| County,Location,mi,km,Destinations,Notes | |
| Blount,Chilhowee,0.0,0.0,"US 129 (SR 115 / Calderwood Highway) – Fontana Dam, Maryville",Western segment southern terminus | |
| Blount,Walland,16.9,27.2,"US 321 (SR 73 / East Lamar Alexander Parkway) – Townsend, Maryville",Interchange | |
| Sevier,Wears Valley,33.0,53.1,"US 321 (SR 73 / Wears Valley Road) – Townsend, Pigeon Forge",Western segment northern terminus | |
| Sevier,Pigeon Forge,-,-,"US 321 (SR 73) / US 441 (SR 71) – Pigeon Forge, Gatlinburg, Great Smoky Mountains National Park",Future interchange (unfunded) | |
| Sevier,Pittman Center,-,-,SR 416 (Pittman Center Road),Future interchange (unfunded) | |
| Cocke,Cosby,0.0,0.0,"US 321 / SR 32 (Cosby Highway) – Gatlinburg, Newport",Eastern segment southern terminus | |
| Cocke,,5.6,9.0,"I-40 – Knoxville, Asheville","Eastern segment northern terminus; I-40, exit 443" | |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Unopened,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Unopened,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Unopened,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Unopened,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Unopened,1.000 mi = 1.609 km; 1.000 km = 0.621 mi Unopened | |