| Year Title Role Notes | |
| 1993 Class of '61 Lily Magraw TV movie | |
| 1993 Blind Spot Phoebe TV movie | |
| 1993 Tales of the City Mary Ann Singleton Miniseries; 7 episodes | |
| 1994 Law & Order Martha Bowen "Episode: ""Blue Bamboo""" | |
| 1998 More Tales of the City Mary Ann Singleton Miniseries; 6 episodes | |
| 1999 Love Letters Melisa Gardner Cobb TV movie | |
| 2000 Running Mates Lauren Hartman TV movie | |
| 2001 Further Tales of the City Mary Ann Singleton Miniseries; 3 episodes | |
| 2001 Wild Iris Iris Bravard TV movie | |
| 2002 King of the Hill Marlene "Voice; Episode: ""Dang Ol' Love""" | |
| 2003–2004 Frasier Mindy / Charlotte 6 episodes | |
| 2006 American Dad! Doctor Gupta "Voice; Episode: ""Roger 'n' Me""" | |
| 2008 John Adams Abigail Adams Miniseries; 7 episodes | |
| 2010–2013 The Big C Cathy Jamison 40 episodes, also executive producer | |
| 2016 Inside Amy Schumer Herself "Episode: ""Brave""" | |
| 2017 Red Nose Day Actually Sarah Television short film | |
| 2017 Last Week Tonight with John Oliver Florence Harding "Segment: ""Harding""" | |
| 2017–present Ozark Wendy Byrde 20 episodes | |
| 2017 Sink Sank Sunk Mitzi Mills TV movie | |
| 2018 BoJack Horseman Herself "Voice; Episode: ""The Dog Days Are Over""" | |
| 2019 Tales of the City Mary Ann Singleton Main cast | |
| 2019 Portrait Artist of the Year Herself Sitter for the finale | |