tasks.json

[
  {
    "display_name": "Enzyme",
    "evidence_rule": "experimental GO catalytic activity or UniProt ECO:0000269 EC assertion",
    "evidence_tier": "experimental",
    "family": "enzyme",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "enzyme",
    "negative_basis": "experimental molecular-function evidence outside the catalytic-activity subtree, with no EC or catalytic annotation",
    "negative_count": 13016,
    "negative_definition": "Experimental molecular-function evidence outside catalytic activity, with no EC or catalytic annotation.",
    "positive_count": 8287,
    "positive_definition": "Experimental EC assignment or experimental GO catalytic-activity evidence.",
    "reference_test_mcc": 0.6232,
    "source_ids": [
      "enzyme"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Distinguishes experimentally supported enzymes from proteins with experimentally supported non-catalytic molecular functions.",
    "task_id": "enzyme",
    "term": "enzyme",
    "tier": "required broad task"
  },
  {
    "display_name": "Immune system process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0002376",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 19175,
    "negative_definition": "Experimental NOT evidence for immune system process, or experimental evidence for another biological process, with no positive annotation to immune system process.",
    "positive_count": 830,
    "positive_definition": "Experimental GO evidence for immune system process (GO:0002376), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.3209,
    "source_ids": [
      "GO:0002376"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that participate in immune-system development, activation, or defense.",
    "task_id": "go__go_0002376",
    "term": "GO:0002376",
    "tier": "required broad task"
  },
  {
    "display_name": "Regulation of immune system process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0002682",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 19311,
    "negative_definition": "Experimental NOT evidence for regulation of immune system process, or experimental evidence for another biological process, with no positive annotation to regulation of immune system process.",
    "positive_count": 772,
    "positive_definition": "Experimental GO evidence for regulation of immune system process (GO:0002682), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2539,
    "source_ids": [
      "GO:0002682"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that increase, decrease, or otherwise tune an immune-system process.",
    "task_id": "go__go_0002682",
    "term": "GO:0002682",
    "tier": "additional GO task"
  },
  {
    "display_name": "DNA binding",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0003677",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 18159,
    "negative_definition": "Experimental NOT evidence for DNA binding, or experimental evidence for another molecular function, with no positive annotation to DNA binding.",
    "positive_count": 2051,
    "positive_definition": "Experimental GO evidence for DNA binding (GO:0003677), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.6333,
    "source_ids": [
      "GO:0003677"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that bind DNA selectively and non-covalently.",
    "task_id": "go__go_0003677",
    "term": "GO:0003677",
    "tier": "required broad task"
  },
  {
    "display_name": "Nucleus",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0005634",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 13719,
    "negative_definition": "Experimental NOT evidence for nucleus, or experimental evidence for another cellular component, with no positive annotation to nucleus.",
    "positive_count": 7223,
    "positive_definition": "Experimental GO evidence for nucleus (GO:0005634), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.7145,
    "source_ids": [
      "GO:0005634"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins experimentally localized to the cell nucleus.",
    "task_id": "go__go_0005634",
    "term": "GO:0005634",
    "tier": "additional GO task"
  },
  {
    "display_name": "Cytoplasm",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0005737",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 8418,
    "negative_definition": "Experimental NOT evidence for cytoplasm, or experimental evidence for another cellular component, with no positive annotation to cytoplasm.",
    "positive_count": 11962,
    "positive_definition": "Experimental GO evidence for cytoplasm (GO:0005737), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.3529,
    "source_ids": [
      "GO:0005737"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins experimentally localized to the cytoplasm.",
    "task_id": "go__go_0005737",
    "term": "GO:0005737",
    "tier": "additional GO task"
  },
  {
    "display_name": "Regulation of transcription by RNA polymerase II",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0006357",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 18062,
    "negative_definition": "Experimental NOT evidence for regulation of transcription by RNA polymerase II, or experimental evidence for another biological process, with no positive annotation to regulation of transcription by RNA polymerase II.",
    "positive_count": 1606,
    "positive_definition": "Experimental GO evidence for regulation of transcription by RNA polymerase II (GO:0006357), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.5866,
    "source_ids": [
      "GO:0006357"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that control transcription carried out by RNA polymerase II.",
    "task_id": "go__go_0006357",
    "term": "GO:0006357",
    "tier": "additional GO task"
  },
  {
    "display_name": "Immune response",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0006955",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 19550,
    "negative_definition": "Experimental NOT evidence for immune response, or experimental evidence for another biological process, with no positive annotation to immune response.",
    "positive_count": 514,
    "positive_definition": "Experimental GO evidence for immune response (GO:0006955), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.3706,
    "source_ids": [
      "GO:0006955"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that execute or support an immune response.",
    "task_id": "go__go_0006955",
    "term": "GO:0006955",
    "tier": "additional GO task"
  },
  {
    "display_name": "Signal transduction",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0007165",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 17278,
    "negative_definition": "Experimental NOT evidence for signal transduction, or experimental evidence for another biological process, with no positive annotation to signal transduction.",
    "positive_count": 1875,
    "positive_definition": "Experimental GO evidence for signal transduction (GO:0007165), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2924,
    "source_ids": [
      "GO:0007165"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that convert an internal or external signal into a cellular response.",
    "task_id": "go__go_0007165",
    "term": "GO:0007165",
    "tier": "additional GO task"
  },
  {
    "display_name": "Regulation of signal transduction",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0009966",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 18089,
    "negative_definition": "Experimental NOT evidence for regulation of signal transduction, or experimental evidence for another biological process, with no positive annotation to regulation of signal transduction.",
    "positive_count": 1749,
    "positive_definition": "Experimental GO evidence for regulation of signal transduction (GO:0009966), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.3916,
    "source_ids": [
      "GO:0009966"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that increase, decrease, or otherwise tune signal transduction.",
    "task_id": "go__go_0009966",
    "term": "GO:0009966",
    "tier": "additional GO task"
  },
  {
    "display_name": "Positive regulation of macromolecule biosynthetic process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0010557",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 17638,
    "negative_definition": "Experimental NOT evidence for positive regulation of macromolecule biosynthetic process, or experimental evidence for another biological process, with no positive annotation to positive regulation of macromolecule biosynthetic process.",
    "positive_count": 2092,
    "positive_definition": "Experimental GO evidence for positive regulation of macromolecule biosynthetic process (GO:0010557), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.4791,
    "source_ids": [
      "GO:0010557"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that increase the synthesis of cellular macromolecules.",
    "task_id": "go__go_0010557",
    "term": "GO:0010557",
    "tier": "additional GO task"
  },
  {
    "display_name": "Negative regulation of macromolecule metabolic process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0010605",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 17614,
    "negative_definition": "Experimental NOT evidence for negative regulation of macromolecule metabolic process, or experimental evidence for another biological process, with no positive annotation to negative regulation of macromolecule metabolic process.",
    "positive_count": 2242,
    "positive_definition": "Experimental GO evidence for negative regulation of macromolecule metabolic process (GO:0010605), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.3934,
    "source_ids": [
      "GO:0010605"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that decrease metabolic processing of cellular macromolecules.",
    "task_id": "go__go_0010605",
    "term": "GO:0010605",
    "tier": "additional GO task"
  },
  {
    "display_name": "Cellular component organization",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0016043",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 13716,
    "negative_definition": "Experimental NOT evidence for cellular component organization, or experimental evidence for another biological process, with no positive annotation to cellular component organization.",
    "positive_count": 5250,
    "positive_definition": "Experimental GO evidence for cellular component organization (GO:0016043), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2739,
    "source_ids": [
      "GO:0016043"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins involved in forming, arranging, or dismantling cellular structures.",
    "task_id": "go__go_0016043",
    "term": "GO:0016043",
    "tier": "additional GO task"
  },
  {
    "display_name": "Macromolecule metabolic process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0043170",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 13669,
    "negative_definition": "Experimental NOT evidence for macromolecule metabolic process, or experimental evidence for another biological process, with no positive annotation to macromolecule metabolic process.",
    "positive_count": 5364,
    "positive_definition": "Experimental GO evidence for macromolecule metabolic process (GO:0043170), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2825,
    "source_ids": [
      "GO:0043170"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins involved in reactions and pathways that transform macromolecules.",
    "task_id": "go__go_0043170",
    "term": "GO:0043170",
    "tier": "additional GO task"
  },
  {
    "display_name": "Intracellular membraneless organelle",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0043232",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 16221,
    "negative_definition": "Experimental NOT evidence for intracellular membraneless organelle, or experimental evidence for another cellular component, with no positive annotation to intracellular membraneless organelle.",
    "positive_count": 4677,
    "positive_definition": "Experimental GO evidence for intracellular membraneless organelle (GO:0043232), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.4476,
    "source_ids": [
      "GO:0043232"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins localized to an intracellular structure without a surrounding membrane.",
    "task_id": "go__go_0043232",
    "term": "GO:0043232",
    "tier": "additional GO task"
  },
  {
    "display_name": "Primary metabolic process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0044238",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 12130,
    "negative_definition": "Experimental NOT evidence for primary metabolic process, or experimental evidence for another biological process, with no positive annotation to primary metabolic process.",
    "positive_count": 6611,
    "positive_definition": "Experimental GO evidence for primary metabolic process (GO:0044238), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2695,
    "source_ids": [
      "GO:0044238"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins involved in core metabolic reactions needed for normal cellular activity.",
    "task_id": "go__go_0044238",
    "term": "GO:0044238",
    "tier": "additional GO task"
  },
  {
    "display_name": "Positive regulation of response to stimulus",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0048584",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 18625,
    "negative_definition": "Experimental NOT evidence for positive regulation of response to stimulus, or experimental evidence for another biological process, with no positive annotation to positive regulation of response to stimulus.",
    "positive_count": 1385,
    "positive_definition": "Experimental GO evidence for positive regulation of response to stimulus (GO:0048584), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.204,
    "source_ids": [
      "GO:0048584"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that increase the strength, rate, or duration of a response to a stimulus.",
    "task_id": "go__go_0048584",
    "term": "GO:0048584",
    "tier": "additional GO task"
  },
  {
    "display_name": "Regulation of multicellular organismal process",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0051239",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 18221,
    "negative_definition": "Experimental NOT evidence for regulation of multicellular organismal process, or experimental evidence for another biological process, with no positive annotation to regulation of multicellular organismal process.",
    "positive_count": 1556,
    "positive_definition": "Experimental GO evidence for regulation of multicellular organismal process (GO:0051239), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2564,
    "source_ids": [
      "GO:0051239"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins that tune a biological process occurring at the multicellular-organism level.",
    "task_id": "go__go_0051239",
    "term": "GO:0051239",
    "tier": "additional GO task"
  },
  {
    "display_name": "Response to other organism",
    "evidence_rule": "experimental GO code with a PMID; positives propagate to ancestors",
    "evidence_tier": "experimental",
    "family": "go",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "go__go_0051707",
    "negative_basis": "experimental NOT or experimental alternative in the same GO aspect",
    "negative_count": 18910,
    "negative_definition": "Experimental NOT evidence for response to other organism, or experimental evidence for another biological process, with no positive annotation to response to other organism.",
    "positive_count": 1215,
    "positive_definition": "Experimental GO evidence for response to other organism (GO:0051707), including annotations propagated from descendant terms.",
    "reference_test_mcc": 0.2663,
    "source_ids": [
      "GO:0051707"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Captures proteins involved in responding to the presence or activity of another organism.",
    "task_id": "go__go_0051707",
    "term": "GO:0051707",
    "tier": "additional GO task"
  },
  {
    "display_name": "Soluble localization",
    "evidence_rule": "experimental GO annotation to a curated soluble-compartment subtree; proteins with any membrane annotation are excluded from positives",
    "evidence_tier": "experimental",
    "family": "solubility",
    "minimum_class_fraction": 0.4,
    "minimum_class_fraction_per_stratum": 0.3,
    "minimum_negative_count_per_split": 100,
    "minimum_positive_count_per_split": 100,
    "name": "soluble",
    "negative_basis": "experimental GO annotation to membrane or a descendant",
    "negative_count": 6922,
    "negative_definition": "Experimental GO localization to membrane or one of its descendant terms.",
    "positive_count": 3684,
    "positive_definition": "Experimental GO localization to a curated soluble compartment and no membrane annotation.",
    "reference_test_mcc": 0.3494,
    "source_ids": [
      "soluble compartment"
    ],
    "stratum_policy": "joint_taxonomic_domain_and_length_bin",
    "summary": "Distinguishes proteins experimentally localized to curated soluble compartments from experimentally membrane-localized proteins.",
    "task_id": "soluble",
    "term": "soluble compartment",
    "tier": "required broad task"
  }
]