| County,Location,mi,km,Exit,Destinations,Notes | |
| Polk,West Des Moines,0.000,0.000,—,"I-35 – Minneapolis, Kansas City",Western end of Iowa 5 overlap | |
| Polk,West Des Moines,1.279,2.058,102,S. 35th Street,- | |
| Polk,West Des Moines,2.731,4.395,101,Veterans Parkway,- | |
| Polk,Des Moines,4.958,7.979,99,"Iowa 28 – Norwalk, Martensdale",- | |
| Warren,Des Moines,6.985,11.241,97,CR R57 (Fleur Drive) – Des Moines Int'l Airport,- | |
| Warren,Des Moines,8.153,13.121,96,CR R63 (SW 9th Street),Last exit to be numbered according to Iowa 5's mileage. | |
| Warren,Des Moines,11.093,17.852,70,"US 65 south / US 69 – Des Moines, Indianola","Western end of US-65 overlap. From this point, exit numbers follow the mileage of US-65." | |
| Polk,Allen Township,13.567,21.834,72,Iowa 5 south – Carlisle,Eastern end of Iowa 5 overlap | |
| Polk,Allen Township,14.558,23.429,73,SE 64th Avenue,To Army Post Road | |
| Polk,Pleasant Hill,17.905,28.815,77,"SE Vandalia Road, Pleasant Hill Boulevard",- | |
| Polk,Pleasant Hill,20.016,32.213,79,Iowa 163 (E University Avenue) – Pleasant Hill,- | |
| Polk,Altoona,23.666,38.087,83,US 6 (Hubbell Avenue) / 8th Street – Altoona,- | |
| Polk,Altoona,24.649,39.669,84,"I-80 / US 65 north – Council Bluffs, Davenport",Eastern end of US 65 overlap | |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus | |