ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q9CYC3
MPSRRRGPSRQQLSRSALPSIQTLVGGGCGNGTGLRNRNGNAIGLPVPPTTALITPGPVRHCQIPDLPVDGSLFFEFLFFIYLLIVLFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYYLAAFITVMLARRLVWALISEATKAGAASTVHYTALILARLVLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLYCFHQDSRAHLLLTDYVVQHQAVEEAASNVGSLARSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHL...
Function: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity). Location Top...
Q6GL42
MPGGRRGPSRQQLSRSALPSLQTLVGGTCGNGTGLRNRNGSAIGLSAPPITALITPEPVRHCHIPELPLDGGLLFEFLFFIYLLVALFIQYINIYKSVWWYPYNHPASCTSLNFHLIDYHLAAFITVMLARRLVWALISEASQVGTSSMVHYAALITARLVLLTLCGWVFCWTLVNLFRNHSVLNLLFLGYPFGVYVPLCCFHQDSRSQPLPTDCGYLVQDPLVDDGANGMATLVRPRDFLSLLRESLREQFNSTPSIPSHSCPLSPDLIRNEVECLKADFNRRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCE...
Function: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity). Location Top...
Q7ZW11
MAGGRRGANRTTYCRSPLSNDTGSVGNGNHSTSSPVTGVRSRTRNGSGTGMSSPPLATQTVVPLKHCKIPELSMDKNVLFELHLFACHLIALFVHYVNIYKTVWWYPPSHPPSHTSLNFHLIDYNMLVFTVIVLARRLIAAIVKEASQSGKLSFPHSVFLVTARFAVLTLAGWSLCRSLIYLFKTYSVLSLLFLCYPFGMYIPFFRLSCDFRRAGSMSPLSGIGSKDVGAAALGRGGRDYLSVLKETWKQHTSQLYSAQPMPTHACCLSPDLIRKEVEYLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKSTQYVDKRW...
Function: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55776 Sequence Length: 491 Subcellular Location: Endoplasmic reticulum membrane
Q9GZU3
MGGRRGPNRTSYCRNPLCEPGSSGGSSGSHTSSASVTSVRSRTRSSSGTGLSSPPLATQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHPPSHTSLNFHLIDFNLLMVTTIVLGRRFIGSIVKEASQRGKVSLFRSILLFLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYPFGMYIPFLQLNCDLRKTSLFNHMASMGPREAVSGLAKSRDYLLTLRETWKQHTRQLYGPDAMPTHACCLSPSLIRSEVEFLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKNTHYYDKRWSC...
Function: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56274 Sequence Length: 492 Subcellular Location: Endoplasmic reticulum membrane
Q810L4
MGGRRGPNRTSYYRNPLCEPGSSGASGGGHSSSASVSSVRSRSRTTSGTGLSSPPLAAQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHPPSHTSLNFHLIDFNLLMVTAIVLGRRFIGSIVKEASQRGKVSLFRSILLFLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYPFGMYIPFLQLNYDLRKTNLFTHMASMGPREAVSGLARSRDYFLTLRETWKQHTRQLYGPEAMPTHACCLSPSLIRNEVEFLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKNTHYYDKRWSC...
Function: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56377 Sequence Length: 492 Subcellular Location: Endoplasmic reticulum membrane
Q969M1
MGNTLGLAPMGTLPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTIHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG
Function: Potential channel-forming protein implicated in import of protein precursors into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 33917 Sequence Length: 308 Subcellular Location: Mitochondrion outer membrane
A4F267
MGNTLGLAPMGTLPRWSHRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHTAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSITHRLVLGGELVYHRRPGEEGAILTLAGKYSALHWVATLNVGSGGAHASYYHKANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQADMVFRGLVDSNWCVGAVLEKKMRPLPVTLALGAFLNHWRNRFHCGFSITVG
Function: Potential channel-forming protein implicated in import of protein precursors into mitochondria. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 34049 Sequence Length: 308 Subcellular Location: Mitochondrion outer membrane
A8MHA3
MKILGLVTEYNPFHNGHRYHLEQSKEITKATHTVAVMSGNFLQRGEPAMVHKWERAKMAVKSGVDLIIELPTSYACATAELFAYGAITLLHRLGSVDCLCFGSEIGNVSPLLQIAEVLSTPTSRFQEVLREHVNLGGTFPVARSMALLKYLEETKEYDVASLREISDALKSPNNILGIEYLKSLKKLNSPIVPYTISRKSADYHSKDITDSSIASATAIREHLLKENHLKGIASVVPKDTLDILAHSVGIGMAPIFATDFQQILLALLRRSTPENLKNIFDVEEGLENRIYHCAHQASTLNELYEAIKSKRYTRTRIQRI...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
P0C0A4
MQQTKKLTQSDIIIAVMSGPFLQRGEPALISKWYRTKMALANGVDLVVELPYVFATQKAETFANGAISILNALRVSEICFGSEDGQIENFYNTISIQKNEEETFNCLVKQFMDAGNSYAKATSDAFSHILTSEKNIDMSQPNNILGFQYMKAILSQNSSIQAQTIKRFASHYHDETFNDQHIASATSIRKQLFSEEGSFTTIEPFLPQATTSLLANYKQNYGILHNWEQYFSFFKYRLMTMSPGDLRHIYEIEEGLEHRILSKIQNSSSFYSFMEALKTKRYTWTRLQRACTHILTNTTKEDIRSANIEQHAPYIRLLGM...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
O34513
MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQRGEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGSENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSKPNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQNLEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGLEHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKK...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
B9MRM7
MRVAGIIVEYNPFHNGHLYHLQKTREITNADIVVGVMSGNFIQRGEPAIVNKWARTKMAILNGVDVIFELPFAYACNSAEIFAYGAISILNQLGVDFIVFGSECGDIDKLKETAKHLAFEEDDFKSSLKSYLKEGYSFPKARELALIKTCKTNIEFSSNNILGIEYIKWIYRLNSKIEPFTIRRIGASYNDPNLTQDTYASATAIRRNINNLHAIKNKMPSVSYEILLEEFESGRGPVILEDYFKLFIYNAIVVPDFLKNKIDVKEGLENRFEKYIFNSPSAKNLLENVKTKRYTLTRLQRIFIHAIVRNNFDQKALLSI...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
Q3A287
MRAVGLITEYNPFHNGHLHHLRASREAAGAEVAVAVMSGHFLQRGEPALLDKWRRAEMALRCGVDVVVELPFPFACASAPHFARGAVQCLDALGVDSLCFGSESGDLGALQRCAQLLEECGEQVAERTATLLRRGMHYAAARSQVCAELSGCDAATLPLHQPNNILGIEYLRALRATGSAMQPFTISRLGAGYHDDAVGPGNIASASGIRKRLAMGETVDELLPAPAVDVVAGARADRLFPDEDLLHRLLLAQIFRGRDYLQSLYQVESGIDARLTDAAATSRDWQALVDAVKVRQFTRTRIQRTLMYILNDVRGDLMAS...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
Q0AYW7
MAILGIVAEYNPFHNGHLYLLEKSRQQGDFSATVVVMSGNFLQRGEPAFCDKWARAEMALTAGVDLLIELPFCFATRSAYYFAKGAVQLLQRSGVVTHLAFGSESGQLSQLQEIAGILAHEPESYKTALKKRLSQGWSFPLARSSALQEYMGGEKKQLQEILPGPNNILALEYLRVIEEEGIPLLPLTIPRQGSSFHSSDLSPYSSARAIRQALYHNLDWEKITNSISPATEKILQREIALGRAPIGPDSLEQAIMVNLRLVSTDYLREIYEVSEGLEFRIKEATNSCGTLEELRQFIKSKRYSLTRINRTLLYTLFALS...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
B7IEZ2
MKVLGVVVEYNPFHNGHLYHLKSAKKLVKPDFTIAVMSGNFCQRGEPAIVNKFARAKMALLNGIDVVLEIPTVYALQDAGGFAFGSVGLMHKLGLVTDIVFGSESADISFLEKISKILYENSKEFDYLIKRELKKGLSYPNARKFALQKFLKTDLDTIKKLENSNDILGIEYIKAIFKYNSNIKYHVIKRVGAKYNEQNLSGKFSSATAIRNAIKFEKNIKEYVPESTYLILKDEFEKGRGPVFLENLEQFILSEFRLKARENLENIYGFSEGLDKRFIDSANISTNLKEFIENIKAKRFTFSRIRRLIFHAIFNFEKNY...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
A6LP38
MKVLGVIVEYNPFHNGHLYHLQQAKKIVSPDYVIAIMSGNFCQRGEPAIINKFARAEIALKNGIDVVFELPTVYALQDAGGFAFGAITLLDKLTVVTDVVFGSESADKNFITTVAKTLLENPDKFDNLLKIELKKGLSFPNARKFALKKFLNENEDFLKMIENSNDILGIEYVKSILKLKSKINYHLIKRIGAKYNDTELESKYSSATAIRNAIVRNNPFETYVPQTSYKVLKREFSYGRGPVSLENMEQFILTFLRLKHRKDFESIYSFTEGLDQRFIKAIKTSKKLSDFLEKVKTKRFTYSRIRRAIFHALFDFKKEY...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
Q9X1K1
MEYNPFHNGHLYHLTSARELVKPDYTIAVMSGNFCQRGEPAVIDKFARAEIALRMGVDVVLELPVVFATQDAGGFAFGAVCVLDATGVVTDVVFGSESNDIEFLQRVARILYEQPDEYQKFLHEELKKGYSFPNARKYALMRYFSMKGWNEEEVLKLEKSNDILGVEYIHSALKIGSNIRFHTIKRVGAEEKDTSFRGRFSSATAIRNLMREKRWEEVRDSLPEDSFEILMREINEGRGPVFLENMGDFLLSFFRLKNMDFFEKIHGFSEGLEKRFHVCARQTGSYRDFLECVKAKRFTFSRIRRLALFSVFEVNKEFVE...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Catalytic Activity: acetate + ATP + cytidine...
Q9YBQ6
MDVELEVSGFIQRLRHSRLRGLLVVGTGDVKAWAEKLAGYAGGDCALVSPSAGRLPGICRSWAPPGSIERILGGEYAAAIIAVPGLLRPSIIAGAGETVRSGGFLAIVADPPDRWDPGPPRGTGLYREYLFSAIRDNPVHLWIDDESGRIVSESFLEYTGVGAQGWSPGRYKPSPGSGVPRRLVSACRSESQARALESLARFFRGRWRSALVRGDRGRGKSYVIGLALAYAAWRRLIGRAVLVGPTPLSVQSVMAGLLRGLDVLGLKGHRVVRTSGGEVIRVSGPWFRIAYEQPDTAEPSPLVVVDEAAAVGVARVRRLS...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
P76562
MAELTALHTLTAQMKREGIRRLLVLSGEEGWCFEHTLKLRDALPGDWLWISPRPDAENHCSPSALQTLLGREFRHAVFDARHGFDAAAFAALSGTLKAGSWLVLLLPVWEEWENQPDADSLRWSDCPDPIATPHFVQHLKRVLTADNEAILWRQNQPFSLAHFTPRTDWYPATGAPQPEQQQLLKQLMTMPPGVAAVTAARGRGKSALAGQLISRIAGRAIVTAPAKASTDVLAQFAGEKFRFIAPDALLASDEQADWLVVDEAAAIPAPLLHQLVSRFPRTLLTTTVQGYEGTGRGFLLKFCARFPHLHRFELQQPIRW...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). It recognizes the wobble base of tRNA(Met), thus distinguishing between tRNA(Met) and the structurally similar tRNA(Ile2) . Could use an RNA helicase motor driv...
Q7VLN6
MRQLVILSTMPPIQGGVLLNSQNFSKAKQFLGQEYPFALYDMRSENGICFNLEAFAIIVGTIQENGTLYLICPNWHSVEQQIDVDAIRWNGGVAIACPHFFQHFKRLINKFGFEVTSRPQQPFIKTAPSYPAKLIQFTDEQQNILQKLPLDPAEIHIITAARGRGKSTLAGKLAEQFAKTEQVILTAHRSSSIQKILQTASINIPFFAPDKLLNLIETKQISADHLLFIDEAACIPLPILQQLGNYFKKVILTTTTQNYEGTGRGFKLKLVKQLHRTTKEWQLFQPLRWSNHDRLEQFTNELLLLNDELIPLDQNSQFYH...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
P44140
MPSRQLQILIRKTLPLVPDHVLIIGESGIAFSKATNLLGQEFEHILFDGRNGIHLEALAIAAGTLKMGGTLCLVLSDWENLSQQPDQDSLRWNGNQSAIATPNFIYHFKQCIERYHFPILREESAVEFPTVFYSNEHHKNATLAQQQIIENILQAEQDIYFLTAKRGRGKSALLGMLANQIQAPVYLTAPNKSAVHSVIEFSEGDIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPLPLLQEYSRYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEHFIDDLLLLNAEDDFQHFDYS...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
D4GW73
MTELGDDPDVEALAAARREEALATNQRRLLVLAGDRDAGIDAAFDAVRGADVPDDEVTFVTAREGFRFHRVEPKRASSLLGTTRTLVVLDAHEEFSANALGRVAGAVDGGGLLVLLTPSLDDWPTRRDSFDERLAVPPFSVADVTGRFRGRLVSTLRDHPGVALVDLDSGTVERDGAYRQGISFDAAPPRVPTEKDRRSPRRAYEDCLTADQSEALAALEALTEPGTAVVVEADRGRGKSSAAGLAAGSLAAEGKDVVVTAPGERNAAEVFARAERLLSELGALRGGGAGDFDIAADRGGRVRYVPPTEAGDAAADADAL...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
Q5QY69
MAERSGYRQLQLLQDASLWREYCEARSESSIYLSNLQTHADAVLSRYRDYLGHEFEQVWIDCHDGLHADAIAALCGTVTAGGLLSILLPAESNAMSHRMERFAAKHFAESNIKPYSSVNKTETRSANETLQLTNEQNSIFNALTQSTAKPYETHIITAERGRGKSTLLGQALAQAKEHRSIIVTAPRKANAKVLLQQAPEAHFVAWDKLLEQPGNSEVTLIIDEAAGLPLWATEQLCQKFNPWLLATTVAGYEGCGRGFAVHFTDWARKTLPQVSVHQLTQPLRWPANDPLEQWLTETFLLNEQPVTQFGNRESGTFIKH...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
Q8TYZ5
MPDKAEVFFDEGVLDFADVDEIVLDVGEEALAEALAHRHRRMIVFQGDEGKAEAAGVVTAGAADVLFDVRDRPISVLYVTDSLKEDTYARERYEEFRRVLEGFAEEANFEYELEALTFSGSKRALGTTWDLMVIDLSYDLDPDAIGRLVETVRGGGLVIFQTPPFDRWRNMWTAFHKSLVTPPYTLDHVGKRFNRRFIRKLKEHDGVWIVDTDEWTAEPEPSEDVDLEVEVKRRERPDLDPPDDAVLPEELYRMCATEDQFRALIRFEELLESNGKTALILTADRGRGKSALLGIAVAGAGVTTDVYDVVVTASEPENVA...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
D5C1K8
MHPILFPPTLDNIRKITASLVAAAKASGHRRALVLSGDREWCLQAAQVSLASTSLEPVLWIAAQAPENAWRMEAAKAHRSLGQEVDAIVFDAYSGFDLDAFGIITGAIRGGGLLLLLTPPLAAWPSFNDPEHARIVTAPYEVTEVTGRFLKRLVRILREAEGVIIIEQGKILPSVPFAAPARAETGGNPPSPGDSACRTEDQGRAVEAIVKVVTGQRRRPVVLTSDRGRGKSAALGIAAARLLQRGLKHIIVTGPRLDAVEPVFRHAQRLLPQATVSRAALHLPEAGMEFAPPDDLIRTSRPADLLLVDEAATIPTPLLE...
Function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). Catalytic Activity: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate...
Q86X19
MELPDPVRQRLGNFSRAVFSDSNRTGPESNEGPENEMVSSLALQMSLYFNTYYFPLWWVSSIMMLHMKYSILPDYYKFIVITVIILITLIEAIRLYLGYVGNLQEKVPELAGFWLLSLLLQLPLILFLLFNEGLTNLPLEKAIHIIFTLFLAFQVVAAFLTLRKMVNQLAVRFHLQDFDRLSANRGDMRRMRSCIEEI
Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Locati...
Q8K0U3
MELPDPVRQRLSNLSLTVFGDSSRTGPESSDAADNEMVSSLALQMSLYFNSYFFPLWWVSCIVMLHLKYSILPDYYKFIVVTVVILITLIEAIRLYLGCMGNLQEKVPELAGFWLLSLLLQLPLILFLLLNDGLRNLPLEKAIHIIFTIFLTFQVISAFLTLKKMVNQLAARFHLQDFDQLSSSSAAVRRVRQCTEEL
Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. Location Topology: Mul...
Q5HZE5
MELPDPVRQRLSNLSLTMFGDSSRTGPESSEAADNEMVSSLPLQMSLYFNSYFFPLWWVSCIVMLHLKYSVLPDYYKFIVITVVILITLIEAIRLYLGCMGNLQEKVPELAGFWLLSLLLQLPLLLFLLLNEGLKNLPLEKAIHSIFTVFLTFQVISAFLTLKKMVNQLAARFHLQDFDQLSASSATGRRARQSSEEL
Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Locati...
Q3SZ36
MPSAFSVSRFPVSIPAVITQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE
Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity). Location Topology: Multi-pass membrane...
Q96B42
MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCLSSRSYRLQIGHFLCLVILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLLVNAMIIVVMWVWKTLNVMTDLKNAQERRKEKKRRRKED
Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). Location Topology: Multi-pass membrane protein Sequenc...
Q3TUD9
MSSAYSVRSFPVSIPAVIMETDWTEPWLLGLLAFHLLCLLLTCFSSQRYKLQIGHFLCLVVLVYSAEYINEVAAVNWRLFSKYQYFDSRGMFISLVFSAPLLFNAMLIVIMWVRKTLTVMTDLKTLQEERKERRRRRKEE
Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity). Location Topology: Multi-pass membrane...
Q6DGF8
MASPYSVRVFPVSIPAVIMETDWTEPWLLGLLAFHLLCLLLTCFSAQRYKLQIGHFLCLVVLVYCAEYINEVAAMNWRLFAKYQYFDSRGMFISLVFSAPLLFNAMVIVIMWVRKTLTVMSDLKNLQERRKERKRRRKEE
Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats (By similarity). Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). Location Topology: Multi-pass membrane...
Q86YD3
MALPPGPAALRHTLLLLPALLSSGWGELEPQIDGQTWAERALRENERHAFTCRVAGGPGTPRLAWYLDGQLQEASTSRLLSVGGEAFSGGTSTFTVTAHRAQHELNCSLQDPRSGRSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTSASLPAPGLLATRVEVPLLGIVVAAGLALGTLVGFSTLVACLVCRKEKKTKGPSRHPSLISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDSRAVKPADRQ...
Function: In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 39285 Sequence Length: 366 Subcellular Location: Cell membrane
Q9DCF1
MELPLSQATLRHTLLLLPALLSSGQGELAPQIDGQTWAERALRENEHHAFTCRVAGGSATPRLAWYLDGQLQEATTSRLLSVGGDAFSGGTSTFTVTAQRSQHELNCSLQDPGSGRPANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQDGPVTVNASDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTSASLPAPGLLATRIEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDLRGKATERPM...
Function: In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 39170 Sequence Length: 365 Subcellular Location: Late endosome
A6H773
MLFLALGGPWAAGLRLSGKRTALWASSALRDPRAAVSRAASCRGSSGRVGGTGLSAAAPVLRRVRAQIPVCWERGVRCSHTQLDKSEDGRLIYTGNLARTVFGVKCFSYSTSLISLAFLPYIFAQNNVIFGSLPLQILFYGTIGSFTVITPALLHFLTKGYVIRLYHEARTDTYKAITYSVVLSEKSTVFHQNDVKIPNSTHVFTTFYAKTKSLLVNPALFPNPEDYNHLMGYDKPFTFDLEEASEKKQLKEEK
Function: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction. Therefore, participates in the early stage of mitochondrial ATP synthase ...
Q5ZLJ4
MLLRAAGCWRAAASRPGPVWLRGAEHRGLPLASRRLGLPLPLPLAAGGRRLRSGCGALPEVASFQGVAVRSLSTSAPSDHPEHGRLVYKGNLAKAVLGVRFFSYSTSIFNLFMAPYLMLKTGIGFDSLFLQAAFYGLIGFFTFVTPVTLHILTKGYVIRLYYKEEMDTYTAITYNAILAEKATVFHQKDVKIPDITKMFTTFYAKTKSMLVNPTLFPDPQDYNRLMGYDKAFCFDFEEEEKDGESK
Function: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1. Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also prot...
Q9BUB7
MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK
Function: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction . Therefore, participates in the early stage of mitochondrial ATP synthase...
Q921N7
MLLGLGGRWAAGLWPGRTRTTWCVAAALRGSGIAFWRAASLAEPERLRSGGHLALAESCGPPGRAQIPVCWEQCVRCFHTQVDKPENGRLIYTGNLARTIFGVKCFSYSTSVVSLAFLPYLLSQNNMMFGSLPLQVLFYGVMGSFTVITPTLLHLLTKGYVIRLYHEATSDTYRAVTYNVMLSETSTVFHQDDVTIPESAHIFTSFYAKTKSLLVNPALFLNPEDYNHLMGYDKPFTFDMEEVDEKKLHEGEK
Function: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (By similarity). Therefore, participates in the early stage of mitochondri...
Q96NL1
MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS
Function: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 33338 Sequence Length: 305 Subcellular Location: Lysosome membrane
Q9BSE2
MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIEGAEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQPQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALILFPCLLYGAYAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIHRRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLF...
Function: Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43520 Sequence Length: 394 Subcellular Loca...
Q96JJ7
MAAWKSWTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYF...
Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. PTM: N-glycosylated. Location Topology: Single-pass membrane protein Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Sequence Mass (Da): 51872 Seque...
Q8BXZ1
MANAVGRRSWAALRLCAAVILLDLAVCKGFVEDLNESFKDNRKDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFDHVRKRHRVFFVYIGGESPLKEKYIDAASELIVYTYFFSASEDVVPEYVTLKEMPAVLVFKDDTYFVYDEYEDGDLSSWISRERFQNYLTMDGFLLYELGDTGKLVAIAVIDEKNTSLEHTRLKSIIQEVARDFRDHFHRDFQFGHMDGNDYINTLLMDELTVPTIVVLNTSNQ...
Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (By similarity). PTM: N-glycosylated. Location Topology: Single-pass membrane protein Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Sequence Mass (...
Q6GNG3
MAAAGLCFILAIVSSTSLLASVPVSALVEDLDDSFKENRKDDIWLVDFYAPWCGHCKKLEPVWNEVGIEIRTSGSPIRVGKIDATVYSSIASEFGVRGFPTIKALKGDMAYNYRGPRTKEDIVEFANRVAGPLIRPLPSQQMFDHVKKRHPVLFVYVGVESTLKEKFIEVASELIVYTYFFSASEDVLPKYVTLNEVPAVLVFKDSTYFVYDEYEDGDLSSWVNKERFEGYLHIDGFTLYELGDTGKLVAVAVIDEKNNSIEHTRIKSIAQDVAKNNRNNFHRDFQFGHMDGNDYINSLLMDELSIPTFVVLNTSNQQYF...
Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Location Topology: Single-pass membrane protein Sequence Mass (Da): 50861 Sequence Length: 452 Domain: The di-lysine motif confers...
Q9Y275
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes th...
Q9WU72
MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICRDGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELTAGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNGMNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIARLEEGDEIQLAIPRENAQISRNGDDTFFGALKLL
Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes th...
Q46731
MITSALHRAADWAKSVFSSAALGDPRRTARLVNVAAQLAKYSGKSITISSEGSEAMQEGAYRFIRNPNVSAEAIRKAGAMQTVKLAQEFPELLAIEDTTSLSYRHQVAEELGKLGSIQDKSRGWWVHSVLLLEATTFRTVGLLHQEWWMRPDDPADADEKESGKWLAAAATSRLRMGSMMSNVIAVCDREADIHAYLQDKLAHNERFVVRSKHPRKDVESGLYLYDHLKNQPELGGYQISIPQKGVVDKRGKRKNRPARKASLSLRSGRITLKQGNITLNAVLAEEINPPKGETPLKWLLLTSEPVESLAQALRVIDIYT...
Cofactor: Binds 2 magnesium ions per subunit. Function: Mediates transposition of transposon Tn5 by a 'cut and paste' mechanism. First, the monomeric transposase binds the 19 bp inverted DNA repeats flanking the transposon. Then, dimerization of the DNA-bound transposase creates a synaptic DNA complex. After nicking of...
P53322
MSNKFTMESPKHLVDDVLFISPTNDGSEEKPTEVTFQEDEGHDASLHNRSHDKKSELATEREIMATTTDDDGIPSPSHPMEKRVLRKMDIYLIPLMGMLYFLSNLDKSNIGNAEVAGLSKDIHLVGTQYNTCVTVFFATYVLFDPIGTNLLKIMGPPLMMSICLTCFGAISLGTAWVKNYAQLIVVRLLLGAFEGMIYPAINMYLSVCYRREQYALRFAFVFSAACLSSSFGGLIAYGCSKISGSLKDWQYIYIVEGCISLGFVPFYAFGLSKNLEDSWFFNKEEKEYISERYKTMNTFDPDEKFEWFQVWQAVKDVKTW...
Function: Involved in the uptake of nicotinic acid. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60135 Sequence Length: 534 Subcellular Location: Membrane
P31015
MPKGEPFKIKMVEPIRLIPREDREAAIKAAHYNPFLLRSSDVYIDLLTDSGTGAMSQFQWSAMMLGDESYAGASSYYRLKEAVTDITGYEYVLPTHQGRGAEKSAFAQLITRPGMYVLSNMFFDTTRGHVQLAGGRPIDLLLDVPTEEYHPFKGNMDTARLEAFIQEHGAENIACIVMTVTNNSAGGQPVSMANIRETSRIARKYGILLLFDVARYAENCHFIRMREEGYADKAPIDIAREMFSYGDGLMMSAKKDALVNIGGLLAFKDEELYTRVGGTVVPFEGFLTYGGLAGRDLEAMAVGLREALDPDYLAYRVGQV...
Catalytic Activity: H2O + L-tryptophan = indole + NH4(+) + pyruvate Sequence Mass (Da): 50661 Sequence Length: 454 Pathway: Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1. EC: 4.1.99.1
Q894M8
MIIYYLKLEGFNMKIKYVAEPFRIKMVEPIKMLTREERELKIAEAKYNTFNLRGEDVYIDLLTDSGTNAMSDDQWAGVMKGDEAYAGGKSYFKLVDAVKDIFGYKFVQPVHQGRAAEKVLFGLLLGEGKYSISNMHFDTTRAHVELSGARAIDCVVPEASDPTVRIPFKGNMDVEKLEKLIKEHGADKIGVVVMTITNNSAGGQPVSIENMKETAEICKKYNIRLCIDAARYAENAYFIKQREPGYENKSIKEIIKEIFSYADIFTMSAKKDAIVNMGGLLGIKEDEELFQLCKGRTISFEGFITYGGLSGRDLESLAIG...
Catalytic Activity: H2O + L-tryptophan = indole + NH4(+) + pyruvate Sequence Mass (Da): 53131 Sequence Length: 472 Pathway: Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1. EC: 4.1.99.1
Q7TQP6
MGNYKSRPTQTCSDEWKKKVSESYAIIIERLEDNLQIKENEFQELRHIFGSDEAFSEVSLNYRTERGLSLLHLCCVCGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVYKDSPELITSLLHSGADVQQVGYGGLTALHIAAIAGHPEAAEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEEGSKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFEVAKEIVQVTGTESLTKENIFSETAFHSACTYGKNID...
Function: May play a role in cardiac physiology. PTM: Autophosphorylated. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 92732 Sequence Length: 835 Subcellular Location: Nucleus EC: 2.7.11.1
Q15025
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQW...
Function: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG . Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear tran...
Q9WUU8
MEGRGPYRIYDPGGSTPLGEVSAAFERLVEENTRLKGKMQGIKMLGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPATSTAATTTATATTGNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDLGPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQPSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLE...
Function: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (By similarity). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAP...
Q8NFZ5
MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERA...
Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling ...
Q99JG7
MSSGDPRSGRQDGAPRAAAALCGLYHEAGQQLQRLKDQLAARDALIASLRTRLAALEGHTAPSLVDALLDQVERFREQLRRQEEGASETQLRQEVERLTERLEEKEREMQQLMSQPQHEQEKEVVLLRRSVAEKEKARAASDVLCRSLADETHQLRRTLAATAHMCQHLAKCLDERQCAQGDAGEKSPAELEQTSSDASGQSVIKKLQEENRLLKQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKRRQVPLEPELMKKEISRLNRQLEEKISDCAEANQELTAMRMSRDTALERVQMLEQQILAYKDDFKSERADRER...
Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling ...
Q13470
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGG...
Function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could sp...
Q9H2S6
MAKNPPENCEDCHILNAEAFKSKKICKSLKICGLVFGILALTLIVLFWGSKHFWPEVPKKAYDMEHTFYSNGEKKKIYMEIDPVTRTEIFRSGNGTDETLEVHDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAEKPIENRDFLKNSKILEICDNVTMYWINPTLISVSELQDFEEEGEDLHFPANEKKGIEQNEQWVVPQVKVEKTRHARQASEEELPINDYTENGIEFDPMLDERGYCCIYCRRGNRYCRRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV
Function: May be an angiogenesis inhibitor. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 37130 Sequence Length: 317 Subcellular Location: Membrane
Q8NFQ8
MADSGLREPQEDSQKDLENDPSVNSQAQETTIIASNAEEAEILHSACGLSKDHQEVETEGPESADTGDKSESPDEANVGKHPKDKTEDENKQSFLDGGKGHHLPSENLGKEPLDPDPSHSPSDKVGRADAHLGSSSVALPKEASDGTGASQEPPTTDSQEAQSPGHSSAGQEGEDTLRRRLLAPEAGSHPQQTQKLEEIKENAQDTMRQINKKGFWSYGPVILVVLVVAVVASSVNSYYSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASNPTEPATIIFTAAREGRETLKCLSHHVADAYT...
Function: Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 51263 Sequence Length: 470 Subcellular Loc...
Q6P752
MSQTLKSQDTNMSDSGYRDPVEDSQNVLGNDPSVNSQAQDPIVTPSNTVEAQTLHPTSDLKEDHHEIGAKGQEHADTGDRAESSEEPALEKPPLDKAELERSPSSQDTEQRHHPYSEHVGGDTLVLDPNYSQSDLGGRADAHLESSSAAPTEGAGEGGEAGAHLESSCAALPVGADEGGRANAHLESSSAAPTEGAGEGGEADVHLESSSAVPPEEAHLESSSAAPSEGAGEGGEADAHLESSSAAPSEGAGEGGETAQNLLAVDSTDAQSPCHSSAGPGSQDSLRRRLPVTEAERHEEETQLVTEKEEVAQETLRKTEK...
Function: Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity). Location Topology: Single-pass membrane protein Sequence Mass (Da): 61698 Sequence Length: 578...
Q6INE3
MATSISTQRGQVFIGELPQDFLRISPTQQQQQIQLDAQAAQQLQYSGVMATMGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTIPPGVDSFYIEIFDERAFSMDDRIAWTHITIPETLKEGKHVDEWFSLSGKQGDDKEGMINLVMSYTSVPAMMPAQPVVLMPTVYQQGVGYVPIADPIYNPGMPMAAPPPAVNPQHETREEDIQSIKDMFPTMDPEVIRSVLEAQGGNRDAAVNSLLQMVEDS
Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective auto...
P40310
MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGVLAEELKDALRFRDERVSIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVVEKWRSLKNNSVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHFSKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIGYKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVF...
Function: Outwardly rectifying potassium channel. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 77408 Sequence Length: 691 Subcellular Location: Cell membrane
Q9LFL3
MGDNLMDKVTAFGERLKIGGSEVSNKISAGVSSMSFKVKELFQGPNPTDKIVEDATTENLEEPDWDMNLEICDMINQETINSVELIRGIKKRIMMKQPRIQYLALVLLETCVKNCEKAFSEVAAERVLDEMVKLIDDPQTVVNNRNKALMLIEAWGESTSELRYLPVFEETYKSLKARGIRFPGRDNESLAPIFTPARSTPAPELNADLPQHVHEPAHIQYDVPVRSFTAEQTKEAFDIARNSIELLSTVLSSSPQHDALQDDLTTTLVQQCRQSQTTVQRIIETAGENEALLFEALNVNDELVKTLSKYEEMNKPSAPL...
Function: Might contribute to the loading of the ESCRT machinery. Location Topology: Peripheral membrane protein Sequence Mass (Da): 45311 Sequence Length: 407 Subcellular Location: Membrane
Q9LNC6
MDKLKIAEWGEKLKTGGAQMSRMVSEKVKDMLQAPTLESKMVDEATLETLEEPNWGMNMRICAQINNDEFNGTEIVRAIKRKISGKSPVSQRLSLELLEACAMNCEKVFSEVASEKVLDEMVWLIKNGEADSENRKRAFQLIRAWGQSQDLTYLPVFHQTYMSLEGENGLHARGEENSMPGQSSLESLMQRPVPVPPPGSYPVPNQEQALGDDDGLDYNFGNLSIKDKKEQIEITRNSLELLSSMLNTEGKPNHTEDDLTVSLMEKCKQSQPLIQMIIESTTDDEGVLFEALHLNDELQQVLSSYKKPDETEKKASIVEQ...
Function: Binds ubiquitin in vitro . Might contribute to the loading of the ESCRT machinery (Probable). Location Topology: Peripheral membrane protein Sequence Mass (Da): 42797 Sequence Length: 383 Subcellular Location: Cytoplasm
Q6NQK0
MANDAAACAERATNDMLIGPDWAINIELCDLINMDPSQAKEAVKVLKKRLGSKNSKVQILALYALETLSKNCGENVYQLIIDRGLLNDMVKIVKKKPELNVREKILTLLDTWQEAFGGRGGRYPQYYNAYNDLRSAGIEFPPRTESSLSFFTPPQTQPDEDAAIQASLQGDDASSLSLEEIQSAEGSVDVLMDMLGAHDPGNPESLKEEVIVDLVEQCRTYQRRVMTLVNTTTDEELLCQGLALNDNLQHVLQRHDDIANVGSVPSNGRNTRAPPPVQIVDINHDDEDDESDDEFARLAHRSSTPTRRPVHGSDSGMVDI...
Function: Might contribute to the loading of the ESCRT machinery. Location Topology: Peripheral membrane protein Sequence Mass (Da): 49255 Sequence Length: 446 Subcellular Location: Cytoplasm
Q9FFQ0
MAAELVSSATSEKLADVDWAKNIEICELAARDERQAKDVIKAIKKRLGSKNPNTQLYAVQLLEMLMNNIGENIHKQVIDTGVLPTLVKIVKKKSDLPVRERIFLLLDATQTSLGGASGKFPQYYTAYYELVNAGVKFTQRPNATPVVVTAQAVPRNTLNEQLASARNEGPATTQQRESQSVSPSSILQKASTALEILKEVLDAVDSQNPEGAKDEFTLDLVEQCSFQKERVMHLVMTSRDEKAVSKAIELNEQLQRILNRHEDLLSGRITVPSRSTTSNGYHSNLEPVRPISNGDQKRELKASNANTESSSFISNRAHLK...
Function: Might contribute to the loading of the ESCRT machinery. Location Topology: Peripheral membrane protein Sequence Mass (Da): 49423 Sequence Length: 447 Subcellular Location: Cytoplasm
O80910
MASSSASATVAVDKATSDLLLGPDWTTNMEICDSVNSLHWQAKDVVKAVKKRLQHKSSRVQLLALTLLETLVKNCGDYLHHQVAEKNILGEMVKIVKKKADMQVRDKILVMVDSWQQAFGGPEGKYPQYYWAYDELRRSGVEFPRRSPDASPIITPPVSHPPLRQPQGGYGVPPAGYGVHQAGYGVPQAGYGIPQAGYGVPQAGYGIPQVGYGMPSGSSRRLDEAMATEVEGLSLSSIESMRDVMDLLGDMLQAVDPSDREAVKDEVIVDLVERCRSNQKKLMQMLTSTGDDELLGRGLDLNDSLQILLAKHDAIASGSP...
Function: Acts as a gatekeeper for degradative protein sorting to the vacuole. Plays a role in recognition of ubiquitinated PIN2 auxin carrier at the plasma membrane and further to its endocytic sorting. Binds ubiquitin in vitro . Might contribute to the loading of the ESCRT machinery (Probable). Location Topology: Per...
F4KAU9
MRPSCASSSSSSASPSLRLSSVTVAVDKATSELLRTPDWTIIIAICDSLNSNRWQCKDAIKAVKRRLQHKSSRVQLLTLTLLEAMLKNCGDFVHSHIAEKHLLEDMVKLVRKKGDFEVRNKLLILLDTWNEAFSGVACKHPHYNWAYQELKRCGVKFPQRSKEAPLMLEPPPPVTQSSSSSSMNLMSIGSFRRLDETMATEIESLSLSSLESMRNVMDLVNDMVQAVNPSDKSALKDELIVDLVEQCRSNQKKLIQMLTTTADEDVLARGLELNDSLQVVLARHDAIASGVSLPLLLQAPEPRETSSSLKTCGAAALESA...
Function: Might contribute to the loading of the ESCRT machinery. Location Topology: Peripheral membrane protein Sequence Mass (Da): 59768 Sequence Length: 542 Subcellular Location: Membrane
Q9C9Y1
MVHPLVDRATSDMLIGPDWAMNLEICDMLNHEPGQTREVVSGIKKRLTSRTSKVQLLALTLLETIITNCGELIHMQVAEKDILHKMVKMAKRKPNIQVKEKILILIDTWQESFSGPQGRHPQYYAAYQELLRAGIVFPQRPQITPSSGQNGPSTRYPQNSRNARQEAIDTSTESEFPTLSLTEIQNARGIMDVLAEMMNAIDGNNKEGLKQEVVVDLVSQCRTYKQRVVHLVNSTSDESMLCQGLALNDDLQRLLAKHEAIASGNSMIKKEEKSKKEVPKDTTQIIDVGSSETKNGSVVAYTTNGPKIDLLSGDDFETPN...
Function: Might contribute to the loading of the ESCRT machinery. Location Topology: Peripheral membrane protein Sequence Mass (Da): 66686 Sequence Length: 607 Subcellular Location: Membrane
P43768
MTAELNFLDLFLKASIVVQLVIVILISFSIISWAIIIQRSRILTNALKEARTFEDRFWSGEDLNKLYEGLSNRRDGLTGSEQIFCVGFKEFSRLKQVNPDAPEAIIKGTMRAMNLAMNREIESLENRVPFLATVASVSPYIGLFGTVWGIMHAFMALSGAKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLSLRVNAIEQDYGNFIDEFTTILHRQAFGKAPH
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 25287 Sequence Length: 228 Subcellular Location: Cell inner membrane
P50598
MEPNVVDHTSMWSLISNASIVVQLVMLTLVAASVTSWIMIFQRGNAMRAAKKALDAFEERFWSGIDLSKLYRQAGSNPDPDSGVEQIFRAGFKEFSRLRQQPGVDPDAVMEGVARAMRVAISREEEKLEASLPFLATVGSTSPYVGLFGTVWGIMNSFRGLATVQQATLATVAPGIAEALIATAIGLFAAIPAVIAYNRFSARSEMLIGRYYTFADEFQAILHRKVHTSDD
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 25282 Sequence Length: 231 Subcellular Location: Cell inner membrane
P0ABV8
MARARGRGRRDLKSEINIVPLLDVLLVLLLIFMATAPIITQSVEVDLPDATESQAVSSNDNPPVIVEVSGIGQYTVVVEKDRLERLPPEQVVAEVSSRFKANPKTVFLIGGAKDVPYDEIIKALNLLHSAGVKSVGLMTQPI
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. Location Topology: Single-pass membrane prot...
P43769
MARRQRKAIKSEINIVPFLDVLLVLVLIFMATAPIISQSVQVELPDSVQSQEVSNEDKVPVILEVAGIGKYAISIGGERQEGLTEEMVTQLSRQEFDKDNNTLFLVGGAKEVPYEEVIKALNLLHLAGIKSVGLMTNPI
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 15258 Sequence Length: 139 Subcellular Location: Cell inner membrane
P50599
MARVRHKRKPVAEMNVVPYIDVMLVLLVIFMVTAPMLNQGVKVDLPKVSSEALPQDNNKQVLTLSVKADGSYYWNVGSEVDTEKQTDSAVSLEQMTDAVTKIMSARPDTQVFIRGDKAVNYGAVVGAMGALQQAGVPNVGLITEAP
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 15788 Sequence Length: 146 Subcellular Location: Cell inner membrane
P83588
SPVCTPSGQPCQPNTQPCCNNAEEEQTINCNGNTVYRCA
Function: Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav). PTM: Contains 3 disulfide bonds. Sequence Mass (Da): 4173 Sequence Length: 39 Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Subcellular Location: Secreted
Q9FEG2
MTDSGLMMPAEIAGILTTAITSWWDDVNESTQWQDGIFFALCGAYALVSAVALVQLIRIQMRVPEYGWTTQKVFHLMNFVVNGVRAVLFGFHMQVFLVHPKALCWVLLDLPGLLFFSAYTLLVLFWAEIYHQARSLPTDKLRITYISVNVAVYLAQIGIWAYIWVHDNSTVELVGKIFIAVVSFIAALGFLLYGGRLFFMLRRFPIESKGRRKKLHEVGSVTAICFTCFLIRCVVVAVSAFDKDLTLDVLDHPVLNLIYYMVVEVLPSALVLFILRKLPPKRVSAQYHPIQ
Function: Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 33009 Sequence Length: 291 Subcellular Location: Vacuole membrane
Q54GH3
MVTELVDKATNELLIQTDWTTVLQISDILNRDPIHARGVVRQVTKKLKDRSRVILLALELADSLLQNCHCTHVYFAERTFQTELCRLIMNKKTKLNVKEKTLEIVESWGNAFQARHDVPGFYETYSFIKRSGYKFPPKPSDAPILNFNNSPAKRTVSTTILTNNSHSTTPPQANVPSFNNVSSVGSNNAGGGGSSSQPIKNQEISSIKGSTSVFNEMISFLNVEDEDPQENDLIKELFETCKQSQIRVKEMIESGSTNERDLNVLLKLNDEINNALNDHEACIKRRRAFVENGYKPVPPPQQQQQQQQQQQQQQQQQQQQ...
Function: May contribute to the sorting of ubiquitinated proteins and transfer them for further sorting/trafficking processes to the endosomal multivesicular bodies (MVBs) pathway. Binds to phospholipids, such as phosphatidylinositol PtdIns(3)P and PtdIns(3,5)P2. These phospholipids are involved in the recruitment of t...
O60784
MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAPLPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPADLELLQELNRTCRAMQQRVLELIPQIANEQLTEELLIVNDNLNNVFLRHERFERFRTGQTTKAPSEAEPAA...
Function: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways . Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures . Together with MYO...
Q57815
MVKLPAISKKPREIAKQKIIELAKKMYEDLMKGKRPKITMPIRSLSNAMFDKEKGSFTLVGKEKARTLTVNQAKIFAQTTKMLEFAKQLLETDDFSTLREAYYVSKNWGEARFDDQQASNNVIEDLEAALGVLREHLGFIPEEDGSSVVGPLKIIEETPEGELVVDCTKLGTGAYNIPNDVTKLNLETDADFILAIETSGMFARLNAERFWDKHNCILVSLKGVPARATRRFIKRLHEEHDLPVLVFTDGDPYGYLNIYRTLKVGSGKAIHLADKLSIPAARLIGVTPQDIIDYDLPTHPLKEQDIKRIKDGLKNDDFVR...
Cofactor: Mg(2+) is directly coordinated by Glu-197 and Asp-249 as well as indirectly coordinated through 2 water molecules by Asp-251 . Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded...
Q8PUB7
MEGEKGSKTRKGDALAREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVYGDRESERSAKTVKGAFQLLKTTYATDFLINEHLARNRGSTLRELYYISEGWDYAKFKEQGESDRLIEDLEILTSLQREYFHMRPEEDGATMFGPIEITEQTKRGERNIHCQKDVGEGGYQIPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLKGQPARSTRRIIKRMNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKFLGLQPSDIVEYELSTDKLTEQDVSALRSELSDP...
Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Sequence Mass (Da): 42127 Sequence Length: 369 EC: 5.6.2.2
O27089
MNRREIAINKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSMGNVKQIKKIGQMLYTANFCKDLVAREKTATLRELYYISEGWEVDFADQQESNIVGEDLEVTLGMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGKSGYNISPTIDEVEFVDHDVERVIAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGDPWGFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLPTDPLKDVDVVRLKELLQDPRYRGDFWKTEIKKMLT...
Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Sequence Mass (Da): 40029 Sequence Length: 353 EC: 5.6.2.2
A2XFC1
MSEKKRRGGAGAGAASGSASKKPRVSTAASYAESLRSKLRPDASILATLRSLASACSKSKPAGSSSSSSSASKALAAEDDPAASYIVVADQDSASVTSRINRLVLAAARSILSGRGFSFAVPSRAASNQVYLPDLDRIVLVRRESARPFANVATARKATITARVLSLVHAVLRRGIHVTKRDLFYTDVKLFGDQAQSDAVLDDVSCMLGCTRSSLHVVASEKGVVVGRLTFADDGDRIDCTRMGVGGKAIPPNIDRVSGIESDALFILLVEKDAAFMRLAEDRFYNRFPCIILTAKGQPDVATRLFLRRLKVELKLPVLA...
Function: Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity (By similarity). May be involved in cell proliferation and stress tolerance. Catalytic Activity: ATP-dep...
O59209
MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEAKSGKNPYFDVPTRGLNNVYFDEESRLIRLGDRLSRRYFLNVAHARKFMQTLILMAYIKRLVSEGKHASLREAYYANKHTVPGTRENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKRGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLENVTEKLKGIPPDKKGGPTG...
Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Sequence Mass (Da): 44296 Sequence Length: 382 EC: 5.6.2.2
O05208
MSSEFISKVDKEARRKAANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDVIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRATRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMGDIFGNSRKKPYLSEAERKNY...
Function: Relaxes both positive and negative supercoils and exhibits a strong decatenase and unknotting activity; it cannot introduce DNA supercoils . ATP is absolutely required for DNA cleavage; the nonhydrolyzable analog AMP-PNP generates nicked or linear products from a supercoiled dsDNA substrate. Generates stagger...
Q9YE64
MSAVAKRTRRARARAEEAARPGSTGEKYREMSVAEFFAKNKELAGFANPTRALYQTIRELVENSLDATDAKGILPWIHISIRQIEGSEGRGGRPRYTVTVEDNGIGVPVTSMAMAFGKVLFSSKYVIRQTRGMYGLGVKAAILYGQMTAGTPVEVYSATKGSQYVYMMKLVIDVQRNEPRILERGEWNKRGSWHGTRVTLSLEGDWSRAKSKILEYIKRTAVIAPYAEIILETPDGEIYYFPRSTRKLPKPPRESKPHPHGVDIEQLKSMLRSTRASTLREFLVKEFQSIGDKTAQDFLEKYGLDPDLKPRELLKKGRDK...
Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Sequence Mass (Da): 64354 Sequence Length: 568 EC: 5.6.2.2
Q9C5V6
MAGDDLVETKKGSSKNSKDSNESKLKQKSPAEFFAENKNIAGFDNPGKSLYTTVRELVENALDSAESISELPEVEVTIEEIVKSKFNSMIGLIDRERVDTQLYDDYETEKARGKRLAKEARASEIQAKNLASGKKNKEPGVSKVLKARGEASYYKVTCKDNGKGMPHDDIPNMFGRVLSGTKYGLKQTRGKFGLGAKMALIWSKMSTGLPIEISSSMKSQNYVTFCRLDIDIHRNIPHIHLHEKKGNKEKWHGAEIQVVIEGNWTTYRSKILHYMRQMAVITPYAQFLFRFISETPEKNVTIKFTRRTDVMPPIPIETKH...
Function: Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. Involved in cell-elongation processes. Catalytic Activity: ATP-dependent break...
O29605
MSGKHREISVAEFFEKNKHILGYSNPAKAIITVVKEAVDNALDACEEAGILPDIFVRISKVDDHFKIVVEDNGPGIPREQIPKVFGKLLYGSRFHEIRQSRGQQGIGISAAVLYAQLTTGKPATVISKTPDEDRAKKVVLYINTKKNEPEIVEEGEEEWYLPSGTKIELEVAGNYVRERKQSVYEYLRETSVINPHAKITFVEPDGTINEFKRVTDDIPQPPKSIKPHPHGIELGTLMSMLKSTRATTLRRFLKEEFVRVGEKIADDVLRKAGFSGDETPQEMGRDDAAKLLNAFRQTDFLPPPTDCLSPIGEAMIAKSL...
Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Sequence Mass (Da): 67400 Sequence Length: 602 EC: 5.6.2.2
Q8N2E6
MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGSSWVVYGTNYRKAIFIFIRWLLKLGHHGRAPPRRSGALPPAPAAPRPALRAQRAGPAGPGAKG
Function: Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides. PTM: Amidation of salusin-alpha(29-Gly) by peptidylglycine alpha-amidating monooxygenase, PAM, converts Lys-2...
N4WQZ8
MVYNPTATFHKKTLTRMKTGLGSNGDILFIQTRALRDQLSSSFRFVYSNGPFFSDPGPGVLPVYKDAGPFRSWLRRPLQNRAQEPRLHMEAIRKCLEGTMKEDEQSGASGQWVGLMGFSQGARLAASVLFESQRRQNIQEKGGIVRGYEGDNIETKLWDQRWQFAVLFSGPAPLIAFCPENDHLSSQSTAEHDPMYRALDNVNCSGELHITKPTLHVIGVKDEWAPSQRELYEKYCSKESSTLVEWEGAHRIPIESSIVKDLCARILVMSKQADFVES
Function: Probable esterase; part of the Tox1A locus, one of the 2 loci that mediate the biosynthesis of T-toxin, a family of linear polyketides 37 to 45 carbons in length, of which the major component is 41 carbons, and which leads to high virulence to maize . One of the PKSs (PKS1 or PKS2) could synthesize a precurso...
Q00357
MDEQIVSASSNVKDGVEKQPVKDREDVDANVVPPHSTPSLPKISLISLFSIVMSLGAAAFLGALDATVVAVLTPTLAQEFHSVDAVAWYGAIYLLMSGTTQPLFGKLYNEFSPKWLFITCLIVLQLGSLVCALARNSPTFIVGRAVAGIGAGGILSGALNIVALIVPLHHRAAFTGMIGALECVALIIGPIIGGAIADNIGWRWCFWINLPIGAAVCAILLFFFHPPRSTYSASGVPRSYSEILGNLDYIGAGMIISSLVCLSLALQWGGTKYKWGDGRVVALLVVFGVLFLSASGHQYWKGEKALFPTRLLRQRGFLLS...
Function: MFS-type transporter; part of the diffuse TOX2 gene cluster that mediates the biosynthesis of the HC-toxin, cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid . HC-toxin is a determinant of specificity and virulence in the interaction be...
P11439
MHLTPHWIPLVASLGLLAGGSFASAAEEAFDLWNECAKACVLDLKDGVRSSRMSVDPAIADTNGQGVLHYSMVLEGGNDALKLAIDNALSITSDGLTIRLEGGVEPNKPVRYSYTRQARGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELLAKLARDATFFVRAHESNEMQPTLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTWEGKIYRVLAGNPAKHDLDIKPTVISHRLHFPEGGSLAALTAHQACHLPLETFTRHRQPRGWEQLEQCGYPVQRLV...
Function: An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis . Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38 . PTM: The 8 cysteines participate...
M2WKH6
MKAIKVNAGRTAAVQPARMPKLRDGYLLCKVHCVALNPADWKYLDFIGVQGVTLGADLSGVVEEIDPSCGAHFEKGDRIAAFVHGGNVSQPDDGAFAEYCLVKADLALKVPDAMSDEDAATLGVAVATCGQALYQGLELPLPGGAPYDGFLLVYGGSTSTGTLAIQYARLSGCKVIATASPHNWPLLKELGVEETFDYKDPDCAKKVRGIPICKAGYLTDGALIRAFTSDSLVLALDCIAEGDSAKICEDSISESKGGTICYLFQAKHSRADIVDKRVFAYTVFGEAFDKFGQSWPARAEDFARGKEFAALASQMLSDGQ...
Function: Oxidoreductase; part of the hps1-dma1 gene cluster that probably mediates the biosynthesis a derivative of cyclopiazonic acid (CPA) (Probable). The hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) nps1 might incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-termi...
O74205
MGTTSPNSEKRQITDINERRKLQNRVAQRKYRTRQKTRMKLAEAVLNDYTYIHPTLGTIQSKKKSPLTMECDRSSASYPDLSSYAEICSETRSETQATRARQLTSQRTCFRESVDNNQADSHAQLSRCLNRQEMFYGISGETEFSEGDTRDRVECIDPNLTRGWLDMDLRSGTPNSSTVVDCGLCTVGANSQPPTRTNVQEAIETLELFEPNDQRKTENLPREPCGSCPSSSHGYSPTSGNPSTLLLTPSESLMNSVIVTSDSPLLAADDKSPGDLVISEANTHGPKEDQFSPLMTAISLGRLDIARILLQSGAPLDIPD...
Function: Transcription factor, part of the diffuse TOX2 gene cluster that mediates the biosynthesis of the HC-toxin, cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid . HC-toxin is a determinant of specificity and virulence in the interaction be...
Q9Y885
MAIPLPAFYKWDVYDSKLNNVHGHVECRYTAQTGYWSDPCFVQSPFLSVHGLAPGLNYGQQVYEGIQARRTARNEILIFRPGASADRMAKSATAVSMPPVPYELFVRSVHMAVALNADYVPPHDFHGSMYIRPCQFGSSCQIGLQPPDEFIFCVFVQPHIALHGHGSLRALIAEDFDRAATRGTGHVKIGGNYAPVIRWTQSAKKEENGGWDVLLHVDSKTQTRIDEFSTSAFIGTKYAEEQNEPPQIILPESAAAIQSITSDSVAWLAKSFGWNIVKQPVTIDELASLSEVMAVGTAAGLVPVSCIRHNSTNRTFEFPS...
Function: Aminotransferase, part of the diffuse TOX2 gene cluster that mediates the biosynthesis of the HC-toxin, cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid . HC-toxin is a determinant of specificity and virulence in the interaction betwee...
Q9UW18
MSNMVLNGNIDKSDRNSILDILQSLENIAWGQPGSARCDFRSDVITRPSLRMLSAVLKTTLGDDVFREDLTTAHFEAHVAEISGREEGMFVITGTMANQLCLHALVSTRPCGILLSSESHAIHYEAGGSSMLSGAMLQPVQPSNGKYLRVEDLEEHAILTDDVHKCPTSIVSMENTAGGAVVPVHELRRIRDWAKQNNVRTHLDGARLFEAVATGAGTLKEYCSLIDLVSVDFSKNLGAPMGAMILGDKKLIQQMRRTRKGIGGGMRQGGVITAAAREALFENFGLGAEIESQTLLQVHKVAKRLGEEWTRKGGKLSKEI...
Function: Alanine racemase, part of the diffuse TOX2 gene cluster that mediates the biosynthesis of the HC-toxin, cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid . HC-toxin is a determinant of specificity and virulence in the interaction betwee...
Q4WQZ7
MERQPKSLCDATQLLETANIISDTVQTIIAEWSAEAKAPQGSGKQNAPMLPSRELFDAQRTILAAVGKLTELVSDPSARILEVATQFQESRSLYIAAERRIPDLLAAGDEGGVHIDQISQKAKIEPRKLARILRYLCSIGIFKQTGPDTFANNRISAALVSNEPLRAYVQLVNSEGFTASDRLPHTLLHPDTGPSYDVAKTAWQNAVCTKKTRWEWLEERVAPEQLLESGGHYPGIPSLVMGLPPREDDGLVARPELEIMGLSMVGGGRVFGTAHVYDFPWASLGDALVVDVGGGVGGFPLQLSKVYPQLRFIVQDRGPV...
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process . The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC . The atrochrysone carboxyl...
M2U578
MEQLSYQSKLICSDESRHTGCFTTLPIRIHPRDDLADAASRRFVQDWAREMRDGREQSTHFSFSPVGNWSSLIYPEAIPERLGVLAYLSDLGLIHDDGGEGLSIEDAQAEHGELCAALDPSDISSAAPGSRAMKTKKLVSQCMLECISLDRELGLKMLAAFRDVWLAISERNSDKEAQTMEEYLKYRSDNGGMLVFWPMLQFSLGMSISEAEEALVQPIIDAATEGLLLANDYFSWEREYRELQSGQSKRIVSAVDLFIRTKGLSIDDAKEEVKRKIIAAERDFCQRRDDLYTNHPNIPLKLKRWIDCAGLAVSGNHYWC...
Function: Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of terpestacin . The bifunctional terpene synthase tpcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene preterpestacin I . The C-terminal prenyltransferase (PT) domain of ...
Q4WQZ6
MLALHQTQRDVPCSEVHDALGLQGARSIYFGRPTGRSILSDPIRPRPMPTVTVIIYSDIRFLLEFPSVFLCAYVLPVQRTVIMANEKRGGYRQINQALNICAWEGYLNEQHARLPTLEDVEQISPRVLRVLGQNEGKVRRADGYYTCSSRLIEGPQFTLQGTNTYIVGTGRHRLLIDTGQGIPEWASLISSTLAGSSIELSHVLLTHWHGDHTGGVPDLLRMYPDLSDSIYKHTPGKGQKPISDGQTFRVEGATVRAVHTPGHSHDHMCFILEEENAMFTGDNVLGHGSSAVEVLSTWMSSLRMMQSLRCAVGYPAHGAV...
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: Atrochrysone carboxyl ACP thioesterase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process . The pathway begins with the synthesis of atrochrysone thioester by ...
M2V0Z8
MAVISLLQGLSVGQQIGTAAAISVFVLTSIVVYGCYLHPLSHVPGPFLAKFSPIWGMRALYRMKFNSELQALHEKYGPVVRVAPNEVSFATLEAETAIYANQEDGRFSKAGTFLTLFSDLVLNAPTLITIPDPALHKRLHKVIQQAFTPQALASQEPIQKLHIEKAIPDFDETADKGYHIDLADKLETMFWEIIGDLAFGEPLMAGKRPTYEKLKQLGKGSMPMVEALSFMLVMPGVAPTLEMARSFLSAMPMSSQLSKLVPSTKLRDCVERKDGREDFLSAIMGSEKQGLTLDADAFFSNAMGLTLAGYQTTATTLAST...
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of terpestacin . The bifunctional terpene synthase tpcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene preterpestacin I . The C-terminal prenyltransferase (PT) domain of ...
M2UJ60
MAILSSALVTIDLPVTLVSLLVGSIFYFCYLTVYRLFLSPIAHFPGPKLAAWTYWYEFWYDVIAEPEYTFKIGRLHKIYGPVVRINPDEIHIADPDFYDTIYAGSGRKRDKWDWITRSFGVDESLIGTLKHDEHRVRRASLSPYFSKQSVRALQPLIDRNMAILLDRLREFAKSGSPLKLDDAYAALTNDIVEDYAFGRSDHRLEAPDFDPSFRDAMLQGGKAGHVLKHFTWLMDLLKKLPDSLLLKLSPAMGAYSQLQTSVKRQVAEIQHAHQMHTYDKTRRTIFHEILNSKLSDYDKSTDRLWQEGEVVVAAGTITTA...
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of terpestacin . The bifunctional terpene synthase tpcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene preterpestacin I . The C-terminal prenyltransferase (PT) domain of ...
M2T7Z1
MQLLGTLSWLYAIQASIGSSKAVTADYGSCHDACTLLSGTLSVELGGSHVSDYKHYPTIANGSSVASLFWAQQQQSAQPACLVHVYSPQDVATVISVSRSTNCPFAVRGGGHSDIPGASNINGGITVNMAALSNVELHESEGLARVGAGARWGDVYKELEKSNKTVVGGRLTGVGVGGLVLGGGLSHFSGLHGWACDNVRNYEVVLANGTLVIASNSSNPDLYRALRGGGNSFGVVTRFDLDVFQQGPMWGGLHVWPFQPSVTSAITRGFVEFAHNAPSDPHVSLFAGLGYKQGGFAWAVGQYDALGRVEPPIFTQFKDD...
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of terpestacin . The bifunctional terpene synthase tpcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene preterpestacin I . The C-terminal prenyltransferase (PT) domain of tp...
Q4WQZ2
MPDIQPITVYGKGGPNPPRVAIILAELDLPHKVIEVPLSKVKEPDYVAINPNGRIPAIYDPNTDLTLWESGAIVEYLVSHYDPDHRISFPAGSNLAALATQWLFFQASGQGPYYGQASWFKKFHHEKVPSAIERYVKEINRVTGVLEGHLSRQKVAADGDGPWLVGGKCSFADLAWIPWQVIVTAIIQPEDGYTVEDYPHVKNWLDRMMARPGVQKGMADIFPST
Function: Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process . The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC . The at...
Q4WQZ0
MLEKVFHEKSFADQYTYGAKISELYAETLITESGIAKSHQRPLIILDNACGTGSISSTLQRTLDERNKRSLKLTCGDLSEGMVDYTKQRMQAEGWNNAEAKIVNAQDTGLPSDHYTHVYTAFAFNMFPDYKAALRECLRILQPGGTLATSTWKTANWCTIMKPVIATMPGQLSYPTMDEINTMLNKGWDRESDVRAEFEQAGFDHVNITTVEKQCLLPVQEFGEACKILLPYILSKFWTQEQRDQYEADVPSYLMRYLEREYGKDGLAPMKGVAIIASGRKP
Function: Methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process . The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC . The atrochrysone carboxyl A...