| <table border="1"> |
| <tr><td>Year</td><td>Title</td><td>Role</td><td>Notes</td></tr> |
| <tr><td>1993</td><td>Class of '61</td><td>Lily Magraw</td><td>TV movie</td></tr> |
| <tr><td>1993</td><td>Blind Spot</td><td>Phoebe</td><td>TV movie</td></tr> |
| <tr><td>1993</td><td>Tales of the City</td><td>Mary Ann Singleton</td><td>Miniseries; 7 episodes</td></tr> |
| <tr><td>1994</td><td>Law & Order</td><td>Martha Bowen</td><td>Episode: "Blue Bamboo"</td></tr> |
| <tr><td>1998</td><td>More Tales of the City</td><td>Mary Ann Singleton</td><td>Miniseries; 6 episodes</td></tr> |
| <tr><td>1999</td><td>Love Letters</td><td>Melisa Gardner Cobb</td><td>TV movie</td></tr> |
| <tr><td>2000</td><td>Running Mates</td><td>Lauren Hartman</td><td>TV movie</td></tr> |
| <tr><td>2001</td><td>Further Tales of the City</td><td>Mary Ann Singleton</td><td>Miniseries; 3 episodes</td></tr> |
| <tr><td>2001</td><td>Wild Iris</td><td>Iris Bravard</td><td>TV movie</td></tr> |
| <tr><td>2002</td><td>King of the Hill</td><td>Marlene</td><td>Voice; Episode: "Dang Ol' Love"</td></tr> |
| <tr><td>2003–2004</td><td>Frasier</td><td>Mindy / Charlotte</td><td>6 episodes</td></tr> |
| <tr><td>2006</td><td>American Dad!</td><td>Doctor Gupta</td><td>Voice; Episode: "Roger 'n' Me"</td></tr> |
| <tr><td>2008</td><td>John Adams</td><td>Abigail Adams</td><td>Miniseries; 7 episodes</td></tr> |
| <tr><td>2010–2013</td><td>The Big C</td><td>Cathy Jamison</td><td>40 episodes, also executive producer</td></tr> |
| <tr><td>2016</td><td>Inside Amy Schumer</td><td>Herself</td><td>Episode: "Brave"</td></tr> |
| <tr><td>2017</td><td>Red Nose Day Actually</td><td>Sarah</td><td>Television short film</td></tr> |
| <tr><td>2017</td><td>Last Week Tonight with John Oliver</td><td>Florence Harding</td><td>Segment: "Harding"</td></tr> |
| <tr><td>2017–present</td><td>Ozark</td><td>Wendy Byrde</td><td>20 episodes</td></tr> |
| <tr><td>2017</td><td>Sink Sank Sunk</td><td>Mitzi Mills</td><td>TV movie</td></tr> |
| <tr><td>2018</td><td>BoJack Horseman</td><td>Herself</td><td>Voice; Episode: "The Dog Days Are Over"</td></tr> |
| <tr><td>2019</td><td>Tales of the City</td><td>Mary Ann Singleton</td><td>Main cast</td></tr> |
| <tr><td>2019</td><td>Portrait Artist of the Year</td><td>Herself</td><td>Sitter for the finale</td></tr> |
| </table> |
|
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