2539, 18, 3]}, "items": [{"id": "p_5319", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5320", "content": "cancer [SEP] Ciprofloxacin-induced nephrotoxicity in patients with cancer.", "tokenized_content": [2, 2539, 3, 18502, 17, 2719, 27880, 1922, 2132, 1956, 2539, 18, 3]}, "items": [{"id": "p_5320", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5321", "content": "Nephrotoxicity [SEP] Nephrotoxicity associated with ciprofloxacin is uncommon. Five patients with c", "tokenized_content": [2, 27880, 3, 27880, 2458, 1956, 18502, 1977, 14403, 18, 3628, 2132, 1956, 45, 3]}, "items": [{"id": "p_5321", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5322", "content": "ciprofloxacin [SEP] Nephrotoxicity associated with ciprofloxacin is uncommon. Five patients with cancer who developed acute rena", "tokenized_content": [2, 18502, 3, 27880, 2458, 1956, 18502, 1977, 14403, 18, 3628, 2132, 1956, 2539, 2746, 3530, 3939, 3866, 1019, 3]}, "items": [{"id": "p_5322", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_5323", "content": "cancer [SEP] y associated with ciprofloxacin is uncommon. Five patients with cancer who developed acute renal failure that followed treatment with ", "tokenized_content": [2, 2539, 3, 67, 2458, 1956, 18502, 1977, 14403, 18, 3628, 2132, 1956, 2539, 2746, 3530, 3939, 4604, 4574, 1988, 3489, 2311, 1956, 3]}, "items": [{"id": "p_5323", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5324", "content": "acute renal failure [SEP] rofloxacin is uncommon. Five patients with cancer who developed acute renal failure that followed treatment with ciprofloxacin are described and an", "tokenized_content": [2, 3939, 4604, 4574, 3, 3039, 14217, 1977, 14403, 18, 3628, 2132, 1956, 2539, 2746, 3530, 3939, 4604, 4574, 1988, 3489, 2311, 1956, 18502, 2032, 2910, 1930, 1925, 3]}, "items": [{"id": "p_5324", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5325", "content": "creatinine [SEP] d in the literature are reviewed. Other than elevation of serum creatinine levels, characteristic clinical manifestations and abnormal lab", "tokenized_content": [2, 9374, 3, 46, 1922, 1920, 4431, 2032, 5487, 18, 2303, 2254, 8644, 1927, 3256, 9374, 2428, 16, 6293, 2535, 10952, 1930, 4552, 2857, 3]}, "items": [{"id": "p_5325", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_5326", "content": "interstitial nephritis [SEP] normal laboratory findings are not frequently present. Allergic interstitial nephritis is believed to be the underlying pathological-process. Definiti", "tokenized_content": [2, 11584, 25064, 3, 2791, 4542, 3056, 2032, 2084, 5467, 2481, 18, 10519, 11584, 25064, 1977, 9283, 1942, 1998, 1920, 5030, 6598, 17, 2585, 18, 5317, 2078, 3]}, "items": [{"id": "p_5326", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_5327", "content": "pentamidine [SEP] Case report: pentamidine and polymorphic ventricular tachycardia revisited.", "tokenized_content": [2, 9412, 25238, 2053, 3, 3087, 3809, 30, 9412, 25238, 2053, 1930, 14240, 6493, 17397, 26084, 2599, 18, 3]}, "items": [{"id": "p_5327", "content": "Pentamidine [SEP] Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS p", "score": 1, "type": null, "tokenized_content": [2, 9412, 25238, 2053, 3, 2246, 9218, 15449, 1024, 5899, 3655, 1922, 13479, 23491, 16, 25040, 16, 1930, 2673, 8697, 5024, 31, 2251, 1922, 2311, 1927, 6097, 22972, 58, 3]}]}
{"query": {"id": "q_5328", "content": "ventricular tachycardia [SEP] Case report: pentamidine and polymorphic ventricular tachycardia revisited.", "tokenized_content": [2, 6493, 17397, 3, 3087, 3809, 30, 9412, 25238, 2053, 1930, 14240, 6493, 17397, 26084, 2599, 18, 3]}, "items": [{"id": "p_5328", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_5329", "content": "Pentamidine isethionate [SEP] Pentamidine isethionate has been associated with ventricular tachyarrhythmias, includin", "tokenized_content": [2, 9412, 25238, 2053, 1977, 3184, 18965, 3, 9412, 25238, 2053, 1977, 3184, 18965, 2258, 2252, 2458, 1956, 6493, 12762, 9771, 18858, 10245, 15519, 16, 2327, 1921, 3]}, "items": [{"id": "p_5329", "content": "Pentamidine [SEP] Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS p", "score": 1, "type": null, "tokenized_content": [2, 9412, 25238, 2053, 3, 2246, 9218, 15449, 1024, 5899, 3655, 1922, 13479, 23491, 16, 25040, 16, 1930, 2673, 8697, 5024, 31, 2251, 1922, 2311, 1927, 6097, 22972, 58, 3]}]}
{"query": {"id": "q_5330", "content": "ventricular tachyarrhythmias [SEP] Pentamidine isethionate has been associated with ventricular tachyarrhythmias, including torsade de pointes. This article reports two cases o", "tokenized_content": [2, 6493, 12762, 9771, 18858, 10245, 15519, 3, 9412, 25238, 2053, 1977, 3184, 18965, 2258, 2252, 2458, 1956, 6493, 12762, 9771, 18858, 10245, 15519, 16, 2710, 14823, 2873, 2028, 3575, 1918, 3]}, "items": [{"id": "p_5330", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_5331", "content": "torsade de pointes [SEP] as been associated with ventricular tachyarrhythmias, including torsade de pointes. This article reports two cases of this complication and review", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 1966, 2252, 2458, 1956, 6493, 12762, 9771, 18858, 10245, 15519, 16, 2710, 14823, 2873, 2028, 3575, 1918, 18, 2052, 5868, 4710, 2288, 2919, 1927, 3]}, "items": [{"id": "p_5331", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_5332", "content": "Pentamidine [SEP] Pentamidine isethionate has been associated with ventricular tachyarrhythmi", "tokenized_content": [2, 9412, 25238, 2053, 3, 9412, 25238, 2053, 1977, 3184, 18965, 2258, 2252, 2458, 1956, 6493, 12762, 9771, 18858, 10245, 7395, 3]}, "items": [{"id": "p_5332", "content": "Pentamidine [SEP] Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS p", "score": 1, "type": null, "tokenized_content": [2, 9412, 25238, 2053, 3, 2246, 9218, 15449, 1024, 5899, 3655, 1922, 13479, 23491, 16, 25040, 16, 1930, 2673, 8697, 5024, 31, 2251, 1922, 2311, 1927, 6097, 22972, 58, 3]}]}
{"query": {"id": "q_5333", "content": "magnesium [SEP]  Pentamidine-induced torsade de pointes may be related to serum magnesium levels and hypomagnesemia may synergistically induce torsade. T", "tokenized_content": [2, 13148, 3, 9412, 25238, 2053, 17, 2719, 14823, 2873, 2028, 3575, 1918, 2278, 1998, 2712, 1942, 3256, 13148, 2428, 1930, 22750, 2531, 2124, 6026, 2278, 19766, 4769, 14823, 2873, 18, 3]}, "items": [{"id": "p_5333", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_5334", "content": "hypomagnesemia [SEP] torsade de pointes may be related to serum magnesium levels and hypomagnesemia may synergistically induce torsade. Torsade de pointes occurred", "tokenized_content": [2, 22750, 2531, 2124, 6026, 3, 14823, 2873, 2028, 3575, 1918, 2278, 1998, 2712, 1942, 3256, 13148, 2428, 1930, 22750, 2531, 2124, 6026, 2278, 19766, 4769, 14823, 2873, 18, 14823, 2873, 3]}, "items": [{"id": "p_5334", "content": "Hypomagnesemia primary [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22750, 2531, 2124, 6026, 3065, 3, 3]}]}
{"query": {"id": "q_5335", "content": "Torsade de pointes [SEP] m levels and hypomagnesemia may synergistically induce torsade. Torsade de pointes occurred after an average of 10 days of treatment with pentamid", "tokenized_content": [2, 14823, 2873, 2028, 3575, 1918, 3, 55, 2428, 1930, 22750, 2531, 2124, 6026, 2278, 19766, 4769, 14823, 2873, 18, 14823, 2873, 2028, 3575, 1918, 4807, 2256, 1925, 3361, 1927, 2119, 3]}, "items": [{"id": "p_5335", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_5336", "content": "pentamidine [SEP]  pointes occurred after an average of 10 days of treatment with pentamidine. In these patients, no other acute side effects of pentamidine ", "tokenized_content": [2, 9412, 25238, 2053, 3, 3575, 1918, 4807, 2256, 1925, 3361, 1927, 2119, 3000, 1927, 2311, 1956, 9412, 25238, 2053, 18, 1922, 2144, 2132, 16, 2239, 2303, 3939, 4159, 2564, 1927, 3]}, "items": [{"id": "p_5336", "content": "Pentamidine [SEP] Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS p", "score": 1, "type": null, "tokenized_content": [2, 9412, 25238, 2053, 3, 2246, 9218, 15449, 1024, 5899, 3655, 1922, 13479, 23491, 16, 25040, 16, 1930, 2673, 8697, 5024, 31, 2251, 1922, 2311, 1927, 6097, 22972, 58, 3]}]}
{"query": {"id": "q_5337", "content": "QTc interval prolongation [SEP] ed early, possibly without discontinuation of pentamidine. When QTc interval prolongation is observed, early magnesium supplementation is advocated.", "tokenized_content": [2, 23946, 4979, 20334, 3, 3347, 3120, 16, 6553, 2979, 14775, 1927, 9412, 25238, 2053, 18, 2469, 23946, 4979, 20334, 1977, 2528, 16, 3120, 13148, 8746, 1977, 24918, 18, 3]}, "items": [{"id": "p_5337", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_5338", "content": "malondialdehyde [SEP] Time dependence of plasma malondialdehyde, oxypurines, and nucleosides during incomplete cerebral ischemi", "tokenized_content": [2, 24270, 3, 2367, 6816, 1927, 3582, 24270, 16, 20004, 1034, 17687, 1036, 16, 1930, 18015, 1036, 2409, 9876, 6329, 5151, 1987, 1033, 3]}, "items": [{"id": "p_5338", "content": "Malondialdehyde [SEP] The dialdehyde of malonic acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24270, 3, 1920, 7588, 6542, 1927, 3054, 3490, 2687, 18, 3]}]}
{"query": {"id": "q_5339", "content": "nucleosides [SEP] Time dependence of plasma malondialdehyde, oxypurines, and nucleosides during incomplete cerebral ischemia in the rat.", "tokenized_content": [2, 18015, 1036, 3, 2367, 6816, 1927, 3582, 24270, 16, 20004, 1034, 17687, 1036, 16, 1930, 18015, 1036, 2409, 9876, 6329, 7716, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_5339", "content": "Nucleosides [SEP] Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 18015, 1036, 3, 19700, 2014, 21611, 11137, 8765, 1942, 43, 17870, 2014, 26405, 2217, 18, 12, 2037, 10721, 10, 17725, 1036, 11937, 16, 43, 29815, 1927, 10072, 16, 18117, 3347, 13, 3]}]}
{"query": {"id": "q_5340", "content": "cerebral ischemia [SEP]  malondialdehyde, oxypurines, and nucleosides during incomplete cerebral ischemia in the rat.", "tokenized_content": [2, 6329, 7716, 3, 24270, 16, 20004, 1034, 17687, 1036, 16, 1930, 18015, 1036, 2409, 9876, 6329, 7716, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_5340", "content": "Brain Ischemia [SEP] Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs ", "score": 1, "type": null, "tokenized_content": [2, 3068, 7716, 3, 6579, 3378, 1927, 2877, 3426, 1942, 3068, 2960, 2810, 1942, 6624, 10849, 2014, 5510, 26497, 1915, 9049, 18, 2052, 5467, 5110, 3]}]}
{"query": {"id": "q_5341", "content": "cerebral ischemia [SEP] Incomplete cerebral ischemia (30 min) was induced in the rat by bilaterally clamping the com", "tokenized_content": [2, 6329, 7716, 3, 9876, 6329, 7716, 12, 2627, 2360, 13, 1982, 2719, 1922, 1920, 3067, 2007, 19092, 27981, 1920, 2008, 3]}, "items": [{"id": "p_5341", "content": "Brain Ischemia [SEP] Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs ", "score": 1, "type": null, "tokenized_content": [2, 3068, 7716, 3, 6579, 3378, 1927, 2877, 3426, 1942, 3068, 2960, 2810, 1942, 6624, 10849, 2014, 5510, 26497, 1915, 9049, 18, 2052, 5467, 5110, 3]}]}
{"query": {"id": "q_5342", "content": "ischemia [SEP] Incomplete cerebral ischemia (30 min) was induced in the rat by bilaterally clamping the com", "tokenized_content": [2, 7716, 3, 9876, 6329, 7716, 12, 2627, 2360, 13, 1982, 2719, 1922, 1920, 3067, 2007, 19092, 27981, 1920, 2008, 3]}, "items": [{"id": "p_5342", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_5343", "content": "malondialdehyde [SEP] e liquid chromatographic method for the direct determination of malondialdehyde, oxypurines, and nucleosides. During ischemia, a time-dependent", "tokenized_content": [2, 24270, 3, 47, 5875, 16818, 2417, 1958, 1920, 3083, 7063, 1927, 24270, 16, 20004, 1034, 17687, 1036, 16, 1930, 18015, 1036, 18, 2409, 7716, 16, 43, 2367, 17, 3100, 3]}, "items": [{"id": "p_5343", "content": "Malondialdehyde [SEP] The dialdehyde of malonic acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24270, 3, 1920, 7588, 6542, 1927, 3054, 3490, 2687, 18, 3]}]}
{"query": {"id": "q_5344", "content": "nucleosides [SEP] or the direct determination of malondialdehyde, oxypurines, and nucleosides. During ischemia, a time-dependent increase of plasma oxypurine", "tokenized_content": [2, 18015, 1036, 3, 2014, 1920, 3083, 7063, 1927, 24270, 16, 20004, 1034, 17687, 1036, 16, 1930, 18015, 1036, 18, 2409, 7716, 16, 43, 2367, 17, 3100, 2760, 1927, 3582, 20004, 3]}, "items": [{"id": "p_5344", "content": "Nucleosides [SEP] Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 18015, 1036, 3, 19700, 2014, 21611, 11137, 8765, 1942, 43, 17870, 2014, 26405, 2217, 18, 12, 2037, 10721, 10, 17725, 1036, 11937, 16, 43, 29815, 1927, 10072, 16, 18117, 3347, 13, 3]}]}
{"query": {"id": "q_5345", "content": "acetylsalicylate [SEP] el, one receiving 20 mg/kg b.w. of the cyclooxygenase inhibitor acetylsalicylate intravenously immediately before ischemia, the other receiving ", "tokenized_content": [2, 6894, 23880, 1935, 9075, 3, 2349, 16, 2340, 5962, 2036, 2786, 19, 3621, 44, 18, 65, 18, 1927, 1920, 21271, 4106, 6894, 23880, 1935, 9075, 15132, 6183, 3119, 7716, 16, 3]}, "items": [{"id": "p_5345", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_5346", "content": "hypotensive [SEP] ore ischemia, the other receiving 650 micrograms/kg b.w. of the hypotensive drug nitroprusside at a flow rate of 103 microliters/min intrav", "tokenized_content": [2, 12201, 3766, 3, 20237, 7716, 16, 1920, 2303, 5962, 18529, 13362, 19, 3621, 44, 18, 65, 18, 1927, 1920, 12201, 3766, 2838, 8686, 2047, 3468, 2261, 2019, 43, 3426, 2769, 3]}, "items": [{"id": "p_5346", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_5347", "content": "nitroprusside [SEP]  other receiving 650 micrograms/kg b.w. of the hypotensive drug nitroprusside at a flow rate of 103 microliters/min intravenously during isch", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 2303, 5962, 18529, 13362, 19, 3621, 44, 18, 65, 18, 1927, 1920, 12201, 3766, 2838, 8686, 2047, 3468, 2261, 2019, 43, 3426, 2769, 1927, 9373, 3]}, "items": [{"id": "p_5347", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_5348", "content": "ischemic [SEP] o monitor the metabolic alterations of tissues occurring during ischemic phenomena.(ABSTRACT TRUNCATED AT 250 WORDS)", "tokenized_content": [2, 7427, 3, 57, 8434, 1920, 4487, 5996, 1927, 3878, 6966, 2409, 7427, 12616, 18, 12, 10929, 9530, 2019, 6330, 6906, 13, 3]}, "items": [{"id": "p_5348", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_5349", "content": "toxicity [SEP] Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye ", "tokenized_content": [2, 5532, 3, 13908, 5532, 3864, 2037, 10046, 24893, 1927, 10934, 22523, 2688, 2010, 14220, 5723, 3]}, "items": [{"id": "p_5349", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5350", "content": "echothiophate iodide [SEP] Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops.", "tokenized_content": [2, 10934, 22523, 2688, 2010, 14220, 3, 13908, 5532, 3864, 2037, 10046, 24893, 1927, 10934, 22523, 2688, 2010, 14220, 5723, 15867, 18, 3]}, "items": [{"id": "p_5350", "content": "Echothiophate Iodide [SEP] A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10934, 22523, 2688, 2010, 14220, 3, 43, 6828, 16, 2815, 17, 8290, 15440, 2156, 7124, 4127, 4106, 2251, 1966, 43, 6519, 3153, 1922, 1920, 2311, 1927, 12106, 18, 3]}]}
{"query": {"id": "q_5351", "content": "echothiophate iodide [SEP] patient developed a severe cholinergic syndrome from the use of echothiophate iodide ophthalmic drops, presented with profound muscle weakness and w", "tokenized_content": [2, 10934, 22523, 2688, 2010, 14220, 3, 2774, 3530, 43, 4010, 13908, 4741, 2037, 1920, 2485, 1927, 10934, 22523, 2688, 2010, 14220, 21421, 15867, 16, 3549, 1956, 11098, 3760, 12175, 1930, 3]}, "items": [{"id": "p_5351", "content": "Echothiophate Iodide [SEP] A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10934, 22523, 2688, 2010, 14220, 3, 43, 6828, 16, 2815, 17, 8290, 15440, 2156, 7124, 4127, 4106, 2251, 1966, 43, 6519, 3153, 1922, 1920, 2311, 1927, 12106, 18, 3]}]}
{"query": {"id": "q_5352", "content": "muscle weakness [SEP]  echothiophate iodide ophthalmic drops, presented with profound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red", "tokenized_content": [2, 3760, 12175, 3, 10934, 22523, 2688, 2010, 14220, 21421, 15867, 16, 3549, 1956, 11098, 3760, 12175, 1930, 1982, 6370, 3258, 1920, 3574, 1927, 3057, 27618, 8572, 12413, 1937, 18, 2312, 3]}, "items": [{"id": "p_5352", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_5353", "content": "myasthenia gravis [SEP] ofound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red blood cell and serum cholinesterase levels were severely d", "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 1927, 2232, 3760, 12175, 1930, 1982, 6370, 3258, 1920, 3574, 1927, 3057, 27618, 8572, 12413, 1937, 18, 2312, 2877, 2024, 1930, 3256, 15440, 2156, 3]}, "items": [{"id": "p_5353", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_5354", "content": "Acute renal failure [SEP] Acute renal failure in high dose carboplatin chemotherapy.", "tokenized_content": [2, 3939, 4604, 4574, 3, 3939, 4604, 4574, 1922, 2149, 3253, 20072, 5318, 18, 3]}, "items": [{"id": "p_5354", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5355", "content": "carboplatin [SEP] Acute renal failure in high dose carboplatin chemotherapy.", "tokenized_content": [2, 20072, 3, 3939, 4604, 4574, 1922, 2149, 3253, 20072, 5318, 18, 3]}, "items": [{"id": "p_5355", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_5356", "content": "Carboplatin [SEP] Carboplatin has been reported to cause acute renal failure when administere", "tokenized_content": [2, 20072, 3, 20072, 2258, 2252, 2568, 1942, 3936, 3939, 4604, 4574, 2469, 15487, 1021, 3]}, "items": [{"id": "p_5356", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_5357", "content": "acute renal failure [SEP] Carboplatin has been reported to cause acute renal failure when administered in high doses to adult patients. We report a ", "tokenized_content": [2, 3939, 4604, 4574, 3, 20072, 2258, 2252, 2568, 1942, 3936, 3939, 4604, 4574, 2469, 5254, 1922, 2149, 5312, 1942, 4160, 2132, 18, 2038, 3809, 43, 3]}, "items": [{"id": "p_5357", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5358", "content": "carboplatin [SEP]  We report a 4 1/2-year-old girl who was treated with high-dose carboplatin for metastatic parameningeal embryonal rhabdomyosarcoma. Acute ", "tokenized_content": [2, 20072, 3, 2038, 3809, 43, 24, 21, 19, 22, 17, 2476, 17, 4156, 21676, 2746, 1982, 2868, 1956, 2149, 17, 3253, 20072, 1958, 6476, 3167, 3291, 5243, 9222, 3163, 25369, 3]}, "items": [{"id": "p_5358", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_5359", "content": "embryonal rhabdomyosarcoma [SEP] treated with high-dose carboplatin for metastatic parameningeal embryonal rhabdomyosarcoma. Acute renal failure developed followed by a slow partial recov", "tokenized_content": [2, 9222, 3163, 25369, 13063, 3, 2868, 1956, 2149, 17, 3253, 20072, 1958, 6476, 3167, 3291, 5243, 9222, 3163, 25369, 13063, 18, 3939, 4604, 4574, 3530, 3489, 2007, 43, 5470, 5740, 3]}, "items": [{"id": "p_5359", "content": "Rhabdomyosarcoma, Embryonal [SEP] A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The ce", "score": 1, "type": null, "tokenized_content": [2, 25369, 13063, 16, 9222, 3163, 3, 43, 2386, 1927, 25369, 13063, 11894, 5985, 1922, 1920, 4469, 1930, 7467, 16, 4369, 1920, 14905, 16, 1927, 3069, 4535, 1920, 2632, 1927, 2119, 18, 1920, 5827, 3]}]}
{"query": {"id": "q_5360", "content": "Acute renal failure [SEP] platin for metastatic parameningeal embryonal rhabdomyosarcoma. Acute renal failure developed followed by a slow partial recovery of renal function", "tokenized_content": [2, 3939, 4604, 4574, 3, 13003, 1958, 6476, 3167, 3291, 5243, 9222, 3163, 25369, 13063, 18, 3939, 4604, 4574, 3530, 3489, 2007, 43, 5470, 5740, 5241, 1927, 4604, 2347, 3]}, "items": [{"id": "p_5360", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5361", "content": "Endometrial carcinoma [SEP] Endometrial carcinoma after Hodgkin disease in childhood.", "tokenized_content": [2, 11634, 5373, 3, 11634, 5373, 2256, 17447, 2573, 1922, 7238, 18, 3]}, "items": [{"id": "p_5361", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_5362", "content": "Hodgkin disease [SEP] Endometrial carcinoma after Hodgkin disease in childhood.", "tokenized_content": [2, 17447, 2573, 3, 11634, 5373, 2256, 17447, 2573, 1922, 7238, 18, 3]}, "items": [{"id": "p_5362", "content": "Hodgkin Disease [SEP] A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the cla", "score": 1, "type": null, "tokenized_content": [2, 17447, 2573, 3, 43, 6558, 2573, 4378, 2007, 7529, 16363, 1927, 1920, 3541, 6263, 16, 8380, 16, 1930, 3335, 11751, 2960, 18, 1922, 1920, 6958, 3]}]}
{"query": {"id": "q_5363", "content": "endometrial carcinoma [SEP] A 34-year-old patient developed metastic endometrial carcinoma after Hodgkin disease in childhood. She had ovarian failure aft", "tokenized_content": [2, 11634, 5373, 3, 43, 3540, 17, 2476, 17, 4156, 2774, 3530, 4025, 1935, 11634, 5373, 2256, 17447, 2573, 1922, 7238, 18, 4693, 2430, 6751, 4574, 2221, 1031, 3]}, "items": [{"id": "p_5363", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_5364", "content": "Hodgkin disease [SEP] year-old patient developed metastic endometrial carcinoma after Hodgkin disease in childhood. She had ovarian failure after abdominal irradiati", "tokenized_content": [2, 17447, 2573, 3, 2476, 17, 4156, 2774, 3530, 4025, 1935, 11634, 5373, 2256, 17447, 2573, 1922, 7238, 18, 4693, 2430, 6751, 4574, 2256, 6900, 6117, 1968, 3]}, "items": [{"id": "p_5364", "content": "Hodgkin Disease [SEP] A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the cla", "score": 1, "type": null, "tokenized_content": [2, 17447, 2573, 3, 43, 6558, 2573, 4378, 2007, 7529, 16363, 1927, 1920, 3541, 6263, 16, 8380, 16, 1930, 3335, 11751, 2960, 18, 1922, 1920, 6958, 3]}]}
{"query": {"id": "q_5365", "content": "ovarian failure [SEP] dometrial carcinoma after Hodgkin disease in childhood. She had ovarian failure after abdominal irradiation and chemotherapy for Hodgkin diseas", "tokenized_content": [2, 6751, 4574, 3, 2804, 2588, 2086, 5373, 2256, 17447, 2573, 1922, 7238, 18, 4693, 2430, 6751, 4574, 2256, 6900, 7759, 1930, 5318, 1958, 17447, 2445, 1934, 3]}, "items": [{"id": "p_5365", "content": "Ovarian Diseases [SEP] Pathological processes of the OVARY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6751, 3902, 3, 6598, 4028, 1927, 1920, 13464, 18, 3]}]}
{"query": {"id": "q_5366", "content": "estrogens [SEP] on and chemotherapy for Hodgkin disease, and received exogenous estrogens, a treatment implicated in the development of endometrial cance", "tokenized_content": [2, 20470, 3, 1990, 1930, 5318, 1958, 17447, 2573, 16, 1930, 4004, 8278, 20470, 16, 43, 2311, 6835, 1922, 1920, 2740, 1927, 11634, 2112, 1972, 3]}, "items": [{"id": "p_5366", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_5367", "content": "endometrial cancer [SEP] ogenous estrogens, a treatment implicated in the development of endometrial cancer in menopausal women. Young women on replacement estrogens for o", "tokenized_content": [2, 11634, 2539, 3, 17395, 5200, 20470, 16, 43, 2311, 6835, 1922, 1920, 2740, 1927, 11634, 2539, 1922, 17779, 3089, 18, 4201, 3089, 1990, 7619, 20470, 1958, 57, 3]}, "items": [{"id": "p_5367", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_5368", "content": "cancer [SEP] ogens, a treatment implicated in the development of endometrial cancer in menopausal women. Young women on replacement estrogens for o", "tokenized_content": [2, 2539, 3, 17395, 2099, 16, 43, 2311, 6835, 1922, 1920, 2740, 1927, 11634, 2539, 1922, 17779, 3089, 18, 4201, 3089, 1990, 7619, 20470, 1958, 57, 3]}, "items": [{"id": "p_5368", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5369", "content": "obstructive sleep apnea syndrome [SEP] Induction of the obstructive sleep apnea syndrome in a woman by exogenous androgen administration.", "tokenized_content": [2, 12234, 5006, 17578, 4741, 3, 4408, 1927, 1920, 12234, 5006, 17578, 4741, 1922, 43, 10440, 2007, 8278, 10817, 4183, 18, 3]}, "items": [{"id": "p_5369", "content": "Sleep Apnea, Obstructive [SEP] A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obst", "score": 1, "type": null, "tokenized_content": [2, 5006, 17578, 16, 12234, 3, 43, 4770, 4378, 2007, 7457, 17578, 1036, 2409, 5006, 4281, 7733, 5481, 6905, 18, 2176, 1977, 2810, 1942, 5199, 8155, 9953, 3]}]}
{"query": {"id": "q_5370", "content": "androgen [SEP] of the obstructive sleep apnea syndrome in a woman by exogenous androgen administration.", "tokenized_content": [2, 10817, 3, 1927, 1920, 12234, 5006, 17578, 4741, 1922, 43, 10440, 2007, 8278, 10817, 4183, 18, 3]}, "items": [{"id": "p_5370", "content": "Androgens [SEP] Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. D", "score": 1, "type": null, "tokenized_content": [2, 22079, 3, 4300, 1988, 6310, 1956, 10817, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 10592, 18, 46, 3]}]}
{"query": {"id": "q_5371", "content": "syndrome of obstructive sleep apnea [SEP] in a 54-yr-old woman who had developed physical changes and the syndrome of obstructive sleep apnea while being administered exogenous androgens. When the androgen", "tokenized_content": [2, 4741, 1927, 12234, 5006, 17578, 3, 1922, 43, 4584, 17, 13031, 17, 4156, 10440, 2746, 2430, 3530, 3841, 2840, 1930, 1920, 4741, 1927, 12234, 5006, 17578, 2679, 3301, 5254, 8278, 3]}, "items": [{"id": "p_5371", "content": "Sleep Apnea, Obstructive [SEP] A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obst", "score": 1, "type": null, "tokenized_content": [2, 5006, 17578, 16, 12234, 3, 43, 4770, 4378, 2007, 7457, 17578, 1036, 2409, 5006, 4281, 7733, 5481, 6905, 18, 2176, 1977, 2810, 1942, 5199, 8155, 9953, 3]}]}
{"query": {"id": "q_5372", "content": "androgens [SEP] e of obstructive sleep apnea while being administered exogenous androgens. When the androgens were withdrawn, the patient's physical chan", "tokenized_content": [2, 22079, 3, 47, 1927, 12234, 5006, 17578, 2679, 3301, 5254, 8278, 22079, 18, 2469, 1920, 22079, 1985, 19540, 16, 1920, 2774, 11, 61, 3841, 2354, 3]}, "items": [{"id": "p_5372", "content": "Androgens [SEP] Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. D", "score": 1, "type": null, "tokenized_content": [2, 22079, 3, 4300, 1988, 6310, 1956, 10817, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 10592, 18, 46, 3]}]}
{"query": {"id": "q_5373", "content": "androgen [SEP] e of obstructive sleep apnea while being administered exogenous androgens. When the androgens were withdrawn, the patient's physical cha", "tokenized_content": [2, 10817, 3, 47, 1927, 12234, 5006, 17578, 2679, 3301, 5254, 8278, 22079, 18, 2469, 1920, 22079, 1985, 19540, 16, 1920, 2774, 11, 61, 3841, 13297, 3]}, "items": [{"id": "p_5373", "content": "Androgens [SEP] Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. D", "score": 1, "type": null, "tokenized_content": [2, 22079, 3, 4300, 1988, 6310, 1956, 10817, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 10592, 18, 46, 3]}]}
{"query": {"id": "q_5374", "content": "obstructive sleep apnea [SEP] ld woman who had developed physical changes and the syndrome of obstructive sleep apnea while being administered exogenous androgens. When the androgen", "tokenized_content": [2, 12234, 5006, 17578, 3, 5091, 10440, 2746, 2430, 3530, 3841, 2840, 1930, 1920, 4741, 1927, 12234, 5006, 17578, 2679, 3301, 5254, 8278, 22079, 18, 2469, 1920, 10817, 3]}, "items": [{"id": "p_5374", "content": "Sleep Apnea, Obstructive [SEP] A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obst", "score": 1, "type": null, "tokenized_content": [2, 5006, 17578, 16, 12234, 3, 43, 4770, 4378, 2007, 7457, 17578, 1036, 2409, 5006, 4281, 7733, 5481, 6905, 18, 2176, 1977, 2810, 1942, 5199, 8155, 9953, 3]}]}
{"query": {"id": "q_5375", "content": "sleep apnea [SEP]  had developed physical changes and the syndrome of obstructive sleep apnea while being administered exogenous androgens. When the androgen", "tokenized_content": [2, 5006, 17578, 3, 2430, 3530, 3841, 2840, 1930, 1920, 4741, 1927, 12234, 5006, 17578, 2679, 3301, 5254, 8278, 22079, 18, 2469, 1920, 10817, 3]}, "items": [{"id": "p_5375", "content": "Sleep Apnea Syndromes [SEP] Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the ", "score": 1, "type": null, "tokenized_content": [2, 5006, 17578, 12688, 3, 4414, 4378, 2007, 3137, 10975, 1036, 1927, 11695, 1036, 2409, 5006, 1988, 4769, 5740, 14216, 1036, 1930, 11827, 1956, 1920, 3]}]}
{"query": {"id": "q_5376", "content": "obstructive sleep apnea syndrome [SEP] hat predisposes to obstruction during sleep. Development of the obstructive sleep apnea syndrome must be considered a possible side effect of androgen therapy.", "tokenized_content": [2, 12234, 5006, 17578, 4741, 3, 16133, 23002, 1036, 1942, 10849, 2409, 5006, 18, 2740, 1927, 1920, 12234, 5006, 17578, 4741, 4902, 1998, 3311, 43, 3216, 4159, 2495, 1927, 10817, 3181, 3]}, "items": [{"id": "p_5376", "content": "Sleep Apnea, Obstructive [SEP] A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obst", "score": 1, "type": null, "tokenized_content": [2, 5006, 17578, 16, 12234, 3, 43, 4770, 4378, 2007, 7457, 17578, 1036, 2409, 5006, 4281, 7733, 5481, 6905, 18, 2176, 1977, 2810, 1942, 5199, 8155, 9953, 3]}]}
{"query": {"id": "q_5377", "content": "captopril [SEP] Effect of captopril on pre-existing and aminonucleoside-induced proteinuria in spon", "tokenized_content": [2, 7502, 24863, 3, 2495, 1927, 7502, 24863, 1990, 2097, 17, 6124, 1930, 3835, 1022, 2626, 8028, 17, 2719, 15831, 1922, 18055, 1022, 3]}, "items": [{"id": "p_5377", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_5378", "content": "aminonucleoside [SEP] Effect of captopril on pre-existing and aminonucleoside-induced proteinuria in spontaneously hypertensive rats.", "tokenized_content": [2, 3835, 1022, 2626, 8028, 3, 2495, 1927, 7502, 24863, 1990, 2097, 17, 6124, 1930, 3835, 1022, 2626, 8028, 17, 2719, 15831, 1922, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_5378", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_5379", "content": "proteinuria [SEP] Effect of captopril on pre-existing and aminonucleoside-induced proteinuria in spontaneously hypertensive rats.", "tokenized_content": [2, 15831, 3, 2495, 1927, 7502, 24863, 1990, 2097, 17, 6124, 1930, 3835, 1022, 2626, 8028, 17, 2719, 15831, 1922, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_5379", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5380", "content": "hypertensive [SEP] isting and aminonucleoside-induced proteinuria in spontaneously hypertensive rats.", "tokenized_content": [2, 11706, 3, 1977, 2104, 1930, 3835, 1022, 2626, 8028, 17, 2719, 15831, 1922, 12753, 11706, 3615, 18, 3]}, "items": [{"id": "p_5380", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5381", "content": "Proteinuria [SEP] Proteinuria is a side effect of captopril treatment in hypertensive patient", "tokenized_content": [2, 15831, 3, 15831, 1977, 43, 4159, 2495, 1927, 7502, 24863, 2311, 1922, 11706, 2774, 3]}, "items": [{"id": "p_5381", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5382", "content": "captopril [SEP] Proteinuria is a side effect of captopril treatment in hypertensive patients. The possibility of reproduc", "tokenized_content": [2, 7502, 24863, 3, 15831, 1977, 43, 4159, 2495, 1927, 7502, 24863, 2311, 1922, 11706, 2132, 18, 1920, 5341, 1927, 5131, 3]}, "items": [{"id": "p_5382", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_5383", "content": "hypertensive [SEP] Proteinuria is a side effect of captopril treatment in hypertensive patients. The possibility of reproducing the same renal abnorma", "tokenized_content": [2, 11706, 3, 15831, 1977, 43, 4159, 2495, 1927, 7502, 24863, 2311, 1922, 11706, 2132, 18, 1920, 5341, 1927, 5131, 1941, 1920, 2841, 4604, 20109, 1019, 3]}, "items": [{"id": "p_5383", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5384", "content": "renal abnormality [SEP]  hypertensive patients. The possibility of reproducing the same renal abnormality with captopril was examined in SHR. Oral administration of capt", "tokenized_content": [2, 4604, 14311, 3, 11706, 2132, 18, 1920, 5341, 1927, 5131, 1941, 1920, 2841, 4604, 14311, 1956, 7502, 24863, 1982, 3572, 1922, 6606, 18, 4726, 4183, 1927, 7502, 3]}, "items": [{"id": "p_5384", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5385", "content": "proteinuria [SEP] ation of captopril at 100 mg/kg for 14 days failed to aggravate proteinuria pre-existing in SHR. Also, captopril treatment failed to potent", "tokenized_content": [2, 15831, 3, 2019, 2001, 1927, 7502, 24863, 2019, 2813, 2786, 19, 3621, 1958, 2607, 3000, 6617, 1942, 18206, 2010, 15831, 2097, 17, 6124, 1922, 6606, 18, 2222, 16, 7502, 24863, 3]}, "items": [{"id": "p_5385", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5386", "content": "puromycin aminonucleoside [SEP] ate or facilitate development of massive proteinuria invoked by puromycin aminonucleoside in SHR. Captopril had little or no demonstrable effects on seru", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 30280, 2014, 6628, 2740, 1927, 12944, 15831, 2269, 6729, 2007, 19750, 3835, 1022, 2626, 8028, 1922, 6606, 18, 7502, 24863, 2430, 5082, 2014, 2239, 3]}, "items": [{"id": "p_5386", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_5387", "content": "Captopril [SEP] assive proteinuria invoked by puromycin aminonucleoside in SHR. Captopril had little or no demonstrable effects on serum electrolyte conc", "tokenized_content": [2, 7502, 24863, 3, 2088, 2320, 15831, 2269, 6729, 2007, 19750, 3835, 1022, 2626, 8028, 1922, 6606, 18, 7502, 24863, 2430, 5082, 2014, 2239, 2714, 2115, 2564, 1990, 3256, 15428, 2499, 3]}, "items": [{"id": "p_5387", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_5388", "content": "sodium [SEP] ffects on serum electrolyte concentrations, excretion of urine, sodium and potassium, endogenous creatinine clearance, body weight, an", "tokenized_content": [2, 5227, 3, 10735, 2284, 1990, 3256, 15428, 3295, 16, 11093, 1927, 6960, 16, 5227, 1930, 9057, 16, 5355, 9374, 7802, 16, 3362, 3388, 16, 1925, 3]}, "items": [{"id": "p_5388", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_5389", "content": "potassium [SEP] erum electrolyte concentrations, excretion of urine, sodium and potassium, endogenous creatinine clearance, body weight, and food and wat", "tokenized_content": [2, 9057, 3, 25110, 1035, 15428, 3295, 16, 11093, 1927, 6960, 16, 5227, 1930, 9057, 16, 5355, 9374, 7802, 16, 3362, 3388, 16, 1930, 3959, 1930, 9071, 3]}, "items": [{"id": "p_5389", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_5390", "content": "creatinine [SEP] ntrations, excretion of urine, sodium and potassium, endogenous creatinine clearance, body weight, and food and water consumption. However", "tokenized_content": [2, 9374, 3, 20517, 2082, 16, 11093, 1927, 6960, 16, 5227, 1930, 9057, 16, 5355, 9374, 7802, 16, 3362, 3388, 16, 1930, 3959, 1930, 3224, 5434, 18, 2406, 3]}, "items": [{"id": "p_5390", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_5391", "content": "ketone [SEP] learance, body weight, and food and water consumption. However, ketone bodies were consistently present in urine and several lethaliti", "tokenized_content": [2, 21876, 3, 4237, 2152, 16, 3362, 3388, 16, 1930, 3959, 1930, 3224, 5434, 18, 2406, 16, 21876, 8322, 1985, 7522, 2481, 1922, 6960, 1930, 2980, 10470, 2078, 3]}, "items": [{"id": "p_5391", "content": "Ketones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21876, 1036, 3, 3]}]}
{"query": {"id": "q_5392", "content": "enflurane [SEP] Epileptogenic properties of enflurane and their clinical interpretation.", "tokenized_content": [2, 2066, 12676, 3, 28367, 3880, 3879, 1927, 2066, 12676, 1930, 2310, 2535, 6332, 18, 3]}, "items": [{"id": "p_5392", "content": "Enflurane [SEP] An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respi", "score": 1, "type": null, "tokenized_content": [2, 2066, 12676, 3, 1925, 8113, 4700, 14728, 16111, 1988, 5731, 4052, 15852, 1927, 8871, 6070, 1956, 5082, 3185, 1922, 7110, 2014, 2163, 1033, 3]}]}
{"query": {"id": "q_5393", "content": "enflurane [SEP] Three cases of EEG changes induced by single exposure to enflurane anesthesia are reported. In one patient, enflurane administered", "tokenized_content": [2, 2066, 12676, 3, 2559, 2919, 1927, 9052, 2840, 2719, 2007, 2957, 3395, 1942, 2066, 12676, 8871, 2032, 2568, 18, 1922, 2340, 2774, 16, 2066, 12676, 5254, 3]}, "items": [{"id": "p_5393", "content": "Enflurane [SEP] An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respi", "score": 1, "type": null, "tokenized_content": [2, 2066, 12676, 3, 1925, 8113, 4700, 14728, 16111, 1988, 5731, 4052, 15852, 1927, 8871, 6070, 1956, 5082, 3185, 1922, 7110, 2014, 2163, 1033, 3]}]}
{"query": {"id": "q_5394", "content": "seizures [SEP] during a donor nephrectomy resulted in unexpected partial motor seizures. Until the cause of the seizures was correctly identified, the ", "tokenized_content": [2, 10060, 3, 2409, 43, 6282, 22232, 4306, 1922, 9892, 5740, 4842, 10060, 18, 4801, 1920, 3936, 1927, 1920, 10060, 1982, 10329, 2899, 16, 1920, 3]}, "items": [{"id": "p_5394", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5395", "content": "Epileptic [SEP] l, complex and generalized seizures uncontrolled by medication. Epileptic foci delineated and activated by enflurane were surgically abla", "tokenized_content": [2, 16304, 3, 54, 16, 2796, 1930, 9612, 10060, 15734, 2007, 6093, 18, 16304, 10334, 21300, 1930, 4128, 2007, 2066, 12676, 1985, 16260, 10606, 1019, 3]}, "items": [{"id": "p_5395", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_5396", "content": "seizure [SEP] during a donor nephrectomy resulted in unexpected partial motor seizures. Until the cause of the seizures was correctly identified, the", "tokenized_content": [2, 11015, 3, 2409, 43, 6282, 22232, 4306, 1922, 9892, 5740, 4842, 10060, 18, 4801, 1920, 3936, 1927, 1920, 10060, 1982, 10329, 2899, 16, 1920, 3]}, "items": [{"id": "p_5396", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5397", "content": "epileptic [SEP] hand, enflurane may prove to be a safe fast acting activator of epileptic foci during corticography or depth electrode intraoperative rec", "tokenized_content": [2, 16304, 3, 3897, 16, 2066, 12676, 2278, 11948, 1942, 1998, 43, 7672, 5867, 8290, 9518, 1927, 16304, 10334, 2409, 8106, 3796, 2014, 6070, 7730, 12122, 2090, 3]}, "items": [{"id": "p_5397", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_5398", "content": "cerebral lesions [SEP] Reversible cerebral lesions associated with tiazofurin usage: MR demonstration.", "tokenized_content": [2, 6329, 4518, 3, 10743, 6329, 4518, 2458, 1956, 22093, 13642, 19073, 5572, 10070, 30, 2852, 13729, 18, 3]}, "items": [{"id": "p_5398", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_5399", "content": "tiazofurin [SEP] Reversible cerebral lesions associated with tiazofurin usage: MR demonstration.", "tokenized_content": [2, 22093, 13642, 19073, 5572, 3, 10743, 6329, 4518, 2458, 1956, 22093, 13642, 19073, 5572, 10070, 30, 2852, 13729, 18, 3]}, "items": [{"id": "p_5399", "content": "tiazofurin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22093, 13642, 19073, 5572, 3, 3]}]}
{"query": {"id": "q_5400", "content": "Tiazofurin [SEP] Tiazofurin is an experimental chemotherapeutic agent currently undergoing ", "tokenized_content": [2, 22093, 13642, 19073, 5572, 3, 22093, 13642, 19073, 5572, 1977, 1925, 3599, 14124, 5899, 5077, 7258, 3]}, "items": [{"id": "p_5400", "content": "tiazofurin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22093, 13642, 19073, 5572, 3, 3]}]}
{"query": {"id": "q_5401", "content": "cerebral abnormalities [SEP] esults with magnetic resonance (MR) in demonstrating reversible cerebral abnormalities concurrent with the use of this drug. The abnormalities on MR w", "tokenized_content": [2, 6329, 6754, 3, 2376, 17620, 1956, 5691, 6912, 12, 2852, 13, 1922, 7530, 10743, 6329, 6754, 10391, 1956, 1920, 2485, 1927, 2052, 2838, 18, 1920, 6754, 1990, 2852, 65, 3]}, "items": [{"id": "p_5401", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_5402", "content": "diazepam [SEP] Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery", "tokenized_content": [2, 26079, 3, 18394, 1927, 26079, 17, 2719, 28514, 2564, 2007, 3039, 3962, 17, 16877, 1025, 1922, 2132, 2256, 3782, 3]}, "items": [{"id": "p_5402", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_5403", "content": "Ro15-1788 [SEP] Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double", "tokenized_content": [2, 3039, 3962, 17, 16877, 1025, 3, 18394, 1927, 26079, 17, 2719, 28514, 2564, 2007, 3039, 3962, 17, 16877, 1025, 1922, 2132, 2256, 3782, 2441, 10781, 17282, 3367, 18, 43, 4825, 3]}, "items": [{"id": "p_5403", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_5404", "content": "Ro15-1788 [SEP] The aim of this study was to assess the efficacy of Ro15-1788 and a placebo in reversing diazepam-induced effects after surge", "tokenized_content": [2, 3039, 3962, 17, 16877, 1025, 3, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 2634, 1920, 4348, 1927, 3039, 3962, 17, 16877, 1025, 1930, 43, 5936, 1922, 26526, 26079, 17, 2719, 3]}, "items": [{"id": "p_5404", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_5405", "content": "diazepam [SEP]  to assess the efficacy of Ro15-1788 and a placebo in reversing diazepam-induced effects after surgery under epidural block, and to eval", "tokenized_content": [2, 26079, 3, 1942, 2634, 1920, 4348, 1927, 3039, 3962, 17, 16877, 1025, 1930, 43, 5936, 1922, 26526, 26079, 17, 2719, 2564, 2256, 3782, 2441, 17282, 3367, 16, 1930, 1942, 2180, 3]}, "items": [{"id": "p_5405", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_5406", "content": "amnesia [SEP] nt of mood rating, an objective test of performance, a test for amnesia, and vital signs were recorded for up to 300 min after administ", "tokenized_content": [2, 14701, 7156, 3, 5891, 1927, 9494, 7276, 16, 1925, 4470, 2648, 1927, 3604, 16, 43, 2648, 1958, 14701, 7156, 16, 1930, 8970, 6879, 1985, 4562, 1958, 2353, 1942, 5255, 2360, 3]}, "items": [{"id": "p_5406", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_5407", "content": "epinephrine [SEP] Enhanced stimulus-induced neurotransmitter overflow in epinephrine-induced hypertensive rats is not mediated by prejunctional beta", "tokenized_content": [2, 19280, 3, 4256, 5794, 17, 2719, 15223, 2338, 9893, 1922, 19280, 17, 2719, 11706, 3615, 1977, 2084, 3434, 2007, 2097, 12723, 2236, 1923, 4666, 3]}, "items": [{"id": "p_5407", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_5408", "content": "hypertensive [SEP] imulus-induced neurotransmitter overflow in epinephrine-induced hypertensive rats is not mediated by prejunctional beta-adrenoceptor activat", "tokenized_content": [2, 11706, 3, 2042, 9605, 17, 2719, 15223, 2338, 9893, 1922, 19280, 17, 2719, 11706, 3615, 1977, 2084, 3434, 2007, 2097, 12723, 2236, 1923, 4666, 17, 25090, 2196, 1926, 3]}, "items": [{"id": "p_5408", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5409", "content": "epinephrine [SEP] The present study examines the effect of 6-day epinephrine treatment (100 micrograms/kg per h, s.c.) on stimulus-induced (", "tokenized_content": [2, 19280, 3, 1920, 2481, 2161, 17910, 1920, 2495, 1927, 26, 17, 3007, 19280, 2311, 12, 2813, 13362, 19, 3621, 2079, 50, 16, 61, 18, 45, 18, 13, 1990, 5794, 17, 3]}, "items": [{"id": "p_5409", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_5410", "content": "catecholamine [SEP] perfused kidney of vehicle- and epinephrine-treated rats. Renal catecholamine stores and stimulus-induced overflow in the vehicle-treated gro", "tokenized_content": [2, 23483, 3, 13699, 5245, 1927, 6463, 17, 1930, 19280, 17, 2868, 3615, 18, 4604, 23483, 14846, 1930, 5794, 17, 2719, 2338, 9893, 1922, 1920, 6463, 17, 2868, 8947, 3]}, "items": [{"id": "p_5410", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_5411", "content": "norepinephrine [SEP] ulus-induced overflow in the vehicle-treated group consisted of norepinephrine only. However, epinephrine treatment resulted in the incorporat", "tokenized_content": [2, 16436, 3, 3570, 1957, 17, 2719, 2338, 9893, 1922, 1920, 6463, 17, 2868, 2210, 6994, 1927, 16436, 2444, 18, 2406, 16, 19280, 2311, 4306, 1922, 1920, 5109, 1926, 3]}, "items": [{"id": "p_5411", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_5412", "content": "Propranolol [SEP] was not affected by neuronal and extraneuronal uptake blockade. Propranolol had no effect on stimulus-induced overflow in either group. Phe", "tokenized_content": [2, 21395, 3, 1982, 2084, 4218, 2007, 5121, 1930, 8324, 2912, 28923, 5047, 9847, 18, 21395, 2430, 2239, 2495, 1990, 5794, 17, 2719, 2338, 9893, 1922, 3108, 2210, 18, 10422, 3]}, "items": [{"id": "p_5412", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_5413", "content": "Phentolamine [SEP] lol had no effect on stimulus-induced overflow in either group. Phentolamine increased stimulus-induced overflow in both groups although the", "tokenized_content": [2, 3037, 4575, 10082, 2053, 3, 3004, 1024, 2430, 2239, 2495, 1990, 5794, 17, 2719, 2338, 9893, 1922, 3108, 2210, 18, 3037, 4575, 10082, 2053, 2502, 5794, 17, 2719, 2338, 9893, 3]}, "items": [{"id": "p_5413", "content": "Phentolamine [SEP] A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromo", "score": 1, "type": null, "tokenized_content": [2, 3037, 4575, 10082, 2053, 3, 43, 6771, 25568, 4595, 17, 13672, 8151, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 5579, 1930, 11706, 14569, 15895, 2062, 16, 30004, 1037, 3]}]}
{"query": {"id": "q_5414", "content": "phentolamine [SEP] esponsible for this alteration. Furthermore, data obtained with phentolamine alone do not suggest alpha-adrenoceptor desensitization as the ", "tokenized_content": [2, 3037, 4575, 10082, 2053, 3, 21929, 2101, 2563, 1958, 2052, 10076, 18, 3677, 16, 2230, 2926, 1956, 3037, 4575, 10082, 2053, 4298, 2608, 2084, 3220, 4595, 17, 25090, 19008, 1966, 3]}, "items": [{"id": "p_5414", "content": "Phentolamine [SEP] A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromo", "score": 1, "type": null, "tokenized_content": [2, 3037, 4575, 10082, 2053, 3, 43, 6771, 25568, 4595, 17, 13672, 8151, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 5579, 1930, 11706, 14569, 15895, 2062, 16, 30004, 1037, 3]}]}
{"query": {"id": "q_5415", "content": "juvenile rheumatoid arthritis [SEP] Ocular manifestations of juvenile rheumatoid arthritis.", "tokenized_content": [2, 13010, 13053, 8884, 3, 10046, 10952, 1927, 13010, 13053, 8884, 18, 3]}, "items": [{"id": "p_5415", "content": "Arthritis, Juvenile [SEP] Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic ", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13010, 3, 8884, 1927, 3069, 16, 1956, 4727, 3119, 2641, 2739, 1927, 2632, 18, 1920, 4430, 13010, 13053, 8884, 12, 21886, 1019, 13, 1930, 13010, 13513, 3]}]}
{"query": {"id": "q_5416", "content": "juvenile rheumatoid arthritis [SEP] We followed 210 cases of juvenile rheumatoid arthritis closely for eleven years. Thirty-six of the 210 patients (17.2%", "tokenized_content": [2, 13010, 13053, 8884, 3, 2038, 3489, 12348, 2919, 1927, 13010, 13053, 8884, 6538, 1958, 14483, 2739, 18, 9942, 17, 3798, 1927, 1920, 12348, 2132, 12, 2752, 18, 22, 9, 3]}, "items": [{"id": "p_5416", "content": "Arthritis, Juvenile [SEP] Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic ", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13010, 3, 8884, 1927, 3069, 16, 1956, 4727, 3119, 2641, 2739, 1927, 2632, 18, 1920, 4430, 13010, 13053, 8884, 12, 21886, 1019, 13, 1930, 13010, 13513, 3]}]}
{"query": {"id": "q_5417", "content": "iridocyclitis [SEP]  eleven years. Thirty-six of the 210 patients (17.2%) developed iridocyclitis. Iridocyclitis was seen most frequently in young female patient", "tokenized_content": [2, 24768, 22389, 22170, 3678, 3, 14483, 2739, 18, 9942, 17, 3798, 1927, 1920, 12348, 2132, 12, 2752, 18, 22, 9, 13, 3530, 24768, 22389, 22170, 3678, 18, 24768, 22389, 22170, 3]}, "items": [{"id": "p_5417", "content": "Iridocyclitis [SEP] Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of", "score": 1, "type": null, "tokenized_content": [2, 24768, 22389, 22170, 3678, 3, 3939, 2014, 3724, 4531, 1927, 1920, 17187, 1930, 17542, 3362, 4378, 2007, 18787, 2209, 2460, 1920, 5477, 7329, 16, 2863, 18778, 1943, 1927, 3]}]}
{"query": {"id": "q_5418", "content": "Iridocyclitis [SEP] Thirty-six of the 210 patients (17.2%) developed iridocyclitis. Iridocyclitis was seen most frequently in young female patients (0 to 4 years", "tokenized_content": [2, 24768, 22389, 22170, 3678, 3, 9942, 17, 3798, 1927, 1920, 12348, 2132, 12, 2752, 18, 22, 9, 13, 3530, 24768, 22389, 22170, 3678, 18, 24768, 22389, 22170, 3678, 1982, 3945, 3]}, "items": [{"id": "p_5418", "content": "Iridocyclitis [SEP] Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of", "score": 1, "type": null, "tokenized_content": [2, 24768, 22389, 22170, 3678, 3, 3939, 2014, 3724, 4531, 1927, 1920, 17187, 1930, 17542, 3362, 4378, 2007, 18787, 2209, 2460, 1920, 5477, 7329, 16, 2863, 18778, 1943, 1927, 3]}]}
{"query": {"id": "q_5419", "content": "arthritis [SEP] We followed 210 cases of juvenile rheumatoid arthritis closely for eleven years. Thirty-six of the 210 patients (17.2%", "tokenized_content": [2, 8884, 3, 2038, 3489, 12348, 2919, 1927, 13010, 13053, 8884, 6538, 1958, 14483, 2739, 18, 9942, 17, 3798, 1927, 1920, 12348, 2132, 12, 2752, 18, 22, 9, 3]}, "items": [{"id": "p_5419", "content": "Arthritis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8884, 3, 3]}]}
{"query": {"id": "q_5420", "content": "uveitis [SEP] r form of the arthritis. However, 30% of the patients developed uveitis after 16 years of age. Although 61% of patients had a noncontri", "tokenized_content": [2, 22140, 3, 60, 2386, 1927, 1920, 8884, 18, 2406, 16, 2627, 9, 1927, 1920, 2132, 3530, 22140, 2256, 2641, 2739, 1927, 2632, 18, 2876, 5473, 9, 1927, 2132, 2430, 43, 3]}, "items": [{"id": "p_5420", "content": "Uveitis [SEP] Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera", "score": 1, "type": null, "tokenized_content": [2, 22140, 3, 4531, 1927, 3131, 2014, 2136, 1927, 1920, 18217, 1019, 16, 1920, 5576, 12, 4541, 13, 29171, 1927, 1920, 5723, 16, 1930, 5384, 5884, 1920, 2303, 29171, 1036, 12, 8266, 1019, 3]}]}
{"query": {"id": "q_5421", "content": "ocular pain [SEP] ad one or more identifiable signs or symptoms, such as red eye, ocular pain, decreased visual acuity, or photophobia, in order of decreasin", "tokenized_content": [2, 10046, 3594, 3, 2041, 2340, 2014, 2253, 19486, 6879, 2014, 3601, 16, 2427, 1966, 2312, 5723, 16, 10046, 3594, 16, 3261, 3737, 12320, 16, 2014, 10066, 2102, 18311, 16, 1922, 3]}, "items": [{"id": "p_5421", "content": "Eye Pain [SEP] A dull or sharp painful sensation associated with the outer or inner structures of the eyeball, having different causes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3594, 3, 43, 13247, 1024, 2014, 11707, 15806, 15826, 2458, 1956, 1920, 7642, 2014, 6671, 4061, 1927, 1920, 5723, 16344, 16, 4537, 2413, 5092, 18, 3]}]}
{"query": {"id": "q_5422", "content": "decreased visual acuity [SEP] e identifiable signs or symptoms, such as red eye, ocular pain, decreased visual acuity, or photophobia, in order of decreasing frequency. Even after e", "tokenized_content": [2, 3261, 3737, 12320, 3, 47, 19486, 6879, 2014, 3601, 16, 2427, 1966, 2312, 5723, 16, 10046, 3594, 16, 3261, 3737, 12320, 16, 2014, 10066, 2102, 18311, 16, 1922, 3238, 1927, 3]}, "items": [{"id": "p_5422", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_5423", "content": "photophobia [SEP] toms, such as red eye, ocular pain, decreased visual acuity, or photophobia, in order of decreasing frequency. Even after early detection a", "tokenized_content": [2, 10066, 2102, 18311, 3, 5970, 1036, 16, 2427, 1966, 2312, 5723, 16, 10046, 3594, 16, 3261, 3737, 12320, 16, 2014, 10066, 2102, 18311, 16, 1922, 3238, 1927, 7742, 3528, 18, 3]}, "items": [{"id": "p_5423", "content": "Photophobia [SEP] Abnormal sensitivity to light. This may occur as a manifestation of EYE DISEASES; MIGRAINE; SUBARACHNOID HEMORRHAGE; MENINGITIS;", "score": 1, "type": null, "tokenized_content": [2, 10066, 2102, 18311, 3, 4552, 3802, 1942, 3696, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 5723, 3902, 31, 13258, 31, 23795, 10489, 31, 16780, 31, 3]}]}
{"query": {"id": "q_5424", "content": "corticosteroids [SEP] ond to more than six months of intensive topical treatment with corticosteroids and mydriatics. Despite this, there was a dramatic decrease in ", "tokenized_content": [2, 14610, 3, 1990, 1007, 1942, 2253, 2254, 3798, 3221, 1927, 8100, 12259, 2311, 1956, 14610, 1930, 15388, 3027, 8574, 18, 4281, 2052, 16, 2276, 1982, 43, 10889, 3714, 1922, 3]}, "items": [{"id": "p_5424", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_5425", "content": "Cataract [SEP]  of blinding complications of uveitis cited in earlier studies. Cataract and band keratopathy occurred in only 22 and 13% of our group, ", "tokenized_content": [2, 14833, 3, 1927, 23691, 5021, 1927, 22140, 13301, 1922, 5556, 2351, 18, 14833, 1930, 5472, 16047, 6522, 4807, 1922, 2444, 2950, 1930, 2590, 9, 1927, 2342, 2210, 16, 3]}, "items": [{"id": "p_5425", "content": "Cataract [SEP] Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many ki", "score": 1, "type": null, "tokenized_content": [2, 14833, 3, 5740, 2014, 4080, 19888, 1999, 1990, 2014, 1922, 1920, 8540, 2014, 12174, 1927, 2340, 2014, 2321, 7127, 16, 25648, 9266, 2014, 7538, 19880, 18, 1920, 3086, 8191, 3]}]}
{"query": {"id": "q_5426", "content": "band keratopathy [SEP] complications of uveitis cited in earlier studies. Cataract and band keratopathy occurred in only 22 and 13% of our group, respectively. We used", "tokenized_content": [2, 5472, 16047, 6522, 3, 5021, 1927, 22140, 13301, 1922, 5556, 2351, 18, 14833, 1930, 5472, 16047, 6522, 4807, 1922, 2444, 2950, 1930, 2590, 9, 1927, 2342, 2210, 16, 2763, 18, 3]}, "items": [{"id": "p_5426", "content": "Corneal Dystrophy, Band-Shaped [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9990, 19321, 16, 5472, 17, 9132, 3, 3]}]}
{"query": {"id": "q_5427", "content": "chloroquine [SEP] occurred in only 22 and 13% of our group, respectively. We used chloroquine or hydroxychloroquine in 173 of 210 cases and found only one ca", "tokenized_content": [2, 20813, 3, 4807, 1922, 2444, 2950, 1930, 2590, 9, 1927, 2342, 2210, 16, 2763, 18, 2038, 2251, 20813, 2014, 8275, 11600, 1037, 15520, 1922, 15853, 1927, 12348, 2919, 1930, 2435, 3]}, "items": [{"id": "p_5427", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_5428", "content": "hydroxychloroquine [SEP] y 22 and 13% of our group, respectively. We used chloroquine or hydroxychloroquine in 173 of 210 cases and found only one case of chorioretinopath", "tokenized_content": [2, 8275, 11600, 1037, 15520, 3, 67, 2950, 1930, 2590, 9, 1927, 2342, 2210, 16, 2763, 18, 2038, 2251, 20813, 2014, 8275, 11600, 1037, 15520, 1922, 15853, 1927, 12348, 2919, 1930, 3]}, "items": [{"id": "p_5428", "content": "Hydroxychloroquine [SEP] A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate i", "score": 1, "type": null, "tokenized_content": [2, 8275, 11600, 1037, 15520, 3, 43, 14124, 5899, 1988, 8016, 3316, 25940, 27932, 1935, 4952, 1927, 29535, 9687, 18, 8275, 11600, 1037, 15520, 5107, 1942, 18410, 51, 3]}]}
{"query": {"id": "q_5429", "content": "chorioretinopathy [SEP] droxychloroquine in 173 of 210 cases and found only one case of chorioretinopathy attributable to these drugs. Systemically administered corticos", "tokenized_content": [2, 25952, 28771, 6522, 3, 8442, 10465, 11600, 1037, 15520, 1922, 15853, 1927, 12348, 2919, 1930, 2435, 2444, 2340, 3087, 1927, 25952, 28771, 6522, 11081, 1942, 2144, 4195, 18, 22791, 5254, 3]}, "items": [{"id": "p_5429", "content": "Retinal Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6943, 3902, 3, 3]}]}
{"query": {"id": "q_5430", "content": "cataracts [SEP]  75 of 210 cases; a significant number of posterior subcapsular cataracts was found. Typical keratoconjunctivitis sicca developed in thre", "tokenized_content": [2, 14833, 1036, 3, 4089, 1927, 12348, 2919, 31, 43, 2228, 2529, 1927, 5545, 5736, 3251, 2168, 14833, 1036, 1982, 2435, 18, 5939, 16047, 10332, 12723, 2341, 2068, 3678, 16022, 3375, 3]}, "items": [{"id": "p_5430", "content": "Cataract [SEP] Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many ki", "score": 1, "type": null, "tokenized_content": [2, 14833, 3, 5740, 2014, 4080, 19888, 1999, 1990, 2014, 1922, 1920, 8540, 2014, 12174, 1927, 2340, 2014, 2321, 7127, 16, 25648, 9266, 2014, 7538, 19880, 18, 1920, 3086, 8191, 3]}]}
{"query": {"id": "q_5431", "content": "keratoconjunctivitis [SEP] nt number of posterior subcapsular cataracts was found. Typical keratoconjunctivitis sicca developed in three of the uveitis cases. This association", "tokenized_content": [2, 16047, 10332, 12723, 2341, 2068, 3678, 3, 5891, 2529, 1927, 5545, 5736, 3251, 2168, 14833, 1036, 1982, 2435, 18, 5939, 16047, 10332, 12723, 2341, 2068, 3678, 16022, 3375, 3530, 1922, 3]}, "items": [{"id": "p_5431", "content": "Keratoconjunctivitis [SEP] Simultaneous inflammation of the cornea and conjunctiva.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16047, 10332, 12723, 2341, 2068, 3678, 3, 5710, 4531, 1927, 1920, 16678, 1930, 16911, 1019, 18, 3]}]}
{"query": {"id": "q_5432", "content": "glaucoma [SEP] viously. Surgical treatment of cataracts, band keratopathy, and glaucoma achieved uniformly discouraging results.", "tokenized_content": [2, 12106, 3, 3070, 8232, 18, 4548, 2311, 1927, 14833, 1036, 16, 5472, 16047, 6522, 16, 1930, 12106, 5032, 14474, 26567, 3196, 2274, 18, 3]}, "items": [{"id": "p_5432", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_5433", "content": "Water intoxication [SEP] Water intoxication associated with oxytocin administration during saline-induced a", "tokenized_content": [2, 3224, 20965, 3, 3224, 20965, 2458, 1956, 17775, 4183, 2409, 5977, 17, 2719, 43, 3]}, "items": [{"id": "p_5433", "content": "Water Intoxication [SEP] A condition resulting from the excessive retention of water with sodium depletion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3224, 20965, 3, 43, 2625, 3864, 2037, 1920, 9122, 7521, 1927, 3224, 1956, 5227, 6882, 18, 3]}]}
{"query": {"id": "q_5434", "content": "oxytocin [SEP] Water intoxication associated with oxytocin administration during saline-induced abortion.", "tokenized_content": [2, 17775, 3, 3224, 20965, 2458, 1956, 17775, 4183, 2409, 5977, 17, 2719, 15660, 18, 3]}, "items": [{"id": "p_5434", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_5435", "content": "abortion [SEP] n associated with oxytocin administration during saline-induced abortion.", "tokenized_content": [2, 15660, 3, 56, 2458, 1956, 17775, 4183, 2409, 5977, 17, 2719, 15660, 18, 3]}, "items": [{"id": "p_5435", "content": "Abortion, Septic [SEP] Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characte", "score": 1, "type": null, "tokenized_content": [2, 15660, 16, 13927, 3, 2967, 2601, 1927, 15660, 16, 2719, 2014, 6242, 16, 1988, 1977, 2458, 1956, 2909, 1927, 1920, 16297, 1930, 2496, 7958, 2662, 18, 2176, 1977, 2618, 2131, 1021, 3]}]}
{"query": {"id": "q_5436", "content": "water intoxication [SEP] Four cases of water intoxication in connection with oxytocin administration during saline-induce", "tokenized_content": [2, 3224, 20965, 3, 3006, 2919, 1927, 3224, 20965, 1922, 10393, 1956, 17775, 4183, 2409, 5977, 17, 4769, 3]}, "items": [{"id": "p_5436", "content": "Water Intoxication [SEP] A condition resulting from the excessive retention of water with sodium depletion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3224, 20965, 3, 43, 2625, 3864, 2037, 1920, 9122, 7521, 1927, 3224, 1956, 5227, 6882, 18, 3]}]}
{"query": {"id": "q_5437", "content": "oxytocin [SEP] Four cases of water intoxication in connection with oxytocin administration during saline-induced abortions are described. T", "tokenized_content": [2, 17775, 3, 3006, 2919, 1927, 3224, 20965, 1922, 10393, 1956, 17775, 4183, 2409, 5977, 17, 2719, 30379, 2032, 2910, 18, 62, 3]}, "items": [{"id": "p_5437", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_5438", "content": "abortions [SEP] n connection with oxytocin administration during saline-induced abortions are described. The mechanism of water intoxication is discussed", "tokenized_content": [2, 30379, 3, 56, 10393, 1956, 17775, 4183, 2409, 5977, 17, 2719, 30379, 2032, 2910, 18, 1920, 2856, 1927, 3224, 20965, 1977, 5601, 3]}, "items": [{"id": "p_5438", "content": "Abortion, Septic [SEP] Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characte", "score": 1, "type": null, "tokenized_content": [2, 15660, 16, 13927, 3, 2967, 2601, 1927, 15660, 16, 2719, 2014, 6242, 16, 1988, 1977, 2458, 1956, 2909, 1927, 1920, 16297, 1930, 2496, 7958, 2662, 18, 2176, 1977, 2618, 2131, 1021, 3]}]}
{"query": {"id": "q_5439", "content": "Oxytocin [SEP] sm of water intoxication is discussed in regard to these cases. Oxytocin administration during midtrimester-induced abortions is advocat", "tokenized_content": [2, 17775, 3, 2426, 1927, 3224, 20965, 1977, 5601, 1922, 4623, 1942, 2144, 2919, 18, 17775, 4183, 2409, 3953, 1997, 11593, 2156, 1915, 17, 2719, 30379, 1977, 15767, 1926, 3]}, "items": [{"id": "p_5439", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_5440", "content": "asthenia [SEP] tch the diuresis and report such early signs of the syndrome as asthenia, muscular irritability, or headaches. The oxytocin should be gi", "tokenized_content": [2, 6187, 8572, 3, 5283, 1023, 1920, 2137, 27718, 1930, 3809, 2427, 3120, 6879, 1927, 1920, 4741, 1966, 6187, 8572, 16, 12330, 29534, 16, 2014, 24339, 18, 1920, 17775, 3066, 1998, 3]}, "items": [{"id": "p_5440", "content": "Asthenia [SEP] Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6187, 8572, 3, 2535, 2105, 2014, 3226, 16687, 1966, 26068, 1999, 16, 2014, 3630, 2014, 3257, 1927, 4568, 1930, 3844, 18, 3]}]}
{"query": {"id": "q_5441", "content": "irritability [SEP] d report such early signs of the syndrome as asthenia, muscular irritability, or headaches. The oxytocin should be given only in Ringers lac", "tokenized_content": [2, 29534, 3, 46, 3809, 2427, 3120, 6879, 1927, 1920, 4741, 1966, 6187, 8572, 16, 12330, 29534, 16, 2014, 24339, 18, 1920, 17775, 3066, 1998, 3258, 2444, 1922, 26339, 1036, 7511, 3]}, "items": [{"id": "p_5441", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_5442", "content": "headaches [SEP] ly signs of the syndrome as asthenia, muscular irritability, or headaches. The oxytocin should be given only in Ringers lactate or, alter", "tokenized_content": [2, 24339, 3, 7518, 6879, 1927, 1920, 4741, 1966, 6187, 8572, 16, 12330, 29534, 16, 2014, 24339, 18, 1920, 17775, 3066, 1998, 3258, 2444, 1922, 26339, 1036, 9456, 2014, 16, 4238, 3]}, "items": [{"id": "p_5442", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_5443", "content": "lactate [SEP] ity, or headaches. The oxytocin should be given only in Ringers lactate or, alternately, in Ringers lactate and a 5 per cent dextrose a", "tokenized_content": [2, 9456, 3, 2176, 1012, 16, 2014, 24339, 18, 1920, 17775, 3066, 1998, 3258, 2444, 1922, 26339, 1036, 9456, 2014, 16, 14263, 1954, 16, 1922, 26339, 1036, 9456, 1930, 43, 25, 3]}, "items": [{"id": "p_5443", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_5444", "content": "dextrose [SEP] rs lactate or, alternately, in Ringers lactate and a 5 per cent dextrose and water solutions. The urinary output should be monitored and", "tokenized_content": [2, 22444, 3, 4366, 9456, 2014, 16, 14263, 1954, 16, 1922, 26339, 1036, 9456, 1930, 43, 25, 2079, 3208, 22444, 1930, 3224, 6551, 18, 1920, 7075, 6647, 3066, 1998, 7027, 1930, 3]}, "items": [{"id": "p_5444", "content": "Glucose [SEP] A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in i", "score": 1, "type": null, "tokenized_content": [2, 3817, 3, 43, 3065, 4585, 1927, 3844, 1958, 5818, 7373, 18, 2176, 1977, 10414, 6966, 1930, 1977, 2435, 1922, 12953, 1930, 2303, 7516, 1927, 4793, 1922, 51, 3]}]}