Graves' disease [SEP] PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.

Graves Disease [SEP] A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies again


purpura [SEP] Palpable purpura is a concerning clinical finding in pediatric patients and can

Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si


vasculitis [SEP] infectious and autoimmune processes. A rare cause, drug-induced vasculitis, may result from the production of antineutrophil cytoplasmic a

Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.


Turner syndrome [SEP] dies (ANCAs) in response to a medication. We report a girl with Turner syndrome and Graves' disease who presented with palpable purpuric lesion

Turner Syndrome [SEP] A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients genera


Graves' disease [SEP] onse to a medication. We report a girl with Turner syndrome and Graves' disease who presented with palpable purpuric lesions. The diagnosis of


purpuric lesions [SEP] Turner syndrome and Graves' disease who presented with palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis


propylthiouracil [SEP]  who presented with palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis was made by observation of consiste

Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro


PTU [SEP] h palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis was made by observation of consistent cl


hyperthyroidism [SEP] following withdrawal of PTU. Subsequent treatment of persistent hyperthyroidism with radioablation did not result in an exacerbation of the vas

Hyperthyroidism [SEP] Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.


Succinylcholine [SEP] Succinylcholine-induced masseter muscle rigidity during bronchoscopic removal o

Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan


masseter muscle rigidity [SEP] Succinylcholine-induced masseter muscle rigidity during bronchoscopic removal of a tracheal foreign body.

Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc


Masseter muscle rigidity [SEP] Masseter muscle rigidity during general anesthesia is considered an early warning sign o


malignant hyperthermia [SEP] ia is considered an early warning sign of a possible episode of malignant hyperthermia. The decision whether to continue or discontinue the procedure

Malignant Hyperthermia [SEP] Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.


masseter muscle rigidity [SEP] procedure depends on the urgency of the surgery and severity of masseter muscle rigidity. Here, we describe a case of severe masseter muscle rigidity (j


jaw of steel [SEP] y. Here, we describe a case of severe masseter muscle rigidity (jaw of steel) after succinylcholine (Sch) administration during general anes


succinylcholine [SEP]  a case of severe masseter muscle rigidity (jaw of steel) after succinylcholine (Sch) administration during general anesthetic management for r


Sch [SEP]  masseter muscle rigidity (jaw of steel) after succinylcholine (Sch) administration during general anesthetic management for rigid


propofol [SEP] acheal foreign body. Anesthesia was continued uneventfully with propofol infusion while all facilities were available to detect and trea

Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor


neurological dysfunction [SEP] Minor neurological dysfunction, cognitive development, and somatic development at the age of 3

Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph


dexamethasone [SEP] pment, and somatic development at the age of 3 to 7 years after dexamethasone treatment in very-low birth-weight infants.

Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.


neurological dysfunction [SEP] The objective of this study was to assess minor neurological dysfunction, cognitive development, and somatic development after dexametha


dexamethasone [SEP] sfunction, cognitive development, and somatic development after dexamethasone therapy in very-low-birthweight infants. Thirty-three children


Dexamethasone [SEP] ethasone treatment. Data were assessed at the age of 3-7 years. Dexamethasone was started between the 7th and the 28th day of life over 7 day


asphyxia [SEP] ys with a total dose of 2.35 mg/kg/day. Exclusion criteria were asphyxia, malformations, major surgical interventions, small for gestati

Asphyxia [SEP] A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.


malformations [SEP] total dose of 2.35 mg/kg/day. Exclusion criteria were asphyxia, malformations, major surgical interventions, small for gestational age, intra

Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in


haemorrhage [SEP] ical interventions, small for gestational age, intraventricular haemorrhage grades III and IV, periventricular leukomalacia, and severe psy

Hemorrhage [SEP] Bleeding or escape of blood from a vessel.


periventricular leukomalacia [SEP] estational age, intraventricular haemorrhage grades III and IV, periventricular leukomalacia, and severe psychomotor retardation. Each child was examined by

Leukomalacia, Periventricular [SEP] Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The c


psychomotor retardation [SEP] age grades III and IV, periventricular leukomalacia, and severe psychomotor retardation. Each child was examined by a neuropediatrician for minor neuro

Psychomotor Disorders [SEP] Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.


neurological dysfunctions [SEP] ation. Each child was examined by a neuropediatrician for minor neurological dysfunctions and tested by a psychologist for cognitive development with a K


levodopa [SEP] Force overflow and levodopa-induced dyskinesias in Parkinson's disease.

Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b


dyskinesias [SEP] Force overflow and levodopa-induced dyskinesias in Parkinson's disease.

Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or


Parkinson's disease [SEP] Force overflow and levodopa-induced dyskinesias in Parkinson's disease.

Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency


Parkinson's disease [SEP] We assessed force coordination of the hand in Parkinson's disease and its relationship to motor complications of levodopa therapy


levodopa [SEP] kinson's disease and its relationship to motor complications of levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We


dyskinesias [SEP] lications of levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We studied two groups of Parkinson's disease patients wi


LID [SEP] levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We studied two groups of Parkinson's disease patients with (P


Parkinson's Disease [SEP] nd age-matched healthy controls. The motor score of the Unified Parkinson's Disease Rating Scale, a dyskinesia score and force in a grip-lift parad


dyskinesia [SEP] lications of levodopa therapy, particularly to levodopa-induced dyskinesias (LID). We studied two groups of Parkinson's disease patients w


ventricular septal defect [SEP] Postinfarction ventricular septal defect associated with long-term steroid therapy.

Ventricular Septal Rupture [SEP] Laceration or tearing of the VENTRICULAR SEPTUM, usually caused by MYOCARDIAL INFARCTION.


steroid [SEP] tinfarction ventricular septal defect associated with long-term steroid therapy.

Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso


ventricular septal rupture [SEP] Two cases of postinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the


steroid [SEP] tinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the favourable outcome in both cases


septal rupture [SEP] Two cases of postinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the


Angioedema [SEP] Angioedema associated with droperidol administration.

Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i


droperidol [SEP] Angioedema associated with droperidol administration.

Droperidol [SEP] A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such


Angioedema [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a w


angioneurotic edema [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a well-demarcated, localized edema inv


Quincke's disease [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a well-demarcated, localized edema involving the subcutaneo


edema [SEP] Angioedema, also known as angioneurotic edema or Quincke's disease, is a w

Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.


upper-airway obstruction [SEP] calized edema involving the subcutaneous tissues that may cause upper-airway obstruction. We report the case of a previously healthy 19-year-old man wit

Airway Obstruction [SEP] Any hindrance to the passage of air into and out of the lungs.


drug allergies [SEP]  the case of a previously healthy 19-year-old man with no known drug allergies in whom angioedema with significant tongue swelling and protrus

Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.


angioedema [SEP] ly healthy 19-year-old man with no known drug allergies in whom angioedema with significant tongue swelling and protrusion developed withi


tongue swelling [SEP] ith no known drug allergies in whom angioedema with significant tongue swelling and protrusion developed within 10 minutes of the administratio

Tongue Diseases [SEP]


swelling [SEP] known drug allergies in whom angioedema with significant tongue swelling and protrusion developed within 10 minutes of the administratio


droperidol [SEP]  within 10 minutes of the administration of a single IV dose of droperidol.


Clarithromycin [SEP] Clarithromycin-associated visual hallucinations in a patient with chronic rena

Clarithromycin [SEP] A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibi


visual hallucinations [SEP] Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulator

Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.


chronic renal failure [SEP] arithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis.

Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l


Visual hallucinations [SEP] Visual hallucinations are a rare event in chronic renal failure and not related to ur


chronic renal failure [SEP] Visual hallucinations are a rare event in chronic renal failure and not related to uremia per se. Unreported in the literature


uremia [SEP] ns are a rare event in chronic renal failure and not related to uremia per se. Unreported in the literature is visual hallucinations o

Uremia [SEP] A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the resul


visual hallucinations [SEP] d not related to uremia per se. Unreported in the literature is visual hallucinations occurring in association with the new macrolide antibiotic, cla


macrolide [SEP]  is visual hallucinations occurring in association with the new macrolide antibiotic, clarithromycin. We describe such a case in a patien

Macrolides [SEP] A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typ


clarithromycin [SEP] ons occurring in association with the new macrolide antibiotic, clarithromycin. We describe such a case in a patient with end-stage renal dise


end-stage renal disease [SEP] otic, clarithromycin. We describe such a case in a patient with end-stage renal disease (ESRD) maintained on continuous ambulatory peritoneal dialysis


ESRD [SEP] describe such a case in a patient with end-stage renal disease (ESRD) maintained on continuous ambulatory peritoneal dialysis (CAPD)


aluminum [SEP] nal failure in a functionally anephric patient, with underlying aluminum intoxication, may have facilitated the appearance of this neuro

Aluminum [SEP] A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.


neurotoxic [SEP] minum intoxication, may have facilitated the appearance of this neurotoxic side effect. It is important to understand the pharmacokinetics

Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method


renal toxicity [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.

Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.


doxorubicin [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.

Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.


adriamycin [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.


cyanoacrylate [SEP] Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.

Cyanoacrylates [SEP] A group of compounds having the general formula CH2=C(CN)-COOR; it polymerizes on contact with moisture; used as tissue adhesive


doxorubicin [SEP] Acute doxorubicin-loaded nanoparticle (DXNP) renal toxicity was explored in both


renal toxicity [SEP] Acute doxorubicin-loaded nanoparticle (DXNP) renal toxicity was explored in both normal rats and rats with experimental glo


glomerulonephritis [SEP] ity was explored in both normal rats and rats with experimental glomerulonephritis. In normal rats, 2/6 rats given free doxorubicin (DX) (5 mg/kg)

Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti


DX [SEP] Acute doxorubicin-loaded nanoparticle (DXNP) renal toxicity was explored in both normal rats and rats wit


proteinuria [SEP] rats having received free NP or DXNP survived. A 3 times higher proteinuria appeared in animals treated with DXNP than in those treated wit

Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.


Proteinuria [SEP]  animals treated by DXNP, NP, or untreated, which all survived. Proteinuria appeared in all series, but was 2-5 times more intense (p > 0.0


nephrosis [SEP] renal toxicity of the former. Both effects (better survival and nephrosis) are most probably related to an enhanced capture of DXNP by ce

Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon


Etoposide [SEP] Etoposide-related myocardial infarction.

Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co


myocardial infarction [SEP] Etoposide-related myocardial infarction.

Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).


myocardial infarction [SEP] The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man w


etoposide [SEP] myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease. Poss


coronary heart disease [SEP] therapy containing etoposide, in a man with no risk factors for coronary heart disease. Possible causal mechanisms are discussed.

Coronary Disease [SEP] An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow


sexual dysfunction [SEP] Subjective assessment of sexual dysfunction of patients on long-term administration of digoxin.

Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis


digoxin [SEP] f sexual dysfunction of patients on long-term administration of digoxin.

Digoxin [SEP] A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin


digoxin [SEP] Various data suggest that male patients who have received digoxin on a longterm basis have increased levels of serum estrogen and


estrogen [SEP] ived digoxin on a longterm basis have increased levels of serum estrogen and decreased levels of plasma testosterone and luteinizing hor

Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr


testosterone [SEP] creased levels of serum estrogen and decreased levels of plasma testosterone and luteinizing hormone (LH). This study was undertaken to inve

Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN


estradiol [SEP]  sexual behavior, and the effect of digoxin on plasma levels of estradiol, testosterone, and LH. The patients of the study and control gr

Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet


rheumatic heart disease [SEP] acity and age (25-40 years) and were randomly selected from the rheumatic heart disease patients. A subjective assessment of sexual behavior in the stu

Rheumatic Heart Disease [SEP] Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any p


decrease in sexual desire [SEP] to evaluate the changes in sexual behavior showed a significant decrease in sexual desire, sexual excitement phase (erection), and frequency of sexual re


aplastic anemia [SEP] Fatal aplastic anemia due to indomethacin--lymphocyte transformation tests in vitro.

Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.


indomethacin [SEP] Fatal aplastic anemia due to indomethacin--lymphocyte transformation tests in vitro.

Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla


indomethacin [SEP] Although indomethacin has been implicated as a possible cause of aplastic anemia on t


aplastic anemia [SEP] lthough indomethacin has been implicated as a possible cause of aplastic anemia on the basis of a few clinical observations, its role has not b


allopurinol [SEP] fatal aplastic anemia is described in which no drugs other than allopurinol and indomethacin were given. Indomethacin was first given four

Allopurinol [SEP] A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.


Indomethacin [SEP] ch no drugs other than allopurinol and indomethacin were given. Indomethacin was first given four weeks prior to the onset of symptoms. A po


nephrotic syndrome [SEP] a and urinary lipids and lipoproteins during the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside.

Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in


puromycin aminonucleoside [SEP] ing the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside.

Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl


nephrotic syndrome [SEP] certain whether the alterations of plasma lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephrotic synd


puromycin aminonucleoside [SEP] s of plasma lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephrotic syndrome per se, or, at least in part, to


aminonucleoside [SEP] a lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephrotic syndrome per se, or, at least in part, to


albuminuria [SEP] the subsequent development of nephrotic syndrome. Since massive albuminuria occurred after 6 days of treatment, the time-course study was d

Albuminuria [SEP] The presence of albumin in the urine, an indicator of KIDNEY DISEASES.


nephrotic [SEP] certain whether the alterations of plasma lipoproteins found in nephrotic syndrome induced by puromycin aminonucleoside were due to nephr


fatty acids [SEP] ic stage (day 6-11). In pre-nephrotic stage the plasma level of fatty acids, triacylglycerol and VLDL decreased while that of phospholipid,

Fatty Acids [SEP] Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and


triacylglycerol [SEP]  6-11). In pre-nephrotic stage the plasma level of fatty acids, triacylglycerol and VLDL decreased while that of phospholipid, cholesteryl este

Triglycerides [SEP]


cholesteryl esters [SEP]  triacylglycerol and VLDL decreased while that of phospholipid, cholesteryl esters and HDL remained constant. Plasma apolipoprotein A-I tended to

Cholesterol Esters [SEP] Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholest


acute hepatic necrosis [SEP] Circulating lysosomal enzymes and acute hepatic necrosis.

Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H


fulminant hepatic failure [SEP] nd acid phosphatase were measured in the serum of patients with fulminant hepatic failure. Acid protease (cathepsin D) activity was increased about tenfo


paracetamol [SEP]  fourfold in those who survived fulminant hepatic failure after paracetamol overdose, whereas activities were increased equally in patients

Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but


overdose [SEP]  those who survived fulminant hepatic failure after paracetamol overdose, whereas activities were increased equally in patients with ful

Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.


viral hepatitis [SEP] eased equally in patients with fulminant hepatic failure due to viral hepatitis whether or not they survived. A correlation was found between s

Hepatitis, Viral, Human [SEP] INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis wi


aspartate [SEP] hepsin D activity was sustained over several days compared with aspartate aminotransferase, which showed a sharp early peak and then a fa

Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca


tolazamide [SEP] Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy.

Tolazamide [SEP] A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.


Wernicke's encephalopathy [SEP] Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy.

Wernicke Encephalopathy [SEP] An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or con


thiamine [SEP] We studied a thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic

Thiamine [SEP] 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.


diabetic [SEP] thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated wi

Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.


Wernicke's encephalopathy [SEP] sketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this pat


tolazamide [SEP] tient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this patient also had transketolase a


thiamine pyrophosphate [SEP] if this patient also had transketolase abnormality [high Km for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsak

Thiamine Pyrophosphate [SEP] The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMP


TPP [SEP]  transketolase abnormality [high Km for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff s


Wernicke-Korsakoff syndrome [SEP] e pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff syndrome. In addition to this patient, we also studied this enzyme from

Korsakoff Syndrome [SEP] An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is


myocardial ischemia [SEP] Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischem

Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may


epinephrine [SEP] Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischemia.

Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes


ischemia [SEP] Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischem

Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,


epinephrine [SEP] The role of epinephrine in eliciting myocardial ischemia was examined in patients with


myocardial ischemia [SEP] The role of epinephrine in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objectiv


coronary artery disease [SEP]  in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objective signs of ischemia and factors increasing myocardial

Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot


ischemia [SEP] The role of epinephrine in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objectiv


oxygen [SEP] . Objective signs of ischemia and factors increasing myocardial oxygen consumption were compared during epinephrine infusion and supin

Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear


depression [SEP] xercise produced myocardial ischemia as evidenced by ST segment depression and angina. However, the mechanisms of myocardial ischemia indu

Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur


angina [SEP] d myocardial ischemia as evidenced by ST segment depression and angina. However, the mechanisms of myocardial ischemia induced by epin

Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is


contralateral rotation [SEP] Transient contralateral rotation following unilateral substantia nigra lesion reflects susceptib

Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati


amphetamine [SEP] cts susceptibility of the nigrostriatal system to exhaustion by amphetamine.

Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin


6-OHDA [SEP] Following unilateral 6-OHDA induced SN lesion, a transient period of contralateral rotation

Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th


contralateral rotation [SEP] wing unilateral 6-OHDA induced SN lesion, a transient period of contralateral rotation has been reported to precede the predominant ipsilateral circli


ipsilateral circling [SEP] ralateral rotation has been reported to precede the predominant ipsilateral circling. In order to clarify the nature of this initial contralateral r


amphetamine [SEP]  effect of the duration of recovery period after the lesion, on amphetamine-induced rotational behavior. Three days post lesion, most rats


rotational behavior [SEP] ion of recovery period after the lesion, on amphetamine-induced rotational behavior. Three days post lesion, most rats circled predominantly contra


rotation [SEP] l 6-OHDA induced SN lesion, a transient period of contralateral rotation has been reported to precede the predominant ipsilateral circli


lithium [SEP] Thyroid function and urine-concentrating ability during lithium treatment.

Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of


nephrogenic diabetes insipidus [SEP]  cyclase inhibition may be important in the development of both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum

Diabetes Insipidus, Nephrogenic [SEP] A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to re


hypothyroidism [SEP] t in the development of both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum thyroxine and urine

Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL


lithium [SEP] f both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum thyroxine and urine-concentrating


thyroxine [SEP]  and hypothyroidism during lithium treatment. We measured serum thyroxine and urine-concentrating ability (Umax) in response to desmopres

Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an


Hypothyroidism [SEP] ponse to desmopressin (DDAVP) in 85 patients receiving lithium. Hypothyroidism developed in eight patients while they were taking lithium. Imp


hypothyroid [SEP] t in the development of both nephrogenic diabetes insipidus and hypothyroidism during lithium treatment. We measured serum thyroxine and ur


azidothymidine [SEP] nsitivity of erythroid progenitor colonies to erythropoietin in azidothymidine treated immunodeficient mice.

Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific


immunodeficient [SEP] progenitor colonies to erythropoietin in azidothymidine treated immunodeficient mice.

Immune Deficiency Disease [SEP]


anaemia [SEP] The anaemia induced by 3'-azido-3'dideoxythymidine (AZT) is poorly understo

Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.


3'-azido-3'dideoxythymidine [SEP] The anaemia induced by 3'-azido-3'dideoxythymidine (AZT) is poorly understood. We have used a murine model of AIDS


AZT [SEP] The anaemia induced by 3'-azido-3'dideoxythymidine (AZT) is poorly understood. We have used a murine model of AIDS, inf


AIDS [SEP] dine (AZT) is poorly understood. We have used a murine model of AIDS, infection of female C57BL/6 mice with LP-BM5 murine leukaemia

Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly


infection [SEP] AZT) is poorly understood. We have used a murine model of AIDS, infection of female C57BL/6 mice with LP-BM5 murine leukaemia (MuLV) viru

Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.


leukaemia [SEP] el of AIDS, infection of female C57BL/6 mice with LP-BM5 murine leukaemia (MuLV) virus, to determine if AZT-induced anaemia is due, in pa

Leukemia [SEP] A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukoc


phenylhydrazine [SEP] propriate for the degree of anaemia observed when compared with phenylhydrazine (PHZ) treated mice. The numbers of BFU-e and the percentage of

phenylhydrazine [SEP]


PHZ [SEP]  degree of anaemia observed when compared with phenylhydrazine (PHZ) treated mice. The numbers of BFU-e and the percentage of bone

phenylhydrazine [SEP]


reticulocytosis [SEP]  and PHZ treated mice with similar degrees of anaemia. However, reticulocytosis was inappropriate for the degree of anaemia observed in AZT tre

Reticulocytosis [SEP] An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE product


adriamycin [SEP] Detection of abnormal cardiac adrenergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.

Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.


cardiomyopathy [SEP] normal cardiac adrenergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.

Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi


iodine-125-metaiodobenzylguanidine [SEP] ergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.

3-Iodobenzylguanidine [SEP] A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled for


Radiolabeled metaiodobenzylguanidine [SEP] Radiolabeled metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of


MIBG [SEP] Radiolabeled metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of adren


norepinephrine [SEP] Radiolabeled metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of adrenergic neuron integrity and fun

Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor


NE [SEP] ed metaiodobenzylguanidine (MIBG), an analog of norepinephrine (NE), serves as an index of adrenergic neuron integrity and functio


adriamycin [SEP]  adrenergic neuron integrity and function. Using a rat model of adriamycin-induced cardiomyopathy, we tested the hypothesis that abnormal


cardiomyopathy [SEP] integrity and function. Using a rat model of adriamycin-induced cardiomyopathy, we tested the hypothesis that abnormal cardiac adrenergic neur


vacuolar degeneration of myocardial cells [SEP] ed dose-dependently in adriamycin cardiomyopathy. The degree of vacuolar degeneration of myocardial cells was analyzed in relation to the duration of adriamycin treatmen

Vacuolar myopathy [SEP]


myocardial impairment [SEP] ed cardiac adrenergic neuron activity in the presence of slight myocardial impairment (scattered or focal vacuolar degeneration) indicates that MIBG


vacuolar degeneration [SEP] ed dose-dependently in adriamycin cardiomyopathy. The degree of vacuolar degeneration of myocardial cells was analyzed in relation to the duration of

Vacuolar myopathy [SEP]


Amnestic syndrome [SEP] Amnestic syndrome associated with propranolol toxicity: a case report.

Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN


propranolol [SEP] Amnestic syndrome associated with propranolol toxicity: a case report.

Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A


toxicity [SEP] Amnestic syndrome associated with propranolol toxicity: a case report.

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


Alzheimer [SEP] An elderly woman developed an Alzheimer-like subacute dementia as a result of propranolol toxicity. Ana

Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention


dementia [SEP] An elderly woman developed an Alzheimer-like subacute dementia as a result of propranolol toxicity. Analysis of the manifestat

Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup


propranolol [SEP] an developed an Alzheimer-like subacute dementia as a result of propranolol toxicity. Analysis of the manifestations showed that severe imp


toxicity [SEP]  an Alzheimer-like subacute dementia as a result of propranolol toxicity. Analysis of the manifestations showed that severe impairment o


ketamine [SEP] SA node of the dog heart in vivo to selective administration of ketamine.

Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl


ketamine [SEP] Effect of ketamine on the SA node of the dog heart was studied in vivo using a sel


depression [SEP]  in doses from 100 microgram to 3 mg into the artery produced a depression of the SA nodal activity by a direct action. This depression wa

Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur


tachycardia [SEP] locker failed to inhibit the occurrence of the ketamine-induced tachycardia, while it was completely abolished in the reserpinized dogs or

Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba


succinylcholine [SEP] The use of serum cholinesterase in succinylcholine apnoea.

Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan


apnoea [SEP] The use of serum cholinesterase in succinylcholine apnoea.

Apnea [SEP] A transient absence of spontaneous respiration.


apnoea [SEP] Fifteen patients demonstrating unexpected prolonged apnoea lasting several hours after succinylcholine have been treated b


succinylcholine [SEP] trating unexpected prolonged apnoea lasting several hours after succinylcholine have been treated by a new preparation of human serum cholinest


Orthostatic hypotension [SEP] Orthostatic hypotension occurs following alpha 2-adrenoceptor blockade in chronic prazo

Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a


prazosin [SEP] nsion occurs following alpha 2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.

Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS


hypertensive [SEP] blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


prazosin [SEP] 1. Studies were performed to evaluate whether chronic prazosin treatment alters the alpha 2-adrenoceptor function for orthosta


hypertensive [SEP] c control of arterial blood pressure in conscious spontaneously hypertensive rats (SHR). 2. Conscious SHR (male 300-350 g) were subjected to


rauwolscine [SEP] ollowing acute administration of prazosin (0.1 mg kg-1 i.p.) or rauwolscine (3 mg kg-1 i.v.). Orthostatic hypotension was determined by the

Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT


Orthostatic hypotension [SEP] of prazosin (0.1 mg kg-1 i.p.) or rauwolscine (3 mg kg-1 i.v.). Orthostatic hypotension was determined by the average decrease (%) in mean arterial pre


orthostatic hypotension [SEP] auwolscine (-16%(-)-33% MAP). However, the head-up tilt induced orthostatic hypotension in the SHR treated with prazosin (-16% MAP, n = 6), but not in


bradycardia [SEP] ps of MAP by 19-23% in these rats. 4. The pressor responses and bradycardia to the alpha 1-agonist cirazoline (0.6 and 2 micrograms kg-1 i.

Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th


cirazoline [SEP] 4. The pressor responses and bradycardia to the alpha 1-agonist cirazoline (0.6 and 2 micrograms kg-1 i.v.), the alpha 2-agonist Abbott-53

cirazoline [SEP]


Abbott-53693 [SEP] irazoline (0.6 and 2 micrograms kg-1 i.v.), the alpha 2-agonist Abbott-53693 (1 and 3 micrograms kg-1 i.v.), and noradrenaline (0.1 and 1.0

A 53693 [SEP]


noradrenaline [SEP] lpha 2-agonist Abbott-53693 (1 and 3 micrograms kg-1 i.v.), and noradrenaline (0.1 and 1.0 micrograms kg-1 i.v.) were determined in conscious


internal carotid artery thrombosis [SEP] Coexistence of cerebral venous sinus and internal carotid artery thrombosis associated with exogenous sex hormones. A case report.

Carotid Artery Thrombosis [SEP] Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading


headache [SEP] A forty-six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days aft

Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH


nausea [SEP] A forty-six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after paren

Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti


vomiting [SEP] six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of

Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.


hemiparesis [SEP] emenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of progesterone and e

Paresis [SEP] A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe


seizure [SEP] n developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of progesterone and estradiol. Di

Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br


progesterone [SEP] , left hemiparesis and seizure two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admissio

Progesterone [SEP] The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTER


estradiol [SEP] s and seizure two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed to

Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet


Diabetes mellitus [SEP] re two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed tomography showed a h

Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.


DM [SEP] arenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed tomography showed a hemor


hemorrhagic [SEP] s (DM) was found during admission. Computed tomography showed a hemorrhagic infarct in the right frontal lobe and increased density in the

Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with


infarct [SEP] ound during admission. Computed tomography showed a hemorrhagic infarct in the right frontal lobe and increased density in the superior

Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th


occlusion of the left internal carotid artery [SEP] e superior sagittal sinus (SSS). Left carotid angiography found occlusion of the left internal carotid artery (ICA). Right carotid angiograms failed to show the SSS and infe

Arterial Occlusive Diseases [SEP] Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduce


venous sinus thrombosis [SEP] iled to show the SSS and inferior sagittal sinus, suggestive of venous sinus thrombosis. Coexistence of the cerebral artery and the venous sinus occlus

Sinus Thrombosis, Intracranial [SEP] Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within


Chloroquine [SEP] Chloroquine related complete heart block with blindness: case report.

Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth


heart block [SEP] Chloroquine related complete heart block with blindness: case report.

Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE


blindness [SEP] Chloroquine related complete heart block with blindness: case report.

Blindness [SEP] The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; O


chloroquine [SEP] A 27-year old African woman with history of regular chloroquine ingestion presented with progressive deterioration of vision, e


deterioration of vision [SEP] ory of regular chloroquine ingestion presented with progressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopa

Vision, Low [SEP] Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility.


fatiguability [SEP] estion presented with progressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmo

Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re


dyspnoea [SEP] d with progressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmological as

Dyspnea [SEP] Difficult or labored breathing.


dizziness [SEP] gressive deterioration of vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmological assessment re

Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.


syncopal attacks [SEP]  vision, easy fatiguability, dyspnoea, dizziness progressing to syncopal attacks. Ophthalmological assessment revealed features of chloroquine r

Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync


retinopathy [SEP] s. Ophthalmological assessment revealed features of chloroquine retinopathy, cardiac assessment revealed features of heart failure and a co

Retinal Diseases [SEP]


heart failure [SEP] hloroquine retinopathy, cardiac assessment revealed features of heart failure and a complete heart block with right bundle branch block patte

Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear


heart block [SEP] ac assessment revealed features of heart failure and a complete heart block with right bundle branch block pattern. The heart block was tre


right bundle branch block [SEP] ealed features of heart failure and a complete heart block with right bundle branch block pattern. The heart block was treated by pacemaker insertion and

Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU


blind [SEP] usly following chloroquine discontinuation. She however remains blind.


toxicity [SEP] Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivac

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


bupivacaine [SEP] Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.

Bupivacaine [SEP] A widely used local anesthetic agent.


levobupivacaine [SEP] Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.

levobupivacaine [SEP]


ropivacaine [SEP] oxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.

ropivacaine [SEP]


toxicity [SEP] We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetize


bupivacaine [SEP] We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also


levobupivacaine [SEP] We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the abi

levobupivacaine [SEP]


ropivacaine [SEP] ared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the ability to resuscita

ropivacaine [SEP]


Bupivacaine [SEP] resuscitate rats after lethal doses of these local anesthetics. Bupivacaine, levobupivacaine, or ropivacaine was infused at a rate of 2 mg.


asystole [SEP] logram, and arterial pressure were continuously monitored. When asystole was recorded, drug infusion was stopped and a resuscitation seq

Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c


Epinephrine [SEP] ug infusion was stopped and a resuscitation sequence was begun. Epinephrine 0.01 mg/kg was administered at 1-min intervals while external c

Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes


seizures [SEP] mulative doses of levobupivacaine and ropivacaine that produced seizures were similar and were larger than those of bupivacaine. The cum

Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br


dysrhythmias [SEP] ivacaine. The cumulative doses of levobupivacaine that produced dysrhythmias and asystole were smaller than the corresponding doses of ropiv

Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by


epinephrine [SEP] tations did not differ among groups. However, a smaller dose of epinephrine was required in the Ropivacaine group than in the other groups.


Ropivacaine [SEP] ups. However, a smaller dose of epinephrine was required in the Ropivacaine group than in the other groups. We conclude that the systemic t

ropivacaine [SEP]


cardiac arrest [SEP] when administered at the same rate and that ropivacaine-induced cardiac arrest appears to be more susceptible to treatment than that induced b


22-oxacalcitriol [SEP] 22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low b

maxacalcitol [SEP]


secondary hyperparathyroidism [SEP] 22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure.

Hyperparathyroidism, Secondary [SEP] Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other


low bone turnover [SEP] triol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure.

Bone Diseases, Metabolic [SEP]


renal failure [SEP] rparathyroidism without inducing low bone turnover in dogs with renal failure.

Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain


Calcitriol [SEP] BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in

Calcitriol [SEP] The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxychole


renal failure [SEP] sses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marke


hypercalcemia [SEP] atients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to a

Hypercalcemia [SEP] Abnormally high level of calcium in the blood.


suppression of bone turnover [SEP] ut has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analo

Bone Diseases, Metabolic [SEP]


adynamic bone disease [SEP] a and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been sho

Bone Diseases, Metabolic [SEP]


vitamin D [SEP] f bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promis

Vitamin D [SEP] A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS


22-oxacalcitriol [SEP] ch may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This s

maxacalcitol [SEP]


OCT [SEP] namic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study

maxacalcitol [SEP]


impaired renal function [SEP] CT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or

Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.


phosphate [SEP] sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of pho

Phosphates [SEP] Inorganic salts of phosphoric acid.


calcium [SEP] an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bon

Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym


renal insufficiency [SEP] ficantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 micr


secondary hyperparathyroidism [SEP] on after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the fi


hyperphosphatemia [SEP] These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient

Hyperphosphatemia [SEP] A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol


fibrosis [SEP] OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In

Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other


low bone turnover [SEP] ent of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone dis

Bone Diseases, Metabolic [SEP]


non-small cell lung cancer [SEP] Chemotherapy of advanced inoperable non-small cell lung cancer with paclitaxel: a phase II trial.

Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO


paclitaxel [SEP] otherapy of advanced inoperable non-small cell lung cancer with paclitaxel: a phase II trial.

Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized


Paclitaxel [SEP] Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has demons


Taxol [SEP] Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has demonstrated


tumor [SEP] onstrated significant antineoplastic activity against different tumor types, notably ovarian and breast carcinoma. Two phase II trial

Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me


breast carcinoma [SEP] tic activity against different tumor types, notably ovarian and breast carcinoma. Two phase II trials of 24-hour paclitaxel infusions in chemoth

Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.


paclitaxel [SEP] ly ovarian and breast carcinoma. Two phase II trials of 24-hour paclitaxel infusions in chemotherapy-naive patients with stage IIIB or IV


non-small cell lung cancer [SEP]  infusions in chemotherapy-naive patients with stage IIIB or IV non-small cell lung cancer (NSCLC) reported response rates of 21% and 24%. Leukopenia was


NSCLC [SEP] aive patients with stage IIIB or IV non-small cell lung cancer (NSCLC) reported response rates of 21% and 24%. Leukopenia was dose li


Leukopenia [SEP] ell lung cancer (NSCLC) reported response rates of 21% and 24%. Leukopenia was dose limiting: as many as 62.5% of patients experienced gra

Leukopenia [SEP]


leukopenia [SEP] dose limiting: as many as 62.5% of patients experienced grade 4 leukopenia. We investigated the efficacy and toxicity of a 3-hour paclitax

Leukopenia [SEP]


toxicity [SEP] xperienced grade 4 leukopenia. We investigated the efficacy and toxicity of a 3-hour paclitaxel infusion in a phase II trial in patients

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


toxicities [SEP] ad no change, and 12 had disease progression (24%). Hematologic toxicities were mild: only one patient (2%) developed grade 3 or 4 neutrop


neutropenia [SEP] icities were mild: only one patient (2%) developed grade 3 or 4 neutropenia, while 29% had grade 1 or 2. Grade 1 or 2 polyneuropathy affect

Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.


polyneuropathy [SEP] de 3 or 4 neutropenia, while 29% had grade 1 or 2. Grade 1 or 2 polyneuropathy affected 56% of patients while only one (2%) experienced severe

Polyneuropathies [SEP] Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral dist


myalgia [SEP] (2%) experienced severe polyneuropathy. Similarly, grade 1 or 2 myalgia/arthralgia was observed in 63.2% of patients, but only 14.3% ex

Myalgia [SEP] Painful sensation in the muscles.


arthralgia [SEP] erienced severe polyneuropathy. Similarly, grade 1 or 2 myalgia/arthralgia was observed in 63.2% of patients, but only 14.3% experienced g

Arthralgia [SEP] Pain in the joint.


Nausea [SEP]  in 63.2% of patients, but only 14.3% experienced grade 3 or 4. Nausea and vomiting were infrequent, with 14% of patients experiencing

Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti


vomiting [SEP] f patients, but only 14.3% experienced grade 3 or 4. Nausea and vomiting were infrequent, with 14% of patients experiencing grade 1 or 2

Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.


Cerebral hemorrhage [SEP] Cerebral hemorrhage associated with phenylpropanolamine in combination with caffein

Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with


phenylpropanolamine [SEP] Cerebral hemorrhage associated with phenylpropanolamine in combination with caffeine.

Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic


caffeine [SEP] orrhage associated with phenylpropanolamine in combination with caffeine.

Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac


Phenylpropanolamine [SEP] Phenylpropanolamine (PPA) is a drug that has been associated with serious side effe


PPA [SEP] Phenylpropanolamine (PPA) is a drug that has been associated with serious side effects i


stroke [SEP] ug that has been associated with serious side effects including stroke. It is often combined with caffeine in diet preparations and "l

Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o


caffeine [SEP] erious side effects including stroke. It is often combined with caffeine in diet preparations and "look-alike" pills. In order to determ


hypertensive [SEP] rmine if PPA/caffeine can lead to stroke in normotensive and/or hypertensive rats, we administered the combination in six times the allowed

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


cerebral hemorrhage [SEP]  for the rats two times per day for five days. Subarachnoid and cerebral hemorrhage was noted in 18% of the hypertensive rats. A single PPA/caffein


hypertension [SEP]  A single PPA/caffeine administration (same dose) lead to acute hypertension in both the normotensive and hypertensive animals. These result


toxicity [SEP] Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or


amiodarone [SEP] Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation

Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin


ventricular tachycardia [SEP] -term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.

Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the


ventricular fibrillation [SEP]  of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.

Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40


Amiodarone [SEP] Amiodarone was administered to 154 patients who had sustained, symptomatic


ventricular tachycardia [SEP] was administered to 154 patients who had sustained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refrac


VT [SEP] atients who had sustained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refractory


cardiac arrest [SEP] tained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refractory to conventional antiarrhythmic

Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c


amiodarone [SEP] mg/day. Sixty-nine percent of patients continued treatment with amiodarone and had no recurrence of symptomatic VT or ventricular fibrilla


ventricular fibrillation [SEP] ment with amiodarone and had no recurrence of symptomatic VT or ventricular fibrillation (VF) over a follow-up of 6 to 52 months (mean +/- standard devi


VF [SEP] ad no recurrence of symptomatic VT or ventricular fibrillation (VF) over a follow-up of 6 to 52 months (mean +/- standard deviatio


tremor [SEP] of patients. The most common symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blur

Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act


ataxia [SEP] s. The most common symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%),

Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,


nausea [SEP] mmon symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid funct


anorexia [SEP] matic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormali

Anorexia [SEP] The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of t


visual halos or blurring [SEP] eactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormalities (6%) and pulmonary interst

Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri


thyroid function abnormalities [SEP] (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormalities (6%) and pulmonary interstitial infiltrates (5%). Although larg

Thyroid Diseases [SEP] Pathological processes involving the THYROID GLAND.


toxicity [SEP] ory to conventional antiarrhythmic drugs, it causes significant toxicity in approximately 50% of patients. However, when the dose is adj

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


calcium chloride [SEP] Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.

Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.


4-aminopyridine [SEP] Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.

4-Aminopyridine [SEP] One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to


desipramine [SEP] Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.

Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine


toxicity [SEP]  of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.


Hypotension [SEP] BACKGROUND: Hypotension is a major contributor to mortality in tricyclic antidepressant

Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI


overdose [SEP] is a major contributor to mortality in tricyclic antidepressant overdose. Recent data suggest that tricyclic antidepressants inhibit cal

Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.


calcium [SEP] ose. Recent data suggest that tricyclic antidepressants inhibit calcium influx in some tissues. This study addressed the potential role

Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym


hypotension [SEP] of calcium channel blockade in tricyclic antidepressant-induced hypotension. METHODS: Two interventions were studied that have been shown p


CaCl2 [SEP] o improve blood pressure with calcium channel blocker overdose. CaCl2 and 4-aminopyridine. Anesthetized rats received the tricyclic a


4-aminopyridine [SEP] blood pressure with calcium channel blocker overdose. CaCl2 and 4-aminopyridine. Anesthetized rats received the tricyclic antidepressant desipr


desipramine [SEP] ridine. Anesthetized rats received the tricyclic antidepressant desipramine IP to produce hypotension, QRS prolongation, and bradycardia. F


bradycardia [SEP] nt desipramine IP to produce hypotension, QRS prolongation, and bradycardia. Fifteen min later, animals received CaCl2, NaHCO3, or saline.

Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th


NaHCO3 [SEP] on, and bradycardia. Fifteen min later, animals received CaCl2, NaHCO3, or saline. In a second experiment, rats received tricyclic ant

Sodium Bicarbonate [SEP] A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in


ventricular arrhythmias [SEP] minopyridine failed to improve blood pressure. The incidence of ventricular arrhythmias (p = 0.004) and seizures (p = 0.03) in the CaCl2 group was high

Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by


seizures [SEP] ssure. The incidence of ventricular arrhythmias (p = 0.004) and seizures (p = 0.03) in the CaCl2 group was higher than the other groups.

Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br


central nervous system toxicity [SEP] rats. CaCl2 therapy may possibly worsen both cardiovascular and central nervous system toxicity. These findings do not support a role for calcium channel inhib

Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi


13-cis-retinoic acid [SEP] Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplant

Isotretinoin [SEP] A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has terato


neuroblastoma [SEP] Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation.

Neuroblastoma [SEP] A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by div


neuroblastoma [SEP] PURPOSE: Treatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustain


13-cis-retinoic acid [SEP] PURPOSE: Treatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustained inhibition of proliferation. Since


cis-RA [SEP] reatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustained inhibition of proliferation. Since cis-RA


toxicities [SEP] l was designed to determine the maximal-tolerated dosage (MTD), toxicities, and pharmacokinetics of cis-RA administered on an intermittent


toxicity [SEP]  dose was escalated from 100 to 200 mg/m2/d until dose-limiting toxicity (DLT) was observed. A single intrapatient dose escalation was p


hypercalcemia [SEP] ting toxicities in six of nine patients at 200 mg/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash

Hypercalcemia [SEP] Abnormally high level of calcium in the blood.


rash [SEP] of nine patients at 200 mg/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All t

Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim


anemia [SEP] t 200 mg/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All toxicities resolved a

Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.


thrombocytopenia [SEP] g/m2/d included hypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All toxicities resolved after cis-RA was d

Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.


emesis [SEP] ypercalcemia (n = 3), rash (n = 2), and anemia/thrombocytopenia/emesis/rash (n = 1). All toxicities resolved after cis-RA was disconti

Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.


metastases [SEP]  discontinued. Three complete responses were observed in marrow metastases. Serum levels of 7.4 +/- 3.0 mumol/L (peak) and 4.0 +/- 2.8 mum

Neoplasm Metastasis [SEP] The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.


calcium [SEP] nd may be predicted by serum cis-RA levels. Monitoring of serum calcium and cis-RA levels is indicated in future trials.


calcium chloride [SEP] Effect of calcium chloride on gross behavioural changes produced by carbachol and eserine

Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.


carbachol [SEP] ct of calcium chloride on gross behavioural changes produced by carbachol and eserine in cats.

Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.


eserine [SEP] chloride on gross behavioural changes produced by carbachol and eserine in cats.

Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c


calcium chloride [SEP] The effect of calcium chloride injected into the cerebral ventricles of group-housed unanaesth


mydriasis [SEP] k with paws and claws, defense with paws and claws and biting), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and

Mydriasis [SEP] Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condit


tremor [SEP]  and claws, defense with paws and claws and biting), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and eserine

Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act


clonic-tonic convulsions [SEP]  defense with paws and claws and biting), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and eserine injected similarly was invest

Epilepsy, Tonic-Clonic [SEP] A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk


carbachol [SEP] ng), mydriasis, tremor and clonic-tonic convulsions produced by carbachol and eserine injected similarly was investigated. Calcium chlori


eserine [SEP] , tremor and clonic-tonic convulsions produced by carbachol and eserine injected similarly was investigated. Calcium chloride depressed


Calcium chloride [SEP] d by carbachol and eserine injected similarly was investigated. Calcium chloride depressed or almost completely abolished the vocalization and f


calcium [SEP] The effect of calcium chloride injected into the cerebral ventricles of group-housed

Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym


atropine [SEP] ts further support the view that calcium ions in excess have an atropine-like action also in the central nervous system.

Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome


penicillamine [SEP] Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.

Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a


rheumatoid arthritis [SEP] tiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.

Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru


Skin rashes [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and my


proteinuria [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia grav

Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.


systemic lupus erythematosus [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as c

Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by


polymyositis [SEP] Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications o

Polymyositis [SEP] Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated wi


myasthenia gravis [SEP] es, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therap

Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai


penicillamine [SEP] nd myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis. A patient who ha


rheumatoid arthritis [SEP] rded as complications of penicillamine therapy in patients with rheumatoid arthritis. A patient who had developed all 5 is now described. The skin l


skin lesion [SEP] hritis. A patient who had developed all 5 is now described. The skin lesion resembled elastosis perforans serpiginosa, which has been repor

Skin Diseases [SEP]


elastosis perforans serpiginosa [SEP] had developed all 5 is now described. The skin lesion resembled elastosis perforans serpiginosa, which has been reported as a rare side effect in patients with

Elastosis perforans serpiginosa [SEP]


Wilson's disease [SEP]  which has been reported as a rare side effect in patients with Wilson's disease but not in patients with rheumatoid arthritis treated with peni

Hepatolenticular Degeneration [SEP] A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It i


cardiac arrhythmias [SEP] Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.

Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by


phenothiazines [SEP] ife-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were recei

Phenothiazines [SEP] Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.


Mellaril [SEP] pressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ven

Thioridazine [SEP] A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.


thioridazine [SEP]  Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachy


ventricular tachycardia [SEP] ril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricula

Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the


Supraventricular tachycardia [SEP] lar tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine).

Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.


Thorazine [SEP] Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitripty

Chlorpromazine [SEP] The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are


chlorpromazine [SEP] cular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produ


Aventyl [SEP]  developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left b

Nortriptyline [SEP] A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia


nortriptyline [SEP] d in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch bl


Elavil [SEP] ceiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73

Amitriptyline [SEP] Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and


amitriptyline [SEP] Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman.


left bundle branch block [SEP] ventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnor

Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU


ventricular arrhythmias [SEP] c T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to dir


lidocaine [SEP] tricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was re

Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro


propranolol [SEP] as required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias g

Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A


tachyarrhythmias [SEP] ion of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the

Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba


heart disease [SEP] ere 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients w

Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.


cardiac arrhythmias [SEP] r younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who ar


cardiac complications [SEP] prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressan

Cardiac Complexes, Premature [SEP] A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atr


benzodiazepines [SEP] Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain

Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.


baclofen [SEP] Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.

Baclofen [SEP] A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPAST


muscimol [SEP] Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.

Muscimol [SEP] A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a poten


myoclonic jerks [SEP] rgic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.

Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle


muscimol [SEP] In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this re


myoclonic jerks [SEP] In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this response in all of the mice


serotonin [SEP] er min was observed between 27 and 45 min. Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/

Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i


5-hydroxytryptophan [SEP]  Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/kg) in combination with a peripheral decarboxylase i

5-Hydroxytryptophan [SEP] The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.


l-dopa [SEP] bition of the muscimol effect. However, in a similar experiment l-dopa (80-160 mg/kg) was without effect. In doses of 3-10 mg/kg, the

Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b


MK-212 [SEP]  effect. In doses of 3-10 mg/kg, the serotonin receptor agonist MK-212 caused a dose-dependent blockade of the response of muscimol. O

MK 212 [SEP]


benzodiazepines [SEP] d a dose-dependent blockade of the response of muscimol. Of the benzodiazepines, clonazepam (0.1-0.3 mg/kg) was found to be several fold more p


clonazepam [SEP] t blockade of the response of muscimol. Of the benzodiazepines, clonazepam (0.1-0.3 mg/kg) was found to be several fold more potent than d

Clonazepam [SEP] An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absenc


diazepam [SEP] m (0.1-0.3 mg/kg) was found to be several fold more potent than diazepam (0.3-3 mg/kg) in blocking the myoclonic jerks. While (-)-baclof

Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio


baclofen [SEP] azepam (0.3-3 mg/kg) in blocking the myoclonic jerks. While (-)-baclofen (1-3 mg/kg) proved to be an effective antagonist of muscimol, i


5-HTP [SEP] er (5-20 mg/kg) lacked this property. Considering the fact that 5-HTP and the benzodiazepines have been found to be beneficial in the


myoclonus [SEP]  have been found to be beneficial in the management of clinical myoclonus, the muscimol-induced myoclonus seems to be a satisfactory anim


Hyperglycemic [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.

Hyperglycemia [SEP] Abnormally high BLOOD GLUCOSE level.


acidotic [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.

Acidosis, Lactic [SEP] Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in associa


coma [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.

Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com


Kearns-Sayre syndrome [SEP] Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.

Kearns-Sayre Syndrome [SEP] A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES)


Kearns-Sayre syndrome [SEP] cal and metabolic findings in two young boys with long-standing Kearns-Sayre syndrome. Following short exposure to oral prednisone, both boys develop


prednisone [SEP] tanding Kearns-Sayre syndrome. Following short exposure to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsi

Prednisone [SEP] A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in t


lethargy [SEP] ollowing short exposure to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. B

Lethargy [SEP] A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simp


somnolence [SEP] re to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the em

Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr


polydipsia [SEP] rednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the emergency room

Polydipsia [SEP] Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES


polyphagia [SEP] oth boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the emergency room with profou

Hyperphagia [SEP] Ingestion of a greater than optimal quantity of food.


polyuria [SEP] ed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria. Both presented in the emergency room with profound coma, hypot

Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET


coma [SEP] nd polyuria. Both presented in the emergency room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic la


hypotension [SEP] yuria. Both presented in the emergency room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis

Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI


hyperglycemia [SEP] d in the emergency room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis was present in one an


acidosis [SEP] room with profound coma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis was present in one and ketosis with

Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me


lactic acidosis [SEP] ma, hypotension, severe hyperglycemia, and acidosis. Nonketotic lactic acidosis was present in one and ketosis without a known serum lactate le


ketosis [SEP] and acidosis. Nonketotic lactic acidosis was present in one and ketosis without a known serum lactate level was present in the other. R

Ketosis [SEP] A condition characterized by an abnormally elevated concentration of KETONE BODIES in the blood (acetonemia) or urine (acetonuri


lactate [SEP] c acidosis was present in one and ketosis without a known serum lactate level was present in the other. Respiratory failure rapidly ens

Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent


Respiratory failure [SEP] s without a known serum lactate level was present in the other. Respiratory failure rapidly ensued and both patients expired in spite of efforts at

Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)


crocin [SEP] Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease i

crocin [SEP]


streptozocin [SEP] Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats.

Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe


Alzheimer's disease [SEP] us sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats.

Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention


carotenoids [SEP] BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L

Carotenoids [SEP] The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are a


crocins [SEP] BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extract

crocin [SEP]


Alzheimer's disease [SEP] oposed. In the present study, the effect of crocins on sporadic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in


streptozocin [SEP] ic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. METHODS: Male adult Wistar


STZ [SEP]  disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. METHODS: Male adult Wistar rats


crocin [SEP] BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extrac

crocin [SEP]


memory impairment [SEP]  the mentioned dose could significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. CONCLU

Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory


cognitive deficits [SEP] rate the effectiveness of crocin (30 mg/kg) in antagonizing the cognitive deficits caused by STZ-icv in rats and its potential in the treatment of

Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.


neurodegenerative diseases [SEP] caused by STZ-icv in rats and its potential in the treatment of neurodegenerative diseases such as Alzheimer's disease.

Neurodegenerative Diseases [SEP] Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often


dermatitis [SEP] Rosaceiform dermatitis associated with topical tacrolimus treatment.

Dermatitis [SEP] Any inflammation of the skin.


tacrolimus [SEP] Rosaceiform dermatitis associated with topical tacrolimus treatment.

Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity


rosacea [SEP] We describe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus

Rosacea [SEP] A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is ch


dermatitis [SEP] We describe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for fac


eruptions [SEP] escribe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for facial dermat

Drug Eruptions [SEP] Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morpho