ids
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4.4k
A0A1V5LC86
MIREAVEAFNIKSVELEGYEADDLIATYAKLGIEAGMNVKILSSDKDMMQLIGLGIELYDAFDFSLVDNEKVMQKFGVTPDKVIDVQSLAGDSSDNVPGVKGIGPKTASSLINDFGSLEGIYENLDKISKPRTKALLEEHKDLAFISKKLVTLCNHAPVEVGLKDLEIINPDFDKIMDFMRANEFKSLMNSLPNWQEKREEVIRKVKSESAKYITVDEEKDLKEWVERAINEGVVAFDTETDSLDSFSANLVGFSLCIKEGEACYVPLNHKAKQESLFEETSIKPKQIDFNKALEILKPLLTDESVMKVGHNIKYDMNVL...
Function: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. EC: 2.7.7.7 Catalytic Activity: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) Sequence Length: 818 Sequence Mass (Da): 92021
A0A950XUB8
MPTEETSFLFRHPSRAVLRRELRDFWNDLVRRIPLPGATCLISTDIELRALNKRFRRKDHGTDVLSFPGDHGAPGEIAISLDRARAQALEHGHSVEEELCILMLHGALHLAGMDHESDSGDMARAEARWRRRLGLPRSLTERAGRAGFRTQARLQPRPRAGAPKRPSQAKACSTV
Cofactor: Binds 1 zinc ion. Function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. EC: 3.1.-.- Subcellular Location: Cytoplasm Sequence Length: 175 Sequence Mass (Da): 19655
A0A3S3TSY1
MGVCKISDPGAVEAFDPARFTEEKVAEIRRFVGDGKAAIATSGGVDSTVCAALAHRALGERLVCFFLDTGFMREGEVEEVKGILTSLGLPLRILAVSDRFMAALKGKSDAEAKRIAFRETFYTVLGEAAKAEGCDVLIQGTIAPDWIETAGGIKTQHNVLEQLGVDTKTSFGFRLLEPLLELYKDQVRRLAVHLGVRLDASQRQPFPGPGLMVRCIGEVTEEKMEVLRKATAVVEGELSRLDPPPKQYFAAVTEDDRREADSRMARSAVGPNGRAWYLGARVTGVKGDERAYGRMVVVEPGDQADPADLLGIVERVIHED...
Pathway: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. Function: Catalyzes the synthesis of GMP from XMP. EC: 6.3.5.2 Catalytic Activity: ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate Sequence Length: 396 Sequence Mass (Da): 43097
A0A1V5LAP7
MANLKQLKQRIAVVNSTKKITSAMKMVAAAKLRRSQDALNATRPYSEGMKYLVGKLIKNVIAHGPTGQEMPLLIKGNGDDKKHLLLIVSSDKGLCGGFNSAIARLAKKTITDLKKQGKDVQIMFVGKKARDALISEFKDLEFKQTSKNDDNQPQKLNFFDETVGAMIEHLFEDNAFNCCSVIYNEFVSTVTQKPTVKQVLPLNIKDFEQEFKNEENQKADYDYEPSEKEILEKVLPDYVQNLISRSILESFVAENAARMTSMDAATRNAKEMINKLALIYNRTRQSMITTELIEIISGAEAL
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. Subcellular Location: Cell membrane Sequence Length: 302 Sequence Mass (Da): 33934 Location Topology: Per...
A0A2E5FJE9
MDSHSFRGCRYEIKKAVHTGSSGLVKIAKESRYVTIARLLRPRGNRGELVAENLNSETSEAQDDSLKNFLKLDTVFFWDSNQQRQETAIEQAWVHRGRLILKLRGVDSIGAAERLRNINLQIPQEYLEPAPDNGYYFEDLIGCVVHDIEDGHLIGLVEEILEPGGPLLLQVKMDNHEVLIPFVKDICVEIALGEKTIRVRMPDGLESLNS
Function: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but ...
B5Y8Y6
MGNKGTQQEGVMELKEFVGQTTAVSSVSFSVEAAKKLGKMPDHMLFFGPPGLGKTTLARLVAQEVAANFVETTGNSLTNVKDVLNILLSFSRPTVFFIDEIHRIPKSVEELLYAPMDEQVIRVMVGKNKTARIIKFDLQPFTLIGATTKISFLSKPFLSRFSIKISFNYYGEEEIGKIIKEELAQQGLDISAEALREIAKRSRGTPREALQICRRVVEYAALNHLETLDVGAIIDLFNLLNIDEYGLSPLDKDYIRTLAETFKGGPSGIRVLASALGMDVETLEGVVEPYLMMLGFVTVTSRGRKLTDKGWKAYEKVICS
Function: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an ...
R5QJ61
MREDFLSVIAARGDTQIKQNEGLAKYSTFKIGGEARYAIFPENKNALVFAVAACREFDIPCRVIGCGSNVLFDDGGFSGAVIFTKWVNKTEVSENIIRSECGLPLSALSTIAKNASLSGLEFAFGIPGSVGGAVYMNAGAYGGEIKDTLTEVEYFDTETETLHRAPAAELALGYRESIFQHKSYLLLSATFALHRGDRAEIEEKMASNMAARKDKQPLEYPSAGSAFRRPVGHFAAKLIDDAGLRGLSCGDAQVSEKHAGFIINRGSATSSDVLELCRIIKEEVAGRYGVSLETEFIHIKD
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC: 1.3.1.98 Subcellular Location: Cytoplasm Sequence Length: 301 Sequence Mass (Da): 32583
A0A0D2LRU2
MCSQDHATCACVRCQVVNCVGLLNYKFFLQFLFYTLLASCLAIALMVQPMVAFVTGTDFTGAPGPFIVVVMDGAFAAALIGFLGMHWQLLAHGCTTIEMYEKERANPWPYDRGFRRNFEDVMGRSMQPNALTAAAAICPRLRDSILSRAAIAEQILLHDTDAGTIITRLQPALAAPSADSPAAAAAAAETPALSSPRGAGHSPRHGHSRGARQPSHARPPAGLGALELVVGWAELEQLLLEQLPAGTVEWGSRVTRLQEDAQHVRLTVGRSGDSGSSDSNGGGEGSSEAGVIIIDAEVVVAADGALSAVRQACVGGAEKA...
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 347 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 36131 Location Topology: Multi-pass membrane protein
A0A4Y3PJ11
MKPLALEQATINAEGLLLAGSPHLVLSSVHFDTRQLKAGSLFVALTGGARDGHDFLLQAAEQGAVAALVSNQEKIPAGLPEEFGLILVNDTLRGFQKLAAAYRKDFAIPHIAITGSIGKTTVKDIVAHVLEARSPVYKTYKNLNNHLGVPLSLLQMEPQHQAAVLELGMNHAGEIDLLASLVKPEISVITYIGESHLEFFGTREKLALAKAELLPHTAPDGLVLLNKDSEYLPRVAHLYAGEIMYYSVLEPCDIWAEHIQPNDNGTQFDVCFANGERFSAFLPLHGKHSVLNALPAIAIAKRLGMDTEQIVQALSTVKLS...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. Catalytic Activity: ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-d...
F0S203
MKLFDIEAEYSVLGSMIVQPSFIFRGVELLQPEDFFKEQNKVLFRFIRDLIAEGYTETQLNEISFKDELIKRNLFEKVGGEEHLGYVVEFALDSYEKFESACKIVKDKALLRKIIDVAKHINEKVEETPDPDTLIDDIEKRVFSLSEERITNTLTPICEVIPEIVKKIEELASRREMVTGLPSGYTELDRMTSGFHDSDLIILAARPSMGKTAFALSIAYNIAVKEGKTVAFFSLEMSKEQIVTRLISQDSGVPLHKIRSGFLFPQEIDKILESADRIREAPIYIDDTPGITILEMRAKSRRLQSEKGLDLIIVDYLQLM...
Function: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. EC: 3.6.4.12 Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Length: 904 Sequence Mass (Da): 104222
A0A957AY83
RLEFLGDAVLGAVAAEYLYVEDPDADEGQLTRRRVALVRAETLVRWAREIDLGSYLYLGGGEKPGEGARDRMLAGAFEAVIGAIALDRGFGAARKFVMQLLERDADLLLTQAEGAGNPKGRLQELLQERHRQGPKYRTVGAEGPDHARTFSVEVLFGDEVLGAGSGPSKREAEQAAAAQALRRLNAG
Function: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the o...
W4VLV6
MYEIKQYLQNRDDVYSIINGIESGLKEQLVSGLSGSARSMFTSMLQEASNKKTIIVTHQLTQAQQLYDDMLEFSNEQHVYLYPVNELLASELAVQSPELQSQRIASLSNWLHNKTGILIAPPVAALKRMLPPIEYWEEYQLHFKLTQVIDIEDTIQKLVDMGYARQEMAASPGEFSLRGGILDVYPITEVQPIRIELFDDEIDSIRYYDAESQRTLEKISEITVLPATELLLKDHDIVASAQKLEQSLADMLKKIKNKLDQQNLNESITADIDRLQHCERFQEMKKYISFFYEHNYSLLDYLSKDGLIVLDEMSRIQETA...
Function: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. EC: 3.6.4.- Subcellular Location: Cytoplasm Sequence ...
A0A1B1ADA8
MSLRACFAVLEAGQPLPTETVDGAFREIMDGVAAHDDIKRFLTLTTPLMHDPSLIASGARALRSRMVGLTAPAGAVDVCGTGGDGAHTLNISTAVAFVVAGCGVPVAKHGNRAMSSKSGAADVLEALGVRLTGDIALLERCLREARVAFLFAQNHHPAMRHVALARREIGKRTIFNLLGPLSNPAGVKRQLVGVFSADFVDPVAGALHQLGCEKALVVHGAGGLDELSAAGQDANCVATLDGGQIAHQPATRAADVHPDLRGGAAQENAEEMRAMLSGGGRPGHRAAVLINAAAALFVAGRAAGVVEGHRLAIESLDSGA...
Cofactor: Binds 2 magnesium ions per monomer. Pathway: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. Function: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA). ...
A0A2W4JNN3
MFYRGRARGGSPALSGEGDERADWVHVDVMDGHFVPNLTLGLPVVQSLIAVSEVPIDCHLMIEDPDRWAPAYAEAGAHNVTVHAEAATDPVMIAKNLRAAGAKAGLSIKPQTALDDFVDVLKHYDTLLIMSVEPGFGGQAFIPHVLEKVRAARNLVDTGHLRLLVEIDGGINADTIEQAAEAGVDCFVAGTAVYGADDPGKAIAALRRKAAEV
Cofactor: Binds 1 divalent metal cation per subunit. Pathway: Carbohydrate degradation. Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. EC: 5.1.3.1 Catalytic Activity: D-ribulose 5-phosphate = D-xylulose 5-phosphate Sequence Length: 213 Sequence Mass (Da): 22554
A0A350UFW4
MPRIRLTLTGAVQGTGFRPFVHRLAGELGLSGWVRNTAAGVVIEVEGASAEEFRLRLCAECPPAAWIAQLEATQLPPARLSGFKILESEDEDQPVAAILPDLATCPECLAEIRDPDARRFRYPFTNCTRCGPRFTIVESIPYDRPHTTMQGFALCGDCAAEYRDPADRRFHAQPIACPVCGPRLSERLECASEALKSGQIVALKGIGGYQLLVDARNESAVARLRERKSREAKPFAVLAPDLEAVRAVAEVNGEEAGLLESAAAPIVLLRARPDSGLAASVSQGSPWVGVMLPCSPLHHLLLDQFPHPVVATSGNRVGEP...
Pathway: Protein modification; [NiFe] hydrogenase maturation. EC: 6.2.-.- Catalytic Activity: ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate Sequence Length: 712 Sequence Mass (Da): 77066
W4VQN8
MFNEHITFPIDTLAVNLAGSFLLAYLTTVVFTKWRIHPLYKTAIGTGFVGSFTTFSTLSVETMDLFQNHYYFLGILYIALSIFGGLWMSRLGFKVRKEVTEG
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Subcellular Location: Cell membrane Sequence Length: 102 Sequence Mass (Da): 11585 Location Topology: Multi-pass membrane protein
W4VLM9
MKNLTSAQVRQMFLDFFKEKNHGVEPSASLVPKDDPTLLWINSGVATLKKYFDGRVVPENPRITNAQKSIRTNDITNVGYTARHHTFFEMLGNFSIGDYFKEEAIDFAWEFLTGKQWIGLNQEKLSVTVHPEDEEAYVLWRDKIGLPEERIIRLEENFWDIGEGPSGPNTEIFYDRGAAYGGEDATDPELYPGGENERYLEIWNLVFSQFNHNPDDTYTPLPKKNIDTGMGLERLVSVIQNTKTNFETDLFLPIIRETEKLANTTYNASEATDVAFKVIADHIRTVTFAVSDGALPSNEGRGYVLRRLLRRAVRYAKQIG...
Function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. Catalytic Activity: ATP + L-alanine + tRNA(Al...
A0A1H9VMA7
MKKKLFAAITAVCLLAVAFMGCGFEGTENGDLKGNITLAGSTSMEKLCEAMSESFMEANPGVTVTVEYTGSGAGLESLAAGSVDIGNASRGLKDGEKANGSVENVVAIDGIAVIIDKNNSVTDISSENLAKIYTGEITNWNEIGGEDQPIVVIGREAGSGTRDAFEELLEVKDACAYAQELDSTGAVLAKVASTPGAIGYVSLDVVDSTVIGLKIDGVEPTEEQILAGSYLLQRPFVMATNGEIGEQNELVQAWFAYINSDAGKEVIKKVGLIIPQ
Function: Involved in the system for phosphate transport across the cytoplasmic membrane. Subcellular Location: Cell membrane Sequence Length: 276 Sequence Mass (Da): 28766 Location Topology: Lipid-anchor
A0A4R4YLT9
MIFAPRREDVIVFDAPAYWHSGGSGRPQVSRVIGVPGAEVECCDGSGRLLVDGAPLEEPYLTEPASKLKFRIRVPQGRIWVMSDHRHISRDSRYHQGDGGDGTIAVSDVIGVVDLP
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Membrane Sequence Length: 116 Sequence Mass (Da): 12652 Location Topology: Single-pass type II membrane protein
A0A956ZTK6
MRVGLIGNPIAHSRSPRMHNAAFAALGMNHTYELWETEPDDLAERVATIRQSEILGSNVTVPFKEKVVSLVDEVSETSRRIGAVNTIIPHDGKLIGDNTDAYGYAASIRESYPGYTPERALVLGAGGASRAVIVALQEMGAGEVIIVNRTLARAEELAAELGASAAGWETLPDLMPTASLVTNATALGWYDERVLDESMVAMLPQGAIVTDLTYANTPLLQDAAAHGLHTLDGLGMLVYQGVRSFELWFGITPPVDVMWAAARG
Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. Function: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydr...
A0A318N1S7
MASVVLIINAGSSSLKFSLYRSQNNSDFELYSKGLLEGIGSGPHLKITDRQDKIIHEKNWTNGRYAKLDVRDELLDQVLKWLFDFIKKDRILAIGHRVVHGGMKYYRPVVIDQKIYSYLDSLTPFVPLHQPASLAPMKVIMDKYPDITQVACFDTAFHATMPDKAKRFALPRKYYDSGLRRYGFHGLSYHYIVHYLQKNKSPLIKGKIVVAHLGNGSSVAAINKGKSIDTSMSFTPLDGLVMGTRTGQIDPNVVLYMTREEKRSPDEIEDIIWKQSGLLGVSEVSSDMRGLIHEIAQNGPKSKFAKQALDLFIYKLIGEI...
Cofactor: Mg(2+). Can also accept Mn(2+). Pathway: Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. Function: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. EC: 2.7.2.1 Subcellular Location: Cytoplasm Catalytic Ac...
A0A1Y0I4Y5
MKTVVGLIILAGALLLGTLAGTLMLHDAGYVRVSLGHYMFESSFWFALCLIIGLFATIYLIFALLFRSLRGFQGISQWIDRKSQDAANREVTKGMLEYTEGNWPKALKHLKGSASKANSPIVNYLAAAQAANEQGLVHDAEEMLQKAREVPGSELAVGLTEAQLMVNNNQLESAVEKLKTLHSLAPQNPQILRQLKALYSQLQDWPQLTQLIPELRKKKIFVASELDELEQQCWTNVLQETTESIQKTMGSSYNPAQLEAVWEKIPSDLRKSEPLLLAYSASLRAIKHDDRAEMLLRKTLKQNWNDQLVLEYGLIRFSSP...
Pathway: Porphyrin-containing compound metabolism; protoheme biosynthesis. Function: Involved in a late step of protoheme IX synthesis. Subcellular Location: Cell inner membrane Sequence Length: 414 Sequence Mass (Da): 46670 Location Topology: Multi-pass membrane protein
R6S2T0
MIRISSHQQNNPIQGKEEDVRDVAIRVIRILSRSWKDRMLTDEPFVMAARDIYPSEALQFDKAKVLGFVTMYGTINSHTAVLARTKGIPAVIGLGESLKEEYDGKTIIIDGYEGKIYIEPDYATLTKMRERKDANLRHVRNLERLKGKENITQSGQKIDICANVGTREDIENVLRSDAGGIGLFRSEFLYMEMGSKLPSEEQLFQVYKLAAESMGANRVVVRIADFGGDKMVESVDLGEQANPAIGLRGIRIMMEKEELFLPQFRAILRASALGNVSIMFPMVTSMEEVAAAKALLEKAKKQLKDEKTAYNENIEIGVMI...
Function: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfer...
A0A066TK07
MKKLLWVLFKSNLIVRMLVCMIIGAFIAAFLPQYGVKLEFLGRVFIQALRAAAPILVFVLVISSIVNNKFDNVSSIKSVAWLYAVTVLISAVLASTVSYLYPLHLVMDVPPISEKPPEGVAEILMNIILKFVDNPVDALANGNFLSILAWSTALGIALRQSSEATKSVIKNWSDATIWVVRLVVAIAPYGVLGLVASHFTSDGLAKLRNYLELIGILLGLMVFVALVINPLIVFLNFRKNPYPLVFTCLRYSGITAFFTRSSAANIPVNIRLAQRMQLPEEIYSLSIPLGVTMSMNGAAITITTLTMATVHTLGMDVSFI...
Function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Catalytic Activity: L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out) Subcellular Location: Cell membrane Sequence Length: 411 Sequence Mass (Da): 44348 Location Topology: Multi-pass membr...
A0A7X2SUQ1
MANYFNTLNLRNQLAQLGKCRFMARDEFADGASFLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRAEAIAEKRPSWRKATDNGFKVGTYEQLIPQADLVVNLTPDKQHSAVVQAVQPLMKDGAALGYSHGFNIVEVGESIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVAEGTDPAYAEKLIQFGWETITESLKFGGITLMMDRLSNPAKLRAYALSEQLKTIMAPLFQKHMDDIISGEFSSGMMADW...
Pathway: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Function: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In th...
R5RGB9
MGRILSYVMFGFFVCTTIMSASVLRSREKLKINNILFALVCIGSSIWSFCFGFIWIQTDPLRAYYWRCAGMVGTFMYMICAMLVIARWCGQKRLWISAIKGFTFSAILLYPFLMQKSNTVYHMSAIGMTYVFVPGIWNTLYDIYCIVCAIGLCSVCAIGLFALSGFMKKNGERKWERIVGKRLLFCESVIVAGMLLDTIMPVFGFNAFPGSTLSQLFGVLLLYRIYLFINKNKVKLENVSEFVYYSVKSPILIYDYNKKLRIVNKSATDFLKISEQNCENVLFTDLFEMGNEKLKYGGYSNKIDVRCRANGAHCRLDINQ...
Function: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporula...
F0S3D2
MKHLISAEDISKEQFQEIYELSQQVKKALREDRKKFSVLKGKCIVNLFFEPSTRTRTSFEKAGKFLSADVINISTSTSSVKKGESLIDTLKNLDMMHPDVVVLRHPCEGAPYTVKNYINASIVNAGDGCHQHPTQALLDAVTLTEHLQTLEGKKITIMGDISHSRVARSDAILFRKLGAEVFVYGPSPMMPRFPEAIGVKKLSSFEEVAQISDVVILLRIQLERQSARKVFPSLREYAELFGMNKKRLEMLKPDTVILHPGPFNRGVELNNDVVTSTRSLIFQQVETGLAVRMVVLSLLCGKTEKLKEEIDG
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. EC: 2.1.3.2 Catalytic Activity: carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate Sequence Length: 312 Sequence Mass (Da): 34972
A0A1F6NVX6
MLINENRIKIAVQKRGRLRVPSFDYLNSIGLYFGIGESNDLIVSCQNAPVDVLLVRNRDIPEYVRTGAADFGIVGLNTLYERDECYPVTNQFEFGRCSLVIAASINSGINSVTKLQNKRIATSYPNSLRRYLNENGIIANVIEINGSVEIAPLLNIADAVCDITQTGDTLRKYGLKPLATILRSQAVMIEGANRNNVDSFKEKYIYASNKVKTI
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. Function: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosyn...
A0A2G2L243
MLKNTNTKAWHKWIAIIFSLSAIWLTNGVVMAENYGILKDAVPTIVEQPRYPRKAAMEKIEGWVKFKFDVDELGQPYNVELTNAEPRRVFERDARRAIYKWKFEKNKSQKGLTYTMVFKVKSLELLTEG
Function: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the rele...
A0A0D2M6M2
MRVACHSEPVLAAIAGDAANDDGGLPSASLACLEQSLERARSLSATPSGSDQDEAQIGSAEYQVWLAQHPCLLTKFEEFQKQLDGRRLAVFLDYDGTLTPIVSNPDAAIMSDQMRETVRQVAGMFPTAIISGRGREKVESFVRLPELFYAGSHGMDIVGPCGATVGSTAGGGVVGGGSGDGGVVEQFRFQAAAEYQPLIDRVYSQLRESLESIPGASVEHNKFCVSAHFRNCHPDSWQRVVSAVDAVVAGAGGGRLHVTRGRKVLEVRPTVDWDKGSALLHLLGVLGLAGQPDVTAIYLGDDKTDEDAFAALAGAGAGAG...
Pathway: Glycan biosynthesis; trehalose biosynthesis. Function: Removes the phosphate from trehalose 6-phosphate to produce free trehalose. EC: 3.1.3.12 Catalytic Activity: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate Sequence Length: 526 Sequence Mass (Da): 55779
A0A1Q9YB91
MLSAIDKTQKEELAAYLQNRSQEISADILAKAAAIIDEVRKDKDNALKKYTELFDQVSLDDFEVSKEELEEAASKADADFVAALEDASKNIYEYHEAQKKEGYRIERSNGAFLGQRIMPLASAGIYVPGGRAQYPSSVLMNAIPAKVAGVREIIMVTPPSKSGSINPNIAAAAKVAGITRIFKVGGAQAIAALAYGTQSIPAVDKIVGPGNIFVAAAKKLVFGKTDIDMIAGPSEILVIADENANPAYAAADLLSQAEHDPMASAILISNSKKMIDAVNKELRIQTDRLPKKAIIEESLKNYGKSILTDTLEEAADISNA...
Cofactor: Binds 1 zinc ion per subunit. Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. EC: 1.1.1.23 Catalytic Activit...
A0A5J6YU22
MTFPDAPGRGKPEKQYVEDPAIATLETLGWRLTPVSEVQRVGPRSAILRDRLHAALLRLNPGLSAEALELAVRRVSARERLGLVEGNREVHGVLTHGFSVRLDDDPGGLPSRTVQLADFVDVSRNEYTLIRQFPVVGEGGRRIEFDLSLFVNGVLWAVLECKYARGDLGAALAEGHAQLSRYQALGDYVGRGAPSVFASVQVLGVLCGSEAVSLGVYGAVGASERAFAPFPEAYPQGAAWLADALGLPPGGQPNPQQILLYSVFAPENLLEFARSFTVYEVKEGRLIRKLARHQQRVAVDRVARRVLGLLPVGPEDDPAM...
Function: Subunit R is required for both nuclease and ATPase activities, but not for modification. EC: 3.1.21.3 Catalytic Activity: Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed. Sequence Length: 1010 Sequence Mass (Da): 112567
A0A0J9X5C8
MNTDSTLKNLLWNGSISVRLVLSQDEARNFVDYDYYVSINVPRLSYLHLQLPSALQFFRPLLRHPEDADMLDWWLEFEGVPIKWNWPIGLSFDLLTNHDPNKGPDAYAEIVPWTLILHKKNYPKDRILSLDDGIETVRSYWLNQIKEASYIRYGNSKAVLNLSKDDSDSLWSHLMQTSPRNLPLRIYLPISNSVLQYPLPHDPNQTLGAALNACMPRLFPSKRTCVIARPVMHGVELPLRTPVGALFESGAVFCDGFVHVSLVML
Function: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Subcellular Location: Membrane Sequence Length: 265 Sequence Mass (Da): 30331 Location Topology: Peripheral membrane protein
A0A1F2PA75
MIGVFLCGCDGEVSERIELKWLGEVAERDPDVGYLEIDEHLCSKEAVRKIRSIVESKNLDRIVIAGCSPRTHEKIFDDLAPIVEFANIREQAAWVHPEKEEATRVAADILQSAIVRAKLAAELEPVRVPIEPSCLVIGGGVSGMQAASDLSAQGYRVYLVERDERLGGRVKRLSMTFPTISCGFPCRHDCPECELTPKEEELYASEFVEILTSTEVMEVEGRIGDYHVTLRTPEGVREIKVGTVVIATGTKTYDPSRIPEYGYEFEDVITSIELEDLYMKHRFLGGGGELRRPSDDAIPKRVDFIQCVGSRGEKGGNPYC...
Pathway: Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. Function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). EC: 1.8....
A0A1F2PAR4
MELDTAHRRMIESLKRLGVKQEVLRAMDKVPRHYFVPENRKHEAYVDHPLPIGDGQTISAPHMVAIMCDLLDIEPGNRILEVGAGSGYHAAVMAELVGEEGKIYTIERFEGLAATARENLRRAGYTNVEIFVGDGSLGLPEAAPFDRINVTCAAPDIPPPLLDQLKVGGKMVIPIGRYVQDLHLIEKRADGISRKIKGGVVFVPLIGEYGFKE
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Catalytic Activity: [protein]-L-isoaspartate + S-adenosyl-L-m...
A0A8J6HEJ0
MYLNGDTAFLVWMVPDPGSLALVLGMVGRSDANGNGRCCSDKAELEQGVDGCSIFDDGADKRVIGVDEGLGGAYTNAVEKVQPVASLLESLLDVEDQGTVLIGHHSQIPNFGTLWDWMTVEMKCLLAEVTAAFDVAGRCHQDAVVFERLYLTPQVSNGRRLQVSPSRWWSDRGCTVWFTGLSGAGKTSIAFELEAYLIQHGIPAYGLDGDNMRTGLNKDLGFSKQDREENIRRVAEVAKLFADAGQICLCSFVSPFAEDRELARRIHRDNDLPFFEVFVDCPLLICEQRDTKGLYQKARQGTIKGFTGIDQPYEKPEHPD...
Pathway: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. Function: Catalyzes the synthesis of activated sulfate. EC: 2.7.1.25 Catalytic Activity: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+) Sequence Length: 395 Sequence Mass (Da): 43908
A0A508A6G0
MGAMSTQPHASPEPDDREAARPIDERPTRIRVDLERIAGNLRAIRAHVGVPVMGIVKANAYGHGLVPVARHLQAAGVDQLGVAFVEEGIALRRAGIRAPILVLGGIFGHQIGRFISHDLEITVSSLDKLRQVEAAAEAMGRRAVVHLKIDTGMERIGVHSYSAGPFIEAAVASPWCEVKGVYSHLACADDPASPATAAQVARFAEACEHFTRIGAPMPLRHLANSGGVLHFPDTWLDMVRPGILLYGVLPDPASRPTVAVQPAMSLVSQVVYFKVVKAGHAVSYGGTWTATRDTRVVTVPIGYGDGYPRALSSRGEVLVR...
Pathway: Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. Function: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. EC: 5.1.1.1 Catalytic Activity: L-alanine = D-alanine Sequence Length: 400 Sequence Mass (Da): 42639
C6JR26
MERTREEKIKRKFIGAHVSTVGGPFNAPKNAKEIGARAFGMFVKNQRRWEAKPLTAEDIEKFKKALKENGYTNEYILPHDSYLINLGAKDEEKREKSLNAFIEEIKRCDQLGLKYLNTHPGSHLNEISEDECINNIADCINKAIEVTENIIIVLENTSGQGSNMGYKFEHLGKIIEKVKNKERIGVCIDTCHTITAGYELKDEVGYKKTMAEFEKYVGFKYLKGVHLNDSKFDTGSRKDRHDSIGKGILGMKFFERFMNDERFDNIPIILETIDSSIWKEEINLLYSLIK
Cofactor: Binds 3 Zn(2+) ions. Function: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. EC: 3.1.21.2 Catalytic Activity: Endonucleolytic cleavage to 5'-phosphooligonucleotide end-produc...
F0S3E5
MEVKKLPAHVLTTIGIGSVYPVYFPENLEELKSILKSEKVYIIGGGSNTVLPEKIESKIVSLRKFKKIKIKRNSIILGAGVSLSEVLKLQIKENFSLFEIFAGIPRATVGGLVAQNAGAFGREIKDFLEKVVYLDLDSYEVATLKNFSSFSYRKSPFPKKGVVLETEFKIEKDNHVKEKIKKFVFFRLSKQPPFYLQTAGSTFKNPLGDSAGKLLDLVGMKGFKVGGVKFSEIHANFCINEKGSFEEFKKLISIAKERVKEKFNVELELEVKIPR
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC: 1.3.1.98 Subcellular Location: Cytoplasm Sequence Length: 275 Sequence Mass (Da): 30919
A0A1W9V5X6
MTKALKIFSDFDGAISLIDTGDLIVDHCIGRVARRAIDDKIVAGKMSFREGFAAQFAGVHLTWDEAVGRLQLQDGLDAAFPPFVRWTEAANIPLVALSSGFEQFIRACLTPMRLAHLEIRANRALVQGRNWQIAFRDDTPSSHDKSAALREARSQGYRVAFIGDGISDIPAARVADILFAKKGERLAVPRHGRGHRISPTELNSRANIYALKSLGARYIISVSACGSLREDLAPGHIVIPDQLVDRTRLRDLTFFSDGLVAHLSAAEPFSSPLSELLYEAVQETGARPAHLGGTFVVIEGPRFSTKAESKIFRQWGCDII...
Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate....
M1MTM2
MLRTLLFYSGMILSLVFASIFRIRIKFLTFTNNIKGRNNFIHKVTHTWAKFILKIAGAKVNVIGLENIPKDETVLFVSNHESNFDIPLLLGVIDMPKGFIAKKELENWPFISTWMKYINCIFMDRDNLRKSAEAIVDGINLLKSGHSMVIFPSGTRSKGKSIDEFKSGSFKLATKSKCPIVPLTINGTYKLLEENNNRIKGADIELIIHPTIYVDKLTKDELEKLPNTVHSIIINSCKDY
EC: 2.3.1.51 Catalytic Activity: a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA Sequence Length: 240 Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Sequence Mass (Da):...
A0A3M7NSR1
MDEYRFDDSRLKKQMDDPSKTPLLLVACGSFSPITFLHLRMFVMARDYVKHNTDFEVVGGYLSPVSDAYKKQGLAPAEHRVAMCQLAIDKAANWLMVDTWEAEKKEYQPTAKVLDHFEYEINQVRKGVDCGNGMRKAVRISLLAGADLIQTMSTPGVWSEKDLDHILGRYGTFIIERSGTDIDEALASLQPYRDNIHVIQQLIQNDVSSTKIRLFLRRGMSVQYLIPAPVVEYIEQNHLFGDDGRSSSMTSINLPNAVDKGKDKDKGGDCREQELKGH
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. EC: 2.7.7.1 Catalytic Activity: ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate Sequence Length: 278 Sequence Mass (Da): 31430
A0A444U637
MAANGNLQKAIDLASKAAQEDKAGNYEEALRLYQHAVQYFLHVVKYEAQGDKAKQSIRGKCAEYLDRAEKLKEYLKKKEKAPAKPVKESQSDEKGNESDEDGDPEKKKRQNQLQGAIVMEKPNVQWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWTLDSAIRRRFEKRIYIPLPEEHARTFIFKLHMGTTPTSLTEADYH...
Pathway: Lipid metabolism; sphingolipid metabolism. EC: 1.1.1.102 Subcellular Location: Late endosome membrane Sequence Length: 772 Sequence Mass (Da): 85592 Location Topology: Peripheral membrane protein
A0A7V8V254
MKQQLLPLGRLVVRLNETATLGVFAHLKFPMARTKLKSRSEPENSSPVRGSLAAFQSHVFAWFATHQRDLPWRKSQDPYRVWISEIMLQQTQVATVKEYFRRFTAEFPQVSDLAAANEQKVLRLWEGLGYYRRARQLHAAAKEIVERFHGKFPQTVDEIQSLPGVGRYTAGAIASIAYGHKVPILEANTQRLFARLTGWDQVLTTSASQKRLWQFAEDILPDQDVGIFNQALMEIGSLVCTPKNQSCSQCPLAAHCEAYQQDRQDEIPQPKKKIEFIPITEIALVVRRKNEVLVRQCGQDERWAGLWDFPRFAVADVNEL...
Cofactor: Binds 1 [4Fe-4S] cluster. Function: Adenine glycosylase active on G-A mispairs. EC: 3.2.2.31 Catalytic Activity: Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site. Sequence Length: 404 Sequence Mass (Da): 45787
H0QZJ5
MADIPDVDDAQSVDLAPVTHHAYSAVDDTVEPAYPFDDVDASDHDAPDRRRRRTVVLAAVIVCLLVMVGGVGYYGLRFFGVVGASDYSNAQGTGDVLVTIPENSTLRDFGRILTDKDVVGSVKAFTRAADGKMLSAGIYKMRTQIPASKAVAMLADDQWSYRVGRVVIPEGAQLDSKKGIDGKVTPGVFQRIAEATATTVNGSKVGPTIDELATAAASASLEELGIPQWAKTEVTALNGDHRRIEGLIAPGTWESIDPSASATDILRQLITDSARQYEQWGLLSSNDSGLSPYQTLVAASVVEREVREANDFPKVARVIL...
Function: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. EC: 4.2.2.- Subcellular Location: Cell membrane Sequence Length: 428 Sequence Mass (Da): 46191 Location Topology: Single-pass membrane protein
A0A673N0Q2
MGYDVTRFQGEVDEDLLCPICSGVLEEPVQAPHCEHAFCNACITQWFAQQQSCPVDRTVVTLAHLRPVPRIMRNMLSKLQISCDNAGFGCTATLRLDQLQSHLKDCEHNPKRPVTCEEGCGLEMPKDEMPNHNCIKHLRSVVQQQQTKIADLEKSAAEHKHQLAEQKRDIQLLKAYMRAIRSTNPNLQNLEESIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLIDSGCPLSIVNDLIENAHERNWPQGLATLETRQMNRRYYENYVAKRIPDAQPYLDLFTVVYIRTVFLSIICHSTS
Pathway: Protein modification; protein ubiquitination. EC: 2.3.2.27 Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Sequence Length: 308 Sequence Mass (Da): 35152
A0A673HRZ1
MKPQSDPASRGPALSSQGVLNPLQKASQFQSLDSRRFVQEPLGFQEKQLLQGPVKPLDWSFPIVPEVQSELAVDFQLRQPVTPSSVAVQCGENRVLVEVKKDLFSNGQLIQPSGLSMGGCPVVGEDSTSRVLNFEYELQDLEDNSHGNDFNLLQMTEDELVYTFALTYPPEAFAGTPISRANRAVVGVQCHYQRFYNVSSNALRPTWVPYTSTEFGEEVLMFSLKLMMDDWSYQRPSNLYFLGDVINIEASVKVYNHVPLRVFVDSCVATQVPDVTAHPRYSFIENHGCFVDAKATASSSRFMPRTQEDQIRFQLEAFMF...
PTM: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. Function: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polys...
A0A328R5Q3
MRDHSAYLDLVERLNAYSHAYYVKDKPLISDHEYDQLYKEVLGFESANPLLIAVDSPTQRIGDRPLESFVPFVHSTKLPSLGNMFSKQDFLDFSKRMYKECVEESILFSIEPKIDGLAVALRYEDGVFVSGGTRGDGVKGETVTENLKTIRSLPMKLSKPVTIEVRGEVYIKKSQFEMIKEDFANPRNAAAGSMRQLDSRVAAKRHLDIFVYQGMDTEFESHCKTLDYLKSLGFPVIPDVFQSSNLDDLYSYIKDYEAKRFSFDWEVDGVVCKVDDYALQETLGFTAKAPRWAMAYKFASEEVITKVLDIDIQVGRTGVL...
Function: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. EC: 6.5.1.2 Catalytic Activity: NAD(+) + (deo...
A0A8J6HUK5
MSLDNICYITVLVAVLGLISPALGIRCFQCNSFVNPECADIPVNDTHSPFLHKCEQRDDYQMFCRKVVQTVLDAPQFTRITRTCGWYLNKDNRTNCQVSDTDFKMETTFHCIRCFNCSSRTNMNCVTFEGDNASMIVECPQPNAFCRKTRQIITADSTTIITRACGWIKFEEHSGDYCMVTNTNFKQETSSGSTVVPVARTNDSVGRPCCGDAPDA
Function: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excita...
C6JLH2
MITTEYISFLESLMSSLLGMSIVFIALIFLAIFVMIVSRIISVLEKNLIKTTDTKATVSVSTTGANTKKDNKDGVKIAVITAAISEEMKQPVDKFIITSIKKI
Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate EC: 7.2.4.2 Subcellular Location: Cell membrane Sequence Length: 103 Sequence Mass (Da): 11273 Location Topology: Single-pass membrane protein
A0A5C7JMY7
MSHTPAITGSTSAFRTIRPLPGRGRHEIGRWWASAKTNSSRDPWFLHVMSDVVHLFESMPESPESPISMSRLQPQPIVQGTASEAVERAVELLREEWRDGFLGRKLERARMLVRQAQDLASDTGISISLARIDVLLARYLDSPEEARKELLSEIGKDLSVVRDRLPSVLAAPVRQTPTAPPVKRVARPAASRQVSLDAPVTLLPNVGEKKAKPLEKLGLRTIGDVLRFLPRRHIDYSKTMTIREAVGFETSGEVTVRGVVRDEAIFDGPPARYTIRLQDATGSIKVTWFNKYLAHQIRAGDEITISGKLDHGYGMPTATS...
Function: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). EC: 3.6.4.12 Catalytic Activity: ATP + ...
A0A673N5S8
MNSNDTVIRVSALVSSMCFCLVSAVELSSALPARVPPAAIPMALRVELSPSLDSTRREQQLQQELLALKHKQQLQRQILIAEFQRKHEQLSRQHEAQLQEHMKVRTVVVKHQQELLALKHQQELLEHQRKMEQHRLEQELEKQQREQKLQLLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRSLNHCISNNPRYWYGKTQHSSLDQSSPPQTSVSIYNPPAMGVYDSKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDSPISTLKKRSLDMAGDARCMFADSVCSSAPGSGPSSPNNSSHGNLCENGIS...
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Catalytic Activity: H2...
A0A0Q0RSV6
MDYDVIILGAGAGGYLAALHLAKKKKKVLIIEKEKFGGECLNYGCIPSKALIELSENIFYLKNMPGMTLDYKLNMKDWQAWKDSMIKKITGGAEGACKASGATVLYGEGKIVNKNTVNVDGKNYTADYLILDTGSVPVKIKGIDDVYYNREILAIDHIPETLVVIGGGYIGIEMGTAFRKLGSDVYIVEMKDRILPEVDEYLSRAVDKRLRDLGIKILTSSRVLGVKKNKNYTVKIENSGDIIAETVLMAVGRMPNTQGYGLENLNLEMDGRFIKTDQHKRTSVDNVYAIGDVSGMPMLAHKAFYDAYVASENILGNDTV...
Cofactor: Binds 1 FAD per subunit. EC: 1.8.1.4 Catalytic Activity: (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH Sequence Length: 428 Sequence Mass (Da): 47063
A0A1A9GJN6
MGIIGDIFGFIATPLYYAISAVLIGWHKLFTIIGLDPAGGAAWALSIIGLTVVIRALLIPLFVKQIKASRNMQLIQPRVKELQKKYGHDRERLAQETMKLYKDSGTNPFASCLPLLLQMPIFFTLFRLLDQAAKNQTAHGFLTEKLAIQFGDSKLFGHVPLAETFWNNGIWRGDGGDLGVMGVALVLVLAMTATTFFTQRQLMSKNMPADALSGPYAQQQKLLLYVLPVAFGLGGVAFPIGVLLYWTTSNLWTMGQQFYVIRNNPAPGTPAFDAKQEREKAKAAKHGVVLAVDEPTEAPVEKRPAPRQQPKKQTRQQRRQ...
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispa...
W4VPL3
MEVIKITLLPLFINLTDKEIVIIGGGKVAERRLRHLLDYKESLTIISPDVTDIMHEMIAVNKINWINTSFKSNYLAEAHLIIIATNDKKINNQIIQQAPKTAWINAAHHADRGTIHFPIILKRGRLQIAISTDGASPLLAKRIKKEIDSLLPENYESYIDFLYEARQLIKQIKLDPAEKRRLLQDIVEDPIYDKNNQQVFLNKLKNKCKR
Pathway: Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. EC: 1.3.1.76 Catalytic Activity: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin Sequence Length: 210 Sequence Mass (Da): 24227
A0A673KYF7
MAINVNLLPKECEFTVKNILVGLFCYKTQRGKFKVDSGALWNIIQYMTDRQYNPILRPHLAENPSSVSYKTEMSKRTGDRCFPNYEINNTMPDYAKLPIQMMNFVTTMHCRDYLLIIDPLDVCDAQAKKGAPTLLMAIKTQTANFENREAIRETWGNIKTLGGRQRLVRRVFLLGKSKDLHIEEKLHLESEKYGDIIQWDFVDTFFNLTLKDVLFWDWFSRRCPHARFIFKGDDDVFVRTPAVLDYLLAEETFVVGDVISNAAPIRSNGTKYYIPESFYKGLYPSYPGGGGVLYSGSLAHRLLVVSQRVHLFPIDDVYLG...
EC: 2.4.1.- Subcellular Location: Golgi apparatus membrane Sequence Length: 392 Sequence Mass (Da): 45186 Location Topology: Single-pass type II membrane protein
A0A3S3SRA2
MVEMSKDERTKAREALLSRRVEDLTVADFATVRDLVEGFGRMGGFMAPRLSEATKIMEEMRSEGCVKFLSFTGNIISTGLRGVISDLIRGGWADVIVTTCGALDHDLARSFGARYSSGEFELDDVMLNELEIHRLGNVLIPLEDYGPLIEKVMRRELPEILRGRTSISPSELASEFGRRIDDSHSFLRAAYERGVPVYVPGVIDGSFGTNLFFYAQTNKFNLDLFSDMSRILNTVFDSKKTGALIIGGGISKHHVIWWNQFKEGLDYCIYLTTAQEYDGSLSGALPKEAISWGKVKPRAKHLAVFGDVTITLPLIAGAIS...
Pathway: Protein modification; eIF5A hypusination. Function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine resi...
A0A4Y3PLP4
MRFHSKLMLIICSLLLGVIVILGITFELMLADALEKEIGRRALDTAKTVAQMEEIKQAFYTEDPAKIINPIAEKIRVSTNAAFITVGNLQGIRYSHPDPDEIGKPMVGGDNETVFEGNSIISETVGSLGPGLRGKTPIYNEAGQVIGVVSVGFLFADINETIESYRDRIVLVGIITLLLGVVCTMLLARNVKKAIFGLEPASIGRLYQENQAVLESIREGIVAVNETGAITLANQTAQRLLGQKQEKERDCLTEKQDDLVHALGLTEVIETGEAEFDREALVNEQVLIVNRVPIKDANNQITGAVASFRNRSELFEVTQE...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 528 Sequence Mass (Da): 58177 Location Topology: Multi-pass membrane protein
A0A7V9A8C4
MPIQPLPTGLPIIAPRAADSHKGTYGRALLVGGSVGMPGSISLSGQACLKGGAGLVTLAVPDAIINTVANFEPSYMTWALPTDRSGHIPLHAKSRLREKLEASSCLAVGPGLGQSQGLFHLVGHLYETFTGPMIIDADGLNLLSLRSAPLAGRAGPRVITPHLGEFRRLVGKPHLSMEDARDMASELAGRQKITVVLKGPKTLVTDGQRHWHNPTGNPGLATGGTGDVLTGLITALLAQSLDAYEAAVLAVFLHGLAADLAIETTTQAGLTATDLLSFVEAAWRDYESRRDHLST
Function: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or ...
A0A3S3SSL1
MESIKTVSKERTERLAWLSKIALTPEEVDRFTDQLNRILEFAGALDSPEVEGVEPTFHVLDLVNTFREDREEKGLEREGALATAPKVKDGFIVAPKIV
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an ...
A0A3E2TJJ4
MDLKSIYEGKKFGEILFCEPLKDYTTWGIGGPADVLVKPHNEKELQDLLIFNNENKIHTTVIGRGSNLLITDKGIRGCVLVLADNYDCISLEDTELTVLAGTKLNKAALYAIENKLTGMEEVSGIPGSVGGAVAMNAGAYNREIKDICINVKAFDLSGNEYNFTNDEMNFSYRHSKIFEQDLIVSSATFKLFYDTENKAEEKYDDYTNRRETKQPLDKKSAGSTFKRPEGSYASKLIDECGLRGYRVGDCQVSEKHCGFIINTGDATSREMLDFIEEVAGIVKEKTGFTLEREVKLIGDL
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC: 1.3.1.98 Subcellular Location: Cytoplasm Sequence Length: 300 Sequence Mass (Da): 33428
A0A4W2I5P7
MTPRARGGGRTYGAVGSTIRSAGEGKRSRPRPRAREWRGETRSLRPRPLHPTAGGDARGLLFGARRGRLESGMARSRAALLLPSLMLLLLVTPAQVSPDYQYFGQQGEGDTWEQLRLQHQEKGPMVYAICYCPLSRLEDLEALKVADSKTLSESERDRLFAKMEEDGDFVGWALDVLSPNLISTSMLGRVKYNLNALSHDTATGLVQFALDQGVNVAQVFVDTVGLPETYQERLQQRFPGIEVTVKAKADALYPVVSAASICAKVARDQAVKNWKFVEKLQDLDTDYGSGYPNDPKTKAWLRKHVDPVFGFPQFVRFSWR...
Function: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes...
A0A9E8ATU3
MRLSNLGLAFLGGTFGTAAREAVSLGLPAVSDVPWAIFTVNILGAFLLGLLLDALARSGPDEGWRRRARILVGTGFMGGFTTYSALAADTAGLLGADPGGASSPGIGLAYAVGTVLIGGLATFAGIATATTLRRGGAEVDEVADDLPIEPDAWDEDTADAGPDASADRHPGSAR
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Subcellular Location: Cell membrane Sequence Length: 174 Sequence Mass (Da): 17484 Location Topology: Multi-pass membrane protein
B0CDY1
MSVSLSRPPLWFWIGISCVWIFALAFRFWGLERFNTLVFDEVYFAKFGHNYLTQTEFFDAHPPLGKYLIALGIALKGFNTWGFRWMNALIGATIPLILSGIAYQLCKRPSYALITAVLASLDGLLLVESRYALLNVHILFFGLLAHWLVLISLNHQGMQRNGWLAAAGISFGAAIAVKWNGLGLLLGLYLLWLVAKGGQIWLGSSETPKRRLPLQKLSELSWLQMFVYLPAIALFVYGILWLPHLAQNPEFNLWQVHQEIFNYHRRVGGDEVHPYCSSWYTWPLLLKPISYFYQVTQSTLEPLPVTGPPLPQDAVKWIYS...
Pathway: Protein modification; protein glycosylation. Function: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Catalytic Activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) EC: 2.4.1.109 Subcellular Locatio...
A0A956W9C9
MTITAPKRFLESVEQSSEDRDSLVCVGLDPDLARMPDTITRGRSAGDAIFEFNKQIIESTIEFAAAYKPQLAMYMQYGPAGYEALLRTRELIPSTTPAILDCKIGDISTTMEPYARAYLDEADFDAITVNPYMGSECLQPVFDRAGKGAFLLCKTSNPGSGEIQNLTLENGQPLFVEIARKVAAWNAGSAASLGLVVGATYPAELIVVREAVPDLLILVPGIGSQAGDLAAAVDAGIDGQGRGLLINSSRSITFASAEKDFARASATAARTLRDQINAIRG
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. EC: 4.1.1.23 Catalytic Activity: H(+) + orotidine 5'-phosphate = CO2 + UMP Sequence Length: 281 Sequence Mass (Da): 29943
W4VK85
MITVIGIVMYLNNVNEMKNQTQSMSKVLSTQFSRTIDLYFEDIERLSLAIFTDSVIQDTLSNYEEDLLYNDISIRNSLYPRLFNQVYPQSDVAAVTIHTDSGTIFDYEKSGDMEVRYATEDPEWVQLLKAANKNEFLILPTSEVEQLNGQKKQVVSLIRDIYKIPQRNRIGSMKIDIDVTIFEKLLEMDNVDELEEHMRIFVMSANESVIYDHRKELIGENNVGLNLPTVTVNEPEDGTLSWQSDSYLYANDHSDFTNWNTVVLIDNEFIIYERNQILLFIAISGLVAFSVIGVISYLLSYNITKPFNGIIQKMRRVEKG...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 571 Sequence Mass (Da): 65682 Location Topology: Multi-pass membrane protein
B5Y9Z3
MRKIRLFYSFLWLVFILLSAYVFTFFPGTKTIPNKLGPFQLYAIMITMGAIFAYLAALLLGPVKGIEEELIDKFALVAIPFGLVGARLGFVLQNAEYYQNHPLEVIGITPDGFGLSGLSIHGVIVAGVLCLLLFYGWVGLRTLDLGDLGATILLIGQAFGRFGNFFNQELYGYPTSVPWKMFIDPAHRLAGYYDQAFYHPTFFYEGFLCLLGATILAYRFLHKRRFRGQIVLEYLMLYSLIRFVVEFFRIEPPSLWGLHTAQLLSLVIIVLCGIMYVLTLRFGQKLFVGEARQTP
Pathway: Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). Function: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. Catalytic Activity: 1,...
A0A5C7JZX5
MREGTGGAMHRGSTGGRRRTLTRLVTLLALVAMAAGVLLPAVGAQSPYTTLSPQSPQADDIQWLYKLVFFLALIVFIGVQIAIVYTVLRYRRRVNDERPEQLHGNKTLEVIWTIIPAIVLLAIFIPTVRTIYAHADQVEEGDFTVQVYAKQWWWEVHYADDTGEAAGVITANDIVVPQGKNVVFELYSNNVIHSFWVPQLSGKLDVMPGHENKLPIDTDNVGLYFGQCAEFCGDSHALMRFKVIVQPQETFDQWAASWKAGPSDASASFVPDGDLTKVPAAFGLCLACHQVEGTNASIAPEGLEEAPLTDTGEMGPAKYA...
Cofactor: Binds a copper A center. Function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). EC: 7.1.1.9 Catalytic Activity: 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(...
B8FLB7
MPFFSIFKREIFRKLTGKAKDRENAAFQALHQPQSWLVAGLGNPGEKYSQTRHNIGFMAADLLGEKWRLGFETHGASLFGAGLIGETPAGVIKPQSYMNLSGPPIWEIAGKFGIDRERVLVIHDDLDLPFGKIKIKKKGGHGGHKGIQSLIQSFGDGDFPRLRVGIGRPPAGQSVVDHVLGRFDAEENLVLGKVLALSGDAVETVLREGISKGMNSFNNQQITA
Function: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Catalytic Activity: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+) EC: 3.1.1.29 Subcellular Location: Cytoplasm Sequence Length: 224 Sequence Mass (Da): 24385
A0A359LYH7
MLRMSFLEHLEELRSRIIKILMGFGVAFVASLTFTAELWNAVRAPAAAALTSLGLKPDLVAIEPMEQFNIIWLKLPILTSIFLASPWILYQVWSFIAPGLYKRERRWAAPFVLCSAGLFIGGGLFAYYVAFRLGLRFLLGIGTGMGVTPMISISFYFDLFVNVILGVALVFELPVLVFFLTLLRITTPKFLLANSRYAILIIVVVAAILTPTPDIFNLTIFAAPMVVLYFGGVFASYLLVLHRENKRFPWALTLGIVLLVLLLLAAGAYIAVSKYGYTLTGSWPFLTR
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Subcellular Location: Cell membrane Sequence Length: 288 Sequence Mass (Da): 32057 Location Topology: Multi-pass membrane protein...
A0A379AIG7
MKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRIEPSLEAAFVDYGAERHGFLPLKEISREYFPSSYNAHGRPNIKDVLREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDDRTELKEALSALELPEGMGLIVRTAGVGKSAESLQWDLSFRLKHWEAIKKAAENRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSARATRGGDIEETAF...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. EC: 3.1.26.12 Catalytic Activity: Endonucleolytic cleavage of single-stra...
A0A1A9GPE0
MGVSATGKSSVARRLAELHECDFIEGDDLHPRANVAKMEAGDPLTDEDRWPWLARVAQTMREQADAGRSSVVTCSALKRAYRDRLREDVADVWFLHLHAPAAVLEDRMSRRTRHFMPVSLLASQLATLEPLAPAEHGRVVDVTPPLDDVVAAASRALAELLNESPGA
Pathway: Carbohydrate acid metabolism. EC: 2.7.1.12 Catalytic Activity: ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+) Sequence Length: 167 Sequence Mass (Da): 18314
G2KPF0
MIDLQITSENPGWNTDLPDYESVIERTVHAVFSTCPVAAEIKGSVPSIEISITLSDDESVRILNRDYRGKDKPTNILSFAMQDTEDGWEYPTPGLPCTLGDLVIARETLIREAEDEAKSFADHFTHLIVHGTLHLLGYDHIEDEDADEMEALEINILNELGIKNPYLLPGGD
Cofactor: Binds 1 zinc ion. Function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. EC: 3.1.-.- Subcellular Location: Cytoplasm Sequence Length: 172 Sequence Mass (Da): 19165
A0A1B1AIY1
MISNAITIFRTLLTIPLFALLAYGAGDFGWTPLALFLGAGLLDMVDGKVARARNETSAFGAMIDLVGDRLLTFAAVLGLIVGGDVAGVQLIAGIIIVARDLVVASLNEALPGKLGPRVGTLEKIKIAAAFAALTLLIAPSTFEQQQMAGIAALWLAAAFTVLTVAGYWMAALREFAKS
Pathway: Phospholipid metabolism. Subcellular Location: Membrane Sequence Length: 178 Sequence Mass (Da): 18518 Location Topology: Multi-pass membrane protein
W4VIG5
MPELPEVETIRQTLKQLTIGKTIQTVDIYWPKIIQEPDDYHHFIDLIKNQTIHDIRRKGGKFLLFDLNQHVLVSHLRMEGKYGGVYPQREELMAHTHVVFHFTDGTDLRYRDVRKLGTMHLQERGTELTKKPLLLVAQDPLEADFSLQTFQKKVQKSERNIKNILLDQSVIAGLGNIYVDETLFMAGIHPLTKGLSVTDEQVIQIVEASVATLKDAVKQGGTTIRSYVNSQGQIGMFQQKLNVYGQNDKACRKCEDTIMKIKVNGRGTHYCPSCQPI
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase...
A0A673MS37
MYTHYTHIQCREKVFAPFLFQILIHFMHAFLIWTFRFSLSATPGSREHDPSSQQVTKRHRKLLKTSPVRRPHTNSSHSPSSSSSSRRLSDVQESRRRIIREVCGKYRSNISRTITPHHVSRIYVEDRHKLLYCEVPKAGCSNWKRILMVLAGVANSTREINHVAVHYDNHLKRLDSFDHQGISKRLETYTKVLFIREPMERLVSAFRDKFESPNSYYHPVFGKPIISKYRVNASQTALKTGSGVTFREFIHYLLDVHRPVGMDIHWEAANQLCSPCHLHYDFIGKVETLEEDANFLLRKIGAPENLTYPSFKDGNPKAAR...
EC: 2.8.2.- Subcellular Location: Golgi apparatus membrane Sequence Length: 362 Sequence Mass (Da): 42488 Location Topology: Single-pass type II membrane protein
F0S058
MSKFCEVVNELYKIVEERKEKLPEGSYTAKLFRKGEDKILQKVGEEAVETILAFKSGDKNHTVYETADLIYHLLVALVNKGITLDEIGEELQKRMK
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) EC: 3.6.1.31 Subcellular Location: Cytoplasm Sequence Length: 96 Sequence M...
F0S3Y3
MLLSCGVDIVSIKRVEKLLERYGDRFIKKVFPEGIEYCYQKRKGELAGCIAARFALKEAIIKALSGIEKKVTLSEIVIIGGGKNLEVKLKNHKEIQLIYSISHEKDYAVAMVNVIKLK
Function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Catalytic Activity: apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] EC: 2.7.8.7 Subcellular Location: Cytoplasm Sequence Length: 118 Sequence Mass (Da): 13295
F0S460
MHSSERIGKLYIVATPIGNLEDITFRALKVLKEVDLIACEDTRRTIKLLNYYKIPVKKLVPYHEHNERKVSKKLIKELLSGKDIALVSDAGTPCISDPGYRIVSLAREKKIDVIPIPGASAVIAALSASGFPTDRFLFVGFLPKKELQLKKTIKEISKLPYTVVAYESPHRLEKTLKILKEMIPEKKIGIYREITKLNEEFLEGNPGKLLNELTLEDKLKGEFVLLFYPSKEEKENENEKSLDEILLQLKEEGNSLKTTVKEACQRTGLPKNEVYKRALELFSRD
Function: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. Catalytic Activity: cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine EC: 2.1.1.198 Subcellular Location: Cytoplasm Sequence Length: 285 Sequence Mas...
B8FEA1
MAPETWTIQKILKWTTDFFSEKQVEAPRLSAEILLSHCLDYPRIHLYTRHDQPLNPEELGRFRELVKRRAAREPVAYIVGNRDFWTLELDVNPSVLIPRPETETLVETALEVLNAAQAPMRVLDLGTGSGAIILALASEKPEHHYMAVDYSPQALETAKANAQKHNLNVDFYKGSWFEAVRCLDRFDLVVSNPPYIPSRDIPGLMPEVARYEPMSALDGGPQGMDHLALIIERAPEHLKPGGWLMLEMGFDQKELVEQVALETQAYENVRFVRDLAGHFRTAVMQRPAP
Function: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. EC: 2.1.1.297 Catalytic Activity: L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release...
A0A1F3JPG0
MRIHKAGFSVITVALLISGTLMTVLVLTKMPTWVLGGFGLIFFLLLAFIFRFFRFPNRKIEFDETMVVSPADGTIVAIEEVEENEFIKEKRIQISIFMSVWNVHINWYPVVGKILQSIHFDGKYMAAWLPKSSHENERSVVVIDTPKAGKILVKQIAGAVARRIITYAKPELECHAGDQLGFIRFGSRVDVLIPIGSEIKVQLNQKVTGGLTLLAKLPHS
PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme...
A0A7X2TSG4
MARQRLGQHFLRSQTVLERIALSVCPEPQPLVIEIGPGKGALTAHLLRRAERVIAIELDRALAVELRQKYEDEPRLTIIEGDALAADLAQWGPAVIAGNLPYYAATAIIERVLDSGAGLRWAVFLIQKEVAERMAASPGGREYGFLSVRTQLAADCAVLFRVKPAAFQPPPKVESAVVRLRPRPGVAPDPEFLAFIGHCFRQKRKMLRNNLSGLYPKDLIEAIPEGFQRAERLTLSQFAQTYRRLVAYSKETIMFTPEQAQGLAMFLAMGLEKEQQTTKKVLAAVPAESLDFKLGDKGRTAGALMAHIVSSELWFADGIE...
Function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Catalytic Activity: adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) +...
A0A1Y0I6Z8
MTDKRSLIRTFALAITCTALVALLYTSDEPELPENYKATDENEPDAFVVNGSYLEFDETGNLALQLESHQGVHFPNADQSIVGTPSVKIYQENQVPWVVNASQGQYFQEDRKLILSGDVNITRSNSNDPPLRFSTEELTLYSDTQFITTDKPVKLEDRLGTTEATGMNAWVKERRVELLSKVRGTYAQDPTHAQEPKE
Function: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Subcellular Location: Cell inner membrane Sequen...
A0A1V5L8B6
MSNSFQKNKMVCVCQVASAHGVKGEVKLFSFMEDRLNIKSYPVLFDEDGKSYEVKVTGLFKEDLLIARLNDNMDRNVAEELRGKKLYVNRDNMPDLEEEEYYHADLIGLEVVTTDGENLGIVSAIHNFGAGDILEVKKGQNSLMLPFTKKVVLKIDFDNGQMISIPLKEIFLEQENDKEGEEN
Function: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but ...
A0A4U0FGM0
MSIRLKLLFSYAAMLVVPLVLIVLTALLLVFVFRGDLQNLRSFYETQIEGIDDHDYHQLINHTIARNPALVTDPGFLTTLSDEMKTGDQFVIVLIDGNPYFVSKAIQTRTQLISRLPAFHHSGYRHEWSTKSYGNEFFSLSQYDFVPKSGQSGSLYVVTQVQPLVYFSRKYLPILLTSFLVILILTNSLLTYFMSKSIIRPLRKLHKATRKIKEGDLEFQVGVGGKDEIGQLGVAFEEMRSQLEKSIRLQLQYEENRKELVSNISHDLRTPITAIRGYVDGILDGVADSPDKIEKYVRTISAKAAEMDRLIEQLFLYSKL...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 488 Sequence Mass (Da): 55765 Location Topology: Multi-pass membrane protein
A0A4U9KTN8
MGVGAFTGAFFHVLTHAFFKALLFLGAGSVIHAMSDEQDMRSMGGLKKYLPITYATMLVGTIAIAGIPPLSGFFSKDEILAHAFVSSPVFWVLGFLGALCTAFYMFRLLYMTFFGEFRGTENQKHHLHESPVQMTIPLIVLAVLSVVGGVINLPEALHGGTWLANFLSPVFAQTNQVVEPFHLSHSTEYVLMGASALGAIIMAFIAYNKYVKKSEIPQGDGASEESGLYKLSYNKLYIDELYDTLFVRPLNSLSKFLHSVVEKAGIDGLINGIGDLFVSSGKGIRQLQSGNVGFYIFMMVIGVIAFMLYGLFTI
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+) Subcellular Location: Membrane Sequence Length: 314 Sequence Mass (Da): 34315 Location Topology: Multi-pass membrane protein
M1MY49
MKKKGKSSAGFIAIVVVILFLAFAGFKGFVVGGWQVKSFDKVITRGLDLQGGVSVLMEIQQDKVTKEELESAKQHISLRVNKLGVAETVVTTEGEKRIRVDVPGMSNSNDIVQSLSKSGNLVFKGPNGDEILTGKDVKKATAQLNQQQGGYEIGLELNDEGTKKFADATGKYIGQNIGIYLDDEQISNPRVQVQINDGKASITGKYTLEEAKSQAGLINSGALPLPVKAVTVSNVGAELGATAFPNSIKAGVIGVGLVFLFMLINYRRQGLMADIALTLYIVLTLLVFVEVGVTLTLPGIAAFLLTIGVAVDANILTFER...
Function: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. Subcellular Location: Cell membrane Sequence Length: 421 Sequence Mass (Da): 44860 Location...
A0A5B8UTR0
MEKFIKKFSQTGINDIAEVGGKNASLGEMFSHLTARGLLIPNGFAVTASAYRYFITCNDLEDKLGELMKGLNRKDFSNLSETGARARKLIMDGHIPSDLGFAITDAYDYLFDNDDQPVAVRSSATAEDLPDASFAGQHESYLNVQGHTHLLYSVKRCYASLYTDRAIKYREDKGFEHSKVFLSVGVQQMVRADIGCSGVGFTLEPESGFRDVVHLAGVWGLGENIVQGTVTPDEFLVFKPALKNKKRAILQKNLGSKSKMMIYADESDEANSTINKDTPRDMQEKFVLNDREVEKLANWALIIEEHYQKPMDFEWAKDGC...
Pathway: Carbohydrate biosynthesis; gluconeogenesis. Function: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. EC: 2.7.9.2 Catalytic Activity: ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate Sequence Length: 809 Sequence Mass (Da): 89492
A0A2S0R4Z8
PRMNNMSFWLLPPSLFLLIMSMIIGSGSGTGWTVYPPLSNNMFHSNMSVDITIFSLHIAGISSIMGAINMISSIMNIRSMMMNMNKISLFSWSILLTSILLLLSLPVLAGAITMLLFDRNINTSFFDPSGGGDPILYQHLF
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A455XGQ9
MGKTAKSLVHLSAQQEGDHIIIRITDDGKGMRPEVIRNKAIEKGLINAESVSSLDDEQSLGLILLPGFSTKDEISSVSGRGVGMDVVKTNIEKLSGKISITSVPGKGSEFTISLPLTLAILPVLLLRLCNQSFAVPLSLVREILSVPPSDLQQIAGKATMVVRGEVLPVLSLASLIGWEQTDKPEVGVLMQIEKNSFILSADGFAGHDDVVIKSLDTFRPKGVAGVTMSSEGEIILILDIKELLGELCR
Function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. EC: 2.7.13.3 Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Length: 249 Sequen...
A0A444L6F3
MEGDLWFALLQIFKMGGHTRQILLGTSDFGRMIGVSQQTASRRLLELVESGLITRELTPDGQLVMITEKGMDAIREVYNALKMGLEGIDNVKFLNGYVFSGFGEGAYYVTKSGYREQFSEKLGFAPFPGTLNLKLRSSADIRARNELEALPGIIIKGFTNSERTYGDVKCFLAKVNDTADGAILMIHRTHYGKEVLEIIAPENLRKKFGLRDGDMVQLKVFLNRDHAAQSHLG
Cofactor: Binds 1 Mg(2+) ion per subunit. Pathway: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1. Function: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). EC: 2.7.1.161 Catalytic Activity: CTP + riboflavin = CDP + FMN + H(...
A0A3D8HWY7
MKKIVLICAYICEILIANSLRQELNYLQYNDIAYIRAHLDQYKSQCENGNGNSCQIIGSYYKRIYQISGYKDAEIEKASLMWFIKGCNLKSGSSCYLASLGYGNISKLPTHLPKDEKKAFELHKKGCDYGHSVSCNYVGYYYEELSNKESDENIKNEYQIKAKLFHQKASELKKTAK
Function: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid EC: 3.5.2.6 Subcellular Location: Secreted Sequence Length: 177 Sequence Mass (Da): 20362
A0A7C3C800
MTVRFYKAHGAGNDFLITWAEDVPSGDRADLARAICARHTGVGADGWYVVERPGDGVDARVHLYNSDGSEAELSGNGTRCVAAVLCRLGLAGEELRIETGAGLRTLRLLGRSGETFRFEMAMGEPVIRDEDVDVELALSRGLCRATILDVGNPQCAVFVDRFPDDWREIGAEIERHPRFPNRTNVSFVRVIGRHAVDARFFERGAGETLSSGTGAVGAAVAAIVRGEAESPVTVRTPAGELDVRWDGEVRLTGPATVVASGEFFYSQGGG
Pathway: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. Function: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacte...
A0A8J6HH62
MPPLSILNKPGKLSIPVDSGLSSIILNYRLKGFLSLDVDVSHLEVNQCEPAAPAANEISIFHGTHKCHNTTSQCLYRAQATSSNWSRGKYQCLCRPGFYSPHYDGVFNGTLVEVSWQDQEENNTDTWRTVFQCKQCAPGCHFCTDPSPCLATYHWPFRITLLVFSISCALCTMIINAYMFKHRKLKVFKVASPIFLSITLFGCATMYLEMAAIFPVLDRYSCIATKWSRHLGFCVTYTALLMKTWRVSLTYRVKSAHKVKLTDKQLLQWMVPILLVMLIYLGTWTLSDTPTAEEIVDNEDLRFKQCVYNWWDHSLAIGEV...
Function: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excita...
F0S3U8
MRVVEGKLKAEGIKFAIAVSRFNSFITERLLEGAIDCIVRHGGKEEDITVIKVPGAFELPLVAKKLAKMDFDAVIALGAVIRGETPHFDYVAAEVSKGIANVSLEAEKPIAFGVLTTDTVEQAIDRAGTKAGNKGWEAALSAIEMVNVLRELK
Pathway: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2. Function: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This ...
A0A2T6D4K0
MGGPESPGSWQAPGHKYLCGSLLEGCDFMGDSARLVLVLREALEKGSLPVSAMVGVSGGIDSCTLVHALVAAGSRPVVTHYDHGWGPAAAEDPAFVGELAARLGLQFRSGAAHPAPARQREDEARRQRYAFFAQQAVELGCEDLVLAHHADDQVETLLLQMLRGGGSGAVGMRETSTMRVTTDGREVVLRVHRPWLGVWRREIEAYAQLQRIDWKEDATNLDGAHLRNRLRHDLVPLLEAIGGPHVRGKLLDFAATRRDEQEWLDAICKPWAMCEKLSVKDLRAQPEFALRRIIWAWLLARGVAGLRRRHVEEVAAMVAV...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
E7H310
MEQFNLPVSMLRQHCFCPRIPFFQLMRGIQPVGPMWLQQGLNHHVREEMLAKRRKLSRFGISPQSFRFLEDIKLYNDSLGLHGICDGAIFTAKEVIPLEFKLSEVSPPMGARLQLAAYAMLLEYQEKRKISRRFVLYGQKGHTLEVIVDIKLRAEVHTVANLIREACKKAIVPHTAATESQCAQCEYQNFCADRF
Cofactor: Mg(2+) or Mn(2+) required for ssDNA cleavage activity. Function: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences ...
A0A916QS45
MNNTKEKFVVTAAQMRQIEERIFVAGMPVAALMEKVAGLVTRKIVKLLNPNISKIGILVGPGHNGGDALVIARELHFQGYEIIVYCPMQKLKELTNAHSKYLQSLGVNFVDNISPVKNCDLLIDGLFGFGLEREITGYLAKAINEINSWKKHIFSIDLPSGIHTDTGAILGTAISANHTFCLGLWKQAFLQDQALEYIGTSELIDFDIPLADITAILGEFPTIERITKTSATANFPLPLSPITYKYKNGNLLLIVGSHRYSGAAILTGLGARATGVGMLSIAVPKSIKPILNNHLPEALIIGCPETETGTIKQLPEDIDL...
Cofactor: Binds 1 potassium ion per subunit. Function: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that...
A0A7X2TTR7
MGSALMEGWARSGIKGIVSTRSTGGNREAAAAADIVIVAVKPHVVQVVLEEIRDVLREGQILVSAAAAIPLAAIEKIVRVPAFRVLSNLPAAIGKGATAIATHAADRTRVVSLFARIGSVELVDEAVLHAVTALSGSGPAYAYLVIEALASGGVKQGLKWDVALRLTAQTVLGAAAMVIETGVHPAELRDRVVTPGGTTIAGLHELEKSGVRGALMAAVEAGAKRSEARAQELS
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Catalytic Activity: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH EC: 1.5.1.2 Subcellular Location: Cytoplasm...
A0A318N079
MTKTGLILAIDTKDYDLAEQWAQIADLTGQMIKIGMEFTYACGFDAVRKLARGRQVFLDLKLHDIPNTVASAIASLVSVKPAMLTIHTLGGKDMIKAARKAIDVNFPENQKPLLLGVTVLTSMDQENLNSVNLHTTPLEQVMKLAGMALDAGVDGLVCSPEEVATLRKFYEDKVVLVVPGIRLENAKTDDQKRIMTPALAHKAGANWIVVGRPITQSANPQQVAEEIICQLQD
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. Function: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). EC: 4.1.1.23 Catalytic Activity: H(+) + orotidine 5'-phosphate = CO2 + UMP Sequence Length: 233 Sequence Mass (...